Table S11. Up or down regulated genes in Tcof1 over-expressed neuroblastoma N1E-115 cells involved in different KEGG pathways analysed by DAVID database List Pop Pop Fold Term P Value Genes Bonferroni Benjamini FDR Total Hits Total Enrichment
MAD1L1, DBF4, CDC16, GM8416, CCNE2, CCNE1, CDC45, CDKN2A, MCM7,
CDKN2C, GM5593, CCNA2, CUL1, STAG1, ANAPC1, CDC7, CDK1, ANAPC2, mmu04110:Cell cycle 1.10E-12 CDC6, CCNH, MCM2, CDK7, MCM3, CDK4, MCM4, CDK2, MCM5, MCM6, 635 128 5738 3.176796 1.99E-10 1.99E-10 1.35E-09
CCND1, MAD2L1, BUB1B, LOC100045442, ANAPC7, LOC100048076, FZR1,
LOC
ODC1, GM9115, GCLC, G6PDX, GSTM6, GSTM5, HNRPLL, GSTM7, GSTM1, mmu00480:Glutathione 9.29E-05 MGST3, GSTM2, GPX1, GSTM4, GPX4, GM7993, GPX3, IDH2, GM6742, SMS, 635 52 5738 2.954149 0.016673 0.008371 0.114458 metabolism GM14680, G6PD2, MGST1
LOC100048076, APC2, GRB2, FOS, CASP3, CASP9, LOC100047927, AKT3, mmu05210:Colorectal cancer 1.12E-04 AXIN1, EGFR, MSH6, CYCS, SMAD4, LEF1, BIRC5, BAD, MAPK10, APPL1, 635 86 5738 2.416664 0.020005 0.006713 0.137555
DVL1, MAPK1, CCND1, BAX, GSK3B, MAPK3, ARAF
ANAPC1, CDK1, ANAPC2, FZR1, HSP90AA1, GNAI2, MAPK10, CDC16, mmu04914:Progesterone-mediate 2.69E-04 GM8416, CDC25C, CDC25A, CDK2, CDC25B, CCNB1, MAPK1, MAD2L1, 635 85 5738 2.338786 0.047571 0.012111 0.331442 d oocyte maturation MAPK14, ARAF, MAPK3, BUB1, GM5593, ANAPC7, CCNA2, AKT3
GM2A, AP1G1, LGMN, HEXB, ACP2, CLTC, ASAH1, ATP6V0B, GLB1, mmu04142:Lysosome 4.40E-04 LAPTM5, AP3M1, GBA, LAPTM4B, CLN3, CTSZ, LAPTM4A, AP4S1, FUCA1, 635 119 5738 2.050235 0.076622 0.015817 0.54152
MANBA, DNASE2B, GLA, ARSA, GAA, AP4B1, GGA2, ATP6V0A2, CLN5
EGFR, HSP90AA1, GRB2, CREB1, LEF1, BAD, CDK2, HRAS1, CCNE2, MAPK1, mmu05215:Prostate cancer 6.18E-04 CCNE1, CCND1, CDKN1A, CASP9, GSK3B, ARAF, MAPK3, IKBKG, CREB3L3, 635 90 5738 2.208854 0.105801 0.018465 0.758817
IKBKB, AKT3, CHUK
CDK1, LOC640611, CYCS, CHEK1, ATR, CDK4, GM8416, CCNG2, CDK2, mmu04115:p53 signaling pathway 0.001047 635 69 5738 2.357275 0.172721 0.026724 1.283249 GTSE1, CCNE2, CCNB1, CCNE1, CCND1, CASP3, CDKN1A, CDKN2A, CASP9, CD82, BAX, GM5593
LOC100048076, CTBP1, LOC640611, GRB2, LOC100045360, CBL, SMAD4, mmu05220:Chronic myeloid 0.001235 BAD, CDK4, LOC100048010, HRAS1, MAPK1, CCND1, CDKN1A, CDKN2A, 635 76 5738 2.259055 0.200471 0.027579 1.512412 leukemia HDAC1, ARAF, MAPK3, IKBKG, IKBKB, CRK, AKT3, CHUK
LOC100048010, CCNE2, CCNE1, CDC42, FOS, CASP3, CDKN2A, CASP9, FGF1,
CHUK, AKT3, EGFR, CTBP1, HSP90AA1, CYCS, LEF1, CDK4, DAPK3, CDK2, mmu05200:Pathways in cancer 0.001712 635 323 5738 1.510699 0.266715 0.033882 2.090914 HRAS1, MAPK1, CCND1, MAPK3, LAMC2, LOC100048076, CKS1B, APC2,
GRB2, LOC640611, EGLN3, ITGB1, ITGAV, LOC100047927, FN1, AX
CKS1B, FHIT, LOC640611, CYCS, ITGA3, CDK4, ITGB1, CDK2, CCNE2, mmu05222:Small cell lung cancer 0.001902 CCNE1, CCND1, LAMA4, ITGA6, CASP9, ITGAV, IKBKG, LAMC2, IKBKB, 635 85 5738 2.12617 0.291487 0.033872 2.319833
AKT3, CHUK, FN1
LOC100044385, AURKA, CDC16, GM8416, CCNE2, CCNE1, PPP2CB, BUB1,
CAMK2D, GM5593, CAMK2B, FBXW11, CUL1, ANAPC1, CDK1, ANAPC2, mmu04114:Oocyte meiosis 0.003178 635 115 5738 1.88582 0.43795 0.05103 3.848553 CDC20, CDC25C, ITPR3, ITPR1, CDK2, CCNB1, MAPK1, MAD2L1, MAPK3,
CALM3, ANAPC7, CALM1
EGFR, APC2, GRB2, LEF1, BAD, HRAS1, MAPK1, CCND1, CASP9, GSK3B, mmu05213:Endometrial cancer 0.003459 635 52 5738 2.432829 0.465909 0.050923 4.18215 MAPK3, LOC100047927, ARAF, AKT3, AXIN1
EGFR, LOC100048076, LOC640611, SMAD4, BRCA2, MAPK10, BAD, CDK4, mmu05212:Pancreatic cancer 0.004489 CDC42, MAPK1, CCND1, CDKN2A, CASP9, MAPK3, IKBKG, ARAF, IKBKB, 635 72 5738 2.133552 0.557074 0.060721 5.395945
AKT3, CHUK mmu00511:Other glycan 0.005375 MAN2B2, HEXB, FUCA2, FUCA1, MANBA, GLB1, GBA 635 16 5738 3.953346 0.62297 0.067302 6.42826 degradation
LOC100048076, BMP4, BMP2, ACVRL1, FST, SMAD4, LOC100044385, INHBA, mmu04350:TGF-beta signaling 0.005945 MAPK1, ACVR2A, ACVR2B, ID2, ID1, MAPK3, PPP2CB, ID3, BMP7, BMP5, 635 87 5738 1.973427 0.660173 0.069427 7.08807 pathway CUL1, BMPR1A, ACVR1 mmu04012:ErbB signaling 0.005945 EGFR, ERBB3, GRB2, CBL, MAPK10, BAD, LOC100048010, HRAS1, NCK2, 635 87 5738 1.973427 0.660173 0.069427 7.08807 pathway MAPK1, EIF4EBP1, CDKN1A, GSK3B, MAPK3, ARAF, CAMK2D,
LOC100044475, CAMK2B, CRK, MAP2K7, AKT3
CYP2C55, CYP3A13, ADH5, CYP2B10, GSTM6, GSTM5, ALDH3B1, GSTM7, mmu00982:Drug metabolism 0.006813 635 75 5738 2.04821 0.70988 0.074426 8.083541 MGST3, GSTM1, GSTM2, GSTM4, FMO2, FMO3, CYP2A5, MGST1, CYP2A4 mmu00520:Amino sugar and CYB5R3, GMPPB, GALK1, CYB5R1, GNPDA1, MPI, GNPDA2, GNPNAT1, 0.006939 635 44 5738 2.464424 0.716427 0.071453 8.226324 nucleotide sugar metabolism HEXB, GALT, GALE, GPI1 mmu00052:Galactose metabolism 0.006975 GALK1, AKR1B7, B4GALT2, GLA, AKR1B3, GAA, GALT, GALE, GLB1 635 27 5738 3.012073 0.718317 0.067967 8.268127 mmu00270:Cysteine and DNMT3A, AHCY, AMD-PS3, MAT2A, GOT2, DNMT1, AHCYL1, ENOPH1, 0.007784 635 33 5738 2.738249 0.756926 0.071738 9.184639 methionine metabolism AMD1, SMS, GM14680, DNMT3B, AMD2
GM13646, HIST1H2BP, HIST1H2BM, HIST1H2BN, H2AFV, HIST1H2BL, mmu05322:Systemic lupus HIST1H2BJ, H2AFZ, H2AFX, ACTN1, H2-DMB1, LOC100045490, H2AFJ, 0.008054 635 103 5738 1.842336 0.768612 0.070569 9.488885 erythematosus H2-DMB2, C8A, H2-OA, HIST1H2AB, HIST1H2AC, HIST1H2AG, HIST1H2AD,
HIST1H2AE, HIST2H3C1, GM11277, C1S, GM11276, IGH-VJ558, IGH, HIST2H3
ACADVL, ACAA2, ACOX1, ALDH7A1, ADH5, ACADL, ACSL4, HADH, mmu00071:Fatty acid metabolism 0.008293 635 45 5738 2.409659 0.778501 0.069262 9.757781 ACAA1A, ACAA1B, HADHA, ALDH9A1 mmu00280:Valine, leucine and BCKDHA, ACAA2, ALDH6A1, ALDH7A1, MCCC1, MCEE, HADH, ACAA1A, 0.009844 635 46 5738 2.357275 0.833145 0.078168 11.48247 isoleucine degradation ACAA1B, HADHA, ALDH9A1, AUH mmu05223:Non-small cell lung EGFR, FHIT, GRB2, LOC640611, BAD, CDK4, HRAS1, MAPK1, CCND1, 0.013022 635 54 5738 2.175386 0.906751 0.09801 14.92209 cancer CDKN2A, CASP9, MAPK3, ARAF, AKT3 mmu00740:Riboflavin metabolism 0.018939 ENPP1, ENPP3, ACP2, FLAD1, ACP1, ACPP 635 15 5738 3.614488 0.968595 0.134285 21.00082 mmu05221:Acute myeloid GRB2, LEF1, BAD, HRAS1, MAPK1, EIF4EBP1, CCND1, MAPK3, IKBKG, 0.019772 635 57 5738 2.060892 0.97307 0.134615 21.82368 leukemia ARAF, IKBKB, AKT3, CHUK
EGFR, LOC640611, GRB2, CDK4, HRAS1, MAPK1, CCND1, CDKN1A, mmu05214:Glioma 0.02079 635 64 5738 1.976673 0.977689 0.136064 22.81924 CDKN2A, MAPK3, ARAF, CAMK2D, CALM3, CAMK2B, AKT3, CALM1 mmu00630:Glyoxylate and 0.025104 GLYCTK, HAO1, ACO2, GRHPR, MDH2, HYI 635 16 5738 3.388583 0.989967 0.156706 26.90852 dicarboxylate metabolism mmu00980:Metabolism of CYP2C55, CYP3A13, ADH5, EPHX1, CYP2B10, GSTM6, GSTM5, ALDH3B1, 0.026376 635 66 5738 1.916774 0.992079 0.158689 28.07587 xenobiotics by cytochrome P450 GSTM7, MGST3, GSTM1, GSTM2, GSTM4, MGST1
GRB2, MAGED1, CDC42, MAP3K5, MAP3K3, CAMK2D, SH2B3, CAMK2B, mmu04722:Neurotrophin 0.026622 CSK, MAP2K7, AKT3, IRAK1, BAD, MAPK10, HRAS1, MAPK1, BAX, MAPK14, 635 130 5738 1.598716 0.992432 0.154991 28.29894 signaling pathway GSK3B, MAPK3, CALM3, IKBKB, LOC100047863, CRK, CALM1
CNOT8, EXOSC9, EXOSC7, EXOSC4, PNPT1, EXOSC2, DIS3, LOC100044383, mmu03018:RNA degradation 0.028836 635 60 5738 1.957848 0.994988 0.161828 30.28378 LSM5, ENO2, LSM3, HSPD1, LSM2, ENO1
HAGH, AKR1B7, ALDH7A1, ME2, AKR1B3, ACYP1, GLO1, GRHPR, mmu00620:Pyruvate metabolism 0.031858 635 41 5738 2.203956 0.997149 0.172242 32.91169 ALDH9A1, MDH2 mmu03030:DNA replication 0.03361 DNA2, MCM7, LIG1, MCM2, MCM3, MCM4, FEN1, MCM5, MCM6 635 35 5738 2.3236 0.997946 0.175826 34.39338 mmu00785:Lipoic acid 0.033887 LIAS, LIPT2, LOC100044878, LIPT1 635 3 5738 9.03622 0.99805 0.172287 34.62526 metabolism
EGFR, MAPK1, CDKN1A, CCND1, CDKN2A, LOC640611, MAPK3, ARAF, mmu05219:Bladder cancer 0.036729 635 42 5738 2.151481 0.998856 0.180622 36.95705 CDK4, DAPK3, HRAS1
IGH, LIMK2, LYN, GM5637, ASAP1, ARPC5, CDC42, ARPC1B, MAPK1, mmu04666:Fc gamma R-mediated 0.038635 DOCK2, GSN, ARPC2, LOC676654, MAPK3, CRK, AKT3, IGH-VJ558, DNM1, 635 98 5738 1.659714 0.999201 0.184344 38.47807 phagocytosis DNM2 mmu00030:Pentose phosphate 0.059688 ALDOA, ALDOC, G6PDX, GM5081, FBP2, GPI1, G6PD2, PRPS1 635 26 5738 2.432829 0.999985 0.266134 53.17558 pathway mmu01040:Biosynthesis of 0.069889 ACOT9, ACOX1, ELOVL5, ELOVL6, ACAA1A, ACAA1B, HADHA 635 27 5738 2.342724 0.999998 0.298422 59.06734 unsaturated fatty acids
ENAH, APC2, GM5637, ITGB4, ITGB5, BDKRB2, ARPC5, ITGB1, IQGAP1, mmu04810:Regulation of actin CDC42, GSN, ARPC2, ITGAV, MSN, FGF1, CSK, FN1, EGFR, GIT1, LIMK2, 0.078398 635 217 5738 1.33253 1 0.322181 63.4525 cytoskeleton BAIAP2, ACTN1, ITGA3, HRAS1, ARPC1B, MAPK1, ITGA6, MAPK3, ARAF,
CYFIP2, CRK, DIAP3 mmu05218:Melanoma 0.087148 EGFR, LOC640611, HGF, BAD, CDK4, HRAS1, MAPK1, CDKN1A, CCND1, 635 71 5738 1.654519 1 0.345035 67.50749 CDKN2A, MAPK3, ARAF, FGF1, AKT3 mmu04320:Dorso-ventral axis 0.08733 EGFR, MAPK1, ETS1, GRB2, MAPK3, ETV6 635 22 5738 2.464424 1 0.338667 67.5874 formation
GNAO1, GNAI2, LYN, LOC100044385, ITPR3, ITPR1, HRAS1, CRHR1, MAPK1, mmu04730:Long-term depression 0.094644 635 72 5738 1.63154 1 0.355278 70.64853 LOC676654, MAPK3, PPP2CB, ARAF, GUCY1A3 mmu04662:B cell receptor IGH, LYN, GRB2, HRAS1, FOS, MAPK1, LOC676654, GSK3B, MAPK3, IKBKG, 0.098506 635 80 5738 1.581339 1 0.360396 72.1553 signaling pathway CD81, IKBKB, AKT3, CHUK, IGH-VJ558