sign in sign up
<<
Home , ABI gene family member 3, Actinin alpha 4, Acyltransferase like 2, ADCY4, Ae binding protein 1, Alport syndrome

BASIC RESEARCH www.jasn.org

The Glomerular Transcriptome and a Predicted –Protein Interaction Network

Liqun He,* Ying Sun,* Minoru Takemoto,* Jenny Norlin,* Karl Tryggvason,* Tore Samuelsson,† and Christer Betsholtz*‡

*Division of Matrix Biology, Department of Medical Biochemistry and Biophysics, and ‡Department of Medicine, Karolinska Institutet, Stockholm, and †Department of Medical Biochemistry, Go¨teborg University, Go¨teborg, Sweden

ABSTRACT To increase our understanding of the molecular composition of the glomerulus, we performed a meta-analysis of available glomerular transcriptional profiles made from mouse and man using five different methodologies. We generated a combined catalogue of glomerulus-enriched that emerged from these different sources and then used this to construct a predicted protein–protein interaction network in the glomerulus (GlomNet). The combined glomerulus-enriched catalogue provides the most comprehensive picture of the molecular composition of the glomerulus currently available, and GlomNet contributes an integrative systems biology approach to the understanding of glomerular signaling networks that operate during development, function, and disease.

J Am Soc Nephrol 19: 260–268, 2008. doi: 10.1681/ASN.2007050588

Many kidney diseases and, importantly, approxi- nins have been shown to be mutated in Alport syn- mately two thirds of all cases of ESRD originate with drome and Pierson congenital nephrotic syndromes, glomerular disease. Most cases of glomerular disease respectively.11,12 Genetic studies in mice have further are caused by systemic disorders (e.g., diabetes, hyper- revealed genes and of importance for glomer- tension, lupus, obesity) for which the molecular ulus development and function, such as podoca- pathogeneses of the glomerular complications are un- lyxin,13 CD2AP,14 NEPH1,15 FAT1,16 forkhead box known. Our understanding of glomerular diseases is C2,17 factor 21 (Pod1),18 protein ty- limited to a few monogenic disorders for which mu- rosine phosphatase type O (GLEPP1) and tations have been identified in genes encoding glo- synaptopodin.19,20 merular proteins, such as components of the glomer- It is possible that some of these genes and pro- ular or the filtration teins are targeted also in the common glomerular slits.1–4 These proteins are specifically, or particularly disorders triggered by systemic disease. It can be strongly, expressed in . Examples include anticipated, however, that the identification of nephrin, which was identified through its in familiar nephrotic syndrome of the Finnish type,5 podocin, which is mutated in steroid-resistant ne- Received May 21, 2007. Accepted August 15, 2007. phrotic syndrome,6 and ␣--4, which is mutated Published online ahead of print. Publication date available at in familial FSGS.7 In addition, in the tran- www.jasn.org. scription factors WT1 and LMX1B, which are ex- M.T.’s current affiliation is Department of Clinical Biology and pressed selectively but not exclusively in podocytes, Medicine, Chiba University, Chuo-ku, Japan. lead to glomerular disorders in the context of more Correspondence: Dr. Christer Betsholtz, Department of Medi- complex syndromes referred to as nail-patella, Denys- cine, Karolinska Institutet, SE 171 77, Stockholm, Sweden. Phone: ϩ46-8-52487960; Fax: ϩ46-8-313445; E-mail: christer. 8–10 Drash, or Frasier syndromes, respectively. Finally, [email protected] glomerular basement membrane and lami- Copyright © 2008 by the American Society of Nephrology

260 ISSN : 1046-6673/1902-260 J Am Soc Nephrol 19: 260–268, 2008 www.jasn.org BASIC RESEARCH additional genes and proteins with glomerulus-specific ex- we predicted a protein–protein interaction network in the pression will contribute further important information glomerulus (GlomNet). We propose that the updated cata- about glomerulus development, function, and disease. Im- logue of glomerular transcripts together with GlomNet will portantly, the identification of larger pathways and net- facilitate the search for new genes/proteins and molecular works of genes and proteins in the glomerulus would most pathways operating in glomerular assembly, physiology, likely facilitate the analysis of glomerular disease progres- and pathology. sion and help to unravel mechanisms operating in the com- mon glomerular diseases of systemic origin. So far, a few RESULTS efforts to map transcriptional profiles in glomeruli have been reported, each being successful in identifying limited Glomerulus-Enriched Gene Catalogue subsets of glomerular markers but each also suffering from We summarized and combined the results from five different limitations in scale and technology.17,21–23 Our own two expression-profiling platforms (Tables 1 and 2), four of which previous studies were based on large-scale sequencing of were previously published. These data sets include a mouse mouse glomerulus expressed sequence tag (EST) libraries. kidney EST library comparison,21 a mouse “GlomChip” cDNA By comparing mouse glomerulus EST libraries with whole- microarray profiling,17 a SAGE profiling,23 a human kidney EST libraries, we found almost 500 glomerulus-en- Stanford cDNA microarray profiling,22 and a newly added riched genes.21 We also used mouse glomerulus cDNA mi- mouse Affymetrix Genome 430 2.0 Array profiling. croarrays (GlomChip) to identify approximately 300 Our own two previous studies compared glomerulus-enriched genes.17 In two other large-scale tran- profiles in glomerulus with whole kidney or nonglomerular scriptional profiling studies, human glomeruli and other kidney tissue.17,21 In the EST analysis,21 497 mouse UniGene nephron segments were microdissected and analyzed by clusters identified as glomerulus-enriched were mapped to 373 cDNA microarray technology,22 or serial analysis of gene homologous human genes (NCIB Entrez Gene data- expression (SAGE).23 base, http://www.ncbi.nlm.nih.gov/sites/entrez?cmdϭsearch As a result of the incomplete and only partially overlap- &dbϭgene). From the GlomChip profiling,17 357 mouse genes ping information derived from different species and differ- identified as glomerulus-enriched were mapped to 326 homol- ent technical platforms, genome-scan and glomerulus dis- ogous human Entrez genes. ease gene-hunting projects suffer from the lack of a The SAGE profiling of human kidney identified 229 tags comprehensive source of basic information about the glo- with higher levels in the glomerulus than in three other merular transcriptome. To facilitate the search for new nephron portions.23 They were mapped to 153 human Entrez causes of monogenic glomerular disorders and to help iden- genes. tify molecular pathways and networks involved in the The Stanford cDNA microarray analysis of human kid- pathogenesis of common glomerular diseases, we combined ney identified 196 cDNA clones that were predominantly published and newly produced data in a meta-analysis of the expressed in the glomerulus compared with other parts of glomerular transcriptome. On the basis of this analysis and the nephron.22 They were mapped to 102 human Entrez with the aid of other available data and bioinformatics tools, genes.

Table 1. Summary of the characteristics of the five methodsa Total Glomerulus- Method Species Features on Enriched Genes Selection Criteria the Platform Reported EST libraries Mouse 13,368 EST 497 P Ͻ 0.05, more than three-fold comparison difference with whole kidney tissue GlomChip profiling Mouse 18,496 probes 357 P Ͻ 0.05, more than two-fold difference with nonglomerular kidney tissue Affymetrix profiling Mouse 45,101 probes 1013 P Ͻ 0.05, more than two-fold difference with nonglomerular kidney tissue SAGE profiling Human ϳ50,000 tags 153 P Ͻ 0.01, seven-fold or more difference with at least three nephron libraries Stanford cDNA Human 41,859 probes 102 Cluster analysis, genes predominantly microarray expressed in glomeruli than others profiling aSpecies column shows the RNA sample source for the methods. For each method, total features on the platforms, number of genes identified (mouse/human), and the selection criteria for glomerulus-enriched genes are listed.

J Am Soc Nephrol 19: 260–268, 2008 Systems Biology of the Glomerulus 261 BASIC RESEARCH www.jasn.org

Table 2. Summary of the statistics of the five methodsa Glomerulus-Enriched Literature HPA Confirmed Method Gene (Human) Confirmed (n [%]) (n [%]) EST libraries Comparison 373 73 (19.6) 17 (4.6) GlomChip profiling 326 63 (19.3) 19 (5.8) Affymetrix profiling 914 84 (9.2) 32 (3.5) SAGE profiling 153 37 (24.2) 12 (7.8) Stanford cDNA microarray profiling 102 16 (15.7) 3 (2.9) aThe numbers of glomerulus-enriched genes were counted as human Entrez genes or corresponding human homologous genes. Numbers of literature- and HPA-confirmed genes were also counted. The percentages in the parentheses show the percentage of the corresponding number among the total gene number.

We also compared the gene expression profile of mouse genes thus showed surprisingly limited overlap. Also, each ap- glomeruli with nonglomerulus kidney tissue on Affymetrix proach identified a unique set of genes that were not identified by Mouse Genome 430 2.0 Arrays. Pure preparations of glomeruli any of the other methods. were isolated from newborn mice as described previously.17 A For assessment of the efficiency of each method in identify- total of 1013 mouse genes were identified as more than two- ing glomerulus-enriched genes, the data sets were compared fold upregulated in the glomerulus, which were mapped to 914 with published data on gene or protein expression in glomeruli homologous human Entrez genes. by immunohistochemistry or in situ hybridization (see the In total, 1407 genes were identified as glomerulus-enriched “Literature-Confirmed” column in Supplementary Table S1). in comparison with other parts of the kidney by at least one As shown in Table 2, the highest proportion of literature-con- approach. The genes are listed in Supplementary Table S1 firmed glomerulus-expressed genes/proteins was found in the along with information on the approach by which they were group of genes predicted by SAGE; 37 (24.2%) of 153 identi- identified. fied genes were confirmed. The EST data were 19.6%, Glom- Chip 19.3%, Stanford 15.7%, and Affymetrix 9.2% literature- Comparison and Evaluation of Different Approaches confirmed, respectively. A comparison between the results of the five different approaches The results of the different transcript profiling experiments to identify glomerulus-enriched genes is illustrated in Figure 1. In were also compared with the public Human Protein Atlas total, 1407 genes were identified by at least one approach, and only (HPA) database, as described previously.21,24 The current re- seven genes (CDKN1C, ENG, EMCN, PTPRO, PLAT, IGFBP5, lease (version 2.0; http://www.proteinatlas.org) contains ex- and PPAP2B) were identified in all studies. Of these, CDKN1C, pression data for approximately 1500 in a variety of PTPRO, and PLAT are expressed in podocytes, ENG and EMCN normal and cancerous human tissues. On the basis of the pub- in endothelial cells, and IGFBP5 in mesangial cells. The cellular lished stainings of kidney sections, the protein expression level localization of PPAP2B in the glomerulus has not been reported. in glomerular and tubular cells was assessed semiquantita- The five different approaches to identify glomerulus-enriched tively. The result of protein expression comparison with the HPA database is shown in Table 2. The SAGE analysis showed the highest proportion of HPA-confirmed glomerulus-en- riched proteins (12 [7.8%] of 153 genes confirmed). The re- sults from GlomChip, EST, Affymetrix, and Stanford profil- ings were 5.8, 4.6, 3.5, and 2.9%, respectively (the identity of the HPA-confirmed genes is provided in Supplementary Table S1). Obviously, the Affymetrix analysis, which assesses the ex- pression of almost all genes, identified the largest number of glomerular markers validated by any of the other transcript profiling or by in situ RNA/protein detection (Figure 1, Table 2); however, Affymetrix profiling also identifies the largest to- tal number of “unique” glomerulus-enriched transcripts. The proportion of unique genes (626 [approximately 68%] of 914) was also significantly higher in the Affymetrix analysis than in the other analyses except EST profiling (252 [approximately Figure 1. Venn diagrams showing the overlap among the five 67%] of 373). The proportion of genes identified by one glomerulus-enriched gene list identified by five different meth- method that was validated by at least one other method varied ods. between 32% (Affymetrix) and 73% (GlomChip; Figure 1).

262 Journal of the American Society of Nephrology J Am Soc Nephrol 19: 260–268, 2008 www.jasn.org BASIC RESEARCH

Construction of GlomNet ICAM2, and others), whereas many of the downregulated The Human Protein Reference Database (HPRD; http://ww- genes are expressed specifically in podocytes (NPHS1, PTPRO, w.hprd.org/) contains manually curated protein–protein in- PODXL, CDKN1C, TCF21, WT1, VEGFA, COL4A3, teraction data from published literature. The data have been COL4A4, and others). used to assemble the human protein “interactome.”25 Cur- rently, 36,609 protein–protein interactions are depicted in HPRD (release 6). Among them, we found 772 direct interac- DISCUSSION tions between 543 of the 1407 glomerulus-enriched gene prod- ucts identified by any of the profiling methods (Supplementary Several different techniques for high-throughput and genome- Table S2). These include widely known glomerular protein in- wide analyses of transcriptomes are now available. New tech- teraction pairs, such as NPHS1–NPHS226 and NPHS1–FYN,27 nologies have also been developed for the isolation of cells and as well as numerous other interaction pairs that are less well tissues and for the amplification of RNA from minute amounts studied in the glomerulus. An assembly of the 772 interactions of starting material such that complex transcriptional infor- into a network—GlomNet—is illustrated in Figure 2A (a fully mation can be obtained even from very limited numbers of labeled network for zooming-in exploration is available as cells. The kidney glomerulus is a structure from which tran- Supplementary Figure S1). Known genes whose mutation scriptome information might be particularly useful because causes glomerular abnormality in or mice are high- this structure is severely afflicted by several common systemic lighted within GlomNet in Figure 2A. This figure also illus- disorders, such as diabetes and hypertension. Unfortunately, trates that known glomerular disease proteins are located the molecular pathogeneses of such common glomerular dis- mainly in the extracellular, plasma membrane, and nuclear eases are unknown and treatment possibilities are limited. compartments. There is therefore an urgent need for new information and As an example of a putative signaling network, we depicted insights into the molecular composition and function of the nephrin (NPHS1) and its first, second, and third neighbors in glomerular cells and the identification of pathogenic pathways GlomNet (Figure 2B). By direct or indirect interactions with and, potentially, new glomerular drug targets. no more than two intermediate proteins, nephrin is predicted A few studies have already been published on the glomeru- to contact 128 of the 543 proteins in GlomNet, present in ex- lar transcriptome; however, these studies are difficult to com- tracellular, plasma membrane, , and nuclear com- pare and evaluate directly as a result of differences in techno- partments. It is interesting that at least four of these (PDGFB, logical platforms, species, and glomerulus isolation PDGFRB, VEGFA, and KDR) have already been shown to be techniques. This study was done to facilitate comparison and essential for glomerular development.28–30 to merge available glomerular transcriptome data into a single We also used the glomerulus-enriched gene catalogue and catalogue. By such meta-analysis of published and novel data GlomNet to explore a published set of gene expression changes from two different species—mouse and human—we pro- observed in human glomeruli isolated from patients with dia- duced the most comprehensive map of the glomerular tran- betic nephropathy (DN) in comparison with normal control scriptome available. subjects.31 This study identified 71 upregulated and 378 down- EST sequencing and SAGE are direct ways to sample tran- regulated genes in the DN glomeruli. Twenty-five of the 71 scriptional information. Because significant differences in upregulated genes and 129 of the 378 downregulated genes abundance require several EST/SAGE tags to be sequenced, the were found in the 1407 glomerulus-enriched gene catalogue glomerulus-enriched transcripts identified by EST and SAGE (Supplementary Tables S3 and S4). Given that there are 25,000 approaches are likely also glomerulus-abundant transcripts. As to 30,000 genes in the mammalian genome, of which the DN- such, they would also be predicted to be relatively easier to regulated genes (71 ϩ 378 ϭ 449) represent approximately detect by other experiment methods, such as in situ hybridiza- 1.8% (449 of 25,000), the proportion of DN-regulated genes tion or immunohistochemistry. This prediction partially present in the 1407 glomerulus-enriched gene catalogue is sig- agreed with the result from the literature and HPA, in which a nificantly higher ([25 ϩ 129]/1407 ϭ 10.9%). An even higher higher proportion of SAGE and EST hits were confirmed than proportion of the DN-regulated genes are represented in by the other methods (Table 2). GlomNet (16 upregulated and 70 downregulated; [16 ϩ 70]/ Affymetrix, GlomChip, and the Stanford cDNA all are 543 ϭ 15.8%; Figure 3A). The abundance of DN-affected genes different-sized microarray platforms that use customized in the 1407 catalogue and GlomNet lends support to our pro- methods to normalize and process the raw data, which can posal that these tools may be of particular use in the search for produce differences in the results. Affymetrix and Stanford glomerular pathomechanisms. It is interesting that several of arrays are near genome-wide, whereas GlomChip carries the DN-affected genes link directly to each other in GlomNet, approximately 6000 genes isolated from glomerular cDNA suggesting specific pathways that may be targeted by or be part libraries.17 The Affymetrix platform identified a higher of the pathogenic disease process (Figure 3B). It is interesting number of glomerulus-enriched genes and also more liter- to note that many of the upregulated genes are expressed in ature- and HPA-confirmed genes than any of the other endothelial cells (NOTCH4, TIE1, TEK [TIE2], ENG, PTPRB, methods (Table 2); however, the proportion of the Af-

J Am Soc Nephrol 19: 260–268, 2008 Systems Biology of the Glomerulus 263 BASIC RESEARCH www.jasn.org

Figure 2. (A) Protein–protein interaction network for glomerulus-enriched genes (GlomNet). Proteins are represented with blue nodes, and interactions are represented with edges. The known glomerulus disease genes and the seven genes identified by all five methods are highlighted with deep blue color. (B) Protein–protein interaction network for Nephrin (NPHS1). The proteins directed interact with NPHS1, and the interactions are marked in red.

264 Journal of the American Society of Nephrology J Am Soc Nephrol 19: 260–268, 2008 www.jasn.org BASIC RESEARCH

Figure 3. (A) Gene expression pattern of DN-regulated genes over GlomNet. Red color indicates that the gene was upregulated in the DN glomeruli, and green color indicates that the gene was downregulated. (B) Illustration of DN-regulated genes over GlomNet. This is simplified from A, only showing the DN-regulated genes over GlomNet.

J Am Soc Nephrol 19: 260–268, 2008 Systems Biology of the Glomerulus 265 BASIC RESEARCH www.jasn.org fymetrix glomerulus-enriched genes that were confirmed by Net will be particularly useful to predict links between pre- literature or HPA was lower than for the other methods. viously uncharacterized glomerular proteins and known One explanation for this is that the Affymetrix array is more glomerular disease proteins. As an example of the current sensitive than the other methods and that many of the and future utility of GlomNet, we superimposed data from a “unique” Affymetrix hits likely represent genes with expres- recent glomerular transcription profiling study of DN.31 sion levels undetectable by the other methods. This analysis revealed interesting links between proteins af- A comparison between the results from the two cDNA mi- fected in DN, pinpointing signaling pathways in both endo- croarray approaches, GlomChip and Stanford, shows that thelial cells and podocytes that are differentially up- or GlomChip identified more glomerulus-enriched genes and downregulated. One of the downregulated transcripts in both a higher number and proportion of genes confirmed by DN was Nephrin, which encodes a major component of the literature and HPA. This suggests that for the application to a podocyte diaphragm and is mutated in congenital ne- specific tissue, a corresponding tissue-specific cDNA microar- phrotic syndrome.5 GlomNet illustrates that FYN, which ray might be preferable to a nonspecific cDNA microarray. directly interacts with Nephrin,27 together with three other A comparison among the results of the five different tran- proteins that interact with FYN, namely CD55, CBLB, and scription-profiling approaches (Figure 1) resulted in a surpris- TYRO3, all are downregulated in DN, putatively pinpoint- ingly limited overlap, which may be caused by the different ing a pathway targeted in DN pathogenesis. Other tran- species (mouse and human) and developmental stages (adult scripts that proteins reported to interact with Neph- and newborn) studied. The kidney glomerulus is likely also a rin, such as Podocin (NPHS2) and KIRREL/NEPH1,32,33 target of immune-, stress-, and other environment-induced were not found to be affected in this study of DN. responses that may have varied between the studies. Conceiv- Microarray analyses have been applied to renal disease ably, however, most of the transcriptional differences reflect situations, and an increased focus on the glomerulus is ex- the usage of different technical platforms and protocols. Raw pected along with methodologic improvements for glomer- data were also processed using different methods, and different ular isolation and comprehensive profiling of small biologic criteria were used to categorize genes as glomerulus-enriched. samples; however, deciphering the molecular mechanism Platform-specific features, however, would make it inappro- from the large collections of transcriptome data is neverthe- priate to apply uniform criteria. less challenging. GlomNet is a backbone and blueprint for Conversely, the substantial number of “unique” genes, protein networks in the glomerulus, which should facilitate detected only by a single method, or genes detected by only the analysis of expression data from glomerular disease sit- two of five methods likely also reflects the high complexity uations and help in identifying disease-related pathways of the glomerular transcriptome, confirmed, for example, and mechanisms. by large-scale sequencing of glomerular cDNA libraries.21 We assume that genes contributing major functions in the glomerulus are evolutionary conserved between human and CONCISE METHODS mouse and that each approach applied to date carries the potential for identifying the most significant genes in the glomerulus in relation to the respective scopes of the stud- Transcriptome Meta-analysis ies. From this assumption follows that the results of each EST Libraries Comparison. approach are likely biologically meaningful and comple- By comparing glomerulus EST libraries with whole-kidney mentary to each other and that the pooled results, as pre- EST libraries as previously reported,21 497 mouse genes sented here, provide a fuller and more useful picture of the were identified as more than three-fold enriched in glomer- glomerular transcriptome than any of the studies alone. ulus. They were mapped to homologous human genes by Whereas emerging experimental data will undoubtedly NCBI HomoloGene assembly (http://www.ncbi.nlm.nih. modify this picture, we argue that the glomerulus-enriched gov/sites/entrez?dbϭhomologene). gene catalogue presented here is of value to current ne- phrology research. With its defined method of construc- Glomerulus-Specific cDNA Microarray Profiling (GlomChip). tion, free access, and possibilities for updating, the glomer- As described previously,17 357 mouse genes were identified as ular gene catalogue should enhance our understanding of more than two-fold upregulated in the mouse glomerulus the molecular makeup of the kidney glomerulus and find compared with rest of kidney. They were mapped to homolo- use as a source of reference information for glomerulus dis- gous human genes by NCBI HomoloGene assembly. ease research. On the basis of the current version of the glomerular gene SAGE Profiling. catalogue, we constructed GlomNet to facilitate identifica- From the SAGE profiling,23 229 tags displayed significant tion of glomerular protein networks (Figure 1A). To our higher expression level in the glomerulus than in other parts of knowledge, this is the first attempt to describe the glomer- the nephron. The threshold for statistical significance was set ulus by a systems biology approach. We predict that Glom- to P Ͻ 0.01 and seven-fold or more difference with at least

266 Journal of the American Society of Nephrology J Am Soc Nephrol 19: 260–268, 2008 www.jasn.org BASIC RESEARCH three other nephron libraries. The unambiguously annotated integrated project LYMPHANGIOGENOMICS, LSHG-CT-2004- tags were mapped to 153 human Entrez genes. 503573; and the Inga-Britt and Arne Lundberg Foundation (C.B.).

Stanford 41,859 cDNA Microarray Profiling. 22 Stringent criteria (described by Higgins et al. ) were used to DISCLOSURES produce a glomerular cluster with 196 clones whose IDs were None. searched in the SOURCE database (http://source.stan- ford.edu/cgi-bin/source/sourceSearch) and mapped to the corresponding Entrez Gene ID (Locuslink ID). A total of 162 clones that were unambiguously annotated were included in REFERENCES the analysis. They were mapped to 102 human Entrez genes. 1. Somlo S, Mundel P: Getting a foothold in nephrotic syndrome. Nat Affymetrix Expression Array Profiling. Genet 24: 333–335, 2000 2. Khoshnoodi J, Tryggvason K: Unraveling the molecular make-up of The RNA from mouse glomeruli and nonglomerular kidney the glomerular podocyte slit diaphragm. Exp Nephrol 9: 355–359, tissue at P5 stage were isolated as described previously.17 Four 2001 glomerulus RNA samples and four nonglomerular kidney tis- 3. Hudson BG, Tryggvason K, Sundaramoorthy M, Neilson EG: Alport’s sue sample were individually hybridized on eight Affymetrix syndrome, Goodpasture’s syndrome, and type IV . N Engl Mouse Genome 430 2.0 arrays. J Med 348: 2543–2556, 2003 4. Ly J, Alexander M, Quaggin SE: A podocentric view of nephrology. The array data were processed using Affy Package, and raw Curr Opin Nephrol Hypertens 13: 299–305, 2004 data were normalized using the gcrma package in the Biocon- 5. Kestila M, Lenkkeri U, Mannikko M, Lamerdin J, McCready P, Putaala ductor project (http://www.bioconductor.org). The t test was H, Ruotsalainen V, Morita T, Nissinen M, Herva R, Kashtan CE, Pel- used to evaluate differential expression between glomerulus tonen L, Holmberg C, Olsen A, Tryggvason K: Positionally cloned and nonglomerular kidney tissue sample. Multiple test correc- gene for a novel glomerular protein—nephrin—is mutated in congen- ital nephrotic syndrome. Mol Cell 1: 575–582, 1998 tion of P values was done using the false discovery rate meth- 6. Boute N, Gribouval O, Roselli S, Benessy F, Lee H, Fuchshuber A, od.34 The fold change was calculated as the average expression Dahan K, Gubler MC, Niaudet P, Antignac C: NPHS2, encoding the difference between glomeruli and nonglomerular kidney tis- glomerular protein podocin, is mutated in autosomal recessive ste- sue. The genes with more than two-fold upregulation in the roid-resistant nephrotic syndrome. Nat Genet 24: 349–354, 2000 glomeruli and corrected statistic P Ͻ 0.05 were identified as 7. Kaplan JM, Kim SH, North KN, Rennke H, Correia LA, Tong HQ, Mathis BJ, Rodriguez-Perez JC, Allen PG, Beggs AH, Pollak MR: glomerulus-enriched genes. They were mapped to homolo- Mutations in ACTN4, encoding alpha-actinin-4, cause familial focal gous human genes by NCBI HomoloGene assembly. segmental glomerulosclerosis. Nat Genet 24: 251–256, 2000 8. Chen H, Lun Y, Ovchinnikov D, Kokubo H, Oberg KC, Pepicelli CV, Gan L, Lee B, Johnson RL: Limb and kidney defects in Lmx1b mutant Construction of GlomNet mice suggest an involvement of LMX1B in human nail patella syn- The protein–protein interaction pairs were downloaded from HPRD drome. Nat Genet 19: 51–55, 1998 (release 6). The R program (http://www.r-project.org/) was used for 9. Dreyer SD, Zhou G, Baldini A, Winterpacht A, Zabel B, Cole W, Johnson RL, Lee B: Mutations in LMX1B cause abnormal skeletal the data processing. The interaction pairs formed by homophilic in- patterning and renal dysplasia in nail patella syndrome. Nat Genet 19: teraction of one protein were excluded. The interaction pairs formed 47–50, 1998 by two glomerulus-enriched gene products were selected for further 10. Klamt B, Koziell A, Poulat F, Wieacker P, Scambler P, Berta P, Gessler analysis. M: Frasier syndrome is caused by defective of WT1 ϩ The network visualization was done by using the Cytoscape pro- leading to an altered ratio of WT1 /-KTS splice isoforms. Hum Mol Genet 7: 709–714, 1998 gram.35 Cerebral plug-in was used to layout using subcellular local- 11. Barker DF, Hostikka SL, Zhou J, Chow LT, Oliphant AR, Gerken SC, 36 ization annotation. The protein cellular localization annotations Gregory MC, Skolnick MH, Atkin CL, Tryggvason K: Identification of were downloaded from HPRD. The proteins were classified to extra- mutations in the COL4A5 collagen gene in Alport syndrome. Science cellular, plasma membrane, cytoplasm, and nucleus on the basis of 248: 1224–1227, 1990 their cellular compartment annotation and positioned in the corre- 12. Mochizuki T, Lemmink HH, Mariyama M, Antignac C, Gubler MC, Pirson Y, Verellen-Dumoulin C, Chan B, Schroder CH, Smeets HJ, et sponding layers in the graph. The proteins that are not annotated to al.: Identification of mutations in the alpha 3(IV) and alpha 4(IV) colla- these four categories were allowed to place in any layer optimized by gen genes in autosomal recessive Alport syndrome. Nat Genet 8: the layout. 77–81, 1994 13. Doyonnas R, Kershaw DB, Duhme C, Merkens H, Chelliah S, Graf T, McNagny KM: Anuria, omphalocele, and perinatal lethality in mice lacking the CD34-related protein podocalyxin. J Exp Med 194: 13–27, ACKNOWLEDGMENTS 2001 14. Shih NY, Li J, Karpitskii V, Nguyen A, Dustin ML, Kanagawa O, Miner JH, Shaw AS: Congenital nephrotic syndrome in mice lacking CD2- This study was supported in part by grants from the Swedish Research associated protein. Science 286: 312–315, 1999 Council and Novo Nordisk, Strategic Research, So¨derberg, Hedlund 15. Donoviel DB, Freed DD, Vogel H, Potter DG, Hawkins E, Barrish JP, and Wallenberg foundations (C.B. and K.T.); EU 6th frame work Mathur BN, Turner CA, Geske R, Montgomery CA, Starbuck M, Brandt

J Am Soc Nephrol 19: 260–268, 2008 Systems Biology of the Glomerulus 267 BASIC RESEARCH www.jasn.org

M, Gupta A, Ramirez-Solis R, Zambrowicz BP, Powell DR: on . Mol Cell Proteomics 4: 1920–1932, 2005 and perinatal lethality in mice lacking NEPH1, a novel protein with 25. Gandhi TK, Zhong J, Mathivanan S, Karthick L, Chandrika KN, Mohan to NEPHRIN. Mol Cell Biol 21: 4829–4836, 2001 SS, Sharma S, Pinkert S, Nagaraju S, Periaswamy B, Mishra G, Nanda- 16. Ciani L, Patel A, Allen ND, ffrench-Constant C: Mice lacking the giant kumar K, Shen B, Deshpande N, Nayak R, Sarker M, Boeke JD, protocadherin mFAT1 exhibit renal slit junction abnormalities and a Parmigiani G, Schultz J, Bader JS, Pandey A: Analysis of the human partially penetrant cyclopia and anophthalmia phenotype. Mol Cell protein interactome and comparison with yeast, worm and fly inter- Biol 23: 3575–3582, 2003 action datasets. Nat Genet 38: 285–293, 2006 17. Takemoto M, He L, Norlin J, Patrakka J, Xiao Z, Petrova T, Bondjers C, 26. Huber TB, Kottgen M, Schilling B, Walz G, Benzing T: Interaction with Asp J, Wallgard E, Sun Y, Samuelsson T, Mostad P, Lundin S, Miura N, podocin facilitates nephrin signaling. J Biol Chem 276: 41543–41546, Sado Y, Alitalo K, Quaggin SE, Tryggvason K, Betsholtz C: Large-scale 2001 identification of genes implicated in kidney glomerulus development 27. Verma R, Wharram B, Kovari I, Kunkel R, Nihalani D, Wary KK, Wiggins and function. EMBO J 25: 1160–1174, 2006 RC, Killen P, Holzman LB: Fyn binds to and phosphorylates the kidney 18. Cui S, Schwartz L, Quaggin SE: Pod1 is required in stromal cells for slit diaphragm component Nephrin. J Biol Chem 278: 20716–20723, glomerulogenesis. Dev Dyn 226: 512–522, 2003 2003 19. Wharram BL, Goyal M, Gillespie PJ, Wiggins JE, Kershaw DB, Holzman 28. Leveen P, Pekny M, Gebre-Medhin S, Swolin B, Larsson E, Betsholtz C: LB, Dysko RC, Saunders TL, Samuelson LC, Wiggins RC: Altered Mice deficient for PDGF B show renal, cardiovascular, and hemato- podocyte structure in GLEPP1 (Ptpro)-deficient mice associated with logical abnormalities. Genes Dev 8: 1875–1887, 1994 hypertension and low glomerular filtration rate. J Clin Invest 106: 29. Soriano P: Abnormal kidney development and hematological disor- 1281–1290, 2000 ders in PDGF beta-receptor mutant mice. Genes Dev 8: 1888–1896, 20. Mundel P, Heid HW, Mundel TM, Kruger M, Reiser J, Kriz W: Synap- 1994 topodin: An -associated protein in telencephalic dendrites and 30. Eremina V, Quaggin SE: The role of VEGF-A in glomerular develop- renal podocytes. J Cell Biol 139: 193–204, 1997 ment and function. Curr Opin Nephrol Hypertens 13: 9–15, 2004 21. He L, Sun Y, Patrakka J, Mostad P, Norlin J, Xiao Z, Andrae J, 31. Baelde HJ, Eikmans M, Doran PP, Lappin DW, de Heer E, Bruijn JA: Tryggvason K, Samuelsson T, Betsholtz C, Takemoto M: Glomerulus- Gene expression profiling in glomeruli from human kidneys with dia- specific mRNA transcripts and proteins identified through kidney ex- betic nephropathy. Am J Kidney Dis 43: 636–650, 2004 pressed sequence tag database analysis. Kidney Int 71: 889–900, 32. Schwarz K, Simons M, Reiser J, Saleem MA, Faul C, Kriz W, Shaw AS, 2007 Holzman LB, Mundel P: Podocin, a raft-associated component of the 22. Higgins JP, Wang L, Kambham N, Montgomery K, Mason V, Vo- glomerular slit diaphragm, interacts with CD2AP and nephrin. J Clin gelmann SU, Lemley KV, Brown PO, Brooks JD, van de Rijn M: Gene Invest 108: 1621–1629, 2001 expression in the normal adult human kidney assessed by comple- 33. Liu G, Kaw B, Kurfis J, Rahmanuddin S, Kanwar YS, Chugh SS: Neph1 mentary DNA microarray. Mol Biol Cell 15: 649–656, 2004 and nephrin interaction in the slit diaphragm is an important determi- 23. Chabardes-Garonne D, Mejean A, Aude JC, Cheval L, Di Stefano A, nant of glomerular permeability. J Clin Invest 112: 209–221, 2003 Gaillard MC, Imbert-Teboul M, Wittner M, Balian C, Anthouard V, 34. Benjamini Y, Hochberg Y: Controlling the false discovery rate: A Robert C, Segurens B, Wincker P, Weissenbach J, Doucet A, Elalouf practical and powerful approach to multiple testing. J R Stat Soc Ser JM: A panoramic view of gene expression in the human kidney. Proc B 57: 289–300, 1995 Natl Acad Sci U S A 100: 13710–13715, 2003 35. Shannon P, Markiel A, Ozier O, Baliga NS, Wang JT, Ramage D, Amin 24. Uhlen M, Bjorling E, Agaton C, Szigyarto CA, Amini B, Andersen E, N, Schwikowski B, Ideker T: Cytoscape: A software environment for Andersson AC, Angelidou P, Asplund A, Asplund C, Berglund L, integrated models of biomolecular interaction networks. Genome Res Bergstrom K, Brumer H, Cerjan D, Ekstrom M, Elobeid A, Eriksson C, 13: 2498–2504, 2003 Fagerberg L, Falk R, Fall J, Forsberg M, Bjorklund MG, Gumbel K, 36. Barsky A, Gardy JL, Hancock RE, Munzner T: Cerebral: A Cytoscape Halimi A, Hallin I, Hamsten C, Hansson M, Hedhammar M, Hercules G, plugin for layout of and interaction with biological networks using Kampf C, Larsson K, Lindskog M, Lodewyckx W, Lund J, Lundeberg J, subcellular localization annotation. Bioinformatics 23: 1040–1042, Magnusson K, Malm E, Nilsson P, Odling J, Oksvold P, Olsson I, Oster 2007 E, Ottosson J, Paavilainen L, Persson A, Rimini R, Rockberg J, Runeson M, Sivertsson A, Skollermo A, Steen J, Stenvall M, Sterky F, Stromberg S, Sundberg M, Tegel H, Tourle S, Wahlund E, Walden A, Wan J, Wernerus H, Westberg J, Wester K, Wrethagen U, Xu LL, Hober S, Supplemental information for this article is available online at http://www. Ponten F: A human protein atlas for normal and tissues based jasn.org/.

268 Journal of the American Society of Nephrology J Am Soc Nephrol 19: 260–268, 2008 Supplement Table S3

Entrez Gene ID Symbol Gene name Up-regulated fold 1 3123 HLA-DRB1 major histocompatibility complex, class II, DR beta 1 4.46 2 81544 GDPD5 glycerophosphodiester phosphodiesterase domain containing 5 4.37 3 5797 PTPRM protein tyrosine phosphatase, receptor type, M 3.25 4 9647 PPM1F 1F (PP2C domain containing) 2.83 5 4855 NOTCH4 Notch homolog 4 (Drosophila) 2.73 6 7123 CLEC3B C-type lectin domain family 3, member B 2.60 7 1393 CRHBP corticotropin releasing hormone binding protein 2.52 8 5138 PDE2A phosphodiesterase 2A, cGMP-stimulated 2.47 9 51763 SKIP and kidney enriched inositol phosphatase 2.46 10 1396 CRIP1 cysteine-rich protein 1 (intestinal) 2.45 11 7010 TEK TEK tyrosine , endothelial (venous malformations, multip 2.38 12 947 CD34 CD34 molecule 2.37 13 10266 RAMP2 receptor (-coupled) activity modifying protein 2 2.36 14 2009 EML1 echinoderm associated protein like 1 2.25 15 4134 MAP4 microtubule-associated protein 4 2.24 16 5787 PTPRB protein tyrosine phosphatase, receptor type, B 2.20 17 7075 TIE1 with immunoglobulin-like and EGF-like domains 2.16 18 221395 GPR116 G protein-coupled receptor 116 2.16 19 94 ACVRL1 activin A receptor type II-like 1 2.14 20 2022 ENG (Osler-Rendu-Weber syndrome 1) 2.13 21 8613 PPAP2B phosphatidic acid phosphatase type 2B 2.09 22 10327 AKR1A1 aldo-keto reductase family 1, member A1 (aldehyde reductase) 2.02 23 3397 ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix p 2.02 24 3384 ICAM2 intercellular adhesion molecule 2 2.02 25 3488 IGFBP5 -like binding protein 5 2.01 Supplement Table S4

Entrez Gene ID Symbol Gene name Down-regulated fold 1 53405 CLIC5 chloride intracellular channel 5 20.15 2 79625 C4orf31 4 open reading frame 31 19.26 3 650 BMP2 morphogenetic protein 2 18.27 4 23109 DDN dendrin 17.68 5 259217 HSPA12A heat shock 70kDa protein 12A 17.54 6 51196 PLCE1 , epsilon 1 15.57 7 5800 PTPRO protein tyrosine phosphatase, receptor type, O 14.68 8 5730 PTGDS prostaglandin D2 synthase 21kDa () 14.33 9 4311 MME membrane metallo- (neutral endopeptidase, enkep 14.01 10 2028 ENPEP glutamyl (aminopeptidase A) 13.54 11 199 AIF1 allograft inflammatory factor 1 12.50 12 1286 COL4A4 collagen, type IV, alpha 4 11.21 13 23213 SULF1 sulfatase 1 10.48 14 22925 PLA2R1 phospholipase A2 receptor 1, 180kDa 10.40 15 5058 PAK1 /Cdc42/Rac1-activated kinase 1 (STE20 homolog, yeast) 9.14 16 55752 SEPT11 septin 11 8.94 17 6943 TCF21 21 8.45 18 9863 MAGI2 membrane associated guanylate kinase, WW and PDZ domain c 8.22 19 7139 TNNT2 T type 2 (cardiac) 8.19 20 2152 F3 coagulation factor III (thromboplastin, ) 7.83 21 5734 PTGER4 prostaglandin E receptor 4 (subtype EP4) 7.64 22 7422 VEGFA vascular endothelial growth factor A 7.52 23 10402 ST3GAL6 ST3 beta-galactoside alpha-2,3-sialyltransferase 6 7.19 24 7301 TYRO3 TYRO3 protein tyrosine kinase 6.98 25 2149 F2R coagulation factor II (thrombin) receptor 6.93 26 347 APOD apolipoprotein D 6.69 27 1490 CTGF connective tissue growth factor 6.58 28 23022 PALLD palladin, cytoskeletal associated protein 6.51 29 4189 DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9 6.49 30 7490 WT1 Wilms tumor 1 6.42 31 7739 ZNF185 protein 185 (LIM domain) 6.39 32 51232 CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 6.23 33 1545 CYP1B1 , family 1, subfamily B, polypeptide 1 6.14 34 10602 CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3 6.08 35 9636 ISG15 ISG15 -like modifier 6.01 36 221981 THSD7A , type I, domain containing 7A 6.00 37 4868 NPHS1 nephrosis 1, congenital, Finnish type (nephrin) 5.94 38 1285 COL4A3 collagen, type IV, alpha 3 (Goodpasture antigen) 5.85 39 2195 FAT FAT tumor suppressor homolog 1 (Drosophila) 5.82 40 9806 SPOCK2 sparc/, cwcv and kazal-like domains proteoglycan (te 5.76 41 9037 SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1 5.48 42 3485 IGFBP2 insulin-like growth factor binding protein 2, 36kDa 5.36 43 5654 HTRA1 HtrA serine peptidase 1 5.30 44 3621 ING1 inhibitor of growth family, member 1 5.29 45 1028 CDKN1C -dependent kinase inhibitor 1C (p57, Kip2) 4.94 46 7049 TGFBR3 transforming growth factor, beta receptor III 4.81 47 4023 LPL lipoprotein lipase 4.77 48 10391 CORO2B coronin, actin binding protein, 2B 4.66 49 715 C1R complement component 1, r subcomponent 4.63 50 2697 GJA1 protein, alpha 1, 43kDa 4.47 51 716 C1S complement component 1, s subcomponent 4.36 52 25999 CLIP3 CAP-GLY domain containing linker protein 3 4.08 53 23114 NFASC neurofascin homolog (chicken) 4.05 54 23380 SRGAP2 SLIT-ROBO Rho GTPase 3.92 55 1605 DAG1 1 (-associated glycoprotein 1) 3.92 56 5653 KLK6 kallikrein-related peptidase 6 3.91 57 8556 CDC14A CDC14 cell division cycle 14 homolog A (S. cerevisiae) 3.91 58 10398 MYL9 , chain 9, regulatory 3.85 59 961 CD47 CD47 molecule 3.73 60 56941 C3orf37 open reading frame 37 3.72 61 9435 CHST2 carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2 3.71 62 3693 ITGB5 , beta 5 3.68 63 7357 UGCG UDP-glucose ceramide glucosyltransferase 3.68 64 5352 PLOD2 procollagen-, 2-oxoglutarate 5-dioxygenase 2 3.64 65 1604 CD55 CD55 molecule, decay accelerating factor for complement (Crom 3.58 66 4638 MYLK myosin, light chain kinase 3.57 67 10217 CTDSPL CTD (carboxy-terminal domain, RNA polymerase II, polypeptide 3.54 68 868 CBLB Cas-Br-M (murine) ecotropic retroviral transforming sequence b 3.53 69 9748 SLK STE20-like kinase (yeast) 3.51 70 10521 DDX17 DEAD (Asp-Glu-Ala-Asp) box polypeptide 17 3.40 71 805 CALM2 2 (phosphorylase kinase, delta) 3.37 72 2920 CXCL2 chemokine (C-X-C motif) 2 3.29 73 4170 MCL1 myeloid cell leukemia sequence 1 (BCL2-related) 3.17 74 29970 SCHIP1 schwannomin interacting protein 1 3.16 75 3675 ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 recep 3.01 76 1843 DUSP1 dual specificity phosphatase 1 2.89 77 4204 MECP2 methyl CpG binding protein 2 () 2.83 78 5420 PODXL podocalyxin-like 2.81 79 133 ADM 2.79 80 2869 GRK5 G protein-coupled receptor kinase 5 2.79 81 10140 TOB1 transducer of ERBB2, 1 2.78 82 5054 SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator 2.76 83 8519 IFITM1 interferon induced transmembrane protein 1 (9-27) 2.71 84 8412 BCAR3 breast cancer anti-estrogen resistance 3 2.68 85 120 ADD3 adducin 3 (gamma) 2.65 86 23370 ARHGEF18 rho/ guanine exchange factor (GEF) 18 2.64 87 9788 MTSS1 metastasis suppressor 1 2.61 88 301 ANXA1 A1 2.60 89 7091 TLE4 -like of split 4 (E(sp1) homolog, Drosophila) 2.56 90 26471 NUPR1 nuclear protein 1 2.54 91 54587 MXRA8 matrix-remodelling associated 8 2.54 92 1647 GADD45A growth arrest and DNA-damage-inducible, alpha 2.52 93 7453 WARS tryptophanyl-tRNA synthetase 2.52 94 558 AXL AXL receptor .51 95 7073 TIAL1 TIA1 cytotoxic granule-associated RNA binding protein-like 1 2.51 96 11346 SYNPO synaptopodin 2.48 97 1595 CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1 2.48 98 2534 FYN FYN oncogene related to SRC, FGR, YES 2.47 99 3320 HSP90AA1 90kDa alpha (cytosolic), class A member 1 2.46 100 2316 FLNA A, alpha (actin binding protein 280) 2.45 101 7431 VIM 2.45 102 10370 CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-te 2.42 103 10631 POSTN periostin, osteoblast specific factor 2.41 104 56288 PARD3 par-3 partitioning defective 3 homolog (C. elegans) 2.40 105 9846 GAB2 GRB2-associated binding protein 2 2.39 106 23741 EID1 EP300 interacting inhibitor of differentiation 1 2.37 107 330 BIRC3 baculoviral IAP repeat-containing 3 2.36 108 4643 MYO1E myosin IE 2.33 109 1859 DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 2.32 110 6595 SMARCA2 SWI/SNF related, matrix associated, actin dependent regulator o 2.32 111 84159 ARID5B AT rich interactive domain 5B (MRF1-like) 2.30 112 5516 PPP2CB (formerly 2A), catalytic subunit, beta isofo 2.28 113 3301 DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 2.27 114 9180 OSMR receptor 2.23 115 7290 HIRA HIR histone regulation defective homolog A (S. cerevis 2.23 116 10096 ACTR3 ARP3 actin-related protein 3 homolog (yeast) 2.21 117 10627 MRCL3 myosin regulatory light chain MRCL3 2.21 118 10133 OPTN optineurin 2.20 119 5928 RBBP4 retinoblastoma binding protein 4 2.18 120 4059 BCAM basal molecule (Lutheran blood group) 2.15 121 28951 TRIB2 tribbles homolog 2 (Drosophila) 2.15 122 4664 NAB1 NGFI-A binding protein 1 (EGR1 binding protein 1) 2.14 123 3490 IGFBP7 insulin-like growth factor binding protein 7 2.08 124 71 ACTG1 actin, gamma 1 2.07 125 9231 DLG5 discs, large homolog 5 (Drosophila) 2.06 126 23048 FNBP1 formin binding protein 1 2.04 127 7534 YWHAZ tyrosine 3-/tryptophan 5-monooxygenase activat 2.03 128 9778 KIAA0232 KIAA0232 gene product 1.80 129 7322 UBE2D2 ubiquitin-conjugating E2D 2 (UBC4/5 homolog, yeast) 1.78

Entrez Gene Symbol Gene Name Affymetrix EST Glomchip SAGE Stanford Literature HPA confirmed Gene ID Profiling profiling Profiling Profiling array profiling confirmed

1 2 A2M alpha-2-macroglobulin 0 0 0 1 0 2 10347 ABCA7 ATP-binding cassette, sub-family A (ABC1), member 7 1 0 0 0 0 3 10350 ABCA9 ATP-binding cassette, sub-family A (ABC1), member 9 1 0 0 0 0 4 10057 ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 1 0 0 0 0 5 10060 ABCC9 ATP-binding cassette, sub-family C (CFTR/MRP), member 9 1 0 0 0 0 6 79575 ABHD8 abhydrolase domain containing 8 1 0 0 0 0 7 51225 ABI3 ABI gene family, member 3 1 0 1 0 0 8 29 ABR active BCR-related gene 1 0 0 0 0 9 25841 ABTB2 repeat and BTB (POZ) domain containing 2 1 0 1 0 0 10 30 ACAA1 acetyl-Coenzyme A 1 (peroxisomal 3-oxoacyl-Coenzyme A thiol 0 1 0 0 0 11 43 ACHE acetylcholinesterase (Yt blood group) 1 0 0 0 0 12 58 ACTA1 actin, alpha 1, skeletal muscle 0 1 0 0 0 13 60 ACTB actin, beta 01000 1 14 71 ACTG1 actin, gamma 1 0 1 0 0 0 15 81 ACTN4 actinin, alpha 4 0 0 1 1 1 10700177 16 10096 ACTR3 ARP3 actin-related protein 3 homolog (yeast) 0 1 0 0 0 17 94 ACVRL1 activin A receptor type II-like 1 1 0 1 0 0 18 8038 ADAM12 ADAM metallopeptidase domain 12 (meltrin alpha) 1 0 0 0 0 19 8751 ADAM15 ADAM metallopeptidase domain 15 (metargidin) 1 0 0 0 0 20 8728 ADAM19 ADAM metallopeptidase domain 19 (meltrin beta) 1 0 0 0 0 21 81792 ADAMTS12 ADAM metallopeptidase with thrombospondin type 1 motif, 12 1 0 0 0 0 22 9507 ADAMTS4 ADAM metallopeptidase with thrombospondin type 1 motif, 4 0 0 1 0 0 23 11096 ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5 (aggrecanase-2) 1 0 1 0 0 24 56999 ADAMTS9 ADAM metallopeptidase with thrombospondin type 1 motif, 9 0 0 0 0 1 25 107 ADCY1 adenylate 1 (brain) 1 0 1 0 0 26 196883 ADCY4 adenylate cyclase 4 1 0 1 0 0 27 120 ADD3 adducin 3 (gamma) 0 0 0 1 0 28 133 ADM adrenomedullin 1 0 0 0 0 9564831 29 165 AEBP1 AE binding protein 1 1 0 0 0 0 30 166 AES amino-terminal enhancer of split 0 0 0 1 0 31 84632 AFAP1L2 actin filament associated protein 1-like 2 1 0 0 0 0 32 177 AGER advanced glycosylation end product-specific receptor 1 0 1 0 0 12651605 33 56895 AGPAT4 1-acylglycerol-3-phosphate O-acyltransferase 4 ( acyltrans 10100 34 187 AGTRL1 II receptor-like 1 0 0 0 1 1 35 79026 AHNAK AHNAK (desmoyokin) 0 1 0 1 0 36 199 AIF1 allograft inflammatory factor 1 0 0 0 1 1 37 203 AK1 adenylate kinase 1 1 0 1 0 0 38 9590 AKAP12 A kinase (PRKA) anchor protein (gravin) 12 1 0 0 0 0 39 10142 AKAP9 A kinase (PRKA) anchor protein (yotiao) 9 0 0 1 0 0 40 10327 AKR1A1 aldo-keto reductase family 1, member A1 (aldehyde reductase) 0 1 0 0 0 41 208 AKT2 v-akt murine thymoma viral oncogene homolog 2 1 0 0 0 0 42 10000 AKT3 v-akt murine thymoma viral oncogene homolog 3 ( B, gamma) 1 0 0 0 0 43 239 ALOX12 arachidonate 12-lipoxygenase 1 0 0 0 0 44 259173 ALS2CL ALS2 C-terminal like 0 0 0 0 1 45 154810 AMOTL1 angiomotin like 1 1 0 0 0 0 46 64682 ANAPC1 anaphase promoting complex subunit 1 0 1 0 0 0 47 23452 ANGPTL2 -like 2 1 1 1 0 0 48 29123 ANKRD11 ankyrin repeat domain 11 1 0 0 0 0 49 163782 ANKRD38 ankyrin repeat domain 38 1 1 0 0 0 50 91526 ANKRD44 ankyrin repeat domain 44 1 0 0 0 0 51 256949 ANKRD47 ankyrin repeat domain 47 1 0 0 0 0 52 57182 ANKRD50 ankyrin repeat domain 50 1 0 0 0 0 53 22881 ANKRD6 ankyrin repeat domain 6 1 0 0 0 0 54 301 ANXA1 10010 55 302 ANXA2 1 1 1 1 0 16249193 56 306 ANXA3 annexin A3 10100 57 308 ANXA5 0 1 0 0 0 11271515 58 8905 AP1S2 adaptor-related protein complex 1, sigma 2 subunit 0 0 0 0 1 59 323 APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 (Fe65-like) 1 0 0 0 0 60 333 APLP1 amyloid beta (A4) precursor-like protein 1 1 0 0 0 1 61 347 APOD apolipoprotein D 0 0 0 1 0 62 81575 APOLD1 apolipoprotein L domain containing 1 0 0 1 0 0 63 375 ARF1 ADP-ribosylation factor 1 0 1 0 0 0 14684384 64 79822 ARHGAP28 Rho GTPase activating protein 28 1 0 0 0 1 65 55160 ARHGEF10L Rho guanine nucleotide exchange factor (GEF) 10-like 0 1 0 0 0 66 23365 ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 1 0 0 0 0 67 9828 ARHGEF17 Rho guanine nucleotide exchange factor (GEF) 17 1 0 0 0 0 68 23370 ARHGEF18 rho/rac guanine nucleotide exchange factor (GEF) 18 1 0 0 0 0 69 50650 ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3 1 0 0 0 0 70 9459 ARHGEF6 Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6 1 0 0 0 0 1 71 10865 ARID5A AT rich interactive domain 5A (MRF1-like) 1 0 0 0 0 72 84159 ARID5B AT rich interactive domain 5B (MRF1-like) 0 0 1 0 0 73 200894 ARL13B ADP-ribosylation factor-like 13B 0 1 0 0 0 74 23204 ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0 1 0 0 0 75 10550 ARL6IP5 ADP-ribosylation-like factor 6 interacting protein 5 0 0 1 0 0 76 219681 ARMC3 armadillo repeat containing 3 1 0 0 0 0 77 51309 ARMCX1 armadillo repeat containing, X-linked 1 1 0 0 0 0 78 158947 ARMCX4 armadillo repeat containing, X-linked 4 1 0 0 0 0 79 10095 ARPC1B actin related protein 2/3 complex, subunit 1B, 41kDa 1 0 0 0 0 80 10109 ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa 0 1 1 0 0 81 10093 ARPC4 actin related protein 2/3 complex, subunit 4, 20kDa 0 1 0 0 0 82 408 ARRB1 , beta 1 1 0 0 0 0 1 83 419 ART3 ADP-ribosyltransferase 3 1 0 1 0 0 84 421 ARVCF armadillo repeat gene deletes in velocardiofacial syndrome 1 0 1 0 0 85 340485 ASAH3L N-acylsphingosine amidohydrolase 3-like 1 0 0 0 0 86 23020 ASCC3L1 activating signal cointegrator 1 complex subunit 3-like 1 0 1 0 0 0 87 25842 ASF1A ASF1 anti-silencing function 1 homolog A (S. cerevisiae) 0 0 1 0 0 88 460 ASTN1 astrotactin 1 10000 89 468 ATF4 activating transcription factor 4 (tax-responsive enhancer element B67) 0 1 0 0 0 90 57194 ATP10A ATPase, Class V, type 10A 0 0 0 0 1 91 57205 ATP10D ATPase, Class V, type 10D 1 0 0 0 0 92 482 ATP1B2 ATPase, Na+/K+ transporting, beta 2 polypeptide 1 0 0 0 0 93 489 ATP2A3 ATPase, Ca++ transporting, ubiquitous 1 0 0 0 0 94 8992 ATP6V0E1 ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1 0 1 0 0 0 95 9550 ATP6V1G1 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G1 0 1 0 1 0 96 10396 ATP8A1 ATPase, aminophospholipid transporter (APLT), Class I, type 8A, member 1 1 1 0 0 1 97 8455 ATRN attractin 00100 98 26033 ATRNL1 attractin-like 1 01000 99 6311 ATXN2 ataxin 2 00010 100 558 AXL AXL 1 0 0 0 0 101 79888 AYTL2 acyltransferase like 2 1 0 0 0 0 102 567 B2M beta-2-microglobulin 0 1 0 1 0 103 145173 B3GALTL beta 1,3-galactosyltransferase-like 0 1 0 0 0 104 60468 BACH2 BTB and CNC homology 1, basic transcription factor 2 0 0 0 1 0 105 4059 BCAM basal cell adhesion molecule (Lutheran blood group) 0 1 0 1 0 11507772 106 8412 BCAR3 breast cancer anti-estrogen resistance 3 1 0 0 1 0 107 255877 BCL6B B-cell CLL/ 6, member B (zinc finger protein) 1 0 0 0 0 108 633 BGN biglycan 00010 1 109 23299 BICD2 bicaudal D homolog 2 (Drosophila) 1 0 1 0 0 110 330 BIRC3 baculoviral IAP repeat-containing 3 1 0 0 0 0 111 54739 BIRC4BP XIAP associated factor-1 1 0 0 0 0 112 645 BLVRB biliverdin reductase B (flavin reductase (NADPH)) 0 1 0 0 0 113 650 BMP2 bone morphogenetic protein 2 1 0 0 0 0 114 168667 BMPER BMP binding endothelial regulator 1 0 0 0 0 115 663 BNIP2 BCL2/adenovirus E1B 19kDa interacting protein 2 1 0 0 0 0 116 665 BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0 0 0 1 0 117 91653 BOC Boc homolog (mouse) 1 0 0 0 0 118 2186 BPTF bromodomain PHD finger transcription factor 0 1 0 0 0 119 23476 BRD4 bromodomain containing 4 0 1 0 0 0 120 26228 BRDG1 BCR downstream signaling 1 0 0 0 1 0 121 25874 BRP44 brain protein 44 0 1 0 0 0 122 682 BSG (Ok blood group) 0 1 0 0 0 123 9044 BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa (Mo 10000 124 689 BTF3 basic transcription factor 3 0 1 0 0 0 125 11067 C10orf10 open reading frame 10 1 0 0 0 0 126 64115 C10orf54 chromosome 10 open reading frame 54 1 0 0 0 0 127 747 C11orf11 open reading frame 11 1 1 0 0 0 128 54949 C11orf79 chromosome 11 open reading frame 79 0 1 0 0 0 129 55196 C12orf35 open reading frame 35 0 0 0 0 1 130 57213 C13orf1 open reading frame 1 0 1 0 0 0 131 283489 C13orf8 chromosome 13 open reading frame 8 0 0 1 0 0 132 55017 C14orf119 open reading frame 119 0 1 0 0 0 133 171546 C14orf147 chromosome 14 open reading frame 147 0 1 0 0 0 134 64423 C14orf173 chromosome 14 open reading frame 173 1 0 1 0 0 135 91828 C14orf73 chromosome 14 open reading frame 73 1 0 0 0 0 136 56851 C15orf24 open reading frame 24 1 0 0 0 0 137 80262 C16orf70 open reading frame 70 1 0 0 0 0 138 146850 C17orf38 open reading frame 38 1 0 0 0 0 139 91304 C19orf6 open reading frame 6 0 1 0 0 0 140 348487 C1orf117 open reading frame 117 0 0 0 0 1 141 79594 C1orf166 chromosome 1 open reading frame 166 0 1 0 0 0 142 84886 C1orf198 chromosome 1 open reading frame 198 1 0 0 0 0 143 81563 chromosome 1 open reading frame 21 1 0 1 0 0 144 79630 C1orf54 chromosome 1 open reading frame 54 1 0 0 0 0 145 57035 C1orf63 chromosome 1 open reading frame 63 0 0 1 0 0 146 26097 C1orf77 chromosome 1 open reading frame 77 0 1 0 0 0 147 55194 C1orf78 chromosome 1 open reading frame 78 0 0 1 0 0 148 84734 C1orf90 chromosome 1 open reading frame 90 0 0 1 0 0 149 56063 C1orf91 chromosome 1 open reading frame 91 0 1 0 0 0 150 114897 C1QTNF1 C1q and tumor necrosis factor related protein 1 1 0 1 0 0 151 114905 C1QTNF7 C1q and tumor necrosis factor related protein 7 1 0 0 0 0 152 715 C1R complement component 1, r subcomponent 0 0 0 1 0 9226227 153 716 C1S complement component 1, s subcomponent 0 0 0 1 0 9226227 154 140710 C20orf117 open reading frame 117 1 0 0 0 0 155 83541 C20orf55 chromosome 20 open reading frame 55 1 0 0 0 0 156 25966 C21orf25 chromosome 21 open reading frame 25 1 0 0 0 0 157 54149 C21orf91 chromosome 21 open reading frame 91 1 0 0 0 0 158 25829 C22orf5 open reading frame 5 1 0 0 0 0 159 192137 C2orf12 open reading frame 12 0 0 0 1 0 160 25927 C2orf32 chromosome 2 open reading frame 32 1 0 0 0 0 161 56941 C3orf37 chromosome 3 open reading frame 37 0 0 0 1 0 162 389119 C3orf54 chromosome 3 open reading frame 54 1 0 0 0 0 163 205428 C3orf58 chromosome 3 open reading frame 58 1 0 0 0 0 164 55435 C4orf16 open reading frame 16 0 1 0 0 0 165 51313 C4orf18 chromosome 4 open reading frame 18 0 0 0 0 1 166 79625 C4orf31 chromosome 4 open reading frame 31 0 0 0 1 1 167 9315 C5orf13 open reading frame 13 0 1 0 0 0 168 134359 C5orf37 chromosome 5 open reading frame 37 1 0 0 0 0 169 51306 C5orf5 chromosome 5 open reading frame 5 0 0 1 0 0 170 9750 C6orf32 open reading frame 32 1 0 0 0 0 171 79632 C6orf60 chromosome 6 open reading frame 60 1 0 0 0 0 172 56892 C8orf4 open reading frame 4 1 0 0 0 0 173 89958 C9orf140 open reading frame 140 1 0 0 0 0 174 286257 C9orf142 chromosome 9 open reading frame 142 1 0 0 0 0 175 375704 C9orf165 chromosome 9 open reading frame 165 1 0 0 0 0 176 54863 C9orf167 chromosome 9 open reading frame 167 1 0 0 0 0 177 195827 C9orf21 chromosome 9 open reading frame 21 0 1 0 0 0 178 84909 chromosome 9 open reading frame 3 1 0 1 0 0 179 158219 C9orf52 chromosome 9 open reading frame 52 1 0 0 0 0 180 54942 C9orf6 chromosome 9 open reading frame 6 0 0 1 0 0 181 91768 CABLES1 Cdk5 and Abl enzyme substrate 1 1 0 0 0 0 182 8913 CACNA1G channel, voltage-dependent, alpha 1G subunit 1 0 0 0 0 183 9254 CACNA2D2 , voltage-dependent, alpha 2/delta subunit 2 1 0 0 0 0 184 796 CALCA calcitonin/calcitonin-related polypeptide, alpha 1 0 0 0 0 185 10203 CALCRL -like 1 1 1 0 0 12242482 186 801 CALM1 calmodulin 1 (phosphorylase kinase, delta) 0 1 0 0 0 187 805 CALM2 calmodulin 2 (phosphorylase kinase, delta) 0 1 0 0 0 188 808 CALM3 calmodulin 3 (phosphorylase kinase, delta) 0 1 0 0 0 189 124583 CANT1 calcium activated nucleotidase 1 0 0 0 0 1 190 10486 CAP2 CAP, adenylate cyclase-associated protein, 2 (yeast) 1 0 0 0 0 191 29775 CARD10 caspase recruitment domain family, member 10 1 0 1 0 0 192 23589 CARHSP1 calcium regulated heat stable protein 1, 24kDa 1 0 0 0 0 193 863 CBFA2T3 core-binding factor, runt domain, alpha subunit 2; translocated to, 3 1 0 1 0 0 194 868 CBLB Cas-Br-M (murine) ecotropic retroviral transforming sequence b 1 0 0 0 0 195 11335 CBX3 chromobox homolog 3 (HP1 gamma homolog, Drosophila) 0 1 0 0 0 196 83643 CCDC3 coiled-coil domain containing 3 1 0 0 0 0 197 201134 CCDC46 coiled-coil domain containing 46 1 0 0 0 0 198 79780 CCDC82 coiled-coil domain containing 82 1 0 0 0 0 199 11007 CCDC85B coiled-coil domain containing 85B 1 0 0 0 0 200 23582 CCNDBP1 cyclin D-type binding-protein 1 0 1 0 0 0 201 22948 CCT5 containing TCP1, subunit 5 (epsilon) 0 1 0 0 0 202 10574 CCT7 chaperonin containing TCP1, subunit 7 (eta) 0 1 0 0 0 203 135228 CD109 CD109 molecule 1 1 1 0 0 204 977 CD151 CD151 molecule (Raph blood group) 1 0 0 0 0 1 205 912 CD1D CD1d molecule 1 0 0 0 0 206 4345 CD200 CD200 molecule 1 0 1 0 0 207 57124 CD248 CD248 molecule, endosialin 1 0 0 0 0 208 146894 CD300LG CD300 molecule-like family member g 1 0 1 0 0 209 947 CD34 CD34 molecule 1 1 1 0 0 12000719 1 210 952 CD38 CD38 molecule 1 0 0 0 0 211 958 CD40 CD40 molecule, TNF receptor superfamily member 5 1 0 0 0 0 212 961 CD47 CD47 molecule 1 0 0 0 0 213 1604 CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 1 0 0 0 0 12427125 214 975 CD81 CD81 molecule 0 1 0 0 0 215 22918 CD93 CD93 molecule 1 0 0 0 0 216 976 CD97 CD97 molecule 1 1 1 0 0 217 8556 CDC14A CDC14 cell division cycle 14 homolog A (S. cerevisiae) 0 0 1 0 1 218 994 CDC25B cell division cycle 25 homolog B (S. pombe) 0 0 1 0 0 219 11135 CDC42EP1 CDC42 effector protein (Rho GTPase binding) 1 1 0 0 0 0 220 10435 CDC42EP2 CDC42 effector protein (Rho GTPase binding) 2 1 0 0 0 0 221 10602 CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3 1 0 0 1 0 222 57514 CDGAP Cdc42 GTPase-activating protein 1 0 0 0 0 223 1000 CDH2 cadherin 2, type 1, N-cadherin (neuronal) 1 0 0 0 0 224 1003 CDH5 cadherin 5, type 2, VE-cadherin (vascular ) 1 1 0 0 0 9864160 225 1021 CDK6 cyclin-dependent kinase 6 0 1 0 0 0 226 1026 CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 1 0 0 0 0 10916090 227 1028 CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2) 1 1 1 1 1 10916090 228 8760 CDS2 CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2 1 0 0 0 0 229 634 CEACAM1 -related cell adhesion molecule 1 (biliary glycoprotein) 1 0 0 0 1 1 230 90273 CEACAM21 carcinoembryonic antigen-related cell adhesion molecule 21 1 0 0 0 0 231 1051 CEBPB CCAAT/enhancer binding protein (C/EBP), beta 1 0 1 0 0 232 1052 CEBPD CCAAT/enhancer binding protein (C/EBP), delta 1 0 0 0 0 233 116984 CENTD1 centaurin, delta 1 1 0 0 0 0 234 64411 CENTD3 centaurin, delta 3 1 0 1 0 0 235 64781 CERK ceramide kinase 1 0 0 0 0 236 1072 CFL1 cofilin 1 (non-muscle) 0 1 0 0 0 237 51673 CGI-38 brain specific protein 1 0 0 0 1 238 1116 CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39) 0 0 0 1 1 239 1121 CHM ( escort protein 1) 0 1 0 0 0 240 51510 CHMP5 modifying protein 5 0 1 0 0 0 241 79643 CHMP6 chromatin modifying protein 6 0 1 0 0 0 242 1131 CHRM3 cholinergic receptor, muscarinic 3 0 0 0 0 1 243 1140 CHRNB1 cholinergic receptor, nicotinic, beta 1 (muscle) 1 0 1 0 0 244 8534 CHST1 carbohydrate (keratan sulfate Gal-6) sulfotransferase 1 1 0 1 0 0 245 9435 CHST2 carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2 1 0 0 0 0 246 10370 CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 0 0 1 0 0 16498405 247 23122 CLASP2 cytoplasmic linker associated protein 2 0 0 1 0 0 248 24146 CLDN15 claudin 15 10000 249 7122 CLDN5 claudin 5 (transmembrane protein deleted in velocardiofacial syndrome) 1 1 1 0 0 12110008 1 250 161198 CLEC14A C-type lectin domain family 14, member A 1 1 0 0 1 251 51267 CLEC1A C-type lectin domain family 1, member A 1 0 0 0 0 252 51266 CLEC1B C-type lectin domain family 1, member B 1 0 0 0 0 253 7123 CLEC3B C-type lectin domain family 3, member B 0 0 0 1 0 254 9022 CLIC3 chloride intracellular channel 3 1 0 1 0 0 255 53405 CLIC5 chloride intracellular channel 5 1 1 1 0 1 17332733 256 6249 CLIP1 CAP-GLY domain containing linker protein 1 0 1 0 0 0 257 7461 CLIP2 CAP-GLY domain containing linker protein 2 1 0 0 0 0 258 25999 CLIP3 CAP-GLY domain containing linker protein 3 1 0 0 0 0 259 1209 CLPTM1 cleft lip and palate associated transmembrane protein 1 0 1 0 0 0 260 1212 CLTB , light chain (Lcb) 1 0 0 0 0 261 152189 CMTM8 CKLF-like MARVEL transmembrane domain containing 8 0 0 1 0 0 262 7555 CNBP CCHC-type zinc finger, nucleic acid binding protein 0 1 0 0 0 263 1267 CNP 2',3'-cyclic nucleotide 3' phosphodiesterase 1 0 0 0 0 264 1269 CNR2 2 (macrophage) 1 0 1 0 0 265 1305 COL13A1 collagen, type XIII, alpha 1 1 0 0 0 0 266 1282 COL4A1 collagen, type IV, alpha 1 0 1 0 0 0 7962065 1 267 1285 COL4A3 collagen, type IV, alpha 3 (Goodpasture antigen) 1 0 1 0 0 7962065 268 1286 COL4A4 collagen, type IV, alpha 4 1 1 0 0 0 7962065 269 150684 COMMD1 copper metabolism (Murr1) domain containing 1 0 1 0 0 0 270 11316 COPE protein complex, subunit epsilon 0 1 0 0 0 271 50813 COPS7A COP9 constitutive photomorphogenic homolog subunit 7A (Arabidopsis) 0 0 1 0 0 272 80219 COQ10B coenzyme Q10 homolog B (S. cerevisiae) 0 0 1 0 0 273 10391 CORO2B coronin, actin binding protein, 2B 1 0 0 0 0 274 1368 CPM M 1 0 0 0 0 275 221184 CPNE2 copine II 10000 276 144402 CPNE8 copine VIII 10100 277 1387 CREBBP CREB binding protein (Rubinstein-Taybi syndrome) 0 1 0 0 0 278 1393 CRHBP corticotropin releasing hormone binding protein 0 0 0 0 1 279 51232 CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0 0 1 1 0 11084657 1 280 1396 CRIP1 cysteine-rich protein 1 (intestinal) 1 0 0 0 0 281 1397 CRIP2 cysteine-rich protein 2 1 0 0 0 0 282 64109 CRLF2 receptor-like factor 2 1 0 0 0 0 283 200186 CRTC2 CREB regulated transcription 2 1 0 0 0 0 284 64784 CRTC3 CREB regulated transcription coactivator 3 1 0 0 0 0 285 27254 CSDC2 cold shock domain containing C2, RNA binding 1 0 0 0 0 286 1457 CSNK2A1 , alpha 1 polypeptide 0 1 1 0 0 287 1465 CSRP1 cysteine and glycine-rich protein 1 0 1 0 1 0 288 10664 CTCF CCCTC-binding factor (zinc finger protein) 0 1 0 0 0 289 10217 CTDSPL CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosph 11000 290 1490 CTGF connective tissue growth factor 1 1 0 1 0 15012739 291 8727 CTNNAL1 (cadherin-associated protein), alpha-like 1 1 0 0 0 0 292 1499 CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0 1 0 0 0 12592568 293 1508 CTSB cathepsin B 10000 294 1515 CTSL2 cathepsin L2 0 1 0 0 0 15197181 295 6376 CX3CL1 chemokine (C-X3-C motif) ligand 1 1 0 1 1 0 11912255 296 6387 CXCL12 chemokine (C-X-C motif) ligand 12 (stromal cell-derived factor 1) 1 0 1 0 0 11912255 297 2920 CXCL2 chemokine (C-X-C motif) ligand 2 1 0 0 1 0 298 4283 CXCL9 chemokine (C-X-C motif) ligand 9 0 0 0 0 1 299 57007 CXCR7 chemokine (C-X-C motif) receptor 7 1 1 0 0 0 300 55787 CXorf15 chromosome X open reading frame 15 0 0 0 0 1 301 51523 CXXC5 CXXC finger 5 0 1 0 0 0 302 1727 CYB5R3 cytochrome b5 reductase 3 1 0 0 0 0 303 1535 CYBA cytochrome b-245, alpha polypeptide 0 1 0 0 0 304 26999 CYFIP2 cytoplasmic FMR1 interacting protein 2 0 1 0 0 0 305 1584 CYP11B1 cytochrome P450, family 11, subfamily B, polypeptide 1 0 0 0 0 1 306 1545 CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 1 0 0 0 0 307 57404 CYP20A1 cytochrome P450, family 20, subfamily A, polypeptide 1 1 0 0 0 0 308 1592 CYP26A1 cytochrome P450, family 26, subfamily A, polypeptide 1 1 0 0 0 0 309 1593 CYP27A1 cytochrome P450, family 27, subfamily A, polypeptide 1 1 0 0 0 0 310 1580 CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1 1 1 1 0 0 311 1595 CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1 0 1 0 0 0 312 27065 D4S234E DNA segment on chromosome 4 (unique) 234 expressed sequence 1 0 0 0 0 313 113189 D4ST1 dermatan 4 sulfotransferase 1 1 0 0 0 0 314 23500 DAAM2 dishevelled associated activator of morphogenesis 2 1 0 1 0 0 315 1602 DACH1 dachshund homolog 1 (Drosophila) 0 0 0 0 1 316 1605 DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1) 0 1 0 0 0 10793086 317 8642 DCHS1 dachsous 1 (Drosophila) 1 0 0 0 0 318 9937 DCLRE1A DNA cross-link repair 1A (PSO2 homolog, S. cerevisiae) 1 0 0 0 0 319 64858 DCLRE1B DNA cross-link repair 1B (PSO2 homolog, S. cerevisiae) 0 1 0 0 0 320 1634 DCN decorin 00010 321 23109 DDN dendrin 0 1 1 0 0 17251388 322 1650 DDOST dolichyl-diphosphooligosaccharide-protein glycosyltransferase 0 1 0 0 0 323 10521 DDX17 DEAD (Asp-Glu-Ala-Asp) box polypeptide 17 0 1 0 0 0 324 54555 DDX49 DEAD (Asp-Glu-Ala-Asp) box polypeptide 49 0 0 1 0 0 325 1666 DECR1 2,4-dienoyl CoA reductase 1, mitochondrial 0 1 0 0 0 326 8560 DEGS1 degenerative spermatocyte homolog 1, desaturase (Drosophila) 0 1 0 0 0 327 27147 DENND2A DENN/MADD domain containing 2A 1 0 0 0 0 328 163259 DENND2C DENN/MADD domain containing 2C 1 0 0 0 0 329 79139 DERL1 Der1-like domain family, member 1 0 1 0 0 0 330 1674 DES 1 0 0 0 0 2432791 331 160851 DGKH diacylglycerol kinase, eta 1 0 0 0 0 332 8525 DGKZ diacylglycerol kinase, zeta 104kDa 1 0 0 0 0 333 51635 DHRS7 dehydrogenase/reductase (SDR family) member 7 1 0 0 0 0 334 1660 DHX9 DEAH (Asp-Glu-Ala-His) box polypeptide 9 0 0 0 1 0 335 56616 DIABLO diablo homolog (Drosophila) 0 1 0 0 0 336 23151 DIP death-inducing-protein 1 0 0 0 0 337 25851 DKFZP434B03 DKFZP434B0335 protein 1 0 0 0 0 338 27123 DKK2 dickkopf homolog 2 ( laevis) 1 0 1 0 0 339 9231 DLG5 discs, large homolog 5 (Drosophila) 1 0 0 0 0 340 22839 DLGAP4 discs, large (Drosophila) homolog-associated protein 4 1 0 0 0 0 341 8788 DLK1 delta-like 1 homolog (Drosophila) 1 1 1 0 0 17332733 342 54567 DLL4 delta-like 4 (Drosophila) 1 0 0 0 0 343 3301 DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 0 1 0 0 0 344 4189 DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9 0 1 0 0 0 345 26010 DNAPTP6 DNA polymerase-transactivated protein 6 1 0 0 0 0 346 1774 DNASE1L1 deoxyribonuclease I-like 1 1 0 0 0 0 347 92737 DNER delta/notch-like EGF repeat containing 0 0 0 1 0 348 139818 dedicator of cytokinesis 11 1 0 0 0 0 349 9732 dedicator of cytokinesis 4 0 0 1 0 0 350 80005 DOCK5 dedicator of cytokinesis 5 1 0 0 0 0 351 81704 DOCK8 dedicator of cytokinesis 8 1 0 0 0 0 352 23348 dedicator of cytokinesis 9 0 0 0 0 1 353 55715 DOK4 docking protein 4 1 0 0 0 0 354 55332 DRAM damage-regulated autophagy modulator 1 0 1 0 0 355 53820 DSCR6 Down syndrome critical region gene 6 1 0 0 0 0 356 1843 DUSP1 dual specificity phosphatase 1 0 1 1 0 0 357 78986 DUSP26 dual specificity phosphatase 26 (putative) 1 0 0 0 0 358 1845 DUSP3 dual specificity phosphatase 3 (vaccinia phosphatase VH1-related) 1 0 0 0 0 359 1780 DYNC1I1 , cytoplasmic 1, intermediate chain 1 1 0 0 0 0 360 1859 DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0 1 0 0 0 361 8291 DYSF , limb girdle 2B (autosomal recessive) 1 0 1 0 0 1 362 1869 transcription factor 1 1 0 0 0 0 1 363 1879 EBF1 early B-cell factor 1 0 0 1 0 0 364 9695 EDEM1 ER degradation enhancer, mannosidase alpha-like 1 1 0 0 0 0 365 1901 EDG1 endothelial differentiation, sphingolipid G-protein-coupled receptor, 1 1 0 1 1 1 366 1903 EDG3 endothelial differentiation, sphingolipid G-protein-coupled receptor, 3 1 0 1 0 0 367 8698 EDG6 endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor, 6 1 0 0 0 0 368 1909 EDNRA receptor type A 1 0 0 0 0 369 1910 EDNRB type B 1 0 1 0 0 370 1915 EEF1A1 eukaryotic 1 alpha 1 0 1 0 0 0 371 79180 EFHD2 EF-hand domain family, member D2 1 0 0 0 0 372 1947 EFNB1 -B1 11100 373 1948 EFNB2 ephrin-B2 1 0 0 0 0 11729236 374 1950 EGF (beta-urogastrone) 1 0 0 0 0 375 51162 EGFL7 EGF-like-domain, multiple 7 1 1 1 1 0 376 1958 EGR1 early growth response 1 0 1 0 0 0 9067901 377 254102 EHBP1L1 EH domain binding protein 1-like 1 1 0 0 0 0 378 30846 EHD2 EH-domain containing 2 1 0 1 0 0 379 30845 EHD3 EH-domain containing 3 1 1 1 0 1 17251388 380 30844 EHD4 EH-domain containing 4 0 0 1 0 0 381 23741 EID1 EP300 interacting inhibitor of differentiation 1 0 0 0 1 0 382 8668 EIF3S2 eukaryotic translation initiation factor 3, subunit 2 beta, 36kDa 0 1 0 0 0 383 8665 EIF3S5 eukaryotic translation initiation factor 3, subunit 5 epsilon, 47kDa 0 0 1 0 0 384 317649 EIF4E3 eukaryotic translation initiation factor 4E family member 3 1 0 0 0 0 385 1982 EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0 1 0 1 0 386 2004 ELK3 ELK3, ETS-domain protein (SRF accessory protein 2) 1 0 0 0 0 1 387 9844 ELMO1 engulfment and cell motility 1 1 0 0 0 0 388 63916 ELMO2 engulfment and cell motility 2 1 0 0 0 0 389 51705 EMCN endomucin 1 1 1 1 1 12000719 390 10436 EMG1 EMG1 nucleolar protein homolog (S. cerevisiae) 0 1 0 0 0 391 11117 EMILIN1 elastin microfibril interfacer 1 0 0 1 0 0 392 2009 EML1 echinoderm microtubule associated protein like 1 1 0 1 0 0 393 2013 EMP2 epithelial 2 1 0 1 0 0 394 2014 EMP3 epithelial membrane protein 3 1 0 1 0 0 395 326342 EMR4 egf-like module containing, -like, -like 4 1 0 0 0 0 396 8507 ENC1 ectodermal-neural cortex (with BTB-like domain) 1 0 0 0 0 397 2022 ENG endoglin (Osler-Rendu-Weber syndrome 1) 1 1 1 1 1 9052849 1 398 2028 ENPEP (aminopeptidase A) 0 1 0 1 0 7174362 399 2034 EPAS1 endothelial PAS domain protein 1 1 0 0 0 1 12660327 400 1969 EPHA2 EPH receptor A2 0 0 1 0 0 401 2047 EPHB1 EPH receptor B1 1 0 0 0 0 402 2052 EPHX1 epoxide 1, microsomal (xenobiotic) 1 0 0 0 0 403 22905 EPN2 epsin 2 10000 404 2057 EPOR receptor 1 0 0 0 0 405 157697 ERICH1 glutamate-rich 1 0 0 1 0 0 406 54206 ERRFI1 ERBB receptor feedback inhibitor 1 0 1 0 0 0 407 90952 ESAM endothelial cell adhesion molecule 1 0 0 0 0 408 11082 ESM1 endothelial cell-specific molecule 1 1 1 1 0 1 409 2109 ETFB electron-transfer-flavoprotein, beta polypeptide 0 1 0 0 0 410 2113 ETS1 v-ets erythroblastosis virus E26 oncogene homolog 1 (avian) 1 1 1 0 0 15253715 411 2114 ETS2 v-ets erythroblastosis virus E26 oncogene homolog 2 (avian) 1 0 0 0 0 412 2122 EVI1 ecotropic viral integration site 1 0 1 1 0 0 413 90332 EXOC3L2 exocyst complex component 3-like 2 0 0 0 1 0 414 149371 EXOC8 exocyst complex component 8 0 1 0 0 0 415 2149 F2R coagulation factor II (thrombin) receptor 1 1 1 0 0 416 9002 F2RL3 coagulation factor II (thrombin) receptor-like 3 1 0 0 0 0 417 2152 F3 coagulation factor III (thromboplastin, tissue factor) 0 1 0 0 0 418 2167 FABP4 fatty acid binding protein 4, adipocyte 0 0 1 0 0 419 144347 FAM101A family with sequence similarity 101, member A 1 0 1 0 0 420 92689 FAM114A1 family with sequence similarity 114, member A1 1 0 0 0 0 421 64855 FAM129B family with sequence similarity 129, member B 1 0 1 0 0 422 220965 FAM13C1 family with sequence similarity 13, member C1 1 0 0 0 0 423 54801 FAM29A family with sequence similarity 29, member A 0 0 1 0 0 424 131583 FAM43A family with sequence similarity 43, member A 0 0 1 0 0 425 169966 FAM46D family with sequence similarity 46, member D 0 0 0 1 0 426 81553 FAM49A family with sequence similarity 49, member A 1 0 0 0 0 427 23344 FAM62A family with sequence similarity 62 (C2 domain containing), member A 1 0 0 0 0 428 79567 FAM65A family with sequence similarity 65, member A 1 0 1 1 0 17251388 429 127262 FAM79A family with sequence similarity 79, member A 0 1 0 0 0 430 145773 FAM81A family with sequence similarity 81, member A 0 1 0 0 0 431 375061 FAM89A family with sequence similarity 89, member A 0 0 0 0 1 432 355 FAS Fas (TNF receptor superfamily, member 6) 1 0 0 0 0 433 2195 FAT FAT tumor suppressor homolog 1 (Drosophila) 0 0 0 1 0 8586420 434 26270 FBXO6 F-box protein 6 1 0 0 0 0 435 26269 FBXO8 F-box protein 8 0 1 0 0 0 436 8547 FCN3 ficolin (collagen/fibrinogen domain containing) 3 (Hakata antigen) 0 0 0 1 1 437 2242 FES 1 0 0 0 0 438 55785 FGD6 FYVE, RhoGEF and PH domain containing 6 1 0 0 0 0 439 2246 FGF1 1 (acidic) 1 0 0 1 0 440 9982 FGFBP1 fibroblast growth factor binding protein 1 1 1 0 0 0 441 10875 FGL2 fibrinogen-like 2 1 0 0 0 0 442 2273 FHL1 four and a half LIM domains 1 0 0 0 1 0 443 2274 FHL2 four and a half LIM domains 2 1 0 1 0 0 444 29109 FHOD1 formin homology 2 domain containing 1 0 0 1 0 0 445 27145 FILIP1 filamin A interacting protein 1 1 0 0 0 0 446 60681 FKBP10 FK506 binding protein 10, 65 kDa 1 0 0 0 0 447 51661 FKBP7 FK506 binding protein 7 1 0 1 0 0 448 11328 FKBP9 FK506 binding protein 9, 63 kDa 0 0 0 1 0 449 2313 FLI1 Friend leukemia virus integration 1 1 0 1 0 0 450 441027 FLJ12993 hypothetical LOC441027 0 0 1 0 0 451 80221 FLJ20920 hypothetical protein FLJ20920 0 0 0 0 1 452 149076 FLJ25476 FLJ25476 protein 0 1 0 0 0 453 127703 FLJ38984 hypothetical protein FLJ38984 1 0 0 0 0 454 353116 FLJ39378 hypothetical protein FLJ39378 1 0 0 0 0 455 2316 FLNA filamin A, alpha (actin binding protein 280) 0 0 0 1 0 1 456 2321 FLT1 fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular perme 1 0 1 0 1 7864162 457 2324 FLT4 fms-related tyrosine kinase 4 1 0 0 0 1 12019293 458 56776 FMN2 formin 2 00010 459 114793 FMNL2 formin-like 2 00100 460 23048 FNBP1 formin binding protein 1 1 0 0 0 0 461 2339 FNTA farnesyltransferase, CAAX box, alpha 0 1 0 0 0 462 2353 FOS v-fos FBJ murine osteosarcoma viral oncogene homolog 0 1 0 0 0 9681709 463 2296 FOXC1 0 1 1 1 0 464 2303 FOXC2 forkhead box C2 (MFH-1, mesenchyme forkhead 1) 1 0 1 0 0 8325367 465 122786 FRMD6 FERM domain containing 6 1 0 0 0 1 466 2495 FTH1 ferritin, heavy polypeptide 1 0 1 0 0 0 467 84750 FUT10 fucosyltransferase 10 (alpha (1,3) fucosyltransferase) 1 0 0 0 0 468 53827 FXYD5 FXYD domain containing ion transport regulator 5 1 0 1 0 0 469 53826 FXYD6 FXYD domain containing ion transport regulator 6 1 0 0 0 0 470 2534 FYN FYN oncogene related to SRC, FGR, YES 1 0 1 0 0 471 2535 FZD2 homolog 2 (Drosophila) 1 0 0 0 0 472 9846 GAB2 GRB2-associated binding protein 2 1 0 0 0 0 473 2557 GABRA4 gamma-aminobutyric acid (GABA) A receptor, alpha 4 1 0 1 0 0 474 2560 GABRB1 gamma-aminobutyric acid (GABA) A receptor, beta 1 1 0 0 0 0 475 1647 GADD45A growth arrest and DNA-damage-inducible, alpha 1 0 1 0 0 476 4616 GADD45B growth arrest and DNA-damage-inducible, beta 0 0 0 1 0 477 10912 GADD45G growth arrest and DNA-damage-inducible, gamma 1 0 1 0 0 478 55568 GALNT10 UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransfe 11100 479 2625 GATA3 GATA binding protein 3 1 0 0 0 0 7956841 480 140628 GATA5 GATA binding protein 5 1 0 0 0 0 481 54815 GATAD2A GATA zinc finger domain containing 2A 1 0 0 0 0 482 145781 Gcom1 GRINL1A combined protein 1 0 0 0 0 483 2662 GDF10 growth differentiation factor 10 1 0 0 0 0 484 8200 GDF5 growth differentiation factor 5 (cartilage-derived morphogenetic protein-1) 1 0 1 0 0 485 81544 GDPD5 glycerophosphodiester phosphodiesterase domain containing 5 1 0 0 0 0 486 8987 GENX-3414 genethonin 1 10000 487 81577 GFOD2 glucose-fructose domain containing 2 1 0 0 0 0 488 2687 GGTLA1 gamma-glutamyltransferase-like activity 1 1 0 0 0 0 489 170575 GIMAP1 GTPase, IMAP family member 1 1 0 0 0 0 490 55303 GIMAP4 GTPase, IMAP family member 4 1 1 1 0 0 491 55340 GIMAP5 GTPase, IMAP family member 5 1 0 1 0 0 492 474344 GIMAP6 GTPase, IMAP family member 6 1 0 0 0 1 493 155038 GIMAP8 GTPase, IMAP family member 8 0 0 1 0 0 494 9815 GIT2 G protein-coupled receptor kinase interactor 2 1 0 0 0 0 495 2697 GJA1 , alpha 1, 43kDa 0 0 0 1 0 12414508 496 2700 GJA3 gap junction protein, alpha 3, 46kDa 1 0 0 0 0 497 2701 GJA4 gap junction protein, alpha 4, 37kDa 1 0 0 0 0 498 2702 GJA5 gap junction protein, alpha 5, 40kDa 1 0 1 1 1 15094354 499 113263 GLCCI1 glucocorticoid induced transcript 1 1 0 1 0 0 500 2734 GLG1 protein 1 0 1 0 0 0 501 9535 GMFG , gamma 1 0 0 0 0 502 2771 GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptid 11100 503 2776 GNAQ guanine nucleotide binding protein (G protein), q polypeptide 1 0 0 0 0 504 59345 GNB4 guanine nucleotide binding protein (G protein), beta polypeptide 4 1 0 0 0 0 505 2791 GNG11 guanine nucleotide binding protein (G protein), gamma 11 1 0 0 1 1 506 2793 GNGT2 guanine nucleotide binding protein (G protein), gamma transducing activity polyp 10000 507 54552 GNL3L guanine nucleotide binding protein-like 3 (nucleolar)-like 0 1 0 0 0 508 51280 GOLPH2 golgi phosphoprotein 2 1 0 0 0 0 509 64083 GOLPH3 golgi phosphoprotein 3 (coat-protein) 0 1 0 0 0 510 27333 GOLPH4 golgi phosphoprotein 4 1 0 1 0 0 511 60313 GPBP1L1 GC-rich binding protein 1-like 1 0 1 0 0 0 512 2817 GPC1 glypican 1 10000 513 2824 GPM6B glycoprotein M6B 1 0 0 0 0 514 221395 GPR116 G protein-coupled receptor 116 1 1 1 0 0 17332733 515 166647 GPR125 G protein-coupled receptor 125 0 1 0 0 0 516 115330 GPR146 G protein-coupled receptor 146 1 0 0 0 0 517 79971 GPR177 G protein-coupled receptor 177 0 1 0 0 0 518 2846 GPR23 G protein-coupled receptor 23 1 0 0 0 0 519 2828 GPR4 G protein-coupled receptor 4 1 0 0 0 0 520 26086 GPSM1 G-protein signalling modulator 1 (AGS3-like, C. elegans) 1 0 0 0 0 521 63940 GPSM3 G-protein signalling modulator 3 (AGS3-like, C. elegans) 1 0 1 0 0 522 2876 GPX1 glutathione peroxidase 1 0 1 0 0 0 523 10750 GRAP GRB2-related adaptor protein 1 0 0 0 0 524 160622 GRASP GRP1 (general receptor for phosphoinositides 1)-associated scaffold protein 1 0 0 0 0 525 2869 GRK5 G protein-coupled receptor kinase 5 1 0 0 0 0 526 79792 GSDMDC1 gasdermin domain containing 1 1 0 0 0 0 527 2934 GSN (amyloidosis, Finnish type) 0 1 0 0 0 528 2983 GUCY1B3 1, soluble, beta 3 1 0 0 0 0 529 3032 HADHB hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A /enoy 01000 530 1404 HAPLN1 hyaluronan and proteoglycan link protein 1 1 0 0 0 0 531 81532 HCCA2 HCCA2 protein 1 0 0 0 0 532 339799 hCG_15200 hCG15200 00100 533 648000 hCG_2015956 hCG2015956 01000 534 51564 HDAC7A 7A 1 0 0 0 0 535 3068 HDGF hepatoma-derived growth factor (high-mobility group protein 1-like) 0 1 0 0 0 9739055 536 84717 HDGF2 hepatoma-derived growth factor-related protein 2 1 0 0 0 0 537 143279 HECTD2 HECT domain containing 2 1 0 0 0 0 538 57493 HEG1 HEG homolog 1 () 0 1 0 0 0 539 55502 HES6 hairy and enhancer of split 6 (Drosophila) 0 1 0 0 0 540 10614 HEXIM1 hexamethylene bis-acetamide inducible 1 0 0 1 0 0 541 23462 HEY1 hairy/enhancer-of-split related with YRPW motif 1 1 0 0 0 0 542 23493 HEY2 hairy/enhancer-of-split related with YRPW motif 2 1 0 0 0 0 543 55733 HHAT hedgehog acyltransferase 1 0 0 0 0 544 3087 HHEX hematopoietically expressed 1 0 0 0 1 545 29923 HIG2 hypoxia-inducible protein 2 1 0 1 0 0 546 3092 HIP1 huntingtin interacting protein 1 1 1 0 0 0 547 204851 HIPK1 homeodomain interacting protein kinase 1 0 1 0 0 0 548 7290 HIRA HIR histone cell cycle regulation defective homolog A (S. cerevisiae) 0 1 0 0 0 549 3097 HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 1 0 0 0 0 550 3122 HLA-DRA major histocompatibility complex, class II, DR alpha 0 0 0 1 0 1721044 551 3123 HLA-DRB1 major histocompatibility complex, class II, DR beta 1 0 0 0 0 1 552 3133 HLA-E major histocompatibility complex, class I, E 1 0 0 1 0 553 3142 HLX1 H2.0-like homeobox 1 (Drosophila) 1 0 1 0 0 554 3146 HMGB1 high-mobility group box 1 0 1 0 0 0 555 3149 HMGB3 high-mobility group box 3 0 1 0 0 0 556 10949 HNRPA0 heterogeneous nuclear ribonucleoprotein A0 0 1 0 0 0 557 220988 HNRPA3 heterogeneous nuclear ribonucleoprotein A3 0 1 0 0 0 558 3182 HNRPAB heterogeneous nuclear ribonucleoprotein A/B 0 1 0 0 0 559 3188 HNRPH2 heterogeneous nuclear ribonucleoprotein H2 (H') 0 1 0 0 0 560 84525 HOP homeodomain-only protein 1 0 0 0 0 561 3198 HOXA1 10000 562 3221 HOXC4 homeobox C4 10000 563 3250 HPR -related protein 1 0 0 0 0 564 9957 HS3ST1 (glucosamine) 3-O-sulfotransferase 1 1 0 0 0 0 565 9955 HS3ST3A1 heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1 1 0 0 0 0 566 9953 HS3ST3B1 heparan sulfate (glucosamine) 3-O-sulfotransferase 3B1 0 0 1 0 1 567 64711 HS3ST6 heparan sulfate (glucosamine) 3-O-sulfotransferase 6 1 0 1 0 0 568 3320 HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0 1 0 0 0 569 3326 HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0 1 0 0 0 570 259217 HSPA12A heat shock 70kDa protein 12A 1 0 0 0 0 571 116835 HSPA12B heat shock 70kD protein 12B 1 0 0 0 0 572 3315 HSPB1 heat shock 27kDa protein 1 1 0 1 0 0 8675679 573 26353 HSPB8 heat shock 22kDa protein 8 1 0 0 0 0 574 29094 HSPC159 galectin-related protein 1 0 0 0 0 575 5654 HTRA1 HtrA serine peptidase 1 1 0 1 1 0 576 255488 IBRDC2 IBR domain containing 2 1 0 0 0 0 577 3384 ICAM2 intercellular adhesion molecule 2 1 1 1 0 0 9565596 578 3397 ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein 0 0 1 1 0 579 3399 ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein 0 1 1 0 0 580 51278 IER5 immediate early response 5 1 1 1 0 0 581 3428 IFI16 interferon, gamma-inducible protein 16 1 0 1 0 0 582 3429 IFI27 interferon, alpha-inducible protein 27 1 0 0 0 0 583 8519 IFITM1 interferon induced transmembrane protein 1 (9-27) 0 0 0 1 0 584 10410 IFITM3 interferon induced transmembrane protein 3 (1-8U) 1 0 1 1 0 585 3485 IGFBP2 insulin-like growth factor binding protein 2, 36kDa 0 0 0 1 0 7532247 586 3488 IGFBP5 insulin-like growth factor binding protein 5 1 1 1 1 1 9324049 587 3490 IGFBP7 insulin-like growth factor binding protein 7 0 1 0 1 0 17332733 588 3588 IL10RB 10 receptor, beta 0 1 0 0 0 589 3606 IL18 interleukin 18 (interferon-gamma-inducing factor) 1 0 0 0 0 590 9173 IL1RL1 interleukin 1 receptor-like 1 0 0 0 1 1 591 3561 IL2RG interleukin 2 receptor, gamma (severe combined immunodeficiency) 1 0 0 0 0 592 3569 IL6 interleukin 6 (interferon, beta 2) 1 0 0 0 0 593 3572 IL6ST interleukin 6 signal transducer (gp130, oncostatin M receptor) 1 0 0 0 1 594 3608 ILF2 interleukin enhancer binding factor 2, 45kDa 1 0 0 0 0 595 196294 IMMP1L IMP1 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0 1 0 0 0 596 55272 IMP3 IMP3, U3 small nucleolar ribonucleoprotein, homolog (yeast) 0 0 1 0 0 597 3614 IMPDH1 IMP (inosine monophosphate) dehydrogenase 1 1 0 0 0 0 598 3621 ING1 inhibitor of growth family, member 1 0 1 0 0 0 599 3625 INHBB inhibin, beta B (activin AB beta polypeptide) 1 0 0 0 0 600 3632 INPP5A inositol polyphosphate-5-phosphatase, 40kDa 1 0 0 0 0 601 3635 INPP5D inositol polyphosphate-5-phosphatase, 145kDa 1 0 0 0 0 602 51194 IPO11 importin 11 10000 603 3659 IRF1 interferon regulatory factor 1 1 0 1 0 0 604 3665 IRF7 interferon regulatory factor 7 1 0 0 0 0 605 9636 ISG15 ISG15 ubiquitin-like modifier 0 0 0 1 0 606 3675 ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 1 0 0 1 0 2144000 607 3678 ITGA5 integrin, alpha 5 ( receptor, alpha polypeptide) 1 0 0 0 0 2144000 608 8516 ITGA8 integrin, alpha 8 1 1 1 0 0 10504498 609 3680 ITGA9 integrin, alpha 9 1 0 0 0 0 610 3688 ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes M 1 1 0 1 0 10504498 1 611 9270 ITGB1BP1 binding protein 1 1 0 0 0 0 612 3693 ITGB5 integrin, beta 5 1 0 1 0 0 8821033 1 613 81618 ITM2C integral membrane protein 2C 0 1 0 0 0 614 3707 ITPKB inositol 1,4,5-trisphosphate 3-kinase B 1 0 1 0 0 615 3710 ITPR3 inositol 1,4,5-triphosphate receptor, type 3 1 0 0 0 0 616 3714 JAG2 jagged 2 10000 617 3718 JAK3 3 (a protein tyrosine kinase, leukocyte) 1 0 1 0 0 9099938 618 58494 JAM2 junctional adhesion molecule 2 1 0 0 0 0 619 5927 JARID1A jumonji, AT rich interactive domain 1A 0 1 0 0 0 620 3725 JUN jun oncogene 0 1 0 0 0 9131421 621 3726 JUNB jun B proto-oncogene 0 0 1 0 0 1 622 10376 K-ALPHA-1 alpha 01000 623 26251 KCNG2 potassium voltage-gated channel, subfamily G, member 2 0 0 1 0 0 624 3764 KCNJ8 potassium inwardly-rectifying channel, subfamily J, member 8 1 0 0 0 0 625 83892 KCTD10 tetramerisation domain containing 10 1 0 0 0 0 626 222658 KCTD20 potassium channel tetramerisation domain containing 20 1 0 0 0 0 627 3791 KDR kinase insert domain receptor (a type III receptor tyrosine kinase) 1 1 1 0 0 7864162 1 628 9768 KIAA0101 KIAA0101 01000 629 9778 KIAA0232 KIAA0232 gene product 0 1 0 0 0 630 9827 KIAA0258 KIAA0258 10000 631 9710 KIAA0355 KIAA0355 11000 632 9764 KIAA0513 KIAA0513 10100 633 23255 KIAA0802 KIAA0802 10100 634 23053 KIAA0913 KIAA0913 01000 635 55704 KIAA1212 KIAA1212 10000 636 27143 KIAA1274 KIAA1274 10000 637 57700 KIAA1600 KIAA1600 10000 638 85450 KIAA1754 KIAA1754 10000 639 165215 KIAA1946 KIAA1946 10000 640 170954 KIAA1949 KIAA1949 10100 641 79834 KIAA2002 KIAA2002 protein 1 0 0 0 0 642 23095 KIF1B family member 1B 1 0 0 0 0 643 55243 KIRREL kin of IRRE like (Drosophila) 0 0 0 1 0 644 4254 KITLG KIT ligand 10000 645 51621 KLF13 Kruppel-like factor 13 1 0 0 0 0 646 10365 KLF2 Kruppel-like factor 2 () 1 0 0 1 0 647 1316 KLF6 Kruppel-like factor 6 0 1 0 0 0 11274234 648 8609 KLF7 Kruppel-like factor 7 (ubiquitous) 1 0 0 0 0 649 11275 KLHL2 kelch-like 2, Mayven (Drosophila) 0 1 0 0 0 650 354 KLK3 kallikrein-related peptidase 3 0 0 0 0 1 651 9622 KLK4 kallikrein-related peptidase 4 0 0 0 0 1 652 5653 KLK6 kallikrein-related peptidase 6 0 0 0 0 1 653 11202 KLK8 kallikrein-related peptidase 8 1 0 0 0 0 654 3831 KNS2 kinesin 2 10000 655 83999 KREMEN1 kringle containing transmembrane protein 1 1 0 0 0 0 656 8844 KSR1 kinase suppressor of ras 1 1 0 0 0 0 657 3913 LAMB2 , beta 2 (laminin S) 1 0 1 1 0 7670489 1 658 3915 LAMC1 laminin, gamma 1 (formerly LAMB2) 0 1 0 0 0 12015298 1 659 3916 LAMP1 lysosomal-associated membrane protein 1 0 1 0 0 0 660 9741 LAPTM4A lysosomal-associated protein transmembrane 4 alpha 0 1 0 0 0 661 23395 LARS2 leucyl-tRNA synthetase 2, mitochondrial 0 1 0 0 0 662 26524 LATS2 LATS, large tumor suppressor, homolog 2 (Drosophila) 1 0 0 0 0 663 3937 LCP2 cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kD 10000 664 9079 LDB2 LIM domain binding 2 1 0 1 0 1 665 26119 LDLRAP1 low density lipoprotein receptor adaptor protein 1 1 0 0 0 0 1 666 10536 LEPREL2 leprecan-like 2 1 0 0 0 0 667 54741 LEPROT overlapping transcript 0 0 0 1 0 668 3956 LGALS1 lectin, galactoside-binding, soluble, 1 (galectin 1) 0 0 0 1 0 1 669 3965 LGALS9 lectin, galactoside-binding, soluble, 9 (galectin 9) 1 0 1 0 0 9153289 670 9211 LGI1 leucine-rich, glioma inactivated 1 1 0 0 0 0 671 55679 LIMS2 LIM and senescent cell antigen-like domains 2 1 0 0 0 0 672 29995 LMCD1 LIM and cysteine-rich domains 1 1 0 1 0 0 673 4000 LMNA A/C 10000 674 84823 LMNB2 10000 675 4004 LMO1 LIM domain only 1 (rhombotin 1) 1 0 0 0 0 676 4005 LMO2 LIM domain only 2 (rhombotin-like 1) 1 0 1 0 1 677 152573 LOC152573 hypothetical protein BC012029 0 0 1 0 0 678 286191 LOC286191 hypothetical protein LOC286191 0 0 0 0 1 679 338328 LOC338328 high density lipoprotein-binding protein 1 1 1 0 1 680 387934 LOC387934 similar to Fatty acid-binding protein, epidermal (E-FABP) (Psoriasis-associated f 10000 681 440087 LOC440087 hypothetical gene supported by AK092637 0 0 1 0 0 682 653464 LOC653464 similar to SLIT-ROBO Rho GTPase-activating protein 2 (srGAP2) (Formin-bindin 00011 683 653560 LOC653560 similar to cytokine receptor-like factor 2 isoform 1 1 0 0 0 0 684 653566 LOC653566 similar to Signal peptidase complex subunit 2 (Microsomal signal peptidase 25 k 01100 685 653653 LOC653653 similar to adaptor-related protein complex 1 sigma 2 subunit 1 0 0 0 0 686 728198 LOC728198 similar to transcription associated factor 9B 1 0 0 0 0 687 729533 LOC729533 similar to family with sequence similarity 72, member A 1 0 0 0 0 688 729871 LOC729871 similar to aortic preferentially expressed gene 1 1 0 0 0 0 689 90120 LOC90120 hypothetical gene supported by AK023162 0 1 0 0 0 690 4014 LOR loricrin 10000 691 4016 LOXL1 lysyl oxidase-like 1 1 0 0 0 0 692 4017 LOXL2 lysyl oxidase-like 2 0 0 1 0 0 693 84695 LOXL3 lysyl oxidase-like 3 1 0 0 0 0 694 9663 LPIN2 lipin 2 10000 695 4023 LPL lipoprotein lipase 1 0 1 0 0 696 23143 LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1 1 0 0 0 0 697 131578 LRRC15 leucine rich repeat containing 15 1 0 0 0 0 698 2615 LRRC32 leucine rich repeat containing 32 0 0 0 1 0 699 375387 LRRC33 leucine rich repeat containing 33 1 0 0 0 0 700 116135 LRRC3B leucine rich repeat containing 3B 1 0 0 0 0 701 54839 LRRC49 leucine rich repeat containing 49 1 0 1 0 0 702 84230 LRRC8C leucine rich repeat containing 8 family, member C 1 0 0 0 0 703 51691 LSM8 LSM8 homolog, U6 small nuclear RNA associated (S. cerevisiae) 1 0 0 0 0 704 51631 LUC7L2 LUC7-like 2 (S. cerevisiae) 0 1 1 0 0 705 7798 LUZP1 leucine zipper protein 1 1 0 0 0 0 706 4067 LYN v-yes-1 Yamaguchi sarcoma viral related oncogene homolog 1 0 0 0 0 1 707 4069 LYZ lysozyme (renal amyloidosis) 0 0 0 1 0 708 9935 MAFB v- musculoaponeurotic fibrosarcoma oncogene homolog B (avian) 1 1 0 1 0 10860830 709 9863 MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0 0 1 0 1 710 378938 MALAT1 metastasis associated lung adenocarcinoma transcript 1 (non-coding RNA) 0 0 0 0 1 711 256691 MAMDC2 MAM domain containing 2 1 0 0 0 0 712 9794 MAML1 mastermind-like 1 (Drosophila) 1 0 0 0 0 713 4121 MAN1A1 mannosidase, alpha, class 1A, member 1 1 0 0 0 0 714 57134 MAN1C1 mannosidase, alpha, class 1C, member 1 1 0 0 0 0 715 4123 MAN2C1 mannosidase, alpha, class 2C, member 1 0 0 0 1 0 716 4128 MAOA monoamine oxidase A 0 1 0 0 0 717 254042 MAP1D methionine aminopeptidase 1D 0 0 1 0 0 718 4215 MAP3K3 mitogen-activated protein kinase kinase kinase 3 1 0 0 0 0 719 1326 MAP3K8 mitogen-activated protein kinase kinase kinase 8 1 0 0 0 0 720 4134 MAP4 microtubule-associated protein 4 1 1 0 0 0 721 5871 MAP4K2 mitogen-activated protein kinase kinase kinase kinase 2 1 0 0 0 0 722 9448 MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 1 0 0 0 0 723 55700 MAP7D1 MAP7 domain containing 1 1 0 0 0 0 724 5600 MAPK11 mitogen-activated protein kinase 11 1 0 0 0 0 725 6300 MAPK12 mitogen-activated protein kinase 12 1 0 1 0 0 726 4139 MARK1 MAP/microtubule affinity-regulating kinase 1 1 0 0 0 0 727 57787 MARK4 MAP/microtubule affinity-regulating kinase 4 1 0 0 0 0 728 83742 MARVELD1 MARVEL domain containing 1 1 0 1 0 0 729 53615 MBD3 methyl-CpG binding domain protein 3 0 1 0 0 0 730 55796 MBNL3 muscleblind-like 3 (Drosophila) 1 0 0 0 0 731 4162 MCAM melanoma cell adhesion molecule 1 1 0 0 0 17332733 1 732 4170 MCL1 myeloid cell leukemia sequence 1 (BCL2-related) 0 1 0 0 0 17332733 1 733 29969 MDFIC MyoD family inhibitor domain containing 1 0 1 0 0 734 4204 MECP2 methyl CpG binding protein 2 (Rett syndrome) 0 0 1 0 0 735 51102 MECR mitochondrial trans-2-enoyl-CoA reductase 0 0 0 0 1 736 84246 MED10 of RNA polymerase II transcription, subunit 10 homolog (NUT2, S. cere 01000 737 4208 MEF2C MADS box transcription enhancer factor 2, polypeptide C (myocyte enhancer fac 10100 738 4212 MEIS2 Meis homeobox 2 1 0 1 0 0 1 739 4222 MEOX1 mesenchyme homeobox 1 1 0 1 0 0 740 10461 MERTK c-mer proto-oncogene tyrosine kinase 1 0 0 0 0 741 59274 MESDC1 mesoderm development candidate 1 0 0 1 0 0 742 4232 MEST mesoderm specific transcript homolog (mouse) 1 0 1 0 0 11934706 743 284207 METRNL meteorin, glial cell differentiation regulator-like 1 0 0 0 0 744 4240 MFGE8 milk fat globule-EGF factor 8 protein 1 0 1 0 0 745 4242 MFNG MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase 1 0 0 0 0 746 4247 MGAT2 mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase 0 1 0 0 0 747 4249 MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 1 0 0 0 0 748 84792 MGC12966 hypothetical protein LOC84792 1 0 0 0 0 749 84856 MGC16291 hypothetical protein MGC16291 0 0 0 0 1 750 65998 MGC3032 hypothetical protein MGC3032 1 0 0 0 0 751 169166 MGC39715 hypothetical protein MGC39715 0 0 1 0 0 752 257415 MGC40405 hypothetical protein MGC40405 0 0 0 0 1 753 343990 MGC42367 similar to 2010300C02Rik protein 1 0 0 0 0 754 11343 MGLL monoglyceride lipase 1 0 0 0 0 755 4256 MGP matrix Gla protein 0 0 0 1 0 756 64780 MICAL1 microtubule associated monoxygenase, calponin and LIM domain containing 1 1 0 0 0 0 757 4311 MME membrane metallo-endopeptidase (neutral endopeptidase, ) 0 0 0 1 0 758 4323 MMP14 matrix metallopeptidase 14 (membrane-inserted) 1 0 0 0 0 759 4324 MMP15 matrix metallopeptidase 15 (membrane-inserted) 1 0 0 0 0 760 4326 MMP17 matrix metallopeptidase 17 (membrane-inserted) 1 0 1 0 0 761 8510 MMP23B matrix metallopeptidase 23B 1 0 1 0 0 762 79812 MMRN2 multimerin 2 11100 763 4330 MN1 meningioma (disrupted in balanced translocation) 1 1 0 0 0 0 1 764 10933 MORF4L1 mortality factor 4 like 1 0 1 0 0 0 765 4356 MPP3 membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3) 1 0 0 0 0 766 64398 MPP5 membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5) 0 1 1 1 0 767 4360 MRC1 , C type 1 0 1 1 0 0 768 414308 MRC1L1 mannose receptor, C type 1-like 1 0 1 1 0 0 769 9902 MRC2 mannose receptor, C type 2 1 0 1 0 0 770 10627 MRCL3 myosin regulatory light chain MRCL3 0 1 0 0 0 1 771 114932 MRFAP1L1 Morf4 family associated protein 1-like 1 0 1 0 0 0 772 219928 MRGPRF MAS-related GPR, member F 1 0 0 1 0 773 23164 M-RIP myosin phosphatase-Rho interacting protein 1 0 0 0 0 774 51069 MRPL2 mitochondrial ribosomal protein L2 0 1 0 0 0 775 64960 MRPS15 mitochondrial ribosomal protein S15 0 1 0 0 0 776 10335 MRVI1 murine retrovirus integration site 1 homolog 1 0 0 0 0 777 4478 MSN moesin 0 1 0 0 0 8647942 778 114825 MST101 MSTP101 01000 779 22823 MTF2 metal response element binding transcription factor 2 1 0 0 0 0 780 9788 MTSS1 metastasis suppressor 1 1 1 0 0 1 781 57509 MTUS1 mitochondrial tumor suppressor 1 1 0 0 0 0 782 389125 MUSTN1 musculoskeletal, embryonic nuclear protein 1 1 0 0 0 0 783 9961 MVP 1 0 0 0 0 784 10608 MXD4 MAX dimerization protein 4 1 0 0 0 0 785 54587 MXRA8 matrix-remodelling associated 8 1 0 1 0 0 786 26292 MYCBP c- binding protein 0 1 0 0 0 787 4613 MYCN v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian) 1 0 0 0 0 788 80177 MYCT1 myc target 1 10100 789 58498 MYL7 myosin, light chain 7, regulatory 1 0 0 0 0 790 10398 MYL9 myosin, light chain 9, regulatory 1 0 0 1 0 791 29116 MYLIP myosin regulatory light chain interacting protein 1 0 1 0 0 792 4638 MYLK myosin, light chain kinase 1 0 1 0 0 793 4651 MYO10 myosin X 00100 794 4641 MYO1C myosin IC 11000 795 4642 MYO1D myosin ID 11100 796 4643 MYO1E myosin IE 10110 797 93649 MYOCD myocardin 10000 798 8736 MYOM1 myomesin 1 (skelemin) 185kDa 1 0 0 0 0 799 9172 MYOM2 myomesin (M-protein) 2, 165kDa 0 0 1 0 0 800 4664 NAB1 NGFI-A binding protein 1 (EGR1 binding protein 1) 1 0 0 0 0 801 4665 NAB2 NGFI-A binding protein 2 (EGR1 binding protein 2) 1 0 1 0 0 802 4673 NAP1L1 nucleosome assembly protein 1-like 1 0 1 1 0 0 803 93100 NAPRT1 nicotinate phosphoribosyltransferase domain containing 1 0 1 0 0 0 804 79731 NARS2 asparaginyl-tRNA synthetase 2 (mitochondrial)(putative) 0 0 1 0 0 805 4681 NBL1 neuroblastoma, suppression of tumorigenicity 1 1 0 1 0 0 806 4688 NCF2 neutrophil cytosolic factor 2 (65kDa, chronic granulomatous disease, autosomal 1 1 1 0 0 14514646 807 8440 NCK2 NCK adaptor protein 2 1 0 0 0 0 808 57447 NDRG2 NDRG family member 2 0 0 0 1 0 809 56901 NDUFA4L2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2 1 0 0 0 0 810 4753 NELL2 NEL-like 2 (chicken) 0 0 1 0 0 811 10763 NES 11101 812 23114 NFASC neurofascin homolog (chicken) 0 0 0 0 1 813 4772 NFATC1 nuclear factor of activated T-cells, cytoplasmic, -dependent 1 1 0 0 0 0 1 814 4782 NFIC /C (CCAAT-binding transcription factor) 1 0 0 0 0 815 4783 NFIL3 nuclear factor, interleukin 3 regulated 1 0 0 0 0 816 4791 NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) 1 0 0 0 0 817 4800 NFYA nuclear transcription factor Y, alpha 1 0 0 0 0 818 4803 NGFB , beta polypeptide 1 0 0 0 0 819 4811 NID1 nidogen 1 1 1 1 0 0 1745013 820 22795 NID2 nidogen 2 (osteonidogen) 1 0 1 0 0 12215539 821 4828 NMB neuromedin B 10000 822 64318 NOC3L nucleolar complex associated 3 homolog (S. cerevisiae) 0 0 0 0 1 823 51406 NOL7 nucleolar protein 7, 27kDa 0 0 1 0 0 824 4846 NOS3 nitric oxide synthase 3 (endothelial cell) 1 0 1 0 0 9867209 1 825 115677 NOSTRIN nitric oxide synthase trafficker 0 0 1 1 1 826 4851 NOTCH1 Notch homolog 1, translocation-associated (Drosophila) 1 0 1 0 0 15499562 827 4855 NOTCH4 Notch homolog 4 (Drosophila) 1 0 0 0 0 15499562 828 4868 NPHS1 nephrosis 1, congenital, Finnish type (nephrin) 1 1 1 0 0 10393930 829 7827 NPHS2 nephrosis 2, idiopathic, steroid-resistant (podocin) 1 1 1 1 0 10742096 830 255743 NPNT nephronectin 00010 831 4881 NPR1 natriuretic receptor A/guanylate cyclase A (atrionatriuretic peptide recep 1 0 0 0 0 832 4883 NPR3 natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide recep 11100 833 1728 NQO1 NAD(P)H dehydrogenase, quinone 1 0 0 0 1 0 12588957 834 7182 NR2C2 subfamily 2, group C, member 2 0 0 1 0 0 835 7025 NR2F1 nuclear receptor subfamily 2, group F, member 1 1 0 0 0 0 836 4929 NR4A2 nuclear receptor subfamily 4, group A, member 2 1 0 0 0 0 837 8013 NR4A3 nuclear receptor subfamily 4, group A, member 3 1 0 0 0 0 838 4900 NRGN neurogranin (protein kinase C substrate, RC3) 0 0 0 1 1 839 83714 NRIP2 nuclear receptor interacting protein 2 1 0 0 0 0 840 8829 NRP1 1 1 1 1 0 0 12617854 841 4905 NSF N-ethylmaleimide-sensitive factor 1 0 0 0 0 842 4907 NT5E 5'-nucleotidase, ecto (CD73) 1 0 0 0 0 843 59277 NTN4 netrin 4 10000 844 22854 NTNG1 netrin G1 00001 845 51667 NUB1 negative regulator of ubiquitin-like proteins 1 1 0 0 0 0 846 26471 NUPR1 nuclear protein 1 1 0 1 1 0 847 4946 OAZ1 ornithine decarboxylase antizyme 1 0 1 0 0 0 848 4947 OAZ2 ornithine decarboxylase antizyme 2 0 1 0 0 0 849 4957 ODF2 outer dense fiber of sperm tails 2 1 0 0 0 0 850 57451 ODZ2 odz, odd Oz/ten-m homolog 2 (Drosophila) 0 0 0 0 1 851 25903 OLFML2B olfactomedin-like 2B 1 0 0 0 0 852 4978 OPCML opioid binding protein/cell adhesion molecule-like 0 0 0 1 0 853 10133 OPTN optineurin 10100 854 94103 ORMDL3 ORM1-like 3 (S. cerevisiae) 1 1 0 0 0 855 5007 OSBP oxysterol binding protein 0 1 0 0 0 856 114879 OSBPL5 oxysterol binding protein-like 5 1 0 0 0 0 857 9180 OSMR oncostatin M receptor 1 0 0 0 0 858 56957 OTUD7B OTU domain containing 7B 1 0 0 0 0 859 5023 P2RX1 P2X, ligand-gated , 1 1 0 0 0 0 860 5025 P2RX4 purinergic receptor P2X, ligand-gated ion channel, 4 1 1 0 0 0 861 8974 P4HA2 procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha 10000 862 26986 PABPC1 poly(A) binding protein, cytoplasmic 1 0 1 0 0 0 863 8106 PABPN1 poly(A) binding protein, nuclear 1 0 1 1 0 0 864 5047 PAEP progestagen-associated endometrial protein (placental protein 14, pregnancy-as 00001 865 5050 PAFAH1B3 platelet-activating factor acetylhydrolase, isoform Ib, gamma subunit 29kDa 0 1 0 0 0 866 10606 PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole suc 01000 867 51247 PAIP2 poly(A) binding protein interacting protein 2 0 0 0 1 0 868 5058 PAK1 p21/Cdc42/Rac1-activated kinase 1 (STE20 homolog, yeast) 1 0 0 0 0 869 23022 PALLD palladin, cytoskeletal associated protein 1 1 1 1 0 870 54873 PALMD palmdelphin 10000 871 60676 PAPPA2 pappalysin 2 10000 872 56288 PARD3 par-3 partitioning defective 3 homolog (C. elegans) 0 0 0 0 1 873 117583 PARD3B par-3 partitioning defective 3 homolog B (C. elegans) 1 0 1 0 0 874 84612 PARD6B par-6 partitioning defective 6 homolog beta (C. elegans) 0 1 0 0 0 875 64761 PARP12 poly (ADP-ribose) polymerase family, member 12 1 0 0 0 0 876 54625 PARP14 poly (ADP-ribose) polymerase family, member 14 1 0 1 0 0 877 55742 PARVA parvin, alpha 10010 878 29780 PARVB parvin, beta 10000 879 55193 PB1 polybromo 1 00100 880 5087 PBX1 pre-B-cell leukemia homeobox 1 1 0 0 0 0 881 5089 PBX2 pre-B-cell leukemia homeobox 2 1 0 0 0 0 882 5090 PBX3 pre-B-cell leukemia homeobox 3 1 0 0 0 0 883 5093 PCBP1 poly(rC) binding protein 1 0 1 0 0 0 884 57060 PCBP4 poly(rC) binding protein 4 0 1 0 0 0 885 5097 PCDH1 protocadherin 1 1 0 0 0 0 886 51294 PCDH12 protocadherin 12 1 0 1 0 0 15541725 887 27253 PCDH17 protocadherin 17 1 0 1 0 0 888 54510 PCDH18 protocadherin 18 1 0 0 0 0 889 92211 PCDH21 protocadherin 21 1 0 0 0 0 890 56132 PCDHB3 protocadherin beta 3 1 0 0 0 0 891 56106 PCDHGA10 protocadherin gamma subfamily A, 10 0 0 0 1 0 892 10480 PCID1 PCI domain containing 1 (herpesvirus entry mediator) 0 0 1 0 0 893 5111 PCNA proliferating cell nuclear antigen 0 1 0 0 0 894 22990 PCNX pecanex homolog (Drosophila) 1 1 0 0 0 895 5118 PCOLCE procollagen C-endopeptidase enhancer 1 0 0 0 0 896 26577 PCOLCE2 procollagen C-endopeptidase enhancer 2 0 0 0 1 1 897 654790 PCP4L1 Purkinje cell protein 4 like 1 1 0 0 0 0 898 5125 PCSK5 proprotein convertase subtilisin/kexin type 5 1 0 0 0 0 899 5046 PCSK6 proprotein convertase subtilisin/kexin type 6 1 0 1 0 0 900 27250 PDCD4 programmed cell death 4 (neoplastic transformation inhibitor) 0 0 1 0 0 901 5138 PDE2A phosphodiesterase 2A, cGMP-stimulated 1 0 0 0 0 902 5139 PDE3A phosphodiesterase 3A, cGMP-inhibited 1 0 0 0 0 903 5142 PDE4B phosphodiesterase 4B, cAMP-specific (phosphodiesterase E4 dunce homolog, D 10000 904 5155 PDGFB platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) onco 1 1 0 0 0 9693135 905 5159 PDGFRB platelet-derived , beta polypeptide 1 0 0 0 0 9693135 1 906 5160 PDHA1 pyruvate dehydrogenase (lipoamide) alpha 1 0 1 0 0 0 907 10954 PDIA5 protein disulfide family A, member 5 0 0 0 0 1 908 9124 PDLIM1 PDZ and LIM domain 1 (elfin) 1 0 0 0 0 909 64236 PDLIM2 PDZ and LIM domain 2 (mystique) 1 0 1 1 0 910 10630 PDPN podoplanin 10000 911 5175 PECAM1 platelet/endothelial cell adhesion molecule (CD31 antigen) 1 0 1 0 0 10792602 1 912 57162 PELI1 pellino homolog 1 (Drosophila) 0 0 0 0 1 913 5187 PER1 period homolog 1 (Drosophila) 1 0 0 0 0 914 10404 PGCP plasma glutamate carboxypeptidase 0 0 0 1 0 915 5228 PGF , vascular endothelial growth factor-related protein 1 0 0 0 0 916 54681 PH-4 hypoxia-inducible factor prolyl 4-hydroxylase 1 0 0 0 0 917 5252 PHF1 PHD finger protein 1 1 0 0 0 0 918 5257 PHKB phosphorylase kinase, beta 0 0 1 0 0 919 23612 PHLDA3 pleckstrin homology-like domain, family A, member 3 1 0 0 0 0 920 57157 PHTF2 putative homeodomain transcription factor 2 1 0 0 0 0 921 51050 PI15 peptidase inhibitor 15 0 0 1 0 0 16498405 922 221476 PI16 peptidase inhibitor 16 1 0 0 0 0 923 5293 PIK3CD phosphoinositide-3-kinase, catalytic, delta polypeptide 1 0 0 0 0 924 5305 PIP5K2A phosphatidylinositol-4-phosphate 5-kinase, type II, alpha 1 0 0 0 0 925 8544 PIR pirin (iron-binding nuclear protein) 1 0 0 0 0 926 5306 PITPNA phosphatidylinositol transfer protein, alpha 1 0 0 0 0 927 26207 PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 1 0 0 0 0 928 57605 PITPNM2 phosphatidylinositol transfer protein, membrane-associated 2 1 0 0 0 0 929 8502 PKP4 4 00010 930 22925 PLA2R1 phospholipase A2 receptor 1, 180kDa 1 0 0 0 1 931 219348 PLAC9 placenta-specific 9 1 0 0 0 0 932 5327 PLAT plasminogen activator, tissue 1 1 1 1 1 17332733 933 5329 PLAUR plasminogen activator, 1 0 0 0 0 934 5333 PLCD1 phospholipase C, delta 1 1 0 0 0 0 935 113026 PLCD3 phospholipase C, delta 3 1 0 0 0 0 936 51196 PLCE1 phospholipase C, epsilon 1 1 0 1 0 1 937 5337 PLD1 phospholipase D1, phosphatidylcholine-specific 1 0 0 0 0 938 59339 PLEKHA2 pleckstrin homology domain containing, family A (phosphoinositide binding spec 10000 939 57480 PLEKHG1 pleckstrin homology domain containing, family G (with RhoGef domain) member 00100 940 64857 PLEKHG2 pleckstrin homology domain containing, family G (with RhoGef domain) member 10000 941 57449 PLEKHG5 pleckstrin homology domain containing, family G (with RhoGef domain) member 10000 942 130271 PLEKHH2 pleckstrin homology domain containing, family H (with MyTH4 domain) member 1 0 0 0 0 17251388 943 79990 PLEKHH3 pleckstrin homology domain containing, family H (with MyTH4 domain) member 1 0 0 0 0 944 23207 PLEKHM2 pleckstrin homology domain containing, family M (with RUN domain) member 2 0 0 1 0 0 945 51177 PLEKHO1 pleckstrin homology domain containing, family O member 1 1 0 1 0 0 946 10733 PLK4 polo-like kinase 4 (Drosophila) 1 0 0 0 0 947 5351 PLOD1 procollagen-lysine 1, 2-oxoglutarate 5-dioxygenase 1 1 0 0 0 0 948 5352 PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 1 0 0 0 0 949 84898 PLXDC2 plexin domain containing 2 1 0 0 0 0 950 5362 PLXNA2 plexin A2 10000 951 23129 PLXND1 plexin D1 10000 952 55629 PNRC2 proline-rich nuclear receptor coactivator 2 0 1 0 0 0 953 5420 PODXL podocalyxin-like 1 1 1 1 0 9188463 954 5432 POLR2C polymerase (RNA) II (DNA directed) polypeptide C, 33kDa 0 1 0 0 0 955 10631 POSTN periostin, osteoblast specific factor 0 0 0 1 1 956 8611 PPAP2A phosphatidic acid phosphatase type 2A 1 0 1 1 0 957 8613 PPAP2B phosphatidic acid phosphatase type 2B 1 1 1 1 1 958 5467 PPARD peroxisome proliferator-activated receptor delta 0 0 1 0 0 959 8495 PPFIBP2 PTPRF interacting protein, binding protein 2 (liprin beta 2) 1 0 0 0 0 960 9360 PPIG peptidylprolyl isomerase G (cyclophilin G) 0 1 0 0 0 961 9647 PPM1F protein phosphatase 1F (PP2C domain containing) 1 0 0 0 0 962 151742 PPM1L protein phosphatase 1 (formerly 2C)-like 0 1 0 0 0 963 23368 PPP1R13B protein phosphatase 1, regulatory (inhibitor) subunit 13B 1 0 0 0 0 964 5516 PPP2CB protein phosphatase 2 (formerly 2A), catalytic subunit, beta isoform 0 1 0 0 0 965 5527 PPP2R5C protein phosphatase 2, regulatory subunit B', gamma isoform 0 1 0 0 0 966 639 PRDM1 PR domain containing 1, with ZNF domain 1 0 0 0 0 967 25824 PRDX5 peroxiredoxin 5 0 1 0 0 0 968 57580 PREX1 phosphatidylinositol 3,4,5-trisphosphate-dependent RAC exchanger 1 1 0 0 0 0 969 23574 PRG1 -responsive gene 1 0 0 0 1 0 970 85441 PRIC285 peroxisomal proliferator-activated receptor A interacting complex 285 1 0 0 0 0 971 166336 PRICKLE2 prickle homolog 2 (Drosophila) 1 0 0 0 0 972 5564 PRKAB1 protein kinase, AMP-activated, beta 1 non-catalytic subunit 0 1 0 0 0 973 5571 PRKAG1 protein kinase, AMP-activated, gamma 1 non-catalytic subunit 0 1 0 0 0 974 112464 PRKCDBP protein kinase C, delta binding protein 1 0 1 0 0 975 5581 PRKCE protein kinase C, epsilon 1 0 0 0 0 976 5583 PRKCH protein kinase C, eta 1 0 0 0 0 977 5587 PRKD1 protein kinase D1 1 0 0 0 0 978 25865 PRKD2 protein kinase D2 1 0 0 0 0 979 5592 PRKG1 protein kinase, cGMP-dependent, type I 1 0 0 0 0 980 5627 PROS1 protein S (alpha) 1 0 0 0 0 981 57716 PRX periaxin 10100 1 982 5664 PSEN2 2 (Alzheimer disease 4) 1 0 0 0 0 983 5685 PSMA4 proteasome (prosome, macropain) subunit, alpha type, 4 0 1 0 0 0 984 5689 PSMB1 proteasome (prosome, macropain) subunit, beta type, 1 0 1 0 0 0 985 5706 PSMC6 proteasome (prosome, macropain) 26S subunit, ATPase, 6 0 1 0 0 0 986 5720 PSME1 proteasome (prosome, macropain) activator subunit 1 (PA28 alpha) 0 1 0 0 0 987 5725 PTBP1 polypyrimidine tract binding protein 1 0 1 0 0 0 988 5730 PTGDS prostaglandin D2 synthase 21kDa (brain) 0 0 0 1 0 989 5732 PTGER2 prostaglandin E receptor 2 (subtype EP2), 53kDa 1 0 0 0 0 990 5734 PTGER4 prostaglandin E receptor 4 (subtype EP4) 1 0 0 0 0 991 5764 PTN ( binding growth factor 8, neurite growth-promoting factor 1) 0 0 1 0 0 992 8073 PTP4A2 protein tyrosine phosphatase type IVA, member 2 0 1 0 0 0 993 11156 PTP4A3 protein tyrosine phosphatase type IVA, member 3 1 0 0 0 0 994 5782 PTPN12 protein tyrosine phosphatase, non-receptor type 12 1 1 0 0 0 995 5783 PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associa 01000 996 5787 PTPRB protein tyrosine phosphatase, receptor type, B 1 0 0 0 1 997 5793 PTPRG protein tyrosine phosphatase, receptor type, G 1 0 0 0 0 998 5797 PTPRM protein tyrosine phosphatase, receptor type, M 1 0 0 0 0 999 5800 PTPRO protein tyrosine phosphatase, receptor type, O 1 1 1 1 1 7665166 1000 284119 PTRF polymerase I and transcript release factor 0 1 1 0 0 1001 5814 PURB purine-rich element binding protein B 0 1 0 0 0 1002 5819 PVRL2 poliovirus receptor-related 2 (herpesvirus entry mediator B) 0 0 0 1 0 1003 9444 QKI quaking homolog, KH domain RNA binding (mouse) 1 0 1 0 0 1004 25797 QPCT glutaminyl-peptide cyclotransferase (glutaminyl cyclase) 1 0 0 0 0 1005 8766 RAB11A RAB11A, member RAS oncogene family 0 1 0 0 0 1006 22931 RAB18 RAB18, member RAS oncogene family 0 1 0 0 0 1007 11031 RAB31 RAB31, member RAS oncogene family 1 0 0 0 0 1008 326624 RAB37 RAB37, member RAS oncogene family 1 0 0 0 0 1009 5865 RAB3B RAB3B, member RAS oncogene family 1 0 1 0 0 1010 5866 RAB3IL1 RAB3A interacting protein (rabin3)-like 1 1 0 0 0 0 1011 51560 RAB6B RAB6B, member RAS oncogene family 1 0 0 0 0 1012 23258 RAB6IP1 RAB6 interacting protein 1 1 0 0 0 0 1013 9649 RALGPS1 Ral GEF with PH domain and SH3 binding motif 1 0 0 1 0 0 1014 10266 RAMP2 receptor (G protein-coupled) activity modifying protein 2 1 0 1 0 1 1015 10268 RAMP3 receptor (G protein-coupled) activity modifying protein 3 1 0 0 0 1 1016 5901 RAN, member RAS oncogene family 0 1 0 0 0 1017 5906 RAP1A RAP1A, member of RAS oncogene family 1 0 0 0 0 1018 5908 RAP1B RAP1B, member of RAS oncogene family 0 1 0 0 0 12196513 1019 5911 RAP2A RAP2A, member of RAS oncogene family 1 0 0 0 0 1020 10411 RAPGEF3 Rap guanine nucleotide exchange factor (GEF) 3 1 0 0 0 0 1021 11069 RAPGEF4 Rap guanine nucleotide exchange factor (GEF) 4 1 0 0 0 0 1022 9771 RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5 1 0 0 0 0 1023 65059 RAPH1 Ras association (RalGDS/AF-6) and pleckstrin homology domains 1 1 1 0 0 0 1024 5916 RARG , gamma 1 0 0 0 0 1025 22821 RASA3 RAS p21 protein activator 3 1 0 0 0 0 1026 10235 RASGRP2 RAS guanyl releasing protein 2 (calcium and DAG-regulated) 1 0 0 0 0 1027 25780 RASGRP3 RAS guanyl releasing protein 3 (calcium and DAG-regulated) 1 1 1 0 0 10835426 1028 54922 RASIP1 Ras interacting protein 1 1 1 1 0 0 1029 387496 RASL11A RAS-like, family 11, member A 1 1 1 0 0 1030 51285 RASL12 RAS-like, family 12 1 0 0 0 0 1031 5928 RBBP4 retinoblastoma binding protein 4 0 1 0 0 0 1032 84991 RBM17 RNA binding motif protein 17 0 1 0 0 0 1033 23543 RBM9 RNA binding motif protein 9 0 0 1 0 0 1034 5937 RBMS1 RNA binding motif, single stranded interacting protein 1 1 0 0 0 0 1035 5939 RBMS2 RNA binding motif, single stranded interacting protein 2 1 0 0 0 0 1036 5947 RBP1 retinol binding protein 1, cellular 0 0 0 1 0 1037 5955 RCN2 reticulocalbin 2, EF-hand calcium binding domain 0 1 0 0 0 1038 92241 RCSD1 RCSD domain containing 1 1 0 0 0 0 1039 57665 RDH14 retinol dehydrogenase 14 (all-trans/9-cis/11-cis) 0 1 0 0 0 1040 8608 RDH16 retinol dehydrogenase 16 (all-trans) 1 0 0 0 0 1041 65055 REEP1 receptor accessory protein 1 1 0 0 0 0 1042 5971 RELB v- reticuloendotheliosis viral oncogene homolog B, nuclear factor of kappa ligh 10000 1043 5972 REN renin 1 1 1 0 0 2686465 1044 85004 RERG RAS-like, estrogen-regulated, growth inhibitor 1 0 0 1 0 1045 23180 RFTN1 raftlin, lipid raft linker 1 1 0 0 0 0 1046 130132 RFTN2 raftlin family member 2 1 0 0 0 0 1047 6001 RGS10 regulator of G-protein signalling 10 0 0 0 1 0 1048 6002 RGS12 regulator of G-protein signalling 12 1 0 0 0 0 1049 5997 RGS2 regulator of G-protein signalling 2, 24kDa 1 0 1 0 0 1050 5998 RGS3 regulator of G-protein signalling 3 1 1 0 0 0 1051 5999 RGS4 regulator of G-protein signalling 4 1 0 0 0 0 1052 8490 RGS5 regulator of G-protein signalling 5 0 1 0 0 0 15337883 1053 162494 RHBDL3 rhomboid, veinlet-like 3 (Drosophila) 0 0 1 0 0 1054 388 RHOB ras homolog gene family, member B 0 0 1 0 0 1055 389 RHOC ras homolog gene family, member C 1 0 0 0 0 1056 114822 RHPN1 rhophilin, Rho GTPase binding protein 1 1 1 1 0 0 16498405 1057 9610 RIN1 Ras and Rab interactor 1 1 0 0 0 0 1058 11035 RIPK3 receptor-interacting serine-threonine kinase 3 1 0 0 0 0 1059 6016 RIT1 Ras-like without CAAX 1 1 0 0 0 0 1060 6041 RNASEL ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent) 1 0 0 0 0 1061 27289 Rho family GTPase 1 1 0 0 0 0 1062 55658 RNF126 ring finger protein 126 0 1 0 0 0 1063 9781 RNF144 ring finger protein 144 1 0 0 0 0 1064 64320 RNF25 ring finger protein 25 0 1 0 0 0 1065 9616 RNF7 ring finger protein 7 0 0 0 1 0 1066 6092 ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) 0 0 1 0 0 1067 54538 ROBO4 roundabout homolog 4, magic roundabout (Drosophila) 1 0 1 0 0 1068 9475 ROCK2 Rho-associated, coiled-coil containing protein kinase 2 1 1 0 0 0 1069 6134 RPL10 ribosomal protein L10 0 1 0 0 0 1070 9045 RPL14 ribosomal protein L14 0 1 0 0 0 1071 6138 RPL15 ribosomal protein L15 0 1 0 0 0 1072 6175 RPLP0 ribosomal protein, large, P0 0 1 0 0 0 1073 6208 RPS14 ribosomal protein S14 0 0 0 1 0 1074 6187 RPS2 ribosomal protein S2 0 1 0 0 0 1075 6188 RPS3 ribosomal protein S3 0 1 0 0 0 1076 140032 RPS4Y2 ribosomal protein S4, Y-linked 2 0 1 0 0 0 1077 6196 RPS6KA2 kinase, 90kDa, polypeptide 2 1 0 0 0 0 1078 6197 RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 0 1 0 0 0 1079 3921 RPSA ribosomal protein SA 0 1 0 0 0 11553521 1080 6236 RRAD Ras-related associated with diabetes 1 0 0 0 0 1081 6237 RRAS related RAS viral (r-ras) oncogene homolog 1 0 1 0 0 1082 84870 RSPO3 R-spondin 3 homolog (Xenopus laevis) 1 0 0 0 0 1083 6253 RTN2 reticulon 2 10000 1084 57142 RTN4 reticulon 4 00100 1085 146760 RTN4RL1 reticulon 4 receptor-like 1 1 0 0 0 0 1086 64108 RTP4 receptor (chemosensory) transporter protein 4 0 0 1 0 0 1087 9853 RUSC2 RUN and SH3 domain containing 2 1 0 0 0 0 1088 6284 S100A13 S100 calcium binding protein A13 1 0 0 0 0 1089 6275 S100A4 S100 calcium binding protein A4 1 0 0 0 0 1090 6277 S100A6 S100 calcium binding protein A6 1 0 0 0 0 1 1091 6279 S100A8 S100 calcium binding protein A8 0 0 0 0 1 1092 25939 SAMHD1 SAM domain and HD domain 1 1 0 0 0 0 1093 29115 SAP30BP SAP30 binding protein 1 0 0 0 0 1094 8578 SCARF1 scavenger receptor class F, member 1 1 0 0 0 0 1095 91179 SCARF2 scavenger receptor class F, member 2 1 0 1 0 0 1096 29970 SCHIP1 schwannomin interacting protein 1 1 0 1 0 0 1097 6332 SCN7A , voltage-gated, type VII, alpha 1 0 0 0 0 1098 57147 SCYL3 SCY1-like 3 (S. cerevisiae) 0 0 1 0 0 1099 6382 SDC1 syndecan 1 10000 1100 9672 SDC3 syndecan 3 10000 1101 8436 SDPR serum deprivation response (phosphatidylserine binding protein) 1 1 0 0 0 1102 6397 SEC14L1 SEC14-like 1 (S. cerevisiae) 1 0 0 0 0 1103 6401 SELE E (endothelial adhesion molecule 1) 1 0 0 0 0 1104 9723 SEMA3E sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (sema 10000 1105 6405 SEMA3F sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (sema 1 1 0 0 0 12617854 1106 56920 SEMA3G sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (sema 0 1 1 0 0 16498405 1107 9037 SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmem 00100 1108 80031 SEMA6D sema domain, transmembrane domain (TM), and cytoplasmic domain, (semapho 10000 1109 6414 SEPP1 selenoprotein P, plasma, 1 0 1 0 0 0 9377220 1110 55752 SEPT11 septin 11 10000 1111 5413 SEPT5 septin 5 10000 1112 23157 SEPT6 septin 6 10000 1113 10169 SERF2 small EDRK-rich factor 2 0 1 0 0 0 1114 10955 SERINC3 serine incorporator 3 1 1 0 0 0 1115 5054 SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1) 10000 1116 5270 SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1) 1 0 1 0 0 8943477 1117 5274 SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1 1 0 1 0 0 1118 29950 SERTAD1 SERTA domain containing 1 1 0 1 0 0 1119 29946 SERTAD3 SERTA domain containing 3 1 0 0 0 0 1120 26470 SEZ6L2 seizure related 6 homolog (mouse)-like 2 1 0 0 0 0 1121 6423 SFRP2 secreted frizzled-related protein 2 1 1 1 0 0 16498405 1122 6428 SFRS3 splicing factor, /serine-rich 3 0 1 0 0 0 1123 6432 SFRS7 splicing factor, arginine/serine-rich 7, 35kDa 0 0 0 1 0 1124 6433 SFRS8 splicing factor, arginine/serine-rich 8 (suppressor-of-white-apricot homolog, Dros 01000 1125 8910 SGCE sarcoglycan, epsilon 0 0 0 1 0 1126 26084 SGEF Src homology 3 domain-containing guanine nucleotide exchange factor 1 0 0 0 0 1127 84251 SGIP1 SH3-domain GRB2-like (endophilin) interacting protein 1 1 0 0 0 0 1128 6446 SGK serum/glucocorticoid regulated kinase 1 1 1 0 0 12435876 1129 10603 SH2B2 SH2B adaptor protein 2 1 0 0 0 0 1130 10019 SH2B3 SH2B adaptor protein 3 1 0 1 0 0 1131 10044 SH2D3C SH2 domain containing 3C 1 0 1 0 0 1132 63898 SH2D4A SH2 domain containing 4A 1 0 0 0 0 17251388 1133 83699 SH3BGRL2 SH3 domain binding glutamic acid-rich protein like 2 1 0 0 0 0 1134 23677 SH3BP4 SH3-domain binding protein 4 0 1 0 0 0 1135 51100 SH3GLB1 SH3-domain GRB2-like endophilin B1 1 1 0 0 0 1 1136 257364 SH3PX3 SH3 and PX domain containing 3 1 0 0 0 0 1137 285590 SH3PXD2B SH3 and PX domains 2B 1 0 0 0 0 1138 85358 SHANK3 SH3 and multiple ankyrin repeat domains 3 1 0 0 1 0 1 1139 126669 SHE Src homology 2 domain containing E 0 1 0 0 0 1140 57619 SHROOM3 shroom family member 3 1 0 0 0 0 1141 22827 SIAHBP1 fuse-binding protein-interacting repressor 0 1 0 0 0 1142 6494 SIPA1 signal-induced proliferation-associated gene 1 1 0 0 0 0 1143 57568 SIPA1L2 signal-induced proliferation-associated 1 like 2 1 0 1 0 0 1144 10572 SIVA1 SIVA1, -inducing factor 1 0 1 0 0 1145 6497 SKI v-ski sarcoma viral oncogene homolog (avian) 0 1 0 0 0 1146 51763 SKIP skeletal muscle and kidney enriched inositol phosphatase 1 0 0 0 0 1147 6503 SLA Src-like-adaptor 1 0 0 0 0 1148 6560 SLC12A4 solute carrier family 12 (potassium/chloride transporters), member 4 1 0 0 0 0 1149 9962 SLC23A2 solute carrier family 23 (nucleobase transporters), member 2 1 0 0 0 0 1150 292 SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), m 01000 1151 11000 SLC27A3 solute carrier family 27 (fatty acid transporter), member 3 1 0 0 0 0 1152 2030 SLC29A1 solute carrier family 29 (nucleoside transporters), member 1 1 0 0 0 0 1153 81031 SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10 1 0 0 0 0 1154 154091 SLC2A12 solute carrier family 2 (facilitated glucose transporter), member 12 0 1 0 0 0 1155 1318 SLC31A2 solute carrier family 31 (copper transporters), member 2 1 0 0 0 0 1156 29015 SLC43A3 solute carrier family 43, member 3 1 0 0 0 0 1157 57153 SLC44A2 solute carrier family 44, member 2 1 0 0 0 0 1158 6533 SLC6A6 solute carrier family 6 (neurotransmitter transporter, taurine), member 6 1 0 1 0 0 1159 9351 SLC9A3R2 solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2 1 0 1 1 0 11121391 1 1160 6578 SLCO2A1 solute carrier organic anion transporter family, member 2A1 1 0 1 0 0 1161 162394 SLFN5 schlafen family member 5 0 1 0 0 0 1162 9748 SLK STE20-like kinase (yeast) 0 1 0 0 0 1163 4091 SMAD6 SMAD family member 6 1 0 0 0 1 11170839 1164 64744 SMAP1L stromal membrane-associated protein 1-like 0 1 0 0 0 1165 6595 SMARCA2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, sub 00100 1166 6597 SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, sub 00100 1167 23049 SMG1 PI-3-kinase-related kinase SMG-1 0 1 0 0 0 1168 57154 SMURF1 SMAD specific E3 ubiquitin protein 1 1 0 0 0 0 1169 6615 SNAI1 snail homolog 1 (Drosophila) 1 0 0 0 0 1170 9627 SNCAIP synuclein, alpha interacting protein (synphilin) 1 0 1 0 0 1171 54861 SNRK SNF related kinase 1 0 0 0 0 1172 6645 SNTB2 syntrophin, beta 2 (dystrophin-associated protein A1, 59kDa, basic component 2 00100 1173 51429 SNX9 9 0 1 0 0 0 1174 9021 SOCS3 suppressor of cytokine signaling 3 1 0 0 1 0 1175 9655 SOCS5 suppressor of cytokine signaling 5 1 0 0 0 0 1176 10174 SORBS3 sorbin and SH3 domain containing 3 1 0 0 0 0 1177 50964 SOST sclerosteosis 00010 1178 9580 SOX13 SRY (sex determining region Y)-box 13 1 0 1 0 0 1179 64321 SOX17 SRY (sex determining region Y)-box 17 1 0 1 0 0 1180 54345 SOX18 SRY (sex determining region Y)-box 18 1 0 0 0 0 1181 83595 SOX7 SRY (sex determining region Y)-box 7 1 0 0 0 0 1182 6670 SP3 0 1 0 0 0 1 1183 6678 SPARC secreted protein, acidic, cysteine-rich (osteonectin) 1 0 1 1 1 1279269 1 1184 6695 SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 0 0 0 1 1 1185 9806 SPOCK2 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2 1 0 0 1 1 1186 6696 SPP1 secreted phosphoprotein 1 (osteopontin, bone sialoprotein I, early T-lymphocyte 0 1 0 0 0 14758529 1187 84888 SPPL2A peptidase-like 2A 0 1 0 0 0 1188 161742 SPRED1 sprouty-related, EVH1 domain containing 1 1 0 0 0 0 1189 81848 SPRY4 sprouty homolog 4 (Drosophila) 1 0 0 0 0 1190 57522 SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0 0 1 0 0 1191 23380 SRGAP2 SLIT-ROBO Rho GTPase activating protein 2 1 0 0 0 1 1192 5552 SRGN serglycin 10100 1193 10250 SRRM1 serine/arginine repetitive matrix 1 0 1 0 0 0 1194 6744 SSFA2 sperm specific antigen 2 1 1 0 0 0 1195 8082 SSPN sarcospan (Kras oncogene-associated gene) 1 0 0 0 0 1196 6746 SSR2 signal sequence receptor, beta (translocon-associated protein beta) 0 1 0 0 0 1197 6767 ST13 suppression of tumorigenicity 13 (colon carcinoma) ( interacting protein) 0 1 0 0 0 1198 6482 ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 1 0 0 0 0 1199 6484 ST3GAL4 ST3 beta-galactoside alpha-2,3-sialyltransferase 4 1 0 0 0 0 1200 8869 ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 1 0 0 0 0 1201 10402 ST3GAL6 ST3 beta-galactoside alpha-2,3-sialyltransferase 6 1 0 0 0 0 1202 256435 ST6GALNAC3 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminid 10000 1203 27090 ST6GALNAC4 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminid 10000 1204 30815 ST6GALNAC6 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminid 10100 1205 7903 ST8SIA4 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 1 0 0 0 0 1206 55576 STAB2 stabilin 2 10000 1207 55620 STAP2 signal-transducing adaptor protein-2 1 0 0 0 0 1208 6772 STAT1 signal transducer and activator of transcription 1, 91kDa 1 0 0 0 0 1209 6777 STAT5B signal transducer and activator of transcription 5B 0 0 0 0 1 1210 6778 STAT6 signal transducer and activator of transcription 6, interleukin-4 induced 1 0 0 0 0 1211 55240 STEAP3 STEAP family member 3 1 0 0 0 0 1212 6793 STK10 serine/threonine kinase 10 1 0 1 0 0 1213 11075 STMN2 -like 2 1 0 0 0 0 1214 8676 STX11 11 00010 1215 6812 STXBP1 syntaxin binding protein 1 1 0 0 0 0 1216 6815 STYX serine/threonine/tyrosine interacting protein 0 1 0 0 0 1217 23213 SULF1 sulfatase 1 10001 1218 6612 SUMO3 SMT3 suppressor of mif two 3 homolog 3 (S. cerevisiae) 0 1 0 0 0 1219 6836 SURF4 surfeit 4 01000 1220 85360 SYDE1 synapse defective 1, Rho GTPase, homolog 1 (C. elegans) 1 0 0 0 0 1221 25949 SYF2 SYF2 homolog, RNA splicing factor (S. cerevisiae) 0 1 1 0 0 1222 23345 SYNE1 repeat containing, 1 0 0 0 0 1 1223 8871 SYNJ2 synaptojanin 2 1 0 0 0 0 1224 11346 SYNPO synaptopodin 0 1 1 1 0 1856454 1225 23208 SYT11 XI 1 0 0 0 0 1226 6867 TACC1 transforming, acidic coiled-coil containing protein 1 1 1 0 0 0 1227 51616 TAF9B TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 3 10000 1228 6886 TAL1 T-cell acute lymphocytic leukemia 1 1 0 0 0 0 1229 23102 TBC1D2B TBC1 domain family, member 2B 1 0 0 0 0 1230 9755 TBKBP1 TBK1 binding protein 1 0 0 1 0 0 1231 6926 TBX3 T-box 3 (ulnar mammary syndrome) 1 0 1 0 0 1232 6915 TBXA2R thromboxane A2 receptor 1 0 0 0 0 1233 6924 TCEB3 transcription elongation factor B (SIII), polypeptide 3 (110kDa, elongin A) 0 1 0 0 0 1234 6943 TCF21 transcription factor 21 1 1 1 1 0 12619136 1235 22980 TCF25 transcription factor 25 (basic helix-loop-helix) 0 1 0 0 0 1236 83439 TCF7L1 transcription factor 7-like 1 (T-cell specific, HMG-box) 1 0 0 0 0 1237 7010 TEK TEK tyrosine kinase, endothelial (venous malformations, multiple cutaneous and 1 1 0 0 1 11261688 1238 23371 TENC1 tensin like C1 domain containing phosphatase (tensin 2) 1 0 1 1 0 1239 7014 TERF2 telomeric repeat binding factor 2 0 0 1 0 0 1240 7035 TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 1 0 0 0 0 1241 7040 TGFB1 transforming growth factor, beta 1 (Camurati-Engelmann disease) 1 0 0 0 0 8441250 1242 7041 TGFB1I1 transforming growth factor beta 1 induced transcript 1 1 0 0 0 0 1243 7048 TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 1 0 0 1 1 1244 7049 TGFBR3 transforming growth factor, beta receptor III 1 0 0 1 0 1245 7056 THBD 1 0 0 0 0 1246 10025 THRAP5 associated protein 5 0 0 1 0 0 1247 55901 THSD1 thrombospondin, type I, domain containing 1 1 0 0 0 0 1248 221981 THSD7A thrombospondin, type I, domain containing 7A 0 1 1 0 0 1 1249 7072 TIA1 TIA1 cytotoxic granule-associated RNA binding protein 0 1 0 0 0 1250 7073 TIAL1 TIA1 cytotoxic granule-associated RNA binding protein-like 1 0 0 1 0 0 1251 7075 TIE1 tyrosine kinase with immunoglobulin-like and EGF-like domains 1 1 1 0 0 0 9642132 1252 92610 TIFA TRAF-interacting protein with a forkhead-associated domain 1 0 0 0 0 1253 8914 TIMELESS timeless homolog (Drosophila) 1 0 0 0 0 1254 7076 TIMP1 TIMP metallopeptidase inhibitor 1 1 0 0 1 0 1255 7077 TIMP2 TIMP metallopeptidase inhibitor 2 1 0 0 1 0 1256 7078 TIMP3 TIMP metallopeptidase inhibitor 3 (Sorsby fundus dystrophy, pseudoinflammator 10110 1257 64129 TINAGL1 tubulointerstitial nephritis antigen-like 1 1 0 0 0 0 1258 7082 TJP1 (zona occludens 1) 1 1 1 0 0 2202736 1 1259 7091 TLE4 transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila) 1 0 0 0 0 1260 7095 TLOC1 translocation protein 1 0 1 0 0 0 1261 7099 TLR4 toll-like receptor 4 1 0 0 0 0 1262 4071 TM4SF1 transmembrane 4 L six family member 1 1 1 1 1 0 17332733 1263 64114 TMBIM1 transmembrane BAX inhibitor motif containing 1 1 0 0 0 0 1264 79905 TMC7 transmembrane channel-like 7 1 0 0 0 0 1265 9911 TMCC2 transmembrane and coiled-coil domain family 2 1 0 0 0 0 1266 57458 TMCC3 transmembrane and coiled-coil domain family 3 1 0 0 0 0 1267 23671 TMEFF2 transmembrane protein with EGF-like and two follistatin-like domains 2 1 0 0 0 0 1268 79073 TMEM109 transmembrane protein 109 1 0 1 0 0 1269 84876 TMEM142A transmembrane protein 142A 1 0 0 0 0 1270 57583 TMEM181 transmembrane protein 181 1 0 0 0 0 1271 130827 TMEM182 transmembrane protein 182 1 0 0 0 0 1272 23670 TMEM2 transmembrane protein 2 1 0 0 0 0 1273 83604 TMEM47 transmembrane protein 47 1 0 0 0 0 1274 23585 TMEM50A transmembrane protein 50A 0 1 0 0 0 1275 113452 TMEM54 transmembrane protein 54 1 0 0 0 0 1276 137835 TMEM71 transmembrane protein 71 1 0 0 0 0 1277 92162 TMEM88 transmembrane protein 88 1 0 0 0 0 1278 26022 TMEM98 transmembrane protein 98 1 0 0 0 0 1279 56937 TMEPAI transmembrane, prostate androgen induced RNA 1 0 0 0 1 1280 29766 TMOD3 3 (ubiquitous) 1 1 1 0 0 1281 7112 TMPO thymopoietin 01000 1282 9168 TMSB10 thymosin, beta 10 0 0 0 1 0 1283 7114 TMSB4X thymosin, beta 4, X-linked 0 0 0 1 0 1284 9087 TMSB4Y thymosin, beta 4, Y-linked 0 0 0 1 0 1285 83857 TMTC1 transmembrane and tetratricopeptide repeat containing 1 1 0 0 0 0 1286 160335 TMTC2 transmembrane and tetratricopeptide repeat containing 2 1 0 0 0 0 1287 3371 TNC tenascin C (hexabrachion) 0 0 0 1 0 1288 7126 TNFAIP1 tumor necrosis factor, alpha-induced protein 1 (endothelial) 1 0 0 0 0 1289 7127 TNFAIP2 tumor necrosis factor, alpha-induced protein 2 1 0 0 1 0 1290 126282 TNFAIP8L1 tumor necrosis factor, alpha-induced protein 8-like 1 1 0 0 0 0 1291 4982 TNFRSF11B tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin) 1 0 0 0 0 1292 8743 TNFSF10 tumor necrosis factor (ligand) superfamily, member 10 1 0 0 0 0 1293 8741 TNFSF13 tumor necrosis factor (ligand) superfamily, member 13 1 0 0 0 0 1294 85456 TNKS1BP1 1 binding protein 1, 182kDa 1 0 0 0 0 1295 7135 TNNI1 type 1 (skeletal, slow) 0 0 0 1 0 1296 7139 TNNT2 type 2 (cardiac) 0 0 0 1 1 1297 64759 TNS3 tensin 3 10000 1298 10140 TOB1 transducer of ERBB2, 1 0 1 0 0 0 1299 54543 TOMM7 of outer mitochondrial membrane 7 homolog (yeast) 0 0 0 1 0 1300 7150 TOP1 topoisomerase (DNA) I 0 0 1 0 0 1301 116447 TOP1MT topoisomerase (DNA) I, mitochondrial 1 0 1 0 0 1302 26092 TOR1AIP1 torsin A interacting protein 1 0 1 0 0 0 1303 7165 TPD52L2 tumor protein D52-like 2 0 1 0 0 0 1304 7169 TPM2 2 (beta) 0 0 0 1 0 1305 11076 TPPP brain-specific protein p25 alpha 1 0 0 0 0 1306 133022 TRAM1L1 translocation associated membrane protein 1-like 1 1 0 0 0 0 1307 6399 TRAPPC2 trafficking protein particle complex 2 0 1 0 0 0 1308 28951 TRIB2 tribbles homolog 2 (Drosophila) 0 0 1 0 0 1309 51592 TRIM33 tripartite motif-containing 33 0 1 0 0 0 1310 55223 TRIM62 tripartite motif-containing 62 1 0 0 0 0 1311 7216 TRO trophinin 10000 1312 7220 TRPC1 transient receptor potential cation channel, subfamily C, member 1 1 0 0 0 0 1313 7223 TRPC4 transient receptor potential cation channel, subfamily C, member 4 1 0 0 0 0 1314 7225 TRPC6 transient receptor potential cation channel, subfamily C, member 6 1 0 0 0 0 1315 8848 TSC22D1 TSC22 domain family, member 1 0 1 0 0 0 1316 95681 TSGA14 testis specific, 14 1 0 0 0 0 1317 128553 TSHZ2 teashirt family zinc finger 2 1 0 0 0 0 1318 85480 TSLP thymic stromal lymphopoietin 1 0 0 0 0 1319 23555 TSPAN15 15 1 0 1 0 0 1320 26262 TSPAN17 tetraspanin 17 1 0 0 0 0 1321 10100 TSPAN2 tetraspanin 2 10100 1322 7106 TSPAN4 tetraspanin 4 10000 1323 10098 TSPAN5 tetraspanin 5 10000 1324 90121 TSR2 TSR2, 20S rRNA accumulation, homolog (S. cerevisiae) 1 0 0 0 0 1325 23548 TTC33 tetratricopeptide repeat domain 33 0 1 0 0 0 1326 9694 TTC35 tetratricopeptide repeat domain 35 0 1 0 0 0 1327 11344 TWF2 twinfilin, actin-binding protein, homolog 2 (Drosophila) 1 0 0 0 0 1328 7291 TWIST1 twist homolog 1 (acrocephalosyndactyly 3; Saethre-Chotzen syndrome) (Drosop 10000 1329 10628 TXNIP thioredoxin interacting protein 0 1 0 0 0 14531794 1330 9352 TXNL1 thioredoxin-like 1 0 1 0 0 0 1331 7301 TYRO3 TYRO3 protein tyrosine kinase 1 0 0 0 1 1332 55075 UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 1 1 1 0 0 1333 10422 UBADC1 ubiquitin associated domain containing 1 0 1 0 0 0 1334 7316 UBC 01100 1335 7318 UBE1L ubiquitin-activating enzyme E1-like 1 0 0 1 0 1336 7322 UBE2D2 ubiquitin-conjugating enzyme E2D 2 (UBC4/5 homolog, yeast) 0 1 0 0 0 1337 7328 UBE2H ubiquitin-conjugating enzyme E2H (UBC8 homolog, yeast) 0 1 0 0 0 1338 65264 UBE2Z ubiquitin-conjugating enzyme E2Z (putative) 0 1 0 0 0 1339 7343 UBTF upstream binding transcription factor, RNA polymerase I 0 1 0 0 0 1 1340 7345 UCHL1 ubiquitin carboxyl-terminal esterase (ubiquitin thiolesterase) 1 0 0 0 0 1341 7371 UCK2 uridine-cytidine kinase 2 1 0 0 0 0 1342 51506 UFC1 ubiquitin-fold modifier conjugating enzyme 1 0 1 0 0 0 1343 7357 UGCG UDP-glucose ceramide glucosyltransferase 1 0 0 0 0 1344 8408 ULK1 unc-51-like kinase 1 (C. elegans) 1 0 0 0 0 1345 10497 UNC13B unc-13 homolog B (C. elegans) 0 1 0 0 0 9607201 1346 146862 UNC45B unc-45 homolog B (C. elegans) 0 0 1 0 0 1347 219699 UNC5B unc-5 homolog B (C. elegans) 1 0 1 0 0 1348 8633 UNC5C unc-5 homolog C (C. elegans) 1 0 0 0 0 1349 7378 UPP1 uridine phosphorylase 1 1 0 0 0 0 1350 7386 UQCRFS1 ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1 0 1 0 0 0 1351 83878 USHBP1 1C binding protein 1 1 0 0 0 0 1352 11274 USP18 ubiquitin specific peptidase 18 1 0 0 0 0 1353 55230 USP40 ubiquitin specific peptidase 40 0 0 1 0 0 1354 7403 UTX ubiquitously transcribed tetratricopeptide repeat, 0 0 1 0 0 1355 6844 VAMP2 vesicle-associated membrane protein 2 ( 2) 1 0 0 0 0 1356 10791 VAMP5 vesicle-associated membrane protein 5 (myobrevin) 1 0 0 1 0 1357 81839 VANGL1 vang-like 1 (van gogh, Drosophila) 1 0 0 0 0 1358 9217 VAPB VAMP (vesicle-associated membrane protein)-associated protein B and C 1 0 0 0 0 1359 114990 VASN vasorin 11100 1360 10493 VAT1 vesicle amine transport protein 1 homolog (T. californica) 1 0 0 0 0 1361 7412 VCAM1 vascular cell adhesion molecule 1 0 0 0 1 0 1362 7414 VCL 1 1 0 0 0 9422981 1363 7415 VCP valosin-containing protein 0 0 0 1 0 1364 7422 VEGFA vascular endothelial growth factor A 1 1 0 1 0 1592003 1365 7716 VEZF1 vascular endothelial zinc finger 1 1 0 0 0 0 1366 389136 VGLL3 vestigial like 3 (Drosophila) 1 0 0 0 0 1367 9686 VGLL4 vestigial like 4 (Drosophila) 0 0 1 0 0 1368 7430 VIL2 villin 2 (ezrin) 0 1 0 0 0 9853258 1369 7431 VIM vimentin 1 1 1 1 0 6201675 1 1370 7432 VIP vasoactive intestinal peptide 1 0 0 0 0 1371 154807 VKORC1L1 vitamin K epoxide reductase complex, subunit 1-like 1 0 1 0 0 0 1372 84313 VPS25 25 homolog (S. cerevisiae) 0 1 0 0 0 1373 7453 WARS tryptophanyl-tRNA synthetase 1 0 0 0 0 1374 23558 WBP2 WW domain binding protein 2 0 0 1 0 0 1375 51186 WBP5 WW domain binding protein 5 0 1 0 0 0 1376 348793 WDR53 WD repeat domain 53 1 0 0 0 0 1377 58189 WFDC1 WAP four-disulfide core domain 1 1 0 0 0 0 1378 11197 WIF1 WNT inhibitory factor 1 1 0 1 0 0 1379 65125 WNK1 WNK lysine deficient protein kinase 1 0 1 0 0 0 1380 81029 WNT5B wingless-type MMTV integration site family, member 5B 1 0 0 0 0 1381 55884 WSB2 WD repeat and SOCS box-containing 2 1 0 0 0 0 1382 7490 WT1 Wilms tumor 1 1 0 1 1 0 8382938 1 1383 84272 YIPF4 Yip1 domain family, member 4 0 1 0 0 0 1384 83719 YPEL3 yippee-like 3 (Drosophila) 0 0 1 0 0 1385 7534 YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zet 0 1 0 0 0 1386 58486 ZBED5 zinc finger, BED-type containing 5 0 1 0 0 0 1387 26137 ZBTB20 zinc finger and BTB domain containing 20 0 0 0 0 1 1388 201501 ZBTB7C zinc finger and BTB domain containing 7C 1 0 0 0 0 1389 653121 ZBTB8 zinc finger and BTB domain containing 8 1 0 0 0 0 1390 80149 ZC3H12A zinc finger CCCH-type containing 12A 1 0 0 0 0 1391 79683 ZDHHC14 zinc finger, DHHC-type containing 14 1 0 1 0 0 1392 64429 ZDHHC6 zinc finger, DHHC-type containing 6 0 0 0 1 1 1393 6935 ZEB1 zinc finger E-box binding homeobox 1 1 0 1 0 1 1394 90637 ZFAND2A zinc finger, AN1-type domain 2A 1 0 0 0 0 1395 60685 ZFAND3 zinc finger, AN1-type domain 3 0 1 0 0 0 1396 677 ZFP36L1 zinc finger protein 36, C3H type-like 1 0 1 0 0 0 1397 118813 ZFYVE27 zinc finger, FYVE domain containing 27 1 0 0 0 0 1398 22882 ZHX2 zinc fingers and 2 0 1 0 0 0 1399 7739 ZNF185 zinc finger protein 185 (LIM domain) 1 0 0 0 0 1400 55905 ZNF313 zinc finger protein 313 0 1 0 0 0 1401 7580 ZNF32 zinc finger protein 32 0 1 0 0 0 1402 23090 ZNF423 zinc finger protein 423 1 0 0 0 0 1403 151126 ZNF533 zinc finger protein 533 1 0 0 0 0 1404 57507 ZNF608 zinc finger protein 608 0 0 1 0 0 1405 84937 ZNRF1 zinc and ring finger 1 1 0 0 0 0 1406 57643 ZSWIM5 zinc finger, SWIM-type containing 5 0 0 1 0 0 1407 7791 ZYX zyxin 01000 ACHE COL4A1 ACTG1 ANXA5 ACTG1 GSN ACTG1 TMSB4X ACTG1 TMSB4Y ACTG1 PTPRO ACTG1 CFL1 ACTG1 PLD1 ACTG1 FHOD1 ACTG1 CAP2 ACTA1 GSN ACTA1 PRKCE ACTA1 TNNI1 ACTA1 VCL ACTA1 TMSB4X ACTA1 MYLK ACTA1 TJP1 ACTA1 CFL1 ACTA1 MYO10 ACTA1 AIF1 ACTA1 PLD1 ACTA1 PAK1 ACTA1 CORO2B ACTA1 FHOD1 ACTA1 CLIC5 ACTA1 CCT5 ACTA1 S100A4 ACTA1 PARVA ACTB ACTG1 ACTB VIL2 ACTB NT5E ACTB EEF1A1 ACTB GSN ACTB LMNA ACTB PTN ACTB LYN ACTB TMSB4X ACTB CFL1 ACTB MYO1E ACTB PLD1 ACTB HNRPAB ACTB SMARCA4 ACTB CPNE2 ACTB CCT5 ACTB ARPC1B ACTB TPM2 AK1 FHL2 ADCY1 GNAI2 ARF1 CHRM3 ARF1 PLD1 ARF1 COPE ADM MME ADM CALCRL A2M B2M A2M CTSB A2M PAEP A2M KLK3 A2M PDGFB A2M ADAM19 A2M NGFB APLP1 TMSB4X APLP1 TCF21 APLP1 TSC22D1 ANXA3 EMG1 CD38 PECAM1 ARRB1 FLNA ARRB1 NSF NPR1 PRKG1 AXL IL2RG AXL NCK2 AXL TENC1 CD40 MAP3K8 CD40 JAK3 B2M HLA-E B2M CD1D CEACAM1 FLNA BMP2 ENG BMP2 MGP BMP2 TGFB1 BMP2 BMPER CDH2 CTNNB1 CDH2 CREBBP CDH2 BOC CALCA RAMP2 CALCA CALCRL CALM1 CSNK2A1 CALM1 CLTB CALM1 HSP90AA1 CALM1 ITPKB CALM1 RRAD CALM1 RAB3B CALM1 RGS2 CALM1 MYLK CALM1 MYO10 CALM1 NRGN CALM1 RGS4 CALM1 RGS10 CALM1 PLCD1 CALM2 RAB3B CALM3 RAB3B CALM3 AKAP9 CPM EGF CSNK2A1 CTNNB1 CSNK2A1 TOP1 CSNK2A1 EGR1 CSNK2A1 FGF1 CSNK2A1 HSP90AA1 CSNK2A1 IFI16 CSNK2A1 FOS CSNK2A1 MYCN CSNK2A1 JUN CSNK2A1 SPP1 CSNK2A1 RRAD CSNK2A1 MEF2C CSNK2A1 UBTF CSNK2A1 PSEN2 CSNK2A1 PAK1 CSNK2A1 RNF7 CSNK2A1 HSPB8 CSNK2A1 PSMA4 CSNK2A1 PLEKHO1 CTNNB1 VIL2 CTNNB1 FYN CTNNB1 FLT1 CTNNB1 PECAM1 CTNNB1 PTPRM CTNNB1 TGFBR2 CTNNB1 KDR CTNNB1 PTPN13 CTNNB1 PSEN2 CTNNB1 FHL2 CTNNB1 SMARCA4 CTNNB1 DLG5 CTNNB1 TCF7L1 CTNNB1 BOC CTNNB1 MAGI2 CTNNB1 SOX17 CTSB REN CTSB RGS2 CEBPD CREBBP CDKN1A CSNK2A1 CDKN1A GADD45A CDKN1A PCNA CDKN1A GADD45B CDKN1A GADD45G CDKN1A CCDC85B CDKN1A IBRDC2 CDC25B CSNK2A1 CDC25B CREBBP CDC25B YWHAZ CHRM3 GNAQ CLTB CSNK2A1 CLTB HIP1 SSFA2 LUC7L2 COL4A3 CD93 COL4A3 DCN COL4A3 SERPINE2 COL4A1 CD93 COL4A1 DCN COL4A1 NID1 COL4A1 SERPINE2 COL4A4 CD93 COL4A4 DCN COL4A4 SERPINE2 COL13A1 NID1 COL13A1 SPARC COL13A1 NID2 MME VIP CTGF TGFB1 CTGF VEGFA GJA1 GJA3 GJA1 PRKCE GJA1 TJP1 GJA1 GJA5 GJA3 TJP1 VIL2 SLC9A3R2 VIL2 CLIC5 VIL2 SCYL3 VIL2 PALLD CD55 FYN DCN TGFB1 DCN FLNA GADD45A PCNA EGR1 JUN EGR1 NAB1 EGR1 NAB2 EEF1A1 PAEP EEF1A1 PLAUR EEF1A1 WARS EEF1A1 PAFAH1B3 EEF1A1 EIF3S5 EEF1A1 GADD45G EEF1A1 KIF1B EEF1A1 C11orf79 EEF1A1 STMN2 EEF1A1 POLR2C EEF1A1 ORMDL3 ENG TGFB1 ENG TGFBR2 ENG TGFBR3 SELE VCL FGF1 S100A13 FGF1 NRP1 FGF1 RPS2 FGF1 FGFBP1 ANXA5 ITGB5 ANXA5 KDR EDNRA GNAI2 GATA3 LMO2 GATA3 LMO1 GATA3 TAL1 EGF LMNA EGF ADAM12 EPOR LYN EPOR KITLG EPOR SOCS3 EPOR STAT5B EPOR GRAP EPOR GAB2 EPOR INPP5D EPOR SH2B2 F3 FLNA FNTA TGFB1 FNTA PTP4A3 FAS CALM1 FAS VIL2 FAS EEF1A1 FAS FYN FAS RAP1A FAS UBE1L FAS PTPN13 FAS CD47 FAS TNFSF13 FTH1 GOLPH2 ITGA5 ITGB1 ITGA5 ITGB5 ITGA5 SPP1 ITGA5 PECAM1 ITGB1 LGALS1 ITGB1 SPP1 ITGB1 PRKCE ITGB1 VCAM1 ITGB1 TSPAN4 ITGB1 MAP4K4 ITGB1 ITGB1BP1 ITGB1 ITGA8 FLT4 ITGA5 FLT4 ITGB1 FLT4 KDR FYN MCAM FYN PLAUR FYN PDGFRB FYN PECAM1 FYN PRKCE FYN SDC3 FYN KDR FYN TEK FYN TYRO3 FYN STAT1 FYN LCP2 FYN K-ALPHA-1 FYN NPHS1 FYN TRPC6 FYN GRAP FYN PRKCH FYN ADAM15 FYN SH2B2 FYN DOK4 GSN VCL GSN CLIC5 GNAI2 RGS12 GNAI2 RGS4 GNAI2 RGS5 GUCY1B3 HSP90AA1 HSP90AA1 NOS3 HSP90AA1 KDR HSP90AA1 NR2C2 HSP90AA1 MAP3K3 HSP90AA1 ST13 HLA-DRA HLA-DRB1 ICAM2 VIL2 ICAM2 MSN IGFBP5 SPP1 IGFBP5 SERPINE1 IGFBP5 ADAM12 IGFBP5 PAPPA2 ITPR3 TRPC6 ITPR3 TRPC4 ITPR3 TRPC1 ITGB5 MYO10 ITGB5 PALLD ITGB5 TENC1 ISG15 USP18 IRF1 STAT1 IL6 IL6ST LAMC1 NID1 LAMC1 NID2 LMNA TMPO LMNA PCBP1 LMNA SYNE1 LMNA TOR1AIP1 ANXA1 DYSF ANXA2 CEACAM1 ANXA2 S100A6 ANXA2 CTSB ANXA2 PLAT ANXA2 DYSF ANXA2 S100A4 ALOX12 LMNA LOR VIM MAP4 MARK1 MAP4 MARK4 PTN SDC1 PTN SDC3 PTN SNCAIP PTN EIF3S5 PTN GADD45G PTN MYCBP PTN RIT1 PTN LUC7L2 NOS3 NOSTRIN HMGB1 PLAT HMGB1 MECP2 HMGB1 TLR4 HMGB1 CTCF HMGB1 SOX18 NFKB2 RELB EBF1 ZNF423 ETS1 GATA3 ETS1 ETS2 ETS1 FOS ETS1 JUN ETS1 STAT6 ETS1 STAT5B AKT2 HSP90AA1 ETS2 GATA3 ETS2 JUN ETS2 SMARCA4 ETS2 STAT5B FOS LMNA FOS JUN FOS JUNB FOS STAT1 FOS SUMO3 NOTCH4 PSEN2 NOTCH4 DLL4 NOTCH4 MAML1 FLT1 FYN FLT1 KDR FLT1 VEGFA FLT1 STAT1 FLT1 PGF FLT1 NRP1 RRAS RASIP1 LYN MME LYN PECAM1 LYN TEK LYN NPHS1 LYN GAB2 LYN SH2B2 JUN TOP1 JUN SKI JUN NFYA JUN STAT1 JUN SUMO3 JUN MAPK11 JUN PRKD1 JUN MAFB JUN TPM2 JUN SNRK RHOB FNTA RHOB ARHGEF3 SERPINE1 PLAT PLAT SPARC PLAT CLEC3B PDGFRB STAT1 PDGFRB STAT5B PDGFRB NCK2 PECAM1 PRKCE PCNA GADD45G KLK3 EPOR PROS1 TYRO3 PTPRB TEK EPHA2 TNFAIP1 EPHA2 SLA PRKCE AKAP9 PRKCE PRKD1 RRAD YWHAZ RRAD TPM2 RAP1A TCEB3 RAP1A SMARCA4 RAP1A RASA3 RAP1A RASGRP2 RAP1A RAPGEF5 RAP1A RASIP1 RAP2A MAP4K4 RAP2A RAPGEF5 RAP2A RASIP1 CLIP1 CLASP2 LMO2 TAL1 LMO2 STAT1 LMO2 JARID1A SPARC TGFB1 SPARC VEGFA KITLG PIK3CD VAMP2 STX11 VAMP2 VAPB LMO1 TAL1 TNC ITGA5 TNC PTPRB F2R GNAI2 TBXA2R YWHAZ TBXA2R RAB11A NFYA ZHX2 CEBPB CEBPD CEBPB EGR1 CEBPB HMGB1 CEBPB CREBBP CEBPB STAT6 CEBPB SMARCA4 E2F1 SP3 FES JAK3 FES RASA3 PDGFB PDGFRB TGFB1 TGFBR2 TGFB1 TGFBR3 TGFB1 EIF3S2 TGFB1 VASN TGFBR2 ARHGEF6 TGFBR2 TGFBR3 TGFBR2 EIF3S2 NOTCH1 PSEN2 NOTCH1 DLL4 NOTCH1 MAML1 TNNI1 CCDC85B MAP3K8 NFKB2 KDR TIMP3 KDR VEGFA KDR STAT1 KDR NRP1 UBE1L ISG15 VCAM1 VIL2 VEGFA NRP1 VIM YWHAZ VIM MICAL1 VIM PDLIM1 VIM SIAHBP1 VCL CORO2B C1R C1S CYBA NCF2 NCF2 S100A8 LPL UBE2Z LPL LUC7L2 MECP2 SKI FLNA SELE FLNA ITGB1 FLNA ITGB5 FLNA LMNA FLNA PSEN2 FLNA SH2B3 EFNB1 PTPN13 EFNB1 EPHB1 EFNB1 RGS3 EFNB1 NCK2 FHL1 FHL2 ARHGEF6 PARVB CRLF2 TSLP CHM RAB3B CHM RAB18 BGN TGFB1 IL2RG JAK3 IL2RG STAT1 MSN CD93 MSN VIL2 MSN VCAM1 SNTB2 DGKZ PTPN12 TGFB1I1 INPP5A YWHAZ CREBBP CSNK2A1 CREBBP CTNNB1 CREBBP EGR1 CREBBP NAP1L1 CREBBP EBF1 CREBBP ETS1 CREBBP ETS2 CREBBP JUN CREBBP EVI1 CREBBP E2F1 CREBBP RPS6KA3 CREBBP STAT1 CREBBP UBTF CREBBP STAT6 CREBBP FHL2 CREBBP RBBP4 CREBBP CITED2 CREBBP IRF7 CREBBP KLF13 CREBBP MAML1 CREBBP WT1 CREBBP NFIC CREBBP SERTAD1 CREBBP SERTAD3 CREBBP DACH1 JAK3 SOCS3 JAK3 SH2B2 DUSP3 EGF DUSP3 STAT1 AES HMGB1 AES PRDM1 AES SNCAIP AGER HMGB1 TEK TIE1 TEK DOK4 HIRA ASF1A PTPN13 YWHAZ ID3 IFI16 GPC1 VEGFA PPARD GADD45G PPARD HDAC7A FABP4 VIM EFNB2 PECAM1 EFNB2 PTPN13 EFNB2 EPHB1 EFNB2 RGS3 EFNB2 NCK2 STAT1 STAT5B PSME1 VIM PSME1 VCL PSME1 EMG1 MEF2C NOTCH1 MEF2C SOX18 MEF2C VGLL4 UBTF SMURF1 PTBP1 QKI IL6ST PLAUR IL6ST OSMR IL6ST SOCS3 DUSP1 MAPK12 GLG1 SELE GLG1 NFKB2 MMP14 SDC1 MMP14 TIMP2 MMP14 TIMP3 MMP14 SPOCK1 PSEN2 RAB11A CDKN1C PCNA CDKN1C NR4A2 GRK5 TBXA2R MYLK PAK1 KCNJ8 ABCC9 GNAQ TBXA2R GNAQ KDR GNAQ RGS2 GNAQ RGS4 GNAQ RGS5 TJP1 CLDN5 TJP1 JAM2 TJP1 KIRREL TJP1 TRPC4 VCP DERL1 FOXC1 HMGB1 MPP3 RPS2 MPP3 RAB31 CDH5 CTNNB1 CDH5 PTPRB CDH5 EPHA2 CDH5 KDR CDH5 VIM CDH5 PKP4 CDH5 SMG1 CDH5 P2RX4 PGF VEGFA PGF NRP1 SEMA3F VEGFA SEMA3F NRP1 RAN GADD45G RAN IPO11 CRIP2 PTPN13 CRIP2 PRKG1 PCBP1 PTBP1 PCBP1 SFRS3 PCBP1 PABPC1 PCBP1 QKI PCBP1 PCBP4 PCBP1 SIAHBP1 CD97 CD55 ACVRL1 TGFB1 ACVRL1 TGFBR2 YWHAZ RIN1 YWHAZ PARD3 YWHAZ MARK4 YWHAZ PARD6B CFL1 YWHAZ CFL1 MYCBP ING1 PCNA ING1 YWHAZ ING1 RBBP4 ING1 RBP1 OAZ1 OAZ2 LCP2 LYN NSF LUC7L2 BIRC3 CD40 BIRC3 DIABLO EDG3 GNAQ EDG1 PDGFRB RGS3 YWHAZ RGS3 MAPK12 HTRA1 GDF5 SUMO3 VIM CD151 ITGB1 CD151 ITGA3 PER1 TIMELESS ARVCF CDH2 ARVCF TJP1 TGFB1I1 TGFBR2 TGFB1I1 GIT2 PLD1 STXBP1 SERPINI1 PLAT K-ALPHA-1 EPN2 MAP3K3 YWHAZ MAP3K3 WNK1 JAG2 NOTCH1 MFNG NOTCH1 PAK1 TGFBR2 PAK1 ARHGEF6 PAK1 NCK2 PAK1 ABI3 PAK1 SMURF1 PAK1 GIT2 PAK1 PPM1F PAK1 ARPC1B PODXL SLC9A3R2 FHL2 ITGB1 FHL2 IGFBP5 FHL2 ITGB5 FHL2 PSEN2 FHL2 ITGA3 FHL2 WT1 TNFRSF11B TNFSF10 TNFRSF11B TNFSF13 PSMC6 FLJ38984 PSMC6 CCDC85B APBB2 SMURF1 ADAM12 SNX9 NPHS1 NPHS2 NPHS1 NCK2 NPHS1 KIRREL SEPT5 LSM8 PRKAB1 PRKAG1 DNAJA1 TM4SF1 IGFBP7 SDC1 IGFBP7 VEGFA RBBP4 SP3 RBBP4 MBD3 RBBP4 RBP1 SMAD6 SMURF1 SMAD6 TOB1 SGK SLC9A3R2 DHX9 JUN DHX9 PCNA SMARCA4 PB1 SMARCA4 CHMP5 CDK6 CDKN1A CDK6 PCNA MBD3 GATAD2A SNCAIP SH2D3C RNF7 ITM2C EIF3S5 PCID1 ITGA9 ITGB1 ITGA9 SPP1 AKAP9 FNBP1 DLG5 SORBS3 ACTR3 ARPC2 STAT5B TEK STAT5B STAP2 CBLB FYN CBLB NCK2 CBLB SORBS3 ACTN4 ITGB1 ACTN4 GSN ACTN4 SLC9A3R2 ACTN4 PDLIM1 PABPC1 PAIP2 NPHS2 KIRREL GADD45B PCNA GADD45B PPARD GADD45B GADD45G GADD45G LUC7L2 ITGA3 ITGB1 ITGA3 TIMP2 ITGA3 TSPAN4 PRKD1 HDAC7A PRKCH PRKD1 ADAM15 SNX9 PARD3 PARD6B SCARF1 SCARF2 QKI SERF2 QKI C10orf10 QKI RBM9 QKI PCBP4 HSP90AB1 NR2C2 HSP90AB1 MAP3K3 ATF4 JUN ATF4 CEBPB ATF4 POLR2C HHEX JUN RELB SMARCA4 SMURF1 CDGAP UBC UCHL1 UBC YWHAZ UBC OTUD7B UBC DLGAP4 BNIP3L STEAP3 TSC22D1 CORO2B MYCBP CPNE2 ST13 ASF1A GOLPH2 ZFAND3 CHMP6 VPS25 EDNRB NOS3 MCL1 PCNA PBX1 PBX2 PTGDS PTGER2 PRKG1 SPP1 PRKG1 RGS2 PRKG1 MRVI1 CD81 TSPAN4 CD81 DLG5 CD81 IFITM1 UPP1 VIM ID1 IFI16 PCSK5 PTPRM PCSK5 REN INPP5D LYN INPP5D PECAM1 INPP5D JAK3 INPP5D GAB2 HSPB1 TGFB1I1 HSPB1 HSPB8 CLIP2 CLASP2 MPP5 PARD6B PRKD2 HDAC7A MORF4L1 MRFAP1L1 ARL6IP1 SKIP RAB3IL1 RAB11A RIT1 SMURF1 STYX CARHSP1 ITGA8 NPNT ARPC1B ARPC2 ARPC4 ACTR3 ARPC4 ARPC1B ARPC4 ARPC2 SORBS3 DDX17 CALCRL RAMP2 CALCRL RAMP3 TRPC1 TRPC4 GNG11 SMURF1 PLEKHO1 SMURF1 C10orf10 USHBP1 SERTAD3 USHBP1 S100A4 SEPT6 S100A4 TPM2 CCDC85B EXOC8 CCDC85B C21orf91 CCDC85B C10orf10 CCDC85B FAM13C1 GPSM1 USHBP1 LUC7L2 NDUFA4L2 NDRG2 HCCA2 SIAHBP1 SAP30BP USHBP1 FLJ38984 USHBP1 EXOC8 PARD6B PARD3B