Datasheet Inhibitors / Agonists / Screening Libraries A D RUG SCREEN IN G EXPERT

Product Name : Brivudine Catalog Number : T0718 CAS Number : 69304-47-8 Molecular Formula : C11H13BrN2O5 Molecular Weight : 333.14 Appearance : Solid Melting Point : 165°C

Description: Brivudine, an antiviral medicine, is used in the therapy of herpes zoster.

Storage: 2 years -80°C in solvent; 3 years -20°C powder;

DMSO 330 mg/mL Solubility ( < 1 mg/ml refers to the product slightly soluble or insoluble )

HSV-1 Receptor (IC50) VZV

In vitro Activity Brivudine is an analog of thymidine, and is incorporated into the viral DNA. It blocks the action of DNA polymerases, thus inhibiting viral replication. It has a stronger antiviral effect against the varicella-zoster virus compared with reference compounds such as aciclovir or penciclovir[1]. It has high, selective activity against varicella zoster virus (VZV), inhibiting VZV replication, possibly through competitive inhibition of viral DNA polymerase, or by acting as an alternative substrate to deoxythymidine triphosphate, causing viral DNA strand breakage[2].

In vivo Activity At a dose of 125 mg once daily, brivudine has proved to be superior to aciclovir with respect to reducing the period of new blister production, and has shortened the duration of post-herpetic neuralgia[1].

Reference 1. Rabasseda X, et al. Brivudine: a herpes virostatic with rapid antiviral activity and once-daily dosing. Drugs Today (Barc). 2003 May;39(5):359-71. 2. Keam SJ, et al. Brivudin (bromovinyl deoxyuridine). Drugs. 2004;64(18):2091-7; discussion 2098-9.

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