Molecular Signatures Differentiate Immune States in Type 1 Diabetes Families

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Page 1 of 65 Diabetes

Molecular signatures differentiate immune states in Type 1 diabetes families

YiGuang Chen1, Susanne M. Cabrera1, Shuang Jia1, Mary L. Kaldunski1, Joanna Kramer1,

Sami Cheong2, Rhonda Geoffrey1, Mark F. Roethle1, Jeffrey E. Woodliff3,

Carla J. Greenbaum4, Xujing Wang5, and Martin J. Hessner1

1The Max McGee National Research Center for Juvenile Diabetes, Children's Research Institute of Children's Hospital of Wisconsin, and Department of Pediatrics at the Medical College of Wisconsin Milwaukee, WI 53226, USA.

2The Department of Mathematical Sciences, University of WisconsinMilwaukee, Milwaukee, WI 53211, USA.

3Flow Cytometry & Cell Separation Facility, Bindley Bioscience Center, Purdue University, West Lafayette, IN 47907, USA.

4Diabetes Research Program, Benaroya Research Institute, Seattle, WA, 98101, USA.

5Systems Biology Center, the National Heart, Lung, and Blood Institute, the National Institutes of Health, Bethesda, MD 20824, USA.

Corresponding author: Martin J. Hessner, Ph.D., The Department of Pediatrics, The Medical College of Wisconsin, Milwaukee, WI 53226, USA Tel: 01114149554496; Fax: 01114149556663; Email: [email protected].

Running title: Innate Inflammation in T1D Families

Word count: 3999 Number of Tables: 1 Number of Figures: 7

For Peer Review Only Diabetes Publish Ahead of Print, published online April 23, 2014 Diabetes Page 2 of 65

ABSTRACT

Mechanisms associated with Type 1 diabetes (T1D) development remain incompletely defined.

Employing a sensitive arraybased bioassay where patient plasma is used to induce transcriptional

responses in healthy leukocytes, we previously reported diseasespecific, partially IL1 dependent,

signatures associated with pre and recent onset (RO) T1D relative to unrelated healthy controls (uHC).

To better understand inherited susceptibility in T1D families, we conducted crosssectional and

longitudinal analyses of healthy autoantibodynegative (AA) high HLA risk siblings (HRS, DR3

and/or DR4) and AA low HLA risk siblings (LRS, nonDR3/nonDR4). Signatures, scored with a

novel ontologybased algorithm, and confirmatory studies differentiated the RO T1D, uHC, HRS, and

LRS plasma milieus. Relative to uHC, T1D family members exhibited an elevated inflammatory state,

consistent with innate receptor ligation that was independent of HLA, AA, or disease status and

included elevated plasma IL1α, IL12p40, CCL2, CCL3, and CCL4 levels. Longitudinally,

signatures of T1D progressors exhibited increasing inflammatory bias. Conversely HRS possessing

decreasing AA titers revealed emergence of an IL10/TGFβ mediated regulatory state that paralleled

temporal increases in peripheral activated CD4+/CD45RA/FoxP3high regulatory Tcell frequencies. In

AA HRS, the familial innate inflammatory state was also temporally supplanted by immunoregulatory processes, suggesting a mechanism underlying the decline in T1D susceptibility with age.

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Type 1 diabetes (T1D) arises through autoimmunity towards the insulin producing pancreatic βcells.

It is a complex disease, developing through the interaction of an incompletely defined combination of

genetic susceptibilities (1) and environmental factors (2, 3). Inherited risk for T1D is largely

conveyed by the human leukocyte antigen (HLA) locus (4); however changing environmental

stressors that potentiate βcell autoimmunity (viruses, diet and/or altered gut microbiome) may account

for the increasing incidence observed in most developed countries (57). Supporting this possibility is

the decreased proportion of “highrisk” HLA genotypes among present new onset T1D patients (8).

T1D pathogenesis involves innate immune activity (911) coupled with failures in central and

peripheral tolerance mechanisms that enable expansion of diseasemediating autoreactive T

lymphocytes. Other immune cell types are involved, including Blymphocytes, as evidenced by the

development of autoantibodies (AAs) towards islet antigens that precede onset in ~95% of patients (12

14). Chemokines and cytokines are also involved in T1D pathogenesis by influencing immunocyte

activity, impairing βcell function and inducing βcell death (15).

T1D possesses a clinically silent preonset period that likely lasts years in many patients (16). This

time of progressive βcell loss represents a window for interventions aimed at preserving islet function

and delaying and/or preventing T1D. Detection of multiple AA specificities is presently the best

predictive biomarker (17, 18), though it is thought that AA do not directly mediate T1D development

(1921). Altered cytokine milieus represent a potential biomarker for T1D; however they are generally

dilute and difficult to directly measure in the periphery. Furthermore, measurement of a single or few

cytokines may be uninformative as combinatorial effects are likely important.

Measures are needed that can detect alterations in the immune state associated with T1D progression

or nonprogression. Towards this goal, we have utilized a sensitive and comprehensive genomics

based assay whereby serum or plasma borne mediators are used to drive transcription in a well

controlled “reporter” peripheral blood mononuclear cell (PBMC) population (10, 2225). Plasma of

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recently diagnosed (recent onset; RO) T1D patients, when cultured with unrelated healthy PBMC,

induces a diseasespecific signature compared to plasma of unrelated healthy controls (uHC). This

signature includes upregulation of IL1 cytokine family members, chemokines, immune receptors and

signaling molecules, as well as downregulation of genes involved with immuneregulatory processes,

suggesting that RO T1D plasma possesses higher levels of proinflammatory mediators and lower levels

of antiinflammatory factors. Importantly, this signature has been detected years prior to T1D onset, before the appearance of AAs (10, 24).

By using crosssectional and longitudinal studies of progressors and nonprogressors to T1D, a novel

quantitative signature scoring algorithm and targeted followup studies, we herein report the presence of

an innate inflammatory state in T1D families that is independent of AA status, HLA haplotypes, or T1D progression. Importantly, among healthy siblings of probands possessing high risk HLA haplotypes, we

have identified agedependent, regulatory processes that parallel temporal increases in peripheral

activated regulatory T (Treg) cell frequencies. This observation offers mechanistic insight to the age

dependent decline in T1D susceptibility.

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RESEARCH DESIGN AND METHODS

Study Subjects

Subjects were recruited through Children’s Hospital of Wisconsin (CHW) and diagnosis of T1D was

defined per World Health Organization criteria (26). All RO T1D subjects (n=47) were positive for >1

AA. To avoid inducing transcription due to factors related to hyperglycemia, samples were collected 2–

7 months after diagnosis from subjects with histories of good glycemic control. Control subjects, free of

known infection at sample collection, belonged to three groups: AA siblings of probands possessing

either highrisk HLA genotypes (DR3 and/or DR4, termed high risk siblings, HRS, n=30) or lower risk

HLA genotypes (non DR3/DR4, termed low risk siblings, LRS, n=42), and uHC (n=44) possessing no

family history of T1D. Details of the studied subjects are provided in Online Supplemental Table 1.

The study was approved by the Institutional Review Board of CHW (IRB 0115) and written informed

consent was obtained from subjects or their parents/legal guardians.

Peripheral blood was drawn into acid citrate dextrose solution A or K+EDTA anticoagulant. Ficoll

Histopaque (Sigma Aldrich, St. Louis, MO) density gradient centrifugation was used to separate blood

components immediately postdraw and plasma was stored at 80°C until use. Measurements of AAs

targeting glutamic acid decarboxylase (GAD), insulinoma antigen 2 (IA2), insulin (INS) and zinc

transporter 8 (ZnT8) were conducted as described (27). Subjects were genotyped for HLA-DQB1 and

haplotypes were inferred using Caucasian haplotype frequencies as described (24, 28).

Plasma Induced Signature Analysis

Transcription induced in cryopreserved PBMCs (UPN727, Cellular Technology Ltd., Shaker Heights,

OH) after coculture with 40% subject plasma in RPMI 1640 medium was measured using the

Affymetrix GeneChip Human Genome U133 plus 2.0 array (Affymetrix, Santa Clara, CA) as

previously described (24). The statistical significance of differentially induced transcription was

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assessed though ANalysis of VAriation (ANOVA) and false discovery rates (FDR) using Partek

Genomics Suite 6.5 (Partek, Saint Louis, MO). Datasets were analyzed by the Database for Annotation,

Visualization, and Integrated Discovery (DAVID) (29) and Ingenuity Pathway Analysis (IPA) package

(Ingenuity Systems, Redwood City, CA). Hierarchical clustering was conducted with Genesis (30).

Data files are available through the NCBI Gene Expression Omnibus (31) (accession number

GSE52724).

25-plex ELISA

Plasma cytokine levels were assayed with the BeadLyte cytokine assay kit (Millipore, Billerica, MA)

and a BioPlex Luminex 100 XYP instrument. Concentrations were calculated with the BioPlex

Manager 4.1 software; a fiveparameter curvefitting algorithm was applied for standard curve

calculations.

Flow cytometry studies

PBMCs were stained with the fixable Live/Dead Violet dye (Life Technologies, Grand Island, NY) for

30 minutes on ice, followed by surface staining for antiCD4 (clone RPAT4), antiCD25 (clone M

A251), antiCD45RO (clone UCHL1), antiCD45RA (clone HI100), and antiCD127 (clone HIR7R

M21) (BD Bioscience, San Jose, CA), on ice for 30 minutes, followed by intracellular staining with anti

FOXP3 (clone PCH101) (eBioscience, San Diego, CA). Each analysis included fluorescence minus one

(FMO) controls to ensure correct gating. Stained cells were analyzed on a LSR II flow cytometer (BD

Bioscience).

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RESULTS

Cross-sectional plasma-induced signatures of healthy siblings of T1D patients

Siblings of probands have ~6% probability of developing T1D, and most of those that progress to

disease possess a DR3 and/or DR4 HLA haplotype (1, 32). To better understand the inherited

susceptibility present in T1D families, we examined plasma induced signatures of RO T1D patients,

uHC, and healthy AA siblings of probands possessing or lacking DR3 and/or DR4 alleles (abbreviated

HRS and LRS, respectively).

The comparison of transcripts induced by plasma of RO T1D patients to those induced by each of the

healthy cohorts, identified three distinct signatures where the number of regulated probe sets was

inversely related to the genetic risk possessed by the cohort (Figure 1A). Hierarchical clustering of the

1,383 probe set union encompassed by these three comparisons found the RO T1D and HRS groups

most similar. Unexpectedly, these exhibited intermediate relatedness to the LRS and uHC cohorts

which were most distinct from one another (Figure 1B). A union of 2,422 regulated probe sets was

identified among all 6 possible pairwise comparisons (Online Supplemental Table 2). The additional

probe sets captured by this larger analysis did not alter the hierarchical clustering of the cohorts (Figure

1C) confirming that the LRS cohort was indeed most distinct from that of the uHC cohort.

To focus the ontological studies on transcripts most distinctive of each group, we filtered the 2,422

probe set union, retaining for each cohort transcripts exhibiting the highest and lowest induced

expression relative to each of the three other groups (Figures 1D and 1E). These cohortassociated

probe sets were then independently subjected to pathway analysis.

Consistent with a family history lacking autoimmunity, ontological analysis of the uHCassociated

data set revealed the lowest induction of genes associated with immune activation (Figure 2, additional

annotations are shown in Figure 3). These included IL1 family members (IL1A, IL1B, IL1R1),

cytokines (CXCL1, CXCL2, CXCL3, CCL4), immune receptors (CD93, FCER1G), and transcripts

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related to inflammatory mediator synthesis (PTGS2, PTGES). uHC plasma induced higher expression

of genes implicated in regulating immune responses through protein phosphatase activity (PTPN4, SSH2,

PPP3CA, PPP3CB) and protein ubiquitination (SMURF1, SMURF2, ITCH, UBR2).

Unexpectedly, transcripts upregulated by LRS plasma were consistent with an inflammatory response, cytokine activity and exposure to bacterial antigens (Figure 2). Many proinflammatory annotations that exhibited the lowest induction by uHC plasma were most highly induced by LRS plasma. These included chemokines (CCL2, CCL3, CCL4), pattern recognition receptors (CD14, TLR2), as well as immune receptors, growth factors, signaling molecules and transcription factors involved in promoting immune responses (FCAR, PLAUR, TREM1, NLRP3). Transcription downregulated by LRS plasma relative to the other cohorts was related to TGFβ signaling (TGFBR2, SMAD9, SMAD5, SKI, SKIL), transcriptional regulation/repression (NRIP1, NCOA3, TBL1XR1, SUZ12) and regulation of immune activation (PTPRC).

Among the three T1D family cohorts, hierarchical clustering found the RO T1D intermediate to the

LRS and HRS. While RO T1D plasma induced transcription consistent with innate immune activation, it was to a lesser degree than that of LRS plasma (Figure 2). Previously (24), we identified a 762 probe set signature when comparing transcription induced by RO T1D and uHC plasma. Given its intermediate positioning in this analysis, only 128 probe sets were exclusively associated with the RO

T1D cohort after filtering for the ontological studies. RO T1D plasma induced increased expression related to regulation of apoptosis (PTEN, TCF7L2); regulation of protein kinase activity (IRAK3,

SPRY2); transcriptional regulation (BACH1, ZNF643, ZNF709); and adhesion and inflammation (NRP2,

CD109, ANTXR2). RO T1D plasma induced underexpression of transcripts related to regulation of immune responses through ubiquitin mediated proteolysis (CBLB, PIAS1, SIAH1, RNF125); transcriptional regulators (KLF12, SLC11A1, ZNF224) and ATPdependent helicase activity (DDX52,

XRCC6, HELB).

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Subjects within the HRS group have the greatest probability of T1D progression among the three

healthy cohorts, yet LRS plasma induced more robust transcription related to innate inflammation.

Notably, ontological analysis of probe sets uniquely upregulated by HRS plasma identified activities

related to regulation of T cell/immune cell activation (IL2RA, ARHGDIB), transcriptional regulation

(UBTF, EIF2C1, TXNIP, ANP32A) transcriptional repression (ZEB1, NCOA2, BCL11B), and cell

growth/survival (CD37, TRAF4, CFL1, IFI16) many of which are involved in the attenuation of immune

responses (Figure 2). HRS plasma downregulated transcripts associated with cell adhesion and

migration (ADAM9, GREM1, ITGA2, NRP1), positive regulation of cell proliferation (EREG, ADM,

TNS3) and signal transduction (MTSS1, MITF, NPFF).

The crosssectional profiling suggest that an inflammatory state exists in T1D families. This is

supported by the distinct underinduction of inflammatory transcripts by uHC relative to LRS, RO T1D

and HRS plasma. Unexpectedly, LRS plasma induced the most robust induction of proinflammatory

transcripts, consistent with the inheritance of risk not related to the HLA. The data also suggest that in

HRS, where inheritance of highrisk HLA haplotypes increases the likelihood of adaptive autoimmune

responses, the underlying inflammatory state is actively attenuated.

Mediators underlying cohort signatures

Upstream regulator analysis was performed on the crosssectional data sets (Table 1). The IL1

pathway was activated when analyzing probe sets of the RO T1D:uHC and LRS:uHC comparisons (Z

scores >2.8), and inhibited when analyzing probe sets of the HRS:LRS comparison (Z score <2.7).

Analysis of the uHCassociated probe sets also detected inhibition of the IL1 pathway (Z score <2.4),

suggesting that IL1 contributes to the inflammatory bias observed in T1D families relative to uHC. The

partial IL1 dependence of the RO T1D:uHC signature was confirmed by introducing IL1 receptor

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antagonist (IL1RN) to cocultures (Figure 3A) which modulated IL1 dependent components of the RO

T1D:uHC signature by directionally altering expression of 583/762 probe sets (76.5%, X2 p<10E6).

Consistent with the failure of LRS plasma to induce genes related to immunoregulatory processes,

upstream regulator analysis identified IL10 and TGFβ as potential mediators, showing the most

significance when analyzing the LRS:uHC comparison (p=1.8E22 and 5.7E17, respectively). Among

the T1D family cohorts, IL10 and TGFβ were most significantly identified as potential regulators

when analyzing the HRS:LRS comparison (p=4.0E5 and 3.6E9, respectively), consistent with the

induction of immunoregulatory genes by HRS plasma. The dependence of the HRS signature on IL10

and TGFβ was confirmed by introducing αIL10R and αTGFβR antibodies to cocultures (Figure 3B)

which directionally altered expression of 549/612 genes (89.7%, X2 p<10E6) of the HRS:LRS signature.

Plasma cytokine levels of the four cohorts were investigated (Figure 4). Significantly higher levels of

IL12p40, IL1a, CCL2, CCL3, and CCL4 were detected in RO T1D compared to uHC plasma. These

cytokines were also significantly elevated in the LRS and/or HRS cohorts relative to uHC, further

indicating the presence of an inflammatory state in T1D families that is independent of AA, HLA status, and disease progression. Unlike the signature studies, direct cytokine measurements did not differentiate the T1D family cohorts.

Longitudinal analyses of progressors and non-progressors

Plasma induced signatures were used to longitudinally study 5 T1D progressors. As we have previously observed (10, 24, 25), crescendos in induced proinflammatory transcription with coincident reductions in induced regulatory transcription were associated with T1D progression (Figure 5). This pattern was evident in the DR3/DR4negative “Progressor A” at 5.3 years and the DR3/DR4positive

“Progressor D” at 4.1 years prior to T1D onset, which was prior to the emergence of AAs in these two subjects. This pattern was observed in all 5 T1D progressors examined (Online Supplemental Figure 1).

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Plasma induced signatures were used to longitudinally study 27 nonprogressors (9 AA+ HRS, 12 AA

HRS and 6 AA LRS; all shown in Online Supplemental Figure 1). In AA+ HRS, greater inflammatory

bias was evident immediately prior to, or associated with, increases in the number of AA specificities

detected. The opposite was also observed, with greater regulatory bias being associated with decreases

in the number of detected AA specificities (Figure 5, subjects AA+ HRS C and AA+ HRS E). As a

group, the AA HRS exhibited reduced temporal induction of inflammatory components and increased

temporal induction of regulatory components of the 1,374 crosssectional data set. This overall pattern

was less evident among AA LRS (Figure 5, subjects AA HRS I and AA HRS K).

Overall, these analyses support that plasma induced signatures captured temporal alterations in

immunological balance within T1D family members. The data also indicate that a single transcript may

not be informative, but combinations of transcripts may comprehensively capture the nature of the

immune state.

Ontology-based quantitative scoring of plasma-induced signatures

As defined by the ontological analyses and illustrated in Figure 5, the regulated probe sets identified in

the crosssectional studies can be broadly considered as “inflammatory” or “regulatory”. Therefore,

signatures were quantitatively scored with a composite inflammatory index (I.I.com) (formulas provided

Supplemental Data 1) determined by calculating an average ratio between the mean log intensity of the

inflammatory genes vs the mean log intensity of the regulatory genes of the four crosssectional data

subsets.

The mean I.I.com of RO T1D patients was significantly higher than that of LRS, HRS and uHC, and

with the exception of the HRS:uHC comparison, it was significantly different between comparison of

any of the cohorts (Figure 6A). All 5 longitudinally monitored T1D progressors possessed regressions

of I.I.com versus time that exhibited positive slopes (Figure 6B). The I.I.com for all HRS AA+ non

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progressors that persistently possessed titers for >1 AA specificity also exhibited positive slopes (Figure

6C, subjects A, B, and C), whereas most AA+ HRS subjects possessing transient or decreasing titers

exhibited temporally decreasing I.I.com (Figure 6C, subjects E, G, I, and J). Notably, AA+ HRS subjects

F and H exhibited positive slopes, indicative of increasing inflammatory bias despite decreases in AA

titers. The I.I.com plots of most longitudinally monitored AA HRS subjects (10/12, 83%) exhibited

negative slopes indicative of decreasing inflammatory bias over time; this pattern was not observed in

the longitudinally monitored AA LRS which overall exhibited higher I.I.com.

The data support that the scored signatures captured temporal dynamics of the inflammatory state, as

among T1D progressors (5/5) and HRS showing increases in the number of detected AA specificities

(3/3), there are concordant increases in I.I.com. Regulatory activity was also captured, as the majority of

AA+ HRS showing transient AA positivity or decreasing numbers of detected AA specificities, and

most AA HRS, exhibited concordant decreases in I.I.com.; this observation supports the hypothesis that

among sibling nonprogressors possessing highrisk HLA haplotypes, immunoregulation becomes

temporally more robust.

Increased activated Treg percentages are associated with immunoregulation temporally measured in plasma induced signatures

Human CD4+FoxP3+ T cells can be divided into three functionally distinct subpopulations based on

expression of CD45RA and the level of FOXP3. CD4+/CD45RA/FoxP3high cells are activated Tregs

with high suppressive capacity; CD4+/CD45RA+/FoxP3low cells are resting Tregs also possessing suppressive function; and CD4+/CD45RA/FoxP3low identify nonsuppressive FoxP3+ T cells that can produce proinflammatory cytokines (33). For subjects where cryopreserved PBMC were available, we longitudinally examined the frequency of activated and resting Treg in the periphery of T1D progressors,

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AA+ HRS, AA HRS, and AA LRS subjects that had been analyzed by plasma induced signature

analysis (Figure 7A).

T1D progressor D and AA+ HRS subjects A, B, and C, whose temporally plotted I.I.com exhibited

positive slopes, indicating increasing inflammatory bias, showed percentages of activated Tregs that had

a flat or downward trend over time (Figure 7B). AA+ HRS subject F, sampled annually over ~4 years,

did not fit this pattern, exhibiting a maximal I.I.com at time point 3, but with transient positivity for AA,

consistent with increasing activated Treg percentages during the 3rd through 4th visits (Figure 7B).

Among the AA+ HRS subjects (E, G, I, J) whose temporally plotted I.I.com showed negative slopes

indicating increasing regulatory bias, the percentages of activated Tregs were higher and exhibited a

robust upward trend (Figure 7C). A significant negative relationship between I.I.com and the percentage

of activated Treg for these subjects was observed (R2=0.48, p=0.02).

The AA HRS (I, J, K), also exhibited negative slopes to their temporally plotted I.I.com. Although the

increase in activated Treg percentage was not as robust as that seen in the AA+ HRS (Figure 7C), again

a significant negative relationship between I.I.com and the percentage of activated Treg for these subjects

2 was observed (Figure 7D, R =0.46, p=0.04). These results indicate that temporal decreases in I.I.com are

associated with increased percentages of activated Treg in the periphery. This relationship was not

observed for the LRS subjects (B, D, E) analyzed.

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DISCUSSION

Through analyses of LRS, RO T1D, HRS and uHC subjects, our findings suggest that an innate

inflammatory state exisits in T1D families that is independent of HLA type, AA status, and disease progression. Using novel ontologybased signature scoring, temporal increases in inflammatory processes with concurrent reductions in immunoregulatory activity were measured in T1D progressors.

Among AA HRS and AA+ HRS showing decreases in the number of detected AA specificities,

temporal induction of an IL10/TGFβ–dependent signature was concomitant with increased percentages

of activated peripheral Treg cells. These data suggest that in the presence of high risk HLA haplotypes

the innate inflammatory state common to T1D family members becomes more actively regulated in an

age dependent manner, possibly providing insight as to why T1D susceptibility declines with age.

The bioinformatic strategies, receptor modulations, and cytokine measurements support a decreasing

inflammatory bias (involving at least IL1) and an increasing regulatory bias (involving at least IL10

and TGFβ) when examining the LRS→RO T1D→HRS→uHC continuum (Figure 1). There is

inconsistent literature describing plasma cytokine levels in T1D. This stems from, but is not limited to,

differences in the analytes measured and methods/reagents employed. Furthermore, few studies have

included both related and unrelated AA healthy controls. Consistent with studies that referenced uHC

(34, 35), we observed elevated cytokine levels in T1D families. Specifically, increased plasma IL1α,

IL12p40, CCL2, CCL3 and CCL4 levels were detected in RO T1D, HRS and LRS relative to uHC.

Like Svensson et al., (36) we found differences in plasma cytokine levels between RO T1D patients and

their healthy AA siblings negligible. Consistent with the signature analysis, plasma cytokine levels also

indicated an inflammatory state in T1D families. However, unlike the signature analysis, which reflects

a response to the sum of plasmaborne factors, the cytokine panel tested could not differentiate the T1D

family cohorts.

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The inflammatory state in T1D families may arise from inheritance of potentiating genetic variants in

immune pathways. This is supported by the association of polymorphisms in PTPN22, CTLA4, IL2RA,

IFIH1, SH2B3, and other nonMHC loci with T1D (1). Another potential contributor is intestinal hyper

permeability, which could result in translocation of bacteria and/or PRR ligands and an elevated

inflammatory state. Studies have linked intestinal permeability and intestinal ultrastructure alterations

with T1D (3740). Furthermore, zonulin, a protein that modulates intestinal permeability was found

elevated and associated with increased intestinal permeability in T1D patients and their healthy relatives

(41). Our seminal report focused on IL1 as a mediator of the RO T1D signature (10), a conclusion

supported by this report. However, TLR signaling could also contribute to inflammatory components of

the RO T1D, HRS and LRS signatures. While measurable endotoxin levels were not detected in the

T1D family cohorts (data not shown) we cannot exclude this possibility.

The DR3 and DR4 HLA haplotypes are associated with many autoimmune diseases (42). This stems

from the evolutionarily selected capacity of the DR3/DQ2 and DR4/DQ8 peptides to present a broad

range of pathogenderived peptides to T cells, which is associated with an increased propensity to

present selfpeptides to autoreactive T cells (43). Previous studies did not detect altered Treg

frequencies in T1D patients (44). In this study, amongst AA+ HRS subjects showing robust induction

of the IL10 and TGFβ dependent HRS signature, we observed temporal increases in the percentage of

activated Tregs associated with decreases in the number of detected AA specificities. Negative slopes in

I.I.com were observed in 83% of AA HRS, where increased regulatory activity was also associated with

increased activated Treg percentages in peripheral blood. Our findings support the hypothesis that an

innate inflammatory state exists in T1D families that is actively regulated in the context of highrisk

HLA haplotypes through increased activity/frequency of immunoregulatory cells over time. Exposure

of Tregs to inflammatory inputs (e.g. endotoxin, IL1β) can impair their suppressive capacities by

promoting FOXP3 protein proteosomal degradation (45, 46). It is therefore possible to envision that the

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addition of inflammatory stimuli, such as viral infection, to this preexisting inflammatory environment

might overwhelm an emerging state of regulated susceptibility, promoting a break in tolerance and

autoimmunity.

Besides AA+ relatives of T1D patients that never develop overt diabetes, studies of human subjects

and rodent models support the existence of mechanisms that control progression of autoimmunity in the

context of high genetic risk. AA firstdegree relatives of T1D patients have been reported to have a balance of islet antigen specific inflammatory and regulatory T cells intermediate to that of RO T1D patients and uHC (47). Furthermore, IL10secreting, islet autoAgspecific Treg have been isolated

from subjects with no family history of T1D (48). Similar to the regulated susceptibility observed in

HRS, we have identified temporal induction of an immunoregulatory state in the BioBreeding (BB)DR

rat that supplants a preexisting innate inflammatory state (25). Importantly, establishment of this

regulated state coincides with the failure of Kilham’s rat virus to induce T1D in older BBDR rats, again

suggesting a mechanism for why T1D susceptibility declines with age. As observed in the BB rat (49), pharmacological strategies targeting the preexisting inflammatory state in T1D families may be useful as

a component of preventative or interventional immunotherapy. Such approaches in younger at risk

subjects may only be temporarily necessary until endogenous regulatory mechanisms become

sufficiently established.

This study extends our use of plasmainduced transcription as a tool for understanding, and as a biomarker of, processes associated with T1D pathogenesis. We identified an inflammatory state in T1D

families and the emergence of an agedependent immuneregulated state in HRS. In many respects, the

RO T1D signature represents an intermediate between the LRS and HRS signatures. Since the majority

of siblings that progress to T1D possess DR3 and/or DR4 haplotypes, this intermediate signature raises

the question whether T1D arises from a loss of the HRS regulatory state or a failure to initially establish

it. It is from this perspective that we are extending this modestly sized analysis to largerscale human

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longitudinal studies aimed at assessing the inflammatory state associated with diabetes susceptibility and

disease progression.

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Acknowledgments. The authors thank the patients and subjects who participated in this study as well as

the physicians, nurses and staff of Children’s Hospital of Wisconsin and The Max McGee National

Research Center for Juvenile Diabetes who assisted in subject recruitment and sample

collection/processing.

Funding. This work was supported by the Juvenile Diabetes Research Foundation International (grants

120081026, 52012220, 172012621 to MJH); American Diabetes Association (grant 712BS075 to

MJH); National Institutes of Health (grants R00DK077443 to YGC, R01DK080100 to XW,

R01AI078713 to MJH, DP3DK098161 to CJG/MJH and 1UL1RR031973 The Clinical and

Translational Science Institute Southeast Wisconsin); and The Children’s Hospital of Wisconsin

Foundation.

Duality of Interest. No potential conflicts of interest to this article were reported.

Author Contributions. Y.G.C. designed experiments, researched data, and wrote, reviewed, and edited manuscript; S.M.C. and J.E.W. designed experiments, researched data, and reviewed manuscript; J.K.,

M.L.K., R.G., and M.F.R. recruited subjects, processed samples, researched data, and reviewed manuscript; S.J. and S.C. developed/tested algorithms, conducted data analysis and reviewed manuscript;

C.J.G. wrote, reviewed, and edited manuscript; X.W. designed, supervised/reviewed data analysis, and reviewed manuscript; M.J.H. designed experiments, analyzed data, wrote, reviewed, and edited manuscript. M.J.H is the guarantor of this work and, as such, had full access to all the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.

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19. Atkinson, M.A., and Eisenbarth, G.S. 2001. Type 1 diabetes: new perspectives on disease pathogenesis and treatment. Lancet 358:221229. 20. Devendra, D., Liu, E., and Eisenbarth, G.S. 2004. Type 1 diabetes: recent developments. Bmj 328:750754. 21. Skyler, J.S. 2007. Prediction and prevention of type 1 diabetes: progress, problems, and prospects. Clin Pharmacol Ther 81:768771. 22. Kaldunski, M., Jia, S., Geoffrey, R., Basken, J., Prosser, S., Kansra, S., Mordes, J.P., Lernmark, A., Wang, X., and Hessner, M.J. 2010. Identification of a seruminduced transcriptional signature associated with type 1 diabetes in the BioBreeding rat. Diabetes 59:23752385. 23. Jia, S., Kaldunski, M., Jailwala, P., Geoffrey, R., Kramer, J., Wang, X., and Hessner, M.J. 2011. Use of transcriptional signatures induced in lymphoid and myeloid cell lines as an inflammatory biomarker in Type 1 diabetes. Physiol Genomics 43:697709. 24. Levy, H., Wang, X., Kaldunski, M., Jia, S., Kramer, J., Pavletich, S.J., Reske, M., Gessel, T., Yassai, M., Quasney, M.W., et al. 2012. Transcriptional signatures as a diseasespecific and predictive inflammatory biomarker for type 1 diabetes. Genes Immun 13:593604. 25. Chen, Y.G., Mordes, J.P., Blankenhorn, E.P., Kashmiri, H., Kaldunski, M.L., Jia, S., Geoffrey, R., Wang, X., and Hessner, M.J. 2013. Temporal induction of immunoregulatory processes coincides with agedependent resistance to viralinduced type 1 diabetes. Genes Immun. 26. Alberti, K.G., and Zimmet, P.Z. 1998. Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus provisional report of a WHO consultation. Diabet Med 15:539553. 27. Woo, W., LaGasse, J.M., Zhou, Z., Patel, R., Palmer, J.P., Campus, H., and Hagopian, W.A. 2000. A novel highthroughput method for accurate, rapid, and economical measurement of multiple type 1 diabetes autoantibodies. J Immunol Methods 244:91103. 28. Klitz, W., Maiers, M., Spellman, S., BaxterLowe, L.A., Schmeckpeper, B., Williams, T.M., and FernandezVina, M. 2003. New HLA haplotype frequency reference standards: highresolution and large sample typing of HLA DRDQ haplotypes in a sample of European Americans. Tissue Antigens 62:296307. 29. Huang da, W., Sherman, B.T., and Lempicki, R.A. 2009. Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nat Protoc 4:4457. 30. Sturn, A., Quackenbush, J., and Trajanoski, Z. 2002. Genesis: cluster analysis of microarray data. Bioinformatics 18:207208. 31. Edgar, R., Domrachev, M., and Lash, A.E. 2002. Gene Expression Omnibus: NCBI gene expression and hybridization array data repository. Nucleic Acids Res 30:207210. 32. Aly, T.A., Ide, A., Humphrey, K., Barker, J.M., Steck, A., Erlich, H.A., Yu, L., Miao, D., Redondo, M.J., McFann, K., et al. 2005. Genetic prediction of autoimmunity: initial oligogenic prediction of antiislet autoimmunity amongst DR3/DR4DQ8 relatives of patients with type 1A diabetes. J Autoimmun 25 Suppl:4045. 33. Miyara, M., Yoshioka, Y., Kitoh, A., Shima, T., Wing, K., Niwa, A., Parizot, C., Taflin, C., Heike, T., Valeyre, D., et al. 2009. Functional delineation and differentiation dynamics of human CD4+ T cells expressing the FoxP3 transcription factor. Immunity 30:899911. 34. Chatzigeorgiou, A., Harokopos, V., MylonaKaragianni, C., Tsouvalas, E., Aidinis, V., and Kamper, E.F. 2010. The pattern of inflammatory/antiinflammatory cytokines and chemokines in type 1 diabetic patients over time. Ann Med 42:426438. 35. Hussain, M.J., Maher, J., Warnock, T., Vats, A., Peakman, M., and Vergani, D. 1998. Cytokine overproduction in healthy first degree relatives of patients with IDDM. Diabetologia 41:343349. 36. Svensson, J., Eising, S., Hougaard, D.M., Mortensen, H.B., Skogstrand, K., Simonsen, L.B., Carstensen, B., Nilsson, A., Lernmark, A., Pociot, F., et al. 2012. Few differences in cytokines

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between patients newly diagnosed with type 1 diabetes and their healthy siblings. Hum Immunol 73:11161126. 37. Carratu, R., Secondulfo, M., de Magistris, L., Iafusco, D., Urio, A., Carbone, M.G., Pontoni, G., Carteni, M., and Prisco, F. 1999. Altered intestinal permeability to mannitol in diabetes mellitus type I. J Pediatr Gastroenterol Nutr 28:264269. 38. Kuitunen, M., Saukkonen, T., Ilonen, J., Akerblom, H.K., and Savilahti, E. 2002. Intestinal permeability to mannitol and lactulose in children with type 1 diabetes with the HLADQB1*02 allele. Autoimmunity 35:365368. 39. Bosi, E., Molteni, L., Radaelli, M.G., Folini, L., Fermo, I., Bazzigaluppi, E., Piemonti, L., Pastore, M.R., and Paroni, R. 2006. Increased intestinal permeability precedes clinical onset of type 1 diabetes. Diabetologia 49:28242827. 40. Secondulfo, M., Iafusco, D., Carratu, R., deMagistris, L., Sapone, A., Generoso, M., Mezzogiomo, A., Sasso, F.C., Carteni, M., De Rosa, R., et al. 2004. Ultrastructural mucosal alterations and increased intestinal permeability in nonceliac, type I diabetic patients. Dig Liver Dis 36:3545. 41. Sapone, A., de Magistris, L., Pietzak, M., Clemente, M.G., Tripathi, A., Cucca, F., Lampis, R., Kryszak, D., Carteni, M., Generoso, M., et al. 2006. Zonulin upregulation is associated with increased gut permeability in subjects with type 1 diabetes and their relatives. Diabetes 55:1443 1449. 42. Gough, S.C., and Simmonds, M.J. 2007. The HLA Region and Autoimmune Disease: Associations and Mechanisms of Action. Curr Genomics 8:453465. 43. Mangalam, A.K., Taneja, V., and David, C.S. 2013. HLA class II molecules influence susceptibility versus protection in inflammatory diseases by determining the cytokine profile. J Immunol 190:513518. 44. Brusko, T., Wasserfall, C., McGrail, K., Schatz, R., Viener, H.L., Schatz, D., Haller, M., Rockell, J., Gottlieb, P., ClareSalzler, M., et al. 2007. No alterations in the frequency of FOXP3+ regulatory Tcells in type 1 diabetes. Diabetes 56:604612. 45. van Loosdregt, J., Fleskens, V., Fu, J., Brenkman, A.B., Bekker, C.P., Pals, C.E., Meerding, J., Berkers, C.R., Barbi, J., Grone, A., et al. 2013. Stabilization of the Transcription Factor Foxp3 by the Deubiquitinase USP7 Increases TregCellSuppressive Capacity. Immunity 39:259271. 46. Chen, Z., Barbi, J., Bu, S., Yang, H.Y., Li, Z., Gao, Y., Jinasena, D., Fu, J., Lin, F., Chen, C., et al. 2013. The ubiquitin ligase stub1 negatively modulates regulatory T cell suppressive activity by promoting degradation of the transcription factor foxp3. Immunity 39:272285. 47. Petrich de Marquesini, L.G., Fu, J., Connor, K.J., Bishop, A.J., McLintock, N.E., Pope, C., Wong, F.S., and Dayan, C.M. 2010. IFNgamma and IL10 isletantigenspecific T cell responses in autoantibodynegative firstdegree relatives of patients with type 1 diabetes. Diabetologia 53:14511460. 48. Tree, T.I., Lawson, J., Edwards, H., Skowera, A., Arif, S., Roep, B.O., and Peakman, M. 2010. Naturally arising human CD4 Tcells that recognize islet autoantigens and secrete interleukin10 regulate proinflammatory Tcell responses via linked suppression. Diabetes 59:14511460. 49. Yang, C., Jurczyk, A., Diiorio, P., Norowski, E., Brehm, M.A., Grant, C.W., Guberski, D.L., Greiner, D.L., and Bortell, R. 2013. Salicylate Prevents VirusInduced Type 1 Diabetes in the BBDR Rat. PLoS ONE 8:e78050.

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Table 1. Upstream Regulator Analysis using IPA. Analysis was performed on each of the 6 pairwise comparisons between the four cohorts, as well as for the probe sets most distinctly regulated by each cohort. Indicated are the number of regulated probe sets in the analysis and the upstream regulator. The p‐value (determined with a Fisher’s Exact Test) reflects the significance of the overlap between the regulated probe sets within the data set and genes regulated by the transcriptional regulator. *ns, not significant p>0.05. Arrowup or arrowdown denotes the direction of enrichment in the comparison.

Values <0.01 are considered significant.

Upstream Regulator Data Set n= IL1 IL10 TGFβ RO T1D:uHC 762 3.2 E6 (↑) 1.3 E9 (↓) 1.3 E7 (↓) RO T1D: HRS 261 1.7 E2 (↑) ns* 6.3 E7 (↓) RO T1D:LRS 468 4.4 E2 (↓) 5.0 E2 (↑) ns HRS:LRS 621 5.8 E5 (↓) 4.0 E5 (↑) 3.6 E9 (↑) HRS:uHC 635 ns ns ns LRS:uHC 1339 1.6 E12 (↑) 1.8 E22 (↓) 5.7 E17 (↓) LRS 575 3.6 E8 (↑) 7.5 E14 (↓) 2.6 E8 (↓) RO T1D 128 ns ns ns HRS 156 ns ns 9.7 E3 (↑) uHC 647 6.8 E5 (↓) 5.8 E6 (↑) 1.3 E4 (↑)

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Figure 1. Crosssectional comparisons of the plasma induced signatures. The analysis included RO

T1D patients (n=47; age 10.0±2.9 years; blood glucose=155.0±73.6 mg/dl; HgA1c: %=7.5±1.2; 58±9.3

mmol/mol), LRS (n=42, age 8.4±2.0 years; blood glucose=93.5±16.2 mg/dl), HRS (n=30, age 8.6±1.9

years; blood glucose=92.7±11.7 mg/dl) and uHC (n=44, mean age 15.0±4.1 years; blood

glucose=92.2±13.2 mg/dl). A. Venn diagram illustrating the relationship of the 1,383 probe sets

regulated to thresholds (|log2 ratio|>0.263, 1.2fold; FDR<0.2; ANOVA p<0.036) in the RO T1D:HRS

n=261; RO T1D:LRS n=468; RO T1D:uHC n=762 comparisons. B. Twoway hierarchical clustering

(probe sets and cohorts) for the 1,383 regulated probe sets identified when comparing the RO T1D

patients to the three healthy control cohorts. C. Twoway hierarchical clustering (probe sets and cohorts)

for the 2,422 regulated probe sets identified among all possible pairwise comparisons between the RO

T1D, LRS, HRS and uHC cohorts (n=6 comparisons: RO T1D:HRS n=261; RO T1D:LRS n=468; RO

T1D:uHC n=762; LRS:uHC n=1,339; LRS:HRS n=612; HRS:uHC n=635). D. Venn diagram

illustrating the relationship of the 1,374/2,422 probe sets remaining after identification of the most

distinctive probe sets for each cohort. This was accomplished by filtering the 2,422 probe set to retain

those probe sets where the difference in the mean induction for 1 group was >│1.125fold│relative to

the mean of each of the other 3 groups. E. Heat maps illustrating the mean expression levels of probe

sets that distinguish each cohort (leftmost panel); shown are the expression levels for these genes by the

individual subjects comprising each cohort (rightmost panels, as indicated). Expression levels

illustrated in the heat map are normalized against the mean expression of the four cohorts.

Figure 2. Expression levels and oneway hierarchical clustering (probe sets only) of selected probe sets

regulated by LRS, RO T1D, HRS and uHC plasma (among the 1,374 probe sets identified in Figure 1D

and 1E). Tabulated are the fold of change and FDR associated with each probe set for the six possible

pairwise comparisons between the cohorts. a, b, and c denote regulation by IL1, TGFβ, and IL10,

For Peer Review Only Diabetes Page 24 of 65

respectively, per IPA upstream regulator analysis. Expression levels illustrated in the heat map are normalized against the mean expression of the four cohorts.

Figure 3. Identification of ligands underlying plasma induced signatures. A. Adding 4 ug/ml IL1RN to

RO T1D cultures (n=47 subjects) modulated IL1 dependent components of the RO T1D:uHC signature, directionally altering expression of 583/762 genes (76.5%, X2 p<10E6; yellow box). Notably, among

the 2,422 union of probe sets regulated across the six possible pairwise cohort comparisons, 1449/2,422

(59.8%, X2 p<1.13E04) reversed the direction of induction when IL1RN was introduced into the RO

T1D coculture further supporting an IL1 bias in T1D families. B: 612 significantly regulated genes were identified when directly comparing the LRS and HRS cohorts; 59.5% (n=364) were among the

1,383 gene union in shown Figure 1B. Adding 30g/ml αTGFβ receptor and 30g/ml αIL10 receptor neutralizing Abs to HRS sera (n=3 subjects) modulated transcription to mimic LRS sera, directionally altering expression of 549/612 genes (89.7%, X2 p<10E6; yellow box). Tabulated are the fold of change and FDR associated with each probe set for the six possible pairwise comparisons between the cohorts. a, b, and c denote regulation by IL1, TGFβ, and IL10, respectively, per IPA

upstream regulator analysis. Nonspecific isotypic control Ab did not modulate expression (data not

shown). Independent addition of αTGFβ receptor or αIL10 receptor neutralizing Abs to HRS sera

(n=3 subjects) modulated fewer genes (511/612 and 425/612, respectively, X2 p<10E3). Adding 2ng/ml

TGFβ and 5ng/ml IL10 to LRS sera (n=3 subjects) modulated transcription to mimic HRS sera,

directionally altering expression of 361/612 (59.0%, X2 p=0.048) genes. Independent addition of TGFβ or IL10 to LRS sera modulated fewer genes (170/612 and 207/612, respectively, X2 p>0.05, data not

shown).

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Figure 4. Plasma IL1α, IL12p40, CCL2, CCL3, and CCL4 levels in the crosssectional cohorts. 30

LRS, 48 RO T1D, 30 HRS, and 31 uHC subjects were assayed in duplicate; respectively 28, 31, 28 and

22 of these subjects were analyzed in the expression studies. 1Tabulated data are expressed as cohort

mean values ± standard error in pg/ml. 2pvalue for two sample ttest. ▼=LRS, ●=RO T1D, ▲=HRS,

■=uHC, open symbols are below assay detection limit. Among the LRS, RO T1D, HRS and uHC

cohorts, respectively: 80.0%, 81.3%, 83.3%, and 22.6% of subjects had IL1α levels >16 pg/ml

detection limit; 56.7%, 81.3%, 60.0%, and 29.0% of subjects had IL12p40 levels >25 pg/ml detection

limit; all subjects had CCL2 levels >16 pg/ml detection limit; 63.3%, 66.7%, 56.7%, and 6.5% of

subjects had CCL3 levels >25 pg/ml detection limit; and 93.3%, 87.5%, 100%, and 64.5% of subjects

had CCL4 levels >16 pg/ml detection limit. The average blood glucose measurements (nonfasting) for

these LRS, RO T1D, HRS and uHC cohorts were 93.1±12.0 mg/dl; 166.4±69.9 mg/dl; 91.6±10.6 mg/dl;

and 89.0±10.3 mg/dl, respectively. While blood glucose levels were higher in the RO T1D cohort, these

cytokines were also significantly elevated in the LRS and/or HRS cohorts, suggesting that the elevated

cytokine levels are not related to hyperglycemia. Eotaxin, GMCSF, IFNα2, IFNγ, IL1β, IL2, IL3, IL

4, IL5, IL6, IL7, IL8, IL10, IL12p70, IL13, IL15, IL17A, IP10, TNFα and TNFβ were

included in the 25plex panel but differences between the cohorts were not detected.

Figure 5. Longitudinal analyses of T1D progressors and siblings of T1D probands. In all cases ≥4

samplings per subject were available, spanning a time period of 2.610 years. A. Analysis from the

perspective of the 1,374 regulated transcripts identified in crosssectional studies. Inflammatory activity

was associated with probe sets upregulated by LRS and RO T1D plasma and downregulated by HRS

and uHC plasma; while regulatory activity was associated with probe sets downregulated by LRS and

RO T1D plasma and upregulated by HRS and uHC plasma. These inflammatory and regulatory probe

sets are indicated by I and R, respectively. Presented are the mean responses for each crosssectional

cohort (leftmost panel) and 8 longitudinal data sets, T1D progressors A and B; AA+ HRS C and E, AA 25

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HRS I and K, and AA LRS C and D (as labeled). Indicated for the T1D progressors is the time of

sample collection relative to T1D onset. Progressor A and D were diagnosed at the ages of 21 and 17,

respectively. For nonprogressors, the age of sample collection is indicated. The number of detected AA

specificities is indicated (04). B. Expression levels of 30 well annotated regulated transcripts having

inflammatory and regulatory roles. The crosssectional data set to which each probe set is associated

(LRS, RO T1D, HRS, uHC) is indicated (a, b, c, d, respectively).

Figure 6. Ontologybased scoring of crosssectional and longitudinal samples (≥4 samplings/subject).

As indicated in Figure 5, inflammatory activity was associated with probe sets upregulated by LRS and

RO T1D plasma and downregulated by HRS and uHC plasma; while regulatory activity was associated

with probe sets downregulated by LRS and RO T1D plasma and upregulated by HRS and uHC plasma.

This formed the basis of an composite Inflammatory Index (I.I.com), determined by calculating an

average ratio between the mean log intensity of the inflammatory genes vs the mean log intensity of the

regulatory genes of the four crosssectional data subsets. Given their relevance, higher weight was

ascribed to probe sets of the RO T1D (13.0) and HRS (11.5) cohorts. A. The mean composite I.I.com of

the 47 crosssectional RO T1D subjects (0.42±0.07, mean±SE) was significantly higher than that

observed for the 42 LRS (0.17±0.06), 30 HRS (0.18±0.10) and 44 uHC (0.00±0.06) subjects (p=0.007,

2.6E06, and 7.8E06, respectively). The mean I.I.com of the LRS versus HRS and LRS versus uHC

cohorts were also significantly different (p=0.002 and 0.036, respectively). The mean I.I.com of the HRS

versus uHC was not significantly different (p=0.11). Panels BE, each point is a sampling and each line

is a longitudinal series. B. Longitudinal analysis of progressors to T1D (n=5); subjects A, B, E, F and D

were diagnosed at the ages of 21.7, 9.0, 19.3, 6.9, and 17.4, respectively. Indicated are the time of

sampling relative to onset and the number of detected AA specificities (04). Postonset time points are boxed. C. Longitudinal analysis of presently nondiabetic, AA+ HRS (n=9). Indicated are the age and 26

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AA status at each sampling. D. Longitudinal analysis of healthy AA HRS (n=12). Indicated is the age

at each sampling. E. Longitudinal analysis of healthy AA LRS (n=6). Indicated is the age at each

sampling. Analysis and regressions were conducted in MatLab.

Figure 7. Longitudinal analysis of activated and resting Treg cell abundances in peripheral blood of

T1D family members. A. Representative flow cytometry profiles showing the gating strategy for resting

and activated Treg populations. Resting and activated CD4+ Tregs were respectively defined as

CD45RA+/FoxP3low and CD45RA/FoxP3high. The expression CD45RO andCD25confirmed the

phenotype of resting (CD45RO/ CD25+) and activated (CD45RO+/ CD25high) Tregs. Both populations

were mostly CD127low, further excluding them as effector T cells B. Analysis of a T1D progressor and

AA+ HRS possessing temporally measured I.I.com possessing positive slopes. C. Analysis of AA+ HRS

possessing temporally measured I.I.com possessing negative slopes. D. Analysis of AA HRS and AA

LRS. In BD, the left panel plots the percentage of CD4+/CD45RA/FoxP3high Treg among total Treg

versus time for each subject; the right panel plots I.I.com versus the percentage of CD4+/CD45RA

/FoxP3high Treg among total Treg for each subject. The regression is plotted for all samples in the

analysis (solid line); the dotted line (Panel D) shows the regression for only the AAHRS subjects I, J,

and K.

For Peer Review Only A. B. C.Diabetes D. Page 28 of 65 RO T1D:uHC RO T1D:HRS n=762 n=261 RO T1D HRS n=128 n=156 LRS uHC 128 678 42 195 n=575 80 n=647 10 6 4 3 36 18 490 0 0 544 408

RO T1D:LRS 0 Union: n=1,383 n=468 15 34 0 0 66 -2 Fold of Change +2 Union n=1,374

Union: n=2,422 E. LRS RO T1D HRS uHC n=42 subjects n=47 subjects subjects n=30 subjects n=44

LRS n=575 n=138↑; 437↓

RO T1D n=128 n=36↑; 92↓ HRS n=156 n=84↑; 72↓

uHC n=647 n=532↑; 115↓

For Peer Review Only Page 29 of 65 ComparisonDiabetes (Fold of Change; FDR) Gene ID RO T1D:uHC RO T1D:HRS RO T1D:LRS HRS:LRS HRS:uHC LRS:uHC CXCL6 a -2.5, 0.08 2.6, 0 CCL7 a, c -2.1, 0.1 2.1, 0.01 CD14 a, b, c 1.7, 0.16 -2.2, 0.13 2.3, 0.01 THBD a, c 1.6, 0.19 -2.1, 0.12 2.2, 0.01 CXCL16 -1.3, 0.12 1.4, 0 CCL4 a, b, c -1.2, 0.19 1.4, 0 SUZ12 1.2, 0 -1.2, 0 SMARCA4 -1.2, 0 LRS SMAD5 1.3, 0 NRIP1 1.2, 0.01 1.2, 0.06 PTPRC c 1.2, 0.06 1.3, 0.05 NCOA3 c 1.2, 0 BCL2 1.3, 0 1.3, 0 -1.3, 0 SMAD9 -1.3, 0 EGR1 a, c -1.4, 0.02 RHOH 1.2, 0.1 1.3, 0.09 -1.4, 0 GIMAP5 1.5, 0 1.4, 0.04 -1.3, 0.01 Klf12 -1.3, 0.03 -1.4, 0.1 -1.3, 0.13 RNF125 -1.4, 0.03 -1.3, 0.06 CBLB -1.3, 0.01 -1.2, 0.02 ZNF146 a -1.5, 0.04 DDX52 -1.4, 0.01 XRCC6 -1.3, 0.02 HEXIM2 c -1.3, 0.08 PIAS1 -1.3, 0.06 CLN8 -1.3, 0.02 ZNF224 -1.3, 0.02 RO T1D LASS6 -1.3, 0 HELB -1.2, 0.03 SPRY2 1.5, 0.08 -1.3, 0.16 CD109 1.3, 0.09 PTEN c 1.3, 0.09 NRP2 1.3, 0.03 1.3, 0.11 1.2, 0.14 ZNF709 1.2, 0.03 1.3, 0.07 ZNF643 1.2, 0.04 BACH1 1.2, 0 TCF7L2 1.2, 0.01 TRIO 1.3, 0.01 WAC 1.3, 0.06 1.4, 0.03 ANXA1 a 1.5, 0.04 1.4, 0.1 ADAM9 -1.4, 0.19 1.2, 0.17 MTSS1 -1.3, 0.11 NPFF -1.2, 0.01 ZNF800 1.4 0 MATR3 -1.2, 0.18 1.3, 0.05 MYSM1 1.3, 0.01 1.2, 0.04 ZEB1 c 1.2, 0.01 HSPD1 -1.2, 0.04 1.2, 0.03 1.2, 0.02 HTATSF1 HRS 1.2, 0.16 1.2, 0.08 IL2RA a, c 1.2, 0.14 1.2, 0.04 ERAP1 1.3, 0.14 1.3, 0.08 CD37 -1.2, 0.05 FYB -1.3, 0.02 RAD21 c -1.2, 0.04 1.2, 0.02 NCOA2 a 1.3, 0.13 1.3, 0.02 CFL1 c -1.3, 0.1 1.3, 0.02 BCL11B 1.3, 0.09 TRAF4 1.3, 0.02 PTGES a, c 1.4, 0.05 1.6, 0 FCER1G b, c 1.3, 0.1 1.4, 0 GNLY 1.2, 0.01 1.3, 0.01 1.3, 0 ARIH1 -1.6, 0.02 -1.3, 0.16 PPM1K -1.4, 0.01 -1.3, 0.12 -1.2, 0.1 SMURF1 c -1.3, 0.04 -1.3, 0.07 uHC CUL4A -1.4, 0.03 -1.3, 0.1 -1.2, 0.13 PPP3CA -1.4, 0.05 UBR2 -1.3, 0.04 -1.3, 0.13 SSH2 -1.2, 0.01 NSMCE2 -1.4, For0.04 Peer Review Only -1.2, 0.16 SKIL c -1.4, 0.02 -2 Fold of Change +2 -1.5, 0 A Diabetes Page 30 of 65

Comparison (Fold of Change; FDR) Gene ID RO T1D:uHC RO T1D:HRS RO T1D:LRS HRS:LRS HRS:uHC LRS:uHC PTGS2 a,b,c 1.4, 0.15 1.4, 0.13 CXCL1 a,c 1.5, 0.09 -1.5, 0.15 -1.9, 0.05 2.3, 0 CXCL3 a,b,c 1.4, 0.06 -1.3, 0.12 -1.6, 0.04 1.9, 0 CXCL2 a,b,c 1.2, 0.09 -1.3, 0.08 1.4, 0 TNFAIP6 a,c 1.2, 0.17 1.4, 0.01 IL1B a,b,c 1.2, 0.1 -1.2, 0.19 -1.3, 0.12 1.5, 0 NLRP3 1.3, 0.02 -1.3, 0.02 1.5, 0 XCL1 b 1.2, 0.01 1.3, 0 RHOU 1.3, 0.08 -1.4, 0.14 1.4, 0.01 SLC39A8 1.3, 0.02 1.3, 0.18 -1.3, 0.08 1.4, 0 PLAUR 1.3, 0.01 1.3, 0.11 -1.4, 0.01 1.5, 0 IRAK3 a,c 1.2, 0.01 1.3, 0 MAPK1IP1L 1.2, 0.02 ATM c -1.7, 0.03 -1.4, 0.18 SIAH1 -1.7, 0.01 -1.4, 0.13 -1.4, 0.09 PDP2 -1.5, 0.04 -1.6, 0.04 -1.6, 0.01 ITCH -1.3, 0.02 -1.3, 0.09 -1.2, 0.1 PPP3CB -1.3, 0.02 -1.2, 0.1 -1.2, 0.02 PTPN4 -1.2, 0.07 -1.3, 0.07 -1.2, 0.04 SMURF2 -1.3, 0.08 -1.3, 0.05 -1.3, 0.04 n=583

-2 Fold of Change +2 n=762 B Comparison (Fold of Change; FDR) Gene ID RO T1D:uHC RO T1D:HRS RO T1D:LRS HRS:LRS HRS:uHC LRS:uHC THBS1 a,c 1.6, 0.09 -1.9, 0.07 2.2, 0 CCL2 a,b,c -2.0, 0.17 2.0, 0.01 TLR2 a,b,c 1.4, 0.06 -1.6, 0.01 1.7, 0 EREG c 1.4, 0.04 1.6, 0.05 -1.6, 0.02 1.4, 0.02 IL1R1 a,b,c 1.4, 0.07 1.6, 0.12 -1.7, 0.02 1.6, 0.01 FCAR c 1.4, 0.18 -1.7, 0.12 1.7, 0.01 HBEGF a,c 1.3, 0.09 -1.4, 0.1 1.5, 0.01 TREM1 a,b 1.3, 0.06 -1.5, 0.03 1.5, 0 CD93 1.5, 0.04 -1.5, 0.13 1.9, 0 NRP1 c 1.5, 0.17 -1.6, 0.15 CCL3 a,b,c -1.3, 0.2 1.4, 0 TFPI 1.3, 0.11 -1.2, 0.17 GREM1 c 1.5, 0.17 1.9, 0.13 -2.1, 0.06 1.7, 0.05 ADM a,b,c 1.3, 0.07 -1.3, 0.03 SCG5 c 1.4, 0.2 -1.5, 0.08 TNS3 1.4, 0.08 -1.4, 0.11 TRIB1 1.2, 0.09 -1.2, 0.12 SKI c -1.3, 0.08 1.2, 0.14 -1.2, 0.14 -1.6, 0 TGFBR2 a,c 1.3, 0 1.3, 0.01 IFI16 c 1.3, 0.02 n=549 TXNIP a,c 1.2, 0.13

n=612 For Peer Review Only Page 31 of 65 Diabetes

2048

1024

512

256

128

Concentration pg/ml 16

1 IL-1α IL-12p40 CCL2 CCL3 CCL4 LRS (pg/ml)1 90.3 ± 19.5 138.2 ± 65.8 245.1 ± 11.9 55.4 ± 12.9 65.5 ± 13.0 RO T1D (pg/ml)1 78.6 ± 10.1 121.1 ± 23.2 249.4 ± 12.5 50.6 ± 6.6 48.3 ± 5.4 HRS (pg/ml)1 82.8 ± 9.7 62.3 ± 11.6 266.2 ± 17.5 56.5 ± 14.0 59.2 ± 8.0 uHC (pg/ml)1 14.6 ± 5.7 33.0 ± 9.2 197.7 ± 14.5 7.2 ± 2.4 21.8 ± 3.1 LRS:uHC (p)2 1.2 E-6 0.004 0.017 1.6 E-6 8.4 E-6 RO T1D:uHC (p)2 3.4 E-8 6.2 E-8 0.014 2.6 E-8 6.2 E-4 HRS:uHC (p)2 4.5 E-7 0.002 0.01 7.2 E-5 3.2 E-6 T1D family:uHC (p)2 1.6 E-10 7.7 E-7 7.30 E-4 7.6 E-9 1.9 E-8 RO T1D:LRS (p)2 n.s. n.s. n.s. n.s. n.s. RO T1D:HRS (p)2 n.s. 0.013 n.s. n.s. n.s. HRS:LRS (p)2 n.s. n.s. n.s. n.s. n.s.

For Peer Review Only Diabetes Page 32 of 65 Progressor Progressor AA+HRS AA+HRS AA-HRS AA-HRS AA-LRS AA-LRS -2 Fold of Change +2 A D C E I K C D time to onset time to onset Age Age Age Age Age Age -7.1 -5.1 -4.1 -3.1 -2.6 -2.0 -1.5 2.1 6.0 7.1 8.0 9.1 11.2 2.2 4.2 5.1 6.5 7.2 8.4 9.8 10.4 12.4 13.4 14.4 15.2 15.9 16.5 4.5 10.0 10.8 11.8 12.9 10.5 12.5 13.6 14.6 15.5 16.5 12.6 13.6 14.6 15.7 16.6 -5.3 -3.3 -2.4 -1.5 -0.3 +0.3 A I R LRS n=575

I RO T1D R n=128

I HRS R n=156

I R

uHC n=647

AA Status 0 1 3 3 3 4 0 0 0 3 3 3 3 1 1 1 2 2 2 2 0 2 1 1 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 B IRAK3b PTGS2d EREGc CXCL1a,d CXCL3a,d IL1Aa,d CCL4a,d CXCL2a

Inflammatory Inflammatory CCL3a TNFAIP6a IL1Ba,d MBNL1b SMURF1d SMCHD1b CBLBb XRCC6b SNRPNb PIGUb POLR2J2b PIAS1b ZBTB11b ESYT2b EEF1Gb Regulatory Regulatory CLN8b PLCL1d LTBP3d SMURF2d STK17Ad SKILd SKId For Peer Review Only Page 33 of 65 Diabetes A B 1.5 2.0 ) 1.5 1.0 com

I.I. 1.0 0.5

0.5 com 0

0 I.I. -0.5 -0.5 -1.0 -1.0 Each interval = 1 year -1.5 InflammatoryIndex ( -1.5

-2.0 Progressor: A B E F D Time to onset: -5.3 - +0.3 -1.5 - +1.1 -6.5 - -1.4 -2.7 - +0.8 -7.0 - +0.2 LRS uHC HRS AA Status: 0,1,3,3,3,4 1,2,3,2 4,3,3,3,3,3,3,1 4,3,4,4,4,4 0,0,0,3,3,3,3,4 1.5 C T1D RO 1.0

0.5

com 0 I.I. -0.5

-1.0 Each interval = 1 year -1.5 AA+ HRS: A B C E F G H I J Age: 14.0-17.1 13.4-19.7 9.2-14.3 12.6-16.6 11.3-14.3 7.3-12.3 12.0-16.9 2.1-9.6 5.4-14.4 AA Status: 4,4,4,4,3 3,2,3,2,3,2,2,2 1,1,1,2,2,2,2 0,2,1,1,1 1,1,0,0 0,0,0,1,0,0 2,2,1,0,0 1,1,2,0,0,0,0,0 1,1,1,0,0,0 1.5 D 1.0

0.5

com 0 I.I. -0.5

-1.0 Each interval = 1 year -1.5 AA- HRS: A J B I C F D K G E H L Age: 10.4-18.9 3.8-11.4 2.2-6.1 2.1-11.2 14.7-18.7 7.3-13.3 14.8-18.4 2.2-9.8 5.5-11.1 7.1-10.1 2.9-9.2 3.1-7.2 1.5 E 1.0

0.5

com 0 I.I. -0.5

-1.0 Each interval = 1 year -1.5 AA- LRS: B C D E F G Age: 5.5-14.3 4.5-12.9 10.5-16.5 6.3-12.4 7.4-11.7 2.6-10.0 For Peer Review Only Diabetes Page 34 of 65

A Resting

Tregs CD4 CD45RA

Live/dead Live/dead Activated Side scatterSide Non Tregs Tregs

Forward scatter Forward scatter Forward scatter FOXP3

80.0 B T1D Progressor D 1.0 ) 70.0 AA+ HRS A com 0.5 60.0 AA+ HRS B I.I. 50.0 AA+ HRS C AA+ HRS F 0 40.0 30.0 -0.5 20.0 -1.0 10.0 2 Inflammatory Index ( Index Inflammatory Percent Activated Treg ActivatedPercent Slope: -0.25; p=0.61; R =-0.11 0 -1.5 0 5 10 15 20 0 20.0 40.0 60.0 80.0 Age (Years) Percent Activated Treg 80.0 AA+ HRS E C 1.0 ) 70.0 AA+ HRS G AA+ HRS I com 60.0 I.I. 0.5 AA+ HRS J 50.0 0 40.0 30.0 -0.5 20.0 -1.0

Percent Activated Treg Activated Percent 10.0 2 Inflammatory Index ( Index Inflammatory Slope: -0.98; p=0.02; R =-0.48 0 -1.5 0 5 10 15 20 0 20.0 40.0 60.0 80.0 Age (Years) Percent Activated Treg 80.0 1.0 D AA- HRS I 70.0 ) AA- HRS J com 60.0 0.5 AA- HRS and AA- LRS AA- HRS K I.I. Slope: -0.61; 50.0 AA- LRS B 0 p=0.48; R2=-0.12 40.0 AA- LRS D AA- LRS E 30.0 -0.5 HRS only 20.0 Slope: -2.95; -1.0 p=0.04; R2=-0.46 10.0 Percent Activated Treg Activated Percent Inflammatory Index ( Index Inflammatory 0 -1.5 0 5 10 15 20 0 20.0 40.0 60.0 80.0 Age (Years) Percent Activated Treg

For Peer Review Only Page 35 of 65 Diabetes

Online Supplemental Data 1

The 1,374 regulated transcripts identified in cross-sectional studies consists of: 1) 575 LRS-associated probe sets where the 138 up-regulated and 437 down-regulated transcripts are annotated as being inflammatory and regulatory, respectively; 2) 128 RO T1D-associated probe sets where the 36 upregulated and 92 down-regulated transcripts are annotated as being inflammatory and regulatory, respectively; 3) 156 HRS-associated probe sets where the 84 up-regulated and 72 down-regulated transcripts are annotated as being regulatory and inflammatory, respectively; and 4) 647 uHC-associated probe sets where the 532 up-regulated and 115 down-regulated transcripts are annotated as being regulatory and inflammatory, respectively (These are Tabulated in Online Supplemental Table 1).

In order to comprehensively measure the inflammatory state, ontology-based inflammatory index (I.I.) algorithms were tested that utilized ratios between the mean log intensity of inflammatory versus regulatory probe sets for each of the cross-sectional data subsets. Scoring strategies utilizing all 1,374 probe sets more effectively separated the four cohorts than ones utilizing smaller data subsets, including the 128 probe sets associated with the RO T1D cohort. Since the majority of siblings that progress to T1D possess DR3 and/or DR4 haplotypes, additional weighting of probe sets associated with the RO T1D and HRS groups was evaluated. While all tested algorithms were able to capture temporal changes in the inflammatory state (see tables below), optimal cross-sectional group separation was observed with the following scoring strategy:

∑ , 1a

Where, is the mean inflammatory activity, relative to uHC, of a given sample associated with the kth-cohort-specific regulated genes (k=1, 2, 3, or 4, representing the LRS, RO T1D, HRS, and uHC

cohorts, respectively). E is the expression (log2 intensity) of the sample. is the mean expression

(log2 intensity) of uHC cohort. is the number of genes associated with inflammatory activity specific th to the k cohort LRS (n1=138), RO T1D (n2=36), HRS (n3=72), uHC (n4=115) as described above and in Figure 5.

∑ , 1b th is the mean regulatory activity, relative to uHC, of a given sample associated with the k -cohort- specific regulated genes (k=1, 2, 3, or 4 representing the LRS, RO T1D, HRS, and uHC cohorts,

For Peer Review Only Diabetes Page 36 of 65

th respectively). is the number of genes associated with regulatory activity specific to the k cohort

LRS (m1=437), RO T1D (m2=92), HRS (m3=84), uHC (m4=532) as described above and in Figure 5.

The I.I. for a sample, based upon each cross-sectional data subset k (. . , is determined by:

. . 2

After which, . ., a composite score for a sample based upon the individual .. for each of the four cross-sectional data subsets is determined by: ∑ ∗ . . . . 3 ∑

Where is the optimized weight for each of the four cross-sectional cohorts, defined by: = [1.0, 13.0, 11.5, 1.0] to ascribe higher weight to genes of the RO T1D and HRS cohorts. It is important to note that for the subjects illustrated in Figure 5, independent evaluation of the slopes associated with IAk and RAk revealed that I.I.com for any given subject was influenced by changes in both inflammatory and regulatory activity; however the relative contribution of each varied between subjects.

For Peer Review Only Page 37 of 65 Diabetes

Supplemental Figure 1. Details parallel those outlined in Figure 5 legend. Longitudinal Progressor Series Longitudinal AA+ HRS Series Longitudinal AA- HRS Series Longitudinal AA- LRS Series A B E F D A B C E F G H I J A B C D E F G H I J K L B C D E F G 21.67 9.02 19.33 6.9 17.38

Age at onset:

6.28 7.30 8.27 9.53 3.05 4.05 6.01 7.16 7.07 8.08 9.08 7.31 9.30 5.46 6.69 7.99 2.58 7.07 7.94 9.97 2.13 5.99 7.13 8.01 9.10 4.53 9.95 2.16 3.07 4.08 6.11 2.20 4.22 5.13 6.49 7.24 8.38 9.76 7.41 8.43 9.39 5.51 8.81 2.86 4.97 6.71 9.24 R O T 1 D 5.35 6.37 7.35 8.35 9.15 9.84 Age: 2.09 2.61 3.22 4.37 5.43 7.84 9.59 8.86 9.99 3.81 5.83 6.75 8.11 Time to onset: 7.31 8.33 9.42 10.08 10.37 15.31 16.50 17.65 18.85 11.15 10.56 11.65 11.07 10.16 10.54 12.53 13.55 14.55 15.54 16.54 14.34 12.35 10.23 11.59 10.32 11.32 12.31 13.31 18.65 14.80 16.36 17.36 18.35 14.67 15.66 16.64 17.67 11.37 12.85 12.58 13.57 14.63 15.67 16.58 12.02 13.84 15.14 16.02 16.91 10.81 11.83 10.45 11.26 10.97 11.49 12.02 12.66 19.71 12.33 12.12 14.44 14.03 15.09 16.02 17.10 19.52 15.78 16.45 17.62 18.73 12.39 13.36 14.03 14.65 14.25 11.29 12.37 13.29 14.27 L R S u H C H R S -6.48 -5.45 -4.29 -3.93 -3.44 -2.42 -1.36 -6.95 -4.95 -3.95 -2.96 -2.47 -1.92 -1.40 +0.17 -0.37 +0.15 +1.09 +0.10 -2.90 -1.50 -2.71 -2.25 -1.47 -0.97 +0.84 -5.32 -3.32 -2.44 -1.47 -0.33 +0.27 +0.57

LRS n=575 1389; 437;

ROT1D n=128

HRS n=156

HC n=647 5329; 115;

AA Status: 0 1 3 3 3 4 4 1 2 3 2 4 3 3 3 3 3 3 1 4 3 4 4 4 4 0 0 0 3 3 3 3 4 4 4 4 4 3 3 2 3 2 3 2 2 2 1 1 1 2 2 2 2 0 2 1 1 1 1 1 0 0 0 0 0 1 0 0 2 2 1 0 0 1 1 2 0 0 0 0 0 1 1 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 IRAK3b PTGS2d EREGc CXCL1a,d CXCL3a,d IL1Aa,d CCL4a,d CXCL2a CCL3a a

Inflammator y TNFAIP6 IL1Ba,d MBNL1b SMURF1d SMCHD1b CBLBb XRCC6b SNRPNb PIGUb POLR2J2b PIAS1b ZBTB11b ESYT2b EEF1Gb CLN8b d Regulatory Regulatory PLCL1 LTBP3d SMURF2d STK17Ad SKILd SKId

For Peer Review Only Diabetes Page 38 of 65 Supplemental TABLE 1 Subject Information Antibody Status (embolded is positive) Serum Signature [S] Number of AddBack detected AA Plasma [A] Positive for AA at specificities Age at Glucose Cytokine One or More Later Sample Identifier Gender HbA1c(%) (0‐4) GAD IA2 IAA ZnT8 Age at Visit Diagnosis (mg/dl) BMI ELISA [C] Time Points Auto‐antibody‐negative (AA‐) Low HLA Risk Siblings (nonDR3 nonDR4) LR135 Male Not tested 0 ‐0.006 ‐0.0017 0 ‐0.0118 9.4575 82 19.1 SC No LR293 Male Not tested 0 0.002 0.0005 0.03 ‐0.0003 8.8466 94 15.5 SC No LR1846 Male Not tested 0 0.0129 ‐0.0007 ‐0.0084 ‐0.013 8.2192 96 15.5 SC No LR1918 Female Not tested 0 0.0082 ‐0.0011 ‐0.0034 ‐0.01 9.0822 94 16.5 SC No LR1922 Male Not tested 0 0.0229 ‐0.0017 0.0065 ‐0.008 7.4521 96 17.0 SC No LR1940 Male Not tested 0 0.0107 0.0003 ‐0.0017 ‐0.011 7.0192 94 16.4 SC No LR1976 Male Not tested 0 0.0075 ‐0.0009 0 ‐0.007 8.0712 83 18.3 SC No LR1982 Female Not tested 0 0.0146 ‐0.0012 0.0027 ‐0.006 6.5589 93 19.1 SC No LR2110 Female Not tested 0 0.005 ‐0.0016 0 ‐0.002 8.7068 107 19.9 SC No LR2138 Male Not tested 0 ‐0.0094 0.0011 0.0115 ‐0.01 7.3178 95 15.9 SC No LR2532 Male Not tested 0 ‐0.0075 ‐0.0018 ‐0.0071 ‐0.0044 8.0027 82 15.0 SC No LR2560 Female Not tested 0 0.0002 ‐0.0017 0.0108 ‐0.0028 9.2932 93 16.0 SC No LR2215 Female Not tested 0 ‐0.0014 ‐0.0021 ‐0.0066 ‐0.01 7.1123 80 15.3 SC No LR2707 Female Not tested 0 ‐0.0002 0 ‐0.003 0.014 6.1945 94 15.9 SC No LR15 Female Not tested 0 0.0059 ‐0.0003 0.0119 ‐0.0099 8.8548 128 18.2 S No LR88 Male Not tested 0 ‐0.0177 0.001 0.009 ‐0.0083 5.5068 91 16.7 SC No LR101 Female Not tested 0 ‐0.0171 ‐0.001 0.0112 ‐0.0098 5.1041 86 17.6 SC No LR342 Female Not tested 0 0.0117 0.0009 0.0033 ‐0.0009 8.1836 96 14.5 SA No LR345 Male Not tested 0 ‐0.002 ‐0.0002 0.0165 0.0019 9.6959 98 15.7 SC No LR356 Male Not tested 0 ‐0.0049 ‐0.0046 0.0025 ‐0.0058 5.3671 98 18.9 S No LR884 Female Not tested 0 ‐0.0071 0.0023 0.0035 ‐0.0058 7.3123 102 15.4 SC No LR890 Male Not tested 0 ‐0.0027 ‐0.0014 ‐0.0017 ‐0.0039 5.7425 158 13.9 S No LR992 Female Not tested 0 ‐0.0032 0.0002 0 ‐0.0075 5.1205 75 16.1 S No LR1050 Female Not tested 0 0.0045 0.0018 0.0031 ‐0.0021 8.2877 95 21.6 SC No LR1226 Female Not tested 0 0.0072 ‐0.0005 ‐0.0154 0.018 9.6849 78 17.3 S No LR1477 Male Not tested 0 0.0028 0.0005 0.0039 ‐0.01 8.8 82 25.5 SC No LR1700 Male Not tested 0 0 ‐0.003 0 ‐0.011 5.4384 90 15.8 S No LR1857 Female Not tested 0 0.0104 ‐0.003 ‐0.0017 ‐0.013 8.3507 106 14.2 S No LR140 Female Not tested 0 ‐0.0006 ‐0.0018 0.01 ‐0.0016 11.5562 79 15.2 SC No LR158 Female Not tested 0 ‐0.0001 ‐0.0001 0.0035 ‐0.0086 11.3589 89 18.0 S No LR1497 Male Not tested 0 0.0116 ‐0.0019 0.0014 ‐0.002 10.537 83 14.5 SC No LR185 Male Not tested 0 0.0068 0.0024 ‐0.0066 ‐0.0112 11.7973 99 30.1 SC No LR1592 Male Not tested 0 0.0584 ‐0.0014 ‐0.0032 ‐0.009 11.5233 89 17.4 SC No LR2091 Female Not tested 0 0.0023 ‐0.0024 0.003 ‐0.002 11.5342 76 19.1 SA No LR2489 Male Not tested 0 ‐0.0074 ‐0.0021 0 ‐0.002 11.2082 84 16.8 S No LR2683 Male Not tested 0 0.0008 ‐0.002 ‐0.0041 ‐0.005 10.7041 85 15.5 S No LR2696 Female Not tested 0 ‐0.0002 ‐0.0009 0.0427 ‐0.007 10.1836 81 22.8 S No LR2761 Male Not tested 0 ‐0.0017 0.0002 0.0093 ‐0.003 10.6959 97 23.8 S No LR2379 Female Not tested 0 0.0016 ‐0.0006 0.0077 ‐0.006 5.0986 76 14.5 SC No LR2477 Male Not tested 0 ‐0.0026 0.0015 0.0057 ‐0.005 8.7014 130 15.3 SC No LR2549 Male Not tested 0 ‐0.0019 0.0003 0.0075 ‐0.0064 7.4137 118 15.1 SC No LR2731 Male Not tested 0 ‐0.0021 0.0001 ‐0.0052 ‐0.009 8.5562 76 16.2 SCA No LR883 Female Not tested 0 ‐0.0036 0.0001 0.0139 ‐0.0075 9.5644 99 16.7 C No LR1858 Female Not tested 0 0.0148 ‐0.0028 ‐0.005 ‐0.011 5.9534 108 14.6 C No

Recent onset T1DM RO1973 Female 8.1 4 0.1504 0.4984 0.3321 0.657 12.2 11.8 82 24.1 S RO2130 Male 5.5 2 0.0524 0.0015 2.3055 0.131 15.6 15.4 71 23.2 S RO2312 Female 10.4 4 0.2769 1.3095 0.0917 0.812 14.6 14.6 199 16.9 SC RO1964 Female 9.8 4 0.6068 0.7542 0.6435 0.447 9.8 9.8 116 17.9 SC RO2348 Female 5.5 4 0.1312 0.1777 1.9395 0.701 9.6 9.4 84 14.6 SC RO2366 Male 7.7 1 0.0615 ‐0.0003 0.1669 ‐0.009 7.7 7.5 177 15.5 SC RO2598 Male 7.9 4 0.1275 0.0036 4.9503 0.089 6.7 6.2 103 17.2 SC RO1939 Female 6.8 4 0.1129 0.8125 0.5275 0.92 11.2 11.0 230 18.4 SCA RO2109 Female 7 4 0.1598 1.161 7.0612 0.621 10.3 9.9 267 20.5 SCA RO253 Male 6.4 4 0.1177 1.2554 3.0061 0.7596 10.7 10.4 89 24.3 SCA RO2024 Female Not tested 0 N/A N/A N/A N/A 10.4 10.0 N/A 15.0 SA RO1037 Male 5.4 4 0.0895 0.6347 2.4508 0.1611 10.2 9.8 N/A 19.3 SCA RO1437 Male 6.8 3 0.0455 0.1381 0.4207 0.618 10.4 10.0 195 16.8 SCA RO2944 Female 8.6 4 0.7483 0.3721 0.274 1.195 6.5 6.4 86 15.5 SA RO2953 Female 7.5 3 0.1535 0.7392 0.5347 ‐0.001 9.1 8.9 N/A 16.5 SCA RO2185 Male 7.5 4 1.3191 0.567 3.6172 0.772 7.2 6.8 182 14.6 SCA RO1707 Female 6.5 3 0.0736 0.449 0.0397 0.425 8.0 7.7 328 14.7 SCA RO2676 Female 8.8 4 0.7234 0.0073 0.2875 0.131 8.1 7.8 278 13.8 SCA RO1012 Female 8 2 0.0373 0.3809 1.0658 0.0103 9.3 9.0 156 16.3 SCA RO246 Male 8.8 2 0.05 0.3562 0.0772 N/A 9.9 9.8 82 15.3 SCA RO946 Female 7.8 4 0.8969 1.0161 3.6723 0.6068 10.8 10.7 78 22.4 SCA RO1442 Female 7.2 4 0.3078 0.0165 3.2237 0.131 6.0 5.7 237 18.7 SCA RO201 Male 8.3 4 0.1978 0.5656 0.767 0.5919 6.7 6.4 78 16.3 SCA RO930 Female 7.3 2 0.012 0.9537 2.4592 ‐0.0051 6.7 6.2 92 14.3 SCA RO62 Female 7.4 4 0.1396 0.4377 0.102 0.0924 7.0 6.5 291 19.8 SCA RO189 Female 7 4 0.08 1.0646 0.7346 0.6288 7.2 6.9 161 15.2 SCA RO1057 Female 7.1 2 0.1644 0.0014 0.1225 ‐0.005 8.8 8.4 252 15.9 SCA RO2808 Male 6.4 4 0.1063 0.4445 0.5883 0.847 9.6 9.4 169 22.8 SCA RO2991 Female 5.6 4 0.1246 0.8591 0.1183 0.172 9.6 9.2 166 20.2 SA RO2503 Male 7.3 2 0.029 0.0861 3.1306 0.0034 11.1 10.7 121 17.0 SA RO2903 Male 7.7 2 0.4621 ‐0.003 0.7849 0 11.4 11.2 81 17.3 SCA RO972 Male 6.9 4 1.1544 1.1083 4.6644 0.0885 11.8 11.5 139 18.8 SCA RO2559 Male 6.1 4 0.2532 0.0395 1.3852 0.2487 11.8 11.4 108 18.2 SA RO2751 Male 7.6 2 0.0806 ‐0.0001 0.1855 0.004 11.8 11.6 82 16.2 SA RO2936 Male 6.2 3 0.5871 0.5838For 9.2393 Peer‐ 0.007Review 11.8Only 11.6 100 17.3 SA RO2359 Female 8.6 3 0.0017 0.8849 0.103 0.284 12.0 11.9 77 17.6 SA Page 39 of 65 Diabetes RO1997 Male 7.1 3 0.6085 0.2183 3.529 ‐0.005 13.0 12.8 136 20.9 SA RO3087 Male 8.8 4 0.2383 0.1682 0.3882 0.6379 7.8 7.2 299 15.8 SCA RO3052 Female 7.1 3 0.308 0.041 0.7766 0.0015 9.0 8.4 238 18.5 SA RO3153 Female 9.5 3 0.015 0.543 1.9255 0.5183 8.0 7.4 80 15.1 SCA RO3040 Male 8.3 3 0.0067 0.5235 0.436 0.5023 7.5 6.9 137 19.8 SA RO3045 Male 6.8 2 0.0285 ‐0.0021 1.303 0.7737 11.6 11.0 106 15.8 SCA RO3139 Female 6.8 4 1.3488 0.1839 1.4278 0.3987 12.5 12.0 182 17.8 SA RO159 Female 9.8 3 0.2988 0.0002 1.4891 0.6071 6.1 5.7 63 16.1 SCA RO1579 Female 7.8 3 0.0495 0.5027 5.2452 0.7 7.0 6.8 231 16.0 SC RO1225 Male 8.8 4 0.3836 0.614 1.1782 0.308 11.8 11.3 204 20.6 SA LO2132A6 Male 5.5 4 0.2441 1.1301 0.8804 0.443 21.9 21.7 185 27.2 S RO2238 Male 7.7 3 0.0327 0.5428 5.2753 0.965 5.8 5.4 199 19.5 C RO2034 Male 6.8 4 1.1162 1.0741 1.7151 0.915 6.0 5.8 139 15.7 C RO355 Female 6.8 3 0.0083 0.5944 0.2184 0.3486 4.1 3.5 101 17.9 C RO814 Male 8.3 2 0.1062 0.0047 0.1083 0.0063 5.0 4.3 256 N/A C RO363 Female 7.4 1 0.0083 ‐0.0024 1.4439 ‐0.0016 8.4 7.9 104 14.8 C RO1071 Female 8.7 3 1.1759 1.0282 2.4215 ‐0.003 11.5 11.4 186 19.4 C RO1139 Female 6.9 4 1.7081 1.2789 3.2528 0.286 11.0 10.8 208 16.9 C RO1329 Female 7 2 0.066 0.2404 0.61 ‐0.002 7.2 7.1 78 14.7 C RO1470 Female 5.7 3 0.098 0.4971 2.7758 0.003 10.6 10.4 149 16.6 C RO1475 Male 5.8 3 0.0097 0.5294 0.6564 0.958 11.3 11.1 126 20.5 C RO1486 Male 5.9 2 ‐0.0004 ‐0.0046 7.2202 0.08 6.3 5.8 139 15.3 C RO1541 Female 6.8 2 0.0605 0.1403 0.4607 ‐0.003 10.2 9.8 161 99.9 C RO1559 Female 7.5 3 0.1076 ‐0.0002 4.1962 0.232 9.6 9.1 240 15.4 C RO1586 Female 7.2 3 0.0022 0.505 0.6193 0.164 5.6 5.2 202 20.1 C RO1749 Female 8.8 4 0.6031 0.7622 4.5672 0.499 5.8 5.4 176 14.4 C RO1916 Female 7.5 4 0.9789 0.6402 0.8433 1.165 7.2 7.0 180 16.9 C RO2522 Female 6.9 4 0.7122 0.8799 0.4855 0.7886 7.9 7.6 168 15.4 C

Auto‐antibody‐negative (AA‐) High HLA Risk Siblings (DR3 and/or DR4) HR49 Female Not tested 1 ‐0.0061 ‐0.0012 0.0149 0.0872 8.0 118 16.2 SC Yes HR69 Female Not tested 0 ‐0.0055 ‐0.0001 ‐0.0037 ‐0.0079 6.3 85 15.2 SC No HR130 Male Not tested 1 ‐0.0031 0.0002 0.0049 0.0426 9.4 84 18.4 SC Yes HR215 Female Not tested 0 0.0227 0.0006 0.01 ‐0.0009 9.1 97 17.2 SC No HR229 Male Not tested 0 0.0094 ‐0.0023 0.009 0.0017 9.5 102 18.1 SCA No HR334 Male Not tested 0 0.006 ‐0.0002 ‐0.0052 ‐0.0023 7.8 88 16.0 SC No HR338 Male Not tested 0 0.0029 0.0016 0 ‐0.0056 8.7 83 14.5 SC No HR371 Male Not tested 0 0.0039 ‐0.0081 ‐0.0048 ‐0.006 7.6 94 21.3 SC No HR878 Female Not tested 0 0.0021 ‐0.0006 ‐0.0034 ‐0.0028 8.1 94 16.6 SC No HR1498 Female Not tested 0 0.0268 ‐0.0035 ‐0.0086 ‐0.001 7.3 81 13.6 SC No HR1593 Female Not tested 0 0.0073 ‐0.0011 ‐0.0048 ‐0.001 5.5 80 15.4 SC No HR1771 Female Not tested 0 0.0233 ‐0.0013 0.0268 0.017 8.3 88 18.9 SC Yes HR2537 Female Not tested 0 0.0119 0.0003 0.002 ‐0.0022 6.4 83 14.4 SC Yes HR2251 Female Not tested 0 0.0045 ‐0.001 ‐0.0022 ‐0.01 7.3 110 22.3 SC Yes HR2339 Female Not tested 0 ‐0.0035 ‐0.0025 0.0059 ‐0.005 5.5 77 14.3 SC No HR182 Male Not tested 0 0.0104 0.0019 0.0131 ‐0.0016 9.0 90 15.0 SC No HR1710 Male Not tested 0 0.0061 ‐0.0015 0.0118 ‐0.013 5.5 93 15.5 S No HR6 Female Not tested 0 ‐0.0062 ‐0.0013 ‐0.0051 ‐0.0032 11.1 99 23.3 SC Yes HR22 Male Not tested 0 0.0107 0.0004 ‐0.0011 0.0063 11.0 93 20.9 SCA No HR26 Female Not tested 0 ‐0.0049 0.002 ‐0.0079 ‐0.0054 11.7 83 15.3 SC No HR116 Male Not tested 0 ‐0.0109 0 0.0022 ‐0.0082 10.4 117 18.8 SC No HR271 Female Not tested 0 0.03 ‐0.0006 ‐0.0081 0.0251 11.4 87 18.8 SC No HR1439 Female Not tested 0 ‐0.002 ‐0.0054 0.0017 ‐0.005 10.4 119 25.8 S Yes HR1975 Female Not tested 0 0.0074 ‐0.0006 ‐0.0017 ‐0.004 10.1 82 23.9 SC No HR2051 Male Not tested 0 0.0023 ‐0.0031 ‐0.0016 0.004 10.0 95 16.6 SC No HR2068 Male Not tested 0 ‐0.0033 ‐0.0005 0.0127 ‐0.006 10.5 76 19.0 SC No HR2767 Female Not tested 0 0.0049 ‐0.0007 0.013 ‐0.004 5.4 99 15.7 SC No HR2684 Male Not tested 0 ‐0.0039 ‐0.0015 0 ‐0.008 7.1 103 14.5 SC No HR2490 Female Not tested 0 0.0007 ‐0.0007 ‐0.002 ‐0.007 9.5 89 18.0 SC No HR2654 Female Not tested 0 ‐0.0012 ‐0.0011 0.0031 ‐0.009 8.5 92 26.2 SC No HR7 Female Not tested 0 ‐0.0004 ‐0.0004 ‐0.0101 ‐0.0043 8.1 93 17.1 CA No HR214 Female Not tested 0 0.0068 0.0028 0 ‐0.0023 10.4 87 19.5 C No

Unrelated Healthy Controls HC2074 Male Not tested 0 ‐0.0098 ‐0.0043 0 ‐0.005 23.0 87 23.8 SC HC2302 Female Not tested 1 0.0166 0.0004 0.1812 ‐0.009 21.3 81 19.0 S HC2593 Female Not tested 0 0.0088 ‐0.001 0.0088 0 23.3 82 19.1 S HC2146 Female Not tested 0 N/A N/A N/A N/A 23.9 N/A N/A SC HC223 Female Not tested 0 0.0037 ‐0.0005 0.005 ‐0.0015 13.6 91 19.6 S HC285 Female Not tested 1 ‐0.0117 0.0014 0.0917 ‐0.0115 7.6 86 16.5 S HC233 Male Not tested 0 0.005 ‐0.0002 0.01 ‐0.0032 8.9 98 16.1 S HC294 Male Not tested 0 ‐0.0069 0.001 0 ‐0.0054 11.9 115 16.7 S HC224 Female Not tested 0 0.0057 0.0006 0 ‐0.0075 13.7 93 23.2 S HC217 Male Not tested 0 ‐0.0016 ‐0.0019 0.01 ‐0.007 10.1 82 N/A SC HC226 Female Not tested 0 ‐0.0038 0.0005 0.01 ‐0.0049 11.3 77 26.8 S HC2790 Female Not tested 0 ‐0.002 0.0017 0.0094 ‐0.007 11.6 126 16.2 SC HC385 Male Not tested 0 ‐0.0091 ‐0.0015 0.0167 ‐0.0101 12.3 92 19.6 S HC295 Male Not tested 0 ‐0.0152 ‐0.0004 0.0048 ‐0.0065 12.4 96 19.4 SC HC272 Female Not tested 0 ‐0.0068 0.0032 0.0052 ‐0.0104 6.3 97 19.5 S HC375 Female Not tested 0 N/A N/A N/A N/A 9.4 N/A 21.4 SC HC2614 Male Not tested 0 ‐0.0043 ‐0.001 ‐0.0031 ‐0.009 10.3 102 18.9 S HC2301 Female Not tested 0 0.009 0.0002 ‐0.0083 ‐0.005 10.6 142 19.9 S HC1006 Male Not tested 0 0.0043 ‐0.0004 0 ‐0.0077 12.8 95 26.1 S HC390 Male Not tested 0 ‐0.01 ‐0.0009 0.016 ‐0.0023 12.9 90 14.9 S HC322 Male Not tested 0 ‐0.0093 0.0014 ‐0.0105 ‐0.0024 12.9 102 17.0 SC HC381 Female Not tested 0 0.0001 0.0022 ‐0.0126 ‐0.0098 13.1 110 25.8 S HC379 Female Not tested 0 ‐0.0021 0.0006 ‐0.0126 ‐0.005 13.4 101 22.5 S HC227 Male Not tested 0 0.0044 0.0014 0.011 0 14.1 91 21.0 S HC1777 Female Not tested 0 0.0142 ‐0.0005 0.0213 ‐0.015 14.9 90 19.0 S HC384 Female Not tested 0 ‐0.0024 0.0007 0.0042 ‐0.0062 15.0 86 21.1 S HC394 Female Not tested 0 ‐0.0066 0.0027For 0.0016 Peer‐0.0077 Review 15.2Only 85 31.7 S HC1089 Female Not tested 0 ‐0.0055 ‐0.0001 ‐0.0071 ‐0.006 15.8 78 17.4 SC Diabetes Page 40 of 65 HC1142 Male Not tested 0 0.0008 ‐0.002 ‐0.0056 ‐0.009 16.3 81 22.3 SC HC1265 Female Not tested 0 0.0042 ‐0.0004 ‐0.005 ‐0.008 16.5 98 20.3 SC HC388 Male Not tested 0 0.0003 ‐0.0007 0 ‐0.0057 16.5 89 30.1 SC HC1249 Female Not tested 0 ‐0.01 ‐0.0007 ‐0.0041 ‐0.007 16.6 86 28.7 SC HC2369 Male Not tested 0 0.0025 0.0009 ‐0.0023 ‐0.009 16.7 95 21.8 SC HC308 Male Not tested 0 ‐0.016 0.002 ‐0.0059 ‐0.0074 17.1 88 20.5 S HC305 Male Not tested 0 0.0019 0.0066 0.0006 ‐0.0046 17.1 76 25.5 SC HC304 Female Not tested 0 0.0003 0.003 0.0133 ‐0.001 17.2 78 20.3 SC HC1601 Female Not tested 0 0.0001 0.0008 0.0032 0.003 17.2 94 22.6 SC HC1543 Female Not tested 0 ‐0.0043 0.0003 0.0056 ‐0.008 17.4 N/A 19.6 SC HC307 Male Not tested 0 ‐0.0069 0.003 0.01 ‐0.0065 17.6 83 26.3 SC HC1730 Female Not tested 0 0.0133 ‐0.0003 0.0069 ‐0.009 17.8 76 27.7 SC HC1369 Female Not tested 0 0.0246 ‐0.0009 0.0086 ‐0.011 21.1 85 22.4 SC HC1365 Female Not tested 0 0.0023 ‐0.0101 0.0174 ‐0.009 21.8 92 N/A SC HC382 Female Not tested 0 0.0069 0.0004 0 ‐0.0047 13.0 101 19.3 S HC1678 Female Not tested 0 0 ‐0.003 ‐0.01 ‐0.005 17.8 85 20.5 SC HC1005 Female Not tested 0 0.0103 0.0019 0 ‐0.0053 16.1 86 25.7 C HC1759 Male Not tested 0 0.0101 ‐0.0007 0.0115 ‐0.008 16.8 75 23.2 C HC284 Male Not tested 0 ‐0.0097 0.001 0 ‐0.0082 9.3 86 18.9 C HC1837 Female Not tested 0 0.0026 ‐0.0009 0.0193 ‐0.014 9.8 98 N/A C HC2789 Female Not tested 0 0.0008 ‐0.0002 ‐0.009 ‐0.011 14.4 93 24.6 C HC1600 Female Not tested 0 0.0312 0.0002 ‐0.0029 0.004 17.2 92 24.0 C HC1247 Male Not tested 0 ‐0.0098 ‐0.0005 ‐0.0041 ‐0.006 24.3 90 24.6 C HC2017 Female Not tested 0 0.0025 ‐0.0013 0 0.002 22.8 88 20.7 C HC2368 Male Not tested 0 0.006 ‐0.0005 ‐0.0135 ‐0.007 18.1 95 17.4 C

Longitudinal Progressor sample series RO T1D A1 Male Not tested 0 0.0169 ‐0.0035 ‐0.0017 ‐0.0096 16.4 21.7 99 23.4 S RO T1D A2 Male Not tested 1 0.0659 0.0013 0.0044 0.4023 18.4 21.7 85 N/A S RO T1D A3 Male Not tested 3 0.1576 0.4249 0.0124 0.424 19.2 21.7 90 N/A S RO T1D A4 Male Not tested 3 0.1602 1.0131 0.0052 0.448 20.2 21.7 91 26.2 S RO T1D A5 Male Not tested 3 0.3064 0.8593 0.007 0.467 21.3 21.7 123 28.1 S RO T1D A6 Male 5.5 4 0.2441 1.1301 0.8804 0.443 21.9 21.7 185 27.2 S RO T1D B1 Female Not tested 1 0.059 0.01 0.0175 0.0022 7.5 9.0 94 16.9 S RO T1D B2 Female Not tested 2 0.1518 0.2252 0.038 ‐0.0013 8.7 9.0 98 N/A S RO T1D B3 Female 6.6 3 0.1026 1.0284 0.1886 ‐0.0007 9.2 9.0 142 16.4 S RO T1D B4 Female 6.8 2 0.0326 0.1231 0.5699 ‐0.006 10.1 9.0 191 16.3 S RO T1D E1 Male Not tested 4 0.2374 0.1123 0.181 0.0518 12.9 19.3 124 16.1 S RO T1D E2 Male Not tested 3 0.1358 0.1238 0.0865 0.0045 13.9 19.3 101 N/A S RO T1D E3 Male Not tested 3 0.1126 0.0899 0.1222 ‐0.001 15.0 19.3 106 N/A S RO T1D E4 Male Not tested 3 0.1613 0.0838 0.0939 0.011 15.4 19.3 107 19.5 S RO T1D E5 Male Not tested 3 0.0849 0.0505 0.0817 0.004 15.9 19.3 95 20.0 S RO T1D E6 Male Not tested 3 0.1231 0.0852 0.054 ‐0.006 16.4 19.3 112 N/A S RO T1D E7 Male Not tested 3 0.0709 0.1258 0.0847 ‐0.001 16.9 19.3 139 N/A S RO T1D E8 Male Not tested 1 0.0507 0.0299 0.04 ‐0.004 18.0 19.3 144 21.0 S RO T1D F1 Male Not tested 4 1.7759 0.0407 0.1657 1.242 4.2 6.9 72 N/A S RO T1D F2 Male Not tested 3 0.8103 0.0032 0.0878 0.769 4.6 6.9 94 18.5 S RO T1D F3 Male Not tested 4 0.6668 0.356 0.1233 1.254 5.4 6.9 104 18.1 S RO T1D F4 Male Not tested 4 0.5901 0.9015 0.1394 1.325 5.9 6.9 116 N/A S RO T1D F5 Male Not tested 4 0.0934 0.229 0.1706 1.178 7.0 6.9 118 16.8 S RO T1D F6 Male 6 4 0.1349 0.2102 2.9047 0.522 7.7 6.9 131 19.5 S RO T1D D1 Female Not tested 0 ‐0.002 ‐0.0054 0.0017 ‐0.005 10.4 17.4 119 25.8 S RO T1D D2 Female Not tested 0 0.0312 ‐0.0014 0 ‐0.007 12.4 17.4 90 N/A S RO T1D D3 Female Not tested 0 0.0026 0.0015 0.0111 ‐0.005 13.4 17.4 88 N/A S RO T1D D4 Female Not tested 3 0.8954 0.431 0.0128 0.271 14.4 17.4 105 N/A S RO T1D D5 Female Not tested 3 1.2523 0.6469 0.0028 0.2157 14.9 17.4 90 N/A S RO T1D D6 Female Not tested 3 1.1303 1.0491 ‐0.0088 0.3655 15.5 17.4 110 N/A S RO T1D D7 Female Not tested 3 0.7322 0.9755 0.0081 0.4358 16.0 17.4 116 30.5 S RO T1D D8 Female 7.9 4 0.7192 1.0327 0.0932 0.4991 17.6 17.4 89 N/A S

Longitudinal Auto‐antibody‐positive (AA+) High HLA Risk Sibling sample series AA+ HRS A1 Male Not tested 4 0.6342 0.3731 0.0689 0.7214 14.0 93 18.7 S AA+ HRS A2 Male Not tested 4 0.6337 0.17 0.0857 0.744 15.1 88 N/A S AA+ HRS A3 Male Not tested 4 1.0194 0.5787 0.0575 0.8022 16.0 82 N/A S AA+ HRS A4 Male Not tested 4 0.8829 0.4392 0.1425 0.794 17.1 58 N/A S AA+ HRS A5 Male Not tested 3 0.2034 0.1397 0.0028 0.936 19.5 79 22.5 S AA+ HRS B1 Female Not tested 3 0.0155 0.024 0.1733 0.3372 13.4 66 17.0 S AA+ HRS B2 Female Not tested 2 0.4579 0.5608 0 N/A 14.0 87 N/A S AA+ HRS B3 Female Not tested 3 0.5105 0.3812 0 0.04 14.7 93 N/A S AA+ HRS B4 Female Not tested 2 0.5204 0.2861 0.0113 0.025 15.8 81 N/A S AA+ HRS B5 Female Not tested 3 0.7481 0.2629 0.0087 0.055 16.5 79 18.1 S AA+ HRS B6 Female Not tested 2 0.972 0.1117 0.0054 0.027 17.6 116 N/A S AA+ HRS B7 Female Not tested 2 0.5992 0.1056 ‐0.0022 0.009 18.7 137 18.4 S AA+ HRS B8 Female Not tested 2 0.4692 0.0451 0 0.005 19.7 147 N/A S AA+ HRS C1 Male Not tested 1 0.0544 0.0047 0.1241 ‐0.01 9.2 62 16.1 S AA+ HRS C2 Male Not tested 1 0.1193 ‐0.0063 0.0067 ‐0.0045 9.8 88 N/A S AA+ HRS C3 Male Not tested 1 0.0922 ‐0.0001 0.0134 0.006 11.0 78 N/A S AA+ HRS C4 Male Not tested 2 0.1727 ‐0.0012 ‐0.0018 0.158 11.5 82 16.0 S AA+ HRS C5 Male Not tested 2 0.1212 0 0.0031 0.338 12.0 97 16.3 S AA+ HRS C6 Male Not tested 2 0.0973 0.0008 0.0052 0.372 12.7 82 N/A S AA+ HRS C7 Male Not tested 2 0.0305 0.5402 0.0036 0.472 14.2 81 18.1 S AA+ HRS E1 Female Not tested 0 ‐0.0058 0.0017 0.024 ‐0.007 12.6 99 31.2 S AA+ HRS E2 Female Not tested 2 ‐0.0041 0.0038 0.2394 ‐0.006 13.6 77 N/A S AA+ HRS E3 Female Not tested 1 ‐0.0055 0.0007 0.3763 ‐0.011 14.6 94 N/A S AA+ HRS E4 Female Not tested 1 ‐0.0035 ‐0.0016 0.3121 ‐0.0081 15.7 104 N/A S AA+ HRS E5 Female Not tested 1 ‐0.0053 ‐0.0005 0.4751 ‐0.006 16.6 86 N/A S AA+ HRS F1 Male Not tested 1 0.0034 ‐0.0013 0.1564 ‐0.002 11.3 85 18.9 S AA+ HRS F2 Male Not tested 1 ‐0.0031 ‐0.0078 0.1303 ‐0.003 12.4 78 N/A S AA+ HRS F3 Male Not tested 0 0.0024 ‐0.0009 0.0253 ‐0.0019 13.3 84 N/A S AA+ HRS F4 Male Not tested 0 0.0033 0.0001 0.0259 0.0021 14.3 105 N/A S AA+ HRS G1 Female Not tested 0 0.0045 ‐0.001 For‐0.0022 Peer ‐Review0.01 Only 7.3 110 22.3 S AA+ HRS G2 Female Not tested 0 ‐0.003 ‐0.002 ‐0.0052 ‐0.005 8.3 100 N/A S Page 41 of 65 Diabetes AA+ HRS G3 Female Not tested 0 ‐0.0054 ‐0.0006 ‐0.0041 ‐0.007 9.4 85 N/A S AA+ HRS G4 Female Not tested 1 ‐0.011 ‐0.0038 0.0622 ‐0.0087 10.4 147 N/A S AA+ HRS G5 Female Not tested 0 0.0007 ‐0.0015 0.0211 ‐0.0067 11.3 93 N/A S AA+ HRS G6 Female Not tested 0 ‐0.0066 ‐0.0007 0.0158 ‐0.0072 12.3 80 26.3 S AA+ HRS H1 Female Not tested 2 0.0143 0.0505 0.0166 0.7273 12.0 108 18.2 S AA+ HRS H2 Female Not tested 2 0.0039 0.0091 ‐0.0022 0.3048 13.8 74 N/A S AA+ HRS H3 Female Not tested 1 0.0127 0.0021 0.0004 0.114 15.1 70 N/A S AA+ HRS H4 Female Not tested 0 0.0128 0.0011 0.0236 0.029 16.0 101 23.0 S AA+ HRS H5 Female Not tested 0 0.0108 ‐0.0002 0 0.026 16.9 94 23.8 S AA+ HRS I1 Female Not tested 1 0.012 0.0003 0.1019 ‐0.0065 2.1 93 18.0 S AA+ HRS I2 Female Not tested 1 0.0009 0.0034 0.1403 ‐0.0072 2.6 87 N/A S AA+ HRS I3 Female Not tested 2 0.0859 ‐0.0011 2.045 ‐0.0039 3.2 91 N/A S AA+ HRS I4 Female Not tested 0 ‐0.0041 ‐0.0019 0.0058 ‐0.006 4.4 76 N/A S AA+ HRS I5 Female Not tested 0 ‐0.0084 0.0003 0.007 ‐0.006 5.4 80 N/A S AA+ HRS I6 Female Not tested 0 ‐0.002 ‐0.0004 ‐0.0059 ‐0.009 7.8 85 N/A S AA+ HRS I7 Female Not tested 0 ‐0.0074 ‐0.0028 ‐0.0042 ‐0.0084 9.6 85 N/A S AA+ HRS I8 Female Not tested 0 0.0003 ‐0.0001 0.0078 ‐0.0094 12.1 93 19.5 S AA+ HRS J1 Male Not tested 1 0.02 0.0144 0 0.0091 5.4 76 15.3 S AA+ HRS J2 Male Not tested 1 0.0169 0.0088 ‐0.0019 0.003 6.4 80 N/A S AA+ HRS J3 Male Not tested 1 0.023 0.0081 0.0026 0.012 7.4 106 N/A S AA+ HRS J4 Male Not tested 0 0.0184 0.005 0.0134 0.012 8.4 82 N/A S AA+ HRS J5 Male Not tested 0 0.0016 ‐0.0001 0.0048 ‐0.0036 12.4 83 N/A S AA+ HRS J6 Male Not tested 0 0.0016 ‐0.0001 0.0055 ‐0.0085 14.4 N/A N/A S

Longitudinal Auto‐antibody‐negative (AA‐) High HLA Risk Sibling sample series AA‐ HRS A1 Male Not tested 0 ‐0.0109 0 0.0022 ‐0.0082 10.4 117 18.8 S AA‐ HRS A2 Male Not tested 0 0.0083 ‐0.0001 0.0044 ‐0.002 15.3 87 19.9 S AA‐ HRS A3 Male Not tested 0 ‐0.0014 ‐0.001 0.0022 ‐0.007 16.5 60 N/A S AA‐ HRS A4 Male Not tested 0 ‐0.0043 ‐0.0011 0.0118 ‐0.008 17.6 88 N/A S AA‐ HRS A5 Male Not tested 0 ‐0.0048 0 0.0043 ‐0.0045 18.9 109 N/A S AA‐ HRS B1 Female Not tested 0 0.0028 ‐0.0005 0.0095 0.001 2.2 82 17.2 S AA‐ HRS B2 Female Not tested 0 0.0154 ‐0.0008 0 ‐0.01 3.1 123 N/A S AA‐ HRS B3 Female Not tested 0 0.0071 ‐0.0012 0.0037 ‐0.002 4.1 92 N/A S AA‐ HRS B4 Female Not tested 0 0.0159 ‐0.0023 0.0054 ‐0.0021 6.1 79 13.4 S AA‐ HRS C1 Female Not tested 0 0.0118 ‐0.0017 0.0027 0.012 14.7 99 19.2 S AA‐ HRS C2 Female Not tested 0 0.0085 0.0007 0.0035 0.003 15.7 94 N/A S AA‐ HRS C3 Female Not tested 0 0.0076 ‐0.0012 0.0112 ‐0.002 16.6 66 N/A S AA‐ HRS C4 Female Not tested 0 0.0065 ‐0.0019 ‐0.0077 0.0037 17.7 96 N/A S AA‐ HRS C5 Female Not tested 0 0.0053 ‐0.0014 0.0054 ‐0.0021 18.6 83 N/A S AA‐ HRS D1 Female Not tested 0 0.0141 0.0027 0.0076 ‐0.01 14.8 92 38.3 S AA‐ HRS D2 Female Not tested 0 0.0053 ‐0.0006 0.0091 ‐0.007 16.4 83 N/A S AA‐ HRS D3 Female Not tested 0 0.0029 ‐0.0012 ‐0.0026 ‐0.0073 17.4 77 N/A S AA‐ HRS D4 Female Not tested 0 0.0124 0.0006 0 ‐0.0041 18.4 93 N/A S AA‐ HRS E2 Female Not tested 0 0.0122 0.0043 0.0017 ‐0.003 7.1 73 N/A S AA‐ HRS E3 Female Not tested 0 0.0046 ‐0.0009 0.003 ‐0.004 8.1 86 N/A S AA‐ HRS E4 Female Not tested 0 0.0051 ‐0.0021 ‐0.0037 ‐0.0026 9.1 79 N/A S AA‐ HRS E5 Female Not tested 0 0.0055 ‐0.0001 0 ‐0.0043 10.1 97 N/A S AA‐ HRS F1 Female Not tested 0 0.0268 ‐0.0035 ‐0.0086 ‐0.001 7.3 81 13.6 S AA‐ HRS F2 Female Not tested 0 0.0123 ‐0.0019 0.0035 ‐0.008 9.3 82 N/A S AA‐ HRS F3 Female Not tested 0 0.0154 ‐0.0001 ‐0.0068 0.001 10.3 80 N/A S AA‐ HRS F4 Female Not tested 0 0.0066 ‐0.0024 ‐0.0128 ‐0.0033 11.3 89 N/A S AA‐ HRS F5 Female Not tested 0 0.0298 ‐0.0001 0.016 ‐0.0034 12.3 84 17.9 S AA‐ HRS F6 Female Not tested 0 0.0117 ‐0.0001 0.0036 ‐0.0045 13.3 102 N/A S AA‐ HRS G1 Female Not tested 0 0.0073 ‐0.0011 ‐0.0048 ‐0.001 5.5 80 15.4 S AA‐ HRS G2 Female Not tested 0 0.0212 0.0014 0.0044 ‐0.005 6.7 132 N/A S AA‐ HRS G3 Female Not tested 0 ‐0.0015 ‐0.0005 0.0027 ‐0.003 8.0 99 N/A S AA‐ HRS G4 Female Not tested 0 ‐0.0021 ‐0.0032 0.0053 ‐0.0041 11.1 94 18.4 S AA‐ HRS H1 Male Not tested 0 0 ‐0.001 0.033 ‐0.011 2.9 83 16.6 S AA‐ HRS H2 Male Not tested 0 0.0004 ‐0.001 0.0062 ‐0.008 5.0 80 N/A S AA‐ HRS H3 Male Not tested 0 ‐0.0014 ‐0.0042 0.0113 ‐0.007 6.7 91 N/A S AA‐ HRS H4 Male Not tested 0 0.0011 ‐0.0004 0.0123 ‐0.032 9.2 97 N/A S AA‐ HRS I1 Male Not tested 0 0.0088 0.0012 ‐0.0032 ‐0.0028 2.1 99 14.8 S AA‐ HRS I2 Male Not tested 0 ‐0.0019 ‐0.0011 0.0096 ‐0.005 6.0 83 N/A S AA‐ HRS I3 Male Not tested 0 0.0018 ‐0.0006 ‐0.0104 0.002 7.1 90 15.1 S AA‐ HRS I4 Male Not tested 0 ‐0.0073 ‐0.001 ‐0.0018 0.0081 8.0 78 15.2 S AA‐ HRS I5 Male Not tested 0 ‐0.0021 ‐0.0024 0.0143 0 9.1 89 N/A S AA‐ HRS I6 Male Not tested 0 0.01 ‐0.0013 0.0286 ‐0.0077 11.2 N/A N/A S AA‐ HRS J1 Male Not tested 0 0.0145 ‐0.0003 ‐0.0017 0.001 3.8 94 15.1 S AA‐ HRS J2 Male Not tested 0 0.0107 0.0018 0.0096 ‐0.006 5.8 118 N/A S AA‐ HRS J3 Male Not tested 0 ‐0.0048 0.0011 ‐0.0029 ‐0.006 6.7 85 N/A S AA‐ HRS J4 Male Not tested 0 ‐0.0047 0.0022 0.0036 ‐0.009 8.1 98 N/A S AA‐ HRS J5 Male Not tested 0 0.0008 ‐0.0018 ‐0.0101 ‐0.0022 8.9 89 14.8 S AA‐ HRS J6 Male Not tested 0 ‐0.0017 0 0.0023 ‐0.0094 10.0 86 N/A S AA‐ HRS J7 Male Not tested 0 ‐0.0016 ‐0.0004 0.0032 ‐0.0201 11.4 N/A N/A S AA‐ HRS K1 Male Not tested 0 0.0132 0.0002 ‐0.0017 ‐0.005 2.2 86 17.0 S AA‐ HRS K2 Male Not tested 0 0.0168 0.0003 ‐0.0067 ‐0.009 4.2 126 N/A S AA‐ HRS K3 Male Not tested 0 0.0001 ‐0.0004 0 ‐0.007 5.1 94 N/A S AA‐ HRS K4 Male Not tested 0 ‐0.0042 0.0019 0.0072 ‐0.01 6.5 96 N/A S AA‐ HRS K5 Male Not tested 0 ‐0.0016 ‐0.0031 ‐0.0101 ‐0.0061 7.2 86 15.1 S AA‐ HRS K6 Male Not tested 0 ‐0.0055 ‐0.0032 ‐0.0035 ‐0.0072 8.4 94 N/A S AA‐ HRS K7 Male Not tested 0 ‐0.0034 ‐0.0013 0.0011 ‐0.0286 9.8 N/A N/A S AA‐ HRS L1 Female Not tested 0 0.0042 ‐0.0014 0 ‐0.0023 3.1 70 18.1 S AA‐ HRS L2 Female Not tested 0 0.0002 ‐0.0104 ‐0.0027 ‐0.006 4.1 66 N/A S AA‐ HRS L3 Female Not tested 0 0.0216 0.0005 0.0067 ‐0.001 6.0 75 N/A S AA‐ HRS L4 Female Not tested 0 0.0069 ‐0.0004 0 0.022 7.2 75 N/A S

Longitudinal Auto‐antibody‐negative (AA‐) Low HLA Risk Sibling sample series AA‐ LRS B1 Female Not tested 0 ‐0.0066 ‐0.0028 0 ‐0.0066 5.5 94 17.5 S AA‐ LRS B2 Female Not tested 0 0.0116 ‐0.0017 0.0022 ‐0.01 8.8 72 N/A S AA‐ LRS B3 Female Not tested 0 ‐0.0056 ‐0.0092 0.0106 ‐0.009 10.2 69 N/A S AA‐ LRS B4 Female Not tested 0 ‐0.0024 ‐0.0005For 0.0106 Peer‐0.0035 Review 14.3Only 70 N/A S AA‐ LRS C1 Male Not tested 0 ‐0.0101 ‐0.0004 ‐0.002 0.001 4.5 78 14.6 S Diabetes Page 42 of 65 AA‐ LRS C2 Male Not tested 0 ‐0.0074 ‐0.002 0.008 ‐0.0027 9.9 96 15.8 S AA‐ LRS C3 Male Not tested 0 ‐0.0029 ‐0.0007 ‐0.001 0.0009 10.8 98 N/A S AA‐ LRS C4 Male Not tested 0 ‐0.0028 ‐0.0009 0.0063 ‐0.0059 11.8 99 N/A S AA‐ LRS C5 Male Not tested 0 N/A N/A N/A N/A 12.8 N/A N/A S AA‐ LRS D1 Male Not tested 0 0.0116 ‐0.0019 0.0014 ‐0.002 10.5 83 14.5 S AA‐ LRS D2 Male Not tested 0 ‐0.0014 ‐0.0019 0 ‐0.001 12.5 91 N/A S AA‐ LRS D3 Male Not tested 0 0.0018 ‐0.0002 0.0061 0.02 13.5 87 N/A S AA‐ LRS D4 Male Not tested 0 ‐0.0106 ‐0.0019 ‐0.0059 0.0018 14.5 82 N/A S AA‐ LRS D5 Male Not tested 0 ‐0.0043 ‐ 0.0003 0.0079 ‐0.0019 15.5 89 17.2 S AA‐ LRS D6 Male Not tested 0 0.0017 ‐0.0001 ‐0.0054 0.0032 16.5 93 N/A S AA‐ LRS E1 Female Not tested 0 0.0059 ‐0.0013 ‐0.0112 ‐0.008 6.3 118 17.5 S AA‐ LRS E2 Female Not tested 0 0.0098 0.0001 ‐0.0044 ‐0.014 7.3 92 N/A S AA‐ LRS E3 Female Not tested 0 ‐0.0026 ‐0.0004 ‐0.0126 ‐0.006 8.3 78 N/A S AA‐ LRS E4 Female Not tested 0 ‐0.0137 ‐0.0024 ‐0.0118 ‐0.0099 9.5 85 N/A S AA‐ LRS E5 Female Not tested 0 ‐0.0022 ‐0.001 ‐0.0083 ‐0.0059 10.2 97 N/A S AA‐ LRS E6 Female Not tested 0 ‐0.0024 ‐0.0006 ‐0.0122 ‐0.0008 11.6 101 18.8 S AA‐ LRS E7 Female Not tested 0 ‐0.0004 ‐0.0007 0.0095 0.0066 12.3 99 N/A S AA‐ LRS F1 Female Not tested 0 0.0003 ‐0.0022 ‐0.0078 ‐0.006 7.4 84 16.7 S AA‐ LRS F2 Female Not tested 0 ‐0.0086 ‐0.0017 ‐0.0022 ‐0.004 8.4 74 N/A S AA‐ LRS F3 Female Not tested 0 ‐0.0027 ‐0.0037 0.007 ‐0.0074 9.4 76 N/A S AA‐ LRS F4 Female Not tested 0 ‐0.0003 ‐0.0005 ‐0.0061 ‐0.0086 10.6 87 N/A S AA‐ LRS F5 Female Not tested 0 ‐0.0023 ‐0.0007 0.0096 ‐0.0029 11.7 84 N/A S AA‐ LRS G1 Female Not tested 0 0.02 ‐0.002 0 0.006 2.6 85 15.1 S AA‐ LRS G2 Female Not tested 0 ‐0.0048 ‐0.0012 ‐0.0018 ‐0.0019 7.1 81 14.1 S AA‐ LRS G3 Female Not tested 0 0.002 ‐0.0016 0.0023 0.004 7.9 78 N/A S AA‐ LRS G4 Female Not tested 0 N/A N/A N/A N/A 10.0 N/A N/A S

For Peer Review Only Page 43 of 65 Diabetes

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Supplemental Table 2: 2422 Regulated probe sets from Cross Sectional Studies (a sortable Excel Spreadsheet with expression levels and statistics for each comparison is available upon request) Fig1d/e HRS: ROT1D: ROT1D: ROT1D: HRS: LRS: Fig1a/b 4way LRS uHC HRS LRS uHC uHC Cross Venn 612 762 261 468 635 1339 Sect 1.125 Fig1e Fig1e Fig1e 1= 1= 1= 1= 1= 1= Mean ROT1D: Fold Fig1e LRS ROT1D HRS uHC (Log2R≥ (Log2R≥ (Log2R≥ (Log2R≥ (Log2R≥ (Log2R≥ Mean ROT1D Mean Mean HRSLRS Filter 575 128 156 647 0.263 0.263 0.263 0.263 0.263 0.263 LRS T1D HRS uHC uHC n_total= 138↑=1 36↑=1 84↑=1 532↑=1 && && && && && && Probeset ID Gene Symbol Gene Title n=42 n=47 n=30 n=44 n=1383 1374 437↓=-1 92↓=-1 72↓=-1 115↓=-1 FDR≤0.2) FDR≤0.2) FDR≤0.2) FDR≤0.2) FDR≤0.2) FDR≤0.2) 204470_at CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity,1.21 alpha)0.60 0.29 -0.01 1 1 1 0 0 -1 1 1 0 1 0 1 233011_at ANXA1 Annexin A1 -0.09 0.44 0.22 -0.15 1 1 0 1 0 0 0 1 0 1 0 0 1554997_a_at PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase0.80 and cyclooxygenase)0.83 0.51 0.33 1 1 0 0 0 -1 0 1 0 0 0 1 210367_s_at PTGES prostaglandin E synthase -0.59 -0.76 -0.92 -1.24 1 1 1 0 0 -1 0 1 0 0 0 1 235008_at ANKRD10 ankyrin repeat domain 10 -0.58 -0.10 -0.39 -0.57 1 1 0 1 0 0 0 1 0 1 0 0 204112_s_at HNMT histamine N-methyltransferase -0.12 -0.56 -0.69 -1.01 1 1 1 0 0 -1 0 1 0 0 0 1 207850_at CXCL3 chemokine (C-X-C motif) ligand 3 0.64 0.21 -0.01 -0.25 1 1 1 0 0 -1 1 1 0 1 0 1 236495_at NAMPT nicotinamide phosphoribosyltransferase -0.64 -0.28 -0.60 -0.72 1 1 0 1 0 0 0 1 0 1 0 0 211924_s_at PLAUR plasminogen activator, urokinase receptor -1.40 -1.65 -1.88 -2.07 1 1 1 0 0 -1 1 1 0 0 0 1 233314_at PTEN phosphatase and tensin homolog 0.34 0.68 0.37 0.29 1 1 0 1 0 0 0 1 0 0 0 0 218228_s_at TNKS2 tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase1.23 2 1.28 1.23 0.90 1 1 0 0 0 -1 0 1 0 0 1 1 228478_at ------0.23 0.29 -0.03 -0.10 1 1 0 1 0 0 0 1 1 1 0 0 230511_at CREM cAMP responsive element modulator -0.68 -0.76 -0.95 -1.15 1 1 0 0 0 -1 0 1 0 0 0 1 1569203_at CXCL2 chemokine (C-X-C motif) ligand 2 -0.59 -0.90 -1.01 -1.26 1 1 1 0 0 -1 1 1 0 1 0 1 242427_at WAC WW domain containing adaptor with coiled-coil 0.08 0.51 0.33 0.15 1 1 0 1 0 0 0 1 0 1 0 0 207075_at NLRP3 NLR family, pyrin domain containing 3 0.45 0.23 0.03 -0.12 1 1 1 0 0 0 1 1 0 0 0 1 221345_at FFAR2 free fatty acid receptor 2 0.84 0.51 0.46 0.17 1 1 1 0 0 -1 1 1 0 1 1 1 201340_s_at ENC1 ectodermal-neural cortex 1 (with BTB-like domain) -0.50 -0.36 -0.44 -0.69 1 1 0 0 0 -1 0 1 0 0 0 0 204971_at CSTA cystatin A (stefin A) -0.25 -0.45 -0.59 -0.76 1 1 1 0 0 -1 1 1 0 0 0 1 205495_s_at GNLY granulysin 0.53 0.50 0.55 0.20 1 1 0 0 0 -1 0 1 0 0 1 1 206026_s_at TNFAIP6 tumor necrosis factor, alpha-induced protein 6 -0.08 -0.27 -0.42 -0.58 1 1 1 0 0 0 0 1 0 0 0 1 209774_x_at CXCL2 chemokine (C-X-C motif) ligand 2 0.97 0.74 0.54 0.45 1 1 1 0 0 0 1 1 0 0 0 1 209967_s_at CREM cAMP responsive element modulator -0.40 -0.44 -0.55 -0.74 1 1 0 0 0 -1 0 1 0 0 0 1 1568830_at IRAK3 interleukin-1 receptor-associated kinase 3 -0.61 -0.29 -0.51 -0.59 1 1 0 1 0 0 0 1 0 1 0 0 216016_at NLRP3 NLR family, pyrin domain containing 3 -0.19 -0.17 -0.19 -0.46 1 1 0 0 0 -1 0 1 0 0 1 1 222909_s_at BAG4 BCL2-associated athanogene 4 -0.30 0.17 0.06 -0.12 1 1 -1 0 0 0 1 1 0 1 0 0 224231_at PRO0471 hypothetical LOC28994 -0.20 0.27 0.00 -0.01 1 1 -1 1 0 0 0 1 1 1 0 0 39402_at IL1B interleukin 1, beta 0.52 0.25 0.14 -0.04 1 1 1 0 0 -1 1 1 0 1 0 1 201043_s_at ANP32A acidic (leucine-rich) nuclear phosphoprotein 32 family, member A 0.38 0.50 0.69 0.23 1 1 0 0 1 0 0 1 0 0 1 0 205067_at IL1B interleukin 1, beta 0.44 0.16 0.06 -0.12 1 1 1 0 0 -1 1 1 0 1 0 1 207388_s_at PTGES prostaglandin E synthase -0.28 -0.42 -0.41 -0.70 1 1 0 0 0 -1 0 1 0 0 1 1 218839_at HEY1 hairy/enhancer-of-split related with YRPW motif 1 0.04 -0.09 -0.17 -0.37 1 1 0 0 0 -1 0 1 0 0 0 1 242163_at THRAP3 thyroid hormone receptor associated protein 3 -0.89 -0.38 -0.38 -0.66 1 1 -1 0 0 0 1 1 0 1 1 0 206366_x_at XCL1 chemokine (C motif) ligand 1 0.73 0.59 0.57 0.32 1 1 0 0 0 -1 0 1 0 0 0 1 240626_at ------0.14 0.37 0.20 0.10 1 1 0 1 0 0 0 1 0 0 0 0 37145_at GNLY granulysin 0.55 0.51 0.57 0.24 1 1 0 0 0 -1 0 1 0 0 1 1 1569573_at AVEN apoptosis, caspase activation inhibitor -0.17 -0.23 -0.21 0.03 1 1 0 0 0 1 0 1 0 0 0 0 1570409_x_at ------0.85 -0.85 -0.80 -0.59 1 1 0 0 0 1 0 1 0 0 0 1 1554152_a_at OGDH oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) -0.70 -0.64 -0.59 -0.37 1 1 0 0 0 1 0 1 0 0 0 1 1557077_a_at ------0.19 -0.29 -0.23 -0.01 1 1 0 0 0 1 0 1 0 0 0 0 1557238_s_at Setd5 SET domain containing 5 -0.28 -0.26 -0.26 0.00 1 1 0 0 0 1 0 1 0 0 1 1 1558078_at ------0.27 -0.30 -0.26 -0.04 1 1 0 0 0 1 0 1 0 0 0 0 1558792_x_at AP2A1 Adaptor-related protein complex 2, alpha 1 subunit -0.13 -0.21 -0.16 0.06 1 1 0 0 0 1 0 1 0 0 0 0 1560014_s_at PDXDC1 pyridoxal-dependent decarboxylase domain containing 1 -0.07 -0.15 -0.12 0.12 1 1 0 0 0 1 0 1 0 0 0 0 1560800_at ------0.81 -1.06 -0.79 -0.79 1 1 0 -1 0 0 0 1 0 0 0 0 1561128_at STK10 serine/threonine kinase 10 -0.27 -0.36 -0.31 -0.09 1 1 0 0 0 1 0 1 0 0 0 0 1562481_at ------0.62 -0.56 -0.60 -0.29 1 1 0 0 0 1 0 1 0 0 1 1 1563460_at ------0.01 -0.04 -0.02 0.22 1 1 0 0 0 1 0 1 0 0 0 0 1569189_at TTC9C tetratricopeptide repeat domain 9C -0.14 -0.19 -0.21 0.08 1 1 0 0 0 1 0 1 0 0 1 0 202940_at WNK1 WNK lysine deficient protein kinase 1 -0.12 -0.33 -0.15 -0.06 1 1 0 -1 0 0 0 1 0 0 0 0 205822_s_at HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) 0.13 -0.05 0.18 0.22 1 1 0 -1 0 0 0 1 0 0 0 0 206169_x_at ZC3H7B zinc finger CCCH-type containing 7B 0.06 0.05 0.12 0.32 1 1 0 0 0 1 0 1 0 0 0 0 210985_s_at SP100 SP100 nuclear antigen -0.93 -0.89 -0.86 -0.62 1 1 0 0 0 1 0 1 0 0 0 1 217653_x_at TRPM6 transient receptor potential cation channel, subfamily M, member-0.08 6 -0.14 -0.04 0.13 1 1 0 0 0 1 0 1 0 0 0 0 228549_at TMEM63A transmembrane protein 63A 0.12 0.11 0.18 0.38 1 1 0 0 0 1 0 1 0 0 0 1 232161_x_at PTPN4 protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte)-0.24 -0.23 -0.28 0.04 1 1 0 0 0 1 0 1 0 0 1 1 232346_at LOC388692 hypothetical LOC388692 -0.05 -0.10 -0.08 0.17 1 1 0 0 0 1 0 1 0 0 0 0 232521_at PCSK7 proprotein convertase subtilisin/kexin type 7 -0.05 -0.11 -0.13 0.15 1 1 0 0 0 1 0 1 0 0 1 0 233405_at Fip1l1 FIP1 like 1 (S. cerevisiae) -0.36 -0.25 -0.28 0.02 1 1 0 0 0 1 0 1 0 0 1 1 235274_at ------0.17 -0.16 -0.21 0.11 1 1 0 0 0 1 0 1 0 0 1 1 236778_at Atrx alpha thalassemia/mental retardation syndrome X-linked (RAD54 homolog,-0.42 -0.29 S. cerevisiae)-0.37 -0.03 1 1 0 0 0 1 0 1 0 0 1 1 237878_at Map2k2 /// LOC407835mitogen-activated protein kinase kinase 2 pseudogene; mitogen-activated-0.35 -0.44protein kinase-0.35 kinase-0.17 2 1 1 0 0 0 1 0 1 0 0 0 0 238913_at Cpsf6 cleavage and polyadenylation specific factor 6, 68kDa -0.08 -0.09 -0.09 0.17 1 1 0 0 0 1 0 1 0 0 0 0 239751_at LOC100506860hypothetical LOC100506860 -0.35 -0.61 -0.38 -0.34 1 1 0 -1 0 0 0 1 0 0 0 0 239893_at MCTP2 multiple C2 domains, transmembrane 2 0.05 0.09 0.08 0.36 1 1 0 0 0 1 0 1 0 0 1 1 242740_at ------0.49 -0.44 -0.39 -0.17 1 1 0 0 0 1 0 1 0 0 0 1 242772_x_at ------0.41 -0.33 -0.52 -0.06 1 1 0 0 0 1 0 1 0 0 1 1 242859_at tfcp2 transcription factor CP2 -0.34 -0.41 -0.36 -0.14 1 1 0 0 0 1 0 1 0 0 0 0 243031_at rtn4 reticulon 4 -0.75 -0.71 -0.62 -0.43 1 1 0 0 0 1 0 1 0 0 0 1 243899_at ARL17A ADP-ribosylation factor-like 17A -0.30 -0.37 -0.29 -0.11 1 1 0 0 0 1 0 1 0 0 0 0 1554670_at GGA1 golgi-associated, gamma adaptin ear containing, ARF binding protein-0.84 1 -0.86 -0.86 -0.58 1 1 0 0 0 1 0 1 0 0 1 0 1556621_a_at CHFR checkpoint with forkhead and ring finger domains -0.54 -0.54 -0.43 -0.26 1 1 0 0 0 1 0 1 0 0 0 1 1556931_at CDC42P2 /// Cdc42cell division cycle 42 (GTP binding protein, 25kDa); cell division cycle-0.56 42 pseudogene-0.52 -0.41 2 -0.23 1 1 0 0 0 1 0 1 0 0 0 1 1557828_a_at C5orf28 Chromosome 5 open reading frame 28 -0.03 -0.11 -0.05 0.18 1 1 0 0 0 1 0 1 0 0 0 0 1562316_at PIGU phosphatidylinositol glycan anchor biosynthesis, class U -0.17 -0.36 -0.18 -0.07 1 1 0 -1 0 0 0 1 0 0 0 0 1564093_at NEK1 NIMA (never in mitosis gene a)-related kinase 1 -0.45 -0.50 -0.44 -0.23 1 1 0 0 0 1 0 1 0 0 0 0 1565595_at Slc6a16 solute carrier family 6, member 16 -0.13 -0.10 -0.06 0.18 1 1 0 0 0 1 0 1 0 0 0 1 1568943_at INPP5D inositol polyphosphate-5-phosphatase, 145kDa -0.06 -0.08 0.00 0.19 1 1 0 0 0 1 0 1 0 0 0 0 1569142_at TRIM13 tripartite motif-containing 13 -0.58 -0.68 -0.61 -0.40 1 1 0 0 0 1 0 1 0 0 0 0 1569180_at ------0.05 -0.01 0.03 0.27 1 1 0 0 0 1 0 1 0 0 0 0 214833_at TMEM63A transmembrane protein 63A -0.06 -0.08 -0.06 0.20 1 1 0 0 0 1 0 1 0 0 0 0 215392_at usp3 ubiquitin specific peptidase 3 -0.10 -0.18 -0.19 0.10 1 1 0 0 0 1 0 1 0 0 1 0 221191_at STAG3L1 stromal antigen 3-like 1 -0.05 -0.14 -0.12 0.14 1 1 0 0 0 1 0 1 0 0 0 0 223314_at TSPAN14 tetraspanin 14 0.02 -0.05 -0.02 0.23 1 1 0 0 0 1 0 1 0 0 0 0 236060_at METTL14 methyltransferase like 14 -0.07 -0.14 -0.09 0.14 1 1 0 0 0 1 0 1 0 0 0 0 239660_at RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) 0.16 0.13 0.18 0.42 1 1 0 0 0 1 0 1 0 0 0 0 239771_at CAND1 cullin-associated and neddylation-dissociated 1 0.43 0.43 0.45 0.71 1 1 0 0 0 1 0 1 0 0 1 1 242241_x_at Tmem50a transmembrane protein 50A -0.05 -0.13 -0.06 0.16 1 1 0 0 0 1 0 1 0 0 0 0 243264_s_at C8orf44 /// SGK3chromosome 8 open reading frame 44 /// serum/glucocorticoid regulated-0.32 kinase-0.37 family,-0.34 member-0.09 3 1 1 0 0 0 1 0 1 0 0 0 0 243910_x_at CAND1 cullin-associated and neddylation-dissociated 1 -0.16 -0.26 -0.24 0.02 1 1 0 0 0 1 0 1 0 0 0 0 243996_at NPR2 natriuretic peptide receptor B/guanylate cyclase B (atrionatriuretic-0.11 peptide-0.08 receptor-0.10 B) 0.20 1 1 0 0 0 1 0 1 0 0 1 1 1553265_at SLC23A3 solute carrier family 23 (nucleobase transporters), member 3 -0.34 -0.44 -0.37 -0.16 1 1 0 0 0 1 0 1 0 0 0 0 1559161_at PDCL phosducin-like -0.54 -0.51 -0.68 -0.22 1 1 0 0 0 1 0 1 0 0 1 1 1559362_at SIK3 serine/threonine-protein kinase QSK -0.33 -0.44 -0.43 -0.15 1 1 0 0 0 1 0 1 0 0 1 0 1562031_at JAK2 Janus kinase 2 -0.03 -0.11 -0.11 0.17 1 1 0 0 0 1 0 1 0 0 1 0 1569320_at GPBP1L1 GC-rich promoter binding protein 1-like 1 -0.28 -0.35 -0.32 -0.07 1 1 0 0 0 1 0 1 0 0 0 0 1570022_at C3orf1 chromosome 3 open reading frame 1 -0.43 -0.60 -0.42 -0.31 1 1 0 -1 0 0 0 1 0 0 0 0 209865_at SLC35A3 solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter),-0.20 -0.31 member-0.37 A3 -0.01 1 1 0 0 0 1 0 1 0 0 1 0 214982_at SNRNP200 small nuclear ribonucleoprotein 200kDa (U5) -0.26 -0.29 -0.31 -0.01 1 1 0 0 0 1 0 1 0 0 1 0 215162_at RALGAPA1 Ral GTPase activating protein, alpha subunit 1 (catalytic) 0.08 -0.02 0.05 0.27 1 1 0 0 0 1 0 1 0 0 0 0

For Peer Review Only Diabetes Page 44 of 65

217671_at rfx3 regulatory factor X, 3 (influences HLA class II expression) -0.04 -0.11 -0.11 0.18 1 1 0 0 0 1 0 1 0 0 1 0 232000_at TTC39B Tetratricopeptide repeat domain 39B 0.09 0.12 0.17 0.41 1 1 0 0 0 1 0 1 0 0 0 1 233824_at ------0.93 -1.01 -1.08 -0.72 1 1 0 0 0 1 0 1 0 0 1 0 233931_at zfr zinc finger RNA binding protein -0.66 -0.72 -0.73 -0.43 1 1 0 0 0 1 0 1 0 0 1 0 237412_at BCAS3 breast carcinoma amplified sequence 3 -0.16 -0.24 -0.14 0.04 1 1 0 0 0 1 0 1 0 0 0 0 239042_at TSR1 TSR1, 20S rRNA accumulation, homolog (S. cerevisiae) -0.17 -0.25 -0.19 0.04 1 1 0 0 0 1 0 1 0 0 0 0 239809_at KLF7 Kruppel-like factor 7 (ubiquitous) -0.05 -0.04 -0.07 0.25 1 1 0 0 0 1 0 1 0 0 1 1 242176_at MEF2A Myocyte enhancer factor 2A -0.26 -0.36 -0.26 -0.07 1 1 0 0 0 1 0 1 0 0 0 0 242440_at ------0.31 -0.37 -0.32 -0.08 1 1 0 0 0 1 0 1 0 0 0 0 1552788_a_at HELB helicase (DNA) B -0.23 -0.41 -0.20 -0.10 1 1 0 -1 0 0 0 1 0 0 0 0 1556828_at ------0.19 -0.06 0.15 0.24 1 1 0 -1 0 0 0 1 0 0 0 0 1557197_a_at LGALS3 lectin, galactoside-binding, soluble, 3 -2.21 -2.23 -2.33 -1.93 1 1 0 0 0 1 0 1 0 0 1 1 1558569_at LOC100131541Hypothetical LOC100131541 -0.33 -0.44 -0.39 -0.14 1 1 0 0 0 1 0 1 0 0 0 0 1560386_at xpo1 exportin 1 (CRM1 homolog, yeast) -0.47 -0.44 -0.47 -0.13 1 1 0 0 0 1 0 1 0 0 1 1 1560391_at pigl phosphatidylinositol glycan anchor biosynthesis, class L -0.12 -0.14 -0.27 0.16 1 1 0 0 0 1 0 1 0 0 1 1 1561600_at SSH2 slingshot homolog 2 (Drosophila) -0.05 -0.15 -0.06 0.15 1 1 0 0 0 1 0 1 0 0 0 0 1561660_at MCART6 mitochondrial carrier triple repeat 6 0.29 0.18 0.23 0.48 1 1 0 0 0 1 0 1 0 0 0 0 1569128_at C3orf38 chromosome 3 open reading frame 38 -0.39 -0.44 -0.41 -0.13 1 1 0 0 0 1 0 1 0 0 1 0 1570505_at ABCB4 ATP-binding cassette, sub-family B (MDR/TAP), member 4 -0.09 -0.06 0.00 0.24 1 1 0 0 0 1 0 1 0 0 0 1 215070_x_at RABGAP1 RAB GTPase activating protein 1 -0.39 -0.50 -0.38 -0.20 1 1 0 0 0 1 0 1 0 0 0 0 217701_x_at Atrx alpha thalassemia/mental retardation syndrome X-linked (RAD54 homolog,-0.50 -0.50 S. cerevisiae)-0.54 -0.20 1 1 0 0 0 1 0 1 0 0 1 1 223814_at TRNT1 tRNA nucleotidyl transferase, CCA-adding, 1 -0.19 -0.43 -0.23 -0.13 1 1 0 -1 0 0 0 1 0 0 0 0 231848_x_at ZNF207 zinc finger protein 207 -0.16 -0.28 -0.26 0.02 1 1 0 0 0 1 0 1 0 0 1 0 231886_at LOC100134822similar to hCG1739109 -0.23 -0.34 -0.26 -0.04 1 1 0 0 0 1 0 1 0 0 0 0 232002_at GPI glucose phosphate isomerase -0.04 -0.17 -0.14 0.13 1 1 0 0 0 1 0 1 0 0 1 0 232688_at BMP2K BMP2 inducible kinase -0.23 -0.41 -0.22 -0.12 1 1 0 -1 0 0 0 1 0 0 0 0 233239_at ZNF407 zinc finger protein 407 -0.07 -0.15 -0.07 0.15 1 1 0 0 0 1 0 1 0 0 0 0 233248_at C1orf43 chromosome 1 open reading frame 43 -0.32 -0.41 -0.33 -0.11 1 1 0 0 0 1 0 1 0 0 0 0 239151_at LOC399753 hypothetical LOC399753 -0.08 -0.25 0.00 0.05 1 1 0 -1 0 0 0 1 0 0 0 0 242228_at BICD1 bicaudal D homolog 1 (Drosophila) -0.44 -0.53 -0.42 -0.23 1 1 0 0 0 1 0 1 0 0 0 0 242261_at IREB2 iron-responsive element binding protein 2 -0.23 -0.27 -0.24 0.04 1 1 0 0 0 1 0 1 0 0 1 1 244847_at FAM13B family with sequence similarity 13, member B -0.77 -0.74 -0.66 -0.44 1 1 0 0 0 1 0 1 0 0 0 1 1552627_a_at ARHGAP5 Rho GTPase activating protein 5 -0.65 -0.54 -0.56 -0.23 1 1 0 0 0 1 0 1 0 0 1 1 1557409_at SPG7 spastic paraplegia 7 (pure and complicated autosomal recessive) -0.27 -0.29 -0.25 0.02 1 1 0 0 0 1 0 1 0 0 1 1 1557581_x_at CABIN1 calcineurin binding protein 1 -0.16 -0.19 -0.21 0.12 1 1 0 0 0 1 0 1 0 0 1 1 1558922_at Tia1 TIA1 cytotoxic granule-associated RNA binding protein -0.23 -0.23 -0.19 0.08 1 1 0 0 0 1 0 1 0 0 1 1 1560013_at PDXDC1 pyridoxal-dependent decarboxylase domain containing 1 -0.19 -0.25 -0.22 0.06 1 1 0 0 0 1 0 1 0 0 1 0 1560676_at SIAH3 seven in absentia homolog 3 (Drosophila) 0.53 0.69 0.75 1.00 1 1 0 0 0 1 0 1 0 0 0 1 1560779_a_at ZNF568 Zinc finger protein 568 -0.03 -0.17 -0.11 0.15 1 1 0 0 0 1 0 1 0 0 0 0 1563051_at OSBP oxysterol binding protein -0.07 -0.09 -0.05 0.22 1 1 0 0 0 1 0 1 0 0 1 1 1569706_at MYSM1 Myb-like, SWIRM and MPN domains 1 -0.36 -0.48 -0.34 -0.16 1 1 0 0 0 1 0 1 0 0 0 0 215398_at Cdc73 cell division cycle 73, Paf1/RNA polymerase II complex component,-0.30 homolog-0.36 (S. cerevisiae)-0.37 -0.05 1 1 0 0 0 1 0 1 0 0 1 0 215626_at dock9 dedicator of cytokinesis 9 0.09 0.06 0.15 0.36 1 1 0 0 0 1 0 1 0 0 0 1 215991_s_at KIAA0090 KIAA0090 -0.48 -0.59 -0.46 -0.27 1 1 0 0 0 1 0 1 0 0 0 0 217529_at ORAI2 ORAI calcium release-activated calcium modulator 2 -0.64 -0.66 -0.62 -0.36 1 1 0 0 0 1 0 1 0 0 0 1 221231_s_at C14orf102 chromosome 14 open reading frame 102 -0.23 -0.31 -0.25 -0.01 1 1 0 0 0 1 0 1 0 0 0 0 222412_s_at SSR3 signal sequence receptor, gamma (translocon-associated protein gamma)-0.85 -0.97 -0.85 -0.66 1 1 0 0 0 1 0 1 0 0 0 0 222906_at FLVCR1 feline leukemia virus subgroup C cellular receptor 1 -0.19 -0.27 -0.18 0.04 1 1 0 0 0 1 0 1 0 0 0 0 234643_x_at ACSM1 acyl-CoA synthetase medium-chain family member 1 -0.37 -0.35 -0.35 -0.05 1 1 0 0 0 1 0 1 0 0 1 1 234645_at MAML2 mastermind-like 2 (Drosophila) -0.22 -0.32 -0.35 -0.01 1 1 0 0 0 1 0 1 0 0 1 0 237377_at IGF1R insulin-like growth factor 1 receptor -0.23 -0.26 -0.20 0.04 1 1 0 0 0 1 0 1 0 0 0 1 237877_at POLH polymerase (DNA directed), eta -0.63 -0.70 -0.68 -0.39 1 1 0 0 0 1 0 1 0 0 1 0 239635_at RBM14 RNA binding motif protein 14 -0.31 -0.45 -0.34 -0.14 1 1 0 0 0 1 0 1 0 0 0 0 239936_at DLEU2 deleted in lymphocytic leukemia 2 (non-protein coding) -0.49 -0.74 -0.55 -0.43 1 1 0 -1 0 0 0 1 0 0 0 0 239963_at ------0.27 0.07 0.40 0.38 1 1 0 -1 0 0 0 1 1 0 0 0 1557987_at LOC641298 SMG1 homolog, phosphatidylinositol 3-kinase-related kinase pseudogene-0.61 -0.45 -0.55 -0.13 1 1 0 0 0 1 0 1 0 0 1 1 1559045_at LOC100128288hypothetical LOC100128288 -0.19 -0.33 -0.31 -0.02 1 1 0 0 0 1 0 1 0 0 1 0 1559201_a_at ostf1 osteoclast stimulating factor 1 -0.32 -0.33 -0.22 -0.02 1 1 0 0 0 1 0 1 0 0 0 1 1559437_at ------0.12 -0.22 -0.10 0.09 1 1 0 0 0 1 0 1 0 0 0 0 1559848_at NSUN4 NOP2/Sun domain family, member 4 -0.28 -0.35 -0.29 -0.03 1 1 0 0 0 1 0 1 0 0 1 0 1565889_at tab2 mitogen-activated protein kinase kinase kinase 7 interacting protein-0.17 2 -0.26 -0.25 0.07 1 1 0 0 0 1 0 1 0 0 1 0 1569578_at LOC100128265ankyrin /// ankrd11 repeat domain 11; hypothetical protein LOC100128265 -0.34 -0.24 -0.28 0.08 1 1 0 0 0 1 0 1 0 0 1 1 1569948_at ------0.35 -0.44 -0.38 -0.12 1 1 0 0 0 1 0 1 0 0 1 0 1570338_at ------0.55 -0.85 -0.64 -0.53 1 1 0 -1 0 0 0 1 0 1 0 0 204270_at SKI v-ski sarcoma viral oncogene homolog (avian) -0.87 -0.56 -0.55 -0.24 1 1 -1 0 0 1 0 1 0 1 1 1 215137_at ------0.05 -0.19 -0.07 0.13 1 1 0 0 0 1 0 1 0 0 0 0 232665_x_at SMURF1 SMAD specific E3 ubiquitin protein ligase 1 -0.37 -0.49 -0.50 -0.17 1 1 0 0 0 1 0 1 0 0 1 0 233055_at ------0.17 -0.28 -0.22 0.04 1 1 0 0 0 1 0 1 0 0 0 0 233957_at tab2 mitogen-activated protein kinase kinase kinase 7 interacting protein-0.88 2 -0.68 -0.59 -0.37 1 1 -1 0 0 1 0 1 0 0 0 1 234112_at Cblb Cas-Br-M (murine) ecotropic retroviral transforming sequence b 0.08 -0.21 0.01 0.10 1 1 0 -1 0 0 0 1 0 1 0 0 238342_at ------0.24 -0.33 -0.27 -0.01 1 1 0 0 0 1 0 1 0 0 0 0 239614_x_at GLS glutaminase -0.33 -0.21 -0.31 0.11 1 1 0 0 0 1 0 1 0 0 1 1 241732_at cdkal1 CDK5 regulatory subunit associated protein 1-like 1 -0.15 -0.25 -0.16 0.07 1 1 0 0 0 1 0 1 0 0 0 0 241860_at STK17B serine/threonine kinase 17b -0.58 -0.39 -0.26 -0.07 1 1 -1 0 0 1 0 1 0 0 0 1 241954_at FDFT1 Farnesyl-diphosphate farnesyltransferase 1 -0.11 -0.08 -0.06 0.24 1 1 0 0 0 1 0 1 0 0 1 1 244872_at RBBP4 retinoblastoma binding protein 4 -0.52 -0.53 -0.66 -0.21 1 1 0 0 0 1 0 1 0 0 1 1 1552633_at ZNF101 zinc finger protein 101 0.16 0.08 0.21 0.41 1 1 0 0 0 1 0 1 0 0 0 0 1554057_at LOC645676 hypothetical LOC645676 -0.13 -0.35 -0.14 -0.02 1 1 0 -1 0 0 0 1 0 0 0 0 1557996_at LOC100132832postmeiotic segregation increased 2-like 5-like -0.33 -0.44 -0.43 -0.11 1 1 0 0 0 1 0 1 0 0 1 0 1558220_at MUC20 Mucin 20, cell surface associated -0.33 -0.44 -0.36 -0.11 1 1 0 0 0 1 0 1 0 0 0 0 1558418_at PIAS1 protein inhibitor of activated STAT, 1 -0.35 -0.55 -0.38 -0.22 1 1 0 -1 0 0 0 1 0 0 0 0 1558802_at TM2D1 TM2 domain containing 1 -0.30 -0.41 -0.33 -0.09 1 1 0 0 0 1 0 1 0 0 0 0 1559449_a_at ZNF254 Zinc finger protein 254 -0.33 -0.34 -0.36 -0.01 1 1 0 0 0 1 0 1 0 0 1 1 1561973_at SMARCC2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin,-0.34 -0.39 subfamily-0.35 c, member-0.06 2 1 1 0 0 0 1 0 1 0 0 1 1 1569041_at JMJD1C jumonji domain containing 1C -0.23 -0.37 -0.38 -0.04 1 1 0 0 0 1 0 1 0 0 1 0 207115_x_at MBTD1 mbt domain containing 1 -0.15 -0.23 -0.23 0.10 1 1 0 0 0 1 0 1 0 0 1 0 207786_at CYP2R1 cytochrome P450, family 2, subfamily R, polypeptide 1 0.01 -0.24 -0.03 0.09 1 1 0 -1 0 0 0 1 0 0 0 0 215252_at DNAJC7 DnaJ (Hsp40) homolog, subfamily C, member 7 -0.44 -0.48 -0.39 -0.15 1 1 0 0 0 1 0 1 0 0 0 1 215318_at N4BP2L2-IT N4BP2L2 intronic transcript (non-protein coding) -0.47 -0.48 -0.56 -0.15 1 1 0 0 0 1 0 1 0 0 1 1 216766_at Prkce protein kinase C, epsilon -0.45 -0.58 -0.51 -0.24 1 1 0 0 0 1 0 1 0 0 0 0 219574_at MARCH1 membrane-associated ring finger (C3HC4) 1 0.02 -0.01 0.08 0.31 1 1 0 0 0 1 0 1 0 0 0 1 219980_at C4orf29 chromosome 4 open reading frame 29 -0.15 -0.25 -0.21 0.09 1 1 0 0 0 1 0 1 0 0 1 0 232020_at SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.29 -0.27 -0.37 0.06 1 1 0 0 0 1 0 1 0 0 1 1 232338_at ZNF431 zinc finger protein 431 -0.10 -0.23 -0.25 0.10 1 1 0 0 0 1 0 1 0 0 1 0 240720_at ------0.20 -0.32 -0.18 0.00 1 1 0 0 0 1 0 1 0 0 0 0 1552621_at POLR2J2 polymerase (RNA) II (DNA directed) polypeptide J2 -0.20 -0.41 -0.23 -0.07 1 1 0 -1 0 0 0 1 0 0 0 0 1557293_at LOC440993 hypothetical LOC440993 -0.50 -0.49 -0.57 -0.16 1 1 0 0 0 1 0 1 0 0 1 1 1557360_at LRPPRC leucine-rich PPR-motif containing -0.03 -0.16 -0.06 0.18 1 1 0 0 0 1 0 1 0 0 0 0 1557737_s_at NKTR natural killer-tumor recognition sequence -0.13 -0.24 -0.30 0.10 1 1 0 0 0 1 0 1 0 0 1 0 1558698_at ZNF264 zinc finger protein 264 -0.52 -0.68 -0.52 -0.35 1 1 0 0 0 1 0 1 0 0 0 0 1560172_at INTS10 integrator complex subunit 10 0.00 -0.10 -0.07 0.24 1 1 0 0 0 1 0 1 0 0 1 0 1564438_at ------0.94 -1.07 -0.97 -0.74 1 1 0 0 0 1 0 1 0 0 0 0 1569864_at SERAC1 serine active site containing 1 -0.42 -0.51 -0.45 -0.17 1 1 0 0 0 1 0 1 0 0 1 0 215043_s_at SMA4 /// SMA5glucuronidase, beta pseudogene /// glucuronidase, beta pseudogene-0.12 -0.28 -0.26 0.06 1 1 0 0 0 1 0 1 0 0 1 0 215191_at KDM2A lysine (K)-specific demethylase 2A -0.57 -0.72 -0.76 -0.38 1 1 0 0 0 1 0 1 0 0 1 0 215586_at PPP3CB protein phosphatase 3 (formerly 2B), catalytic subunit, beta isoform-0.44 -0.47 -0.42 -0.13 1 1 0 0 0 1 0 1 0 0 1 1 217704_x_at SUZ12P Suppressor of zeste 12 homolog pseudogene -0.23 -0.34 -0.22 0.00 1 1 0 0 0 1 0 1 0 0 0 0 232896_at ERBB2IP Erbb2 interacting protein -0.26 -0.39 -0.32 -0.05 1 1 0 0 0 1 0 1 0 0 1 0 233515_at KRR1 KRR1, small subunit (SSU) processome component, homolog (yeast)-0.10 -0.19 -0.12 0.15 1 1 0 0 0 1 0 1 0 0 1 0

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238317_x_at RBMS1 RNA binding motif, single stranded interacting protein 1 -0.32 -0.27 -0.10 0.07 1 1 0 0 0 1 0 1 0 0 0 1 241716_at HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.24 -0.37 -0.29 -0.03 1 1 0 0 0 1 0 1 0 0 0 0 242433_at ZBTB11 zinc finger and BTB domain containing 11 -0.11 -0.32 -0.12 0.02 1 1 0 -1 0 0 0 1 0 0 0 0 243229_at ------0.17 -0.16 0.14 0.18 1 1 0 -1 0 0 0 1 1 1 0 0 1559490_at LRCH3 leucine-rich repeats and calponin homology (CH) domain containing-0.22 3 -0.33 -0.25 0.02 1 1 0 0 0 1 0 1 0 0 1 0 1560209_at ------0.25 -0.37 -0.25 -0.02 1 1 0 0 0 1 0 1 0 0 0 0 1560696_x_at QTRTD1 queuine tRNA-ribosyltransferase domain containing 1 -0.42 -0.62 -0.44 -0.27 1 1 0 -1 0 0 0 1 0 0 0 0 1561893_at egln1 egl nine homolog 1 (C. elegans) -0.33 -0.45 -0.42 -0.10 1 1 0 0 0 1 0 1 0 0 1 0 1569392_at TECR trans-2,3-enoyl-CoA reductase -0.13 -0.27 -0.17 0.08 1 1 0 0 0 1 0 1 0 0 0 0 210965_x_at CDK13 cyclin-dependent kinase 13 -0.32 -0.37 -0.32 -0.02 1 1 0 0 0 1 0 1 0 0 1 1 227891_s_at TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated0.01 factor,-0.16 68kDa -0.06 0.19 1 1 0 0 0 1 0 1 0 0 0 0 234459_at PPHLN1 periphilin 1 -0.07 -0.23 -0.10 0.12 1 1 0 0 0 1 0 1 0 0 0 0 236032_at DNM1L dynamin 1-like 0.18 0.00 0.20 0.35 1 1 0 -1 0 0 0 1 0 0 0 0 238079_at TPM3 tropomyosin 3 -0.53 -0.63 -0.58 -0.28 1 1 0 0 0 1 0 1 0 0 1 0 238769_at MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.23 -0.23 -0.08 0.12 1 1 0 0 0 1 0 1 0 0 0 1 238982_at DENR density-regulated protein -0.20 -0.26 -0.16 0.10 1 1 0 0 0 1 0 1 0 0 0 1 241885_at taf15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated-0.20 factor,-0.29 68kDa -0.22 0.06 1 1 0 0 0 1 0 1 0 0 1 0 242527_at C18orf1 chromosome 18 open reading frame 1 -0.26 -0.28 -0.17 0.07 1 1 0 0 0 1 0 1 0 0 0 1 1560443_at SMCHD1 structural maintenance of chromosomes flexible hinge domain containing0.06 1-0.25 -0.08 0.11 1 1 0 -1 0 0 0 1 0 1 0 0 1561092_at klhdc4 kelch domain containing 4 0.05 -0.17 0.08 0.19 1 1 0 -1 0 0 0 1 0 0 0 0 1562270_at ARHGEF7 Rho guanine nucleotide exchange factor (GEF) 7 -0.45 -0.47 -0.45 -0.12 1 1 0 0 0 1 0 1 0 0 1 1 1563724_at SACS spastic ataxia of Charlevoix-Saguenay (sacsin) -0.05 -0.23 0.01 0.13 1 1 0 -1 0 0 0 1 0 0 0 0 1564972_x_at SETDB2 SET domain, bifurcated 2 0.05 -0.12 0.11 0.24 1 1 0 -1 0 0 0 1 0 0 0 0 1568858_at ubfd1 ubiquitin family domain containing 1 -0.28 -0.35 -0.29 0.01 1 1 0 0 0 1 0 1 0 0 1 1 215330_at FLJ43663 hypothetical LOC378805 -0.62 -0.57 -0.55 -0.21 1 1 0 0 0 1 0 1 0 0 1 1 215986_at ------0.62 -0.74 -0.69 -0.38 1 1 0 0 0 1 0 1 0 0 0 0 233724_at ARNT aryl hydrocarbon receptor nuclear translocator -0.47 -0.61 -0.52 -0.25 1 1 0 0 0 1 0 1 0 0 1 0 239008_at NCRNA00182 Non-protein coding RNA 182 -1.18 -0.92 -0.83 -0.56 1 1 -1 0 0 1 0 1 0 0 0 1 243067_at ------0.04 -0.28 -0.01 0.08 1 1 0 -1 0 0 0 1 0 0 0 0 243673_at RBM41 RNA binding motif protein 41 -0.25 -0.39 -0.37 -0.03 1 1 0 0 0 1 0 1 0 0 1 0 1556318_s_at CAND1 cullin-associated and neddylation-dissociated 1 -0.10 -0.24 -0.19 0.13 1 1 0 0 0 1 0 1 0 0 1 0 1557551_at Cyth1 cytohesin 1 -0.52 -0.56 -0.59 -0.19 1 1 0 0 0 1 0 1 0 0 1 1 1560814_a_at C15orf57 chromosome 15 open reading frame 57 -0.50 -0.45 -0.47 -0.08 1 1 0 0 0 1 0 1 0 0 1 1 1566980_at MAPK1IP1L mitogen-activated protein kinase 1 interacting protein 1-like -0.29 -0.52 -0.31 -0.15 1 1 0 -1 0 0 0 1 0 0 0 0 1569527_at STAU1 staufen, RNA binding protein, homolog 1 (Drosophila) -0.37 -0.51 -0.49 -0.14 1 1 0 0 0 1 0 1 0 0 1 0 215555_at C1orf63 chromosome 1 open reading frame 63 -0.18 -0.31 -0.18 0.06 1 1 0 0 0 1 0 1 0 0 0 0 232759_at Invs inversin -0.03 -0.20 -0.19 0.17 1 1 0 0 0 1 0 1 0 0 1 0 235442_at CXorf56 chromosome X open reading frame 56 -0.74 -0.79 -0.60 -0.42 1 1 0 0 0 1 0 1 0 0 0 1 237586_at EPS15 epidermal growth factor receptor pathway substrate 15 -0.50 -0.43 -0.36 -0.06 1 1 0 0 0 1 0 1 0 0 1 1 239651_at ANAPC5 anaphase promoting complex subunit 5 -0.14 -0.03 -0.02 0.33 1 1 0 0 0 1 0 1 0 0 1 1 241723_at IQGAP2 IQ motif containing GTPase activating protein 2 -0.16 -0.31 -0.20 0.05 1 1 0 0 0 1 0 1 0 0 0 0 242879_x_at Akt3 v-akt murine thymoma viral oncogene homolog 3 (protein kinase B,-0.70 gamma)-0.65 -0.66 -0.28 1 1 0 0 0 1 0 1 0 0 1 1 1556849_at Rnf38 ring finger protein 38 -0.14 -0.20 -0.19 0.18 1 1 0 0 0 1 0 1 0 0 1 1 1557289_s_at GTF2IRD2 GTF2I repeat domain containing 2 -0.09 -0.16 -0.06 0.22 1 1 0 0 0 1 0 1 0 0 1 1 1558719_s_at RPAIN RPA interacting protein 0.05 -0.26 -0.03 0.12 1 1 0 -1 0 0 0 1 0 1 0 0 1559039_at DHX36 DEAH (Asp-Glu-Ala-His) box polypeptide 36 -0.08 -0.17 -0.12 0.21 1 1 0 0 0 1 0 1 0 0 1 1 1560349_at COMMD10 COMM domain containing 10 -0.25 -0.48 -0.29 -0.09 1 1 0 -1 0 0 0 1 0 0 0 0 208154_at ------0.24 -0.32 -0.25 0.06 1 1 0 0 0 1 0 1 0 0 1 1 213650_at LOC100509749Golgin subfamily A member 8B-like -0.03 -0.16 0.03 0.22 1 1 0 0 0 1 0 1 0 0 0 0 215866_at EEF1G eukaryotic translation elongation factor 1 gamma -0.36 -0.60 -0.42 -0.21 1 1 0 -1 0 0 0 1 0 0 0 0 216983_s_at ZNF224 zinc finger protein 224 -0.23 -0.45 -0.27 -0.07 1 1 0 -1 0 0 0 1 0 0 0 0 220216_at C8orf44 chromosome 8 open reading frame 44 -0.43 -0.58 -0.53 -0.21 1 1 0 0 0 1 0 1 0 0 1 0 231979_at ------0.32 -0.43 -0.40 -0.05 1 1 0 0 0 1 0 1 0 0 1 1 239937_at ZNF207 Zinc finger protein 207 -0.02 -0.20 -0.12 0.18 1 1 0 0 0 1 0 1 0 0 1 0 241788_x_at actn4 actinin, alpha 4 -0.76 -0.92 -0.76 -0.54 1 1 0 0 0 1 0 1 0 0 0 0 1555379_at FAM159A family with sequence similarity 159, member A -0.26 -0.34 -0.14 0.05 1 1 0 0 0 1 0 1 0 0 0 1 1556462_a_at Klf12 Kruppel-like factor 12 0.06 -0.26 0.18 0.13 1 1 0 -1 0 0 0 1 1 1 0 0 1557145_at STK38 Serine/threonine kinase 38 -0.13 -0.23 -0.14 0.16 1 1 0 0 0 1 0 1 0 0 1 1 1562161_at ------0.17 -0.30 -0.19 0.09 1 1 0 0 0 1 0 1 0 0 1 0 1564639_at LOC389906 Similar to Serine/threonine-protein kinase PRKX (Protein kinase PKX1)-0.18 -0.28 -0.18 0.11 1 1 0 0 0 1 0 1 0 0 1 1 1564640_at MGA MAX gene associated -0.28 -0.46 -0.36 -0.08 1 1 0 0 0 1 0 1 0 0 1 0 1565810_at Ppp3r1 protein phosphatase 3 (formerly 2B), regulatory subunit B, alpha isoform-0.58 -0.63 -0.51 -0.24 1 1 0 0 0 1 0 1 0 0 1 1 207474_at SNRK SNF related kinase -0.09 -0.24 -0.16 0.14 1 1 0 0 0 1 0 1 0 0 1 0 210867_at CNOT4 CCR4-NOT transcription complex, subunit 4 -0.36 -0.52 -0.44 -0.12 1 1 0 0 0 1 0 1 0 0 1 0 215123_at NPIPL3 nuclear pore complex interacting protein-like 3 -0.46 -0.59 -0.49 -0.19 1 1 0 0 0 1 0 1 0 0 0 0 216850_at SNRPN small nuclear ribonucleoprotein polypeptide N -0.07 -0.30 -0.02 0.09 1 1 0 -1 0 0 0 1 0 0 0 0 220586_at CHD9 chromodomain helicase DNA binding protein 9 -0.26 -0.38 -0.36 0.01 1 1 0 0 0 1 0 1 0 0 1 1 231829_at MAVS mitochondrial antiviral signaling protein -0.33 -0.50 -0.36 -0.11 1 1 0 0 0 1 0 1 0 0 0 0 236887_at KIN KIN, antigenic determinant of recA protein homolog (mouse) -0.54 -0.67 -0.63 -0.27 1 1 0 0 0 1 0 1 0 0 1 1 242549_at PRKD3 protein kinase D3 -0.38 -0.42 -0.30 -0.03 1 1 0 0 0 1 0 1 0 0 1 1 243360_at Tmed4 transmembrane emp24 protein transport domain containing 4 -0.48 -0.58 -0.48 -0.19 1 1 0 0 0 1 0 1 0 0 1 1 1554948_at ------0.83 -0.95 -0.95 -0.55 1 1 0 0 0 1 0 1 0 0 1 0 1558515_at NCRNA00182 non-protein coding RNA 182 -0.79 -0.78 -0.86 -0.38 1 1 0 0 0 1 0 1 0 0 1 1 1562238_at USPL1 ubiquitin specific peptidase like 1 -0.04 -0.28 -0.04 0.12 1 1 0 -1 0 0 0 1 0 0 0 0 1564753_at LASS6 LAG1 homolog, ceramide synthase 6 0.34 0.14 0.32 0.54 1 1 0 -1 0 1 0 1 0 0 0 0 1566040_at LOC100288656Similar to hCG2003116 0.00 -0.14 -0.04 0.27 1 1 0 0 0 1 0 1 0 0 1 1 215308_at XRCC6 X-ray repair complementing defective repair in Chinese hamster cells-0.48 6 -0.73 -0.45 -0.33 1 1 0 -1 0 0 0 1 0 0 0 0 216813_at ------0.80 -0.90 -0.85 -0.50 1 1 0 0 0 1 0 1 0 0 0 0 219341_at CLN8 ceroid-lipofuscinosis, neuronal 8 (epilepsy, progressive with mental-1.32 retardation)-1.55 -1.36 -1.16 1 1 0 -1 0 0 0 1 0 0 0 0 223036_at FARSB phenylalanyl-tRNA synthetase, beta subunit -0.13 -0.30 -0.23 0.10 1 1 0 0 0 1 0 1 0 0 1 0 232330_at C7orf44 chromosome 7 open reading frame 44 -0.07 -0.07 -0.05 0.33 1 1 0 0 0 1 0 1 0 0 1 1 232879_at CRTC3 CREB regulated transcription coactivator 3 -0.16 -0.32 -0.24 0.08 1 1 0 0 0 1 0 1 0 0 1 0 235028_at ------0.43 -0.65 -0.67 -0.25 1 1 0 0 0 1 0 1 0 0 1 0 238393_at bmpr2 bone morphogenetic protein receptor, type II (serine/threonine kinase)-1.12 -1.26 -1.16 -0.85 1 1 0 0 0 1 0 1 0 0 1 1 243796_at Hexim2 hexamthylene bis-acetamide inducible 2 -0.33 -0.54 -0.24 -0.15 1 1 0 -1 0 0 0 1 0 0 0 0 243876_at Fnbp1 formin binding protein 1 -0.22 -0.29 -0.18 0.11 1 1 0 0 0 1 0 1 0 0 1 1 244418_at RTN3 reticulon 3 -0.89 -0.98 -0.82 -0.59 1 1 0 0 0 1 0 1 0 0 0 1 1557527_at Runx1 runt-related transcription factor 1 -1.56 -1.69 -1.72 -1.28 1 1 0 0 0 1 0 1 0 0 1 1 205010_at GNL3L guanine nucleotide binding protein-like 3 (nucleolar)-like -0.47 -0.69 -0.49 -0.28 1 1 0 -1 0 1 0 1 0 0 0 0 211459_at MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.79 -0.93 -0.93 -0.52 1 1 0 0 0 1 0 1 0 0 1 1 215012_at ZNF451 zinc finger protein 451 0.02 -0.21 -0.09 0.20 1 1 0 0 0 1 0 1 0 0 1 0 215375_x_at LRRFIP1 Leucine rich repeat (in FLII) interacting protein 1 -0.86 -0.94 -0.83 -0.53 1 1 0 0 0 1 0 1 0 0 1 1 215558_at UBR2 ubiquitin protein ligase E3 component n-recognin 2 -0.30 -0.50 -0.44 -0.09 1 1 0 0 0 1 0 1 0 0 1 0 220338_at RALGPS2 Ral GEF with PH domain and SH3 binding motif 2 -0.06 -0.28 -0.14 0.13 1 1 0 0 0 1 0 1 0 0 1 0 238723_at ATXN3 ataxin 3 -0.55 -0.71 -0.68 -0.30 1 1 0 0 0 1 0 1 0 0 1 0 1552787_at HELB helicase (DNA) B -0.44 -0.59 -0.41 -0.17 1 1 0 0 0 1 0 1 0 0 0 1 1553726_s_at C6orf170 chromosome 6 open reading frame 170 -0.25 -0.46 -0.38 -0.03 1 1 0 0 0 1 0 1 0 0 1 0 1559025_at SEPT9 septin 9 -0.15 -0.25 -0.10 0.18 1 1 0 0 0 1 0 1 0 0 1 1 1560112_at WDFY2 WD repeat and FYVE domain containing 2 -0.28 -0.42 -0.35 0.00 1 1 0 0 0 1 0 1 0 0 1 1 1563364_at ------0.15 -0.35 -0.31 0.07 1 1 0 0 0 1 0 1 0 0 1 0 1566966_at DPYD dihydropyrimidine dehydrogenase -0.74 -0.95 -0.82 -0.53 1 1 0 0 0 1 0 1 0 0 1 0 239405_at RAB7A RAB7A, member RAS oncogene family -0.99 -1.06 -1.01 -0.63 1 1 0 0 0 1 0 1 0 0 1 1 242126_at ext1 exostoses (multiple) 1 -0.15 -0.30 -0.08 0.12 1 1 0 0 0 1 0 1 0 0 0 1 242182_x_at ITCH itchy E3 ubiquitin protein ligase homolog (mouse) -0.43 -0.57 -0.52 -0.15 1 1 0 0 0 1 0 1 0 0 1 1 1554478_a_at HEATR3 HEAT repeat containing 3 -0.86 -0.84 -0.76 -0.41 1 1 0 0 0 1 0 1 0 0 1 1 1556658_a_at Mbnl1 muscleblind-like (Drosophila) -0.07 -0.31 -0.23 0.12 1 1 0 0 0 1 0 1 0 0 0 0 1557270_at ------0.24 -0.45 -0.35 -0.02 1 1 0 0 0 1 0 1 0 0 0 0 1560662_s_at WHAMML1 ///WAS WHAMML2 protein homolog associated with actin, golgi membranes and 0.15microtubules-like-0.04 0.19 1 (pseudogene)0.39 /// WAS1 protein1 homolog 0associated-1 with actin,0 golgi membranes1 0and microtubules-like1 0 2 (pseudogene)0 0 0 1561733_at INPP5A inositol polyphosphate-5-phosphatase, 40kDa -0.25 -0.48 -0.28 -0.05 1 1 0 -1 0 1 0 1 0 0 0 0

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1564424_at Esyt2 family with sequence similarity 62 (C2 domain containing), member0.04 B -0.23 -0.02 0.20 1 1 0 -1 0 0 0 1 0 0 0 0 205594_at ZNF652 zinc finger protein 652 -0.59 -0.72 -0.64 -0.29 1 1 0 0 0 1 0 1 0 0 0 0 215390_at c9orf5 chromosome 9 open reading frame 5 -0.25 -0.44 -0.36 -0.01 1 1 0 0 0 1 0 1 0 0 1 0 217534_at FAM49B family with sequence similarity 49, member B -0.49 -0.66 -0.55 -0.23 1 1 0 0 0 1 0 1 0 0 1 1 232466_at CUL4A Cullin 4A -0.11 -0.28 -0.22 0.15 1 1 0 0 0 1 0 1 0 0 1 1 235030_at FAM55C family with sequence similarity 55, member C -0.70 -0.71 -0.58 -0.28 1 1 0 0 0 1 0 1 0 0 1 1 235058_at GPN2 GPN-loop GTPase 2 -0.36 -0.54 -0.37 -0.11 1 1 0 -1 0 1 0 1 0 0 0 0 236944_at ------0.11 -0.38 -0.18 0.05 1 1 0 -1 0 0 0 1 0 0 0 0 242576_x_at N4BP2L2 NEDD4 binding protein 2-like 2 -0.28 -0.49 -0.34 -0.05 1 1 0 0 0 1 0 1 0 0 1 0 242797_x_at zfr zinc finger RNA binding protein -0.39 -0.57 -0.58 -0.14 1 1 0 0 0 1 0 1 0 0 1 0 1557580_at CABIN1 calcineurin binding protein 1 -0.29 -0.30 -0.34 0.13 1 1 0 0 0 1 0 1 0 0 1 1 1562250_at SEMA4D sema domain, immunoglobulin domain (Ig), transmembrane domain-0.21 (TM) and-0.29 short-0.26 cytoplasmic0.15 domain, 1(semaphorin)1 4D 0 0 0 1 0 1 0 0 1 1 1562467_at ppp3ca protein phosphatase 3 (formerly 2B), catalytic subunit, alpha isoform-0.74 -0.95 -0.79 -0.51 1 1 0 0 0 1 0 1 0 0 0 0 216765_at MAP2K5 Mitogen-activated protein kinase kinase 5 -0.35 -0.53 -0.34 -0.09 1 1 0 -1 0 1 0 1 0 0 0 0 232295_at GFM1 G elongation factor, mitochondrial 1 -0.24 -0.38 -0.36 0.06 1 1 0 0 0 1 0 1 0 0 1 1 233554_at UBAC2 UBA domain containing 2 -0.04 -0.29 -0.21 0.15 1 1 0 0 0 1 0 1 0 0 1 0 242423_x_at ------0.30 -0.47 -0.30 -0.03 1 1 0 -1 0 1 0 1 0 0 0 1 1563173_at ------0.16 -0.35 -0.04 0.11 1 1 0 -1 0 0 0 1 0 0 0 1 1564820_at LOC100130819RAB6C, /// RAB6C member /// RAB6A RAS oncogene /// LOC150786 family; RAB6A, member RAS oncogene-0.75 family;-0.83 hypothetical-0.80 LOC100130819;-0.37 1 RAB6C-like1 0 0 0 1 0 1 0 0 1 1 1569538_at ------0.70 -0.76 -0.72 -0.31 1 1 0 0 0 1 0 1 0 0 1 1 207735_at RNF125 ring finger protein 125 -0.03 -0.46 -0.21 -0.01 1 1 0 -1 0 0 0 1 0 1 0 0 212172_at AK2 adenylate kinase 2 -0.17 -0.34 -0.25 0.12 1 1 0 0 0 1 0 1 0 0 1 1 216373_at TAPT1 transmembrane anterior posterior transformation 1 -0.48 -0.49 -0.38 -0.04 1 1 0 0 0 1 0 1 0 0 0 1 222319_at nap1l4 nucleosome assembly protein 1-like 4 -0.15 -0.40 -0.28 0.05 1 1 0 0 0 1 0 1 0 0 0 0 224098_at ABAT 4-aminobutyrate aminotransferase -0.84 -0.91 -0.83 -0.46 1 1 0 0 0 1 0 1 0 0 1 1 234149_at THRAP3 thyroid hormone receptor associated protein 3 -0.62 -0.75 -0.67 -0.30 1 1 0 0 0 1 0 1 0 0 0 1 243023_at ------0.09 -0.23 -0.02 0.22 1 1 0 0 0 1 0 1 0 0 0 1 244010_at MLL3 myeloid/lymphoid or mixed-lineage leukemia 3 -0.41 -0.60 -0.53 -0.15 1 1 0 0 0 1 0 1 0 0 1 0 1555199_at GOSR1 golgi SNAP receptor complex member 1 -0.63 -0.78 -0.74 -0.31 1 1 0 0 0 1 0 1 0 0 1 1 1562307_at RNF24 ring finger protein 24 -0.97 -1.20 -1.13 -0.73 1 1 0 0 0 1 0 1 0 0 1 0 1570571_at CCDC91 Coiled-coil domain containing 91 -0.25 -0.42 -0.30 0.04 1 1 0 0 0 1 0 1 0 0 0 1 214918_at HNRNPM heterogeneous nuclear ribonucleoprotein M -0.54 -0.56 -0.50 -0.11 1 1 0 0 0 1 0 1 0 0 1 1 215474_at NSMCE2 non-SMC element 2, MMS21 homolog (S. cerevisiae) -0.74 -0.92 -0.69 -0.45 1 1 0 -1 0 1 0 1 0 0 0 1 224031_at STK17A serine/threonine kinase 17a -0.27 -0.38 -0.13 0.08 1 1 0 0 0 1 0 1 0 0 0 1 1552867_at zmym2 zinc finger, MYM-type 2 -0.73 -0.88 -0.92 -0.40 1 1 0 0 0 1 0 1 0 0 1 0 1559139_at NOC2L nucleolar complex associated 2 homolog (S. cerevisiae) -0.11 -0.34 -0.19 0.13 1 1 0 0 0 1 0 1 0 0 1 0 1559987_at MSI2 musashi homolog 2 (Drosophila) -0.30 -0.46 -0.28 0.01 1 1 0 0 0 1 0 1 0 0 1 1 1570415_at DDX52 DEAD (Asp-Glu-Ala-Asp) box polypeptide 52 -0.31 -0.54 -0.31 -0.07 1 1 0 -1 0 1 0 1 0 0 0 0 205238_at TRMT2B TRM2 tRNA methyltransferase 2 homolog B (S. cerevisiae) -0.45 -0.70 -0.53 -0.23 1 1 0 0 0 1 0 1 0 0 1 0 208077_at C9orf38 chromosome 9 open reading frame 38 0.51 0.17 0.65 0.64 1 1 0 -1 0 0 0 1 1 1 0 0 239453_at Fnbp1 formin binding protein 1 -0.15 -0.36 -0.13 0.11 1 1 0 -1 0 1 0 1 0 0 0 0 1564970_at SETDB2 SET domain, bifurcated 2 -0.08 -0.25 -0.04 0.23 1 1 0 -1 0 1 0 1 0 0 1 1 1569311_at ------0.21 -0.46 -0.35 0.02 1 1 0 0 0 1 0 1 0 0 1 0 212182_at NUDT4 /// NUDT4P1nudix (nucleoside diphosphate linked moiety X)-type motif 4 /// nudix-0.18 (nucleoside-0.36 diphosphate-0.12 0.12 linked moiety1 X)-type1 motif 4 pseudogene0 -1 1 0 1 0 1 0 0 0 1 215900_at PPPDE1 PPPDE peptidase domain containing 1 -0.42 -0.64 -0.45 -0.16 1 1 0 -1 0 1 0 1 0 0 1 0 232535_at ------0.66 -0.86 -0.63 -0.37 1 1 0 -1 0 1 0 1 0 0 0 0 1557512_at CLIP1 CAP-GLY domain containing linker protein 1 -0.61 -0.92 -0.69 -0.42 1 1 0 -1 0 1 0 1 0 0 0 0 1557562_at GRIPAP1 GRIP1 associated protein 1 -0.54 -0.70 -0.55 -0.20 1 1 0 0 0 1 0 1 0 0 1 1 205727_at TEP1 telomerase-associated protein 1 -0.68 -0.98 -0.72 -0.48 1 1 0 -1 0 1 0 1 0 0 0 0 215889_at SKIL SKI-like oncogene -1.26 -1.20 -0.90 -0.71 1 1 0 0 0 1 0 1 0 0 0 1 235220_at YIPF4 Yip1 domain family, member 4 -0.69 -0.79 -0.69 -0.28 1 1 0 0 0 1 0 1 0 0 1 1 215029_at AKIRIN1 akirin 1 -0.60 -0.90 -0.77 -0.39 1 1 0 0 0 1 0 1 0 0 1 0 1556657_at Mbnl1 muscleblind-like (Drosophila) -0.12 -0.49 -0.31 0.03 1 1 0 -1 0 0 0 1 0 0 0 0 1562412_at GPR89A /// GPR89BG protein-coupled /// GPR89C receptor 89C; G protein-coupled receptor 89B; -0.29G protein-coupled-0.34 -0.18 receptor0.18 89A 1 1 0 0 0 1 0 1 0 0 1 1 236237_at kiaa1370 KIAA1370 0.15 -0.09 0.14 0.42 1 1 0 -1 0 1 0 1 0 0 1 1 236985_at EIF4BP7 /// EIF4Bsimilar to eukaryotic translation initiation factor 4H; eukaryotic translation-0.42 -0.58initiation-0.30 factor 4B-0.06 1 1 0 0 0 1 0 1 0 0 0 1 238785_at ------0.67 -0.83 -0.53 -0.31 1 1 0 0 0 1 0 1 0 0 0 1 1566191_at SUZ12 Suppressor of zeste 12 homolog (Drosophila) -0.45 -0.64 -0.53 -0.11 1 1 0 0 0 1 0 1 0 0 1 1 1570249_x_at GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1-0.75 -0.92 -0.72 -0.38 1 1 0 0 0 1 0 1 0 0 0 1 210556_at NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent-0.23 3 -0.43 -0.28 0.09 1 1 0 0 0 1 0 1 0 0 1 1 233866_at KLHL5 kelch-like 5 (Drosophila) -0.46 -0.57 -0.39 -0.04 1 1 0 0 0 1 0 1 0 0 1 1 235061_at PPM1K protein phosphatase, Mg2+/Mn2+ dependent, 1K -0.11 -0.33 -0.18 0.19 1 1 0 0 0 1 0 1 0 0 1 1 238931_at METT10D methyltransferase 10 domain containing -0.44 -0.73 -0.39 -0.19 1 1 0 -1 0 1 0 1 0 0 0 0 1569540_at nlk nemo-like kinase -0.50 -0.79 -0.66 -0.26 1 1 0 0 0 1 0 1 0 0 1 0 1554306_at ITPKB inositol 1,4,5-trisphosphate 3-kinase B -0.55 -0.66 -0.52 -0.11 1 1 0 0 0 1 0 1 0 0 1 1 1560048_at ------0.46 -0.74 -0.56 -0.19 1 1 0 -1 0 1 0 1 0 0 1 1 215175_at PCNX pecanex homolog (Drosophila) -0.61 -0.84 -0.60 -0.27 1 1 0 -1 0 1 0 1 0 0 0 1 232861_at PDP2 pyruvate dehyrogenase phosphatase catalytic subunit 2 -0.79 -0.71 -0.79 -0.15 1 1 0 0 0 1 0 1 0 0 1 1 235551_at WDR4 WD repeat domain 4 -0.59 -0.73 -0.64 -0.17 1 1 0 0 0 1 0 1 0 0 1 1 1555317_at POLK polymerase (DNA directed) kappa -0.43 -0.74 -0.46 -0.17 1 1 0 -1 0 1 0 1 0 0 0 0 234148_at LRRC8D leucine rich repeat containing 8 family, member D -0.33 -0.46 -0.38 0.11 1 1 0 0 0 1 0 1 0 0 1 1 243134_at ------0.47 -0.65 -0.51 -0.09 1 1 0 0 0 1 0 1 0 0 1 1 220900_at ------0.42 -0.77 -0.38 -0.18 1 1 0 -1 0 1 0 1 0 0 0 0 242974_at CD47 CD47 molecule 0.04 -0.36 -0.06 0.23 1 1 0 -1 0 1 0 1 0 1 0 0 207286_at CEP135 centrosomal protein 135kDa -0.10 -0.41 -0.20 0.19 1 1 0 -1 0 1 0 1 0 0 1 1 1570248_at GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1-0.83 -1.02 -0.87 -0.42 1 1 0 0 0 1 0 1 0 0 1 1 1569312_at ZNF146 zinc finger protein 146 -0.37 -0.70 -0.43 -0.08 1 1 0 -1 0 1 0 1 0 0 0 0 242691_at ------1.19 -1.33 -1.24 -0.71 1 1 0 0 0 1 0 1 0 0 1 1 217594_at ZCCHC11 zinc finger, CCHC domain containing 11 -0.75 -0.84 -0.81 -0.21 1 1 0 0 0 1 0 1 0 0 1 1 241879_at LPP LIM domain containing preferred translocation partner in lipoma -0.82 -1.20 -0.84 -0.57 1 1 0 -1 0 1 0 1 0 0 0 0 1565743_at N4BP2L2 NEDD4 binding protein 2-like 2 -0.52 -0.90 -0.74 -0.26 1 1 0 0 0 1 0 1 0 0 0 0 215659_at GSDMB Gasdermin B -0.22 -0.44 -0.28 0.20 1 1 0 0 0 1 0 1 0 0 1 1 1558710_at ARIH1 ariadne homolog, ubiquitin-conjugating enzyme E2 binding protein,-0.29 1 (Drosophila)-0.57 -0.32 0.08 1 1 0 -1 0 1 0 1 0 0 0 1 216121_at PUM2 pumilio homolog 2 (Drosophila) -0.87 -1.13 -0.64 -0.47 1 1 0 -1 0 0 0 1 0 0 0 1 206088_at LRRC37A3 leucine rich repeat containing 37, member A3 -0.32 -0.63 -0.31 0.04 1 1 0 -1 0 1 0 1 0 0 0 1 210858_x_at ATM ataxia telangiectasia mutated -0.58 -0.79 -0.49 -0.10 1 1 0 -1 0 1 0 1 0 0 0 1 1562283_at MAPK1 mitogen-activated protein kinase 1 -1.20 -1.53 -1.43 -0.83 1 1 0 0 0 1 0 1 0 0 1 1 215648_at NUDCD3 NudC domain containing 3 -0.38 -0.63 -0.44 0.07 1 1 0 -1 0 1 0 1 0 0 1 1 1562028_at CCND3 Cyclin D3 0.07 -0.27 -0.10 0.44 1 1 0 0 0 1 0 1 0 0 1 1 208442_s_at ATM ataxia telangiectasia mutated -0.62 -0.96 -0.54 -0.19 1 1 0 -1 0 1 0 1 0 0 0 1 232365_at SIAH1 seven in absentia homolog 1 (Drosophila) -1.02 -1.36 -1.08 -0.56 1 1 0 -1 0 1 0 1 0 0 1 1 1560776_at Fam18b2 /// fam18bfamily with sequence similarity 18, member B2; family with sequence-0.44 similarity-0.82 18, -0.51member B0.04 1 1 0 -1 0 1 0 1 0 0 1 1 235086_at THBS1 thrombospondin 1 0.28 -0.35 -1.01 -1.32 1 1 1 0 0 -1 1 1 0 0 0 1 201743_at CD14 CD14 molecule -1.83 -2.29 -2.98 -3.04 1 1 1 0 0 0 1 1 0 0 0 1 201109_s_at THBS1 thrombospondin 1 -0.02 -0.64 -0.97 -1.34 1 1 1 0 0 -1 1 1 0 0 0 1 220416_at ATP8B4 ATPase, class I, type 8B, member 4 -1.64 -1.82 -2.46 -2.49 1 1 1 0 0 0 1 1 1 0 0 1 201110_s_at THBS1 thrombospondin 1 -0.03 -0.48 -0.95 -1.13 1 1 1 0 0 -1 1 1 0 0 0 1 203887_s_at THBD thrombomodulin -1.91 -2.39 -2.97 -3.03 1 1 1 0 0 0 1 1 0 0 0 1 201506_at TGFBI transforming growth factor, beta-induced, 68kDa -3.09 -3.47 -3.78 -4.10 1 1 1 0 0 -1 1 1 0 0 0 1 218469_at GREM1 gremlin 1 -3.08 -3.22 -4.15 -3.83 1 1 0 0 -1 0 1 1 1 0 0 1 220088_at C5AR1 complement component 5a receptor 1 -1.54 -1.87 -2.33 -2.46 1 1 1 0 0 0 1 1 0 0 0 1 202877_s_at CD93 CD93 molecule -0.72 -1.07 -1.33 -1.64 1 1 1 0 0 -1 1 1 0 0 0 1 202878_s_at CD93 CD93 molecule -0.87 -1.29 -1.78 -1.87 1 1 1 0 0 0 1 1 0 0 0 1 206569_at IL24 interleukin 24 0.28 -0.06 -0.24 -0.60 1 1 1 0 0 -1 0 1 0 0 0 1 212154_at SDC2 syndecan 2 -2.11 -2.55 -2.93 -3.07 1 1 1 0 0 0 1 1 0 0 0 1 201108_s_at THBS1 thrombospondin 1 0.04 -0.26 -0.38 -0.79 1 1 1 0 0 -1 0 1 0 0 0 1 218559_s_at MAFB v-maf musculoaponeurotic fibrosarcoma oncogene homolog B (avian)-0.92 -1.37 -1.71 -1.89 1 1 1 0 0 -1 1 1 0 0 0 1 211307_s_at FCAR Fc fragment of IgA, receptor for -0.88 -1.16 -1.34 -1.66 1 1 1 0 0 -1 0 1 0 0 0 1 205767_at EREG epiregulin 0.06 0.04 -0.61 -0.44 1 1 0 0 -1 0 1 1 1 0 0 1

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207674_at FCAR Fc fragment of IgA, receptor for -0.87 -1.17 -1.62 -1.64 1 1 1 0 0 0 1 1 0 0 0 1 210146_x_at LILRB2 leukocyte immunoglobulin-like receptor, subfamily B (with TM and-1.45 ITIM domains),-1.68 member-1.93 -2.152 1 1 1 0 0 -1 0 1 0 0 0 1 207852_at CXCL5 chemokine (C-X-C motif) ligand 5 -0.34 -0.79 -0.97 -1.25 1 1 1 0 0 -1 1 1 0 0 0 1 230748_at SLC16A6 solute carrier family 16, member 6 (monocarboxylic acid transporter-1.42 7) -1.65 -2.09 -2.09 1 1 1 0 0 0 1 1 0 0 0 1 204924_at TLR2 toll-like receptor 2 -0.58 -0.88 -1.28 -1.31 1 1 1 0 0 0 1 1 0 0 0 1 202888_s_at ANPEP alanyl (membrane) aminopeptidase -1.46 -1.77 -2.15 -2.20 1 1 1 0 0 0 1 1 0 0 0 1 206710_s_at EPB41L3 erythrocyte membrane protein band 4.1-like 3 -1.32 -1.57 -1.85 -1.99 1 1 1 0 0 0 1 1 0 0 0 1 212681_at EPB41L3 erythrocyte membrane protein band 4.1-like 3 -1.30 -1.52 -1.88 -1.94 1 1 1 0 0 0 1 1 0 0 0 1 213338_at TMEM158 transmembrane protein 158 (gene/pseudogene) -0.44 -0.61 -1.10 -1.03 1 1 1 0 0 0 1 1 0 0 0 1 214183_s_at TKTL1 transketolase-like 1 -2.55 -2.90 -3.09 -3.32 1 1 1 0 0 -1 1 1 0 0 0 1 214974_x_at CXCL5 chemokine (C-X-C motif) ligand 5 -0.18 -0.50 -0.85 -0.92 1 1 1 0 0 0 1 1 0 0 0 1 202856_s_at SLC16A3 solute carrier family 16, member 3 (monocarboxylic acid transporter-1.26 4) -1.04 -1.20 -1.44 1 1 0 0 0 -1 0 1 0 0 0 0 219607_s_at MS4A4A membrane-spanning 4-domains, subfamily A, member 4 -3.52 -3.77 -3.95 -4.17 1 1 1 0 0 -1 0 1 0 0 0 1 223344_s_at MS4A7 membrane-spanning 4-domains, subfamily A, member 7 -1.07 -1.29 -1.43 -1.69 1 1 1 0 0 -1 0 1 0 0 0 1 1559910_at PID1 phosphotyrosine interaction domain containing 1 -1.08 -1.34 -1.72 -1.73 1 1 1 0 0 0 1 1 0 0 0 1 206214_at PLA2G7 phospholipase A2, group VII (platelet-activating factor acetylhydrolase,-2.72 plasma)-3.05 -3.19 -3.43 1 1 1 0 0 -1 1 1 0 0 0 1 226066_at MITF microphthalmia-associated transcription factor -1.65 -1.71 -2.33 -2.10 1 1 0 0 -1 0 1 1 1 0 0 1 219434_at TREM1 triggering receptor expressed on myeloid cells 1 -1.88 -2.07 -2.45 -2.45 1 1 1 0 0 0 1 1 0 0 0 1 239336_at Thbs1 thrombospondin 1 -0.04 -0.02 -0.05 -0.41 1 1 0 0 0 -1 0 1 0 0 1 1 208303_s_at CRLF2 cytokine receptor-like factor 2 -0.64 -0.56 -0.71 -0.92 1 1 0 0 0 -1 0 1 0 0 0 1 222877_at NRP2 neuropilin 2 -1.34 -1.06 -1.43 -1.42 1 1 0 1 0 0 0 1 1 1 0 0 1562194_at Zeb2 zinc finger E-box binding homeobox 2 -0.89 -0.88 -1.01 -1.23 1 1 0 0 0 -1 0 1 0 0 0 1 235751_s_at VMO1 vitelline membrane outer layer 1 homolog (chicken) -1.72 -1.96 -2.09 -2.32 1 1 1 0 0 -1 0 1 0 0 0 1 204122_at TYROBP TYRO protein tyrosine kinase binding protein -1.53 -1.75 -2.06 -2.09 1 1 1 0 0 0 1 1 0 0 0 1 204232_at FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide-1.48 -1.67 -1.82 -2.00 1 1 1 0 0 -1 0 1 0 0 0 1 217997_at PHLDA1 pleckstrin homology-like domain, family A, member 1 -1.60 -1.78 -2.13 -2.11 1 1 1 0 0 0 1 1 0 0 0 1 223343_at MS4A7 membrane-spanning 4-domains, subfamily A, member 7 -1.16 -1.34 -1.53 -1.67 1 1 1 0 0 0 0 1 0 0 0 1 1554899_s_at FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide-1.58 -1.79 -1.93 -2.11 1 1 1 0 0 -1 0 1 0 0 0 1 204015_s_at DUSP4 dual specificity phosphatase 4 -0.91 -1.16 -1.21 -1.48 1 1 1 0 0 -1 0 1 0 0 1 1 234932_s_at CDCP1 CUB domain containing protein 1 -0.04 -0.07 -0.12 -0.39 1 1 0 0 0 -1 0 1 0 0 1 1 202855_s_at SLC16A3 solute carrier family 16, member 3 (monocarboxylic acid transporter-1.35 4) -1.22 -1.34 -1.52 1 1 0 0 0 -1 0 1 0 0 0 0 206881_s_at LILRA3 leukocyte immunoglobulin-like receptor, subfamily A (without TM-0.76 domain),-0.95 member-0.97 3 -1.26 1 1 1 0 0 -1 0 1 0 0 1 1 211816_x_at FCAR Fc fragment of IgA, receptor for -0.48 -0.64 -0.65 -0.96 1 1 0 0 0 -1 0 1 0 0 1 1 224480_s_at AGPAT9 1-acylglycerol-3-phosphate O-acyltransferase 9 -1.65 -1.58 -2.11 -1.89 1 1 0 0 -1 0 1 1 1 0 0 0 200730_s_at PTP4A1 protein tyrosine phosphatase type IVA, member 1 0.02 0.09 -0.01 -0.21 1 1 0 0 0 -1 0 1 0 0 0 0 219558_at ATP13A3 ATPase type 13A3 -1.37 -1.01 -1.23 -1.32 1 1 0 1 0 0 0 1 0 1 0 0 226034_at DUSP4 dual specificity phosphatase 4 -1.02 -1.17 -1.27 -1.47 1 1 0 0 0 -1 0 1 0 0 0 1 1553396_a_at CCDC13 coiled-coil domain containing 13 0.45 0.76 0.58 0.47 1 1 0 1 0 0 0 1 0 1 0 0 1570364_at ZNF709 zinc finger protein 709 0.32 0.57 0.24 0.28 1 1 0 1 0 0 0 1 1 0 0 0 222670_s_at MAFB v-maf musculoaponeurotic fibrosarcoma oncogene homolog B (avian)-0.77 -1.10 -1.25 -1.39 1 1 1 0 0 0 1 1 0 1 0 1 210773_s_at FPR2 formyl peptide receptor 2 -0.81 -1.07 -0.94 -1.35 1 1 0 0 0 -1 0 1 0 0 1 1 205126_at VRK2 vaccinia related kinase 2 -1.07 -1.26 -1.42 -1.53 1 1 1 0 0 0 0 1 0 0 0 1 224829_at CPEB4 cytoplasmic polyadenylation element binding protein 4 -0.87 -0.69 -0.86 -0.96 1 1 0 1 0 0 0 1 0 0 0 0 1560225_at CNR1 Cannabinoid receptor 1 (brain) -0.34 -0.27 -0.25 -0.01 1 1 0 0 0 1 0 1 0 0 0 1 1560762_at LOC285972 hypothetical LOC285972 -0.30 -0.06 -0.18 0.20 1 1 0 0 0 1 0 1 0 0 1 1 1560869_a_at ------1.83 -1.72 -1.75 -1.45 1 1 0 0 0 1 0 1 0 0 1 1 1561654_at LIMK2 LIM domain kinase 2 -0.13 -0.18 -0.15 0.10 1 1 0 0 0 1 0 1 0 0 0 0 1566825_at ------0.41 -0.27 -0.33 0.00 1 1 0 0 0 1 0 1 0 0 1 1 1570507_at SFRS2IP Splicing factor, arginine/serine-rich 2, interacting protein 0.11 -0.06 0.12 0.21 1 1 0 -1 0 0 0 1 0 0 0 0 227168_at MIAT myocardial infarction associated transcript (non-protein coding) 0.41 0.39 0.40 0.67 1 1 0 0 0 1 0 1 0 0 1 0 204866_at PHF16 PHD finger protein 16 -0.39 -0.30 -0.34 -0.01 1 1 0 0 0 1 0 1 0 0 1 1 205174_s_at QPCT glutaminyl-peptide cyclotransferase -1.83 -1.78 -1.85 -1.50 1 1 0 0 0 1 0 1 0 0 1 1 207533_at CCL1 chemokine (C-C motif) ligand 1 0.41 0.66 0.54 0.94 1 1 0 0 0 1 0 1 0 0 1 1 215170_s_at CEP152 centrosomal protein 152kDa -0.16 -0.25 -0.32 0.03 1 1 0 0 0 1 0 1 0 0 1 0 244219_at WTAP Wilms tumor 1 associated protein -0.13 -0.41 -0.18 -0.13 1 1 0 -1 0 0 0 1 0 1 0 0 244546_at CYCS cytochrome c, somatic -0.46 -0.35 -0.42 -0.07 1 1 0 0 0 1 0 1 0 0 1 1 1559762_at ------0.18 -0.17 -0.08 0.12 1 1 0 0 0 1 0 1 0 0 0 1 1566603_s_at RPUSD3 RNA pseudouridylate synthase domain containing 3 -0.33 -0.27 -0.28 0.02 1 1 0 0 0 1 0 1 0 0 1 1 206983_at CCR6 chemokine (C-C motif) receptor 6 -0.34 -0.36 -0.28 -0.08 1 1 0 0 0 1 0 1 0 0 0 0 226694_at AKAP2 /// PALM2-AKAP2A kinase (PRKA) anchor protein 2 /// PALM2-AKAP2 readthrough -0.80 -0.58 -0.58 -0.29 1 1 -1 0 0 1 0 1 0 0 1 1 207819_s_at ABCB4 ATP-binding cassette, sub-family B (MDR/TAP), member 4 -0.11 -0.16 -0.07 0.14 1 1 0 0 0 1 0 1 0 0 0 0 228304_at RBM43 RNA binding motif protein 43 0.12 -0.08 0.12 0.22 1 1 0 -1 0 0 0 1 0 0 0 0 1556423_at VASH1 Vasohibin 1 -0.87 -0.82 -0.82 -0.52 1 1 0 0 0 1 0 1 0 0 1 1 1569263_at ------0.02 0.03 0.14 0.34 1 1 0 0 0 1 0 1 0 0 0 1 215118_s_at IGHA1 Immunoglobulin heavy constant alpha 1 -0.24 -0.25 -0.14 0.07 1 1 0 0 0 1 0 1 0 0 0 1 202760_s_at AKAP2 /// PALM2-AKAP2A kinase (PRKA) anchor protein 2 /// PALM2-AKAP2 readthrough -0.75 -0.57 -0.42 -0.24 1 1 -1 0 0 1 1 1 0 0 0 1 231956_at RNF213 ring finger protein 213 -0.06 -0.19 -0.06 0.14 1 1 0 0 0 1 0 1 0 0 0 0 233121_at ZHX2 zinc fingers and homeoboxes 2 -0.26 -0.32 -0.24 0.01 1 1 0 0 0 1 0 1 0 0 0 1 228055_at NAPSB napsin B aspartic peptidase pseudogene -0.35 -0.31 -0.20 0.03 1 1 0 0 0 1 0 1 0 0 0 1 220704_at IKZF1 IKAROS family zinc finger 1 (Ikaros) 0.30 0.28 0.32 0.63 1 1 0 0 0 1 0 1 0 0 1 1 228056_s_at NAPSB napsin B aspartic peptidase pseudogene -0.41 -0.36 -0.36 -0.01 1 1 0 0 0 1 0 1 0 0 1 1 232319_at GGPS1 geranylgeranyl diphosphate synthase 1 -0.15 -0.23 -0.15 0.13 1 1 0 0 0 1 0 1 0 0 1 1 1556461_at Klf12 Kruppel-like factor 12 0.11 -0.13 0.16 0.23 1 1 0 -1 0 0 0 1 0 0 0 0 206157_at PTX3 pentraxin 3, long 0.76 1.00 0.91 1.37 1 1 0 0 0 1 0 1 0 0 1 1 242234_at XAF1 XIAP associated factor 1 0.38 -0.08 0.13 0.36 1 1 0 -1 0 0 0 1 0 1 0 0 244780_at SGPP2 sphingosine-1-phosphate phosphatase 2 -0.26 -0.46 -0.22 -0.01 1 1 0 -1 0 1 0 1 0 0 0 0 232584_at TSHZ2 teashirt zinc finger homeobox 2 0.36 0.20 0.32 0.66 1 1 0 0 0 1 0 1 0 0 1 1 213436_at CNR1 cannabinoid receptor 1 (brain) -1.02 -1.03 -0.91 -0.46 1 1 0 0 0 1 0 1 0 0 1 1 210118_s_at IL1A interleukin 1, alpha 1.81 1.38 1.46 1.03 0 1 1 0 0 -1 0 0 0 0 1 1 1558404_at LOC644242 hypothetical LOC644242 -1.59 -1.27 -1.90 -1.60 1 1 0 1 -1 0 0 0 1 0 0 0 204748_at PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase0.87 and cyclooxygenase)0.66 0.50 0.34 0 1 1 0 0 0 0 0 0 0 0 1 1557267_s_at LOC284952 hypothetical protein LOC284952 -0.21 0.28 0.27 0.03 1 1 -1 0 0 0 1 0 0 1 0 0 202876_s_at PBX2 pre-B-cell leukemia homeobox 2 0.48 0.54 0.55 0.28 0 1 0 0 0 -1 0 0 0 0 1 0 208018_s_at HCK hemopoietic cell kinase -1.25 -1.43 -1.53 -1.69 0 1 1 0 0 0 0 0 0 0 0 1 205787_x_at ZC3H11A zinc finger CCCH-type containing 11A -0.51 -0.02 0.00 -0.27 1 1 -1 0 0 0 1 0 0 1 0 0 207630_s_at CREM cAMP responsive element modulator -0.42 -0.54 -0.59 -0.79 0 1 0 0 0 -1 0 0 0 0 0 1 216015_s_at NLRP3 NLR family, pyrin domain containing 3 -0.04 -0.15 -0.22 -0.40 0 1 0 0 0 -1 0 0 0 0 0 1 229389_at ATG16L2 ATG16 autophagy related 16-like 2 (S. cerevisiae) -0.02 0.24 0.00 -0.01 1 1 0 1 0 0 0 0 0 1 0 0 205114_s_at CCL3 /// CCL3L1chemokine /// CCL3L3 (C-C motif) ligand 3 /// chemokine (C-C motif) ligand 3-like0.75 1 /// 0.54chemokine0.41 (C-C motif)0.29 ligand 3-like0 3 1 1 0 0 0 1 0 0 0 0 1 208067_x_at UTY ubiquitously transcribed tetratricopeptide repeat gene, Y-linked 0.21 0.20 0.33 -0.04 0 1 0 0 0 -1 0 0 0 0 1 0 213524_s_at G0S2 G0/G1switch 2 0.35 0.20 0.20 -0.04 0 1 0 0 0 -1 0 0 0 0 0 1 214211_at FTH1 ferritin, heavy polypeptide 1 -1.11 -1.29 -1.37 -1.53 0 1 1 0 0 0 1 0 0 0 0 1 216069_at ------0.20 0.43 0.39 0.19 1 1 -1 0 0 0 1 0 0 1 0 1 238899_at KIAA1267 KIAA1267 -0.72 -0.20 -0.45 -0.44 1 1 -1 1 0 0 0 0 0 1 0 1 202833_s_at SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin),-0.81 member-0.94 1 -0.85 -1.17 0 1 0 0 0 -1 0 0 0 0 1 1 217813_s_at SPIN1 spindlin 1 -0.53 -0.11 -0.17 -0.34 1 1 -1 0 0 0 1 0 0 1 0 0 222218_s_at PILRA paired immunoglobin-like type 2 receptor alpha -1.09 -1.24 -1.29 -1.47 0 1 0 0 0 -1 0 0 0 0 0 1 238954_at ------0.69 -0.24 -0.27 -0.47 1 1 -1 0 0 0 1 0 0 1 0 0 1558641_at SPATA24 spermatogenesis associated 24 0.18 0.12 0.14 -0.11 0 1 0 0 0 -1 0 0 0 0 0 1 205476_at CCL20 chemokine (C-C motif) ligand 20 0.89 0.67 0.59 0.45 0 1 1 0 0 0 0 0 0 0 0 1 206025_s_at TNFAIP6 tumor necrosis factor, alpha-induced protein 6 -0.03 -0.31 -0.37 -0.52 0 1 1 0 0 0 0 0 0 0 0 1 209057_x_at CDC5L CDC5 cell division cycle 5-like (S. pombe) 0.65 0.63 0.68 0.42 0 1 0 0 0 -1 0 0 0 0 1 0 210140_at CST7 cystatin F (leukocystatin) 0.61 0.47 0.59 0.24 0 1 0 0 0 -1 0 0 0 0 1 1 214508_x_at CREM cAMP responsive element modulator -0.36 -0.49 -0.49 -0.71 0 1 0 0 0 -1 0 0 0 0 0 1 216248_s_at NR4A2 nuclear receptor subfamily 4, group A, member 2 -0.34 -0.39 -0.43 -0.61 0 1 0 0 0 -1 0 0 0 0 0 1 225954_s_at MIDN midnolin 0.37 0.20 0.37 -0.02 0 1 0 0 0 -1 0 0 0 0 1 1 232204_at EBF1 early B-cell factor 1 0.38 0.31 0.32 0.09 0 1 0 0 0 -1 0 0 0 0 0 1 239959_x_at PDE3B phosphodiesterase 3B, cGMP-inhibited 0.76 0.70 0.79 0.48 0 1 0 0 0 -1 0 0 0 0 1 1 1555167_s_at NAMPT nicotinamide phosphoribosyltransferase -0.12 -0.39 -0.37 -0.60 0 1 1 0 0 -1 0 0 0 0 0 1

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1561754_at FLJ44253 hypothetical gene supported by AK096952; AK126241; BC068588 1.25 0.98 1.44 0.77 0 1 0 0 1 -1 0 0 0 0 1 1 1562836_at DDX6 DEAD (Asp-Glu-Ala-Asp) box polypeptide 6 0.08 0.10 0.30 -0.11 0 1 0 0 1 -1 0 0 0 0 1 0 209921_at SLC7A11 solute carrier family 7, (cationic amino acid transporter, y+ system)-1.63 member-1.59 11 -2.08 -1.80 1 1 0 0 -1 0 1 0 1 0 1 0 211074_at FOLR1 folate receptor 1 (adult) -0.15 0.30 0.21 0.08 1 1 -1 0 0 0 1 0 0 1 0 0 211429_s_at SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin),-0.79 member-0.87 1 -0.83 -1.08 0 1 0 0 0 -1 0 0 0 0 0 1 212249_at PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) -0.62 -0.20 -0.23 -0.41 1 1 -1 0 0 0 1 0 0 1 0 0 215352_at GIMAP5 GTPase, IMAP family member 5 -0.06 0.53 0.40 0.33 1 1 -1 0 0 0 1 0 0 1 0 1 226036_x_at CASP2 caspase 2, apoptosis-related cysteine peptidase 0.50 0.42 0.56 0.21 0 1 0 0 0 -1 0 0 0 0 1 1 243296_at NAMPT Nicotinamide phosphoribosyltransferase 0.01 -0.23 -0.32 -0.45 0 1 1 0 0 0 1 0 0 0 0 1 201631_s_at IER3 immediate early response 3 -0.33 -0.52 -0.71 -0.72 0 1 1 0 0 0 1 0 0 0 0 1 210818_s_at BACH1 BTB and CNC homology 1, basic leucine zipper transcription factor-0.50 1 -0.20 -0.43 -0.40 1 1 0 1 0 0 0 0 0 1 0 0 213005_s_at KANK1 KN motif and ankyrin repeat domains 1 -0.81 -0.78 -1.16 -0.98 1 1 0 0 -1 0 1 0 1 0 0 0 227613_at ZNF331 zinc finger protein 331 -0.21 -0.32 -0.21 -0.51 0 1 0 0 0 -1 0 0 0 0 1 1 229274_at GNAS GNAS complex locus 0.07 0.47 0.46 0.27 1 1 -1 0 0 0 1 0 0 1 0 0 200628_s_at WARS tryptophanyl-tRNA synthetase 0.05 -0.03 0.00 -0.22 0 1 0 0 0 -1 0 0 0 0 0 1 202388_at RGS2 regulator of G-protein signaling 2, 24kDa 0.31 0.11 0.18 -0.08 0 1 0 0 0 -1 0 0 0 0 0 1 204103_at CCL4 chemokine (C-C motif) ligand 4 1.23 0.93 0.97 0.74 1 1 1 0 0 -1 0 0 0 1 0 1 205731_s_at NCOA2 nuclear receptor coactivator 2 0.19 0.29 0.52 0.11 0 1 0 0 1 0 1 0 0 0 1 0 219788_at PILRA paired immunoglobin-like type 2 receptor alpha -1.24 -1.41 -1.38 -1.60 0 1 0 0 0 -1 0 0 0 0 0 1 231697_s_at TMEM49 transmembrane protein 49 -0.47 -0.10 -0.16 -0.29 1 1 -1 0 0 0 1 0 0 1 0 0 235476_at TRIM59 tripartite motif-containing 59 -0.52 0.02 0.00 -0.17 1 1 -1 0 0 0 1 0 0 1 0 1 236876_at H1FNT H1 histone family, member N, testis-specific 0.12 0.10 0.18 -0.08 0 1 0 0 0 -1 0 0 0 0 1 0 241315_at FILIP1L filamin A interacting protein 1-like 0.52 0.50 0.62 0.30 0 1 0 0 0 -1 0 0 0 0 1 0 243648_at ZBED6 zinc finger, BED-type containing 6 -0.45 0.06 -0.08 -0.13 1 1 -1 0 0 0 1 0 0 1 0 1 201668_x_at MARCKS myristoylated alanine-rich protein kinase C substrate 0.40 0.40 0.56 0.22 0 1 0 0 0 -1 0 0 0 0 1 0 204794_at DUSP2 dual specificity phosphatase 2 0.17 0.03 0.04 -0.15 0 1 0 0 0 -1 0 0 0 0 0 1 207219_at ZNF643 zinc finger protein 643 -0.46 -0.17 -0.41 -0.35 1 1 0 1 0 0 0 0 0 1 0 0 214567_s_at XCL1 /// XCL2 chemokine (C motif) ligand 1 /// chemokine (C motif) ligand 2 0.71 0.54 0.59 0.35 0 1 0 0 0 -1 0 0 0 0 0 1 219653_at LSM14B LSM14B, SCD6 homolog B (S. cerevisiae) 0.44 0.34 0.48 0.16 0 1 0 0 0 -1 0 0 0 0 1 1 230180_at DDX17 DEAD (Asp-Glu-Ala-Asp) box polypeptide 17 -0.54 -0.04 0.01 -0.22 1 1 -1 0 0 0 1 0 0 1 0 1 240773_at TRIO triple functional domain (PTPRF interacting) -1.29 -0.91 -1.12 -1.09 1 1 0 1 0 0 0 0 0 1 0 0 206180_x_at ZNF747 zinc finger protein 747 0.37 0.33 0.43 0.15 0 1 0 0 0 -1 0 0 0 0 1 0 212762_s_at TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) -0.59 -0.28 -0.49 -0.46 1 1 0 1 0 0 0 0 0 1 0 0 217678_at SLC7A11 solute carrier family 7, (cationic amino acid transporter, y+ system)-1.78 member-1.71 11 -2.21 -1.89 1 1 0 0 -1 0 1 0 1 0 1 0 223999_at PPIL2 peptidylprolyl isomerase (cyclophilin)-like 2 -0.07 0.33 0.15 0.16 1 1 -1 0 0 0 0 0 0 1 0 0 237332_at MON2 MON2 homolog (S. cerevisiae) -0.64 -0.08 -0.32 -0.25 1 1 -1 1 0 0 0 0 0 1 0 1 201266_at TXNRD1 thioredoxin reductase 1 -1.18 -0.96 -1.36 -1.12 1 1 0 0 -1 0 0 0 1 0 0 0 202912_at ADM adrenomedullin -1.21 -1.24 -1.57 -1.39 1 1 0 0 -1 0 1 0 1 0 0 0 207528_s_at SLC7A11 solute carrier family 7, (cationic amino acid transporter, y+ system)-1.75 member-1.58 11 -2.02 -1.74 1 1 0 0 -1 0 0 0 1 0 1 0 212107_s_at DHX9 DEAH (Asp-Glu-Ala-His) box polypeptide 9 -0.44 -0.05 -0.04 -0.21 1 1 -1 0 0 0 1 0 0 1 0 0 214305_s_at SF3B1 splicing factor 3b, subunit 1, 155kDa -0.22 0.23 0.19 0.07 1 1 -1 0 0 0 1 0 0 1 0 1 216433_s_at PRDM2 PR domain containing 2, with ZNF domain -0.39 -0.04 -0.21 -0.19 1 1 -1 0 0 0 0 0 0 1 0 0 222527_s_at RBM22 RNA binding motif protein 22 -0.29 -0.11 0.11 -0.28 0 1 0 0 1 0 1 0 0 0 1 0 222562_s_at TNKS2 tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase-0.22 2 0.17 0.19 0.01 1 1 -1 0 0 0 1 0 0 1 0 0 224775_at IWS1 IWS1 homolog (S. cerevisiae) -0.12 0.00 0.23 -0.15 0 1 0 0 1 0 1 0 0 0 1 0 235645_at ESCO1 establishment of cohesion 1 homolog 1 (S. cerevisiae) -0.13 0.20 0.40 0.05 1 1 -1 0 1 0 1 0 0 1 1 0 236005_at Klf12 Kruppel-like factor 12 -0.01 0.36 0.41 0.20 1 1 -1 0 0 0 1 0 0 1 0 0 238563_at Abi1 abl-interactor 1 -0.16 0.21 0.02 0.04 1 1 -1 0 0 0 0 0 0 1 0 0 1564002_a_at AKD1 adenylate kinase domain containing 1 -0.17 0.16 0.20 0.01 1 1 -1 0 0 0 1 0 0 1 0 0 216361_s_at MYST3 MYST histone acetyltransferase (monocytic leukemia) 3 -0.53 -0.18 0.06 -0.32 1 1 -1 0 1 0 1 0 0 1 1 0 222576_s_at EIF2C1 eukaryotic translation initiation factor 2C, 1 -0.12 0.06 0.25 -0.09 0 1 0 0 1 0 1 0 0 0 1 0 231897_at PTGR1 prostaglandin reductase 1 -1.76 -1.63 -2.00 -1.78 1 1 0 0 -1 0 0 0 1 0 0 0 201070_x_at SF3B1 splicing factor 3b, subunit 1, 155kDa -0.25 0.16 0.14 0.02 1 1 -1 0 0 0 1 0 0 1 0 1 201868_s_at TBL1X transducin (beta)-like 1X-linked -0.52 -0.10 -0.16 -0.24 1 1 -1 0 0 0 1 0 0 1 0 1 211022_s_at ATRX alpha thalassemia/mental retardation syndrome X-linked -0.43 -0.07 0.04 -0.21 1 1 -1 0 0 0 1 0 0 1 0 0 211899_s_at TRAF4 TNF receptor-associated factor 4 -0.02 0.02 0.22 -0.12 0 1 0 0 1 0 0 0 0 0 1 0 231235_at NKTR natural killer-tumor recognition sequence -0.72 -0.08 -0.27 -0.22 1 1 -1 0 0 0 1 0 0 1 0 1 235568_at C19orf59 chromosome 19 open reading frame 59 -3.07 -2.99 -3.31 -3.14 1 1 0 0 -1 0 0 0 1 0 0 0 236946_at Gpr75 G protein-coupled receptor 75 -0.59 -0.16 -0.31 -0.30 1 1 -1 0 0 0 1 0 0 1 0 1 236962_at ptbp2 polypyrimidine tract binding protein 2 -0.77 -0.02 0.06 -0.16 1 1 -1 0 0 0 1 0 0 1 0 1 239014_at CCAR1 Cell division cycle and apoptosis regulator 1 0.18 0.50 0.39 0.35 1 1 -1 0 0 0 0 0 0 1 0 0 242306_at TMEM165 transmembrane protein 165 -0.45 -0.05 -0.17 -0.19 1 1 -1 0 0 0 1 0 0 1 0 0 1558579_at FLJ37786 hypothetical LOC642691 0.62 0.53 0.93 0.40 1 1 0 0 1 0 0 0 1 0 1 0 204864_s_at IL6ST interleukin 6 signal transducer (gp130, oncostatin M receptor) -0.27 0.08 -0.02 -0.04 1 1 -1 0 0 0 0 0 0 1 0 0 205411_at STK4 serine/threonine kinase 4 -0.78 -0.19 -0.38 -0.33 1 1 -1 0 0 0 1 0 0 1 0 1 230681_at TBRG1 transforming growth factor beta regulator 1 -0.14 0.21 0.17 0.08 1 1 -1 0 0 0 1 0 0 1 0 0 233559_s_at WDFY1 WD repeat and FYVE domain containing 1 -0.57 -0.17 -0.16 -0.29 1 1 -1 0 0 0 1 0 0 1 0 1 241683_at HECTD1 HECT domain containing 1 -0.10 0.15 0.35 0.02 0 1 0 0 1 0 1 0 0 0 1 0 243293_at ------0.56 -0.08 -0.07 -0.21 1 1 -1 0 0 0 1 0 0 1 0 1 209803_s_at PHLDA2 pleckstrin homology-like domain, family A, member 2 -0.56 -0.44 -0.80 -0.56 1 1 0 0 -1 0 0 0 1 0 0 0 217856_at RBM8A RNA binding motif protein 8A 0.01 0.36 0.34 0.24 1 1 -1 0 0 0 1 0 0 1 0 0 236125_at DKFZP586I1420hypothetical protein DKFZp586I1420 -0.53 -0.11 -0.18 -0.23 1 1 -1 0 0 0 1 0 0 1 0 1 238281_at RBMS1 RNA binding motif, single stranded interacting protein 1 -0.35 0.01 -0.04 -0.11 1 1 -1 0 0 0 1 0 0 1 0 0 238940_at KLF12 Kruppel-like factor 12 -0.52 0.01 -0.07 -0.11 1 1 -1 0 0 0 1 0 0 1 0 1 241685_x_at C5orf53 chromosome 5 open reading frame 53 -0.54 -0.07 -0.15 -0.20 1 1 -1 0 0 0 1 0 0 1 0 1 1555733_s_at AP1S3 adaptor-related protein complex 1, sigma 3 subunit 0.30 0.34 0.54 0.23 0 1 0 0 1 0 0 0 0 0 1 0 1560142_at GRIK2 glutamate receptor, ionotropic, kainate 2 0.51 0.57 0.76 0.46 0 1 0 0 1 0 0 0 0 0 1 0 201732_s_at CLCN3 chloride channel 3 -0.58 -0.28 -0.26 -0.39 1 1 -1 0 0 0 1 0 0 1 0 0 202887_s_at DDIT4 DNA-damage-inducible transcript 4 -0.12 -0.33 -0.36 -0.44 0 1 1 0 0 0 0 0 0 0 0 1 207334_s_at TGFBR2 transforming growth factor, beta receptor II (70/80kDa) -0.09 0.28 0.30 0.17 1 1 -1 0 0 0 1 0 0 1 0 0 209675_s_at HNRNPUL1 heterogeneous nuclear ribonucleoprotein U-like 1 0.10 0.12 0.30 0.01 0 1 0 0 1 0 0 0 0 0 1 0 217234_s_at EZR ezrin -0.07 0.23 0.31 0.12 1 1 -1 0 0 0 1 0 0 1 0 0 228250_at FNIP1 folliculin interacting protein 1 -1.10 -0.45 -0.67 -0.57 1 1 -1 0 0 0 1 0 0 1 0 1 244568_at SYNE2 spectrin repeat containing, nuclear envelope 2 0.06 0.53 0.46 0.41 1 1 -1 0 0 0 1 0 0 1 0 1 1553267_a_at CNOT6L CCR4-NOT transcription complex, subunit 6-like -0.42 -0.12 -0.22 -0.22 1 1 -1 0 0 0 0 0 0 1 0 0 1557065_at YLPM1 YLP motif containing 1 -0.05 0.26 0.16 0.16 1 1 -1 0 0 0 0 0 0 1 0 0 205197_s_at ATP7A ATPase, Cu++ transporting, alpha polypeptide -0.46 -0.11 -0.25 -0.21 1 1 -1 0 0 0 0 0 0 1 0 0 212332_at RBL2 retinoblastoma-like 2 (p130) -0.29 0.14 0.16 0.04 1 1 -1 0 0 0 1 0 0 1 0 1 212926_at SMC5 structural maintenance of chromosomes 5 -0.34 -0.07 -0.12 -0.17 1 1 -1 0 0 0 0 0 0 1 0 0 213286_at ZFR zinc finger RNA binding protein -0.73 -0.30 -0.34 -0.40 1 1 -1 0 0 0 1 0 0 1 0 1 215092_s_at NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.48 -0.18 -0.26 -0.28 1 1 -1 0 0 0 0 0 0 1 0 0 215589_at SMURF1 SMAD specific E3 ubiquitin protein ligase 1 -0.75 -0.19 -0.37 -0.29 1 1 -1 0 0 0 1 0 0 1 0 1 217878_s_at CDC27 cell division cycle 27 homolog (S. cerevisiae) -0.08 0.07 0.34 -0.03 0 1 0 0 1 0 1 0 0 0 1 0 222387_s_at VPS35 vacuolar protein sorting 35 homolog (S. cerevisiae) -0.41 -0.10 -0.01 -0.20 1 1 -1 0 0 0 1 0 0 1 0 0 224310_s_at BCL11B B-cell CLL/lymphoma 11B (zinc finger protein) 0.21 0.17 0.39 0.07 0 1 0 0 1 0 0 0 0 0 1 0 224580_at SLC38A1 solute carrier family 38, member 1 -0.31 0.04 0.21 -0.06 1 1 -1 0 1 0 1 0 0 1 1 0 227497_at SOX6 SRY (sex determining region Y)-box 6 0.35 0.37 0.54 0.27 0 1 0 0 1 0 0 0 0 0 1 0 238350_at UBN2 ubinuclein 2 -0.70 -0.22 -0.30 -0.33 1 1 -1 0 0 0 1 0 0 1 0 1 242099_at ------0.05 0.33 0.26 0.23 1 1 -1 0 0 0 0 0 0 1 0 0 243304_at LOC286109 hypothetical protein LOC286109 -0.58 -0.18 -0.19 -0.28 1 1 -1 0 0 0 1 0 0 1 0 1 1552417_a_at NEDD1 neural precursor cell expressed, developmentally down-regulated -0.161 0.18 0.24 0.09 1 1 -1 0 0 0 1 0 0 1 0 0 1559822_s_at MTDH metadherin -0.28 0.03 -0.09 -0.06 1 1 -1 0 0 0 0 0 0 1 0 0 1562442_a_at SSBP1 single-stranded DNA binding protein 1 -0.18 0.16 0.07 0.07 1 1 -1 0 0 0 0 0 0 1 0 0 1569238_a_at ------0.37 -0.07 -0.19 -0.16 1 1 -1 0 0 0 0 0 0 1 0 0 200951_s_at CCND2 cyclin D2 -0.63 -0.23 -0.30 -0.33 1 1 -1 0 0 0 1 0 0 1 0 1 203958_s_at ZBTB40 zinc finger and BTB domain containing 40 -0.43 -0.10 -0.23 -0.19 1 1 -1 0 0 0 0 0 0 1 0 0 206341_at IL2RA interleukin 2 receptor, alpha -0.06 -0.01 0.21 -0.09 0 1 0 0 1 0 1 0 0 0 1 0 208621_s_at EZR ezrin -0.05 0.16 0.38 0.07 0 1 0 0 1 0 1 0 0 0 1 0 219159_s_at SLAMF7 SLAM family member 7 0.16 0.57 0.58 0.48 1 1 -1 0 0 0 1 0 0 1 0 1

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221092_at IKZF3 IKAROS family zinc finger 3 (Aiolos) -0.84 -0.29 -0.24 -0.37 1 1 -1 0 0 0 1 0 0 1 0 1 221496_s_at TOB2 transducer of ERBB2, 2 -0.28 0.06 0.07 -0.03 1 1 -1 0 0 0 1 0 0 1 0 0 227062_at Neat1 non-protein coding RNA 84 -1.00 -0.55 -0.74 -0.63 1 1 -1 0 0 0 0 0 0 1 0 1 228824_s_at PTGR1 prostaglandin reductase 1 -1.83 -1.72 -2.02 -1.81 1 1 0 0 -1 0 0 0 1 0 0 0 235003_at UHMK1 U2AF homology motif (UHM) kinase 1 -0.64 -0.23 -0.06 -0.32 1 1 -1 0 0 0 1 0 0 1 0 1 235567_at RORA RAR-related orphan receptor A -0.47 -0.10 -0.16 -0.19 1 1 -1 0 0 0 1 0 0 1 0 1 236417_at mfn1 mitofusin 1 -0.07 0.21 0.17 0.12 1 1 -1 0 0 0 0 0 0 1 0 0 242924_at PITPNB phosphatidylinositol transfer protein, beta -0.88 -0.36 -0.57 -0.45 1 1 -1 0 0 0 1 0 0 1 0 1 244153_at ZNF207 zinc finger protein 207 -0.36 -0.01 -0.18 -0.10 1 1 -1 0 0 0 0 0 0 1 0 0 244396_at G3BP1 GTPase activating protein (SH3 domain) binding protein 1 -0.19 0.14 0.10 0.05 1 1 -1 0 0 0 1 0 0 1 0 0 1557910_at HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.61 -0.37 -0.07 -0.46 0 1 0 0 1 0 1 0 0 0 1 0 209616_s_at CES1 carboxylesterase 1 -1.50 -1.61 -1.91 -1.69 1 1 0 0 -1 0 1 0 1 0 0 0 229413_s_at Pcgf3 polycomb group ring finger 3 -0.33 -0.03 -0.08 -0.11 1 1 -1 0 0 0 0 0 0 1 0 0 230607_at DENND4A DENN/MADD domain containing 4A -0.05 0.40 0.36 0.33 1 1 -1 0 0 0 1 0 0 1 0 1 232386_at VPS13C vacuolar protein sorting 13 homolog C (S. cerevisiae) -0.24 0.01 0.04 -0.07 0 1 -1 0 0 0 1 0 0 0 0 0 235740_at MCTP1 multiple C2 domains, transmembrane 1 -0.36 -0.30 -0.57 -0.38 1 1 0 0 -1 0 0 0 1 0 0 0 237741_at SLC25A36 Solute carrier family 25, member 36 0.06 0.39 0.45 0.30 1 1 -1 0 0 0 1 0 0 1 0 0 240062_at FAM3C family with sequence similarity 3, member C -0.04 0.25 0.16 0.17 1 1 -1 0 0 0 0 0 0 1 0 0 242975_s_at Gnas GNAS complex locus -0.26 0.14 0.18 0.06 1 1 -1 0 0 0 1 0 0 1 0 1 244737_at KIAA1429 KIAA1429 -0.24 0.07 -0.01 -0.01 1 1 -1 0 0 0 0 0 0 1 0 0 201879_at ARIH1 ariadne homolog, ubiquitin-conjugating enzyme E2 binding protein,-0.53 1 (Drosophila)-0.18 -0.27 -0.25 1 1 -1 0 0 0 1 0 0 1 0 1 211751_at LOC653513 /// hypotheticalPDE4DIP LOC653513 /// phosphodiesterase 4D interacting protein-0.33 -0.32 -0.08 -0.39 0 1 0 0 1 0 0 0 0 0 1 0 212451_at SECISBP2L SECIS binding protein 2-like -0.31 0.01 0.09 -0.06 1 1 -1 0 0 0 1 0 0 1 0 0 214034_at ERAP1 endoplasmic reticulum aminopeptidase 1 0.22 0.31 0.56 0.24 0 1 0 0 1 0 1 0 0 0 1 0 220983_s_at SPRY4 sprouty homolog 4 (Drosophila) -0.55 -0.26 -0.34 -0.33 1 1 -1 0 0 0 0 0 0 1 0 0 223701_s_at USP47 ubiquitin specific peptidase 47 -0.36 -0.11 -0.03 -0.18 0 1 -1 0 0 0 1 0 0 0 0 0 225800_at JAZF1 JAZF zinc finger 1 -0.08 0.21 0.24 0.13 1 1 -1 0 0 0 1 0 0 1 0 0 240941_at ITSN2 Intersectin 2 -0.38 -0.07 -0.06 -0.14 1 1 -1 0 0 0 1 0 0 1 0 0 244733_at usp33 ubiquitin specific peptidase 33 -0.19 0.15 0.08 0.07 1 1 -1 0 0 0 1 0 0 1 0 0 214843_s_at USP33 ubiquitin specific peptidase 33 -0.15 0.20 0.13 0.14 1 1 -1 0 0 0 1 0 0 1 0 1 215434_x_at LOC100288142neuroblastoma /// NBPF1 /// NBPF10 breakpoint family member /// neuroblastoma breakpoint-0.23 family,-0.06 member0.12 1 ///-0.11 neuroblastoma0 breakpoint1 family,0 member0 10 1 0 1 0 0 0 0 0 216595_at FAM186A family with sequence similarity 186, member A 0.52 0.47 0.70 0.41 0 1 0 0 1 0 0 0 0 0 1 0 218166_s_at RSF1 remodeling and spacing factor 1 -0.41 -0.03 -0.21 -0.09 1 1 -1 0 0 0 0 0 0 1 0 1 222313_at CNOT2 CCR4-NOT transcription complex, subunit 2 -0.05 0.25 0.19 0.18 1 1 -1 0 0 0 0 0 0 1 0 0 223465_at COL4A3BP collagen, type IV, alpha 3 (Goodpasture antigen) binding protein -0.82 -0.46 -0.57 -0.51 1 1 -1 0 0 0 0 0 0 1 0 1 224012_at ANKRD20A1 ///ankyrin ANKRD20A2 repeat /// domain ANKRD20A3 20 family, /// memberANKRD20A4 A1 /// ankyrin repeat domain0.78 20 0.55family, member0.95 A20.49 /// ankyrin1 repeat domain1 20 family,0 member0 A3 ///1 ankyrin 0repeat domain0 20 family,0 member1 A4 0 1 1 227740_at UHMK1 U2AF homology motif (UHM) kinase 1 -0.56 -0.18 -0.05 -0.24 1 1 -1 0 0 0 1 0 0 1 0 1 229881_at KLF12 Kruppel-like factor 12 0.02 0.32 0.36 0.26 1 1 -1 0 0 0 1 0 0 1 0 0 234306_s_at SLAMF7 SLAM family member 7 0.13 0.50 0.51 0.44 1 1 -1 0 0 0 1 0 0 1 0 1 235537_at OCIAD1 OCIA domain containing 1 -0.12 0.18 0.33 0.12 1 1 -1 0 0 0 1 0 0 1 0 0 235574_at GBP4 guanylate binding protein 4 -0.12 0.17 0.19 0.11 1 1 -1 0 0 0 1 0 0 1 0 0 202118_s_at CPNE3 copine III -0.22 0.23 0.17 0.18 1 1 -1 0 0 0 1 0 0 1 0 1 212650_at EHBP1 EH domain binding protein 1 -0.15 0.19 0.17 0.14 1 1 -1 0 0 0 1 0 0 1 0 1 213457_at MFHAS1 malignant fibrous histiocytoma amplified sequence 1 -0.50 -0.21 -0.31 -0.26 1 1 -1 0 0 0 0 0 0 1 0 0 214615_at P2RY10 purinergic receptor P2Y, G-protein coupled, 10 -0.35 -0.08 -0.11 -0.13 1 1 -1 0 0 0 0 0 0 1 0 0 223079_s_at GLS glutaminase -0.55 -0.22 -0.26 -0.26 1 1 -1 0 0 0 1 0 0 1 0 1 226367_at KDM5A lysine (K)-specific demethylase 5A -0.35 -0.02 -0.16 -0.07 1 1 -1 0 0 0 0 0 0 1 0 1 231597_x_at ------0.67 0.37 0.91 0.32 1 1 0 0 1 0 0 0 1 0 1 1 231934_at TRIM14 tripartite motif-containing 14 -0.28 -0.02 -0.10 -0.07 1 1 -1 0 0 0 0 0 0 1 0 0 233387_s_at PCNT pericentrin -0.26 -0.08 0.14 -0.13 0 1 0 0 1 0 1 0 0 0 1 0 240951_at RORA RAR-related orphan receptor A -0.36 -0.13 -0.09 -0.18 0 1 -1 0 0 0 1 0 0 0 0 0 243940_at TSHZ2 teashirt zinc finger homeobox 2 -0.34 -0.02 -0.13 -0.07 1 1 -1 0 0 0 0 0 0 1 0 1 244171_at MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.66 -0.36 -0.43 -0.41 1 1 -1 0 0 0 0 0 0 1 0 0 244669_at SNHG5 /// SNORD50Asmall nucleolar /// SNORD50B RNA host gene 5 (non-protein coding) /// small nucleolar-0.02 RNA,0.40 C/D box0.48 50A ///0.35 small nucleolar1 RNA, 1C/D box 50B-1 0 0 0 1 0 0 1 0 1 1558678_s_at MALAT1 metastasis associated lung adenocarcinoma transcript 1 (non-protein-0.19 coding)-0.13 0.12 -0.17 0 1 0 0 1 0 1 0 0 0 1 0 1560144_at ------1.07 0.74 1.42 0.70 1 1 0 0 1 0 0 0 1 0 1 1 1569830_at PTPRC protein tyrosine phosphatase, receptor type, C -0.48 -0.20 -0.12 -0.24 1 1 -1 0 0 0 1 0 0 1 0 0 201711_x_at RANBP2 RAN binding protein 2 0.02 0.04 0.27 0.00 0 1 0 0 1 0 0 0 0 0 1 0 202412_s_at USP1 ubiquitin specific peptidase 1 0.23 0.27 0.51 0.23 0 1 0 0 1 0 1 0 0 0 1 0 208664_s_at TTC3 tetratricopeptide repeat domain 3 -0.36 0.00 0.09 -0.04 1 1 -1 0 0 0 1 0 0 1 0 1 211821_x_at GYPA glycophorin A (MNS blood group) 0.43 0.33 0.60 0.28 1 1 0 0 1 0 0 0 1 0 1 0 220946_s_at SETD2 SET domain containing 2 -0.45 0.01 0.07 -0.03 1 1 -1 0 0 0 1 0 0 1 0 1 222600_s_at UBA6 ubiquitin-like modifier activating enzyme 6 -0.45 -0.14 -0.20 -0.18 1 1 -1 0 0 0 0 0 0 1 0 1 236728_at LNPEP leucyl/cystinyl aminopeptidase -0.16 0.10 0.21 0.06 1 1 -1 0 0 0 1 0 0 1 0 0 237502_at CRLS1 cardiolipin synthase 1 -0.46 -0.07 -0.14 -0.12 1 1 -1 0 0 0 1 0 0 1 0 1 239674_at ARID1B AT rich interactive domain 1B (SWI1-like) -0.33 -0.06 -0.15 -0.10 1 1 -1 0 0 0 0 0 0 1 0 0 241403_at CLK4 CDC-like kinase 4 -0.52 -0.13 -0.01 -0.17 1 1 -1 0 0 0 1 0 0 1 0 1 241620_at SMCHD1 structural maintenance of chromosomes flexible hinge domain containing-0.22 10.06 0.17 0.03 1 1 -1 0 0 0 1 0 0 1 0 0 1558702_at TEX10 testis expressed 10 -0.38 -0.16 -0.05 -0.19 0 1 -1 0 0 0 1 0 0 0 0 0 1569791_at STK4 serine/threonine kinase 4 -0.36 -0.05 -0.06 -0.08 1 1 -1 0 0 0 1 0 0 1 0 1 1570371_a_at EPT1 Ethanolaminephosphotransferase 1 (CDP-ethanolamine-specific) -0.15 -0.04 0.17 -0.06 0 1 0 0 1 0 1 0 0 0 0 0 201635_s_at FXR1 fragile X mental retardation, autosomal homolog 1 -0.55 -0.14 -0.07 -0.17 1 1 -1 0 0 0 1 0 0 1 0 1 209060_x_at NCOA3 nuclear receptor coactivator 3 -0.26 -0.04 0.04 -0.07 0 1 -1 0 0 0 1 0 0 0 0 0 210693_at SPPL2B signal peptide peptidase-like 2B -0.04 0.22 0.24 0.18 0 1 -1 0 0 0 1 0 0 0 0 0 212758_s_at ZEB1 zinc finger E-box binding homeobox 1 -0.14 0.00 0.17 -0.03 0 1 0 0 1 0 1 0 0 0 0 0 222343_at BCL2L11 BCL2-like 11 (apoptosis facilitator) -0.12 0.11 0.21 0.08 0 1 -1 0 0 0 1 0 0 0 0 0 226404_at RBM39 RNA binding motif protein 39 -0.14 0.19 0.13 0.16 1 1 -1 0 0 0 1 0 0 1 0 1 239504_at LOC731605 /// similarBCLAF1 to Bcl-2-associated transcription factor 1 (Btf); BCL2-associated-0.35 transcription-0.01 0.02factor 1-0.04 1 1 -1 0 0 0 1 0 0 1 0 1 240401_at AATF apoptosis antagonizing transcription factor -0.10 0.19 0.13 0.16 1 1 -1 0 0 0 0 0 0 1 0 0 243473_at SIK3 serine/threonine-protein kinase QSK -0.62 -0.27 -0.37 -0.30 1 1 -1 0 0 0 0 0 0 1 0 1 244055_at RYR3 ryanodine receptor 3 -0.31 0.01 -0.10 -0.01 1 1 -1 0 0 0 0 0 0 1 0 1 208965_s_at IFI16 interferon, gamma-inducible protein 16 0.01 0.23 0.37 0.21 0 1 -1 0 0 0 1 0 0 0 0 0 209715_at CBX5 chromobox homolog 5 -0.39 -0.13 -0.11 -0.15 0 1 -1 0 0 0 1 0 0 0 0 0 209750_at NR1D2 nuclear receptor subfamily 1, group D, member 2 -0.27 0.03 0.06 0.01 1 1 -1 0 0 0 1 0 0 1 0 1 211993_at WNK1 WNK lysine deficient protein kinase 1 -0.75 -0.25 -0.16 -0.26 1 1 -1 0 0 0 1 0 0 1 0 1 215220_s_at TPR translocated promoter region (to activated MET oncogene) -0.67 -0.17 -0.04 -0.19 1 1 -1 0 0 0 1 0 0 1 0 1 215339_at NKTR natural killer-tumor recognition sequence -0.14 0.30 0.14 0.27 1 1 -1 0 0 0 0 0 0 1 0 1 236645_at LOC100506312hypothetical LOC100506312 -0.41 0.00 -0.05 -0.02 1 1 -1 0 0 0 1 0 0 1 0 1 242422_at G3BP1 GTPase activating protein (SH3 domain) binding protein 1 -0.57 -0.15 -0.09 -0.16 1 1 -1 0 0 0 1 0 0 1 0 1 242970_at DIP2B DIP2 disco-interacting protein 2 homolog B (Drosophila) -0.44 -0.18 -0.15 -0.20 1 1 -1 0 0 0 1 0 0 1 0 0 243767_at ------0.38 -0.04 -0.10 -0.06 1 1 -1 0 0 0 1 0 0 1 0 1 244035_at BCL2 B-cell CLL/lymphoma 2 -0.36 -0.01 0.06 -0.03 1 1 -1 0 0 0 1 0 0 1 0 1 1570213_at ------0.32 0.31 0.60 0.30 1 1 0 0 1 0 1 0 1 0 1 0 207237_at KCNA3 potassium voltage-gated channel, shaker-related subfamily, member-0.29 3 0.08 0.11 0.06 1 1 -1 0 0 0 1 0 0 1 0 1 208601_s_at TUBB1 tubulin, beta 1 0.38 0.54 0.80 0.53 0 1 0 0 1 0 1 0 0 0 1 0 215698_at KDM5A lysine (K)-specific demethylase 5A -0.78 -0.32 -0.43 -0.33 1 1 -1 0 0 0 1 0 0 1 0 1 216101_at ------0.19 0.03 0.20 0.02 0 1 -1 0 0 0 1 0 0 0 0 0 216901_s_at IKZF1 IKAROS family zinc finger 1 (Ikaros) -0.61 -0.29 -0.11 -0.30 0 1 -1 0 1 0 1 0 0 0 0 1 217602_at PPIA peptidylprolyl isomerase A (cyclophilin A) -0.13 0.12 0.19 0.12 0 1 -1 0 0 0 1 0 0 0 0 0 230014_at YPEL5 yippee-like 5 (Drosophila) -0.34 0.02 0.14 0.01 1 1 -1 0 0 0 1 0 0 1 0 1 231862_at CBX5 chromobox homolog 5 -0.37 -0.08 -0.08 -0.09 1 1 -1 0 0 0 1 0 0 1 0 1 234632_x_at BTNL8 butyrophilin-like 8 0.22 0.21 0.50 0.20 0 1 0 0 1 0 0 0 0 0 1 0 237689_at SARS Seryl-tRNA synthetase -0.28 0.05 -0.05 0.04 1 1 -1 0 0 0 0 0 0 1 0 1 239978_at PITPNB phosphatidylinositol transfer protein, beta -0.25 0.05 -0.05 0.04 1 1 -1 0 0 0 0 0 0 1 0 1 240015_at LOC439949 hypothetical LOC439949 0.08 0.36 0.36 0.35 1 1 -1 0 0 0 1 0 0 1 0 1 240078_at SFSWAP splicing factor, suppressor of white-apricot homolog (Drosophila) -0.30 0.00 -0.01 -0.01 1 1 -1 0 0 0 1 0 0 1 0 1 241462_at ------0.18 0.63 0.55 0.62 1 1 -1 0 0 0 1 0 0 1 0 1 1557519_at CDC42SE2 CDC42 small effector 2 -0.21 0.10 0.04 0.09 1 1 -1 0 0 0 0 0 0 1 0 1 200806_s_at HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.19 -0.20 0.11 -0.20 1 1 0 0 1 0 1 0 1 0 1 0

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206500_s_at C14orf106 chromosome 14 open reading frame 106 -0.24 0.05 0.16 0.05 1 1 -1 0 0 0 1 0 0 1 0 1 206668_s_at SCAMP1 secretory carrier membrane protein 1 -0.50 -0.22 -0.05 -0.22 1 1 -1 0 1 0 1 0 0 1 0 1 209446_s_at C7orf44 chromosome 7 open reading frame 44 -1.10 -0.99 -1.28 -0.99 1 1 0 0 -1 0 0 0 1 0 1 0 210800_at TIMM8A translocase of inner mitochondrial membrane 8 homolog A (yeast)0.57 0.50 0.80 0.50 1 1 0 0 1 0 0 0 1 0 1 0 214251_s_at NUMA1 nuclear mitotic apparatus protein 1 -0.51 -0.19 -0.18 -0.19 1 1 -1 0 0 0 1 0 0 1 0 1 215342_s_at RABGAP1L RAB GTPase activating protein 1-like -0.13 0.07 0.25 0.07 0 1 -1 0 1 0 1 0 0 0 0 0 221765_at UGCG UDP-glucose ceramide glucosyltransferase -0.76 -0.33 -0.31 -0.33 1 1 -1 0 0 0 1 0 0 1 0 1 223263_s_at FGFR1OP2 FGFR1 oncogene partner 2 -0.44 -0.09 -0.15 -0.09 1 1 -1 0 0 0 1 0 0 1 0 1 230106_at ZXDC ZXD family zinc finger C -0.11 0.02 0.20 0.02 0 1 0 0 1 0 1 0 0 0 0 0 230434_at PHOSPHO2 phosphatase, orphan 2 -0.21 0.05 0.09 0.05 0 1 -1 0 0 0 1 0 0 0 0 0 230820_at SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.35 0.00 -0.11 0.00 1 1 -1 0 0 0 0 0 0 1 0 1 232257_s_at C3orf20 chromosome 3 open reading frame 20 -1.04 -0.54 -0.76 -0.53 1 1 -1 0 0 0 1 0 0 1 0 1 233283_at Fntb farnesyltransferase, CAAX box, beta -0.20 0.13 0.06 0.13 1 1 -1 0 0 0 0 0 0 1 0 1 242496_at ------0.39 0.32 0.61 0.32 1 1 0 0 1 0 0 0 1 0 1 0 243182_at ------0.61 -0.34 -0.40 -0.34 1 1 -1 0 0 0 0 0 0 1 0 1 205809_s_at WASL Wiskott-Aldrich syndrome-like -0.72 -0.36 -0.43 -0.35 1 1 -1 0 0 0 1 0 0 1 0 1 206548_at ------1.13 -1.16 -1.42 -1.15 0 1 0 0 -1 0 0 0 0 0 1 0 207549_x_at CD46 CD46 molecule, complement regulatory protein -0.05 0.14 0.23 0.14 0 1 -1 0 0 0 1 0 0 0 0 0 213566_at RNASE6 ribonuclease, RNase A family, k6 -1.82 -2.09 -1.99 -2.08 0 1 1 0 0 0 0 0 0 0 0 1 224549_x_at SND1 staphylococcal nuclease and tudor domain containing 1 0.64 0.45 0.87 0.46 1 1 0 0 1 0 0 0 1 0 1 0 237184_at ATXN2 ataxin 2 -0.59 -0.27 -0.26 -0.26 1 1 -1 0 0 0 1 0 0 1 0 1 238706_at PAPD4 PAP associated domain containing 4 -0.31 0.04 -0.08 0.05 1 1 -1 0 0 0 0 0 0 1 0 1 243739_at RANBP9 RAN binding protein 9 -0.59 -0.17 -0.18 -0.16 1 1 -1 0 0 0 1 0 0 1 0 1 1555812_a_at ARHGDIB Rho GDP dissociation inhibitor (GDI) beta 0.39 0.22 0.64 0.24 1 1 0 0 1 0 0 0 1 0 1 0 1557236_at APOL6 apolipoprotein L, 6 -0.25 0.03 -0.04 0.05 1 1 -1 0 0 0 0 0 0 1 0 1 201083_s_at BCLAF1 BCL2-associated transcription factor 1 -0.36 -0.01 -0.04 0.01 1 1 -1 0 0 0 1 0 0 1 0 1 213875_x_at C6orf62 chromosome 6 open reading frame 62 -0.87 -0.64 -0.51 -0.62 0 1 -1 0 0 0 1 0 0 0 0 0 217644_s_at SOS2 son of sevenless homolog 2 (Drosophila) -0.97 -0.64 -0.49 -0.62 1 1 -1 0 0 0 1 0 0 1 0 1 225046_at LOC389831 hypothetical LOC389831 0.27 0.20 0.53 0.22 1 1 0 0 1 0 0 0 1 0 1 0 230466_s_at ------0.30 0.04 -0.11 0.07 1 1 -1 0 0 0 0 0 0 1 0 1 237784_at SUB1 SUB1 homolog (S. cerevisiae) -1.05 -0.49 -0.68 -0.47 1 1 -1 0 0 0 0 0 0 1 0 1 239351_at FKBP3 FK506 binding protein 3, 25kDa -0.45 -0.15 -0.20 -0.14 1 1 -1 0 0 0 0 0 0 1 0 1 241091_at ------0.63 -0.35 -0.36 -0.32 1 1 -1 0 0 0 1 0 0 1 0 1 201446_s_at TIA1 TIA1 cytotoxic granule-associated RNA binding protein -0.32 -0.07 -0.02 -0.04 0 1 -1 0 0 0 1 0 0 0 0 1 205596_s_at SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.19 0.10 -0.01 0.13 1 1 -1 0 0 0 0 0 0 1 0 1 206928_at ZNF124 zinc finger protein 124 -0.36 -0.10 0.00 -0.07 0 1 -1 0 0 0 1 0 0 0 0 1 218748_s_at EXOC5 exocyst complex component 5 -0.94 -0.67 -0.63 -0.64 1 1 -1 0 0 0 1 0 0 1 0 1 232472_at FNDC3B fibronectin type III domain containing 3B -1.53 -1.57 -1.84 -1.54 0 1 0 0 -1 0 0 0 0 0 1 0 238356_at DOCK11 dedicator of cytokinesis 11 -0.48 -0.14 -0.19 -0.11 1 1 -1 0 0 0 1 0 0 1 0 1 242588_at ------0.33 -0.02 -0.04 0.02 1 1 -1 0 0 0 1 0 0 1 0 1 1557227_s_at TPR translocated promoter region (to activated MET oncogene) -0.42 -0.15 0.25 -0.11 0 1 -1 0 1 0 1 0 0 0 1 1 206667_s_at SCAMP1 secretory carrier membrane protein 1 -0.60 -0.41 -0.24 -0.37 0 1 -1 0 0 0 1 0 0 0 0 0 212417_at SCAMP1 secretory carrier membrane protein 1 -0.50 -0.28 -0.20 -0.23 0 1 -1 0 0 0 1 0 0 0 0 1 214786_at MAP3K1 mitogen-activated protein kinase kinase kinase 1 -0.73 -0.22 -0.15 -0.19 1 1 -1 0 0 0 1 0 0 1 0 1 223890_at PRO1082 hypothetical protein PRO1082 -0.14 0.16 0.09 0.20 1 1 -1 0 0 0 0 0 0 1 0 1 227510_x_at MALAT1 metastasis associated lung adenocarcinoma transcript 1 (non-protein0.32 coding)0.19 0.64 0.23 1 1 0 0 1 0 1 0 1 0 1 0 1556226_at PDS5A PDS5, regulator of cohesion maintenance, homolog A (S. cerevisiae)-0.52 -0.16 -0.24 -0.11 1 1 -1 0 0 0 1 0 0 1 0 1 201450_s_at TIA1 TIA1 cytotoxic granule-associated RNA binding protein -0.22 0.03 -0.01 0.08 0 1 -1 0 0 0 0 0 0 0 0 1 210807_s_at SLC16A7 solute carrier family 16, member 7 (monocarboxylic acid transporter-0.30 2) -0.07 -0.04 -0.02 0 1 -1 0 0 0 0 0 0 0 0 1 222714_s_at LACTB2 lactamase, beta 2 -0.59 -0.35 -0.40 -0.30 0 1 -1 0 0 0 0 0 0 0 0 1 229399_at C10orf118 chromosome 10 open reading frame 118 -0.27 -0.08 0.23 -0.03 0 1 -1 0 1 0 1 0 0 0 0 0 235653_s_at THAP6 THAP domain containing 6 -0.52 -0.24 -0.10 -0.20 1 1 -1 0 0 0 1 0 0 1 0 1 239692_at ILKAP integrin-linked kinase-associated serine/threonine phosphatase 2C-0.65 -0.39 -0.18 -0.33 0 1 -1 0 0 0 1 0 0 0 0 1 240105_at GCFC1 chromosome 21 open reading frame 66 -0.25 0.11 0.22 0.16 1 1 -1 0 0 0 1 0 0 1 0 1 241532_at Rmnd5a required for meiotic nuclear division 5 homolog A (S. cerevisiae) -0.36 -0.12 -0.17 -0.08 0 1 -1 0 0 0 0 0 0 0 0 1 1557436_at XKR6 XK, Kell blood group complex subunit-related family, member 6 -0.45 -0.17 -0.09 -0.11 1 1 -1 0 0 0 1 0 0 1 0 1 1565913_at ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.12 0.16 0.23 0.21 1 1 -1 0 0 0 1 0 0 1 0 1 205885_s_at ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)-0.46 -0.11 -0.23 -0.05 1 1 -1 0 0 0 0 0 0 1 0 1 210717_at ube2d2 ubiquitin-conjugating enzyme E2D 2 (UBC4/5 homolog, yeast) -0.43 -0.09 -0.09 -0.03 1 1 -1 0 0 0 1 0 0 1 0 1 220771_at LOC51152 melanoma antigen 0.38 0.20 0.58 0.26 1 1 0 0 1 0 0 0 1 0 1 0 227345_at TNFRSF10D tumor necrosis factor receptor superfamily, member 10d, decoy with-0.97 truncated-0.93 death-1.17 domain-0.87 0 1 0 0 -1 0 0 0 0 0 1 0 242989_at ------0.33 -0.09 -0.15 -0.03 0 1 -1 0 0 0 0 0 0 0 0 1 243552_at MBTD1 mbt domain containing 1 -0.40 -0.16 -0.08 -0.09 0 1 -1 0 0 0 1 0 0 0 0 1 243959_at MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.69 -0.36 -0.30 -0.31 1 1 -1 0 0 0 1 0 0 1 0 1 201008_s_at TXNIP thioredoxin interacting protein -0.27 -0.24 0.01 -0.18 0 1 0 0 1 0 1 0 0 0 0 0 223254_s_at G2E3 G2/M-phase specific E3 ubiquitin protein ligase -0.53 -0.33 -0.18 -0.26 0 1 -1 0 0 0 1 0 0 0 0 1 228986_at OSBPL8 oxysterol binding protein-like 8 -0.73 -0.43 -0.25 -0.36 0 1 -1 0 0 0 1 0 0 0 0 1 231370_at PPM1A Protein phosphatase, Mg2+/Mn2+ dependent, 1A -0.88 -0.42 -0.66 -0.35 1 1 -1 0 0 0 0 0 0 1 1 1 237747_at fam107b family with sequence similarity 107, member B -0.44 -0.24 -0.25 -0.17 0 1 -1 0 0 0 0 0 0 0 0 1 243631_at MPHOSPH8 M-phase phosphoprotein 8 0.07 0.27 0.38 0.33 0 1 -1 0 0 0 1 0 0 0 0 0 244263_at ------0.46 -0.28 -0.17 -0.22 0 1 -1 0 0 0 1 0 0 0 0 0 210218_s_at SP100 SP100 nuclear antigen -0.76 -0.44 -0.39 -0.35 1 1 -1 0 0 0 1 0 0 1 0 1 232125_at ------0.44 -0.13 0.01 -0.05 1 1 -1 0 0 0 1 0 0 1 0 1 232757_at mtss1 metastasis suppressor 1 -0.15 -0.15 -0.43 -0.07 0 1 0 0 -1 0 0 0 0 0 1 0 237376_at cul3 cullin 3 -0.48 -0.18 -0.14 -0.10 1 1 -1 0 0 0 0 0 0 1 0 1 241889_at NFKBID nuclear factor of kappa light polypeptide gene enhancer in B-cells -0.32inhibitor,-0.10 delta 0.03 -0.02 0 1 -1 0 0 0 1 0 0 0 0 1 1556471_at SCML4 sex comb on midleg-like 4 (Drosophila) 0.10 0.28 0.29 0.37 0 1 -1 0 0 0 0 0 0 0 0 1 1558093_s_at MATR3 matrin 3 -0.52 -0.42 -0.11 -0.33 1 1 0 0 1 0 1 0 1 0 0 0 210057_at SMG1 SMG1 homolog, phosphatidylinositol 3-kinase-related kinase (C. elegans)-0.77 -0.46 -0.42 -0.37 1 1 -1 0 0 0 1 0 0 1 0 1 217656_at SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin,-0.14 0.04 subfamily0.07 a, member0.13 4 0 1 -1 0 0 0 0 0 0 0 0 1 240141_at papd4 PAP associated domain containing 4 -0.60 -0.30 -0.24 -0.21 1 1 -1 0 0 0 1 0 0 1 0 1 1562230_at ------0.30 -0.11 -0.10 -0.01 0 1 -1 0 0 0 0 0 0 0 0 1 1564053_a_at YTHDF3 YTH domain family, member 3 -0.91 -0.70 -0.74 -0.60 0 1 -1 0 0 0 0 0 0 0 0 1 206652_at ZMYM5 zinc finger, MYM-type 5 -0.38 -0.19 -0.12 -0.09 0 1 -1 0 0 0 0 0 0 0 0 1 214881_s_at UBTF upstream binding transcription factor, RNA polymerase I 0.13 0.10 0.37 0.20 1 1 0 0 1 0 0 0 1 0 0 0 216527_at ------0.39 -0.17 -0.09 -0.07 0 1 -1 0 0 0 1 0 0 0 0 1 218967_s_at PTER phosphotriesterase related -0.34 -0.13 -0.11 -0.03 0 1 -1 0 0 0 0 0 0 0 0 1 227777_at C10orf18 chromosome 10 open reading frame 18 -0.59 -0.39 -0.35 -0.30 0 1 -1 0 0 0 0 0 0 0 0 1 227884_at TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated-0.08 factor,0.14 68kDa 0.15 0.24 0 1 -1 0 0 0 0 0 0 0 0 1 207686_s_at CASP8 caspase 8, apoptosis-related cysteine peptidase -0.30 -0.13 -0.09 -0.02 0 1 -1 0 0 0 0 0 0 0 0 1 211794_at FYB FYN binding protein -0.08 0.18 0.18 0.28 0 1 -1 0 0 0 0 0 0 0 0 1 219797_at MGAT4A mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase,-0.73 -0.44 isozyme-0.36 A -0.33 1 1 -1 0 0 0 1 0 0 1 0 1 232179_at LOC158863 Hypothetical protein LOC158863 -0.91 -0.47 -0.56 -0.36 1 1 -1 0 0 0 0 0 0 1 0 1 233819_s_at LTN1 listerin E3 ubiquitin protein ligase 1 -0.93 -0.49 -0.41 -0.38 1 1 -1 0 0 0 1 0 0 1 0 1 212398_at RDX radixin -0.89 -0.63 -0.65 -0.51 0 1 -1 0 0 0 0 0 0 0 0 1 212392_s_at PDE4DIP phosphodiesterase 4D interacting protein -1.00 -0.85 -0.54 -0.72 0 1 0 0 1 0 1 0 0 0 0 1 235430_at C14orf43 chromosome 14 open reading frame 43 -0.45 -0.15 -0.01 -0.02 1 1 -1 0 0 0 1 0 0 1 0 1 240602_at HBS1L HBS1-like (S. cerevisiae) -0.88 -0.54 -0.61 -0.41 1 1 -1 0 0 0 0 0 0 1 0 1 244508_at SEPT7 Septin 7 -0.41 -0.17 -0.08 -0.04 0 1 -1 0 0 0 1 0 0 0 0 1 244846_at MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.30 -0.02 0.03 0.10 1 1 -1 0 0 0 1 0 0 1 0 1 209203_s_at BICD2 bicaudal D homolog 2 (Drosophila) -0.63 -0.45 -0.36 -0.31 0 1 -1 0 0 0 1 0 0 0 0 1 236386_at LOC100506501hypothetical LOC100506501 -0.69 -0.44 -0.41 -0.30 0 1 -1 0 0 0 1 0 0 0 0 1 244443_at CHD2 Chromodomain helicase DNA binding protein 2 -0.02 0.20 0.17 0.34 0 1 -1 0 0 0 0 0 0 0 0 1 1558111_at MBNL1 muscleblind-like (Drosophila) -0.14 0.04 0.10 0.20 0 1 -1 0 0 0 0 0 0 0 0 1 204180_s_at ZBTB43 zinc finger and BTB domain containing 43 -0.71 -0.50 -0.52 -0.35 0 1 -1 0 0 0 0 0 0 0 0 1 224227_s_at BDP1 B double prime 1, subunit of RNA polymerase III transcription initiation-0.30 factor-0.06 IIIB 0.09 0.09 0 1 -1 0 0 0 0 0 0 0 0 1 224989_at C4orf34 chromosome 4 open reading frame 34 -0.48 -0.24 -0.24 -0.10 0 1 -1 0 0 0 0 0 0 0 0 1 229115_at DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 -0.52 -0.34 0.00 -0.19 1 1 -1 0 1 0 1 0 1 0 0 1 243835_at ZDHHC21 zinc finger, DHHC-type containing 21 -0.22 -0.13 0.21 0.01 1 1 0 0 1 0 1 0 1 0 0 0

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1553185_at RASEF RAS and EF-hand domain containing 0.45 0.28 0.62 0.44 1 1 0 0 1 0 0 0 1 0 0 0 202609_at EPS8 epidermal growth factor receptor pathway substrate 8 -0.40 -0.01 -0.22 0.15 1 1 -1 0 0 0 0 0 0 1 0 1 208797_s_at GOLGA8A golgin A8 family, member A -0.11 0.10 0.42 0.26 1 1 -1 0 0 0 1 0 1 0 0 1 1554250_s_at TRIM73 tripartite motif-containing 73 -0.10 0.01 -0.08 0.18 0 1 0 0 0 1 0 0 0 0 1 1 1554770_x_at ZNF785 zinc finger protein 785 -0.49 -0.31 -0.46 -0.14 0 1 0 0 0 1 0 0 0 0 1 1 204995_at CDK5R1 cyclin-dependent kinase 5, regulatory subunit 1 (p35) 0.17 0.28 0.25 0.45 0 1 0 0 0 1 0 0 0 0 0 1 210942_s_at ST3GAL6 ST3 beta-galactoside alpha-2,3-sialyltransferase 6 -1.59 -1.26 -1.40 -1.08 0 1 -1 0 0 1 0 0 0 0 0 1 216683_at tbca tubulin folding cofactor A -0.36 -0.27 -0.31 -0.09 0 1 0 0 0 1 0 0 0 0 0 1 217540_at FAM55C family with sequence similarity 55, member C -0.39 -0.25 -0.29 -0.08 0 1 0 0 0 1 0 0 0 0 0 1 221986_s_at KLHL24 kelch-like 24 (Drosophila) -0.52 -0.31 -0.18 -0.15 0 1 -1 0 0 0 1 0 0 0 0 1 223578_x_at MALAT1 metastasis associated lung adenocarcinoma transcript 1 (non-protein0.76 coding)0.46 0.96 0.63 1 1 0 -1 1 0 0 0 1 0 0 0 226550_at ------0.66 -0.54 -0.59 -0.36 0 1 0 0 0 1 0 0 0 0 0 1 232980_at LMBRD1 LMBR1 domain containing 1 -0.15 -0.06 -0.09 0.11 0 1 0 0 0 1 0 0 0 0 0 1 1554910_at PRKD3 protein kinase D3 -0.37 -0.24 -0.27 -0.06 0 1 0 0 0 1 0 0 0 0 0 1 1559289_at TADA1 Transcriptional adaptor 1 -0.44 -0.31 -0.39 -0.13 0 1 0 0 0 1 0 0 0 0 1 1 1564789_at ------0.76 -0.72 -0.93 -0.54 0 1 0 0 -1 1 0 0 0 0 1 0 1565875_at ------0.13 0.01 -0.14 0.19 0 1 0 0 0 1 0 0 0 0 1 1 1569431_at PAFAH1B2 platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 (30kDa)-0.36 -0.37 -0.47 -0.19 0 1 0 0 0 1 0 0 0 0 1 0 204956_at MTAP methylthioadenosine phosphorylase -0.06 0.07 0.04 0.25 0 1 0 0 0 1 0 0 0 0 0 1 207907_at TNFSF14 tumor necrosis factor (ligand) superfamily, member 14 -2.27 -2.23 -2.39 -2.05 0 1 0 0 0 1 0 0 0 0 1 0 215188_at STK24 serine/threonine kinase 24 -1.11 -0.91 -0.94 -0.73 0 1 -1 0 0 1 0 0 0 0 0 1 222473_s_at ERBB2IP erbb2 interacting protein -0.32 -0.22 -0.27 -0.04 0 1 0 0 0 1 0 0 0 0 0 1 225237_s_at MSI2 musashi homolog 2 (Drosophila) -0.48 -0.38 -0.48 -0.20 0 1 0 0 0 1 0 0 0 0 1 1 227719_at SMAD9 SMAD family member 9 -0.38 -0.16 -0.20 0.02 0 1 -1 0 0 1 0 0 0 0 0 1 229732_at ZNF823 zinc finger protein 823 0.03 0.13 0.07 0.31 0 1 0 0 0 1 0 0 0 0 0 1 229966_at EWSR1 Ewing sarcoma breakpoint region 1 -0.44 -0.21 -0.44 -0.02 0 1 0 0 0 1 0 0 0 0 1 1 231995_at C9orf82 chromosome 9 open reading frame 82 -0.28 -0.14 -0.22 0.05 0 1 0 0 0 1 0 0 0 0 0 1 233664_at ARL15 ADP-ribosylation factor-like 15 -0.63 -0.64 -0.75 -0.46 0 1 0 0 0 1 0 0 0 0 1 0 235803_at CRLF3 cytokine receptor-like factor 3 -0.51 -0.43 -0.52 -0.25 0 1 0 0 0 1 0 0 0 0 1 0 241275_at CAPZA1 Capping protein (actin filament) muscle Z-line, alpha 1 -0.50 -0.36 -0.38 -0.18 0 1 0 0 0 1 0 0 0 0 0 1 244674_at RBM6 RNA binding motif protein 6 -0.73 -0.51 -0.67 -0.33 0 1 0 0 0 1 0 0 0 0 1 1 1569129_s_at C3orf38 chromosome 3 open reading frame 38 -0.21 -0.14 -0.24 0.05 0 1 0 0 0 1 0 0 0 0 1 1 1569472_s_at TTC3 tetratricopeptide repeat domain 3 -0.26 -0.09 0.32 0.10 1 1 -1 0 1 0 1 0 1 0 0 1 203548_s_at LPL lipoprotein lipase -2.69 -2.72 -2.92 -2.53 0 1 0 0 -1 0 0 0 0 0 1 0 219730_at MED18 mediator complex subunit 18 -1.10 -0.90 -1.04 -0.71 0 1 0 0 0 1 0 0 0 0 1 1 228988_at ZNF711 zinc finger protein 711 -0.15 -0.07 -0.08 0.11 0 1 0 0 0 1 0 0 0 0 0 1 235052_at ZNF792 zinc finger protein 792 0.08 0.18 0.13 0.37 0 1 0 0 0 1 0 0 0 0 0 1 236202_at ------0.24 -0.10 -0.09 0.09 0 1 0 0 0 1 0 0 0 0 0 1 239778_x_at CAPN7 calpain 7 -0.09 -0.01 0.00 0.18 0 1 0 0 0 1 0 0 0 0 0 1 240265_at TRAF3IP3 TRAF3 interacting protein 3 0.00 0.12 -0.02 0.31 0 1 0 0 0 1 0 0 0 0 1 1 241863_x_at ttc14 tetratricopeptide repeat domain 14 -0.23 -0.01 -0.17 0.18 0 1 0 0 0 1 0 0 0 0 1 1 242289_at ------0.02 0.05 -0.02 0.25 0 1 0 0 0 1 0 0 0 0 1 1 243570_at SPCS2 signal peptidase complex subunit 2 homolog (S. cerevisiae) -0.61 -0.52 -0.55 -0.33 0 1 0 0 0 1 0 0 0 0 0 1 1555116_s_at SLC11A1 solute carrier family 11 (proton-coupled divalent metal ion transporters),-2.39 member-2.71 1-2.51 -2.51 1 1 0 -1 0 0 0 0 0 1 0 0 1568865_at FNTB Farnesyltransferase, CAAX box, beta -0.14 -0.15 -0.23 0.05 0 1 0 0 0 1 0 0 0 0 1 0 205684_s_at DENND4C DENN/MADD domain containing 4C -0.37 -0.40 -0.47 -0.19 0 1 0 0 0 1 0 0 0 0 1 0 220038_at C8orf44 /// SGK3chromosome 8 open reading frame 44 /// serum/glucocorticoid regulated-1.21 kinase-1.22 family,-1.33 member-1.02 3 0 1 0 0 0 1 0 0 0 0 1 0 228654_at SPIN4 spindlin family, member 4 -0.64 -0.52 -0.56 -0.32 0 1 0 0 0 1 0 0 0 0 0 1 228905_at PCM1 pericentriolar material 1 -0.01 0.09 0.07 0.29 0 1 0 0 0 1 0 0 0 0 0 1 229075_at SPATA5 spermatogenesis associated 5 -0.27 -0.21 -0.33 -0.01 0 1 0 0 0 1 0 0 0 0 1 0 232648_at PSMA3 proteasome (prosome, macropain) subunit, alpha type, 3 -0.51 -0.23 -0.25 -0.03 1 1 -1 0 0 1 0 0 0 1 0 1 235060_at LOC100190986hypothetical LOC100190986 -0.50 -0.36 -0.33 -0.16 0 1 0 0 0 1 0 0 0 0 0 1 240271_at mtmr3 myotubularin related protein 3 -0.66 -0.58 -0.61 -0.39 0 1 0 0 0 1 0 0 0 0 0 1 240789_at WDR44 WD repeat domain 44 -0.21 -0.20 -0.29 0.00 0 1 0 0 0 1 0 0 0 0 1 0 244763_at MTRF1 mitochondrial translational release factor 1 -0.33 -0.20 -0.24 0.00 0 1 0 0 0 1 0 0 0 0 0 1 1565692_at ------0.26 -0.18 -0.20 0.03 0 1 0 0 0 1 0 0 0 0 0 1 1570115_at PP12708 hypothetical LOC100130609 -0.26 -0.17 -0.17 0.05 0 1 0 0 0 1 0 0 0 0 0 1 214740_at POLR2J /// POLR2J2polymerase /// POLR2J3 (RNA) II (DNA directed) polypeptide J, 13.3kDa /// polymerase-0.74 -0.46(RNA) II (DNA-0.50 directed)-0.25 polypeptide0 J2 ///1 polymerase-1 (RNA) II0 (DNA directed)0 polypeptide1 J30 0 0 0 0 1 219858_s_at MFSD6 major facilitator superfamily domain containing 6 -1.25 -0.92 -0.98 -0.70 1 1 -1 0 0 1 0 0 0 1 1 1 232614_at BCL2 B-cell CLL/lymphoma 2 -0.12 -0.09 -0.19 0.12 0 1 0 0 0 1 0 0 0 0 1 0 233713_at SMYD2 SET and MYND domain containing 2 0.06 0.17 0.14 0.38 0 1 0 0 0 1 0 0 0 0 0 1 237890_at Dtnbp1 dystrobrevin binding protein 1 -0.14 0.11 0.09 0.32 0 1 -1 0 0 1 0 0 0 0 0 1 238525_at DDX56 DEAD (Asp-Glu-Ala-Asp) box polypeptide 56 -0.23 -0.25 -0.31 -0.05 0 1 0 0 0 1 0 0 0 0 1 0 241680_at MBD3 methyl-CpG binding domain protein 3 -0.40 -0.39 -0.45 -0.17 0 1 0 0 0 1 0 0 0 0 1 0 241755_at UQCRC2 ubiquinol-cytochrome c reductase core protein II -0.96 -0.84 -0.88 -0.63 0 1 0 0 0 1 0 0 0 0 0 1 242563_at fchsd2 FCH and double SH3 domains 2 -0.09 -0.04 -0.15 0.17 0 1 0 0 0 1 0 0 0 0 1 0 244766_at LOC100271836SMG1 /// LOC440354 homolog, ///phosphatidylinositol LOC595101 /// LOC641298 3-kinase-related /// SMG1 kinase pseudogene-0.34 ///-0.27 PI-3-kinase-related-0.25 -0.06 kinase SMG-10 pseudogene1 /// 0PI-3-kinase-related0 0 kinase SMG-11 pseudogene0 /// SMG10 homolog,0 phosphatidylinositol0 0 3-kinase-related1 kinase pseudogene /// SMG1 homolog, phosphatidylinositol 3-kinase-related kinase (C. elegans) 1557538_at Med13l mediator complex subunit 13-like -0.50 -0.48 -0.54 -0.26 0 1 0 0 0 1 0 0 0 0 1 0 209790_s_at CASP6 caspase 6, apoptosis-related cysteine peptidase -0.02 0.05 -0.02 0.27 0 1 0 0 0 1 0 0 0 0 1 1 211310_at EZH1 enhancer of zeste homolog 1 (Drosophila) -0.42 -0.20 -0.19 0.02 0 1 -1 0 0 1 0 0 0 0 0 1 223771_at TMEM87A Transmembrane protein 87A 0.02 0.02 -0.04 0.25 0 1 0 0 0 1 0 0 0 0 1 0 231109_at CELF2 CUG triplet repeat, RNA binding protein 2 -0.26 -0.06 -0.04 0.16 0 1 -1 0 0 1 0 0 0 0 0 1 232885_at NCRNA00081 non-protein coding RNA 81 -0.33 -0.34 -0.39 -0.12 0 1 0 0 0 1 0 0 0 0 1 0 233400_at CCDC82 coiled-coil domain containing 82 -0.09 -0.04 -0.06 0.18 0 1 0 0 0 1 0 0 0 0 0 1 235469_at FAM133B /// LOC728066family with sequence similarity 133, member B /// family with sequence-0.13 similarity-0.05 133,-0.05 member0.17 B pseudogene0 1 0 0 0 1 0 0 0 0 0 1 235611_at SREK1 splicing regulatory glutamine/lysine-rich protein 1 -0.23 -0.07 -0.19 0.16 0 1 0 0 0 1 0 0 0 0 1 1 235811_at Mbnl1 muscleblind-like (Drosophila) -0.37 -0.21 -0.18 0.00 0 1 0 0 0 1 0 0 0 0 0 1 236558_at Mbnl1 muscleblind-like (Drosophila) -0.28 -0.18 -0.16 0.05 0 1 0 0 0 1 0 0 0 0 0 1 237333_at RBBP4 retinoblastoma binding protein 4 -0.57 -0.49 -0.49 -0.26 0 1 0 0 0 1 0 0 0 0 0 1 243537_at GIT2 G protein-coupled receptor kinase interacting ArfGAP 2 -0.28 -0.21 -0.24 0.01 0 1 0 0 0 1 0 0 0 0 0 1 244473_at Atf7 activating transcription factor 7 -0.51 -0.45 -0.42 -0.23 0 1 0 0 0 1 0 0 0 0 0 1 1558105_a_at ------0.62 -0.56 -0.58 -0.34 0 1 0 0 0 1 0 0 0 0 0 1 1559580_at LRRC39 leucine rich repeat containing 39 -0.19 -0.15 -0.18 0.07 0 1 0 0 0 1 0 0 0 0 0 1 1559731_x_at MACROD1 MACRO domain containing 1 -0.22 -0.15 -0.17 0.09 0 1 0 0 0 1 0 0 0 0 0 1 1559932_at ------0.40 -0.26 -0.22 -0.04 0 1 0 0 0 1 0 0 0 0 0 1 1562364_at GVIN1 GTPase, very large interferon inducible 1 -0.43 0.04 0.06 0.27 1 1 -1 0 0 1 1 0 0 1 0 1 1562457_at NCKAP5L NCK-associated protein 5-like -0.47 -0.38 -0.44 -0.15 0 1 0 0 0 1 0 0 0 0 1 1 1565886_at TRPM7 transient receptor potential cation channel, subfamily M, member-0.23 7 -0.21 -0.25 0.02 0 1 0 0 0 1 0 0 0 0 1 0 213355_at ST3GAL6 ST3 beta-galactoside alpha-2,3-sialyltransferase 6 -1.65 -1.28 -1.48 -1.05 1 1 -1 0 0 1 0 0 0 1 1 1 214724_at DIXDC1 DIX domain containing 1 -1.30 -1.24 -1.24 -1.00 0 1 0 0 0 1 0 0 0 0 0 1 232412_at FBXL20 F-box and leucine-rich repeat protein 20 -1.23 -1.06 -1.15 -0.83 0 1 0 0 0 1 0 0 0 0 0 1 235652_at SCML1 sex comb on midleg-like 1 (Drosophila) 0.00 0.11 0.07 0.35 0 1 0 0 0 1 0 0 0 0 1 1 237232_at Ube2h ubiquitin-conjugating enzyme E2H (UBC8 homolog, yeast) -0.79 -0.68 -0.82 -0.45 0 1 0 0 0 1 0 0 0 0 1 1 239867_at C19orf2 chromosome 19 open reading frame 2 -0.50 -0.28 -0.30 -0.05 0 1 -1 0 0 1 0 0 0 0 0 1 241263_at ------0.86 -0.76 -0.81 -0.52 0 1 0 0 0 1 0 0 0 0 1 1 1556750_at LOC153577 hypothetical protein LOC153577 -1.28 -1.14 -1.22 -0.90 0 1 0 0 0 1 0 0 0 0 1 1 1560556_a_at PLEKHA8 Pleckstrin homology domain containing, family A (phosphoinositide-0.20 binding-0.19 specific)-0.27 member0.06 8 0 1 0 0 0 1 0 0 0 0 1 0 1563461_at ------0.95 -0.90 -1.07 -0.66 0 1 0 0 0 1 0 0 0 0 1 1 216022_at LOC100132369WNK /// WNK1 lysine deficient protein kinase 1; hypothetical LOC100132369-0.40 -0.31 -0.34 -0.07 0 1 0 0 0 1 0 0 0 0 1 1 218362_s_at DIS3 DIS3 mitotic control homolog (S. cerevisiae) -0.33 -0.34 -0.39 -0.09 0 1 0 0 0 1 0 0 0 0 1 0 225746_at RAB11FIP4 RAB11 family interacting protein 4 (class II) -0.44 -0.37 -0.39 -0.13 0 1 0 0 0 1 0 0 0 0 0 1 60794_f_at ZNF814 zinc finger protein 814 -0.51 -0.42 -0.37 -0.18 0 1 0 0 0 1 0 0 0 0 0 1 1554769_at ZNF785 zinc finger protein 785 -0.56 -0.43 -0.55 -0.18 0 1 0 0 0 1 0 0 0 0 1 1 1559455_at ------0.46 -0.38 -0.50 -0.13 0 1 0 0 0 1 0 0 0 0 1 1 1560755_at Fam149b1 family with sequence similarity 149, member B1 -0.24 -0.21 -0.23 0.04 0 1 0 0 0 1 0 0 0 0 1 1 1561154_at GBF1 golgi-specific brefeldin A resistant guanine nucleotide exchange factor-0.41 1 -0.36 -0.36 -0.11 0 1 0 0 0 1 0 0 0 0 0 1 1563077_at LOC100289058Hypothetical protein LOC100289058 -0.46 -0.43 -0.41 -0.18 0 1 0 0 0 1 0 0 0 0 0 1 1568983_a_at ------0.17 -0.15 -0.22 0.10 0 1 0 0 0 1 0 0 0 0 1 1 211934_x_at GANAB glucosidase, alpha; neutral AB 0.12 -0.19 0.00 0.06 1 1 0 -1 0 0 0 0 0 1 0 0

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214815_at TRIM33 tripartite motif-containing 33 -0.24 -0.26 -0.28 -0.01 0 1 0 0 0 1 0 0 0 0 1 0 220467_at ------0.06 -0.05 -0.09 0.20 0 1 0 0 0 1 0 0 0 0 1 0 224151_s_at AK3 adenylate kinase 3 -0.03 -0.01 0.03 0.24 0 1 0 0 0 1 0 0 0 0 0 1 224568_x_at MALAT1 metastasis associated lung adenocarcinoma transcript 1 (non-protein0.08 coding)0.02 0.85 0.26 1 1 0 0 1 0 1 0 1 0 1 0 233231_at MCCC2 Methylcrotonoyl-Coenzyme A carboxylase 2 (beta) -0.21 -0.17 -0.28 0.08 0 1 0 0 0 1 0 0 0 0 1 1 233419_at ------0.12 -0.17 -0.23 0.08 0 1 0 0 0 1 0 0 0 0 1 0 233630_at CDS2 CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2-0.11 -0.18 -0.20 0.07 0 1 0 0 0 1 0 0 0 0 1 0 236153_at ZNF280D zinc finger protein 280D 0.02 -0.05 -0.06 0.20 0 1 0 0 0 1 0 0 0 0 1 0 243751_at CHD2 chromodomain helicase DNA binding protein 2 -0.31 -0.30 -0.33 -0.05 0 1 0 0 0 1 0 0 0 0 1 0 1560177_at CCDC66 coiled-coil domain containing 66 -0.47 -0.44 -0.41 -0.18 0 1 0 0 0 1 0 0 0 0 0 1 203607_at INPP5F inositol polyphosphate-5-phosphatase F -0.43 -0.32 -0.36 -0.07 0 1 0 0 0 1 0 0 0 0 1 1 215128_at ------0.04 -0.13 -0.15 0.14 0 1 0 0 0 1 0 0 0 0 1 0 221771_s_at MPHOSPH8 M-phase phosphoprotein 8 -0.37 -0.37 -0.41 -0.11 0 1 0 0 0 1 0 0 0 0 1 0 226663_at ANKRD10 ankyrin repeat domain 10 -0.37 -0.34 -0.31 -0.08 0 1 0 0 0 1 0 0 0 0 0 1 239131_at ADNP activity-dependent neuroprotector homeobox -0.05 -0.01 -0.02 0.24 0 1 0 0 0 1 0 0 0 0 1 1 242490_at ------0.24 -0.31 -0.33 -0.05 0 1 0 0 0 1 0 0 0 0 1 0 239258_at rhoq /// RHOQP2ras homolog gene family, member Q; similar to small GTP binding -0.99protein TC10-0.98 -1.08 -0.70 0 1 0 0 0 1 0 0 0 0 1 1 204475_at MMP1 matrix metallopeptidase 1 (interstitial collagenase) -1.43 -0.84 -1.29 -0.54 0 1 0 0 0 1 0 0 0 0 1 1 220458_at ------0.43 -0.46 -0.52 -0.16 0 1 0 0 0 1 0 0 0 0 1 0 223940_x_at MALAT1 metastasis associated lung adenocarcinoma transcript 1 (non-protein0.45 coding)0.15 1.09 0.51 1 1 0 -1 1 0 0 0 1 0 1 0 206336_at CXCL6 chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein0.39 2) -0.39 -0.92 -1.00 0 1 1 0 0 0 1 0 0 0 0 1 219890_at CLEC5A C-type lectin domain family 5, member A -2.33 -2.63 -3.29 -3.19 0 1 1 0 0 0 1 0 0 0 0 1 216598_s_at CCL2 chemokine (C-C motif) ligand 2 -1.67 -2.11 -2.63 -2.67 0 1 1 0 0 0 1 0 0 0 0 1 203980_at FABP4 fatty acid binding protein 4, adipocyte -1.40 -1.83 -2.29 -2.37 0 1 1 0 0 0 0 0 0 0 0 1 212158_at SDC2 syndecan 2 -2.31 -2.81 -3.25 -3.32 0 1 1 0 0 0 1 0 0 0 0 1 203888_at THBD thrombomodulin -1.61 -2.05 -2.29 -2.51 0 1 1 0 0 -1 0 0 0 0 0 1 204620_s_at VCAN versican -2.61 -3.31 -3.62 -3.76 0 1 1 0 0 0 0 0 0 0 0 1 208075_s_at CCL7 chemokine (C-C motif) ligand 7 -2.54 -3.16 -3.58 -3.60 0 1 1 0 0 0 1 0 0 0 0 1 204619_s_at VCAN versican -2.58 -3.28 -3.53 -3.70 0 1 1 0 0 -1 0 0 0 0 0 1 221731_x_at VCAN versican -2.61 -3.34 -3.67 -3.76 0 1 1 0 0 0 0 0 0 0 0 1 215101_s_at CXCL5 chemokine (C-X-C motif) ligand 5 -0.44 -1.10 -1.17 -1.47 1 1 1 0 0 -1 0 0 0 1 0 1 204059_s_at ME1 malic enzyme 1, NADP(+)-dependent, cytosolic -0.63 -0.40 -1.11 -0.75 1 1 0 1 -1 0 0 0 1 0 0 0 212820_at DMXL2 Dmx-like 2 -1.09 -1.29 -1.68 -1.64 0 1 1 0 0 0 1 0 0 0 0 1 211571_s_at VCAN versican -2.64 -3.13 -3.29 -3.46 0 1 1 0 0 0 0 0 0 0 0 1 215646_s_at VCAN versican -2.83 -3.57 -3.76 -3.89 0 1 1 0 0 0 0 0 0 0 0 1 1565162_s_at MGST1 microsomal glutathione S-transferase 1 -2.37 -2.43 -3.02 -2.74 1 1 0 0 -1 0 1 0 1 0 0 1 208891_at DUSP6 dual specificity phosphatase 6 -1.39 -1.54 -2.03 -1.85 0 1 0 0 -1 0 1 0 0 0 0 1 212298_at NRP1 neuropilin 1 -1.86 -1.90 -2.53 -2.21 1 1 0 0 -1 0 1 0 1 0 0 0 203535_at S100A9 S100 calcium binding protein A9 -0.71 -1.02 -1.24 -1.32 0 1 1 0 0 0 1 0 0 0 0 1 219403_s_at HPSE heparanase -2.23 -2.45 -2.85 -2.75 0 1 1 0 0 0 1 0 0 0 0 1 226281_at DNER delta/notch-like EGF repeat containing -1.28 -1.54 -1.74 -1.84 0 1 1 0 0 0 0 0 0 0 0 1 202917_s_at S100A8 S100 calcium binding protein A8 -2.08 -2.51 -2.68 -2.80 0 1 1 0 0 0 0 0 0 0 0 1 208892_s_at DUSP6 dual specificity phosphatase 6 -1.43 -1.52 -2.02 -1.82 0 1 0 0 -1 0 1 0 0 0 0 1 210119_at KCNJ15 potassium inwardly-rectifying channel, subfamily J, member 15 -2.59 -2.77 -3.05 -3.06 0 1 1 0 0 0 0 0 0 0 0 1 228937_at C13orf31 chromosome 13 open reading frame 31 -0.91 -1.12 -1.49 -1.41 0 1 1 0 0 0 1 0 0 0 0 1 210772_at FPR2 formyl peptide receptor 2 -1.22 -1.62 -1.54 -1.89 1 1 1 0 0 -1 0 0 0 1 1 1 237252_at THBD thrombomodulin -1.15 -1.32 -1.46 -1.59 0 1 1 0 0 0 0 0 0 0 0 1 202437_s_at CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -2.12 -1.87 -2.59 -2.13 1 1 0 1 -1 0 0 0 1 0 0 0 204058_at ME1 malic enzyme 1, NADP(+)-dependent, cytosolic -0.80 -0.57 -1.22 -0.83 1 1 0 1 -1 0 0 0 1 0 0 0 221802_s_at KIAA1598 KIAA1598 -1.45 -1.63 -1.94 -1.89 0 1 1 0 0 0 1 0 0 0 0 1 225662_at ZAK sterile alpha motif and leucine zipper containing kinase AZK -0.77 -0.96 -1.33 -1.22 1 1 1 0 0 0 1 0 1 0 0 1 202435_s_at CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -2.04 -1.89 -2.51 -2.15 1 1 0 0 -1 0 0 0 1 0 0 0 204151_x_at AKR1C1 aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase-0.44 1; 20-alpha-0.29 (3-alpha)-hydroxysteroid-0.89 -0.55 1 dehydrogenase)1 0 0 -1 0 0 0 1 0 1 0 205576_at SERPIND1 serpin peptidase inhibitor, clade D (heparin cofactor), member 1 0.51 0.44 0.37 0.19 0 1 0 0 0 -1 0 0 0 0 0 1 207316_at HAS1 hyaluronan synthase 1 -0.33 -0.42 -0.45 -0.68 0 1 0 0 0 -1 0 0 0 0 0 1 209277_at TFPI2 tissue factor pathway inhibitor 2 0.37 0.56 0.03 0.31 1 1 0 1 -1 0 0 0 1 0 0 0 214681_at GK glycerol kinase -0.98 -1.15 -1.43 -1.40 0 1 1 0 0 0 1 0 0 0 0 1 215761_at DMXL2 Dmx-like 2 -0.89 -1.19 -1.38 -1.44 1 1 1 0 0 0 1 0 0 1 0 1 223454_at CXCL16 chemokine (C-X-C motif) ligand 16 -1.00 -1.26 -1.37 -1.51 0 1 1 0 0 0 1 0 0 0 0 1 224358_s_at MS4A7 membrane-spanning 4-domains, subfamily A, member 7 -1.25 -1.56 -1.77 -1.80 0 1 1 0 0 0 1 0 0 0 0 1 225283_at ARRDC4 arrestin domain containing 4 -1.43 -1.40 -1.85 -1.65 1 1 0 0 -1 0 1 0 1 0 0 0 239519_at NRP1 neuropilin 1 -1.82 -1.87 -2.38 -2.12 1 1 0 0 -1 0 1 0 1 0 0 1 242037_at asph aspartate beta-hydroxylase -1.08 -1.04 -1.47 -1.29 1 1 0 0 -1 0 1 0 1 0 0 0 202381_at ADAM9 ADAM metallopeptidase domain 9 -1.65 -1.69 -2.11 -1.93 0 1 0 0 -1 0 1 0 0 0 0 1 205098_at CCR1 chemokine (C-C motif) receptor 1 -2.46 -2.70 -2.97 -2.94 0 1 1 0 0 0 0 0 0 0 0 1 205119_s_at FPR1 formyl peptide receptor 1 -1.13 -1.48 -1.46 -1.72 1 1 1 0 0 -1 0 0 0 1 1 1 205237_at FCN1 ficolin (collagen/fibrinogen domain containing) 1 -0.85 -1.01 -1.04 -1.25 0 1 0 0 0 -1 0 0 0 0 0 1 209135_at ASPH aspartate beta-hydroxylase -1.06 -1.00 -1.53 -1.24 1 1 0 0 -1 0 1 0 1 0 1 0 211135_x_at LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and-0.64 ITIM domains),-0.75 member-0.79 -0.993 0 1 0 0 0 -1 0 0 0 0 0 1 216370_s_at TKTL1 transketolase-like 1 -1.62 -1.93 -1.88 -2.17 1 1 1 0 0 -1 0 0 0 1 1 1 217996_at PHLDA1 pleckstrin homology-like domain, family A, member 1 -1.27 -1.45 -1.74 -1.69 0 1 1 0 0 0 1 0 0 0 0 1 227080_at ZNF697 zinc finger protein 697 -1.45 -1.45 -1.89 -1.69 1 1 0 0 -1 0 1 0 1 0 0 0 240652_at ------0.93 -0.91 -0.85 -1.15 0 1 0 0 0 -1 0 0 0 0 1 0 1553313_s_at SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member-0.08 3 0.44 -0.01 0.20 1 1 0 1 0 0 0 0 0 1 0 0 201325_s_at EMP1 epithelial membrane protein 1 -1.75 -1.67 -2.13 -1.90 1 1 0 0 -1 0 1 0 1 0 0 0 202436_s_at CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -2.04 -1.96 -2.55 -2.19 1 1 0 0 -1 0 0 0 1 0 0 0 204014_at DUSP4 dual specificity phosphatase 4 -0.77 -1.09 -1.05 -1.32 1 1 1 0 0 -1 0 0 0 1 1 1 207697_x_at LILRB2 leukocyte immunoglobulin-like receptor, subfamily B (with TM and-0.90 ITIM domains),-1.14 member-1.18 -1.372 0 1 1 0 0 -1 0 0 0 0 0 1 228188_at FOSL2 FOS-like antigen 2 -0.67 -0.89 -0.97 -1.13 0 1 1 0 0 0 1 0 0 0 0 1 1554442_at BEST1 bestrophin 1 -0.31 -0.37 -0.40 -0.59 0 1 0 0 0 -1 0 0 0 0 0 1 1558691_a_at DOCK4 dedicator of cytokinesis 4 -1.34 -1.41 -1.34 -1.63 0 1 0 0 0 -1 0 0 0 0 1 1 201360_at CST3 cystatin C -0.80 -0.94 -0.89 -1.16 0 1 0 0 0 -1 0 0 0 0 1 1 207038_at SLC16A6 solute carrier family 16, member 6 (monocarboxylic acid transporter-1.63 7) -1.86 -2.03 -2.08 0 1 1 0 0 0 0 0 0 0 0 1 210225_x_at LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and-0.68 ITIM domains),-0.79 member-0.76 -1.013 0 1 0 0 0 -1 0 0 0 0 0 1 211653_x_at AKR1C2 aldo-keto reductase family 1, member C2 (dihydrodiol dehydrogenase-0.37 2; bile-0.23 acid binding-0.63 protein;-0.44 3-alpha1 hydroxysteroid1 dehydrogenase,0 0 type III)-1 0 0 0 1 0 0 0 222876_s_at ADAP2 ArfGAP with dual PH domains 2 -0.44 -0.56 -0.58 -0.78 0 1 0 0 0 -1 0 0 0 0 0 1 225955_at METRNL meteorin, glial cell differentiation regulator-like -0.19 -0.48 -0.48 -0.70 1 1 1 0 0 -1 1 0 0 1 0 1 206028_s_at MERTK c-mer proto-oncogene tyrosine kinase -1.58 -1.71 -1.73 -1.92 0 1 0 0 0 -1 0 0 0 0 0 1 215049_x_at CD163 CD163 molecule -0.57 -0.76 -1.04 -0.97 0 1 1 0 0 0 0 0 0 0 0 1 217507_at SLC11A1 solute carrier family 11 (proton-coupled divalent metal ion transporters),-2.83 member-3.00 1-3.08 -3.21 0 1 1 0 0 0 0 0 0 0 0 1 241866_at SLC16A7 solute carrier family 16, member 7 (monocarboxylic acid transporter-0.42 2) 0.08 -0.02 -0.12 1 1 -1 0 0 0 1 0 0 1 0 1 241894_at VMO1 vitelline membrane outer layer 1 homolog (chicken) -0.43 -0.52 -0.54 -0.72 0 1 0 0 0 -1 0 0 0 0 0 1 1553142_at C13orf31 chromosome 13 open reading frame 31 -1.02 -1.20 -1.41 -1.40 0 1 1 0 0 0 0 0 0 0 0 1 201324_at EMP1 epithelial membrane protein 1 -1.77 -1.68 -2.16 -1.88 1 1 0 0 -1 0 1 0 1 0 1 0 201490_s_at PPIF peptidylprolyl isomerase F -1.12 -1.42 -1.54 -1.61 0 1 1 0 0 0 1 0 0 0 0 1 201785_at RNASE1 ribonuclease, RNase A family, 1 (pancreatic) -1.73 -1.84 -1.85 -2.04 0 1 0 0 0 -1 0 0 0 0 0 1 204858_s_at TYMP thymidine phosphorylase -0.83 -1.06 -1.09 -1.27 0 1 1 0 0 -1 0 0 0 0 0 1 209699_x_at AKR1C2 aldo-keto reductase family 1, member C2 (dihydrodiol dehydrogenase-0.36 2; bile-0.18 acid binding-0.65 protein;-0.38 3-alpha1 hydroxysteroid1 dehydrogenase,0 1 type III)-1 0 0 0 1 0 1 0 209933_s_at CD300A CD300a molecule -0.07 -0.15 -0.16 -0.35 0 1 0 0 0 -1 0 0 0 0 0 1 210422_x_at SLC11A1 solute carrier family 11 (proton-coupled divalent metal ion transporters),-1.20 member-1.30 1-1.29 -1.50 0 1 0 0 0 -1 0 0 0 0 0 1 210784_x_at LILRA6 /// LILRB3leukocyte immunoglobulin-like receptor, subfamily A (with TM domain),-0.64 member-0.75 6 -0.75/// leukocyte-0.95 immunoglobulin-like0 1 receptor,0 subfamily0 B (with0 TM and ITIM-1 domains),0 member0 3 0 0 0 1 217853_at TNS3 tensin 3 -2.62 -2.58 -3.07 -2.79 1 1 0 0 -1 0 1 0 1 0 0 0 218856_at TNFRSF21 tumor necrosis factor receptor superfamily, member 21 -3.03 -3.26 -3.30 -3.46 0 1 1 0 0 0 0 0 0 0 0 1 222692_s_at FNDC3B fibronectin type III domain containing 3B -1.69 -1.43 -1.75 -1.62 1 1 0 1 0 0 0 0 1 1 0 0 235518_at SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1 -1.99 -2.23 -2.32 -2.44 0 1 1 0 0 0 1 0 0 0 0 1 238831_at TMEM33 transmembrane protein 33 -0.67 -0.27 -0.55 -0.48 1 1 0 1 0 0 0 0 0 1 0 0 1556202_at SRGAP2 SLIT-ROBO Rho GTPase activating protein 2 -0.74 -0.37 -0.52 -0.56 1 1 -1 0 0 0 0 0 0 1 0 0 210896_s_at ASPH aspartate beta-hydroxylase -1.23 -1.25 -1.71 -1.44 1 1 0 0 -1 0 1 0 1 0 0 0 211067_s_at GAS7 growth arrest-specific 7 -0.26 -0.46 -0.62 -0.65 0 1 1 0 0 0 1 0 0 0 0 1

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211336_x_at LILRB1 leukocyte immunoglobulin-like receptor, subfamily B (with TM and-0.99 ITIM domains),-1.15 member-1.14 -1.341 0 1 0 0 0 -1 0 0 0 0 0 1 212944_at SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member0.12 3 0.54 -0.07 0.35 1 1 0 1 -1 0 0 0 1 1 1 0 213472_at HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.32 0.10 0.13 -0.09 1 1 -1 0 0 0 1 0 0 1 0 0 214560_at FPR3 formyl peptide receptor 3 -2.75 -2.77 -2.68 -2.96 0 1 0 0 0 -1 0 0 0 0 1 0 216594_x_at AKR1C1 aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase-0.30 1; 20-alpha-0.19 (3-alpha)-hydroxysteroid-0.62 -0.38 1 dehydrogenase)1 0 0 -1 0 1 0 1 0 0 0 224996_at ASPH aspartate beta-hydroxylase -0.92 -0.84 -1.38 -1.03 1 1 0 0 -1 0 1 0 1 0 1 0 228573_at ANTXR2 anthrax toxin receptor 2 -0.33 -0.16 -0.48 -0.35 1 1 0 1 0 0 0 0 1 0 0 0 229900_at CD109 CD109 molecule -1.34 -1.16 -1.50 -1.36 1 1 0 1 0 0 0 0 1 0 0 0 204011_at SPRY2 sprouty homolog 2 (Drosophila) -2.56 -2.32 -2.87 -2.50 1 1 0 1 -1 0 0 0 1 0 1 0 208198_x_at KIR2DS1 killer cell immunoglobulin-like receptor, two domains, short cytoplasmic0.30 tail,0.22 1 0.24 0.04 0 1 0 0 0 -1 0 0 0 0 0 1 211242_x_at KIR2DL4 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic0.19 tail,0.08 4 0.15 -0.10 0 1 0 0 0 -1 0 0 0 0 0 1 211688_x_at KIR3DL1 /// KIR3DL2killer cell /// immunoglobulin-likeLOC727787 receptor, three domains, long cytoplasmic0.55 tail,0.44 1 /// killer0.44 cell immunoglobulin-like0.26 0 receptor,1 three0 domains,0 long cytoplasmic0 -1 tail, 2 /// killer0 cell immunoglobulin-like0 0 receptor,0 three0 domains,1 long cytoplasmic tail, 2-like 222693_at FNDC3B fibronectin type III domain containing 3B -1.86 -1.57 -1.84 -1.75 1 1 0 1 0 0 0 0 0 1 0 0 226364_at HIP1 huntingtin interacting protein 1 -1.44 -1.48 -1.87 -1.66 1 1 0 0 -1 0 1 0 1 0 0 0 226545_at CD109 CD109 molecule -2.08 -1.94 -2.32 -2.12 1 1 0 0 -1 0 0 0 1 0 0 0 242871_at PAQR5 progestin and adipoQ receptor family member V -1.77 -1.67 -2.06 -1.85 1 1 0 0 -1 0 0 0 1 0 0 0 1569773_at ATP8A1 ATPase, aminophospholipid transporter (APLT), class I, type 8A, member-0.36 1 0.13 0.28 -0.05 1 1 -1 0 0 0 1 0 0 1 1 1 224414_s_at CARD6 caspase recruitment domain family, member 6 -0.97 -0.80 -1.23 -0.97 1 1 0 0 -1 0 0 0 1 0 0 0 237588_at SMCHD1 structural maintenance of chromosomes flexible hinge domain containing-0.16 10.27 0.24 0.10 1 1 -1 0 0 0 1 0 0 1 0 0 242732_at NDUFB9 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 9, 22kDa -0.33 0.10 -0.10 -0.07 1 1 -1 1 0 0 0 0 0 1 0 0 210152_at LILRB4 leukocyte immunoglobulin-like receptor, subfamily B (with TM and-2.20 ITIM domains),-2.38 member-2.38 -2.544 0 1 1 0 0 0 0 0 0 0 0 1 211192_s_at CD84 CD84 molecule -0.98 -0.62 -0.68 -0.78 1 1 -1 0 0 0 1 0 0 1 0 0 221060_s_at TLR4 toll-like receptor 4 -0.59 -0.78 -0.87 -0.94 0 1 1 0 0 0 0 0 0 0 0 1 205966_at TAF13 TAF13 RNA polymerase II, TATA box binding protein (TBP)-associated-1.41 factor,-0.96 18kDa -0.99 -1.11 1 1 -1 0 0 0 1 0 0 1 0 1 212157_at SDC2 syndecan 2 -1.73 -2.08 -2.16 -2.24 1 1 1 0 0 0 1 0 0 1 0 1 230323_s_at TMEM45B transmembrane protein 45B -0.89 -1.09 -1.26 -1.24 0 1 1 0 0 0 0 0 0 0 0 1 230422_at FPR3 formyl peptide receptor 3 -3.29 -3.61 -3.61 -3.76 0 1 1 0 0 0 0 0 0 0 0 1 232653_at TRPS1 trichorhinophalangeal syndrome I -0.97 -1.14 -1.32 -1.29 0 1 1 0 0 0 1 0 0 0 0 1 235180_at STYX serine/threonine/tyrosine interacting protein -0.56 -0.24 -0.21 -0.39 1 1 -1 0 0 0 1 0 0 1 0 0 242408_at STYX serine/threonine/tyrosine interacting protein -0.64 -0.23 -0.22 -0.37 1 1 -1 0 0 0 1 0 0 1 0 1 243299_at VRK2 Vaccinia related kinase 2 -1.14 -1.34 -1.40 -1.48 0 1 1 0 0 0 0 0 0 0 0 1 1554503_a_at OSCAR osteoclast associated, immunoglobulin-like receptor -0.80 -1.00 -1.03 -1.14 0 1 1 0 0 0 0 0 0 0 0 1 203889_at SCG5 secretogranin V (7B2 protein) -2.99 -3.12 -3.61 -3.26 1 1 0 0 -1 0 1 0 1 0 0 0 204088_at P2RX4 purinergic receptor P2X, ligand-gated ion channel, 4 -0.55 -0.74 -0.81 -0.87 0 1 1 0 0 0 0 0 0 0 0 1 1552703_s_at CARD16 /// CASP1caspase recruitment domain family, member 16 /// caspase 1, apoptosis-related0.70 0.52 cysteine0.44 peptidase0.39 (interleukin0 1, beta,1 convertase)1 0 0 0 0 0 0 0 0 1 214041_x_at RPL37A Ribosomal protein L37a -0.18 0.19 0.20 0.06 1 1 -1 0 0 0 1 0 0 1 0 0 230127_at ------1.02 -0.89 -1.35 -1.02 1 1 0 0 -1 0 0 0 1 0 1 0 227314_at ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.87 -0.69 -1.06 -0.82 1 1 0 0 -1 0 0 0 1 0 0 0 229706_at tcerg1 transcription elongation regulator 1 -0.18 0.40 0.44 0.28 1 1 -1 0 0 0 1 0 0 1 0 1 239819_at ------0.28 0.12 0.12 0.01 1 1 -1 0 0 0 1 0 0 1 0 1 207545_s_at NUMB numb homolog (Drosophila) -1.20 -1.07 -1.44 -1.19 1 1 0 0 -1 0 0 0 1 0 0 0 214149_s_at ATP6V0E1 ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1 -0.79 -0.45 -0.48 -0.56 1 1 -1 0 0 0 0 0 0 1 0 0 227195_at ZNF503 zinc finger protein 503 -1.18 -1.41 -1.37 -1.52 0 1 1 0 0 0 0 0 0 0 0 1 237318_at Slc43a2 solute carrier family 43, member 2 -1.45 -1.63 -1.73 -1.74 0 1 1 0 0 0 1 0 0 0 0 1 240498_at ETV6 ets variant 6 -1.00 -0.69 -0.79 -0.80 1 1 -1 0 0 0 0 0 0 1 0 0 240544_at ZFAND3 zinc finger, AN1-type domain 3 -0.61 -0.29 -0.43 -0.40 1 1 -1 0 0 0 0 0 0 1 0 0 1553252_a_at BRWD3 bromodomain and WD repeat domain containing 3 -0.50 -0.22 -0.18 -0.32 1 1 -1 0 0 0 1 0 0 1 0 0 1565598_at RBM47 RNA binding motif protein 47 -1.72 -1.73 -2.07 -1.82 1 1 0 0 -1 0 1 0 1 0 0 0 220253_s_at LRP12 low density lipoprotein receptor-related protein 12 -2.26 -1.94 -2.07 -2.04 1 1 -1 0 0 0 0 0 0 1 0 0 224311_s_at CAB39 calcium binding protein 39 -0.43 -0.12 0.00 -0.22 1 1 -1 0 0 0 1 0 0 1 0 0 244840_x_at DOCK4 dedicator of cytokinesis 4 -1.16 -1.51 -1.61 -1.61 1 1 1 0 0 0 1 0 0 1 0 1 202195_s_at TMED5 transmembrane emp24 protein transport domain containing 5 -1.07 -1.01 -1.27 -1.10 1 1 0 0 -1 0 0 0 1 0 0 0 225188_at RAPH1 Ras association (RalGDS/AF-6) and pleckstrin homology domains 1-1.64 -1.70 -2.01 -1.79 0 1 0 0 -1 0 1 0 0 0 0 0 231644_at ------1.36 -1.60 -1.56 -1.69 0 1 1 0 0 0 0 0 0 0 0 1 1555977_at LOC727918 hypothetical LOC727918 0.18 0.08 0.43 0.00 1 1 0 0 1 0 0 0 1 0 1 0 1570021_at LOC360030 homeobox C14 -1.05 -0.64 -0.87 -0.72 1 1 -1 0 0 0 0 0 0 1 0 1 202600_s_at NRIP1 nuclear receptor interacting protein 1 -0.99 -0.70 -0.71 -0.78 1 1 -1 0 0 0 1 0 0 1 0 0 218273_s_at PDP1 pyruvate dehyrogenase phosphatase catalytic subunit 1 -0.41 -0.09 -0.04 -0.17 1 1 -1 0 0 0 1 0 0 1 0 0 222679_s_at DCUN1D1 DCN1, defective in cullin neddylation 1, domain containing 1 (S. cerevisiae)-0.67 -0.31 -0.38 -0.38 1 1 -1 0 0 0 1 0 0 1 0 1 222880_at AKT3 v-akt murine thymoma viral oncogene homolog 3 (protein kinase B,-0.67 gamma)-0.33 -0.33 -0.41 1 1 -1 0 0 0 1 0 0 1 0 0 235451_at SMAD5 SMAD family member 5 -0.67 -0.33 -0.42 -0.41 1 1 -1 0 0 0 0 0 0 1 0 0 236327_at CEPT1 choline/ethanolamine phosphotransferase 1 -0.47 -0.16 -0.29 -0.24 1 1 -1 0 0 0 0 0 0 1 0 0 241345_at MIR186 /// ZRANB2microRNA 186 /// zinc finger, RAN-binding domain containing 2 -0.49 -0.10 -0.12 -0.18 1 1 -1 0 0 0 1 0 0 1 0 1 202601_s_at HTATSF1 HIV-1 Tat specific factor 1 -0.18 -0.10 0.10 -0.17 0 1 0 0 1 0 1 0 0 0 1 0 217513_at C17orf60 chromosome 17 open reading frame 60 -1.03 -1.25 -1.28 -1.32 0 1 1 0 0 0 0 0 0 0 0 1 217576_x_at SOS2 son of sevenless homolog 2 (Drosophila) -0.22 0.03 0.11 -0.04 0 1 -1 0 0 0 1 0 0 0 0 0 227948_at FGD4 FYVE, RhoGEF and PH domain containing 4 -1.17 -1.37 -1.45 -1.45 0 1 1 0 0 0 1 0 0 0 0 1 228181_at SLC30A1 solute carrier family 30 (zinc transporter), member 1 0.03 0.15 -0.15 0.08 1 1 0 0 -1 0 0 0 1 0 0 0 238644_at MYSM1 Myb-like, SWIRM and MPN domains 1 -0.43 -0.28 -0.08 -0.35 0 1 0 0 1 0 1 0 0 0 1 0 238848_at OTUD4 OTU domain containing 4 -0.60 -0.28 -0.22 -0.35 1 1 -1 0 0 0 1 0 0 1 0 0 1552553_a_at NLRC4 NLR family, CARD domain containing 4 -1.27 -1.58 -1.56 -1.64 1 1 1 0 0 0 0 0 0 1 0 1 1553575_at ND6 NADH dehydrogenase, subunit 6 (complex I) 1.28 1.01 1.09 0.94 0 1 1 0 0 0 0 0 0 0 0 1 1563445_x_at CTSL1P8 cathepsin L1 pseudogene 8 -1.69 -1.88 -1.92 -1.95 0 1 1 0 0 0 0 0 0 0 0 1 201299_s_at MOBKL1B MOB1, Mps One Binder kinase activator-like 1B (yeast) -0.56 -0.21 -0.20 -0.27 1 1 -1 0 0 0 1 0 0 1 0 1 202869_at OAS1 2',5'-oligoadenylate synthetase 1, 40/46kDa -0.12 -0.33 -0.30 -0.39 0 1 1 0 0 0 0 0 0 0 0 1 210282_at ZMYM2 zinc finger, MYM-type 2 -0.41 -0.01 -0.19 -0.07 1 1 -1 0 0 0 0 0 0 1 0 1 210873_x_at APOBEC3A apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like -0.413A -0.65 -0.60 -0.71 0 1 1 0 0 0 0 0 0 0 0 1 213956_at CEP350 centrosomal protein 350kDa -0.26 0.10 0.07 0.04 1 1 -1 0 0 0 1 0 0 1 0 1 214483_s_at ARFIP1 ADP-ribosylation factor interacting protein 1 -0.85 -0.57 -0.52 -0.63 1 1 -1 0 0 0 1 0 0 1 0 0 218854_at DSE dermatan sulfate epimerase -1.54 -1.51 -1.78 -1.57 1 1 0 0 -1 0 0 0 1 0 0 0 219844_at C10orf118 chromosome 10 open reading frame 118 -0.40 -0.07 -0.09 -0.13 1 1 -1 0 0 0 1 0 0 1 0 1 230742_at RBM6 RNA binding motif protein 6 -0.11 0.16 0.20 0.10 1 1 -1 0 0 0 1 0 0 1 0 0 244579_at TRPS1 trichorhinophalangeal syndrome I -0.98 -1.19 -1.33 -1.25 0 1 1 0 0 0 1 0 0 0 0 1 1555730_a_at CFL1 cofilin 1 (non-muscle) -0.37 -0.51 -0.15 -0.56 1 1 0 0 1 0 0 0 1 0 1 0 1563431_x_at CALM3 Calmodulin 3 (phosphorylase kinase, delta) -0.21 0.13 -0.02 0.08 1 1 -1 0 0 0 0 0 0 1 0 1 204628_s_at ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) -0.23 0.04 -0.04 -0.01 1 1 -1 0 0 0 0 0 0 1 0 0 220220_at LRRC37A4 leucine rich repeat containing 37, member A4 (pseudogene) -0.23 0.16 0.12 0.11 1 1 -1 0 0 0 1 0 0 1 0 1 224618_at ROD1 ROD1 regulator of differentiation 1 (S. pombe) -0.44 -0.14 -0.22 -0.18 1 1 -1 0 0 0 0 0 0 1 0 0 1556812_a_at ANKRD44 ankyrin repeat domain 44 -0.20 -0.05 0.20 -0.09 0 1 0 0 1 0 1 0 0 0 1 0 1559954_s_at DDX42 DEAD (Asp-Glu-Ala-Asp) box polypeptide 42 -0.60 -0.26 -0.15 -0.30 1 1 -1 0 0 0 1 0 0 1 0 1 202430_s_at PLSCR1 phospholipid scramblase 1 -1.12 -1.36 -1.31 -1.40 0 1 1 0 0 0 0 0 0 0 0 1 212720_at PAPOLA poly(A) polymerase alpha -0.89 -0.61 -0.56 -0.65 1 1 -1 0 0 0 1 0 0 1 0 0 226184_at FMNL2 formin-like 2 -0.86 -0.88 -1.21 -0.92 0 1 0 0 -1 0 0 0 0 0 1 0 227259_at CD47 CD47 molecule -0.20 0.15 0.08 0.11 1 1 -1 0 0 0 1 0 0 1 0 1 241207_at mkl1 megakaryoblastic leukemia (translocation) 1 -0.71 -0.33 -0.32 -0.37 1 1 -1 0 0 0 1 0 0 1 0 1 242248_at PHKB phosphorylase kinase, beta -0.21 0.05 0.10 0.02 0 1 -1 0 0 0 1 0 0 0 0 0 244774_at PHACTR2 phosphatase and actin regulator 2 -0.94 -0.54 -0.58 -0.58 1 1 -1 0 0 0 0 0 0 1 0 1 33148_at ZFR zinc finger RNA binding protein -0.82 -0.40 -0.41 -0.44 1 1 -1 0 0 0 1 0 0 1 0 1 1552978_a_at SCAMP1 secretory carrier membrane protein 1 -0.52 -0.29 -0.10 -0.32 0 1 -1 0 1 0 1 0 0 0 0 0 1557626_at ------0.83 -0.86 -1.12 -0.89 0 1 0 0 -1 0 1 0 0 0 0 0 202241_at TRIB1 tribbles homolog 1 (Drosophila) -1.17 -1.15 -1.43 -1.18 1 1 0 0 -1 0 1 0 1 0 0 0 209013_x_at TRIO triple functional domain (PTPRF interacting) -1.38 -1.06 -1.17 -1.08 1 1 -1 0 0 0 0 0 0 1 0 1 211973_at LOC100507620hypothetical LOC100507620 -0.80 -0.32 -0.57 -0.35 1 1 -1 0 0 0 0 0 0 1 0 1 215767_at ZNF804A zinc finger protein 804A -1.37 -1.31 -1.59 -1.33 1 1 0 0 -1 0 0 0 1 0 0 0 229841_at EIF2C2 eukaryotic translation initiation factor 2C, 2 -0.32 -0.04 -0.14 -0.07 1 1 -1 0 0 0 0 0 0 1 0 0 230265_at SEL1L Sel-1 suppressor of lin-12-like (C. elegans) -0.86 -0.55 -0.69 -0.58 1 1 -1 0 0 0 0 0 0 1 0 1 238220_at KDM6A lysine (K)-specific demethylase 6A -0.57 -0.24 -0.34 -0.26 1 1 -1 0 0 0 0 0 0 1 0 1 1555594_a_at MBNL1 muscleblind-like (Drosophila) -0.36 -0.03 0.04 -0.05 1 1 -1 0 0 0 1 0 0 1 0 1 1569583_at EREG epiregulin -0.66 -1.11 -1.32 -1.14 1 1 1 0 -1 0 1 0 0 1 0 1

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200671_s_at SPTBN1 spectrin, beta, non-erythrocytic 1 -0.29 -0.05 0.04 -0.08 0 1 -1 0 0 0 1 0 0 0 0 0 203231_s_at ATXN1 ataxin 1 -0.84 -0.53 -0.57 -0.55 1 1 -1 0 0 0 1 0 0 1 0 1 208178_x_at TRIO triple functional domain (PTPRF interacting) -1.33 -0.98 -1.08 -1.00 1 1 -1 0 0 0 0 0 0 1 0 1 209599_s_at PRUNE prune homolog (Drosophila) -0.15 0.07 0.11 0.05 0 1 -1 0 0 0 1 0 0 0 0 0 212105_s_at DHX9 DEAH (Asp-Glu-Ala-His) box polypeptide 9 -0.92 -0.56 -0.49 -0.57 1 1 -1 0 0 0 1 0 0 1 0 1 214834_at PAR5 Prader-Willi/Angelman syndrome-5 -0.29 -0.01 0.06 -0.03 1 1 -1 0 0 0 1 0 0 1 0 0 236023_at CDK9 cyclin-dependent kinase 9 -0.83 -0.49 -0.62 -0.51 1 1 -1 0 0 0 0 0 0 1 0 1 236723_at Hnrnpu heterogeneous nuclear ribonucleoprotein U (scaffold attachment -0.58factor A)-0.24 -0.20 -0.26 1 1 -1 0 0 0 1 0 0 1 0 1 240636_at C11orf61 chromosome 11 open reading frame 61 -0.31 -0.07 0.02 -0.09 0 1 -1 0 0 0 1 0 0 0 0 0 240957_at Vps26a vacuolar protein sorting 26 homolog A (S. pombe) -0.80 -0.51 -0.51 -0.53 1 1 -1 0 0 0 1 0 0 1 0 1 200928_s_at RAB14 RAB14, member RAS oncogene family -0.40 -0.04 -0.14 -0.05 1 1 -1 0 0 0 1 0 0 1 0 1 224595_at SLC44A1 solute carrier family 44, member 1 -1.13 -1.28 -1.51 -1.29 0 1 0 0 -1 0 1 0 0 0 0 0 227152_at C12orf35 chromosome 12 open reading frame 35 -0.14 0.18 0.27 0.16 1 1 -1 0 0 0 1 0 0 1 0 1 235011_at MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.94 -0.64 -0.72 -0.66 1 1 -1 0 0 0 0 0 0 1 0 1 237118_at ANP32A /// LOC723972hepatopoietin PCn127; acidic (leucine-rich) nuclear phosphoprotein-0.52 32 family,-0.17 member-0.18 A -0.18 1 1 -1 0 0 0 1 0 0 1 0 1 237554_at ------0.86 -0.46 -0.61 -0.47 1 1 -1 0 0 0 0 0 0 1 0 1 239871_at CLTC Clathrin, heavy chain (Hc) -0.54 -0.32 -0.22 -0.33 0 1 -1 0 0 0 1 0 0 0 0 0 224875_at C5orf24 chromosome 5 open reading frame 24 -0.35 -0.01 -0.04 -0.02 1 1 -1 0 0 0 0 0 0 1 0 1 238884_at CTNND1 catenin (cadherin-associated protein), delta 1 -0.89 -0.59 -0.59 -0.59 1 1 -1 0 0 0 1 0 0 1 0 1 239742_at TULP4 Tubby like protein 4 -0.39 -0.11 -0.10 -0.11 1 1 -1 0 0 0 1 0 0 1 0 1 241155_at PIP4K2A phosphatidylinositol-5-phosphate 4-kinase, type II, alpha -0.29 -0.03 -0.09 -0.03 1 1 -1 0 0 0 0 0 0 1 0 1 60815_at POLR2J4 polymerase (RNA) II (DNA directed) polypeptide J4, pseudogene -0.48 -0.25 -0.19 -0.26 0 1 -1 0 0 0 1 0 0 0 0 0 1556336_at RBMX RNA binding motif protein, X-linked -0.37 -0.10 0.03 -0.09 1 1 -1 0 0 0 1 0 0 1 0 1 1558747_at SMCHD1 structural maintenance of chromosomes flexible hinge domain containing-0.19 1-0.22 0.38 -0.21 1 1 0 0 1 0 1 0 1 0 1 0 1562527_at LOC283027 hypothetical protein LOC283027 0.81 0.62 1.05 0.63 0 1 0 0 1 0 0 0 0 0 1 0 201073_s_at SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin,-0.27 -0.02 subfamily-0.01 c, member0.00 1 0 1 -1 0 0 0 1 0 0 0 0 1 208575_at HIST1H3A histone cluster 1, H3a -0.25 0.00 0.00 0.02 0 1 -1 0 0 0 0 0 0 0 0 1 210436_at CCT8 chaperonin containing TCP1, subunit 8 (theta) -0.34 -0.12 -0.02 -0.11 0 1 -1 0 0 0 1 0 0 0 0 0 212079_s_at MLL myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, -0.37Drosophila)-0.09 -0.01 -0.09 1 1 -1 0 0 0 1 0 0 1 0 1 221695_s_at MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.67 -0.44 -0.34 -0.43 0 1 -1 0 0 0 1 0 0 0 0 0 222508_s_at ARGLU1 arginine and glutamate rich 1 -0.10 -0.01 0.18 0.00 0 1 0 0 1 0 1 0 0 0 0 0 223984_s_at NUPL1 nucleoporin like 1 -0.82 -0.49 -0.52 -0.48 1 1 -1 0 0 0 1 0 0 1 0 1 224152_s_at PBRM1 polybromo 1 -0.76 -0.54 -0.45 -0.53 0 1 -1 0 0 0 1 0 0 0 0 0 224940_s_at PAPPA pregnancy-associated plasma protein A, pappalysin 1 0.36 0.27 0.54 0.28 1 1 0 0 1 0 0 0 1 0 0 0 235577_at ZNF652 zinc finger protein 652 -0.50 -0.22 -0.25 -0.21 1 1 -1 0 0 0 0 0 0 1 0 1 237625_s_at ------0.06 0.15 0.22 0.16 0 1 -1 0 0 0 1 0 0 0 0 0 240613_at JAK1 Janus kinase 1 -0.68 -0.29 -0.42 -0.28 1 1 -1 0 0 0 0 0 0 1 0 1 242429_at ZNF567 zinc finger protein 567 -0.45 -0.20 -0.08 -0.19 0 1 -1 0 0 0 1 0 0 0 0 0 243064_at mtif3 mitochondrial translational initiation factor 3 -0.21 0.03 0.07 0.04 0 1 -1 0 0 0 1 0 0 0 0 0 213638_at PHACTR1 phosphatase and actin regulator 1 -1.46 -1.07 -1.13 -1.06 1 1 -1 0 0 0 0 0 0 1 0 1 214352_s_at KRAS v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog -0.33 -0.08 0.00 -0.06 0 1 -1 0 0 0 1 0 0 0 0 1 215284_at SNX9 sorting nexin 9 -0.47 -0.20 -0.28 -0.18 1 1 -1 0 0 0 0 0 0 1 0 1 218430_s_at RFX7 regulatory factor X, 7 -0.33 0.04 0.13 0.05 1 1 -1 0 0 0 1 0 0 1 0 1 235743_at SNED1 sushi, nidogen and EGF-like domains 1 -0.35 -0.06 0.11 -0.05 1 1 -1 0 0 0 1 0 0 1 0 1 237813_at PCBP2 poly(rC) binding protein 2 -0.40 -0.16 -0.01 -0.14 0 1 -1 0 0 0 1 0 0 0 0 1 240246_at LOC642236 Similar to FRG1 protein (FSHD region gene 1 protein) -0.57 -0.21 -0.24 -0.19 1 1 -1 0 0 0 1 0 0 1 0 1 241347_at RNF213 ring finger protein 213 0.04 0.31 0.45 0.33 1 1 -1 0 0 0 1 0 0 1 0 1 241955_at HECTD1 HECT domain containing 1 -0.59 -0.33 -0.19 -0.31 0 1 -1 0 0 0 1 0 0 0 0 1 1557278_s_at TNPO1 Transportin 1 -0.45 -0.01 -0.09 0.02 1 1 -1 0 0 0 1 0 0 1 0 1 204863_s_at IL6ST interleukin 6 signal transducer (gp130, oncostatin M receptor) -0.30 0.03 0.00 0.06 1 1 -1 0 0 0 1 0 0 1 0 1 211947_s_at BAT2L2 HLA-B associated transcript 2-like 2 -0.30 -0.03 0.11 0.01 1 1 -1 0 0 0 1 0 0 1 0 1 213971_s_at LOC100510525polycomb /// SUZ12 protein /// SUZ12P SUZ12-like /// suppressor of zeste 12 homolog (Drosophila)-0.47 -0.20 /// suppressor-0.18 -0.17 of zeste 12 homolog0 pseudogene1 -1 0 0 0 1 0 0 0 0 1 214806_at BICD1 bicaudal D homolog 1 (Drosophila) -0.19 -0.02 0.10 0.01 0 1 -1 0 0 0 1 0 0 0 0 0 240165_at ------0.26 0.00 -0.11 0.03 0 1 1 0 0 0 1 0 0 0 0 0 244804_at SQSTM1 sequestosome 1 -0.16 0.07 0.15 0.10 0 1 -1 0 0 0 1 0 0 0 0 0 208930_s_at ILF3 interleukin enhancer binding factor 3, 90kDa -0.26 -0.03 0.00 0.01 0 1 -1 0 0 0 0 0 0 0 0 1 211965_at ZFP36L1 zinc finger protein 36, C3H type-like 1 -0.28 -0.11 -0.02 -0.07 0 1 -1 0 0 0 1 0 0 0 0 0 212286_at ANKRD12 ankyrin repeat domain 12 -0.32 -0.01 -0.14 0.03 1 1 -1 0 0 0 0 0 0 1 0 1 214250_at NUMA1 nuclear mitotic apparatus protein 1 -0.68 -0.26 -0.15 -0.21 1 1 -1 0 0 0 1 0 0 1 0 1 221705_s_at SIKE1 suppressor of IKBKE 1 -0.40 -0.18 -0.07 -0.14 0 1 -1 0 0 0 1 0 0 0 0 0 222406_s_at PNRC2 proline-rich nuclear receptor coactivator 2 -0.37 -0.16 -0.04 -0.12 0 1 -1 0 0 0 1 0 0 0 0 0 226975_at RNPC3 RNA-binding region (RNP1, RRM) containing 3 -0.01 0.18 0.30 0.22 0 1 -1 0 0 0 1 0 0 0 0 0 233309_at Tmem2 transmembrane protein 2 -0.07 0.17 0.16 0.21 0 1 -1 0 0 0 0 0 0 0 0 1 233543_s_at FAM175A family with sequence similarity 175, member A -0.09 0.19 0.22 0.22 1 1 -1 0 0 0 1 0 0 1 0 1 235765_at TLE4 transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila) -0.10 0.15 0.26 0.19 0 1 -1 0 0 0 1 0 0 0 0 1 237577_at PCNP PEST proteolytic signal containing nuclear protein -0.45 0.00 0.08 0.04 1 1 -1 0 0 0 1 0 0 1 0 1 238159_at ------0.54 -0.27 -0.35 -0.23 1 1 -1 0 0 0 0 0 0 1 0 1 214499_s_at BCLAF1 BCL2-associated transcription factor 1 -0.17 0.07 0.08 0.12 0 1 -1 0 0 0 0 0 0 0 0 1 230064_at ------0.28 0.01 0.13 0.06 1 1 -1 0 0 0 1 0 0 1 0 1 241947_at LOC100233209hypothetical LOC100233209 -0.06 0.17 0.18 0.22 0 1 -1 0 0 0 0 0 0 0 0 1 243107_at CCR7 chemokine (C-C motif) receptor 7 -0.27 0.01 0.28 0.07 1 1 -1 0 1 0 1 0 0 1 0 1 243319_at med31 mediator complex subunit 31 -0.48 -0.17 -0.24 -0.12 1 1 -1 0 0 0 0 0 0 1 0 1 206241_at KPNA5 karyopherin alpha 5 (importin alpha 6) -0.69 -0.44 -0.49 -0.37 0 1 -1 0 0 0 0 0 0 0 0 1 211000_s_at IL6ST interleukin 6 signal transducer (gp130, oncostatin M receptor) -0.42 -0.15 -0.15 -0.09 1 1 -1 0 0 0 0 0 0 1 0 1 211081_s_at MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 -0.77 -0.32 -0.26 -0.27 1 1 -1 0 0 0 1 0 0 1 0 1 222634_s_at TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.45 -0.27 -0.16 -0.21 0 1 -1 0 0 0 1 0 0 0 0 0 230028_at kiaa0907 KIAA0907 -0.08 0.15 0.17 0.21 0 1 -1 0 0 0 0 0 0 0 0 1 235009_at BOD1L biorientation of chromosomes in cell division 1-like -0.35 -0.08 0.27 -0.02 1 1 -1 0 1 0 1 0 1 1 1 1 236000_s_at HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA-0.27 binding-0.05 protein 1,0.06 37kDa) 0.01 0 1 -1 0 0 0 1 0 0 0 0 1 239798_at ------0.04 0.28 0.23 0.34 0 1 -1 0 0 0 0 0 0 0 0 1 243332_at GUSBP3 glucuronidase, beta pseudogene; glucuronidase, beta pseudogene 0.631 0.54 0.94 0.59 1 1 0 0 1 0 0 0 1 0 1 0 1565436_s_at MLL myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, -0.16Drosophila)0.14 0.25 0.21 1 1 -1 0 0 0 1 0 0 1 0 1 201085_s_at SON SON DNA binding protein -0.32 -0.11 -0.07 -0.04 0 1 -1 0 0 0 0 0 0 0 0 1 210251_s_at RUFY3 RUN and FYVE domain containing 3 -0.42 -0.21 -0.21 -0.14 0 1 -1 0 0 0 0 0 0 0 0 1 213430_at RUFY3 RUN and FYVE domain containing 3 -0.49 -0.14 -0.25 -0.07 1 1 -1 0 0 0 0 0 0 1 0 1 223038_s_at FAM60A family with sequence similarity 60, member A -0.02 0.20 0.35 0.27 0 1 -1 0 0 0 1 0 0 0 0 1 227632_at TBC1D24 TBC1 domain family, member 24 -0.53 -0.22 -0.29 -0.16 1 1 -1 0 0 0 0 0 0 1 0 1 236356_at NDUFS1 NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme-0.64 -0.28 Q reductase)-0.40 -0.21 1 1 -1 0 0 0 0 0 0 1 0 1 1405_i_at CCL5 chemokine (C-C motif) ligand 5 0.46 0.67 0.65 0.75 0 1 -1 0 0 0 0 0 0 0 0 1 1557529_at C12orf51 chromosome 12 open reading frame 51 -0.08 0.16 0.24 0.23 0 1 -1 0 0 0 1 0 0 0 0 1 227101_at ZNF800 zinc finger protein 800 -0.30 -0.13 0.13 -0.04 0 1 -1 0 1 0 1 0 0 0 0 0 236650_at ------0.14 0.06 0.16 0.14 0 1 -1 0 0 0 1 0 0 0 0 1 242432_at ------0.67 -0.30 -0.25 -0.22 1 1 -1 0 0 0 1 0 0 1 0 1 244125_at MGC70870 C-terminal binding protein 2 pseudogene 0.33 0.34 0.60 0.42 0 1 0 0 1 0 1 0 0 0 0 0 200607_s_at RAD21 RAD21 homolog (S. pombe) -0.07 -0.07 0.21 0.03 1 1 0 0 1 0 1 0 1 0 0 0 201065_s_at GTF2I /// GTF2IP1general /// LOC100093631 transcription factor IIi /// general transcription factor IIi, pseudogene-0.18 0.04 1 /// general0.00 transcription0.13 factor0 II, i, pseudogene1 -1 0 0 0 0 0 0 0 0 1 204192_at CD37 CD37 molecule 0.00 -0.05 0.24 0.03 1 1 0 0 1 0 0 0 1 0 0 0 205285_s_at FYB FYN binding protein 0.47 0.37 0.72 0.46 1 1 0 0 1 0 0 0 1 0 0 0 214184_at NPFF neuropeptide FF-amide peptide precursor -0.25 -0.24 -0.44 -0.16 0 1 0 0 -1 0 0 0 0 0 1 0 219864_s_at RCAN3 RCAN family member 3 -0.54 -0.35 -0.22 -0.26 0 1 -1 0 0 0 1 0 0 0 0 1 229437_at MIR155HG MIR155 host gene (non-protein coding) 0.85 1.10 1.02 1.20 0 1 -1 0 0 0 0 0 0 0 0 1 219969_at TXLNG taxilin gamma -0.45 -0.26 -0.16 -0.15 0 1 -1 0 0 0 1 0 0 0 0 1 230000_at RNF213 ring finger protein 213 -0.16 0.09 0.11 0.19 0 1 -1 0 0 0 1 0 0 0 0 1 236971_at clu clusterin -0.36 -0.11 -0.09 -0.02 0 1 -1 0 0 0 1 0 0 0 0 1 242774_at SYNE2 spectrin repeat containing, nuclear envelope 2 -0.20 -0.12 0.29 -0.01 1 1 0 0 1 0 1 0 1 0 1 0 212979_s_at FAM115A family with sequence similarity 115, member A -0.09 0.14 0.08 0.25 0 1 -1 0 0 0 0 0 0 0 0 1 217546_at MT1M metallothionein 1M 2.03 2.17 1.81 2.29 0 1 0 0 -1 0 0 0 0 0 1 0 235643_at SAMD9L sterile alpha motif domain containing 9-like 0.30 0.16 0.58 0.27 1 1 0 0 1 0 0 0 1 0 1 0 239487_at FAM98A Family with sequence similarity 98, member A -0.18 -0.01 0.07 0.10 0 1 -1 0 0 0 0 0 0 0 0 1

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240990_at rab5a RAB5A, member RAS oncogene family -0.68 -0.39 -0.39 -0.28 1 1 -1 0 0 0 1 0 0 1 0 1 244794_at ------0.46 -0.27 -0.26 -0.16 0 1 -1 0 0 0 0 0 0 0 0 1 1564430_at Bat2l2 BAT2 domain containing 1 -0.66 -0.36 -0.48 -0.23 1 1 -1 0 0 0 0 0 0 1 0 1 211538_s_at HSPA2 heat shock 70kDa protein 2 -0.53 -0.27 -0.35 -0.15 0 1 -1 0 0 0 0 0 0 0 0 1 222538_s_at APPL1 adaptor protein, phosphotyrosine interaction, PH domain and leucine-0.23 zipper-0.04 containing0.04 1 0.08 0 1 -1 0 0 0 1 0 0 0 0 1 241508_at ANKRD12 ankyrin repeat domain 12 -0.26 0.04 0.00 0.16 1 1 -1 0 0 0 0 0 0 1 0 1 204560_at FKBP5 FK506 binding protein 5 -0.09 0.11 0.15 0.25 0 1 -1 0 0 0 0 0 0 0 0 1 218404_at SNX10 sorting nexin 10 -1.10 -0.81 -0.88 -0.68 1 1 -1 0 0 0 0 0 0 1 0 1 242672_at Rftn1 raftlin, lipid raft linker 1 -0.11 0.08 0.34 0.20 0 1 -1 0 0 0 1 0 0 0 0 1 236505_at NUP62 Nucleoporin 62kDa -0.42 -0.73 -0.68 -0.59 1 1 1 0 0 0 0 0 0 1 0 0 203394_s_at HES1 hairy and enhancer of split 1, (Drosophila) 0.87 1.13 1.14 1.28 0 1 -1 0 0 0 0 0 0 0 0 1 241859_at PLCL1 phospholipase C-like 1 -0.29 -0.05 -0.11 0.10 0 1 -1 0 0 0 0 0 0 0 0 1 244791_at UBAC2 UBA domain containing 2 -0.43 -0.22 -0.12 -0.07 0 1 -1 0 0 0 1 0 0 0 0 1 230352_at PRPS2 Phosphoribosyl pyrophosphate synthetase 2 -0.32 -0.09 -0.02 0.07 0 1 -1 0 0 0 1 0 0 0 0 1 1558971_at THEMIS thymocyte selection associated 0.01 0.10 0.09 0.28 0 1 0 0 0 1 0 0 0 0 0 1 1559776_at gm2a GM2 ganglioside activator -0.28 -0.15 -0.21 0.02 0 1 0 0 0 1 0 0 0 0 0 1 204165_at WASF1 WAS protein family, member 1 -0.27 0.02 -0.16 0.20 1 1 0 0 0 1 0 0 0 1 1 1 240248_at C10orf46 chromosome 10 open reading frame 46 -0.45 -0.19 -0.29 -0.01 1 1 0 0 0 1 0 0 0 1 1 1 243375_at GRIK1 glutamate receptor, ionotropic, kainate 1 -0.15 -0.04 -0.14 0.13 0 1 0 0 0 1 0 0 0 0 1 1 204686_at IRS1 insulin receptor substrate 1 -0.04 0.07 -0.05 0.25 0 1 0 0 0 1 0 0 0 0 1 1 216117_at EXOSC2 exosome component 2 -0.28 -0.20 -0.31 -0.02 0 1 0 0 0 1 0 0 0 0 1 0 223681_s_at INADL InaD-like (Drosophila) -0.13 0.01 -0.10 0.19 0 1 0 0 0 1 0 0 0 0 1 1 228155_at C10orf58 chromosome 10 open reading frame 58 -0.17 0.03 0.00 0.21 0 1 -1 0 0 1 0 0 0 0 0 1 231873_at BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase)-0.61 -0.45 -0.60 -0.27 0 1 0 0 0 1 0 0 0 0 1 1 232740_at MCM3AP-AS MCM3AP antisense RNA (non-protein coding) -0.08 -0.03 -0.11 0.16 0 1 0 0 0 1 0 0 0 0 1 0 235172_at ------0.40 -0.18 -0.16 0.00 0 1 -1 0 0 0 0 0 0 0 0 1 1562255_at SYTL3 synaptotagmin-like 3 0.00 -0.30 0.09 -0.11 1 1 0 -1 0 0 0 0 1 1 0 0 1570255_s_at ANKRD20A1 ///ankyrin ANKRD20A2 repeat /// domain ANKRD20A3 20 family, /// memberANKRD20A4 A1 ////// ankyrinANKRD20B repeat /// domainLOC3750101.04 20 0.65family, member1.13 A20.84 /// ankyrin1 repeat domain1 20 family,0 member-1 A3 ///0 ankyrin 0repeat domain0 20 family,0 member1 A4 /// ankyrin1 repeat0 domain0 20B /// ankyrin repeat domain 20 family, member A pseudogene 201689_s_at TPD52 tumor protein D52 -0.18 -0.09 -0.09 0.10 0 1 0 0 0 1 0 0 0 0 0 1 201694_s_at EGR1 early growth response 1 -1.07 -0.84 -0.82 -0.65 0 1 -1 0 0 1 0 0 0 0 0 1 206398_s_at CD19 CD19 molecule -0.08 0.02 0.01 0.21 0 1 0 0 0 1 0 0 0 0 0 1 220643_s_at FAIM Fas apoptotic inhibitory molecule -0.71 -0.58 -0.62 -0.39 0 1 0 0 0 1 0 0 0 0 0 1 229553_at PGM2L1 phosphoglucomutase 2-like 1 0.03 0.17 0.19 0.36 0 1 0 0 0 1 0 0 0 0 0 1 229850_at KDSR 3-ketodihydrosphingosine reductase 0.06 0.28 0.16 0.47 0 1 0 0 0 1 0 0 0 0 1 1 229869_at ------0.12 0.22 0.16 0.41 0 1 0 0 0 1 0 0 0 0 0 1 231108_at FUS fused in sarcoma -0.22 -0.04 -0.11 0.15 0 1 0 0 0 1 0 0 0 0 0 1 232181_at PPARGC1B peroxisome proliferator-activated receptor gamma, coactivator 1 -0.34beta -0.22 -0.34 -0.04 0 1 0 0 0 1 0 0 0 0 1 1 242540_at DNHD1 dynein heavy chain domain 1 -0.30 -0.17 -0.27 0.02 0 1 0 0 0 1 0 0 0 0 1 1 243655_x_at SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin,-0.29 -0.21 subfamily-0.21 a, member-0.02 4 0 1 0 0 0 1 0 0 0 0 0 1 1559006_at ------0.31 -0.24 -0.33 -0.04 0 1 0 0 0 1 0 0 0 0 1 1 1569352_at FNIP2 folliculin interacting protein 2 -2.19 -1.96 -2.06 -1.77 0 1 0 0 0 1 0 0 0 0 0 1 242929_at Rhoh ras homolog gene family, member H -0.69 -0.39 -0.30 -0.19 1 1 -1 0 0 0 1 0 0 1 0 1 203940_s_at VASH1 vasohibin 1 -0.89 -0.85 -0.96 -0.64 0 1 0 0 0 1 0 0 0 0 1 0 218930_s_at TMEM106B transmembrane protein 106B -0.06 0.00 0.00 0.21 0 1 0 0 0 1 0 0 0 0 0 1 224435_at C10orf58 chromosome 10 open reading frame 58 -0.19 -0.08 -0.15 0.13 0 1 0 0 0 1 0 0 0 0 1 1 238470_at SYS1 SYS1 Golgi-localized integral membrane protein homolog (S. cerevisiae)-0.36 -0.25 -0.38 -0.04 0 1 0 0 0 1 0 0 0 0 1 1 239661_at AFF1 AF4/FMR2 family, member 1 -0.38 -0.23 -0.28 -0.02 0 1 0 0 0 1 0 0 0 0 0 1 1557113_at LOC283588 hypothetical LOC283588 -0.22 -0.11 -0.18 0.11 0 1 0 0 0 1 0 0 0 0 1 1 1565887_at TRPM7 Transient receptor potential cation channel, subfamily M, member-0.22 7 -0.15 -0.21 0.07 0 1 0 0 0 1 0 0 0 0 1 1 202814_s_at HEXIM1 hexamethylene bis-acetamide inducible 1 -0.28 -0.17 -0.19 0.05 0 1 0 0 0 1 0 0 0 0 0 1 206279_at PRKY protein kinase, Y-linked -0.08 -0.02 -0.07 0.20 0 1 0 0 0 1 0 0 0 0 1 1 212592_at IGJ immunoglobulin J polypeptide, linker protein for immunoglobulin alpha0.19 and0.30 mu polypeptides0.32 0.52 0 1 0 0 0 1 0 0 0 0 0 1 214705_at INADL InaD-like (Drosophila) 0.17 0.28 0.14 0.51 0 1 0 0 0 1 0 0 0 0 1 1 219922_s_at LTBP3 latent transforming growth factor beta binding protein 3 0.10 0.16 0.10 0.38 0 1 0 0 0 1 0 0 0 0 1 1 220068_at VPREB3 pre-B lymphocyte 3 0.02 0.19 0.21 0.41 0 1 -1 0 0 1 0 0 0 0 0 1 228170_at OLIG1 oligodendrocyte transcription factor 1 -1.91 -2.18 -2.00 -1.96 1 1 0 -1 0 0 0 0 0 1 0 0 200832_s_at SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.60 -0.35 -0.44 -0.12 0 1 0 0 0 1 0 0 0 0 1 1 202581_at HSPA1A /// HSPA1Bheat shock 70kDa protein 1A /// heat shock 70kDa protein 1B -0.14 0.11 0.09 0.34 0 1 -1 0 0 1 0 0 0 0 0 1 215462_at PLK3 polo-like kinase 3 -0.41 -0.37 -0.36 -0.15 0 1 0 0 0 1 0 0 0 0 0 1 217951_s_at PHF3 PHD finger protein 3 -0.15 -0.09 -0.04 0.14 0 1 0 0 0 1 0 0 0 0 0 1 229513_at STRBP spermatid perinuclear RNA binding protein -0.16 0.02 -0.05 0.25 0 1 0 0 0 1 0 0 0 0 1 1 234150_at ------0.20 0.25 0.23 0.48 0 1 0 0 0 1 0 0 0 0 0 1 240019_at ------0.24 -0.09 -0.05 0.14 0 1 0 0 0 1 0 0 0 0 0 1 205267_at POU2AF1 POU class 2 associating factor 1 -0.35 -0.21 -0.20 0.03 0 1 0 0 0 1 0 0 0 0 0 1 230896_at BEND4 BEN domain containing 4 -0.47 -0.33 -0.41 -0.09 0 1 0 0 0 1 0 0 0 0 1 1 239278_at ------0.01 0.10 0.12 0.34 0 1 0 0 0 1 0 0 0 0 0 1 205934_at PLCL1 phospholipase C-like 1 -0.43 -0.34 -0.35 -0.09 0 1 0 0 0 1 0 0 0 0 1 1 209321_s_at ADCY3 adenylate cyclase 3 0.30 0.38 0.40 0.63 0 1 0 0 0 1 0 0 0 0 0 1 233251_at STRBP Spermatid perinuclear RNA binding protein -0.44 -0.18 -0.16 0.07 0 1 -1 0 0 1 1 0 0 0 0 1 239649_at gtf2i /// LOC100093631general transcription factor II, i; general transcription factor II, i, pseudogene-0.46 -0.27 -0.34 -0.03 0 1 0 0 0 1 0 0 0 0 1 1 1558279_a_at KDSR 3-ketodihydrosphingosine reductase -0.28 0.00 -0.12 0.26 1 1 0 0 0 1 0 0 0 1 1 1 202759_s_at AKAP2 /// PALM2-AKAP2A kinase (PRKA) anchor protein 2 /// PALM2-AKAP2 readthrough -0.71 -0.60 -0.51 -0.34 0 1 0 0 0 1 0 0 0 0 0 1 211721_s_at ZNF551 zinc finger protein 551 -0.10 -0.10 -0.05 0.17 0 1 0 0 0 1 0 0 0 0 0 1 219518_s_at ELL3 /// SERINC4elongation factor RNA polymerase II-like 3 /// serine incorporator -0.344 -0.18 -0.16 0.08 0 1 0 0 0 1 0 0 0 0 0 1 242509_at C16orf74 chromosome 16 open reading frame 74 -0.35 -0.35 -0.38 -0.09 0 1 0 0 0 1 0 0 0 0 1 0 210845_s_at PLAUR plasminogen activator, urokinase receptor -1.40 -1.56 -1.93 -1.99 1 0 0 0 0 0 1 1 1 0 0 1 219869_s_at SLC39A8 solute carrier family 39 (zinc transporter), member 8 -0.33 -0.31 -0.58 -0.71 1 0 0 0 0 0 0 1 0 0 0 1 1553626_a_at C17orf57 chromosome 17 open reading frame 57 -0.16 0.25 0.27 -0.13 1 0 0 0 0 0 1 1 0 1 1 0 209267_s_at SLC39A8 solute carrier family 39 (zinc transporter), member 8 -0.17 -0.24 -0.57 -0.62 1 0 0 0 0 0 1 1 1 0 0 1 200612_s_at AP2B1 adaptor-related protein complex 2, beta 1 subunit 0.35 0.63 0.70 0.26 1 0 0 0 0 0 1 1 0 1 1 0 238727_at LOC440934 hypothetical LOC440934 0.68 0.59 0.18 0.22 1 0 0 0 0 0 1 1 0 0 0 1 223168_at RHOU ras homolog gene family, member U -0.73 -0.84 -1.18 -1.21 1 0 0 0 0 0 1 1 0 0 0 1 210042_s_at CTSZ cathepsin Z -0.32 -0.44 -0.74 -0.79 1 0 0 0 0 0 1 1 0 0 0 1 44783_s_at HEY1 hairy/enhancer-of-split related with YRPW motif 1 0.06 -0.09 -0.27 -0.42 1 0 0 0 0 0 1 1 0 0 0 1 216504_s_at SLC39A8 solute carrier family 39 (zinc transporter), member 8 -0.43 -0.42 -0.71 -0.75 1 0 0 0 0 0 1 1 1 0 0 1 230703_at MAPK1IP1L mitogen-activated protein kinase 1 interacting protein 1-like -0.21 0.04 0.00 -0.26 1 0 0 0 0 0 0 1 0 0 0 0 236228_at LOC100130744hypothetical LOC100130744 0.50 0.69 0.58 0.38 1 0 0 0 0 0 0 1 0 0 0 0 216392_s_at SEC23IP SEC23 interacting protein -0.44 -0.22 -0.22 -0.51 1 0 0 0 0 0 0 1 0 0 1 0 230085_at PDK3 pyruvate dehydrogenase kinase, isozyme 3 -0.02 0.22 0.21 -0.07 1 0 0 0 0 0 0 1 0 0 1 0 201200_at CREG1 cellular repressor of E1A-stimulated genes 1 -1.96 -1.81 -2.17 -2.09 1 0 0 0 0 0 0 1 1 0 0 0 213469_at PGAP1 post-GPI attachment to proteins 1 -0.60 -0.60 -0.81 -0.89 1 0 0 0 0 0 0 1 0 0 0 1 215169_at SLC35E2 solute carrier family 35, member E2 0.12 0.49 0.41 0.21 1 0 0 0 0 0 0 1 0 1 0 0 1563321_s_at MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila);0.25 0.44 translocated0.32 to,0.17 10 1 0 0 0 0 0 0 1 0 0 0 0 204926_at INHBA inhibin, beta A -0.70 -0.49 -0.63 -0.76 1 0 0 0 0 0 0 1 0 0 0 0 205088_at MAMLD1 mastermind-like domain containing 1 -0.66 -0.65 -0.91 -0.91 1 0 0 0 0 0 0 1 1 0 0 0 211732_x_at HNMT histamine N-methyltransferase 0.01 -0.08 -0.25 -0.36 1 0 0 0 0 0 0 1 0 0 0 1 204735_at PDE4A phosphodiesterase 4A, cAMP-specific -0.94 -1.08 -1.26 -1.35 1 0 0 0 0 0 1 1 0 0 0 1 208721_s_at ANAPC5 anaphase promoting complex subunit 5 0.10 0.25 0.28 -0.02 1 0 0 0 0 0 0 1 0 0 1 0 210519_s_at NQO1 NAD(P)H dehydrogenase, quinone 1 -0.86 -0.71 -1.13 -0.97 1 0 0 0 0 0 1 1 1 0 0 0 1557224_at FAR2 fatty acyl CoA reductase 2 -0.07 -0.17 -0.22 0.10 1 0 0 0 0 0 0 1 0 0 1 0 1559691_at NDUFS1 NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme-0.10 -0.28 Q reductase)-0.18 -0.02 1 0 0 0 0 0 0 1 0 0 0 0 1563147_at ------0.03 -0.07 0.05 0.20 1 0 0 0 0 0 0 1 0 0 0 0 1570566_at LOC100287529Hypothetical protein LOC100287529 -0.10 -0.27 -0.08 0.00 1 0 0 0 0 0 0 1 0 0 0 0 214778_at MEGF8 multiple EGF-like-domains 8 -0.23 -0.37 -0.29 -0.10 1 0 0 0 0 0 0 1 0 0 0 0 215086_at IBTK inhibitor of Bruton agammaglobulinemia tyrosine kinase -0.29 -0.44 -0.31 -0.17 1 0 0 0 0 0 0 1 0 0 0 0 234041_at ------1.07 -1.18 -1.18 -0.92 1 0 0 0 0 0 0 1 0 0 0 0 236582_at Cpsf6 cleavage and polyadenylation specific factor 6, 68kDa -0.27 -0.31 -0.17 -0.05 1 0 0 0 0 0 0 1 0 0 0 0 1555225_at C1orf43 chromosome 1 open reading frame 43 -0.49 -0.68 -0.56 -0.41 1 0 0 0 0 0 0 1 0 0 0 0 1556204_a_at LOC100507816hypothetical /// ZNF814 LOC100507816 /// zinc finger protein 814 -0.49 -0.42 -0.17 -0.15 1 0 0 0 0 0 1 1 0 0 0 1

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1558670_at Plekhm2 pleckstrin homology domain containing, family M (with RUN domain)-0.46 member-0.66 2 -0.54 -0.39 1 0 0 0 0 0 0 1 0 0 0 0 1562033_at ------0.16 -0.30 -0.31 -0.03 1 0 0 0 0 0 0 1 0 0 1 0 1565888_at tab2 mitogen-activated protein kinase kinase kinase 7 interacting protein0.06 2 -0.10 -0.06 0.17 1 0 0 0 0 0 0 1 0 0 0 0 1567032_s_at ZNF160 zinc finger protein 160 -0.06 -0.20 0.03 0.07 1 0 0 0 0 0 0 1 0 0 0 0 1570165_at CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 -0.87 -1.03 -0.96 -0.76 1 0 0 0 0 0 0 1 0 0 0 0 208268_at ADAM28 ADAM metallopeptidase domain 28 -0.36 -0.23 -0.12 0.04 1 0 0 0 0 0 0 1 0 0 0 1 209508_x_at CFLAR CASP8 and FADD-like apoptosis regulator -0.37 -0.54 -0.48 -0.27 1 0 0 0 0 0 0 1 0 0 0 0 214808_at ------0.08 -0.21 -0.12 0.06 1 0 0 0 0 0 0 1 0 0 0 0 215645_at FLCN folliculin -0.35 -0.56 -0.50 -0.29 1 0 0 0 0 0 0 1 0 0 0 0 215892_at ZNF440 Zinc finger protein 440 -0.07 -0.12 -0.01 0.15 1 0 0 0 0 0 0 1 0 0 0 0 217536_x_at ------0.04 -0.20 -0.08 0.08 1 0 0 0 0 0 0 1 0 0 0 0 227918_s_at ZYG11B zyg-11 homolog B (C. elegans) -0.72 -0.56 -0.36 -0.29 1 0 0 0 0 0 1 1 0 0 0 1 232425_at SNX25 sorting nexin 25 0.07 -0.06 0.18 0.20 1 0 0 0 0 0 0 1 0 0 0 0 232927_at TMTC2 transmembrane and tetratricopeptide repeat containing 2 0.02 -0.08 0.03 0.19 1 0 0 0 0 0 0 1 0 0 0 0 234210_x_at ACTR2 ARP2 actin-related protein 2 homolog (yeast) -0.42 -0.53 -0.45 -0.26 1 0 0 0 0 0 0 1 0 0 0 0 237346_at TGDS TDP-glucose 4,6-dehydratase 0.17 -0.02 0.13 0.25 1 0 0 0 0 0 0 1 0 0 0 0 239900_x_at ------0.10 -0.24 -0.18 0.04 1 0 0 0 0 0 0 1 0 0 0 0 242851_at KIAA1919 KIAA1919 -0.17 -0.29 -0.26 -0.03 1 0 0 0 0 0 0 1 0 0 0 0 1552729_at SNHG7 small nucleolar RNA host gene 7 (non-protein coding) 0.26 0.16 0.32 0.43 1 0 0 0 0 0 0 1 0 0 0 0 1554602_at RBM8A RNA binding motif protein 8A 0.44 0.30 0.53 0.57 1 0 0 0 0 0 0 1 0 0 0 0 1555425_x_at SSH2 slingshot homolog 2 (Drosophila) -0.11 -0.26 -0.14 0.02 1 0 0 0 0 0 0 1 0 0 0 0 1560095_s_at GNB5 guanine nucleotide binding protein (G protein), beta 5 0.00 -0.16 -0.04 0.11 1 0 0 0 0 0 0 1 0 0 0 0 1570048_at DNAJC24 DnaJ (Hsp40) homolog, subfamily C, member 24 -0.02 -0.16 -0.04 0.13 1 0 0 0 0 0 0 1 0 0 0 0 211317_s_at CFLAR CASP8 and FADD-like apoptosis regulator -0.46 -0.67 -0.58 -0.39 1 0 0 0 0 0 0 1 0 0 0 0 215083_at PSPC1 /// LOC642395paraspeckle component 1; paraspeckle protein 1 pseudogene -0.22 -0.41 -0.37 -0.13 1 0 0 0 0 0 0 1 0 0 0 0 215933_s_at HHEX hematopoietically expressed homeobox -0.77 -0.80 -0.61 -0.51 1 0 0 0 0 0 0 1 0 0 0 0 216029_at ------0.00 -0.15 -0.02 0.13 1 0 0 0 0 0 0 1 0 0 0 0 226825_s_at TMEM165 transmembrane protein 165 -0.50 -0.79 -0.65 -0.51 1 0 0 0 0 0 0 1 0 1 0 0 229514_at C14orf118 chromosome 14 open reading frame 118 -0.31 -0.46 -0.42 -0.18 1 0 0 0 0 0 0 1 0 0 0 0 232049_at ------0.09 -0.22 -0.10 0.06 1 0 0 0 0 0 0 1 0 0 0 0 232905_at GTF2H5 general transcription factor IIH, polypeptide 5 0.00 -0.13 -0.05 0.16 1 0 0 0 0 0 0 1 0 0 0 0 234596_at ------0.20 -0.36 -0.24 -0.07 1 0 0 0 0 0 0 1 0 0 0 0 237958_at MCPH1 microcephalin 1 -0.36 -0.32 -0.14 -0.04 1 0 0 0 0 0 0 1 0 0 0 1 238011_at C16orf72 chromosome 16 open reading frame 72 -1.03 -0.89 -0.76 -0.61 1 0 0 0 0 0 0 1 0 0 0 1 238635_at C5orf28 chromosome 5 open reading frame 28 -0.44 -0.32 -0.12 -0.04 1 0 0 0 0 0 0 1 0 0 0 1 241658_at ------0.45 -0.59 -0.47 -0.31 1 0 0 0 0 0 0 1 0 0 0 0 241774_at ------0.15 -0.26 -0.09 0.02 1 0 0 0 0 0 0 1 0 0 0 0 243042_at FAM73A family with sequence similarity 73, member A -0.07 -0.19 -0.08 0.08 1 0 0 0 0 0 0 1 0 0 0 0 243055_at NKTR natural killer-tumor recognition sequence 0.04 -0.10 0.05 0.17 1 0 0 0 0 0 0 1 0 0 0 0 1556035_s_at ZNF207 zinc finger protein 207 -0.15 -0.24 -0.11 0.04 1 0 0 0 0 0 0 1 0 0 0 0 1560332_at CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 -0.88 -1.01 -0.97 -0.72 1 0 0 0 0 0 0 1 0 0 0 0 205917_at ZNF264 zinc finger protein 264 -0.48 -0.62 -0.54 -0.33 1 0 0 0 0 0 0 1 0 0 0 0 215336_at AKAP11 A kinase (PRKA) anchor protein 11 0.10 -0.13 -0.06 0.17 1 0 0 0 0 0 0 1 0 0 0 0 217666_at SIDT1 SID1 transmembrane family, member 1 -0.23 -0.41 -0.25 -0.11 1 0 0 0 0 0 0 1 0 0 0 0 220494_s_at ------0.17 -0.03 0.09 0.26 1 0 0 0 0 0 0 1 0 0 0 0 220735_s_at SENP7 SUMO1/sentrin specific peptidase 7 -0.19 -0.16 0.09 0.13 1 0 0 0 0 0 0 1 0 0 0 1 221276_s_at SYNC syncoilin, intermediate filament protein -0.30 -0.31 -0.18 -0.02 1 0 0 0 0 0 0 1 0 0 0 1 229060_at YPEL2 yippee-like 2 (Drosophila) -0.13 -0.10 0.11 0.19 1 0 0 0 0 0 0 1 0 0 0 1 232418_at LZTFL1 leucine zipper transcription factor-like 1 -0.12 -0.29 -0.15 0.01 1 0 0 0 0 0 0 1 0 0 0 0 232991_at ARL17A /// ARL17BADP-ribosylation factor-like 17 pseudogene 1; ADP-ribosylation factor-like0.15 17-0.09 0.03 0.19 1 0 0 0 0 0 0 1 0 0 0 0 233224_at kpna3 karyopherin alpha 3 (importin alpha 4) -0.11 -0.24 -0.18 0.06 1 0 0 0 0 0 0 1 0 0 0 0 233440_at ------0.03 -0.21 -0.11 0.07 1 0 0 0 0 0 0 1 0 0 0 0 233596_at uimc1 ubiquitin interaction motif containing 1 -0.20 -0.35 -0.26 -0.06 1 0 0 0 0 0 0 1 0 0 0 0 234260_at CDC42SE2 CDC42 small effector 2 0.12 -0.04 -0.01 0.26 1 0 0 0 0 0 0 1 0 0 1 0 238932_at ------0.16 -0.30 -0.17 -0.01 1 0 0 0 0 0 0 1 0 0 0 0 239827_at C13orf15 Chromosome 13 open reading frame 15 -0.55 -0.51 -0.32 -0.21 1 0 0 0 0 0 0 1 0 0 0 1 243026_x_at XIAP X-linked inhibitor of apoptosis -0.55 -0.70 -0.63 -0.42 1 0 0 0 0 0 0 1 0 0 0 0 1555938_x_at VIM vimentin -0.21 -0.14 -0.01 0.16 1 0 0 0 0 0 0 1 0 0 0 1 1559044_at EXOSC1 exosome component 1 -0.21 -0.27 -0.06 0.04 1 0 0 0 0 0 0 1 0 0 0 0 1561924_at TOPBP1 topoisomerase (DNA) II binding protein 1 -0.15 -0.31 -0.23 -0.01 1 0 0 0 0 0 0 1 0 0 0 0 1566142_at GBF1 golgi-specific brefeldin A resistant guanine nucleotide exchange factor-0.26 1 -0.43 -0.38 -0.13 1 0 0 0 0 0 0 1 0 0 0 0 1569387_at CSGALNACT1 Chondroitin sulfate N-acetylgalactosaminyltransferase 1 0.28 0.07 0.24 0.38 1 0 0 0 0 0 0 1 0 0 0 0 208485_x_at CFLAR CASP8 and FADD-like apoptosis regulator -0.48 -0.68 -0.59 -0.38 1 0 0 0 0 0 0 1 0 0 0 0 215203_at GOLGA4 golgin A4 0.01 -0.13 -0.01 0.17 1 0 0 0 0 0 0 1 0 0 0 0 216614_at ITPR2 inositol 1,4,5-triphosphate receptor, type 2 -0.18 -0.34 -0.35 -0.04 1 0 0 0 0 0 0 1 0 0 1 0 231875_at KIF21A kinesin family member 21A -0.05 -0.18 0.05 0.12 1 0 0 0 0 0 0 1 0 0 0 0 232705_at LRRFIP2 Leucine rich repeat (in FLII) interacting protein 2 -0.12 -0.30 -0.20 0.00 1 0 0 0 0 0 0 1 0 0 0 0 233377_at ARID5B AT rich interactive domain 5B (MRF1-like) -0.20 -0.28 -0.14 0.01 1 0 0 0 0 0 0 1 0 0 0 0 233832_at ------0.19 -0.43 -0.34 -0.13 1 0 0 0 0 0 0 1 0 0 0 0 242337_at IGBP1 /// C14orf19chromosome 14 open reading frame 19; immunoglobulin (CD79A)-0.08 binding -0.24protein 1-0.09 0.06 1 0 0 0 0 0 0 1 0 0 0 0 1553145_at FLJ39653 hypothetical FLJ39653 -0.10 -0.25 -0.13 0.06 1 0 0 0 0 0 0 1 0 0 0 0 1553165_at SYNRG synergin, gamma -0.02 -0.17 -0.11 0.15 1 0 0 0 0 0 0 1 0 0 0 0 1556654_at ------0.22 -0.43 -0.35 -0.13 1 0 0 0 0 0 0 1 0 0 0 0 1557736_at NKTR natural killer-tumor recognition sequence -0.30 -0.45 -0.41 -0.15 1 0 0 0 0 0 0 1 0 0 1 0 1559121_s_at ARIH2 Ariadne homolog 2 (Drosophila) -0.30 -0.46 -0.39 -0.15 1 0 0 0 0 0 0 1 0 0 0 0 1559232_a_at slc33a1 solute carrier family 33 (acetyl-CoA transporter), member 1 -0.06 -0.31 -0.15 0.00 1 0 0 0 0 0 0 1 0 0 0 0 1562938_at GPAT2 /// LOC643219hypothetical /// LOC653924 protein LOC150763; similar to hCG1732629; similar to0.05 glycerol-3-phosphate-0.14 -0.07 acyltransferase,0.17 mitochondrial1 0 0 0 0 0 0 1 0 0 0 0 1565703_at SMAD4 SMAD family member 4 0.00 -0.23 -0.17 0.08 1 0 0 0 0 0 0 1 0 0 0 0 1565811_at Ppp3r1 protein phosphatase 3 (formerly 2B), regulatory subunit B, alpha isoform-0.02 -0.12 0.03 0.19 1 0 0 0 0 0 0 1 0 0 0 0 1568997_at POLR1E polymerase (RNA) I polypeptide E, 53kDa -0.16 -0.32 -0.17 -0.01 1 0 0 0 0 0 0 1 0 0 0 0 1570339_x_at ------0.62 -0.86 -0.73 -0.55 1 0 0 0 0 0 0 1 0 0 0 0 232556_at ------0.24 0.10 0.36 0.41 1 0 0 0 0 0 0 1 0 0 0 0 232704_s_at LRRFIP2 leucine rich repeat (in FLII) interacting protein 2 -0.28 -0.49 -0.38 -0.19 1 0 0 0 0 0 0 1 0 0 0 0 239954_at ZNF160 zinc finger protein 160 -0.13 -0.46 -0.31 -0.15 1 0 0 0 0 0 0 1 0 1 0 0 242403_at ube2d3 /// UBE2D3Pubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, yeast); ubiquitin-conjugating-0.05 -0.26 -0.16 enzyme 0.05E2D 3 pseudogene1 0 0 0 0 0 0 1 0 0 0 0 243108_at RANBP9 RAN binding protein 9 -0.56 -0.52 -0.32 -0.21 1 0 0 0 0 0 0 1 0 0 0 1 1557064_s_at HGSNAT heparan-alpha-glucosaminide N-acetyltransferase -0.31 -0.45 -0.30 -0.13 1 0 0 0 0 0 0 1 0 0 0 0 1559528_at LOC100129917hypothetical LOC100129917 -0.39 -0.48 -0.29 -0.16 1 0 0 0 0 0 0 1 0 0 0 0 1559739_at CHPT1 Choline phosphotransferase 1 0.25 0.06 0.18 0.38 1 0 0 0 0 0 0 1 0 0 0 0 1565804_at ATXN1 ataxin 1 -0.61 -0.79 -0.80 -0.47 1 0 0 0 0 0 0 1 0 0 1 0 1566448_at CD6 CD6 molecule 0.44 0.29 0.46 0.61 1 0 0 0 0 0 0 1 0 0 0 0 1569927_at Msh2 mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli) -0.09 -0.29 -0.12 0.03 1 0 0 0 0 0 0 1 0 0 0 0 1570441_at NAPB N-ethylmaleimide-sensitive factor attachment protein, beta -0.13 -0.30 -0.11 0.02 1 0 0 0 0 0 0 1 0 0 0 0 210701_at CFDP1 craniofacial development protein 1 -0.24 -0.46 -0.46 -0.14 1 0 0 0 0 0 0 1 0 0 1 0 215281_x_at POGZ pogo transposable element with ZNF domain -0.13 -0.32 -0.21 0.00 1 0 0 0 0 0 0 1 0 0 0 0 224402_s_at FCRL4 Fc receptor-like 4 -0.66 -0.67 -0.36 -0.35 1 0 0 0 0 0 0 1 1 0 0 1 233374_at Hic2 hypermethylated in cancer 2 -0.57 -0.69 -0.54 -0.38 1 0 0 0 0 0 0 1 0 0 0 0 235680_at Stat3 signal transducer and activator of transcription 3 (acute-phase response-0.04 factor)-0.33 -0.17 -0.01 1 0 0 0 0 0 0 1 0 1 0 0 240513_at EIF3M Eukaryotic translation initiation factor 3, subunit M -0.05 -0.18 -0.01 0.14 1 0 0 0 0 0 0 1 0 0 0 0 243037_at FUBP1 far upstream element (FUSE) binding protein 1 -0.10 -0.26 -0.26 0.05 1 0 0 0 0 0 0 1 0 0 1 0 1555476_at IREB2 iron-responsive element binding protein 2 -0.05 -0.19 0.05 0.14 1 0 0 0 0 0 0 1 0 0 0 0 1569098_s_at TP53BP1 tumor protein p53 binding protein 1 -0.29 -0.43 -0.23 -0.10 1 0 0 0 0 0 0 1 0 0 0 0 215213_at NUP54 nucleoporin 54kDa 0.00 -0.25 -0.11 0.08 1 0 0 0 0 0 0 1 0 0 0 0 215599_at GUSBP3 glucuronidase, beta pseudogene 3 0.20 0.07 0.28 0.40 1 0 0 0 0 0 0 1 0 0 0 0 232622_at Prkce protein kinase C, epsilon -0.05 -0.21 -0.08 0.12 1 0 0 0 0 0 0 1 0 0 0 0 243771_at PPP1R16B protein phosphatase 1, regulatory (inhibitor) subunit 16B -0.27 -0.30 -0.13 0.04 1 0 0 0 0 0 0 1 0 0 0 1 1554543_at SPAG9 sperm associated antigen 9 -0.85 -1.05 -1.01 -0.71 1 0 0 0 0 0 0 1 0 0 0 0 1559964_at FLJ38717 FLJ38717 protein -0.22 -0.51 -0.40 -0.17 1 0 0 0 0 0 0 1 0 1 0 0 1568964_x_at SPN sialophorin 0.00 -0.18 -0.08 0.16 1 0 0 0 0 0 0 1 0 0 0 0

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215013_s_at USP34 ubiquitin specific peptidase 34 -0.15 -0.37 -0.25 -0.03 1 0 0 0 0 0 0 1 0 0 0 0 216783_at C15orf60 chromosome 15 open reading frame 60 -0.63 -0.80 -0.68 -0.46 1 0 0 0 0 0 0 1 0 0 0 0 220710_at C15orf28 chromosome 15 open reading frame 28 -0.24 -0.42 -0.35 -0.08 1 0 0 0 0 0 0 1 0 0 1 0 233458_at POLR3E polymerase (RNA) III (DNA directed) polypeptide E (80kD) 0.01 -0.25 -0.09 0.09 1 0 0 0 0 0 0 1 0 1 0 0 241869_at APOL6 apolipoprotein L, 6 -0.06 -0.27 -0.14 0.08 1 0 0 0 0 0 0 1 0 0 0 0 243878_at FOXP1 forkhead box P1 -0.06 -0.04 0.14 0.30 1 0 0 0 0 0 0 1 0 0 0 1 39313_at WNK1 WNK lysine deficient protein kinase 1 -0.33 -0.52 -0.41 -0.18 1 0 0 0 0 0 0 1 0 0 0 0 1552622_s_at LOC441259 /// PMS2POLR2J2 postmeiotic segregation increased 2 (S. cerevisiae)-like /// polymerase-0.19 -0.34 (RNA) -0.16II (DNA directed)0.01 polypeptide1 J20 0 0 0 0 0 1 0 0 0 0 1563226_at SLC38A10 solute carrier family 38, member 10 -0.35 -0.55 -0.40 -0.19 1 0 0 0 0 0 0 1 0 0 0 0 1566485_at FHIT fragile histidine triad gene -0.24 -0.35 -0.16 0.00 1 0 0 0 0 0 0 1 0 0 0 0 215521_at PHC3 polyhomeotic homolog 3 (Drosophila) -0.12 -0.36 -0.25 -0.01 1 0 0 0 0 0 0 1 0 0 0 0 217591_at Skil SKI-like oncogene -0.68 -0.86 -0.76 -0.51 1 0 0 0 0 0 0 1 0 0 0 0 1570439_at MAP3K4 mitogen-activated protein kinase kinase kinase 4 -0.24 -0.44 -0.41 -0.08 1 0 0 0 0 0 0 1 0 0 1 0 242029_at FNDC3B Fibronectin type III domain containing 3B -1.21 -1.45 -1.32 -1.09 1 0 0 0 0 0 0 1 0 0 0 0 1559154_at SNX1 sorting nexin 1 -0.27 -0.49 -0.43 -0.11 1 0 0 0 0 0 0 1 0 0 1 0 224321_at TMEFF2 transmembrane protein with EGF-like and two follistatin-like domains-0.89 2 -0.87 -0.64 -0.50 1 0 0 0 0 0 0 1 0 0 0 1 228643_at ------1.14 -1.03 -0.69 -0.66 1 0 0 0 0 0 0 1 0 0 0 1 238013_at PLEKHA2 pleckstrin homology domain containing, family A (phosphoinositide-0.88 binding-0.89 specific)-0.62 member-0.52 2 1 0 0 0 0 0 0 1 0 0 0 1 241702_at HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA-0.33 binding-0.42 protein 1,-0.20 37kDa)-0.04 1 0 0 0 0 0 0 1 0 0 0 1 1557571_at VPS13D Vacuolar protein sorting 13 homolog D (S. cerevisiae) -0.65 -0.76 -0.49 -0.34 1 0 0 0 0 0 0 1 0 0 0 1 1559500_at VPS8 vacuolar protein sorting 8 homolog (S. cerevisiae) -0.77 -0.85 -0.58 -0.44 1 0 0 0 0 0 0 1 0 0 0 1 1560741_at SNRPN small nuclear ribonucleoprotein polypeptide N 0.15 -0.11 0.05 0.30 1 0 0 0 0 0 0 1 0 0 0 0 1569091_at zmym2 zinc finger, MYM-type 2 -0.45 -0.71 -0.61 -0.30 1 0 0 0 0 0 0 1 0 0 1 0 1569503_at HEATR5B HEAT repeat containing 5B -0.27 -0.52 -0.42 -0.11 1 0 0 0 0 0 0 1 0 0 1 0 215262_at ------0.07 -0.18 0.10 0.24 1 0 0 0 0 0 0 1 0 0 0 1 240482_at HDAC3 histone deacetylase 3 -0.38 -0.49 -0.24 -0.08 1 0 0 0 0 0 0 1 0 0 0 1 1560422_at paaF1 proteasomal ATPase-associated factor 1 0.16 -0.13 0.03 0.30 1 0 0 0 0 0 0 1 0 1 1 0 1561181_at ARID5B AT rich interactive domain 5B (MRF1-like) -0.34 -0.64 -0.48 -0.20 1 0 0 0 0 0 0 1 0 0 0 0 1559347_at CNOT4 CCR4-NOT transcription complex, subunit 4 -0.14 -0.47 -0.32 0.02 1 0 0 0 0 0 0 1 0 1 1 0 221085_at TNFSF15 tumor necrosis factor (ligand) superfamily, member 15 -0.46 -0.91 -0.76 -0.34 1 0 0 0 0 0 0 1 0 0 0 0 212942_s_at KIAA1199 KIAA1199 -1.39 -1.42 -2.22 -2.30 1 0 0 0 0 0 1 1 1 0 0 1 203939_at NT5E 5'-nucleotidase, ecto (CD73) -0.70 -0.87 -1.47 -1.54 1 0 0 0 0 0 1 1 1 0 0 1 222939_s_at SLC16A10 solute carrier family 16, member 10 (aromatic amino acid transporter)-1.75 -1.90 -2.38 -2.49 1 0 0 0 0 0 1 1 1 0 0 1 218468_s_at GREM1 gremlin 1 -3.00 -3.15 -3.90 -3.74 1 0 0 0 0 0 1 1 0 0 0 1 202948_at IL1R1 interleukin 1 receptor, type I -0.37 -0.54 -1.16 -1.04 1 0 0 0 0 0 1 1 1 0 0 1 1558871_at ------0.55 -0.62 -1.13 -1.12 1 0 0 0 0 0 0 1 0 0 0 1 205403_at IL1R2 interleukin 1 receptor, type II -0.87 -0.80 -1.30 -1.30 1 0 0 0 0 0 0 1 0 0 0 1 1553995_a_at NT5E 5'-nucleotidase, ecto (CD73) -0.47 -0.52 -0.97 -0.99 1 0 0 0 0 0 1 1 1 0 0 1 207016_s_at ALDH1A2 aldehyde dehydrogenase 1 family, member A2 -1.44 -1.48 -2.03 -1.94 1 0 0 0 0 0 0 1 0 0 0 1 225436_at FAM108C1 family with sequence similarity 108, member C1 -1.06 -1.07 -1.57 -1.54 1 0 0 0 0 0 1 1 1 0 0 1 1553994_at NT5E 5'-nucleotidase, ecto (CD73) -0.40 -0.39 -0.77 -0.83 1 0 0 0 0 0 1 1 1 0 0 1 211372_s_at IL1R2 interleukin 1 receptor, type II -0.72 -0.63 -1.00 -1.05 1 0 0 0 0 0 0 1 0 0 0 0 224918_x_at MGST1 microsomal glutathione S-transferase 1 -2.16 -2.20 -2.78 -2.62 1 0 0 0 0 0 1 1 1 0 0 1 236220_at ------2.42 -2.39 -2.78 -2.81 1 0 0 0 0 0 0 1 0 0 0 1 211776_s_at EPB41L3 erythrocyte membrane protein band 4.1-like 3 -1.33 -1.49 -1.78 -1.88 1 0 0 0 0 0 0 1 0 0 0 1 214866_at PLAUR plasminogen activator, urokinase receptor -1.69 -1.72 -2.11 -2.12 1 0 0 0 0 0 1 1 1 0 0 1 219093_at PID1 phosphotyrosine interaction domain containing 1 -1.03 -1.11 -1.55 -1.51 1 0 0 0 0 0 1 1 1 0 0 1 223952_x_at DHRS9 dehydrogenase/reductase (SDR family) member 9 -2.07 -2.15 -2.48 -2.53 1 0 0 0 0 0 0 1 0 0 0 1 231736_x_at MGST1 microsomal glutathione S-transferase 1 -2.15 -2.23 -2.76 -2.61 1 0 0 0 0 0 1 1 1 0 0 1 203821_at HBEGF heparin-binding EGF-like growth factor -2.26 -2.43 -2.79 -2.81 1 0 0 0 0 0 1 1 0 0 0 1 210664_s_at TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation-0.62 inhibitor)-0.58 -1.01 -0.96 1 0 0 0 0 0 1 1 1 0 0 1 203058_s_at PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2 -0.88 -0.91 -1.18 -1.28 1 0 0 0 0 0 1 1 0 0 0 1 218451_at CDCP1 CUB domain containing protein 1 -0.13 -0.28 -0.61 -0.65 1 0 0 0 0 0 1 1 0 0 0 1 222757_s_at ZAK sterile alpha motif and leucine zipper containing kinase AZK -0.65 -0.77 -1.09 -1.14 1 0 0 0 0 0 1 1 1 0 0 1 225665_at ZAK sterile alpha motif and leucine zipper containing kinase AZK -0.74 -0.82 -1.33 -1.19 1 0 0 0 0 0 1 1 1 0 0 1 229510_at MS4A14 membrane-spanning 4-domains, subfamily A, member 14 -1.37 -1.52 -1.87 -1.89 1 0 0 0 0 0 1 1 0 0 0 1 203510_at MET met proto-oncogene (hepatocyte growth factor receptor) -0.65 -0.71 -1.16 -1.06 1 0 0 0 0 0 1 1 1 0 0 1 205863_at S100A12 S100 calcium binding protein A12 -1.04 -1.15 -1.57 -1.50 1 0 0 0 0 0 1 1 0 0 0 1 209906_at C3AR1 complement component 3a receptor 1 -0.39 -0.54 -0.77 -0.89 1 0 0 0 0 0 0 1 0 0 0 1 227034_at ANKRD57 ankyrin repeat domain 57 -1.45 -1.61 -2.06 -1.96 1 0 0 0 0 0 1 1 1 0 0 1 209833_at CRADD CASP2 and RIPK1 domain containing adaptor with death domain -0.61 -0.63 -0.92 -0.97 1 0 0 0 0 0 1 1 1 0 0 1 215977_x_at GK glycerol kinase -1.22 -1.32 -1.51 -1.66 1 0 0 0 0 0 0 1 0 0 0 1 223519_at ZAK sterile alpha motif and leucine zipper containing kinase AZK -0.89 -0.90 -1.33 -1.23 1 0 0 0 0 0 1 1 1 0 0 1 224009_x_at DHRS9 dehydrogenase/reductase (SDR family) member 9 -2.17 -2.27 -2.64 -2.61 1 0 0 0 0 0 0 1 0 0 0 1 213763_at HIPK2 homeodomain interacting protein kinase 2 -0.76 -0.59 -0.77 -0.93 1 0 0 0 0 0 0 1 0 0 0 0 217167_x_at GK glycerol kinase -1.01 -1.11 -1.33 -1.44 1 0 0 0 0 0 0 1 0 0 0 1 38037_at HBEGF heparin-binding EGF-like growth factor -2.13 -2.26 -2.58 -2.59 1 0 0 0 0 0 1 1 0 0 0 1 204575_s_at MMP19 matrix metallopeptidase 19 -2.02 -2.10 -2.42 -2.42 1 0 0 0 0 0 1 1 1 0 0 1 207387_s_at GK glycerol kinase -1.13 -1.25 -1.52 -1.57 1 0 0 0 0 0 1 1 0 0 0 1 212657_s_at IL1RN interleukin 1 receptor antagonist -2.48 -2.39 -2.87 -2.71 1 0 0 0 0 0 0 1 1 0 0 0 213258_at TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation-0.76 inhibitor)-0.82 -1.24 -1.14 1 0 0 0 0 0 1 1 1 0 0 1 215966_x_at GK3P glycerol kinase 3 pseudogene -1.21 -1.33 -1.54 -1.65 1 0 0 0 0 0 0 1 0 0 0 1 217999_s_at PHLDA1 pleckstrin homology-like domain, family A, member 1 -1.67 -1.77 -2.03 -2.08 1 0 0 0 0 0 0 1 0 0 0 1 219915_s_at SLC16A10 solute carrier family 16, member 10 (aromatic amino acid transporter)-1.89 -1.97 -2.15 -2.29 1 0 0 0 0 0 0 1 0 0 0 1 202897_at SIRPA signal-regulatory protein alpha -1.22 -1.30 -1.56 -1.61 1 0 0 0 0 0 1 1 0 0 0 1 212659_s_at IL1RN interleukin 1 receptor antagonist -2.65 -2.59 -2.76 -2.90 1 0 0 0 0 0 0 1 0 0 0 0 237867_s_at PID1 phosphotyrosine interaction domain containing 1 -1.37 -1.41 -1.72 -1.73 1 0 0 0 0 0 0 1 0 0 0 1 201666_at TIMP1 TIMP metallopeptidase inhibitor 1 -1.09 -1.09 -1.34 -1.39 1 0 0 0 0 0 0 1 0 0 0 1 204614_at SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 0.34 0.29 -0.06 -0.01 1 0 0 0 0 0 1 1 1 0 0 1 215447_at TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation-0.40 inhibitor)-0.34 -0.48 -0.64 1 0 0 0 0 0 0 1 0 0 0 0 219496_at ANKRD57 ankyrin repeat domain 57 -1.38 -1.54 -1.91 -1.84 1 0 0 0 0 0 1 1 1 0 0 1 228918_at LOC100288617Hypothetical protein LOC100288617 -2.20 -2.35 -2.74 -2.65 1 0 0 0 0 0 1 1 0 0 0 1 203060_s_at PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2 -0.76 -0.86 -1.01 -1.15 1 0 0 0 0 0 0 1 0 0 0 1 217998_at PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.88 -0.90 -1.06 -1.19 1 0 0 0 0 0 0 1 0 0 0 1 222881_at HPSE heparanase -1.88 -2.01 -2.23 -2.30 1 0 0 0 0 0 0 1 0 0 0 1 223918_at ACSL6 acyl-CoA synthetase long-chain family member 6 -0.86 -0.85 -1.00 -1.14 1 0 0 0 0 0 0 1 0 0 0 1 229521_at FLJ36031 hypothetical protein FLJ36031 -0.69 -0.69 -0.95 -0.98 1 0 0 0 0 0 0 1 0 0 0 1 201422_at IFI30 interferon, gamma-inducible protein 30 -2.00 -2.15 -2.31 -2.44 1 0 0 0 0 0 0 1 0 0 0 1 201489_at PPIF peptidylprolyl isomerase F -1.08 -1.21 -1.51 -1.49 1 0 0 0 0 0 1 1 1 0 0 1 210510_s_at NRP1 neuropilin 1 -0.74 -0.87 -1.18 -1.15 1 0 0 0 0 0 1 1 1 0 0 1 212698_s_at SEPT10 septin 10 -1.33 -1.34 -1.77 -1.62 1 0 0 0 0 0 1 1 1 0 0 1 205382_s_at CFD complement factor D (adipsin) -0.86 -0.91 -1.10 -1.17 1 0 0 0 0 0 0 1 0 0 0 1 205568_at AQP9 aquaporin 9 -0.73 -0.67 -0.98 -0.94 1 0 0 0 0 0 0 1 1 0 0 0 207610_s_at EMR2 egf-like module containing, mucin-like, hormone receptor-like 2 -0.98 -1.04 -1.34 -1.31 1 0 0 0 0 0 0 1 0 0 0 1 203936_s_at MMP9 matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa -1.11type IV collagenase)-1.21 -1.49 -1.48 1 0 0 0 0 0 1 1 0 0 0 1 236345_at TBXAS1 thromboxane A synthase 1 (platelet) -1.04 -0.98 -1.28 -1.24 1 0 0 0 0 0 0 1 0 0 0 0 1553224_at LUZP1 leucine zipper protein 1 -0.14 -0.22 -0.09 0.05 1 0 0 0 0 0 0 1 0 0 0 0 204004_at PAWR PRKC, apoptosis, WT1, regulator -0.08 -0.16 -0.01 0.11 1 0 0 0 0 0 0 1 0 0 0 0 206828_at TXK TXK tyrosine kinase 0.43 0.32 0.48 0.58 1 0 0 0 0 0 0 1 0 0 0 0 208206_s_at RASGRP2 RAS guanyl releasing protein 2 (calcium and DAG-regulated) 0.63 0.46 0.60 0.73 1 0 0 0 0 0 0 1 0 0 0 0 215874_at ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 -0.81 -1.08 -0.92 -0.82 1 0 0 0 0 0 0 1 0 1 0 0 232279_at PHF15 PHD finger protein 15 0.15 0.04 0.09 0.32 1 0 0 0 0 0 0 1 0 0 0 0 1556655_s_at ------0.08 -0.22 -0.15 0.06 1 0 0 0 0 0 0 1 0 0 0 0 211862_x_at CFLAR CASP8 and FADD-like apoptosis regulator -0.48 -0.68 -0.60 -0.40 1 0 0 0 0 0 0 1 0 0 0 0 210948_s_at LEF1 lymphoid enhancer-binding factor 1 -0.06 -0.06 0.32 0.23 1 0 0 0 0 0 1 1 1 0 0 1 232392_at SFRS3 Splicing factor, arginine/serine-rich 3 0.61 0.48 0.73 0.77 1 0 0 0 0 0 0 1 0 0 0 0 1558748_at NAPEPLD N-acyl phosphatidylethanolamine phospholipase D 0.15 -0.05 0.06 0.26 1 0 0 0 0 0 0 1 0 0 0 0 244665_at itga6 integrin, alpha 6 0.55 0.37 0.49 0.68 1 0 0 0 0 0 0 1 0 0 0 0 207492_at NGLY1 N-glycanase 1 -0.04 -0.22 -0.08 0.09 1 0 0 0 0 0 0 1 0 0 0 0

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216379_x_at CD24 CD24 molecule 0.21 0.10 0.33 0.42 1 0 0 0 0 0 0 1 0 0 0 0 242201_at LOC730323 /// postmeioticPMS2L2 /// segregationPMS2L5 /// LOC100132832increased 2-like 5; postmeiotic segregation0.22 increased0.02 2-like 0.125-like; similar0.33 to postmeiotic1 segregation0 increased0 2-like0 2; postmeiotic0 0 segregation0 increased1 2-like 2 pseudogene0 0 0 0 243932_at col19a1 collagen, type XIX, alpha 1 -0.13 -0.18 -0.01 0.14 1 0 0 0 0 0 0 1 0 0 0 1 224403_at FCRL4 Fc receptor-like 4 -0.56 -0.61 -0.40 -0.29 1 0 0 0 0 0 0 1 0 0 0 1 235385_at MARCH1 membrane-associated ring finger (C3HC4) 1 -0.06 0.10 0.29 0.43 1 0 0 0 0 0 1 1 0 0 0 1 210511_s_at INHBA inhibin, beta A -0.97 -1.06 -1.29 -1.32 0 0 0 0 0 0 0 0 0 0 0 1 209959_at NR4A3 nuclear receptor subfamily 4, group A, member 3 -0.76 -0.89 -0.98 -1.15 0 0 0 0 0 0 0 0 0 0 0 1 225342_at AK4 adenylate kinase 4 0.12 0.12 -0.19 -0.14 1 0 0 0 0 0 0 0 1 0 0 0 217738_at NAMPT nicotinamide phosphoribosyltransferase -0.05 -0.19 -0.34 -0.44 0 0 0 0 0 0 1 0 0 0 0 1 207072_at IL18RAP interleukin 18 receptor accessory protein 0.26 0.16 0.07 -0.08 0 0 0 0 0 0 0 0 0 0 0 1 235179_at ZNF641 zinc finger protein 641 -0.19 0.12 0.11 -0.12 1 0 0 0 0 0 0 0 0 1 0 0 202007_at NID1 nidogen 1 -1.62 -1.57 -1.84 -1.80 1 0 0 0 0 0 0 0 1 0 0 0 224523_s_at C3orf26 chromosome 3 open reading frame 26 -0.16 -0.23 -0.43 -0.46 0 0 0 0 0 0 0 0 0 0 0 1 1564160_at DTHD1 death domain containing 1 -0.08 0.15 0.18 -0.08 0 0 0 0 0 0 1 0 0 0 0 0 204493_at BID BH3 interacting domain death agonist -0.80 -0.68 -0.98 -0.91 1 0 0 0 0 0 0 0 1 0 0 0 217388_s_at KYNU kynureninase (L-kynurenine hydrolase) -0.92 -0.94 -1.21 -1.16 1 0 0 0 0 0 1 0 1 0 0 0 217739_s_at NAMPT nicotinamide phosphoribosyltransferase -0.03 -0.15 -0.35 -0.37 0 0 0 0 0 0 1 0 0 0 0 1 202827_s_at MMP14 matrix metallopeptidase 14 (membrane-inserted) 0.01 -0.14 -0.22 -0.34 0 0 0 0 0 0 0 0 0 0 0 1 204385_at KYNU kynureninase (L-kynurenine hydrolase) -1.10 -1.13 -1.40 -1.34 0 0 0 0 0 0 1 0 0 0 0 0 228570_at BTBD11 BTB (POZ) domain containing 11 0.05 -0.10 -0.20 -0.31 0 0 0 0 0 0 0 0 0 0 0 1 239385_at TFG TRK-fused gene -0.15 0.13 0.03 -0.08 1 0 0 0 0 0 0 0 0 1 0 0 206380_s_at CFP complement factor properdin -0.17 -0.29 -0.37 -0.49 0 0 0 0 0 0 0 0 0 0 0 1 210866_s_at CNOT4 CCR4-NOT transcription complex, subunit 4 -0.09 0.14 0.26 -0.06 0 0 0 0 0 0 1 0 0 0 1 0 226189_at ITGB8 integrin, beta 8 -0.59 -0.66 -0.70 -0.87 0 0 0 0 0 0 0 0 0 0 0 1 228080_at LAYN layilin 0.24 0.16 0.08 -0.04 0 0 0 0 0 0 0 0 0 0 0 1 201468_s_at NQO1 NAD(P)H dehydrogenase, quinone 1 -0.57 -0.45 -0.78 -0.64 1 0 0 0 0 0 0 0 1 0 0 0 211725_s_at BID BH3 interacting domain death agonist -0.61 -0.58 -0.84 -0.77 1 0 0 0 0 0 0 0 1 0 0 0 224588_at XIST X (inactive)-specific transcript (non-protein coding) 0.44 0.29 0.20 0.10 0 0 0 0 0 0 0 0 0 0 0 1 229272_at FNBP4 formin binding protein 4 -0.09 0.18 0.27 -0.01 1 0 0 0 0 0 1 0 0 1 1 0 233261_at EBF1 Early B-cell factor 1 0.18 0.25 0.34 0.06 0 0 0 0 0 0 0 0 0 0 1 0 242781_at FAM199X family with sequence similarity 199, X-linked -0.33 -0.06 -0.05 -0.25 1 0 0 0 0 0 1 0 0 1 0 0 244490_at ------0.23 -0.02 0.06 -0.20 0 0 0 0 0 0 0 0 0 0 1 0 1558299_at Sirpa signal-regulatory protein alpha -0.86 -0.98 -1.13 -1.15 0 0 0 0 0 0 1 0 0 0 0 1 200917_s_at SRPR signal recognition particle receptor (docking protein) -0.22 0.01 0.11 -0.17 0 0 0 0 0 0 0 0 0 0 1 0 204348_s_at AK4 adenylate kinase 4 0.32 0.44 0.17 0.26 1 0 0 0 0 0 0 0 1 0 0 0 205220_at GPR109B G protein-coupled receptor 109B 0.32 0.35 0.01 0.17 1 0 0 0 0 0 1 0 1 0 0 0 210663_s_at KYNU kynureninase (L-kynurenine hydrolase) -0.97 -1.04 -1.24 -1.22 0 0 0 0 0 0 1 0 0 0 0 0 213998_s_at DDX17 DEAD (Asp-Glu-Ala-Asp) box polypeptide 17 0.29 0.37 0.53 0.19 0 0 0 0 0 0 0 0 0 0 1 0 220122_at MCTP1 multiple C2 domains, transmembrane 1 -0.25 -0.09 -0.43 -0.27 1 0 0 0 0 0 0 0 1 0 0 0 224917_at MIR21 microRNA 21 -0.67 -0.40 -0.48 -0.58 1 0 0 0 0 0 0 0 0 1 0 0 227143_s_at BID BH3 interacting domain death agonist -0.69 -0.62 -0.90 -0.80 1 0 0 0 0 0 0 0 1 0 0 0 235526_at SOX6 SRY (sex determining region Y)-box 6 0.47 0.51 0.63 0.33 0 0 0 0 0 0 0 0 0 0 1 0 241661_at JMJD1C jumonji domain containing 1C -0.25 -0.01 0.03 -0.20 0 0 0 0 0 0 1 0 0 0 0 0 1554958_at ZNF641 zinc finger protein 641 -0.43 -0.25 -0.15 -0.42 0 0 0 0 0 0 1 0 0 0 1 0 1555125_at GCFC1 GC-rich sequence DNA-binding factor 1 -0.12 0.22 0.29 0.05 1 0 0 0 0 0 1 0 0 1 0 0 207391_s_at PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha 0.62 0.39 0.45 0.23 0 0 0 0 0 0 0 0 0 0 0 1 212240_s_at PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) -0.02 0.09 0.18 -0.08 0 0 0 0 0 0 0 0 0 0 1 0 217078_s_at CD300A CD300a molecule -0.16 -0.33 -0.32 -0.50 0 0 0 0 0 0 0 0 0 0 0 1 243821_at MRPS31 mitochondrial ribosomal protein S31 -0.19 0.05 0.08 -0.12 0 0 0 0 0 0 1 0 0 0 0 0 244267_at Satb1 SATB homeobox 1 -0.31 0.02 0.00 -0.15 1 0 0 0 0 0 0 0 0 1 0 0 201235_s_at BTG2 BTG family, member 2 -0.47 -0.15 -0.16 -0.31 1 0 0 0 0 0 1 0 0 1 0 0 201683_x_at TOX4 TOX high mobility group box family member 4 -0.27 0.02 0.00 -0.14 1 0 0 0 0 0 1 0 0 1 0 0 203990_s_at KDM6A lysine (K)-specific demethylase 6A -0.18 0.12 0.19 -0.04 1 0 0 0 0 0 1 0 0 1 0 0 211506_s_at IL8 interleukin 8 -0.16 -0.31 -0.41 -0.48 0 0 0 0 0 0 0 0 0 0 0 1 211697_x_at PNO1 partner of NOB1 homolog (S. cerevisiae) 0.61 0.48 0.65 0.32 0 0 0 0 0 0 0 0 0 0 1 1 213817_at IRAK3 interleukin-1 receptor-associated kinase 3 -1.57 -1.71 -1.95 -1.86 0 0 0 0 0 0 1 0 0 0 0 1 243824_at LOC100505956hypothetical LOC100505956 0.91 0.65 1.07 0.49 0 0 0 0 0 0 0 0 0 0 1 1 36711_at MAFF v-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian)-0.64 -0.57 -0.88 -0.73 1 0 0 0 0 0 0 0 1 0 0 0 1555058_a_at LPGAT1 lysophosphatidylglycerol acyltransferase 1 -0.50 -0.15 -0.35 -0.29 1 0 0 0 0 0 0 0 0 1 0 0 1555368_x_at ZNF479 zinc finger protein 479 0.65 0.63 0.77 0.48 0 0 0 0 0 0 0 0 0 0 1 0 1558080_s_at DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 -1.30 -1.03 -1.15 -1.19 1 0 0 0 0 0 0 0 0 1 0 0 201835_s_at PRKAB1 protein kinase, AMP-activated, beta 1 non-catalytic subunit -0.19 -0.23 -0.07 -0.38 0 0 0 0 0 0 0 0 0 0 1 0 202631_s_at APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2-0.57 -0.26 -0.38 -0.40 1 0 0 0 0 0 0 0 0 1 0 0 231779_at IRAK2 interleukin-1 receptor-associated kinase 2 -0.11 -0.02 -0.32 -0.16 1 0 0 0 0 0 0 0 1 0 0 0 231899_at ZC3H12C zinc finger CCCH-type containing 12C -0.22 0.00 -0.38 -0.15 1 0 0 0 0 0 0 0 1 0 0 0 238692_at BTBD11 BTB (POZ) domain containing 11 -0.16 -0.29 -0.31 -0.44 0 0 0 0 0 0 0 0 0 0 0 1 38158_at ESPL1 extra spindle pole bodies homolog 1 (S. cerevisiae) -0.23 -0.18 -0.45 -0.33 1 0 0 0 0 0 0 0 1 0 0 0 1561171_a_at GOLGA6L1 /// GOLGA6L6golgin A6 family-like /// LOC100132025 1 /// golgin A6 family-like 6 /// transmembrane0.49 domain-containing0.42 0.60 protein0.27 ENSP00000320207-like0 0 0 0 0 0 0 0 0 0 1 0 201328_at ETS2 v-ets erythroblastosis virus E26 oncogene homolog 2 (avian) -0.47 -0.38 -0.67 -0.52 1 0 0 0 0 0 0 0 1 0 0 0 201831_s_at USO1 USO1 vesicle docking protein homolog (yeast) -0.25 0.02 0.11 -0.13 0 0 0 0 0 0 1 0 0 0 0 0 202871_at TRAF4 TNF receptor-associated factor 4 0.46 0.54 0.68 0.41 0 0 0 0 0 0 0 0 0 0 1 0 203141_s_at AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.31 -0.17 -0.04 -0.31 0 0 0 0 0 0 1 0 0 0 1 0 208003_s_at NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.31 -0.02 -0.28 -0.16 1 0 0 0 0 0 0 0 0 1 0 0 227952_at ZNF595 zinc finger protein 595 1.27 1.03 1.35 0.88 0 0 0 0 0 0 0 0 0 0 1 1 235815_at TSHZ2 teashirt zinc finger homeobox 2 0.02 0.37 0.17 0.23 1 0 0 0 0 0 0 0 0 1 0 0 238423_at SYTL3 synaptotagmin-like 3 0.06 -0.10 -0.10 -0.24 0 0 0 0 0 0 0 0 0 0 0 1 242352_at NIPBL Nipped-B homolog (Drosophila) -0.19 0.11 0.18 -0.02 1 0 0 0 0 0 1 0 0 1 0 0 244132_x_at ZNF518A Zinc finger protein 518A 0.15 0.44 0.16 0.30 1 0 0 0 0 0 0 0 1 1 0 0 203479_s_at OTUD4 OTU domain containing 4 -0.33 -0.04 0.00 -0.17 1 0 0 0 0 0 1 0 0 1 0 0 206323_x_at OPHN1 oligophrenin 1 0.83 0.76 0.91 0.63 0 0 0 0 0 0 0 0 0 0 1 0 210384_at PRMT2 protein arginine methyltransferase 2 -0.09 0.18 0.16 0.06 1 0 0 0 0 0 0 0 0 1 0 0 214430_at GLA galactosidase, alpha -1.12 -0.86 -1.21 -0.99 1 0 0 0 0 0 0 0 1 0 0 0 230464_at S1PR5 sphingosine-1-phosphate receptor 5 0.41 0.28 0.30 0.14 0 0 0 0 0 0 0 0 0 0 0 1 230821_at ZNF148 zinc finger protein 148 -0.03 0.26 0.12 0.12 1 0 0 0 0 0 0 0 0 1 0 0 241219_at ------0.05 0.27 0.32 0.14 0 0 0 0 0 0 1 0 0 0 0 0 1555367_at ZNF479 zinc finger protein 479 0.53 0.47 0.61 0.34 0 0 0 0 0 0 0 0 0 0 1 0 1555913_at GON4L gon-4-like (C. elegans) 0.10 0.27 0.38 0.15 0 0 0 0 0 0 1 0 0 0 0 0 1562925_at ------0.48 0.29 0.48 0.17 0 0 0 0 0 0 0 0 0 0 1 1 201977_s_at KIAA0141 KIAA0141 -0.24 -0.02 0.03 -0.15 0 0 0 0 0 0 1 0 0 0 0 0 204817_at ESPL1 extra spindle pole bodies homolog 1 (S. cerevisiae) -0.25 -0.18 -0.46 -0.30 1 0 0 0 0 0 0 0 1 0 0 0 210943_s_at LYST lysosomal trafficking regulator -0.44 -0.25 -0.16 -0.37 0 0 0 0 0 0 1 0 0 0 0 0 213957_s_at CEP350 centrosomal protein 350kDa -0.08 0.17 0.29 0.05 0 0 0 0 0 0 1 0 0 0 0 0 230067_at FAM124A Family with sequence similarity 124A 0.06 -0.11 -0.08 -0.23 0 0 0 0 0 0 0 0 0 0 0 1 242982_x_at ITGB8 integrin, beta 8 0.21 0.15 0.34 0.04 0 0 0 0 0 0 0 0 0 0 1 0 1552736_a_at NETO1 neuropilin (NRP) and tolloid (TLL)-like 1 0.44 0.37 0.53 0.26 0 0 0 0 0 0 0 0 0 0 1 0 1557166_at PDCD4 programmed cell death 4 (neoplastic transformation inhibitor) 0.42 0.62 0.70 0.51 0 0 0 0 0 0 1 0 0 0 0 0 1560495_at ------0.34 0.17 0.36 0.06 0 0 0 0 0 0 0 0 0 0 1 1 201708_s_at NIPSNAP1 nipsnap homolog 1 (C. elegans) 0.45 0.41 0.57 0.30 0 0 0 0 0 0 0 0 0 0 1 0 206359_at SOCS3 suppressor of cytokine signaling 3 0.00 -0.18 -0.11 -0.29 0 0 0 0 0 0 0 0 0 0 0 1 212570_at ENDOD1 endonuclease domain containing 1 -0.08 0.16 0.32 0.05 0 0 0 0 0 0 1 0 0 0 0 0 224424_x_at ACTR3BP2 ARP3 actin-related protein 3 homolog B (yeast) pseudogene 2 0.57 0.41 0.61 0.31 0 0 0 0 0 0 0 0 0 0 1 1 231747_at CYSLTR1 cysteinyl leukotriene receptor 1 0.12 0.39 0.36 0.29 1 0 0 0 0 0 0 0 0 1 0 0 235299_at SLC41A2 solute carrier family 41, member 2 -1.55 -1.36 -1.63 -1.48 1 0 0 0 0 0 0 0 1 0 0 0 236696_at SR140 U2-associated SR140 protein 0.02 0.26 0.37 0.15 0 0 0 0 0 0 1 0 0 0 0 0 238546_at SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1 -0.76 -0.92 -0.86 -1.04 0 0 0 0 0 0 0 0 0 0 0 1 238551_at FUT11 fucosyltransferase 11 (alpha (1,3) fucosyltransferase) -0.62 -0.34 -0.47 -0.45 1 0 0 0 0 0 0 0 0 1 0 0 240237_at Clcn3 chloride channel 3 -0.45 -0.20 -0.19 -0.31 0 0 0 0 0 0 1 0 0 0 0 0 1567913_at ------0.71 0.64 0.83 0.53 0 0 0 0 0 0 0 0 0 0 1 0 207509_s_at LAIR2 leukocyte-associated immunoglobulin-like receptor 2 0.50 0.26 0.36 0.16 0 0 0 0 0 0 0 0 0 0 0 1

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208042_at AGGF1 angiogenic factor with G patch and FHA domains 1 -0.15 0.10 0.18 0.00 0 0 0 0 0 0 1 0 0 0 0 0 209629_s_at NXT2 nuclear transport factor 2-like export factor 2 -0.30 -0.11 0.02 -0.21 0 0 0 0 0 0 1 0 0 0 0 0 211565_at SH3GL3 SH3-domain GRB2-like 3 0.65 0.43 0.69 0.33 0 0 0 0 0 0 0 0 0 0 1 1 224425_x_at ACTR3BP2 ARP3 actin-related protein 3 homolog B (yeast) pseudogene 2 0.65 0.50 0.69 0.40 0 0 0 0 0 0 0 0 0 0 1 0 227277_at MTDH metadherin -0.20 0.07 -0.07 -0.03 1 0 0 0 0 0 0 0 0 1 0 0 241966_at MYO5A myosin VA (heavy chain 12, myoxin) -0.73 -0.50 -0.43 -0.61 0 0 0 0 0 0 1 0 0 0 0 0 244154_at DDHD1 DDHD domain containing 1 -0.14 0.13 -0.09 0.03 1 0 0 0 0 0 0 0 0 1 0 0 204159_at CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4) -0.06 0.05 -0.22 -0.04 1 0 0 0 0 0 0 0 1 0 0 0 207731_at TMEM161B transmembrane protein 161B 0.39 0.36 0.53 0.27 0 0 0 0 0 0 0 0 0 0 1 0 208360_s_at ------0.51 0.36 0.57 0.27 0 0 0 0 0 0 0 0 0 0 1 0 220882_at ------0.42 -0.22 -0.54 -0.32 1 0 0 0 0 0 0 0 1 0 0 0 222246_at STXBP3 syntaxin binding protein 3 -0.20 0.07 -0.03 -0.02 1 0 0 0 0 0 0 0 0 1 0 0 224546_at ------0.48 0.33 0.64 0.24 0 0 0 0 0 0 0 0 0 0 1 0 242601_at HEPACAM2 HEPACAM family member 2 0.53 0.48 0.67 0.39 0 0 0 0 0 0 0 0 0 0 1 0 243489_at ------1.13 0.83 1.11 0.75 0 0 0 0 0 0 0 0 0 0 0 1 1560025_at ------0.60 0.47 0.66 0.39 0 0 0 0 0 0 0 0 0 0 1 0 216917_s_at SYCP1 synaptonemal complex protein 1 0.42 0.30 0.59 0.22 1 0 0 0 0 0 0 0 1 0 1 0 219662_at C2orf49 chromosome 2 open reading frame 49 -0.43 -0.19 -0.17 -0.27 0 0 0 0 0 0 1 0 0 0 0 0 222439_s_at THRAP3 thyroid hormone receptor associated protein 3 0.03 0.25 0.32 0.17 0 0 0 0 0 0 1 0 0 0 0 0 227093_at USP36 Ubiquitin specific peptidase 36 0.39 0.18 0.26 0.10 0 0 0 0 0 0 0 0 0 0 0 1 233536_at ASXL3 additional sex combs like 3 (Drosophila) 0.29 0.25 0.44 0.17 0 0 0 0 0 0 0 0 0 0 1 0 233579_at ------0.60 0.41 0.63 0.34 0 0 0 0 0 0 0 0 0 0 1 1 234655_at ------0.38 0.26 0.48 0.19 0 0 0 0 0 0 0 0 0 0 1 0 244612_at ------0.58 0.48 0.74 0.40 0 0 0 0 0 0 0 0 0 0 1 0 201793_x_at SMG7 Smg-7 homolog, nonsense mediated mRNA decay factor (C. elegans)-0.14 0.06 0.15 -0.01 0 0 0 0 0 0 1 0 0 0 0 0 216609_at TXN Thioredoxin -0.80 -0.45 -0.84 -0.51 1 0 0 0 0 0 0 0 1 1 1 1 232792_at TRIM69 tripartite motif-containing 69 -0.77 -0.47 -0.70 -0.54 1 0 0 0 0 0 0 0 0 1 0 0 204700_x_at C1orf107 chromosome 1 open reading frame 107 0.03 0.30 0.20 0.24 1 0 0 0 0 0 0 0 0 1 0 0 211637_x_at IGHA1 /// IGHA2immunoglobulin /// IGHD /// IGHG1 heavy /// constant IGHG3 alpha/// IGHG4 1 /// /// immunoglobulin IGHM /// IGHV3-23 heavy-0.33 /// constant IGHV4-31-0.16 alpha /// 2 -0.05IGHV4-59 (A2m marker)-0.22 /// LOC100126583 /// immunoglobulin0 0 heavy constant0 delta0 /// immunoglobulin0 0 heavy1 constant gamma0 1 (G1m0 marker)0 /// immunoglobulin0 0 heavy constant gamma 3 (G3m marker) /// immunoglobulin heavy constant gamma 4 (G4m marker) /// immunoglobulin heavy constant mu /// immunoglobulin heavy variable 3-23 /// immunoglobulin heavy variable 4-31 /// immunoglobulin heavy variable 4-59 /// hypothetical LOC100126583 214193_s_at C1orf107 chromosome 1 open reading frame 107 0.00 0.29 0.15 0.24 1 0 0 0 0 0 0 0 0 1 0 0 217767_at C3 complement component 3 -1.99 -1.82 -2.15 -1.87 1 0 0 0 0 0 0 0 1 0 1 0 232523_at MEGF10 multiple EGF-like-domains 10 0.45 0.33 0.61 0.27 0 0 0 0 0 0 0 0 0 0 1 0 236029_at FAT3 FAT tumor suppressor homolog 3 (Drosophila) 0.50 0.43 0.64 0.37 0 0 0 0 0 0 0 0 0 0 1 0 1562755_at ------0.87 0.64 0.99 0.59 0 0 0 0 0 0 0 0 0 0 1 1 202124_s_at TRAK2 trafficking protein, kinesin binding 2 -0.54 -0.35 -0.27 -0.40 0 0 0 0 0 0 1 0 0 0 0 0 203751_x_at JUND jun D proto-oncogene -0.28 -0.17 -0.01 -0.22 0 0 0 0 0 0 1 0 0 0 0 0 206715_at TFEC transcription factor EC -1.04 -0.78 -1.12 -0.83 1 0 0 0 0 0 0 0 1 1 1 0 207815_at PF4V1 platelet factor 4 variant 1 0.55 0.86 0.72 0.80 1 0 0 0 0 0 0 0 0 1 0 0 207978_s_at NR4A3 nuclear receptor subfamily 4, group A, member 3 -1.20 -1.33 -1.10 -1.38 0 0 0 0 0 0 0 0 0 0 1 0 240013_at ------0.77 -0.51 -0.86 -0.56 1 0 0 0 0 0 0 0 1 0 1 0 244539_at ------0.24 -0.05 0.12 -0.10 0 0 0 0 0 0 1 0 0 0 0 0 205782_at FGF7 fibroblast growth factor 7 0.75 0.56 0.85 0.52 0 0 0 0 0 0 0 0 0 0 1 0 206269_at GCM1 glial cells missing homolog 1 (Drosophila) -1.11 -0.87 -1.17 -0.91 1 0 0 0 0 0 0 0 1 0 0 0 209716_at CSF1 colony stimulating factor 1 (macrophage) -1.97 -1.67 -1.89 -1.71 1 0 0 0 0 0 0 0 0 1 0 0 215801_at ------0.43 0.23 0.53 0.19 1 0 0 0 0 0 0 0 1 0 1 0 222626_at RBM26 RNA binding motif protein 26 -0.17 0.02 0.15 -0.02 0 0 0 0 0 0 1 0 0 0 0 0 231598_x_at TMEM192 transmembrane protein 192 1.03 0.70 1.01 0.66 1 0 0 0 0 0 0 0 0 1 1 1 239197_s_at EZH1 enhancer of zeste homolog 1 (Drosophila) -0.09 0.07 0.18 0.03 0 0 0 0 0 0 1 0 0 0 0 0 244492_at SLA Src-like-adaptor -0.24 -0.14 -0.40 -0.18 1 0 0 0 0 0 0 0 1 0 0 0 1569664_at LOC375010 ankyrin repeat domain 20 family, member A pseudogene 0.79 0.59 0.91 0.56 0 0 0 0 0 0 0 0 0 0 1 0 201367_s_at ZFP36L2 zinc finger protein 36, C3H type-like 2 0.02 -0.15 0.16 -0.18 0 0 0 0 0 0 0 0 0 0 1 0 203925_at GCLM glutamate-cysteine ligase, modifier subunit -0.78 -0.50 -0.86 -0.53 1 0 0 0 0 0 0 0 1 1 1 0 209210_s_at FERMT2 fermitin family member 2 -1.82 -1.42 -1.90 -1.45 1 0 0 0 0 0 0 0 1 1 1 1 214409_at RFPL3S RFPL3 antisense RNA (non-protein coding) -1.36 -0.98 -1.52 -1.01 1 0 0 0 0 0 0 0 1 1 1 1 229715_at DKFZp686O24166hypothetical protein DKFZp686O24166 -1.11 -0.92 -1.19 -0.95 1 0 0 0 0 0 0 0 1 0 0 0 230302_at ------0.92 -0.65 -1.06 -0.68 1 0 0 0 0 0 0 0 1 1 1 0 240089_at NFE2L3 nuclear factor (erythroid-derived 2)-like 3 -0.90 -0.59 -0.77 -0.62 1 0 0 0 0 0 0 0 0 1 0 1 1553856_s_at P2RY10 purinergic receptor P2Y, G-protein coupled, 10 -0.22 -0.06 0.08 -0.08 0 0 0 0 0 0 1 0 0 0 0 0 1559688_at GRAPL GRB2-related adaptor protein-like 0.55 0.25 0.53 0.23 1 0 0 0 0 0 0 0 1 1 1 1 1561489_at ------0.66 0.52 0.82 0.51 1 0 0 0 0 0 0 0 1 0 1 0 203828_s_at IL32 interleukin 32 0.39 0.51 0.66 0.50 0 0 0 0 0 0 1 0 0 0 0 0 219507_at RSRC1 arginine/serine-rich coiled-coil 1 -0.33 -0.16 -0.04 -0.18 0 0 0 0 0 0 1 0 0 0 0 0 221144_at TMEM131 transmembrane protein 131 0.54 0.39 0.67 0.36 1 0 0 0 0 0 0 0 1 0 1 0 1558982_at LOC375010 ankyrin repeat domain 20 family, member A pseudogene 0.46 0.27 0.57 0.26 0 0 0 0 0 0 0 0 0 0 1 0 202975_s_at RHOBTB3 Rho-related BTB domain containing 3 -0.69 -0.35 -0.54 -0.36 1 0 0 0 0 0 0 0 0 1 0 1 212065_s_at USP34 ubiquitin specific peptidase 34 -0.48 -0.31 -0.15 -0.32 0 0 0 0 0 0 1 0 0 0 0 0 233092_s_at LOC100271840hypothetical LOC100271840 0.56 0.34 0.60 0.33 0 0 0 0 0 0 0 0 0 0 1 0 243386_at CASZ1 castor zinc finger 1 -0.49 -0.26 -0.56 -0.27 1 0 0 0 0 0 0 0 1 0 1 0 202976_s_at RHOBTB3 Rho-related BTB domain containing 3 -0.73 -0.48 -0.78 -0.49 1 0 0 0 0 0 0 0 1 0 1 0 238756_at GAS2L3 Growth arrest-specific 2 like 3 -1.78 -1.57 -1.90 -1.57 0 0 0 0 0 0 0 0 0 0 1 0 202446_s_at PLSCR1 phospholipid scramblase 1 -0.98 -1.27 -1.11 -1.27 1 0 0 0 0 0 0 0 0 1 0 1 209286_at CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3 -0.45 -0.18 -0.45 -0.17 1 0 0 0 0 0 0 0 0 1 1 1 217544_at LOC729806 similar to hCG1725380 -0.64 -0.26 -0.49 -0.26 1 0 0 0 0 0 0 0 0 1 0 1 222249_at ------0.34 0.12 0.39 0.13 1 0 0 0 0 0 0 0 1 0 1 0 228477_at ARGLU1 arginine and glutamate rich 1 -0.27 0.10 -0.10 0.11 1 0 0 0 0 0 0 0 0 1 0 1 1562745_at ------0.31 -0.19 -0.46 -0.16 1 0 0 0 0 0 0 0 1 0 1 0 225054_x_at LOC100499466hypothetical LOC100499466 -0.40 -0.24 -0.10 -0.22 0 0 0 0 0 0 1 0 0 0 0 0 225685_at CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3 -0.45 -0.23 -0.47 -0.21 0 0 0 0 0 0 0 0 0 0 1 0 228983_at ------1.02 -0.78 -1.03 -0.76 0 0 0 0 0 0 0 0 0 0 1 1 205249_at EGR2 early growth response 2 -2.44 -2.15 -2.61 -2.12 1 0 0 0 0 0 0 0 1 0 1 1 221200_at ------1.57 -1.35 -1.63 -1.33 1 0 0 0 0 0 0 0 1 0 1 0 232538_at ------0.73 0.40 0.89 0.43 1 0 0 0 0 0 0 0 1 0 1 1 1561763_at ------0.31 -0.05 -0.15 -0.01 0 0 0 0 0 0 0 0 0 0 0 1 206038_s_at NR2C2 nuclear receptor subfamily 2, group C, member 2 -0.69 -0.43 -0.52 -0.39 0 0 0 0 0 0 0 0 0 0 0 1 216176_at HCRP1 hepatocellular carcinoma-related HCRP1 -0.17 -0.03 -0.26 0.01 0 0 0 0 0 0 0 0 0 0 1 0 228487_s_at Rreb1 ras responsive element binding protein 1 -0.93 -0.66 -0.81 -0.62 1 0 0 0 0 0 0 0 0 1 0 1 230241_at ------0.53 -0.38 -0.65 -0.34 1 0 0 0 0 0 0 0 1 0 1 0 230618_s_at BAT2L2 HLA-B associated transcript 2-like 2 -0.59 -0.14 -0.43 -0.11 1 0 0 0 0 0 0 0 1 1 1 1 237459_at Cdk17 PCTAIRE protein kinase 2 -0.24 0.13 -0.19 0.17 1 0 0 0 0 0 0 0 1 1 1 1 1563348_at RPL15P22 /// RPL15P3ribosomal /// protein RPL15 ///L15 RPL15P7 pseudogene /// RPL15P17 22; ribosomal /// RPL15P18 protein L15 pseudogene-0.30 18;-0.06 ribosomal-0.34 protein-0.01 L15 pseudogene1 17;0 ribosomal0 protein L150 pseudogene0 3; ribosomal0 protein0 L15 pseudogene0 1 7; ribosomal0 protein1 L15 1 204894_s_at AOC3 amine oxidase, copper containing 3 (vascular adhesion protein 1) -0.58 -0.43 -0.66 -0.38 0 0 0 0 0 0 0 0 0 0 1 0 212634_at KIAA0776 KIAA0776 -0.07 0.06 0.20 0.11 0 0 0 0 0 0 1 0 0 0 0 0 216452_at TRPM3 transient receptor potential cation channel, subfamily M, member 0.503 0.30 0.60 0.35 1 0 0 0 0 0 0 0 1 0 0 0 221935_s_at C3orf64 chromosome 3 open reading frame 64 -0.53 -0.34 -0.56 -0.29 0 0 0 0 0 0 0 0 0 0 1 0 228372_at C10orf128 chromosome 10 open reading frame 128 -1.47 -1.29 -1.51 -1.24 0 0 0 0 0 0 0 0 0 0 1 0 1556306_at MLL5 myeloid/lymphoid or mixed-lineage leukemia 5 (trithorax homolog,-0.23 Drosophila)0.01 -0.19 0.08 0 0 0 0 0 0 0 0 0 0 1 1 204072_s_at FRY furry homolog (Drosophila) -0.23 -0.01 -0.34 0.05 0 0 0 0 0 0 0 0 0 0 1 1 209840_s_at LRRN3 leucine rich repeat neuronal 3 0.14 0.43 0.28 0.49 1 0 0 0 0 0 0 0 0 1 0 1 224898_at WDR26 WD repeat domain 26 -0.62 -0.41 -0.50 -0.36 0 0 0 0 0 0 0 0 0 0 0 1 229061_s_at SLC25A13 solute carrier family 25, member 13 (citrin) -0.68 -0.46 -0.57 -0.40 0 0 0 0 0 0 0 0 0 0 0 1 239401_at S1PR1 sphingosine-1-phosphate receptor 1 -0.15 0.05 -0.05 0.11 0 0 0 0 0 0 0 0 0 0 0 1 242836_at Atp1b3 ATPase, Na+/K+ transporting, beta 3 polypeptide -0.89 -0.72 -1.00 -0.66 0 0 0 0 0 0 0 0 0 0 1 0 202211_at ARFGAP3 ADP-ribosylation factor GTPase activating protein 3 -0.65 -0.44 -0.61 -0.37 0 0 0 0 0 0 0 0 0 0 0 1 205092_x_at ZBTB1 zinc finger and BTB domain containing 1 -0.79 -0.47 -0.80 -0.41 1 0 0 0 0 0 0 0 1 1 1 1 208900_s_at TOP1 topoisomerase (DNA) I -0.06 0.05 0.24 0.12 0 0 0 0 0 0 1 0 0 0 0 0 209841_s_at LRRN3 leucine rich repeat neuronal 3 0.11 0.41 0.16 0.48 1 0 0 0 0 0 0 0 0 1 1 1 214684_at MEF2A myocyte enhancer factor 2A -0.75 -0.59 -0.80 -0.52 0 0 0 0 0 0 0 0 0 0 1 0 221740_x_at LOC100506162hypothetical LOC100506162 -0.28 -0.11 0.01 -0.03 0 0 0 0 0 0 1 0 0 0 0 0 229787_s_at Ogt O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl-0.27 0.09 -0.16 0.17 1 transferase)0 0 0 0 0 0 0 0 1 1 1

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236999_at PPWD1 peptidylprolyl isomerase domain and WD repeat containing 1 -0.33 -0.10 -0.18 -0.04 0 0 0 0 0 0 0 0 0 0 0 1 243748_at eif4e3 eukaryotic translation initiation factor 4E family member 3 -0.24 0.01 -0.15 0.08 0 0 0 0 0 0 0 0 0 0 0 1 1557749_at EHBP1L1 EH domain binding protein 1-like 1 -0.54 -0.32 -0.37 -0.25 0 0 0 0 0 0 0 0 0 0 0 1 1558449_at ------0.21 -0.07 0.07 0.01 0 0 0 0 0 0 1 0 0 0 0 0 1559401_a_at znf609 zinc finger protein 609 -0.48 -0.26 -0.40 -0.18 0 0 0 0 0 0 0 0 0 0 0 1 222101_s_at DCHS1 dachsous 1 (Drosophila) -0.04 0.19 -0.13 0.27 1 0 0 0 0 0 0 0 1 0 1 1 228496_s_at CRIM1 Cysteine rich transmembrane BMP regulator 1 (chordin-like) -0.50 -0.34 -0.53 -0.26 0 0 0 0 0 0 0 0 0 0 1 0 228771_at ADRBK2 adrenergic, beta, receptor kinase 2 -0.66 -0.47 -0.63 -0.40 0 0 0 0 0 0 0 0 0 0 0 1 236106_at C17orf67 chromosome 17 open reading frame 67 -0.27 -0.21 -0.42 -0.14 0 0 0 0 0 0 0 0 0 0 1 0 243036_at CCDC30 coiled-coil domain containing 30 -0.73 -0.51 -0.60 -0.42 0 0 0 0 0 0 0 0 0 0 0 1 205884_at ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)-0.29 -0.10 -0.18 -0.01 0 0 0 0 0 0 0 0 0 0 0 1 206695_x_at ZNF43 zinc finger protein 43 -0.26 -0.07 -0.14 0.02 0 0 0 0 0 0 0 0 0 0 0 1 222587_s_at GALNT7 UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-0.39 -0.19 -0.29 7 (GalNAc-T7)-0.11 0 0 0 0 0 0 0 0 0 0 0 1 223898_at ZNF670 zinc finger protein 670 -0.57 -0.39 -0.64 -0.30 0 0 0 0 0 0 0 0 0 0 1 1 227386_s_at TMEM200B transmembrane protein 200B -0.09 0.03 -0.20 0.12 0 0 0 0 0 0 0 0 0 0 1 0 230629_s_at EP400 E1A binding protein p400 -0.15 -0.01 0.12 0.08 0 0 0 0 0 0 1 0 0 0 0 0 230930_at LOC338620 hypothetical protein LOC338620 -0.81 -0.62 -0.85 -0.53 0 0 0 0 0 0 0 0 0 0 1 1 231403_at TRIO triple functional domain (PTPRF interacting) -1.41 -1.18 -1.27 -1.09 0 0 0 0 0 0 0 0 0 0 0 1 234997_x_at ------0.13 0.05 -0.08 0.14 0 0 0 0 0 0 0 0 0 0 0 1 235975_at MTO1 mitochondrial translation optimization 1 homolog (S. cerevisiae) -0.33 -0.26 -0.45 -0.17 0 0 0 0 0 0 0 0 0 0 1 0 244359_s_at LOC401131 hypothetical LOC401131 0.49 0.26 0.59 0.35 1 0 0 0 0 0 0 0 1 0 0 0 1559072_a_at ELFN2 extracellular leucine-rich repeat and fibronectin type III domain containing-0.14 20.03 -0.16 0.14 0 0 0 0 0 0 0 0 0 0 1 1 1569482_at ------0.05 0.20 0.10 0.30 0 0 0 0 0 0 0 0 0 0 0 1 202213_s_at CUL4B cullin 4B -0.38 -0.21 -0.24 -0.10 0 0 0 0 0 0 0 0 0 0 0 1 202438_x_at IDS iduronate 2-sulfatase -0.81 -0.65 -0.65 -0.55 0 0 0 0 0 0 0 0 0 0 0 1 224516_s_at CXXC5 CXXC finger protein 5 -1.41 -1.19 -1.34 -1.09 0 0 0 0 0 0 0 0 0 0 0 1 229765_at ZNF207 zinc finger protein 207 -0.37 -0.16 -0.26 -0.06 0 0 0 0 0 0 0 0 0 0 0 1 231329_at ITPR1 inositol 1,4,5-triphosphate receptor, type 1 -0.23 -0.05 -0.19 0.05 0 0 0 0 0 0 0 0 0 0 0 1 232709_at ------0.43 -0.21 -0.39 -0.11 0 0 0 0 0 0 0 0 0 0 1 1 236254_at VPS13B vacuolar protein sorting 13 homolog B (yeast) -0.34 -0.30 -0.05 -0.20 0 0 0 0 0 0 1 0 0 0 0 0 237841_at c9orf5 chromosome 9 open reading frame 5 -0.36 0.08 -0.21 0.18 1 0 0 0 0 0 0 0 0 1 1 1 239346_at gtf2h3 general transcription factor IIH, polypeptide 3, 34kDa -0.20 -0.07 -0.23 0.04 0 0 0 0 0 0 0 0 0 0 1 0 239948_at NUP153 nucleoporin 153kDa -0.06 0.13 0.01 0.23 0 0 0 0 0 0 0 0 0 0 0 1 240867_at rfx3 regulatory factor X, 3 (influences HLA class II expression) -0.04 0.01 -0.16 0.10 0 0 0 0 0 0 0 0 0 0 1 0 243640_x_at ZNF135 zinc finger protein 135 0.06 0.24 0.18 0.34 0 0 0 0 0 0 0 0 0 0 0 1 1555392_at LOC100128868Testin-related protein TRG 0.09 0.11 -0.03 0.23 0 0 0 0 0 0 0 0 0 0 1 0 1558924_s_at CLIP1 CAP-GLY domain containing linker protein 1 -0.76 -0.62 -0.34 -0.51 0 0 0 0 0 0 1 0 0 0 0 0 1562957_at ------0.30 -0.15 -0.04 -0.04 0 0 0 0 0 0 0 0 0 0 0 1 200841_s_at EPRS glutamyl-prolyl-tRNA synthetase -0.41 -0.25 -0.16 -0.14 0 0 0 0 0 0 0 0 0 0 0 1 204671_s_at ANKRD6 ankyrin repeat domain 6 -0.55 -0.47 -0.65 -0.36 0 0 0 0 0 0 0 0 0 0 1 0 223400_s_at PBRM1 polybromo 1 -0.95 -0.71 -0.79 -0.59 0 0 0 0 0 0 0 0 0 0 0 1 224737_x_at CCAR1 cell division cycle and apoptosis regulator 1 -0.25 -0.14 -0.30 -0.04 0 0 0 0 0 0 0 0 0 0 1 0 228295_at WDR59 WD repeat domain 59 -0.46 -0.30 -0.10 -0.20 0 0 0 0 0 0 1 0 0 0 0 0 238257_at MLLT10 Myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, -0.75Drosophila);-0.60 translocated-0.82 -0.49to, 10 0 0 0 0 0 0 0 0 0 0 1 0 240432_x_at KLF7 Kruppel-like factor 7 (ubiquitous) -0.13 0.02 -0.01 0.14 0 0 0 0 0 0 0 0 0 0 0 1 244703_x_at IPO9 importin 9 -0.52 -0.34 -0.36 -0.23 0 0 0 0 0 0 0 0 0 0 0 1 209829_at FAM65B family with sequence similarity 65, member B 0.01 0.16 0.11 0.28 0 0 0 0 0 0 0 0 0 0 0 1 224484_s_at BRMS1L breast cancer metastasis-suppressor 1-like -0.23 -0.03 -0.10 0.09 0 0 0 0 0 0 0 0 0 0 0 1 229956_at NR2C1 nuclear receptor subfamily 2, group C, member 1 -0.03 0.13 -0.03 0.25 0 0 0 0 0 0 0 0 0 0 1 1 230752_at CBX5 chromobox homolog 5 (HP1 alpha homolog, Drosophila) -0.33 -0.15 -0.18 -0.03 0 0 0 0 0 0 0 0 0 0 0 1 234488_s_at GMCL1 /// GMCL1Lgerm cell-less homolog 1 (Drosophila) /// germ cell-less homolog 1-0.02 (Drosophila)-like0.13 0.07 0.25 0 0 0 0 0 0 0 0 0 0 0 1 237999_at ZDHHC13 zinc finger, DHHC-type containing 13 -0.35 -0.19 -0.20 -0.07 0 0 0 0 0 0 0 0 0 0 0 1 240703_s_at HERC1 hect (homologous to the E6-AP (UBE3A) carboxyl terminus) domain-0.10 and RCC10.03 (CHC1)-like0.19 domain0.15 (RLD) 1 0 0 0 0 0 0 1 0 0 0 0 0 240762_at Hnrnpk /// LOC644063heterogeneous nuclear ribonucleoprotein K; similar to heterogeneous-0.47 nuclear-0.27 ribonucleoprotein-0.41 -0.15 K 0 0 0 0 0 0 0 0 0 0 1 1 242051_at ------0.22 -0.07 -0.31 0.05 0 0 0 0 0 0 0 0 0 0 1 1 242514_at Gna12 guanine nucleotide binding protein (G protein) alpha 12 -1.17 -1.21 -1.38 -1.10 0 0 0 0 0 0 0 0 0 0 1 0 1557895_at FLJ35934 FLJ35934 -0.25 -0.01 -0.08 0.12 0 0 0 0 0 0 0 0 0 0 0 1 1565876_x_at ------0.07 -0.03 -0.19 0.11 0 0 0 0 0 0 0 0 0 0 1 0 206980_s_at FLT3LG fms-related tyrosine kinase 3 ligand 0.16 0.09 0.36 0.22 1 0 0 0 0 0 0 0 1 0 0 0 220148_at ALDH8A1 aldehyde dehydrogenase 8 family, member A1 -0.42 -0.25 -0.47 -0.13 0 0 0 0 0 0 0 0 0 0 1 1 221773_at ELK3 ELK3, ETS-domain protein (SRF accessory protein 2) -0.25 -0.10 -0.18 0.03 0 0 0 0 0 0 0 0 0 0 0 1 226675_s_at MALAT1 metastasis associated lung adenocarcinoma transcript 1 (non-protein0.00 coding)0.11 0.36 0.24 0 0 0 0 0 0 1 0 0 0 0 0 226794_at STXBP5 syntaxin binding protein 5 (tomosyn) -0.47 -0.24 -0.36 -0.11 0 0 0 0 0 0 0 0 0 0 0 1 230056_at BPTF bromodomain PHD finger transcription factor -0.30 -0.19 -0.34 -0.06 0 0 0 0 0 0 0 0 0 0 1 0 230416_at SLC18A2 solute carrier family 18 (vesicular monoamine), member 2 -0.63 -0.50 -0.72 -0.38 0 0 0 0 0 0 0 0 0 0 1 0 230961_at ------0.39 -0.14 -0.35 -0.01 0 0 0 0 0 0 0 0 0 0 1 1 235848_x_at atl2 atlastin GTPase 2 -0.32 -0.17 -0.31 -0.05 0 0 0 0 0 0 0 0 0 0 1 1 239793_at KLC1 kinesin light chain 1 -0.95 -0.75 -0.79 -0.62 0 0 0 0 0 0 0 0 0 0 0 1 240759_at ACAP2 ArfGAP with coiled-coil, ankyrin repeat and PH domains 2 -0.45 -0.39 -0.55 -0.26 0 0 0 0 0 0 0 0 0 0 1 0 241093_at SEPT6 septin 6 -0.25 -0.18 0.06 -0.05 0 0 0 0 0 0 1 0 0 0 0 0 1560071_a_at ACOT13 acyl-CoA thioesterase 13 -0.59 -0.50 -0.67 -0.37 0 0 0 0 0 0 0 0 0 0 1 0 1570192_at ------0.56 -0.36 -0.47 -0.22 0 0 0 0 0 0 0 0 0 0 0 1 207001_x_at TSC22D3 TSC22 domain family, member 3 0.26 0.00 0.27 0.13 1 0 0 0 0 0 0 0 0 1 0 0 208127_s_at SOCS5 suppressor of cytokine signaling 5 -0.39 -0.24 -0.35 -0.10 0 0 0 0 0 0 0 0 0 0 0 1 216100_s_at TOR1AIP1 torsin A interacting protein 1 -0.79 -0.65 -0.64 -0.51 0 0 0 0 0 0 0 0 0 0 0 1 221904_at FAM131A family with sequence similarity 131, member A -0.20 -0.51 -0.37 -0.37 1 0 0 0 0 0 0 0 0 1 0 0 227227_at LRRC37A leucine rich repeat containing 37A -0.24 -0.11 -0.10 0.02 0 0 0 0 0 0 0 0 0 0 0 1 229687_s_at LOC100287017Hypothetical protein LOC100287017 -0.24 -0.05 -0.20 0.09 0 0 0 0 0 0 0 0 0 0 1 1 230175_s_at DCBLD2 Discoidin, CUB and LCCL domain containing 2 -1.37 -1.25 -1.41 -1.11 0 0 0 0 0 0 0 0 0 0 1 0 233955_x_at CXXC5 CXXC finger protein 5 -1.26 -1.11 -1.14 -0.97 0 0 0 0 0 0 0 0 0 0 0 1 235890_at TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.37 -0.10 -0.24 0.04 1 0 0 0 0 0 0 0 0 1 1 1 236072_at ATAD1 ATPase family, AAA domain containing 1 0.08 0.15 0.00 0.29 0 0 0 0 0 0 0 0 0 0 1 0 243329_at Pcgf3 polycomb group ring finger 3 -0.72 -0.53 -0.55 -0.39 0 0 0 0 0 0 0 0 0 0 0 1 243857_at MORF4L2 Mortality factor 4 like 2 -0.08 0.03 0.27 0.17 0 0 0 0 0 0 1 0 0 0 0 0 244187_at APOOL Apolipoprotein O-like 0.06 -0.21 -0.13 -0.07 1 0 0 0 0 0 0 0 0 1 0 0 1553186_x_at RASEF RAS and EF-hand domain containing 0.43 0.27 0.57 0.41 1 0 0 0 0 0 0 0 1 0 0 0 1555068_at WNK1 WNK lysine deficient protein kinase 1 -0.36 -0.23 -0.23 -0.08 0 0 0 0 0 0 0 0 0 0 0 1 1557352_at SQLE squalene epoxidase 0.06 0.23 0.26 0.38 0 0 0 0 0 0 0 0 0 0 0 1 1565566_a_at STX7 syntaxin 7 -0.39 -0.33 -0.45 -0.18 0 0 0 0 0 0 0 0 0 0 1 0 1566491_at ------0.14 0.27 0.16 0.42 0 0 0 0 0 0 0 0 0 0 1 1 1570194_x_at ------0.84 -0.48 -0.69 -0.33 1 0 0 0 0 0 0 0 0 1 1 1 204075_s_at KIAA0562 KIAA0562 -0.28 -0.12 -0.18 0.03 0 0 0 0 0 0 0 0 0 0 0 1 206188_at ZNF623 zinc finger protein 623 -0.17 -0.04 -0.13 0.11 0 0 0 0 0 0 0 0 0 0 0 1 206239_s_at SPINK1 serine peptidase inhibitor, Kazal type 1 -1.26 -0.72 -1.12 -0.57 1 0 0 0 0 0 0 0 0 1 1 1 228242_at N4BP2 NEDD4 binding protein 2 -0.46 -0.32 -0.37 -0.17 0 0 0 0 0 0 0 0 0 0 0 1 229038_at CWF19L1 CWF19-like 1, cell cycle control (S. pombe) -0.68 -0.58 -0.71 -0.43 0 0 0 0 0 0 0 0 0 0 1 0 230479_at ------0.35 -0.13 -0.22 0.03 0 0 0 0 0 0 0 0 0 0 0 1 238595_at ------0.47 -0.35 -0.42 -0.20 0 0 0 0 0 0 0 0 0 0 0 1 240046_at ubn2 ubinuclein 2 -0.10 -0.15 0.16 0.00 1 0 0 0 0 0 0 0 1 0 0 0 240824_at OBFC1 oligonucleotide/oligosaccharide-binding fold containing 1 0.00 0.12 0.08 0.27 0 0 0 0 0 0 0 0 0 0 0 1 241988_x_at SSH2 slingshot homolog 2 (Drosophila) -0.06 0.05 -0.07 0.20 0 0 0 0 0 0 0 0 0 0 1 0 203869_at USP46 ubiquitin specific peptidase 46 -0.44 -0.29 -0.34 -0.14 0 0 0 0 0 0 0 0 0 0 0 1 204449_at PDCL phosducin-like -0.18 -0.08 -0.14 0.08 0 0 0 0 0 0 0 0 0 0 0 1 214012_at ERAP1 endoplasmic reticulum aminopeptidase 1 -0.10 0.09 -0.03 0.24 0 0 0 0 0 0 0 0 0 0 1 1 235167_at LOC100190986hypothetical LOC100190986 -0.73 -0.57 -0.32 -0.41 0 0 0 0 0 0 0 0 0 0 0 1 240892_at ------0.34 -0.22 -0.30 -0.06 0 0 0 0 0 0 0 0 0 0 0 1 242055_at PSMG4 Proteasome (prosome, macropain) assembly chaperone 4 0.09 0.19 0.19 0.36 0 0 0 0 0 0 0 0 0 0 0 1 243233_at RNU6-1 /// RNU6-2RNA, U6 small nuclear 2; RNA, U6 small nuclear 1 -0.27 -0.16 -0.17 0.01 0 0 0 0 0 0 0 0 0 0 0 1 1554339_a_at COG3 component of oligomeric golgi complex 3 -0.54 -0.39 -0.22 -0.21 0 0 0 0 0 0 0 0 0 0 0 1

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1557513_a_at KLC2 kinesin light chain 2 -0.31 -0.20 -0.19 -0.04 0 0 0 0 0 0 0 0 0 0 0 1 200762_at DPYSL2 dihydropyrimidinase-like 2 -0.17 -0.04 -0.14 0.12 0 0 0 0 0 0 0 0 0 0 1 1 204969_s_at RDX radixin -0.78 -0.62 -0.57 -0.44 0 0 0 0 0 0 0 0 0 0 0 1 220076_at ANKH ankylosis, progressive homolog (mouse) -0.10 -0.02 -0.14 0.14 0 0 0 0 0 0 0 0 0 0 1 0 221079_s_at METTL2A /// METTL2Bmethyltransferase like 2A /// methyltransferase like 2B -0.40 -0.28 -0.28 -0.11 0 0 0 0 0 0 0 0 0 0 0 1 239557_at lrrfip2 leucine rich repeat (in FLII) interacting protein 2 -0.21 -0.21 -0.38 -0.04 0 0 0 0 0 0 0 0 0 0 1 0 239655_at PRDM2 similar to zinc finger protein RIZ -0.11 -0.01 0.04 0.16 0 0 0 0 0 0 0 0 0 0 0 1 243511_at ------0.24 -0.19 -0.30 -0.03 0 0 0 0 0 0 0 0 0 0 1 0 207826_s_at ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein-0.69 -0.59 -0.53 -0.41 0 0 0 0 0 0 0 0 0 0 0 1 228156_at ------0.19 -0.10 -0.06 0.09 0 0 0 0 0 0 0 0 0 0 0 1 231913_s_at BRCC3 BRCA1/BRCA2-containing complex, subunit 3 -0.40 -0.25 -0.22 -0.07 0 0 0 0 0 0 0 0 0 0 0 1 233406_at secisbp2l SECIS binding protein 2-like 0.35 0.18 0.51 0.36 1 0 0 0 0 0 0 0 1 0 0 0 235575_at LOC440993 hypothetical LOC440993 -0.51 -0.35 -0.28 -0.18 0 0 0 0 0 0 0 0 0 0 0 1 236268_at SEC22C SEC22 vesicle trafficking protein homolog C (S. cerevisiae) -0.33 -0.21 -0.17 -0.03 0 0 0 0 0 0 0 0 0 0 0 1 243495_s_at ZNF652 zinc finger protein 652 -0.50 -0.38 -0.19 -0.19 0 0 0 0 0 0 0 0 0 0 0 1 1565915_at ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.21 -0.06 0.08 0.13 0 0 0 0 0 0 1 0 0 0 0 1 1570629_at ATF1 activating transcription factor 1 0.00 -0.12 0.18 0.07 1 0 0 0 0 0 0 0 1 0 0 0 215936_s_at KIAA1033 KIAA1033 -0.48 -0.40 -0.19 -0.21 0 0 0 0 0 0 1 0 0 0 0 1 220943_s_at C2orf56 chromosome 2 open reading frame 56 -0.20 -0.11 -0.08 0.08 0 0 0 0 0 0 0 0 0 0 0 1 229318_at ------0.37 -0.40 -0.48 -0.21 0 0 0 0 0 0 0 0 0 0 1 0 232013_at C9orf102 chromosome 9 open reading frame 102 -0.39 -0.24 -0.18 -0.05 0 0 0 0 0 0 0 0 0 0 0 1 1562067_at CERKL ceramide kinase-like -0.32 -0.35 -0.49 -0.15 0 0 0 0 0 0 0 0 0 0 1 0 215212_at ------0.16 -0.09 -0.05 0.11 0 0 0 0 0 0 0 0 0 0 0 1 242384_at CPEB4 cytoplasmic polyadenylation element binding protein 4 -1.55 -1.61 -1.69 -1.41 0 0 0 0 0 0 0 0 0 0 1 0 1557419_a_at ACSL4 Acyl-CoA synthetase long-chain family member 4 -0.78 -0.98 -1.08 -0.77 0 0 0 0 0 0 0 0 0 0 1 0 1559035_a_at ahr aryl hydrocarbon receptor -1.41 -1.26 -1.07 -1.05 0 0 0 0 0 0 0 0 0 0 0 1 1562505_at Stk35 serine/threonine kinase 35 -0.33 -0.22 -0.14 -0.01 0 0 0 0 0 0 0 0 0 0 0 1 1570264_at HMGN1 high-mobility group nucleosome binding domain 1 -0.11 -0.06 0.01 0.16 0 0 0 0 0 0 0 0 0 0 0 1 204638_at ACP5 acid phosphatase 5, tartrate resistant -0.73 -0.64 -0.53 -0.43 0 0 0 0 0 0 0 0 0 0 0 1 223815_at CCDC45 Coiled-coil domain containing 45 -0.31 -0.25 -0.14 -0.04 0 0 0 0 0 0 0 0 0 0 0 1 231152_at INO80D INO80 complex subunit D -0.28 -0.12 -0.06 0.09 0 0 0 0 0 0 0 0 0 0 0 1 243619_at FGFR1OP2 FGFR1 oncogene partner 2 -0.59 -0.52 -0.40 -0.32 0 0 0 0 0 0 0 0 0 0 0 1 1556472_s_at SCML4 sex comb on midleg-like 4 (Drosophila) 0.21 0.30 0.38 0.52 0 0 0 0 0 0 0 0 0 0 0 1 201295_s_at WSB1 WD repeat and SOCS box-containing 1 -0.51 -0.38 -0.15 -0.15 0 0 0 0 0 0 1 0 0 0 0 1 228315_at ZMAT3 zinc finger, matrin-type 3 -0.12 -0.07 0.04 0.16 0 0 0 0 0 0 0 0 0 0 0 1 236808_at FGFR1OP2 FGFR1 oncogene partner 2 -0.48 -0.36 -0.27 -0.13 0 0 0 0 0 0 0 0 0 0 0 1 1562817_at PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -0.01 -0.11 0.17 0.12 1 0 0 0 0 0 0 0 1 0 0 0 1567044_s_at lsm14a LSM14A, SCD6 homolog A (S. cerevisiae) -0.17 -0.12 -0.01 0.11 0 0 0 0 0 0 0 0 0 0 0 1 215201_at REPS1 RALBP1 associated Eps domain containing 1 -0.06 -0.17 -0.20 0.06 0 0 0 0 0 0 0 0 0 0 1 0 229128_s_at ANP32E Acidic (leucine-rich) nuclear phosphoprotein 32 family, member E 0.08 0.23 0.29 0.46 0 0 0 0 0 0 0 0 0 0 0 1 233637_at DCAF8 DDB1 and CUL4 associated factor 8 -0.21 -0.30 -0.35 -0.06 0 0 0 0 0 0 0 0 0 0 1 0 235722_at SYNJ2BP synaptojanin 2 binding protein -0.38 -0.24 -0.02 -0.01 0 0 0 0 0 0 1 0 0 0 0 1 1569225_a_at SCML4 sex comb on midleg-like 4 (Drosophila) 0.22 0.26 0.36 0.50 0 0 0 0 0 0 0 0 0 0 0 1 216094_at WASL Wiskott-Aldrich syndrome-like -0.31 -0.58 -0.46 -0.34 1 0 0 0 0 0 0 0 0 1 0 0 221015_s_at CDADC1 cytidine and dCMP deaminase domain containing 1 0.14 0.00 -0.03 0.24 0 0 0 0 0 0 0 0 0 0 1 0 228697_at HINT3 histidine triad nucleotide binding protein 3 -0.34 -0.23 -0.14 0.01 0 0 0 0 0 0 0 0 0 0 0 1 242472_x_at FNBP4 Formin binding protein 4 0.06 -0.01 -0.08 0.22 0 0 0 0 0 0 0 0 0 0 1 0 1558937_s_at GUSBP3 glucuronidase, beta pseudogene; glucuronidase, beta pseudogene-0.28 1 -0.24 -0.12 0.01 0 0 0 0 0 0 0 0 0 0 0 1 1564248_at NSUN3 NOL1/NOP2/Sun domain family, member 3 0.10 -0.17 -0.01 0.07 1 0 0 0 0 0 0 0 0 1 0 0 217208_s_at DLG1 discs, large homolog 1 (Drosophila) -0.42 -0.41 -0.17 -0.16 0 0 0 0 0 0 0 0 0 0 0 1 232569_at ------0.03 -0.10 0.24 0.15 1 0 0 0 0 0 0 0 1 0 0 0 233034_at RBMS1 RNA binding motif, single stranded interacting protein 1 -0.60 -0.48 -0.33 -0.23 0 0 0 0 0 0 0 0 0 0 0 1 237803_x_at ------0.16 -0.12 0.03 0.13 0 0 0 0 0 0 0 0 0 0 0 1 229116_at CNKSR2 connector enhancer of kinase suppressor of Ras 2 0.10 0.14 0.24 0.40 0 0 0 0 0 0 0 0 0 0 0 1 239164_at rab12 RAB12, member RAS oncogene family -0.47 -0.45 -0.34 -0.19 0 0 0 0 0 0 0 0 0 0 0 1 239243_at ZNF638 zinc finger protein 638 -0.30 -0.41 -0.43 -0.15 0 0 0 0 0 0 0 0 0 0 1 0 242693_at CDK13 cell division cycle 2-like 5 (cholinesterase-related cell division controller)-0.41 -0.32 -0.22 -0.06 0 0 0 0 0 0 0 0 0 0 0 1 203645_s_at CD163 CD163 molecule -0.66 -0.74 -1.18 -1.08 0 0 0 0 0 0 0 0 0 0 0 1 201809_s_at ENG endoglin -1.60 -1.75 -2.09 -2.07 0 0 0 0 0 0 0 0 0 0 0 1 210004_at OLR1 oxidized low density lipoprotein (lectin-like) receptor 1 -2.79 -2.94 -3.36 -3.26 0 0 0 0 0 0 1 0 0 0 0 1 224341_x_at TLR4 toll-like receptor 4 -1.19 -1.34 -1.70 -1.66 0 0 0 0 0 0 0 0 0 0 0 1 208893_s_at DUSP6 dual specificity phosphatase 6 -1.43 -1.56 -1.93 -1.87 0 0 0 0 0 0 0 0 0 0 0 1 204271_s_at EDNRB endothelin receptor type B 0.15 0.04 -0.11 -0.22 0 0 0 0 0 0 0 0 0 0 0 1 210512_s_at VEGFA vascular endothelial growth factor A -3.60 -3.63 -4.03 -3.89 0 0 0 0 0 0 0 0 0 0 0 1 213446_s_at IQGAP1 IQ motif containing GTPase activating protein 1 -0.94 -0.53 -0.47 -0.79 1 0 0 0 0 0 1 0 0 1 1 0 200998_s_at CKAP4 cytoskeleton-associated protein 4 -0.92 -0.94 -1.07 -1.19 0 0 0 0 0 0 0 0 0 0 0 1 206701_x_at EDNRB endothelin receptor type B 0.07 0.01 -0.14 -0.24 0 0 0 0 0 0 0 0 0 0 0 1 207233_s_at MITF microphthalmia-associated transcription factor -1.46 -1.48 -1.87 -1.73 0 0 0 0 0 0 0 0 0 0 0 1 208702_x_at APLP2 amyloid beta (A4) precursor-like protein 2 -1.20 -1.26 -1.47 -1.51 0 0 0 0 0 0 0 0 0 0 0 1 210665_at TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation-0.45 inhibitor)-0.42 -0.74 -0.68 1 0 0 0 0 0 1 0 1 0 0 0 225262_at FOSL2 FOS-like antigen 2 -0.77 -0.92 -1.02 -1.17 0 0 0 0 0 0 0 0 0 0 0 1 238435_at LOC100506661hypothetical LOC100506661 -0.61 -0.32 -0.33 -0.56 1 0 0 0 0 0 1 0 0 1 0 0 1552701_a_at CARD16 caspase recruitment domain family, member 16 0.29 0.14 -0.01 -0.10 0 0 0 0 0 0 1 0 0 0 0 1 203504_s_at ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -2.25 -2.16 -2.57 -2.40 1 0 0 0 0 0 0 0 1 0 0 0 205003_at DOCK4 dedicator of cytokinesis 4 -1.53 -1.62 -1.89 -1.86 0 0 0 0 0 0 1 0 0 0 0 1 209278_s_at TFPI2 tissue factor pathway inhibitor 2 0.49 0.58 0.17 0.34 1 0 0 0 0 0 0 0 1 0 0 0 212473_s_at MICAL2 microtubule associated monoxygenase, calponin and LIM domain -0.19containing-0.15 2 -0.48 -0.39 1 0 0 0 0 0 1 0 1 0 0 0 225842_at PHLDA1 pleckstrin homology-like domain, family A, member 1 -1.30 -1.40 -1.73 -1.64 1 0 0 0 0 0 1 0 1 0 0 1 227484_at SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -1.59 -1.63 -1.76 -1.87 0 0 0 0 0 0 0 0 0 0 0 1 227889_at LPCAT2 lysophosphatidylcholine acyltransferase 2 -1.16 -1.26 -1.42 -1.50 0 0 0 0 0 0 0 0 0 0 0 1 202071_at SDC4 syndecan 4 -0.82 -0.84 -1.15 -1.06 1 0 0 0 0 0 1 0 1 0 0 0 203603_s_at ZEB2 zinc finger E-box binding homeobox 2 -1.08 -1.00 -1.30 -1.23 1 0 0 0 0 0 0 0 1 0 0 0 204526_s_at TBC1D8 TBC1 domain family, member 8 (with GRAM domain) -0.99 -1.09 -1.33 -1.32 0 0 0 0 0 0 1 0 0 0 0 1 205349_at GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class)-0.97 -1.06 -1.29 -1.29 0 0 0 0 0 0 1 0 0 0 0 1 213816_s_at MET met proto-oncogene (hepatocyte growth factor receptor) -0.45 -0.16 -0.27 -0.39 1 0 0 0 0 0 0 0 0 1 0 0 228846_at MXD1 MAX dimerization protein 1 -1.72 -1.77 -2.08 -2.00 0 0 0 0 0 0 1 0 0 0 0 1 241617_x_at uimc1 ubiquitin interaction motif containing 1 0.23 0.34 0.40 0.11 0 0 0 0 0 0 0 0 0 0 1 0 1560060_s_at VPS37C vacuolar protein sorting 37 homolog C (S. cerevisiae) -1.01 -1.06 -1.34 -1.29 1 0 0 0 0 0 1 0 1 0 0 1 200727_s_at ACTR2 ARP2 actin-related protein 2 homolog (yeast) -0.74 -0.42 -0.47 -0.64 1 0 0 0 0 0 0 0 0 1 0 0 203104_at CSF1R colony stimulating factor 1 receptor -1.32 -1.46 -1.76 -1.68 0 0 0 0 0 0 1 0 0 0 0 1 206176_at BMP6 bone morphogenetic protein 6 -0.99 -1.06 -1.25 -1.28 0 0 0 0 0 0 0 0 0 0 0 1 207085_x_at CSF2RA colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage)-1.55 -1.65 -1.84 -1.86 0 0 0 0 0 0 0 0 0 0 0 1 216316_x_at GK /// GK3P glycerol kinase /// glycerol kinase 3 pseudogene -0.92 -1.06 -1.18 -1.28 0 0 0 0 0 0 0 0 0 0 0 1 221210_s_at NPL N-acetylneuraminate pyruvate lyase (dihydrodipicolinate synthase)-2.26 -2.37 -2.55 -2.59 0 0 0 0 0 0 0 0 0 0 0 1 230266_at RAB7B RAB7B, member RAS oncogene family -2.12 -2.17 -2.52 -2.38 0 0 0 0 0 0 0 0 0 0 0 1 200878_at EPAS1 endothelial PAS domain protein 1 -0.84 -0.89 -1.00 -1.10 0 0 0 0 0 0 0 0 0 0 0 1 202252_at RAB13 RAB13, member RAS oncogene family -1.37 -1.47 -1.74 -1.69 0 0 0 0 0 0 1 0 0 0 0 1 202345_s_at FABP5 fatty acid binding protein 5 (psoriasis-associated) -2.12 -2.27 -2.54 -2.49 0 0 0 0 0 0 0 0 0 0 0 1 202375_at SEC24D SEC24 family, member D (S. cerevisiae) -0.66 -0.60 -0.91 -0.81 1 0 0 0 0 0 0 0 1 0 0 0 203833_s_at TGOLN2 trans-golgi network protein 2 -0.84 -0.56 -0.68 -0.77 1 0 0 0 0 0 0 0 0 1 0 0 204324_s_at GOLIM4 golgi integral membrane protein 4 -1.03 -0.70 -0.74 -0.91 1 0 0 0 0 0 1 0 0 1 0 0 204834_at FGL2 fibrinogen-like 2 -0.71 -0.79 -0.86 -0.99 0 0 0 0 0 0 0 0 0 0 0 1 205099_s_at CCR1 chemokine (C-C motif) receptor 1 -2.52 -2.67 -2.95 -2.88 0 0 0 0 0 0 0 0 0 0 0 1 206034_at SERPINB8 serpin peptidase inhibitor, clade B (ovalbumin), member 8 -0.39 -0.41 -0.70 -0.62 1 0 0 0 0 0 1 0 1 0 0 0 209191_at TUBB6 tubulin, beta 6 -1.58 -1.56 -1.88 -1.77 1 0 0 0 0 0 1 0 1 0 0 0 209568_s_at RGL1 ral guanine nucleotide dissociation stimulator-like 1 0.17 0.05 -0.04 -0.16 0 0 0 0 0 0 0 0 0 0 0 1 214696_at C17orf91 chromosome 17 open reading frame 91 -0.78 -0.73 -1.08 -0.94 1 0 0 0 0 0 1 0 1 0 0 0 224374_s_at EMILIN2 elastin microfibril interfacer 2 -0.80 -0.89 -1.06 -1.09 0 0 0 0 0 0 0 0 0 0 0 1 228152_s_at DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.88 -0.97 -1.18 -1.18 0 0 0 0 0 0 0 0 0 0 0 1

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229435_at GLIS3 GLIS family zinc finger 3 -1.64 -1.62 -1.92 -1.82 1 0 0 0 0 0 0 0 1 0 0 0 201952_at ALCAM activated leukocyte cell adhesion molecule -1.67 -1.70 -2.00 -1.90 1 0 0 0 0 0 1 0 1 0 0 0 203921_at CHST2 carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2 0.15 0.01 -0.05 -0.18 0 0 0 0 0 0 0 0 0 0 0 1 204204_at SLC31A2 solute carrier family 31 (copper transporters), member 2 -1.49 -1.43 -1.73 -1.63 1 0 0 0 0 0 0 0 1 0 0 0 204351_at S100P S100 calcium binding protein P -0.71 -0.80 -0.95 -0.99 0 0 0 0 0 0 0 0 0 0 0 1 206011_at CASP1 caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta,0.90 convertase)0.83 0.67 0.63 0 0 0 0 0 0 0 0 0 0 0 1 206522_at MGAM maltase-glucoamylase (alpha-glucosidase) -1.46 -1.57 -1.84 -1.77 0 0 0 0 0 0 0 0 0 0 0 1 218833_at ZAK sterile alpha motif and leucine zipper containing kinase AZK -0.90 -0.99 -1.17 -1.18 0 0 0 0 0 0 0 0 0 0 0 1 219053_s_at VPS37C vacuolar protein sorting 37 homolog C (S. cerevisiae) -1.05 -1.08 -1.34 -1.27 1 0 0 0 0 0 1 0 1 0 0 0 223019_at FAM129B family with sequence similarity 129, member B -1.51 -1.60 -1.92 -1.80 1 0 0 0 0 0 1 0 1 0 0 1 224828_at CPEB4 cytoplasmic polyadenylation element binding protein 4 -1.52 -1.17 -1.20 -1.36 1 0 0 0 0 0 1 0 0 1 0 0 226517_at BCAT1 branched chain amino-acid transaminase 1, cytosolic -1.62 -1.63 -1.91 -1.84 1 0 0 0 0 0 1 0 1 0 0 0 1563745_a_at LOC283050 hypothetical LOC283050 -2.29 -2.29 -2.56 -2.48 1 0 0 0 0 0 1 0 1 0 0 0 201976_s_at MYO10 myosin X -1.08 -1.14 -1.36 -1.33 0 0 0 0 0 0 1 0 0 0 0 0 205685_at CD86 CD86 molecule -1.58 -1.67 -1.70 -1.86 0 0 0 0 0 0 0 0 0 0 0 1 210427_x_at ANXA2 annexin A2 -1.06 -1.14 -1.33 -1.33 0 0 0 0 0 0 1 0 0 0 0 1 213095_x_at AIF1 allograft inflammatory factor 1 -0.61 -0.75 -0.78 -0.94 0 0 0 0 0 0 0 0 0 0 0 1 218035_s_at RBM47 RNA binding motif protein 47 -1.72 -1.60 -1.96 -1.79 1 0 0 0 0 0 0 0 1 0 0 0 223405_at NPL N-acetylneuraminate pyruvate lyase (dihydrodipicolinate synthase)-2.01 -2.12 -2.28 -2.31 0 0 0 0 0 0 0 0 0 0 0 1 1559485_at ATG2B ATG2 autophagy related 2 homolog B (S. cerevisiae) -0.10 0.17 0.06 -0.01 1 0 0 0 0 0 0 0 0 1 0 0 1560492_at CRADD CASP2 and RIPK1 domain containing adaptor with death domain -0.59 -0.71 -0.82 -0.89 0 0 0 0 0 0 0 0 0 0 0 1 203505_at ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -2.02 -1.94 -2.22 -2.12 1 0 0 0 0 0 0 0 1 0 0 0 204359_at FLRT2 fibronectin leucine rich transmembrane protein 2 -2.18 -2.28 -2.39 -2.46 0 0 0 0 0 0 0 0 0 0 0 1 207376_at VENTX VENT homeobox homolog (Xenopus laevis) -0.04 -0.13 -0.28 -0.31 0 0 0 0 0 0 0 0 0 0 0 1 218676_s_at PCTP phosphatidylcholine transfer protein -0.54 -0.64 -0.80 -0.82 0 0 0 0 0 0 0 0 0 0 0 1 219799_s_at DHRS9 dehydrogenase/reductase (SDR family) member 9 -1.38 -1.48 -1.68 -1.66 0 0 0 0 0 0 1 0 0 0 0 1 225116_at HIPK2 homeodomain interacting protein kinase 2 -0.58 -0.69 -0.89 -0.86 0 0 0 0 0 0 1 0 0 0 0 1 227647_at KCNE3 potassium voltage-gated channel, Isk-related family, member 3 -1.53 -1.69 -1.83 -1.87 0 0 0 0 0 0 0 0 0 0 0 1 233888_s_at SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.54 -0.64 -0.69 -0.82 0 0 0 0 0 0 0 0 0 0 0 1 236787_at LOC100507286hypothetical LOC100507286 -1.66 -1.55 -1.83 -1.73 1 0 0 0 0 0 0 0 1 0 0 0 208438_s_at FGR Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog -1.17 -1.06 -1.34 -1.23 1 0 0 0 0 0 0 0 1 0 0 0 212501_at CEBPB CCAAT/enhancer binding protein (C/EBP), beta -1.90 -1.99 -2.24 -2.16 0 0 0 0 0 0 1 0 0 0 0 0 212606_at WDFY3 WD repeat and FYVE domain containing 3 -1.74 -1.86 -1.97 -2.03 0 0 0 0 0 0 0 0 0 0 0 1 214875_x_at APLP2 amyloid beta (A4) precursor-like protein 2 -1.14 -1.23 -1.36 -1.40 0 0 0 0 0 0 0 0 0 0 0 1 218880_at FOSL2 FOS-like antigen 2 -0.83 -0.96 -0.99 -1.13 0 0 0 0 0 0 0 0 0 0 0 1 233506_at ------0.87 -0.66 -0.97 -0.83 1 0 0 0 0 0 0 0 1 0 0 0 1555728_a_at MS4A4A membrane-spanning 4-domains, subfamily A, member 4 -3.21 -3.41 -3.37 -3.57 0 0 0 0 0 0 0 0 0 0 0 1 200782_at ANXA5 annexin A5 -0.96 -0.91 -1.19 -1.07 1 0 0 0 0 0 0 0 1 0 0 0 200999_s_at CKAP4 cytoskeleton-associated protein 4 -0.99 -1.06 -1.28 -1.21 0 0 0 0 0 0 1 0 0 0 0 0 201858_s_at SRGN serglycin -0.64 -0.78 -0.89 -0.94 0 0 0 0 0 0 0 0 0 0 0 1 208426_x_at KIR2DL4 /// KIR2DL5Akiller cell /// immunoglobulin-like LOC100287534 receptor, two domains, long cytoplasmic0.31 tail,0.18 4 /// killer0.18 cell immunoglobulin-like0.02 0 receptor,0 two domains,0 0long cytoplasmic0 tail,0 5A /// killer0 cell immunoglobulin-like0 0 receptor0 2DL4-like0 1 209901_x_at AIF1 allograft inflammatory factor 1 -0.69 -0.92 -0.86 -1.07 0 0 0 0 0 0 0 0 0 0 0 1 210423_s_at SLC11A1 solute carrier family 11 (proton-coupled divalent metal ion transporters),-1.97 member-2.12 1-2.16 -2.28 0 0 0 0 0 0 0 0 0 0 0 1 210872_x_at GAS7 growth arrest-specific 7 -0.18 -0.30 -0.36 -0.46 0 0 0 0 0 0 0 0 0 0 0 1 211532_x_at KIR2DS2 killer cell immunoglobulin-like receptor, two domains, short cytoplasmic0.57 tail,0.38 2 0.48 0.22 0 0 0 0 0 0 0 0 0 0 0 1 216676_x_at KIR3DL3 killer cell immunoglobulin-like receptor, three domains, long cytoplasmic0.48 tail,0.37 3 0.34 0.21 0 0 0 0 0 0 0 0 0 0 0 1 225612_s_at B3GNT5 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5 -1.24 -1.29 -1.52 -1.45 0 0 0 0 0 0 1 0 0 0 0 0 226905_at FAM101B family with sequence similarity 101, member B -0.55 -0.35 -0.65 -0.52 1 0 0 0 0 0 0 0 1 0 0 0 238762_at MTHFD2L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like-0.76 -0.68 -0.94 -0.83 1 0 0 0 0 0 0 0 1 0 0 0 1554390_s_at ACTR2 ARP2 actin-related protein 2 homolog (yeast) -0.84 -0.55 -0.66 -0.70 1 0 0 0 0 0 0 0 0 1 0 0 1554600_s_at LMNA lamin A/C -0.35 -0.50 -0.51 -0.65 0 0 0 0 0 0 0 0 0 0 0 1 204143_s_at ENOSF1 enolase superfamily member 1 -0.85 -0.98 -0.92 -1.13 0 0 0 0 0 0 0 0 0 0 0 1 205896_at SLC22A4 solute carrier family 22 (organic cation/ergothioneine transporter),-1.73 member-1.86 4 -2.03 -2.01 0 0 0 0 0 0 0 0 0 0 0 1 207314_x_at KIR3DL1 /// KIR3DL2killer cell /// immunoglobulin-likeLOC727787 receptor, three domains, long cytoplasmic0.55 tail,0.44 1 /// killer0.47 cell immunoglobulin-like0.29 0 receptor,0 three0 domains,0 long cytoplasmic0 0tail, 2 /// killer0 cell immunoglobulin-like0 0 receptor,0 three0 domains,1 long cytoplasmic tail, 2-like 209393_s_at EIF4E2 eukaryotic translation initiation factor 4E family member 2 -0.25 -0.37 -0.45 -0.53 0 0 0 0 0 0 0 0 0 0 0 1 221840_at PTPRE protein tyrosine phosphatase, receptor type, E -1.23 -1.23 -1.53 -1.38 1 0 0 0 0 0 1 0 1 0 0 0 223551_at PKIB protein kinase (cAMP-dependent, catalytic) inhibitor beta 0.54 0.30 0.38 0.14 0 0 0 0 0 0 0 0 0 0 0 1 227013_at LATS2 LATS, large tumor suppressor, homolog 2 (Drosophila) -0.91 -0.91 -1.18 -1.06 1 0 0 0 0 0 1 0 1 0 0 0 229865_at FNDC3B fibronectin type III domain containing 3B -2.20 -2.09 -2.38 -2.24 1 0 0 0 0 0 0 0 1 0 0 0 235146_at TMCC3 transmembrane and coiled-coil domain family 3 -1.17 -1.33 -1.42 -1.48 0 0 0 0 0 0 0 0 0 0 0 1 203297_s_at JARID2 jumonji, AT rich interactive domain 2 -0.70 -0.80 -0.97 -0.94 0 0 0 0 0 0 1 0 0 0 0 0 203298_s_at JARID2 jumonji, AT rich interactive domain 2 -0.84 -0.93 -1.13 -1.08 0 0 0 0 0 0 1 0 0 0 0 0 208262_x_at MEFV Mediterranean fever 0.60 0.39 0.61 0.25 0 0 0 0 0 0 0 0 0 0 1 1 210904_s_at IL13RA1 interleukin 13 receptor, alpha 1 -0.84 -0.97 -0.92 -1.11 0 0 0 0 0 0 0 0 0 0 0 1 213926_s_at AGFG1 ArfGAP with FG repeats 1 -0.59 -0.32 -0.24 -0.46 1 0 0 0 0 0 1 0 0 1 0 0 224615_x_at HM13 histocompatibility (minor) 13 -0.39 -0.52 -0.52 -0.66 0 0 0 0 0 0 0 0 0 0 0 1 229940_at SETD3 SET domain containing 3 -0.79 -0.87 -1.08 -1.00 0 0 0 0 0 0 1 0 0 0 0 0 235407_at ------1.07 -1.01 -1.30 -1.15 1 0 0 0 0 0 0 0 1 0 0 0 242397_at Olr1 oxidized low density lipoprotein (lectin-like) receptor 1 -2.55 -2.68 -2.75 -2.82 0 0 0 0 0 0 0 0 0 0 0 1 204184_s_at ADRBK2 adrenergic, beta, receptor kinase 2 -0.67 -0.40 -0.54 -0.53 1 0 0 0 0 0 0 0 0 1 0 0 207704_s_at GAS7 growth arrest-specific 7 0.09 -0.07 -0.12 -0.20 0 0 0 0 0 0 0 0 0 0 0 1 210184_at ITGAX integrin, alpha X (complement component 3 receptor 4 subunit) -1.12 -1.13 -1.42 -1.26 1 0 0 0 0 0 1 0 1 0 0 0 213895_at EMP1 epithelial membrane protein 1 -1.75 -1.68 -1.98 -1.81 1 0 0 0 0 0 0 0 1 0 0 0 222651_s_at TRPS1 trichorhinophalangeal syndrome I -0.85 -0.98 -1.08 -1.11 0 0 0 0 0 0 0 0 0 0 0 1 227854_at fancl Fanconi anemia, complementation group L -1.00 -1.17 -1.29 -1.30 0 0 0 0 0 0 1 0 0 0 0 1 242853_at FLJ34208 hypothetical protein LOC401106 -0.69 -0.76 -0.95 -0.90 0 0 0 0 0 0 1 0 0 0 0 0 1555833_a_at IRGQ immunity-related GTPase family, Q -0.45 -0.55 -0.73 -0.67 0 0 0 0 0 0 1 0 0 0 0 0 204542_at ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide-0.69 -0.84 alpha-2,6-sialyltransferase-0.72 -0.96 0 2 0 0 0 0 0 0 0 0 0 0 1 208836_at ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide -0.83 -0.72 -1.01 -0.85 1 0 0 0 0 0 0 0 1 0 0 0 213164_at SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member0.16 3 0.45 0.01 0.33 1 0 0 0 0 0 0 0 1 1 1 0 214007_s_at TWF1 twinfilin, actin-binding protein, homolog 1 (Drosophila) -0.65 -0.38 -0.26 -0.51 1 0 0 0 0 0 1 0 0 1 0 0 224576_at ERGIC1 endoplasmic reticulum-golgi intermediate compartment (ERGIC) 1-0.21 -0.37 -0.22 -0.49 0 0 0 0 0 0 0 0 0 0 1 1 224919_at MRPS6 mitochondrial ribosomal protein S6 -0.04 0.27 -0.08 0.15 1 0 0 0 0 0 0 0 1 1 0 0 226489_at TMCC3 transmembrane and coiled-coil domain family 3 -0.82 -0.97 -1.01 -1.09 0 0 0 0 0 0 0 0 0 0 0 1 1554508_at PIK3AP1 phosphoinositide-3-kinase adaptor protein 1 -1.15 -0.90 -0.86 -1.02 0 0 0 0 0 0 1 0 0 0 0 0 207104_x_at LILRB1 leukocyte immunoglobulin-like receptor, subfamily B (with TM and-0.67 ITIM domains),-0.85 member-0.78 -0.971 0 0 0 0 0 0 0 0 0 0 0 1 215051_x_at AIF1 allograft inflammatory factor 1 -0.60 -0.76 -0.72 -0.88 0 0 0 0 0 0 0 0 0 0 0 1 216907_x_at KIR3DL1 /// KIR3DL2killer cell /// immunoglobulin-likeLOC727787 receptor, three domains, long cytoplasmic0.46 tail,0.27 1 /// killer0.34 cell immunoglobulin-like0.15 0 receptor,0 three0 domains,0 long cytoplasmic0 0tail, 2 /// killer0 cell immunoglobulin-like0 0 receptor,0 three0 domains,1 long cytoplasmic tail, 2-like 219631_at LRP12 low density lipoprotein receptor-related protein 12 -2.01 -1.84 -2.11 -1.95 1 0 0 0 0 0 0 0 1 0 0 0 235458_at HAVCR2 hepatitis A virus cellular receptor 2 -1.31 -1.30 -1.58 -1.42 1 0 0 0 0 0 1 0 1 0 0 0 1557885_at C9orf41 chromosome 9 open reading frame 41 0.20 0.19 0.37 0.09 0 0 0 0 0 0 0 0 0 0 1 0 210340_s_at CSF2RA colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage)-1.66 -1.79 -1.99 -1.89 0 0 0 0 0 0 1 0 0 0 0 0 211397_x_at KIR2DL2 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic0.57 tail,0.40 2 0.44 0.30 0 0 0 0 0 0 0 0 0 0 0 1 212297_at ATP13A3 ATPase type 13A3 -1.08 -1.16 -1.42 -1.26 0 0 0 0 0 0 1 0 0 0 0 0 218368_s_at TNFRSF12A tumor necrosis factor receptor superfamily, member 12A -0.82 -0.68 -0.95 -0.79 1 0 0 0 0 0 0 0 1 0 0 0 223143_s_at AKIRIN2 akirin 2 -0.71 -0.83 -0.63 -0.94 0 0 0 0 0 0 0 0 0 0 1 0 230413_s_at AP1S2 Adaptor-related protein complex 1, sigma 2 subunit -0.88 -0.60 -0.83 -0.70 1 0 0 0 0 0 0 0 0 1 0 0 234196_at tmcc3 transmembrane and coiled-coil domain family 3 -0.93 -1.13 -1.08 -1.23 0 0 0 0 0 0 0 0 0 0 0 1 1559249_at ATXN1 ataxin 1 -0.79 -0.52 -0.66 -0.62 1 0 0 0 0 0 0 0 0 1 0 0 203935_at ACVR1 activin A receptor, type I -0.93 -0.76 -1.09 -0.85 1 0 0 0 0 0 0 0 1 0 0 0 226490_at NHSL1 NHS-like 1 0.09 -0.02 0.20 -0.10 0 0 0 0 0 0 0 0 0 0 1 0 226534_at KITLG KIT ligand 0.58 0.35 0.44 0.27 0 0 0 0 0 0 0 0 0 0 0 1 202794_at INPP1 inositol polyphosphate-1-phosphatase -0.58 -0.66 -0.84 -0.74 0 0 0 0 0 0 1 0 0 0 0 0 205191_at RP2 retinitis pigmentosa 2 (X-linked recessive) -1.09 -0.92 -1.23 -1.00 1 0 0 0 0 0 0 0 1 0 0 0 208997_s_at UCP2 uncoupling protein 2 (mitochondrial, proton carrier) -0.16 -0.19 0.00 -0.26 0 0 0 0 0 0 0 0 0 0 1 0 213979_s_at Ctbp1 C-terminal binding protein 1 -0.22 0.04 -0.13 -0.04 1 0 0 0 0 0 0 0 0 1 0 0 217975_at WBP5 WW domain binding protein 5 -1.46 -1.26 -1.59 -1.34 1 0 0 0 0 0 0 0 1 0 0 0 240137_at tdrd6 tudor domain containing 6 -3.06 -3.32 -3.20 -3.39 0 0 0 0 0 0 0 0 0 0 0 1 208750_s_at ARF1 ADP-ribosylation factor 1 -0.45 -0.58 -0.37 -0.65 0 0 0 0 0 0 0 0 0 0 1 0

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228603_at ACTR3 ARP3 actin-related protein 3 homolog (yeast) -0.46 -0.16 -0.30 -0.23 1 0 0 0 0 0 0 0 0 1 0 0 201040_at GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity-0.11 polypeptide-0.22 0.032 -0.28 0 0 0 0 0 0 0 0 0 0 1 0 212595_s_at DAZAP2 DAZ associated protein 2 -0.26 -0.38 -0.10 -0.44 1 0 0 0 0 0 0 0 1 0 1 0 217137_x_at ------0.70 0.58 0.79 0.52 0 0 0 0 0 0 0 0 0 0 1 0 218506_x_at GLYR1 glyoxylate reductase 1 homolog (Arabidopsis) -0.03 -0.14 -0.29 -0.21 0 0 0 0 0 0 1 0 0 0 0 0 228754_at SLC6A6 solute carrier family 6 (neurotransmitter transporter, taurine), member-0.84 6 -0.64 -0.91 -0.70 1 0 0 0 0 0 0 0 1 0 0 0 238420_at Taok1 TAO kinase 1 -0.54 -0.31 -0.18 -0.37 0 0 0 0 0 0 1 0 0 0 0 0 1553944_at MIA2 melanoma inhibitory activity 2 0.27 0.16 0.39 0.11 0 0 0 0 0 0 0 0 0 0 1 0 212075_s_at CSNK2A1 casein kinase 2, alpha 1 polypeptide -0.35 -0.17 -0.05 -0.22 0 0 0 0 0 0 1 0 0 0 0 0 229010_at CBL Cas-Br-M (murine) ecotropic retroviral transforming sequence -1.14 -0.84 -1.01 -0.89 1 0 0 0 0 0 0 0 0 1 0 0 231038_s_at srebf2 sterol regulatory element binding transcription factor 2 -0.50 -0.14 -0.39 -0.18 1 0 0 0 0 0 0 0 0 1 0 1 201950_x_at CAPZB capping protein (actin filament) muscle Z-line, beta 0.00 -0.07 0.17 -0.11 0 0 0 0 0 0 0 0 0 0 1 0 205552_s_at OAS1 2',5'-oligoadenylate synthetase 1, 40/46kDa -0.46 -0.75 -0.57 -0.79 0 0 0 0 0 0 0 0 0 0 0 1 213382_at MST1 /// MST1P2macrophage /// MST1P9 stimulating 1 (hepatocyte growth factor-like) /// macrophage0.37 stimulating0.18 0.45 1 (hepatocyte0.14 growth1 factor-like)0 pseudogene0 2 ///0 macrophage0 stimulating0 1 (hepatocyte0 0growth factor-like)1 pseudogene0 19 0 213734_at WSB2 WD repeat and SOCS box-containing 2 -0.96 -0.69 -0.92 -0.73 1 0 0 0 0 0 0 0 0 1 0 0 225937_at CUX1 cut-like homeobox 1 -0.98 -0.71 -0.89 -0.76 1 0 0 0 0 0 0 0 0 1 0 0 1557348_at ------0.39 0.24 0.49 0.21 0 0 0 0 0 0 0 0 0 0 1 0 208624_s_at EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 -0.35 -0.20 -0.08 -0.23 0 0 0 0 0 0 1 0 0 0 0 0 214155_s_at LARP4 La ribonucleoprotein domain family, member 4 -0.75 -0.53 -0.81 -0.57 1 0 0 0 0 0 0 0 1 0 0 0 225412_at TMEM87B transmembrane protein 87B -0.17 0.03 0.12 0.00 0 0 0 0 0 0 1 0 0 0 0 0 228365_at CPNE8 copine VIII -0.44 -0.28 -0.57 -0.31 1 0 0 0 0 0 0 0 1 0 1 0 242787_at INCENP inner centromere protein antigens 135/155kDa -0.64 -0.36 -0.51 -0.39 1 0 0 0 0 0 0 0 0 1 0 0 235777_at ANKRD44 ankyrin repeat domain 44 0.90 0.63 0.76 0.61 1 0 0 0 0 0 0 0 0 1 0 1 221561_at SOAT1 sterol O-acyltransferase 1 -2.35 -2.02 -2.25 -2.03 1 0 0 0 0 0 0 0 0 1 0 1 229926_at ------0.77 -0.53 -0.79 -0.53 1 0 0 0 0 0 0 0 1 0 0 0 242701_at TBRG1 transforming growth factor beta regulator 1 -0.22 -0.05 0.06 -0.07 0 0 0 0 0 0 1 0 0 0 0 0 216388_s_at LTB4R leukotriene B4 receptor 0.15 0.05 -0.12 0.05 0 0 0 0 0 0 1 0 0 0 0 0 202923_s_at GCLC glutamate-cysteine ligase, catalytic subunit -0.58 -0.27 -0.50 -0.26 1 0 0 0 0 0 0 0 0 1 0 1 207201_s_at SLC22A1 solute carrier family 22 (organic cation transporter), member 1 0.56 0.93 0.71 0.94 1 0 0 0 0 0 0 0 0 1 0 1 219679_s_at WAC WW domain containing adaptor with coiled-coil -0.46 -0.32 -0.19 -0.32 0 0 0 0 0 0 1 0 0 0 0 0 222330_at PDE3B phosphodiesterase 3B, cGMP-inhibited -0.26 0.03 -0.13 0.04 1 0 0 0 0 0 0 0 0 1 0 1 244532_x_at LOC401131 hypothetical LOC401131 0.56 0.33 0.61 0.34 0 0 0 0 0 0 0 0 0 0 1 0 1565358_at RARA retinoic acid receptor, alpha 0.84 0.46 0.70 0.49 1 0 0 0 0 0 0 0 0 1 0 1 207419_s_at RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding0.07 protein-0.13 Rac2)0.14 -0.12 1 0 0 0 0 0 0 0 1 0 0 0 213741_s_at KPNA1 karyopherin alpha 1 (importin alpha 5) -0.72 -0.43 -0.58 -0.42 1 0 0 0 0 0 0 0 0 1 0 1 222424_s_at NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.18 0.13 -0.01 0.15 1 0 0 0 0 0 0 0 0 1 0 1 236761_at LHFPL3 lipoma HMGIC fusion partner-like 3 0.46 0.29 0.58 0.31 1 0 0 0 0 0 0 0 1 0 1 0 238716_at FAM85A family with sequence similarity 85, member A -0.12 0.05 0.15 0.07 0 0 0 0 0 0 1 0 0 0 0 0 1554873_at CSPP1 centrosome and spindle pole associated protein 1 -0.03 0.06 0.24 0.08 0 0 0 0 0 0 1 0 0 0 0 0 209326_at SLC35A2 solute carrier family 35 (UDP-galactose transporter), member A2 -1.09 -0.86 -1.13 -0.83 1 0 0 0 0 0 0 0 1 0 1 0 214551_s_at CD7 CD7 molecule 0.31 0.16 0.45 0.18 1 0 0 0 0 0 0 0 1 0 1 0 218911_at YEATS4 YEATS domain containing 4 -0.34 -0.06 -0.27 -0.02 1 0 0 0 0 0 0 0 0 1 0 1 223515_s_at COQ3 coenzyme Q3 homolog, methyltransferase (S. cerevisiae) -0.51 -0.32 -0.60 -0.29 1 0 0 0 0 0 0 0 1 0 1 0 225202_at RHOBTB3 Rho-related BTB domain containing 3 -0.71 -0.44 -0.66 -0.41 1 0 0 0 0 0 0 0 0 1 0 1 235360_at PLEKHM3 pleckstrin homology domain containing, family M, member 3 -0.82 -0.62 -0.87 -0.59 0 0 0 0 0 0 0 0 0 0 1 0 242117_at MAP3K3 mitogen-activated protein kinase kinase kinase 3 -0.88 -0.60 -0.79 -0.57 1 0 0 0 0 0 0 0 0 1 0 1 243476_at NF1 neurofibromin 1 -0.73 -0.52 -0.77 -0.49 0 0 0 0 0 0 0 0 0 0 1 0 203491_s_at CEP57 centrosomal protein 57kDa -0.17 -0.02 0.12 0.01 0 0 0 0 0 0 1 0 0 0 0 0 204312_x_at CREB1 cAMP responsive element binding protein 1 -0.38 -0.26 -0.10 -0.22 0 0 0 0 0 0 1 0 0 0 0 0 212794_s_at KIAA1033 KIAA1033 -0.42 -0.26 -0.12 -0.23 0 0 0 0 0 0 1 0 0 0 0 0 214723_x_at ANKRD36 ankyrin repeat domain 36 0.08 0.23 0.40 0.27 0 0 0 0 0 0 1 0 0 0 0 0 229359_at ASXL2 additional sex combs like 2 (Drosophila) -0.60 -0.37 -0.49 -0.33 0 0 0 0 0 0 0 0 0 0 0 1 230628_at EP400 E1A binding protein p400 -0.09 0.06 0.21 0.11 0 0 0 0 0 0 1 0 0 0 0 0 233063_s_at ------0.02 0.10 0.29 0.14 0 0 0 0 0 0 1 0 0 0 0 0 237009_at CD69 CD69 molecule -0.10 0.04 0.17 0.08 0 0 0 0 0 0 1 0 0 0 0 0 237322_at MIAT myocardial infarction associated transcript (non-protein coding) 0.16 0.39 0.31 0.43 0 0 0 0 0 0 0 0 0 0 0 1 241814_at RANBP9 RAN binding protein 9 0.07 0.14 0.34 0.18 0 0 0 0 0 0 1 0 0 0 0 0 244423_at fam107b family with sequence similarity 107, member B -1.17 -0.92 -1.04 -0.88 0 0 0 0 0 0 0 0 0 0 0 1 1555991_s_at C22orf42 chromosome 22 open reading frame 42 0.25 0.36 0.12 0.41 0 0 0 0 0 0 0 0 0 0 1 0 1557049_at BTBD19 BTB (POZ) domain containing 19 -0.83 -0.71 -0.98 -0.65 1 0 0 0 0 0 0 0 1 0 1 0 1569107_s_at ZNF642 zinc finger protein 642 -0.57 -0.33 -0.53 -0.28 0 0 0 0 0 0 0 0 0 0 0 1 200799_at HSPA1A heat shock 70kDa protein 1A -0.58 -0.33 -0.48 -0.28 0 0 0 0 0 0 0 0 0 0 0 1 204170_s_at CKS2 CDC28 protein kinase regulatory subunit 2 0.09 0.32 0.17 0.36 0 0 0 0 0 0 0 0 0 0 0 1 207957_s_at PRKCB protein kinase C, beta -0.47 -0.25 -0.39 -0.20 0 0 0 0 0 0 0 0 0 0 0 1 208536_s_at BCL2L11 BCL2-like 11 (apoptosis facilitator) -0.19 -0.06 0.14 -0.01 0 0 0 0 0 0 1 0 0 0 0 0 225939_at EIF4E3 eukaryotic translation initiation factor 4E family member 3 -0.21 0.05 -0.19 0.10 1 0 0 0 0 0 0 0 0 1 1 1 232065_x_at CENPL centromere protein L -0.24 0.00 -0.20 0.05 0 0 0 0 0 0 0 0 0 0 0 1 202922_at GCLC glutamate-cysteine ligase, catalytic subunit -0.37 -0.16 -0.34 -0.10 0 0 0 0 0 0 0 0 0 0 0 1 208103_s_at ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E -0.27 -0.06 -0.16 0.01 0 0 0 0 0 0 0 0 0 0 0 1 210995_s_at TRIM23 tripartite motif-containing 23 -0.37 -0.22 -0.04 -0.15 0 0 0 0 0 0 1 0 0 0 0 0 213092_x_at DNAJC9 DnaJ (Hsp40) homolog, subfamily C, member 9 -0.30 -0.09 -0.18 -0.04 0 0 0 0 0 0 0 0 0 0 0 1 219073_s_at OSBPL10 oxysterol binding protein-like 10 -0.54 -0.21 -0.43 -0.14 1 0 0 0 0 0 0 0 0 1 1 1 222838_at SLAMF7 SLAM family member 7 0.29 0.52 0.40 0.58 0 0 0 0 0 0 0 0 0 0 0 1 225633_at DPY19L3 dpy-19-like 3 (C. elegans) 0.06 0.29 0.16 0.34 0 0 0 0 0 0 0 0 0 0 0 1 230913_at ------0.46 0.63 0.38 0.69 0 0 0 0 0 0 0 0 0 0 1 0 238890_at BRWD1 bromodomain and WD repeat domain containing 1 -0.36 -0.09 -0.35 -0.03 1 0 0 0 0 0 0 0 0 1 1 1 243740_at ------0.33 -0.12 -0.31 -0.06 0 0 0 0 0 0 0 0 0 0 0 1 244822_at GART phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide-0.17 synthetase,0.08 -0.01 phosphoribosylaminoimidazole0.14 0 0 synthetase0 0 0 0 0 0 0 0 0 1 37433_at PIAS2 protein inhibitor of activated STAT, 2 -0.42 -0.14 -0.33 -0.08 1 0 0 0 0 0 0 0 0 1 0 1 1568680_s_at YTHDC2 YTH domain containing 2 -0.13 0.00 0.15 0.07 0 0 0 0 0 0 1 0 0 0 0 0 201101_s_at BCLAF1 BCL2-associated transcription factor 1 -0.06 0.02 0.21 0.09 0 0 0 0 0 0 1 0 0 0 0 0 204446_s_at ALOX5 arachidonate 5-lipoxygenase -0.95 -0.74 -0.83 -0.67 0 0 0 0 0 0 0 0 0 0 0 1 208859_s_at ATRX alpha thalassemia/mental retardation syndrome X-linked -0.14 0.03 0.16 0.10 0 0 0 0 0 0 1 0 0 0 0 0 209648_x_at SOCS5 suppressor of cytokine signaling 5 -0.33 -0.11 -0.25 -0.04 0 0 0 0 0 0 0 0 0 0 0 1 211968_s_at HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.24 -0.08 0.04 -0.01 0 0 0 0 0 0 1 0 0 0 0 0 224834_at UBTD2 ubiquitin domain containing 2 -0.43 -0.21 -0.32 -0.13 0 0 0 0 0 0 0 0 0 0 0 1 226913_s_at SOX8 SRY (sex determining region Y)-box 8 -0.19 0.10 -0.10 0.17 1 0 0 0 0 0 0 0 0 1 1 1 234986_at GCLM glutamate-cysteine ligase, modifier subunit -0.63 -0.46 -0.73 -0.38 1 0 0 0 0 0 0 0 1 0 1 0 1555920_at CBX3 Chromobox homolog 3 (HP1 gamma homolog, Drosophila) -0.31 -0.06 -0.21 0.02 0 0 0 0 0 0 0 0 0 0 0 1 203213_at CDK1 cyclin-dependent kinase 1 -0.99 -0.84 -1.08 -0.76 0 0 0 0 0 0 0 0 0 0 1 0 212113_at ATXN7L3B ataxin 7-like 3B -0.28 -0.06 -0.14 0.02 0 0 0 0 0 0 0 0 0 0 0 1 218783_at INTS7 integrator complex subunit 7 -0.20 0.02 -0.22 0.10 0 0 0 0 0 0 0 0 0 0 1 1 220459_at MCM3AP-AS MCM3AP antisense RNA (non-protein coding) 0.20 0.44 0.34 0.52 0 0 0 0 0 0 0 0 0 0 0 1 224827_at UBTD2 ubiquitin domain containing 2 -0.29 -0.06 -0.21 0.02 0 0 0 0 0 0 0 0 0 0 0 1 225520_at MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like-0.39 -0.18 -0.32 -0.09 0 0 0 0 0 0 0 0 0 0 0 1 225922_at FNIP2 folliculin interacting protein 2 -1.61 -1.36 -1.47 -1.28 0 0 0 0 0 0 0 0 0 0 0 1 225962_at ZNRF1 zinc and ring finger 1 0.18 0.30 0.11 0.39 0 0 0 0 0 0 0 0 0 0 1 0 227156_at CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family)-0.06 0.12 -0.01 0.20 0 0 0 0 0 0 0 0 0 0 0 1 236140_at GCLM glutamate-cysteine ligase, modifier subunit -0.62 -0.43 -0.70 -0.35 0 0 0 0 0 0 0 0 0 0 1 1 1558972_s_at THEMIS thymocyte selection associated 0.17 0.35 0.25 0.44 0 0 0 0 0 0 0 0 0 0 0 1 205659_at HDAC9 histone deacetylase 9 0.39 0.61 0.48 0.70 0 0 0 0 0 0 0 0 0 0 0 1 212637_s_at WWP1 WW domain containing E3 ubiquitin protein ligase 1 -0.15 0.05 -0.06 0.14 0 0 0 0 0 0 0 0 0 0 0 1 222564_at POGK pogo transposable element with KRAB domain -0.20 -0.05 -0.25 0.03 0 0 0 0 0 0 0 0 0 0 1 0 223588_at THAP2 THAP domain containing, apoptosis associated protein 2 -0.73 -0.48 -0.76 -0.40 1 0 0 0 0 0 0 0 1 0 1 1 224802_at NDFIP2 Nedd4 family interacting protein 2 -0.16 0.01 -0.10 0.10 0 0 0 0 0 0 0 0 0 0 0 1 225619_at SLAIN1 SLAIN motif family, member 1 -0.07 0.12 0.01 0.21 0 0 0 0 0 0 0 0 0 0 0 1 228069_at FAM54A family with sequence similarity 54, member A -0.86 -0.59 -0.79 -0.50 1 0 0 0 0 0 0 0 0 1 1 1 228556_at YTHDC1 YTH domain containing 1 -0.13 0.00 0.24 0.09 0 0 0 0 0 0 1 0 0 0 0 0 229226_at MMS19 MMS19 nucleotide excision repair homolog (S. cerevisiae) -0.19 0.01 -0.17 0.10 0 0 0 0 0 0 0 0 0 0 1 1

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239146_at CLDND1 claudin domain containing 1 -0.24 -0.04 -0.26 0.05 0 0 0 0 0 0 0 0 0 0 1 1 91816_f_at MEX3D mex-3 homolog D (C. elegans) -0.88 -0.84 -1.02 -0.74 0 0 0 0 0 0 0 0 0 0 1 0 1560570_a_at ------0.27 -0.11 -0.24 -0.01 0 0 0 0 0 0 0 0 0 0 0 1 202419_at KDSR 3-ketodihydrosphingosine reductase 0.03 0.20 0.15 0.30 0 0 0 0 0 0 0 0 0 0 0 1 204240_s_at SMC2 structural maintenance of chromosomes 2 -0.09 0.07 0.02 0.18 0 0 0 0 0 0 0 0 0 0 0 1 213373_s_at CASP8 caspase 8, apoptosis-related cysteine peptidase 0.22 0.41 0.26 0.51 0 0 0 0 0 0 0 0 0 0 0 1 213922_at TTBK2 tau tubulin kinase 2 -0.09 0.09 -0.01 0.19 0 0 0 0 0 0 0 0 0 0 0 1 214313_s_at EIF5B Eukaryotic translation initiation factor 5B -0.12 0.08 -0.18 0.18 0 0 0 0 0 0 0 0 0 0 1 1 221290_s_at MUM1 melanoma associated antigen (mutated) 1 -0.29 -0.07 -0.27 0.03 0 0 0 0 0 0 0 0 0 0 1 1 222108_at AMIGO2 adhesion molecule with Ig-like domain 2 0.15 0.39 0.25 0.49 0 0 0 0 0 0 0 0 0 0 0 1 223062_s_at PSAT1 phosphoserine aminotransferase 1 -0.23 -0.10 -0.36 0.01 0 0 0 0 0 0 0 0 0 0 1 0 227295_at IKBIP IKBKB interacting protein -0.03 0.17 0.07 0.27 0 0 0 0 0 0 0 0 0 0 0 1 228084_at PLA2G12A phospholipase A2, group XIIA 0.18 0.37 0.31 0.47 0 0 0 0 0 0 0 0 0 0 0 1 229588_at DNAJC10 DnaJ (Hsp40) homolog, subfamily C, member 10 -0.13 0.02 -0.17 0.11 0 0 0 0 0 0 0 0 0 0 1 0 229809_at POU6F1 POU class 6 homeobox 1 -0.39 -0.30 -0.47 -0.19 0 0 0 0 0 0 0 0 0 0 1 0 230120_s_at PLGLB2 plasminogen-like B2 -0.21 -0.04 -0.15 0.06 0 0 0 0 0 0 0 0 0 0 0 1 230893_at DNAJC21 DnaJ (Hsp40) homolog, subfamily C, member 21 -0.14 0.05 -0.03 0.15 0 0 0 0 0 0 0 0 0 0 0 1 235286_at Cklf chemokine-like factor -0.59 -0.42 -0.58 -0.32 0 0 0 0 0 0 0 0 0 0 0 1 238004_at PGBD2 piggyBac transposable element derived 2 -0.28 -0.08 -0.22 0.02 0 0 0 0 0 0 0 0 0 0 0 1 238315_s_at ZNF567 zinc finger protein 567 -0.29 -0.17 0.01 -0.08 0 0 0 0 0 0 1 0 0 0 0 0 238378_at ------0.34 -0.18 -0.28 -0.07 0 0 0 0 0 0 0 0 0 0 0 1 47560_at LPHN1 latrophilin 1 -0.15 0.03 -0.15 0.13 0 0 0 0 0 0 0 0 0 0 1 1 1558517_s_at LRRC8C leucine rich repeat containing 8 family, member C -0.22 -0.03 -0.08 0.08 0 0 0 0 0 0 0 0 0 0 0 1 1569566_at TBC1D1 TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1 -0.25 0.00 -0.10 0.11 0 0 0 0 0 0 0 0 0 0 0 1 202660_at ITPR2 inositol 1,4,5-triphosphate receptor, type 2 -0.26 -0.09 -0.25 0.02 0 0 0 0 0 0 0 0 0 0 1 1 210461_s_at ABLIM1 actin binding LIM protein 1 -0.40 -0.25 -0.21 -0.14 0 0 0 0 0 0 0 0 0 0 0 1 214848_at YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation-0.49 protein,-0.30 zeta polypeptide-0.42 -0.19 0 0 0 0 0 0 0 0 0 0 0 1 217599_s_at MDFIC MyoD family inhibitor domain containing -0.77 -0.52 -0.62 -0.42 0 0 0 0 0 0 0 0 0 0 0 1 222074_at UROD uroporphyrinogen decarboxylase -0.05 0.03 -0.13 0.14 0 0 0 0 0 0 0 0 0 0 1 0 225066_at PPP2R2D protein phosphatase 2, regulatory subunit B, delta -0.50 -0.25 -0.39 -0.14 0 0 0 0 0 0 0 0 0 0 0 1 226460_at FNIP2 folliculin interacting protein 2 -1.46 -1.24 -1.34 -1.13 0 0 0 0 0 0 0 0 0 0 0 1 228297_at cnn3 calponin 3, acidic 0.11 0.28 0.22 0.39 0 0 0 0 0 0 0 0 0 0 0 1 235122_at HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 -2.18 -1.92 -2.14 -1.81 0 0 0 0 0 0 0 0 0 0 1 1 235363_at ------0.15 -0.01 -0.19 0.10 0 0 0 0 0 0 0 0 0 0 1 0 238341_at LOC100506395hypothetical LOC100506395 -0.46 -0.22 -0.33 -0.11 0 0 0 0 0 0 0 0 0 0 0 1 241370_at LOC286052 hypothetical protein LOC286052 -0.23 -0.02 -0.20 0.09 0 0 0 0 0 0 0 0 0 0 1 1 208661_s_at TTC3 tetratricopeptide repeat domain 3 -0.03 0.10 0.27 0.21 0 0 0 0 0 0 1 0 0 0 0 0 209146_at SC4MOL sterol-C4-methyl oxidase-like -0.02 0.14 0.09 0.26 0 0 0 0 0 0 0 0 0 0 0 1 212386_at TCF4 transcription factor 4 -0.07 0.09 0.07 0.21 0 0 0 0 0 0 0 0 0 0 0 1 218073_s_at TMEM48 transmembrane protein 48 -0.44 -0.28 -0.35 -0.16 0 0 0 0 0 0 0 0 0 0 0 1 218236_s_at PRKD3 protein kinase D3 -0.28 -0.11 -0.19 0.01 0 0 0 0 0 0 0 0 0 0 0 1 218538_s_at MRS2 MRS2 magnesium homeostasis factor homolog (S. cerevisiae) -0.26 -0.07 -0.11 0.05 0 0 0 0 0 0 0 0 0 0 0 1 226287_at CCDC34 coiled-coil domain containing 34 0.15 0.31 0.20 0.43 0 0 0 0 0 0 0 0 0 0 0 1 227177_at CORO2A coronin, actin binding protein, 2A -0.08 0.07 -0.05 0.19 0 0 0 0 0 0 0 0 0 0 0 1 230091_at SRPK2 SFRS protein kinase 2 -0.30 -0.11 -0.28 0.01 0 0 0 0 0 0 0 0 0 0 1 1 234297_at RGS8 /// SDHAP3Regulator of G-protein signaling 8 /// Succinate dehydrogenase complex,-0.15 subunit0.01 A,-0.19 flavoprotein0.13 pseudogene0 3 0 0 0 0 0 0 0 0 0 1 1 236704_at LOC100505971hypothetical LOC100505971 -0.25 -0.09 -0.21 0.03 0 0 0 0 0 0 0 0 0 0 0 1 238695_s_at RAB39B RAB39B, member RAS oncogene family -0.23 -0.04 -0.10 0.07 0 0 0 0 0 0 0 0 0 0 0 1 243675_at ------1.82 -1.59 -1.76 -1.47 0 0 0 0 0 0 0 0 0 0 1 1 1555526_a_at SEPT6 septin 6 0.23 0.21 0.47 0.34 1 0 0 0 0 0 0 0 1 0 0 0 1556332_at ------0.43 -0.32 -0.47 -0.20 0 0 0 0 0 0 0 0 0 0 1 0 1557222_at ------0.17 0.32 0.22 0.45 0 0 0 0 0 0 0 0 0 0 0 1 1570621_at AFF1 AF4/FMR2 family, member 1 -0.64 -0.50 -0.33 -0.37 0 0 0 0 0 0 1 0 0 0 0 1 201151_s_at MBNL1 muscleblind-like (Drosophila) -0.19 -0.03 0.14 0.09 0 0 0 0 0 0 1 0 0 0 0 1 201693_s_at EGR1 early growth response 1 -0.35 -0.13 -0.18 0.00 0 0 0 0 0 0 0 0 0 0 0 1 203401_at PRPS2 phosphoribosyl pyrophosphate synthetase 2 -0.09 0.08 -0.02 0.21 0 0 0 0 0 0 0 0 0 0 0 1 203803_at PCYOX1 prenylcysteine oxidase 1 -0.09 0.08 0.03 0.21 0 0 0 0 0 0 0 0 0 0 0 1 204432_at SOX12 SRY (sex determining region Y)-box 12 0.01 0.20 0.11 0.33 0 0 0 0 0 0 0 0 0 0 0 1 205229_s_at COCH coagulation factor C homolog, cochlin (Limulus polyphemus) -0.23 -0.04 -0.07 0.09 0 0 0 0 0 0 0 0 0 0 0 1 213954_at FAM169A family with sequence similarity 169, member A -0.05 0.11 0.14 0.24 0 0 0 0 0 0 0 0 0 0 0 1 217104_at ST20 suppressor of tumorigenicity 20 -0.71 -0.63 -0.85 -0.50 0 0 0 0 0 0 0 0 0 0 1 0 228658_at MIAT myocardial infarction associated transcript (non-protein coding) 0.37 0.53 0.40 0.66 0 0 0 0 0 0 0 0 0 0 0 1 228955_at LRP8 low density lipoprotein receptor-related protein 8, apolipoprotein-0.15 e receptor-0.01 -0.13 0.12 0 0 0 0 0 0 0 0 0 0 0 1 228990_at SNHG12 small nucleolar RNA host gene 12 (non-protein coding) -0.14 0.04 -0.03 0.17 0 0 0 0 0 0 0 0 0 0 0 1 230252_at LPAR5 lysophosphatidic acid receptor 5 -0.19 -0.05 -0.14 0.08 0 0 0 0 0 0 0 0 0 0 0 1 235102_x_at SNORD3B-2 ///small SNORD3B-1 nucleolar /// RNA, SNORD3C C/D box /// 3B-1;SNORD3D small ///nucleolar SNORD3A RNA, C/D box 3B-2;-0.16 small0.01 nucleolar0.00 RNA, C/D0.13 box 3A; small0 nucleolar0 RNA, C/D0 box 3C;0 small nucleolar0 RNA,0 C/D box0 3D 0 0 0 0 1 237035_at WWOX WW domain containing oxidoreductase 0.23 0.43 0.39 0.57 0 0 0 0 0 0 0 0 0 0 0 1 242887_at KCMF1 potassium channel modulatory factor 1 -0.43 -0.27 -0.25 -0.14 0 0 0 0 0 0 0 0 0 0 0 1 242915_at ZNF682 zinc finger protein 682 0.11 0.25 0.13 0.39 0 0 0 0 0 0 0 0 0 0 0 1 1559125_at C16orf53 Chromosome 16 open reading frame 53 -0.16 -0.01 -0.11 0.14 0 0 0 0 0 0 0 0 0 0 0 1 1562249_at LOC285965 hypothetical LOC285965 0.13 0.30 0.23 0.44 0 0 0 0 0 0 0 0 0 0 0 1 1565544_at RNF141 ring finger protein 141 -0.55 -0.33 -0.54 -0.20 0 0 0 0 0 0 0 0 0 0 1 1 203158_s_at GLS glutaminase -0.68 -0.45 -0.53 -0.31 0 0 0 0 0 0 0 0 0 0 0 1 204040_at RNF144A ring finger protein 144A 0.19 0.32 0.21 0.46 0 0 0 0 0 0 0 0 0 0 0 1 209153_s_at TCF3 transcription factor 3 (E2A immunoglobulin enhancer binding factors-0.19 E12/E47)-0.01 -0.14 0.13 0 0 0 0 0 0 0 0 0 0 1 1 209257_s_at SMC3 structural maintenance of chromosomes 3 0.10 -0.01 0.30 0.13 1 0 0 0 0 0 0 0 1 0 0 0 212538_at DOCK9 dedicator of cytokinesis 9 -0.02 0.11 0.09 0.26 0 0 0 0 0 0 0 0 0 0 0 1 225767_at LOC284801 hypothetical protein LOC284801 0.66 0.81 0.82 0.96 0 0 0 0 0 0 0 0 0 0 0 1 228859_at C4orf21 chromosome 4 open reading frame 21 -0.03 0.14 0.07 0.28 0 0 0 0 0 0 0 0 0 0 0 1 229072_at RAB30 RAB30, member RAS oncogene family -0.22 -0.07 -0.08 0.07 0 0 0 0 0 0 0 0 0 0 0 1 230808_at FNTA farnesyltransferase, CAAX box, alpha -0.39 -0.26 -0.20 -0.12 0 0 0 0 0 0 0 0 0 0 0 1 231941_s_at MUC20 mucin 20, cell surface associated -0.40 -0.27 -0.44 -0.13 0 0 0 0 0 0 0 0 0 0 1 1 235046_at INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -0.16 0.01 -0.11 0.15 0 0 0 0 0 0 0 0 0 0 0 1 236208_at MOCS2 molybdenum cofactor synthesis 2 -0.09 0.05 -0.04 0.19 0 0 0 0 0 0 0 0 0 0 0 1 236215_at FAM164A family with sequence similarity 164, member A -0.20 -0.07 -0.11 0.07 0 0 0 0 0 0 0 0 0 0 0 1 236612_at Sgpp1 sphingosine-1-phosphate phosphatase 1 -0.13 0.03 0.11 0.17 0 0 0 0 0 0 0 0 0 0 0 1 236665_at CCDC18 coiled-coil domain containing 18 -0.63 -0.51 -0.50 -0.37 0 0 0 0 0 0 0 0 0 0 0 1 242292_at NCRNA00246Bnon-protein coding RNA 246B -0.09 0.04 -0.02 0.19 0 0 0 0 0 0 0 0 0 0 0 1 244177_at ing1 inhibitor of growth family, member 1 -0.34 -0.17 -0.27 -0.02 0 0 0 0 0 0 0 0 0 0 0 1 201675_at AKAP1 A kinase (PRKA) anchor protein 1 0.19 0.31 0.29 0.45 0 0 0 0 0 0 0 0 0 0 0 1 205316_at SLC15A2 solute carrier family 15 (H+/peptide transporter), member 2 -0.21 -0.19 -0.32 -0.04 0 0 0 0 0 0 0 0 0 0 1 0 215177_s_at ITGA6 integrin, alpha 6 0.21 0.31 0.55 0.47 0 0 0 0 0 0 1 0 0 0 0 0 225144_at BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase)-0.72 -0.53 -0.68 -0.38 0 0 0 0 0 0 0 0 0 0 1 1 238176_at RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2 -0.46 -0.39 -0.51 -0.24 0 0 0 0 0 0 0 0 0 0 1 0 238604_at ------0.02 0.10 0.06 0.25 0 0 0 0 0 0 0 0 0 0 0 1 241763_s_at FBXO32 F-box protein 32 0.15 0.29 0.31 0.44 0 0 0 0 0 0 0 0 0 0 0 1 242245_at SYDE2 synapse defective 1, Rho GTPase, homolog 2 (C. elegans) 0.19 0.40 0.20 0.55 0 0 0 0 0 0 0 0 0 0 1 1 55872_at ZNF512B zinc finger protein 512B -0.15 0.09 -0.12 0.24 0 0 0 0 0 0 0 0 0 0 1 1 1552398_a_at CLEC12A C-type lectin domain family 12, member A -1.03 -0.88 -1.00 -0.73 0 0 0 0 0 0 0 0 0 0 1 1 1555261_at maeA macrophage erythroblast attacher -0.33 -0.21 -0.15 -0.05 0 0 0 0 0 0 0 0 0 0 0 1 1560798_at NCOA1 nuclear receptor coactivator 1 -0.34 -0.21 -0.46 -0.05 0 0 0 0 0 0 0 0 0 0 1 1 204430_s_at SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member-0.36 5-0.18 -0.29 -0.03 0 0 0 0 0 0 0 0 0 0 1 1 205739_x_at ZNF107 zinc finger protein 107 0.00 0.16 0.09 0.32 0 0 0 0 0 0 0 0 0 0 0 1 207996_s_at C18orf1 chromosome 18 open reading frame 1 0.06 0.19 0.16 0.35 0 0 0 0 0 0 0 0 0 0 0 1 217418_x_at MS4A1 membrane-spanning 4-domains, subfamily A, member 1 -0.26 -0.15 0.04 0.01 0 0 0 0 0 0 1 0 0 0 0 1 229571_at ------0.23 -0.11 -0.06 0.05 0 0 0 0 0 0 0 0 0 0 0 1 242918_at NASP Nuclear autoantigenic sperm protein (histone-binding) 0.13 0.24 0.47 0.41 0 0 0 0 0 0 1 0 0 0 0 1 1565830_at KIAA1731 KIAA1731 -0.43 -0.35 -0.49 -0.18 0 0 0 0 0 0 0 0 0 0 1 0 200800_s_at HSPA1A /// HSPA1Bheat shock 70kDa protein 1A /// heat shock 70kDa protein 1B -0.43 -0.26 -0.28 -0.10 0 0 0 0 0 0 0 0 0 0 0 1

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228167_at KLHL6 kelch-like 6 (Drosophila) -0.24 -0.12 -0.13 0.04 0 0 0 0 0 0 0 0 0 0 0 1 228599_at MS4A1 membrane-spanning 4-domains, subfamily A, member 1 -0.30 -0.12 -0.17 0.05 0 0 0 0 0 0 0 0 0 0 0 1 229256_at PGM2L1 phosphoglucomutase 2-like 1 -0.09 0.12 0.03 0.29 0 0 0 0 0 0 0 0 0 0 0 1 235051_at CCDC50 coiled-coil domain containing 50 -0.15 -0.02 0.13 0.15 0 0 0 0 0 0 1 0 0 0 0 1 237560_at MRPS5 Mitochondrial ribosomal protein S5 -0.47 -0.35 -0.36 -0.19 0 0 0 0 0 0 0 0 0 0 0 1 239644_at ZC3H8 zinc finger CCCH-type containing 8 0.21 0.31 0.27 0.48 0 0 0 0 0 0 0 0 0 0 0 1 243841_at SYNE2 spectrin repeat containing, nuclear envelope 2 -0.24 -0.14 -0.03 0.03 0 0 0 0 0 0 0 0 0 0 0 1 244663_at ------0.18 -0.06 -0.21 0.11 0 0 0 0 0 0 0 0 0 0 1 1 203881_s_at DMD dystrophin 0.28 0.37 0.49 0.55 0 0 0 0 0 0 0 0 0 0 0 1 222292_at CD40 CD40 molecule, TNF receptor superfamily member 5 -0.08 0.01 0.07 0.19 0 0 0 0 0 0 0 0 0 0 0 1 207655_s_at BLNK B-cell linker -0.31 -0.15 -0.12 0.04 0 0 0 0 0 0 0 0 0 0 0 1 209761_s_at SP110 SP110 nuclear body protein 0.35 0.19 0.55 0.38 1 0 0 0 0 0 0 0 1 0 0 0 210356_x_at MS4A1 membrane-spanning 4-domains, subfamily A, member 1 -0.24 -0.14 0.05 0.05 0 0 0 0 0 0 1 0 0 0 0 1 210786_s_at FLI1 Friend leukemia virus integration 1 -0.38 -0.30 -0.15 -0.12 0 0 0 0 0 0 0 0 0 0 0 1 207901_at IL12B interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte0.36 0.43 maturation0.67 factor0.63 2, p40) 0 0 0 0 0 0 0 0 0 0 0 1 212382_at TCF4 transcription factor 4 -0.33 -0.20 -0.04 -0.01 0 0 0 0 0 0 1 0 0 0 0 1 219517_at ELL3 /// SERINC4elongation factor RNA polymerase II-like 3 /// serine incorporator -0.074 -0.01 0.05 0.19 0 0 0 0 0 0 0 0 0 0 0 1 228818_at TPD52 tumor protein D52 -0.16 -0.04 0.03 0.17 0 0 0 0 0 0 0 0 0 0 0 1 233252_s_at STRBP spermatid perinuclear RNA binding protein -0.08 0.01 0.07 0.20 0 0 0 0 0 0 0 0 0 0 0 1 240286_at GPM6B glycoprotein M6B -0.34 -0.28 -0.22 -0.08 0 0 0 0 0 0 0 0 0 0 0 1 219497_s_at BCL11A B-cell CLL/lymphoma 11A (zinc finger protein) -0.10 -0.01 0.07 0.20 0 0 0 0 0 0 0 0 0 0 0 1 241762_at FBXO32 F-box protein 32 0.11 0.24 0.34 0.46 0 0 0 0 0 0 0 0 0 0 0 1 202971_s_at DYRK2 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2 0.01 0.07 0.18 0.28 0 0 0 0 0 0 0 0 0 0 0 1 206693_at IL7 interleukin 7 -0.41 -0.29 -0.20 -0.07 0 0 0 0 0 0 0 0 0 0 0 1 213506_at F2RL1 coagulation factor II (thrombin) receptor-like 1 0.34 0.40 0.50 0.63 0 0 0 0 0 0 0 0 0 0 0 1 239292_at ------0.17 -0.09 -0.01 0.12 0 0 0 0 0 0 0 0 0 0 0 1 242968_at ------0.04 -0.12 -0.20 0.09 0 0 0 0 0 0 0 0 0 0 1 0 212827_at IGHM immunoglobulin heavy constant mu -0.08 -0.03 0.12 0.20 0 0 0 0 0 0 0 0 0 0 0 1 228956_at UGT8 UDP glycosyltransferase 8 0.17 0.04 0.31 0.27 1 0 0 0 0 0 0 0 1 0 0 0 235401_s_at FCRLA Fc receptor-like A -0.19 -0.14 -0.02 0.09 0 0 0 0 0 0 0 0 0 0 0 1 1569599_at SAMSN1 SAM domain, SH3 domain and nuclear localization signals 1 -0.59 -0.68 -0.31 -0.43 1 0 0 0 0 0 0 0 1 0 0 0 201465_s_at JUN jun proto-oncogene -0.36 -0.23 -0.07 0.02 0 0 0 0 0 0 0 0 0 0 0 1 206255_at BLK B lymphoid tyrosine kinase -0.16 -0.14 -0.04 0.11 0 0 0 0 0 0 0 0 0 0 0 1

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