Interactions with HBV Treatment

www.hep-druginteractions.org

Charts revised September 2021. Full information available at www.hep-druginteractions.org Page 1 of 6 Please note that if a drug is not listed it cannot automatically be assumed it is safe to coadminister. ADV, Adefovir; ETV, Entecavir; LAM, Lamivudine; PEG IFN, Peginterferon; RBV, Ribavirin; TBV, Telbivudine; TAF, Tenofovir alafenamide; TDF, Tenofovir-DF.

ADV ETV LAM PEG PEG RBV TBV TAF TDF ADV ETV LAM PEG PEG RBV TBV TAF TDF IFN IFN IFN IFN alfa-2a alfa-2b alfa-2a alfa-2b Anaesthetics & Muscle Relaxants Antibacterials (continued) Bupivacaine ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Cloxacillin ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Cisatracurium ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Dapsone ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Isoflurane ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Delamanid ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Ketamine ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Ertapenem ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Nitrous oxide ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Erythromycin ◆ ◆ ◆ ◆ ◆ ◆  ◆ ◆ Propofol ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Ethambutol ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Thiopental ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Flucloxacillin ◆ ◆ ◆ ◆ ◆ ◆ Tizanidine ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Gentamicin   ◆ ◆ ◆ ◆ ◆ ◆  Analgesics Imipenem   ◆ ◆ ◆ ◆ ◆ ◆ ◆ Aceclofenac ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆  Isoniazid ◆ ◆ ◆ ◆ ◆ ◆ Alfentanil ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Levofloxacin ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Aspirin ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆  Linezolid ◆ ◆ ◆    ◆ ◆ ◆ Buprenorphine ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Lymecycline ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Celecoxib ◆ ◆ ◆ ◆ ◆  ◆ ◆  Meropenem   ◆ ◆ ◆ ◆ ◆ ◆  Codeine ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆

for distribution. for Methenamine ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Dexketoprofen ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆  Metronidazole ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Dextropropoxyphene ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Moxifloxacin ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Diamorphine ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Nitrofurantoin ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Diclofenac ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆  Norfloxacin ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Diflunisal ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Ofloxacin ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Dihydrocodeine ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Penicillin V ◆ ◆ ◆ ◆ ◆ ◆ Etoricoxib ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆  Piperacillin ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Fentanyl ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Pivmecillinam ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Flurbiprofen ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆  Pyrazinamide ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Hydrocodone ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Rifabutin ◆ ◆ ◆ ◆ ◆ ◆ ◆  ◆ Hydromorphone ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Rifampicin ◆ ◆ ◆ ◆ ◆ ◆ ◆  ◆ Ibuprofen ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆  Rifapentine ◆ ◆ ◆ ◆ ◆ ◆ ◆  ◆ Indometacin ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆  Ketoprofen ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆  Rifaximin ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Mefenamic acid ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆  Spectinomycin ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Meloxicam ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆  Streptomycin ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆  Metamizole (Dipyrone) ◆ ◆ ◆ ⚫ ⚫ ⚫ ◆ ◆ ◆ Sulfadiazine ◆ ◆ ◆ ◆ ◆ ◆ ◆  Methadone ◆ ◆ ◆   ◆ ◆ ◆ ◆ Tazobactam   ◆ ◆ ◆ ◆ ◆ ◆  Morphine ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Telithromycin ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Naproxen ◆ ◆ ◆ ◆ ◆ ◆ ◆  Temocillin ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Oxycodone ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Tetracyclines ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Paracetamol ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Ticarcillin ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Pethidine (Meperidine) ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Trimethoprim/Sulfamethoxazole ◆ ◆  ◆ ◆ ◆ ◆ ◆ ◆ Piroxicam ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆  Troleandomycin ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Tapentadol ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Vancomycin ◆ ◆ ◆ ◆ ◆ ◆  Tramadol ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Anticoagulant, Antiplatelet & Fibrinolytic Anthelmintics Acenocoumarol ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Albendazole ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Anagrelide ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Ivermectin ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Apixaban ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Oxamniquine ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Clopidogrel ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Praziquantel ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Dabigatran ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Pyrantel ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Dalteparin ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Antiarrhythmics Danaparoid ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Amiodarone ◆ ◆ ◆ ◆ ◆ ◆ ◆   Dipyridamole ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Bepridil ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Edoxaban ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Digoxin ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Eltrombopag ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Disopyramide ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Enoxaparin ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Dofetilide ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Fluindione ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Dronedarone ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Fondaparinux ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Flecainide ◆ ◆ ◆ ◆  ◆ ◆ ◆ ◆ Heparin ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Lidocaine (Lignocaine) ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Phenprocoumon ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Mexiletine ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Prasugrel ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Propafenone ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Rivaroxaban ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Quinidine ◆ ◆ ◆ ◆ ◆ ◆ ◆   Streptokinase ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Vernakalant ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Ticagrelor ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Antibacterials Ticlopidine ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Amikacin  ◆ ◆ ◆ ◆ ◆ ◆  Tinzaparin ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Amoxicillin ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Warfarin ◆ ◆ ◆    ◆ ◆ ◆ Ampicillin ◆ ◆ ◆ ◆ ◆ Anticonvulsants Azithromycin ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Carbamazepine ◆ ◆ ◆ ◆ ◆ ◆ ◆ ⚫ ◆ Aztreonam ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Clonazepam ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Bedaquiline ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Eslicarbazepine ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Benzylpenicillin ◆ ◆ ◆ ◆ ◆ ◆ Ethosuximide ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Capreomycin ◆ ◆ ◆ ◆ ◆  For personal use only. Not for distribution. For personal use only. Not for distribution. For personal use only. Not Not only. use personal For distribution. for Not use only. personal For distribution. for Not only. use personal For Gabapentin ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Cefaclor ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Lacosamide ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Cefadroxil ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Cefalexin   ◆ ◆ ◆ ◆ ◆ ◆  Lamotrigine Cefazolin ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Levetiracetam ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Cefixime ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Oxcarbazepine ◆ ◆ ◆ ◆ ◆ ◆ ◆ ⚫ ◆ Cefotaxime ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Perampanel ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Cefradine ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Phenobarbital ◆ ◆ ◆ ◆ ◆ ◆ ◆ ⚫ ◆ Ceftaroline ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Phenytoin ◆ ◆ ◆ ◆  ◆ ◆ ⚫ ◆ Ceftazidime ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Pregabalin ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Ceftriaxone ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Primidone ◆ ◆ ◆ ◆ ◆ ◆ ◆ ⚫ ◆ Cefuroxime ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Retigabine ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Chloramphenicol ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Rufinamide ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Ciprofloxacin ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Sultiame ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Clarithromycin ◆ ◆ ◆ ◆ ◆ ◆ ◆   Tiagabine ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Clavulanic acid ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Topiramate ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆  Clindamycin ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Valproate (Divalproex) ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Clofazimine ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Vigabatrin ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Zonisamide ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆

Key to symbols Notes ➢ Further information is available at © Liverpool Drug Interactions Group, ⚫ These drugs should not be coadministered www.hep-druginteractions.org University of Liverpool, Pharmacology Research Labs, Potential clinically significant interaction that is likely to require additional ➢ Predicted interactions are based on known 1st Floor Block H, 70 Pembroke Place, LIVERPOOL, L69 3GF  monitoring, alteration of drug dosage or timing of administration metabolic pathways and routes of clearance. We aim to ensure that information is accurate and consistent with current knowledge Potential interaction likely to be of weak intensity. Additional ➢ Caution is required in patients with hepatic and practice. However, the University of Liverpool and its servants or agents shall action/monitoring or dosage adjustment is unlikely to be required impairment as this may also increase drug levels not be responsible or in any way liable for the continued currency of information in and require dose modification. this publication whether arising from negligence or otherwise howsoever or for any ◆ No clinically significant interaction expected ➢ Where advice differs between countries, the consequences arising therefrom. The University of Liverpool expressly exclude liability for errors, omissions or inaccuracies to the fullest extent permitted by law.

charts reflect the more cautious option.

www.hep-druginteractions.org

Interactions with HBV Treatment

Charts revised September 2021. Full information available at www.hep-druginteractions.org Page 2 of 6 Please note that if a drug is not listed it cannot automatically be assumed it is safe to coadminister. ADV, Adefovir; ETV, Entecavir; LAM, Lamivudine; PEG IFN, Peginterferon; RBV, Ribavirin; TBV, Telbivudine; TAF, Tenofovir alafenamide; TDF, Tenofovir-DF.

ADV ETV LAM PEG PEG RBV TBV TAF TDF ADV ETV LAM PEG PEG RBV TBV TAF TDF IFN IFN IFN IFN alfa-2a alfa-2b alfa-2a alfa-2b Antidepressants Antihistamines Agomelatine ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Astemizole ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Amitriptyline ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Bilastine ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Bupropion ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Cetirizine ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Citalopram ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Chlorphenamine ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Clomipramine ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Desloratadine ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Desipramine ◆ ◆ ◆ ◆  ◆ ◆ ◆ ◆ Diphenhydramine ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Desvenlafaxine ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Doxylamine ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Dosulepin ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Ebastine ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Doxepin ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Fexofenadine ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Duloxetine ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Hydroxyzine ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Escitalopram ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Levocetirizine Loratadine ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Fluoxetine ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Promethazine ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Fluvoxamine ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Terfenadine ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆

Imipramine ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ distribution. for Lithium ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆  Antimigraine Agents Almotriptan ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Maprotiline ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Dihydroergotamine ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Mianserin ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Eletriptan ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Milnacipran ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Ergotamine ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Mirtazapine ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Frovatriptan ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Moclobemide ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Methylergonovine ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Nefazodone ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Naratriptan ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Nortriptyline ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Pizotifen ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Paroxetine ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Rizatriptan ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Sertraline ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Sumatriptan ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Tianeptine ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Zolmitriptan ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Trazodone ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Antiprotozoals Trimipramine ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Amodiaquine ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Venlafaxine ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Artemether ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Vortioxetine ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Artemisinin ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Antidiabetics Artesunate ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Acarbose ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Atovaquone ◆ ◆ ◆    ◆ ◆ ◆ Albiglutide ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Chloroquine ◆ ◆ ◆ ◆ ◆ ◆  ◆ ◆ Alogliptin ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Dihydroartemisinin ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Canagliflozin ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆  Doxycycline ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Dapagliflozin ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Halofantrine ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Dulaglutide ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Hydroxychloroquine ◆ ◆ ◆ ◆ ◆ ◆  ◆ ◆ Empagliflozin ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆  Lumefantrine ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆   ◆ ◆ ◆ ◆ Exenatide ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Mefloquine Nitazoxanide ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Glibenclamide (Glyburide) ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Pentamidine ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆  Gliclazide ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Primaquine ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Glimepiride ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Proguanil ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Glipizide ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Pyrimethamine ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Insulin ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Quinine ◆ ◆ ◆   ◆ ◆ ◆ ◆ Linagliptin ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Sodium stibogluconate ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Liraglutide ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Sulfadoxine ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Lixisenatide ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Antipsychotics/Neuroleptics Metformin ◆ ◆ ◆ ◆ ◆ ◆  ◆ ◆ Amisulpride ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Nateglinide ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Aripiprazole ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Pioglitazone ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Asenapine ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Repaglinide ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Chlorpromazine ◆ ◆ ◆   ◆ ◆ ◆ ◆ Rosiglitazone ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Chlorprothixene ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Saxagliptin ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Clozapine ◆ ◆ ◆    ◆ ◆ ◆   Sitagliptin ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Flupentixol ◆ ◆ ◆ ◆ ◆ ◆ ◆ Fluphenazine ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Tolbutamide ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Haloperidol ◆ ◆ ◆   ◆ ◆ ◆ ◆ Vildagliptin ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Iloperidone ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Antifungals Levomepromazine ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Amphotericin B ◆ ◆ ◆    ◆ ◆  Lurasidone ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Anidulafungin ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Olanzapine ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Caspofungin ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Paliperidone ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Fluconazole ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Perazine ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Flucytosine    ◆ ◆ ◆ ◆ ◆  Periciazine ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆

Griseofulvin ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Not only. use personal For distribution. for Not use only. personal For distribution. for Not only. use personal For Perphenazine ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Isavuconazole ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Pimozide ◆ ◆ ◆   ◆ ◆ ◆ ◆ Itraconazole ◆ ◆ ◆ ◆ ◆ ◆ ◆   Pipotiazine ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Ketoconazole ◆ ◆ ◆ ◆ ◆ ◆ ◆   Prochlorperazine ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Miconazole ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Quetiapine ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Risperidone ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Nystatin ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Sulpiride ◆ ◆ ◆   ◆ ◆ ◆ ◆ Posaconazole ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Thioridazine ◆ ◆ ◆   ◆ ◆ ◆ ◆ Terbinafine ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Tiapride ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Voriconazole ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Trifluoperazine ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Ziprasidone ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Zuclopentixol ◆ ◆ ◆   ◆ ◆ ◆ ◆

charts reflect the more cautious option.

www.hep-druginteractions.org

Interactions with HBV Treatment

Charts revised September 2021. Full information available at www.hep-druginteractions.org Page 3 of 6 Please note that if a drug is not listed it cannot automatically be assumed it is safe to coadminister. ADV, Adefovir; ETV, Entecavir; LAM, Lamivudine; PEG IFN, Peginterferon; RBV, Ribavirin; TBV, Telbivudine; TAF, Tenofovir alafenamide; TDF, Tenofovir-DF.

ADV ETV LAM PEG PEG RBV TBV TAF TDF ADV ETV LAM PEG PEG RBV TBV TAF TDF IFN IFN IFN IFN alfa-2a alfa-2b alfa-2a alfa-2b Antivirals Cancer Therapies Aciclovir   ◆ ◆ ◆ ◆ ◆ ◆  Abiraterone ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Amantadine ◆ ◆    ◆ ◆ ◆ Acalabrutinib ◆ ◆ ◆    ◆ ◆ ◆ Brivudine ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Anastrozole ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Cidofovir   ◆    ◆ ◆  Avelumab ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Favipiravir ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆  Axitinib ◆ ◆ ◆    ◆ ◆ ◆ Foscarnet ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆  Bevacizumab ◆ ◆ ◆    ◆ ◆ ◆ Oseltamivir   ◆ ◆ ◆ ◆ ◆ ◆ ◆ Blinatumomab ◆ ◆ ◆    ◆ ◆ ◆ Remdesivir ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Bortezomib ◆ ◆ ◆    ◆ ◆ ◆ Rimantadine ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Bosutinib ◆ ◆ ◆    ◆ ◆ ◆ Valaciclovir   ◆ ◆ ◆ ◆ ◆ ◆  Brentuximab vedotin ◆ ◆ ◆    ◆ ◆ ◆ Zanamivir ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Capecitabine ◆    ◆ Anxiolytics/Hypnotics/Sedatives Carboplatin ◆ ◆ ◆    ◆ ◆  Alprazolam ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Cetuximab ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆

Amobarbital ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Chlorambucil ◆ ◆ ◆    ◆ ◆ ◆ for distribution. for Bromazepam ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Cisplatin       ◆ ◆  Bromperidol ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Cyclophosphamide ◆ ◆ ◆  ◆ ◆ ◆ Buspirone ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Daratumumab ◆ ◆ ◆    ◆ ◆ ◆ Clobazam ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Dasatinib ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Clorazepate ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Doxorubicin ◆ ◆ ◆    ◆ ◆ ◆ Clotiapine ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Erlotinib ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Diazepam ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Estramustine ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Estazolam ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Etoposide ◆ ◆ ◆    ◆ ◆ ◆ Flurazepam ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Everolimus ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Lorazepam ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Exemestane ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Lormetazepam ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Fludarabine ◆ ◆ ◆    ◆ ◆ ◆ Midazolam (oral) ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Gefitinib ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Midazolam (parenteral) ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Gemcitabine ◆ ◆ ◆    ◆ ◆ ◆ Oxazepam ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Idarubicin ◆ ◆ ◆    ◆ ◆ ◆ Quazepam ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Imatinib ◆ ◆ ◆    ◆ ◆ ◆ Temazepam ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Ipilimumab ◆ ◆ ◆    ◆ ◆ ◆ Triazolam ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Irinotecan ◆ ◆ ◆    ◆ ◆ ◆ Zaleplon ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Ixazomib ◆ ◆ ◆    ◆ ◆ ◆ Zolpidem ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Lapatinib ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Zopiclone ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Letrozole ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Medroxyprogesterone Beta Blockers ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Atenolol ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ (oncology) Bisoprolol ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Mercaptopurine ◆ ◆ ◆   ⚫ ◆ ◆ ◆ Carvedilol ◆ ◆ ◆    ◆ ◆ ◆ Mesna   ◆ ◆ ◆ ◆ ◆ ◆  Celiprolol ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Methotrexate   ◆    ◆ ◆  ◆ ◆ ◆    ◆ ◆ ◆ Labetalol ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Mitoxantrone Nilotinib ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Metoprolol ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Niraparib ◆ ◆ ◆    ◆ ◆ ◆ Nebivolol ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Nivolumab ◆ ◆ ◆    ◆ ◆ ◆ Oxprenolol ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Obinutuzumab ◆ ◆ ◆   ◆ ◆ ◆ ◆ Pindolol ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Ofatumumab ◆ ◆ ◆    ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Propranolol Olaratumab ◆ ◆ ◆    ◆ ◆ ◆ Sotalol ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Oxaliplatin    ◆ ◆  Timolol ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Paclitaxel ◆ ◆ ◆    ◆ ◆ ◆ Bisphosphonates Panitumumab ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Alendronic acid ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Rituximab ◆ ◆ ◆    ◆ ◆ ◆ Clodronate ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Ruxolitinib ◆ ◆ ◆    ◆ Ibandronic acid ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Sunitinib ◆ ◆ ◆    ◆ ◆ ◆ Pamidronate ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Tamoxifen ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Risedronate ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Temsirolimus ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Bronchodilators Vinblastine ◆ ◆ ◆    ◆ ◆ ◆ Formoterol ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Vincristine ◆ ◆ ◆    ◆ ◆ ◆ Indacaterol ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Vinorelbine ◆ ◆ ◆    ◆ ◆ ◆ Ipratropium bromide ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Contraceptives and Hormone Replacements Conjugated estrogens Montelukast ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Omalizumab ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ (HRT) Salbutamol ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Desogestrel (POP) ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Desogestrel/ethinylestradiol Salmeterol ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Theophylline ◆ ◆ ◆   ◆ ◆ ◆ ◆ (COC) Tiotropium ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Dienogest ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Drospirenone (POP) ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Calcium Channel Blockers

Amlodipine ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Not only. use personal For distribution. for Not use only. personal For distribution. for Not only. use personal For Drospirenone/estradiol (HRT) ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Drospirenone/ Diltiazem ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ethinylestradiol (COC) Felodipine ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Dydrogesterone/estradiol Nicardipine ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ (HRT) Nifedipine ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Estradiol ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Nisoldipine ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Ethinylestradiol ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Nitrendipine ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Etonogestrel (implant) ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Verapamil ◆ ◆ ◆ ◆ ◆ ◆ ◆   Etonogestrel (vaginal ring) ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Gestodene/ethinylestradiol ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ (COC) Levonorgestrel ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ (Emergency Contraception)

charts reflect the more cautious option.

www.hep-druginteractions.org

Interactions with HBV Treatment

Charts revised September 2021. Full information available at www.hep-druginteractions.org Page 4 of 6 Please note that if a drug is not listed it cannot automatically be assumed it is safe to coadminister. ADV, Adefovir; ETV, Entecavir; LAM, Lamivudine; PEG IFN, Peginterferon; RBV, Ribavirin; TBV, Telbivudine; TAF, Tenofovir alafenamide; TDF, Tenofovir-DF.

ADV ETV LAM PEG PEG RBV TBV TAF TDF ADV ETV LAM PEG PEG RBV TBV TAF TDF IFN IFN IFN IFN alfa-2a alfa-2b alfa-2a alfa-2b Contraceptives and Hormone Replacements (continued) HCC Therapies Levonorgestrel (HRT) ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Lenvatinib ◆ ◆ ◆ ◆ ◆ ◆ Levonorgestrel (implant) ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Pembrolizumab ◆ ◆ ◆  ◆ ◆ ◆ Levonorgestrel (IUD) ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Regorafenib ◆ ◆ ◆ ◆ ◆ ◆ Levonorgestrel (POP) ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Sorafenib ◆ ◆ ◆ ◆ ◆ ◆ Levonorgestrel/ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Hepatitis B Drugs ethinylestradiol (COC) Adefovir ◆   ◆ ◆ ⚫ ⚫ Medroxyprogesterone (depot) ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Entecavir ◆ ◆ ◆ ◆ ◆ ◆ ◆ Medroxyprogesterone (oral) ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Lamivudine ◆ ◆     ◆ ◆ Medroxyprogesterone/ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Peginterferon alfa-2a  ◆  n/a ◆ ⚫   conjugated estrogens (HRT) Peginterferon alfa-2b  ◆  n/a ◆ ⚫   Medroxyprogesterone/ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Ribavirin ◆ ◆  ◆ ◆ ◆   estradiol (HRT) Telbivudine ◆ ◆  ⚫ ⚫ ◆ ◆  Norelgestromin/ethinylestradiol ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Tenofovir alafenamide (TAF) ⚫ ◆ ◆    ◆ ⚫ (patch) Tenofovir-DF ⚫ ◆ ◆     ⚫ Norethisterone distribution. for ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ (Norethindrone) (depot injection) Hepatitis C Drugs (Direct Acting Antivirals) Norethisterone Daclatasvir ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ (Norethindrone) (POP) Elbasvir/Grazoprevir ◆ ◆ ◆   ◆ ◆ ◆ ◆ Norethisterone Glecaprevir/Pibrentasvir ◆ ◆ ◆   ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ (Norethindrone)/estradiol (HRT) Ledipasvir/Sofosbuvir ◆ ◆ ◆   ◆ ◆ ◆  Norethisterone OBV/PTV/r ◆ ◆ ◆   ◆ ◆  ◆ (Norethindrone)/ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ OBV/PTV/r + Dasabuvir ◆ ◆ ◆   ◆ ◆  ◆ ethinylestradiol (COC) Simeprevir ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Norethisterone Sofosbuvir (SOF) ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ (Norethindrone)/mestranol ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ SOF/Velpatasvir ◆ ◆ ◆   ◆ ◆ ◆  (COC) SOF/Velpatasvir/Voxilaprevir ◆ ◆ ◆    ◆ ◆  Norgestimate/ethinylestradiol ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Hepatitis D Entry Inhibitor (COC) Bulevirtide ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Norgestrel/conjugated ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ estrogens (HRT) Herbals/Supplements/Vitamins Aloe vera ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Norgestrel/ethinylestradiol ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ (COC) Ascorbic acid (Vitamin C) ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Black cohosh (A. racemosa) ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Erectile Dysfunction Agents Sildenafil ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Cat’s claw (U. tomentosa) ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Tadalafil ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Colecalciferol (Vitamin D3) ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Vardenafil ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Cyanocobalamin (B12) ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Diosmin ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Gastrointestinal Agents Echinacea ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Aluminium hydroxide ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Eucalyptus globulus ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Alverine citrate ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Ferrous sulphate ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Antacids ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Folic acid ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Aprepitant ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Garlic ◆ ◆ ◆ ◆ ◆ ◆ ◆  ◆ Bisacodyl ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Ginger (Z. officinale) ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Cimetidine ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆  Ginkgo biloba ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Cisapride ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Ginseng ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Cyclizine ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Goldenseal (H. canadensis) ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Dantron ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Grape seed extract ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Domperidone ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Grapefruit juice ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Droperidol ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Green tea (C. sinensis) ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Esomeprazole ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Homeopathic remedies ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Famotidine ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Inula racemosa ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Granisetron ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Heroin ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Hyoscine ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Iodine ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Ispaghula husk ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Kava kava (P. methysticum) ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Lactulose ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Milk thistle ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Lansoprazole ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Retinol (Vitamin A) ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Linaclotide ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Riboflavin (Vitamin B2) ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Loperamide ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Serenoa repens ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Lubiprostone ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ St John’s wort ◆ ◆ ◆   ◆ ◆ ⚫ ◆ Macrogol ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Thiamine (Vitamin B1) ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Mebeverine ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Turmeric (curcumin) ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Mesalazine ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Valerian ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Methylcellulose ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Vitamin E ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Metoclopramide ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Naloxegol ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆

Omeprazole ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆

Ondansetron ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ For personal use only. Not for distribution. For personal use only. Not for distribution. For personal use only. Not Not only. use personal For distribution. for Not use only. personal For distribution. for Not only. use personal For Pantoprazole ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Prucalopride ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Rabeprazole ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Ranitidine ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Senna ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Simeticone ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Sulfasalazine ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Trimebutine ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆

charts reflect the more cautious option.

www.hep-druginteractions.org

Interactions with HBV Treatment

Charts revised September 2021. Full information available at www.hep-druginteractions.org Page 5 of 6 Please note that if a drug is not listed it cannot automatically be assumed it is safe to coadminister. ADV, Adefovir; ETV, Entecavir; LAM, Lamivudine; PEG IFN, Peginterferon; RBV, Ribavirin; TBV, Telbivudine; TAF, Tenofovir alafenamide; TDF, Tenofovir-DF.

ADV ETV LAM PEG PEG RBV TBV TAF TDF ADV ETV LAM PEG PEG RBV TBV TAF TDF IFN IFN IFN IFN alfa-2a alfa-2b alfa-2a alfa-2b HIV Drugs Hypertension/Heart Failure Agents Entry/Integrase Inhibitors Acebutolol ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Bictegravir/FTC/TAF ⚫ ◆ ⚫     ⚫ ⚫ Aliskiren ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Dolutegravir ◆ ◆ ◆ ◆ ◆ ◆  ◆ ◆ Ambrisentan ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Dolutegravir/rilpivirine ◆ ◆  ◆ ◆ ◆    Amiloride ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Azilsartan ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Elvitegravir/cobi /FTC/TAF ⚫ ◆ ⚫     ⚫ ⚫ Benazepril ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Elvitegravir/cobi/FTC/TDF ⚫ ◆ ⚫     ⚫ ⚫ Bendroflumethiazide ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆  Ibalizumab-uiyk ◆ ◆ ◆ ◆ ◆ ◆  ◆ ◆ Bosentan ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Maraviroc ◆ ◆ ◆ ◆ ◆ ◆  ◆ ◆ Bumetanide   ◆ ◆ ◆ ◆ ◆ ◆  Raltegravir ◆ ◆ ◆ ◆ ◆ ◆  ◆ ◆ Candesartan ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ NNRTIs Captopril   ◆ ◆ ◆ ◆ ◆ ◆ ◆ Dolutegravir/rilpivirine ◆ ◆  ◆ ◆ ◆    Chlorothiazide ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆  Doravirine ◆ ◆ ◆ ◆ ◆ ◆  ◆ ◆ Chlortalidone ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Doravirine/3TC/TDF ⚫ ◆ ⚫     ⚫ ⚫ Cilazapril ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Efavirenz ◆ ◆ ◆ ◆ ◆ ◆  ◆ ◆ Clevidipine ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆

for distribution. for Clonidine ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Etravirine ◆ ◆ ◆ ◆ ◆ ◆  ◆ ◆ Doxazosin ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Nevirapine ◆ ◆ ◆ ◆ ◆ ◆  ◆ ◆ Enalapril ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Rilpivirine ◆ ◆ ◆ ◆ ◆ ◆  ◆ ◆ Eplerenone ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Rilpivirine/FTC/TAF ⚫ ◆ ⚫   ◆  ⚫ ⚫ Epoprostenol ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ NRTIs Eprosartan ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Abacavir ◆ ◆ ◆     ◆ ◆ Fosinopril ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Didanosine ◆ ◆ ◆ ⚫ ⚫ ⚫   ⚫ Furosemide   ◆ ◆ ◆ ◆ ◆ ◆ Emtricitabine (FTC)  ◆ ⚫     ◆ ◆ Hydralazine ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆  Emtricitabine + TAF ⚫ ◆ ⚫     ⚫ ⚫ Hydrochlorothiazide ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Iloprost ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Emtricitabine + TDF ⚫ ◆ ⚫   ◆  ⚫ ⚫ Indapamide ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆     Lamivudine ◆ ◆ ◆ ◆ ◆ Irbesartan ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Stavudine  ◆ ◆   ⚫  ◆ ◆ Isradipine ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Tenofovir-DF ⚫ ◆ ◆     ⚫ Ivabradine ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Zidovudine ◆ ◆ ◆ ⚫ ⚫ ⚫  ◆ ◆ Lacidipine ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Protease Inhibitors Lercanidipine ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Atazanavir alone ◆ ◆ ◆ ◆ ◆    ⚫ Lisinopril ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Atazanavir/cobicistat ◆ ◆ ◆ ◆ ◆     Losartan ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Atazanavir + ritonavir ◆ ◆ ◆ ◆ ◆     Macitentan ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Darunavir/cobicistat ◆ ◆ ◆ ◆ ◆ ◆    Methyldopa ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Metolazone ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Darunavir/cobi/FTC/TAF ⚫ ◆ ⚫   ◆  ⚫ ⚫ Moxonidine ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Darunavir + ritonavir ◆ ◆ ◆ ◆ ◆ ◆    Olmesartan ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Fosamprenavir ◆ ◆ ◆ ◆ ◆ ◆    Perindopril ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Indinavir ◆ ◆ ◆ ◆ ◆ ◆    Prazosin ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Lopinavir ◆ ◆ ◆ ◆ ◆ ◆    Quinapril ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Ritonavir ◆ ◆ ◆ ◆ ◆ ◆    Ramipril ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Tipranavir ◆ ◆ ◆ ◆ ◆ ◆  ⚫  Ranolazine ◆ ◆ ◆ ◆ ◆ ◆ ◆   Rilmenidine ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Riociguat ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Selexipag ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Sildenafil ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Spironolactone ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Tadalafil ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Telmisartan ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Torasemide ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Trandolapril ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Treprostinil ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Valsartan ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Xipamide ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Zofenopril ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆

For personal use only. Not for distribution. For personal use only. Not for distribution. For personal use only. Not Not only. use personal For distribution. for Not use only. personal For distribution. for Not only. use personal For

charts reflect the more cautious option.

www.hep-druginteractions.org

Interactions with HBV Treatment

Charts revised September 2021. Full information available at www.hep-druginteractions.org Page 6 of 6 Please note that if a drug is not listed it cannot automatically be assumed it is safe to coadminister. ADV, Adefovir; ETV, Entecavir; LAM, Lamivudine; PEG IFN, Peginterferon; RBV, Ribavirin; TBV, Telbivudine; TAF, Tenofovir alafenamide; TDF, Tenofovir-DF.

ADV ETV LAM PEG PEG RBV TBV TAF TDF ADV ETV LAM PEG PEG RBV TBV TAF TDF IFN IFN IFN IFN alfa-2a alfa-2b alfa-2a alfa-2b Illicit/Recreational Other Drugs Alcohol ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Acamprosate ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Amphetamine ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Acetazolamide   ◆ ◆ ◆ ◆ ◆ ◆  Cannabis ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Acitretin ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Carfentanil ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Activated charcoal ◆ ◆    Cocaine ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Allopurinol ◆ ◆ ◆ ◆ ◆ ◆ Atomoxetine ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Ecstasy (MDMA) ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Atropine ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆

GHB (Gamma-hydroxybutyrate) ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Baclofen ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Heroin ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Bamlanivimab ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ LSD (Lysergic acid diethylamide) ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Benralizumab ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Mephedrone ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Betahistine ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Methamphetamine ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Bimatoprost ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Phencyclidine (PCP) ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Biperiden ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆

Immunosuppressants Brinzolamide ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ for distribution. for Adalimumab ◆ ◆ ◆  ◆ ◆ ◆ Bromocriptine ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Alemtuzumab ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Calcitonin ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Anakinra ◆ ◆ ◆    ◆ ◆ ◆ Calcium carbimide ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Calcium resonium ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Azathioprine ◆ ◆ ◆    ◆ ◆ ◆ Cannabidiol ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Baricitinib ◆ ◆ ◆    ◆ ◆ ◆ Carbimazole ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Basiliximab ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Carisoprodol ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Brodalumab ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Casirivimab/imdevimab ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Canakinumab ◆ ◆ ◆    ◆ ◆ ◆ Cilostazol ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Ciclosporin ◆ ◆ ◆ ◆ ◆ ◆    Clomifene ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Eculizumab ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Colchicine ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Etanercept ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Colestyramine ◆ ◆ Fingolimod ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Conivaptan ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Lenalidomide ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Convalescent plasma (COVID- ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ 19) Mycophenolate ◆ ◆ ◆    ◆ ◆  COVID-19 vaccinations ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Pirfenidone ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Cyclobenzaprine ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Sarilumab ◆ ◆ ◆    ◆ ◆ ◆ Cytisine ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Sirolimus ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Darbepoetin ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Tacrolimus ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Deferiprone ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Tocilizumab ◆ ◆ ◆    ◆ ◆ ◆ Denosumab ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Upadacitinib ◆ ◆ ◆    ◆ ◆ ◆ Dexamfetamine ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Lipid Lowering Agents Dextromethorphan ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Alirocumab ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Disulfiram ◆ ◆ ◆   ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Atorvastatin ◆ ◆ ◆ ◆ ◆ ◆  ◆ ◆ Donepezil Dorzolamide ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Bezafibrate ◆ ◆ ◆ ◆ ◆ ◆  ◆  Dupilumab ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Evolocumab ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Eliglustat ◆ ◆ ◆ ◆  ◆ ◆ ◆ ◆ Ezetimibe ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Emicizumab ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Fenofibrate ◆ ◆ ◆ ◆ ◆ ◆  ◆ ◆ Epoetin alfa ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Fish oils ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Etelcalcetide ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Fluvastatin ◆ ◆ ◆ ◆ ◆ ◆  ◆ ◆ Febuxostat ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Gemfibrozil ◆ ◆ ◆ ◆ ◆ ◆  ◆ ◆ Filgrastim ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Lovastatin ◆ ◆ ◆ ◆ ◆ ◆  ◆ ◆ Flibanserin ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Pitavastatin ◆ ◆ ◆ ◆ ◆ ◆  ◆ ◆ Gadopentetate (gadolinium) ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Pravastatin ◆ ◆ ◆ ◆ ◆ ◆  ◆ ◆ Glycerol phenylbutyrate ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Rosuvastatin ◆ ◆ ◆ ◆ ◆ ◆  ◆ ◆ Goserelin ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Simvastatin ◆ ◆ ◆ ◆ ◆ ◆  ◆ ◆ Influenza vaccine ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Interferon beta ◆ ◆ ◆ ⚫ ⚫  ◆ ◆ ◆

charts reflect the more cautious option.

www.hep-druginteractions.org

Interactions with HBV Treatment

Charts revised September 2021. Full information available at www.hep-druginteractions.org Page 7 of 6 Please note that if a drug is not listed it cannot automatically be assumed it is safe to coadminister. ADV, Adefovir; ETV, Entecavir; LAM, Lamivudine; PEG IFN, Peginterferon; RBV, Ribavirin; TBV, Telbivudine; TAF, Tenofovir alafenamide; TDF, Tenofovir-DF.

ADV ETV LAM PEG PEG RBV TBV TAF TDF ADV ETV LAM PEG PEG RBV TBV TAF TDF IFN IFN IFN IFN alfa-2a alfa-2b alfa-2a alfa-2b Other Drugs Continued Oxytocics Isosorbide mononitrate ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Ergometrine (ergonovine) ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Isotretinoin ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Mifepristone ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Lanreotide ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Misoprostol ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Levothyroxine ◆ ◆ ◆ ◆ ◆  ◆ ◆ ◆ Parkinsonism Agents Lofexidine ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Benztropine ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Lumacaftor/Ivacaftor ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Carbidopa ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Magnesium ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆

Orphenadrine ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Melatonin ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Memantine ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Pramipexole ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Methylphenidate ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Procyclidine ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Minoxidil ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Rasagiline ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Modafinil ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Ropinirole ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Naftidrofuryl ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ PBC Agents

Nalmefene ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Obeticholic acid ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ for distribution. for Naloxone ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Ursodeoxycholic acid ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Naltrexone ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Steroids ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Neostigmine Beclometasone ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Nicorandil ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Betamethasone ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Nusinersen ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Budesonide ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Ocrelizumab ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Orlistat ◆ ◆ Ciclesonide ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Penicillamine ◆ ◆ ◆ ◆ ◆ ◆  ◆  Clobetasol (topical) ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Pentoxifylline ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Clobetasone (topical) ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Phenylephrine ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Dexamethasone ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Pilocarpine ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Fludrocortisone ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Piracetam ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Flunisolide ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Potassium ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Fluticasone ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Protamine sulphate ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Hydrocortisone (topical) ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Pseudoephedrine ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Methylprednisolone ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Pyridostigmine ◆ ◆ ◆ ◆ ◆ Mometasone ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Raloxifene ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Prednicarbate ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Sevelamer ◆ ◆ Prednisone ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Strontium ranelate ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Thalidomide ◆ ◆ ◆    ◆ ◆ ◆ Triamcinolone ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Tranexamic acid ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Urological Agents Varenicline ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Alfuzosin ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Desmopressin ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Dutasteride ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Finasteride ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Mirabegron ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Silodosin ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Solifenacin ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Tamsulosin ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ Tolterodine ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆ ◆

charts reflect the more cautious option.