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bcltofastq tool (Illumina, San Diego, the by scale invariant feature CA), producing a FASTQ format. transform (SIFT), Polymorphism DNA Isolation and Sequencing The resulting reads (in FastQ) were Phenotyping (PolyPhen), Grantham

aligned to the hg19 reference genome5 score, MutationTaster, Align GVGD, with Burrows-Wheeler Aligner. and PhyloP. Variants were further Genomic DNA was isolated Sambamba was used for processing included when they were absent according to standard procedures the aligned reads, and then, we or had a minor allele frequency of–

and measured for quantity applied Genome Analysis Tool Kit <0.02 in the public databases of10 100014 and quality by using a 2200 duplicate removal and performed Genomes, ESP6500, or dbSNP. TapeStation (Agilent, Santa Clara, single polymorphism and Next, variants were filtered according CA). DNA from the patient was - discovery and to patient-specific HPO terms

sheared by using a S220 Focused- genotyping using standard hard- provided by21 the consulting clinical ultrasonicator (Covaris, Woburn, filtering parameters according– to geneticists. MA). Libraries were prepared by the Genome Analysis Tool Kit Best 6 8 Synonymous variants and intronic using NEBNext DNA Library Prep Practices recommendations. In variants were excluded except for Master Mix Set for Illumina (New this last processing step, we applied those within 5 bp of splice sites. England Biolabs, Ipswich, MA). In exome-based variant filtering Heterozygous variants without short, DNA fragments were end- using an exome BED file (based a compound variant in the same repaired followed by dA-Tailing and on Ensembl GRCh37.75, including were filtered with a cutoff adaptor ligation. Size selection was 20 bp -flanking regions) and of minor allele frequency <0.005 performed by using the LabChip supplemented with exon information in the databases used to identify XT (PerkinElmer, Waltham, MA), from included in the Agilent dominant variants. Homozygous and after which 5 cycles of Polymerase V5 and SureSelect Inherited Diseases compound heterozygous variants chain reaction amplification was capturing kits as well as from the 2,​9 were not further filtered on the performed. Libraries were measured disease gene list from the CGD. basis of minor allele frequency. We by using the LabChip GX and diluted used MOLGENIS software to further to a final concentration of 9 pmol/L. Sequence variants were filtered by – annotate the resulting candidate Libraries were then sequenced on using Cartagenia Next-Generation variants with Combined Annotation- 2 flow cells on a HiSeq 2500 high- Sequencing Bench Laboratory Dependent Depletion (CADD) scores, throughput instrument (Illumina, San software (Cartagenia, Agilent, × Online Inheritance in Man –(OMIM) Diego, CA) set to rapid-run modus Santa Clara, CA) with an automated – , and reported modes of by using 2 100 bp paired-end filtering tree. We excluded variants 15 19 inheritance of the genes. When sequencing (patients 1401 1512) with a read depth <5 and those the observed zygosity state matched or on a NextSeq 500 (Illumina, San classified as benign or likely × the inheritance mode of the genes, Diego, CA) on 1 high-output flow benign in an in-house generated – we manually evaluated variants for by using 2 150 bp paired-end database. Variants in this database matching with the patient sequencing (patients 1517 1605). are classified according to our in a multidisciplinary team of at least standardized clinical classification, the operating technician, a clinical Data Analysis taking into account minor allele geneticist, and a laboratory specialist. frequencies from different databases (the 1000 Genomes project, Exome Annotation and visualization To generate variant call format Sequencing Project 6500 [ESP6500] software, Cartagenia (Agilent, (VCF) files that serve as input for the Exome Aggregation Consortium Santa Clara, CA), MOLGENIS, and variant selection and interpretation, [ExAC], Genome of the Netherlands Alamut (Interactive Biosoftware, the sequencing data were processed [GoNL], or the database of single Rouen, France) were used to classify as follows: binary base call files nucleotide polymorphisms [dbSNP]) according to standard from the sequencer were converted and using Alamut software for guidelines developed by the UMCG to human readable format with the predicted effects of the variants on genetics department for reporting PEDIATRICS Volume 140, number 4, October 2017 1

van Diemen et al https://doi.org/10.1542/peds.2016-2854 October 2017 Rapid Targeted Genomics in Critically Ill Newborns 4 140 Pediatrics 2017 ROUGH GALLEY PROOF diagnostic results to clinicians and a procedure for preimplantation on genes mapping to homozygous

based on international guidelines16,​17,​20 as genetic diagnosis was started for regions identified from a single described by Richards et al. future pregnancies. nucleotide polymorphism array.KLHL41 We Patient 1502 identified a homozygous c.1213G>A, p.Gly405Ser in , Results a gene known to be associated with autosomal recessive nemaline A female child was born at term 23 myopathy. The p.Gly405Ser to nonconsanguineous Dutch − mutation has not been reported Detailed Overview of Patients With parents with a birth weight of 1975 before. Intensive treatment was a Genetic Diagnosis After Rapid g ( 4 SD). She presented with a withdrawn because no curative noncompaction cardiomyopathy, a WGS options were available. The parents wide-open ductus arteriosus, and did not agree to an autopsy. several apical ventricular septal They were counseled as having a defects at the age of 2 weeks and Patient 1407 25%-recurrence risk for nemaline developed an atrioventricular block. myopathy, and reproductive options She died of heart failure at the age were discussed to avoid the birth of of 4 weeks despite having a clipped An 11-month old boy born to another affected child. ductus arteriosus and an implanted nonconsanguineous Dutch parents pacemaker. Noncompaction Patient 1508 presented with developmental delay, cardiomyopathy was confirmed microcephaly, progressive seizures, “ ” by autopsy. Targeted genomics and West syndrome. He also suffered using cardiomyopathy (HP:​ A female infant was born to from severe visual impairment. A 0001638) for filtering did not result nonconsanguineous Dutch MRI showed agenesis of the in any candidate single nucleotide parents. She was admitted to the corpus callosum with a horizontal variants. A de novo microdeletion hospital at age 5 months because fissure, colpocephaly, delayed of 1p36.33p36.32 was detected by of microcephaly, developmental myelination, vermis hypoplasia, and single nucleotide polymorphism delay, and a presumed progressive an abnormal configuration of the array as well as by our in-house movement disorder. She had a brainstem. A ventricular septal defect “ copy number variant analysis tool bilateral hip dysplasia. The first was also present. We filtered variants ” “ "Copy Number Variation Detection filtering of the data for global in the CGD-based selection of genes “ ” ” In Next-generation sequencing Gene developmental delay (HP:001263),​ for abnormality of the nervous “ ” panel" (CoNVaDING), used on the postnatal microcephaly (HPO system (HP:000707).​ We identified 30 EPG5 WGS data. Cardiomyopathy is a 005484), and/or dystonia (HP:​ a missense and a splice-site mutation ∼ known abnormality associated with 001332) did not produce any suitable in the gene, c.7475T>G, 1p36 deletion syndrome in 27% candidate variants. p.Phe2492Cys and c.5869+1G>A, a 31 ’ of patients. The parents were gene known to be associated with Follow-up on the patient 1 week 22 counseled as having a low recurrence Vici syndrome. Although the child s later (age 5.5 months) revealed risk. clinical picture was not initially severe sensorineural deafness, recognized as Vici syndrome, at his Patient 1506 with thresholds of 85 dB at 3 kHz, last follow-up at the age of 2.5 years, and the data were reanalyzed by “ ” he did show Vici features, including using the additional HPO term intractable seizures and severe A girl was born to consanguineous hearing impairment (HPO psychomotor retardation (epileptic parents (first cousins) of Somalian 000365), resulting in the detection of encephalopathy, severe feeding origin. She presented with fetal compound heterozygous mutations problems [Percutaneous endoscopic akinesia syndrome with flexion RMND1c.1262_1275del, p.Asn421Thrfs*18RMND1 gastrostomy tube fed], elevated contractures and hip dislocation at and c.713A>G, p.Asn238Ser in liver [possible toxic effect the age of 4 days. A muscle biopsy . Mutations in the of antiepileptics], urethral valves, was suggestive for a congenital gene are known to be associated recurrent urinary tract infections, (nemaline) myopathy. In the data with the autosomal recessive “ ” and bladder dysfunction), and analysis, filtering initially for mitochondrial disease known as severe psychomotor retardation. A myopathy (HP:0003198)​ resulted combined oxidative “ no-resuscitation policy was instated in no candidates. Subsequent, deficiency-11. The ” 24,​25 at diagnosis. His parents were broader filtering for abnormality of has been reported before,​ counseled for a 25%-recurrence risk, the musculature (HP:0003011)​ and whereas the 2 van Diemen et al

van Diemen et al https://doi.org/10.1542/peds.2016-2854 October 2017 Rapid Targeted Genomics in Critically Ill Newborns 4 140 Pediatrics 2017 ROUGH GALLEY PROOF Article

has not been reported earlier. At for the missense mutation. Although of vanishing white matter. Both the age of 15 months, her motor this particular mutation has not been mutations have been reported before

development was consistent with reported before, another mutation in the Human27,​28 Genome Mutation an age of 8 months, whereas her of the same position was Database. Because no treatment communicative development was reported in the options were available, intensive at the level for of 5 months of age. Mutation Database (c.518G>A life support was withdrawn. A cochlear device was implanted. [p.R194H]). The girl died at the age Transportation to a hospital with She has developed a chronic of 4 weeks from respiratory failure. specific expertise on this disease RMND1renal insufficiency and is fed by The parents were counseled as had been arranged to safeguard a percutaneous gastric tube. The having a 25%-recurrence risk, and postmortem investigations, but c.1262_1275del mutation was offered for our rapid diagnosis meant this was maternal, but the c.713A>G future pregnancies. Preconception could be canceled. The parents mutation was not detected in the genetic screening was requested by were counseled as having a father. Nonpaternity was confirmed the parents but revealed no further 25%-recurrence risk for vanishing by standard testing, and this couple shared, disease-related variants in white matter disease, and their

was counseled as having a low 70 genes associated with severe32 reproductive options to avoid the recurrence risk. autosomal recessive diseases. birth of another affected child were Patient 1519 Patient 1601 discussed. Patient 1605

A newborn girl was the second A 7-month old boy was the first child child of consanguineous Dutch of nonconsanguineous Dutch parents A 3-month old girl born to a parents (their grandfathers were and was born after intrauterine consanguineous couple (first cousins) monozygotic twins). She suffered insemination. His psychomotor of Syrian origin presented with from metabolic acidosis with development had been a little slow, rapidly deteriorating heart failure persistently elevated serum lactate and the parents had noticed that his and hepatomegaly. She had 3 healthy “ ” (up to 14.6 mmol/L), which could not muscle strength had diminished in siblings. Targeted genomics using “ “ ” just be caused by perinatal asphyxia. the 2 months before his admittance. cardiomyopathy (HP:001638)​ and/ ” After filtering for abnormality of After a gastrointestinal infection, or hepatomegaly (HP:002240)​ “ /homeostasis (HP:​ he had deteriorated rapidly and for filtering revealed a homozygous ” GLB1 0001939) and/or abnormal was admitted to the hospital in a mutation c.176G>A p.R59H in respiratory system morphology coma. An MRI showed severe white , consistent with a diagnosis (HP:0012252)​ and focusing on matter anomalies, and a diagnosis of early-onset GM1 gangliosidosis. homozygous regions identified in of vanishing white matter was pR59H is a mutation commonly a single nucleotide polymorphism considered. Because of the genetic found in GM1 gangliosidosis and is array, we detected a homozygous heterogeneity of this disease, we associated with negligible GFER “ ” 29 missense mutation c.580C>T performed rapid WGS and filtered activity. No treatment options were “ (p.R194C) in , a gene known variants for leukoencephalopathy available, and she died shortly after ” to be associated with autosomal (HP:0002352)​ and/or abnormal the diagnosis was confirmed. The recessive, progressive, mitochondrial CNS myelination (HP:0004335).​ We parents were counseled as having myopathy with congenital cataract, detected compound heterozygousEIF2B5 a 25%-recurrence risk, and their hearing26 loss, and developmental mutations c.1015C>T (p.R339W) reproductive options to avoid the delay. Both parents and the healthy and c.1208C>T (p.A403V) in , birth of another affected child were elder brother were heterozygous consistent with the diagnosis discussed.

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van Diemen et al https://doi.org/10.1542/peds.2016-2854 October 2017 Rapid Targeted Genomics in Critically Ill Newborns 4 140 Pediatrics 2017 ROUGH GALLEY PROOF SUPPLEMENTAL TABLE 3 Overview of Genetic Tests Performed in Regular Diagnostics in a Prospective Study of Critically Ill Children ID M or F Age at Clinical Features Provisional Diagnosis Causal Gene and/or SNP Array Other Genetic Tests Presentation Variants From Rapid Diagnostics 1401 F 2 mo Lack of spontaneous No — Dup 2p11.1 Dystonia gene panel, movements, tremors, (centromeric) WES no swallowing 1402 F 4 mo Dilated cardiomyopathy No — No abnormalities mtDNA, WES 1405 F 1 d Intractable seizures, No — No abnormalities gene panel perinatal asphyxia 1406 M 10 d Intractable seizures, No — No abnormalities Epilepsy gene panel intracerebral hemorrhage 1407 M 11 mo Microcephaly, Vici syndrome EPG5 c.7475T>G No abnormalities WES: confirmation of vermis hypoplasia, (p.Phe2492Cys) and EPG5 c.7475T>G West syndrome, c.5869+1G>A (p.Phe2492Cys) and developmental delay, c.5869+1G>A VSD 1408 M 7 mo Prematurity (24+6 No — No array performed Single-gene mutation w), IVF pregnancy, analysis: NUBPL, TK2, cholestasis DGUOK, POLG, MPV17, C10ORF2; mtDNA 1501 F 5 wk Hydrocephaly, No — Comparative genomic — intraventricular hybridization array, hemorrhage no abnormalities 1502 F 2 wk IUGR, seizures, 1p36 microdeletion — 1p36.33p36.32 — cardiomyopathy, AV- syndrome (0–3 603 518) × 1 block, PDA, VSD 1504 F 9 d Intractable seizures, No — No abnormalities Epilepsy gene panel, dystonia WES, single-gene mutation analysis: DDC, TH 1505 M 10 d Prematurity (31+2 w), No — 9p21.3p21.2 Single-gene mutation coarctation of the (25 547 963– analysis: GPC3, aorta, VSD, sagittal 25 760 194) × 1 NOTCH1, CDKN1C craniosynostosis, bilateral postaxial polydactyly, cleft palate, eventration of diaphragm, hypospadias 1506 M 1 d Bilateral hip dislocation, Nemaline myopathy-9 KLHL41 c.1213G>A No abnormalities WES: confirmation of flexion contractures, p.(Gly405Ser) KLHL41 c.1213G>A supernumerary p.(Gly405Ser) nipple, cryptorchidism, consanguineous parents 1508 F 5 mo Microcephaly, dystonia, Combined oxidative RMND1 5p13.3 (33 047 048– Dystonia gene panel developmental delay, phosphorylation c.1262_1275del 33 664 785) × 3 deafness deficiency-11 (p.Asn421Thrfs*18) and c.713A>G (p.Asn238Ser) 1509 F 4 mo Pulmonary interstitial No — No abnormalities Single-gene mutation glycogenosis, analysis: SFTPB, consanguineous ABCA3 parents 1511 F 4 wk Prematurity (30 w), No — Xp21.1 (31 691 480– Homozygous deletion polyhydramnion, 31 870 763) × 1,​ analysis: SMN1, hypotonia, mother 19p13.3p13.2 DMPK; myopathy muscle weakness (6 891 801– gene panel 7 108 864) × 3

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TABLE 3 Continued ID M or F Age at Clinical Features Provisional Diagnosis Causal Gene and/or SNP Array Other Genetic Tests Presentation Variants From Rapid Diagnostics 1513 F 2 wk Hypotonia, cholestasis No — No abnormalities Liver and/or and (transient) cholestasis gene hyperinsulinism panel 1514 F 2 mo Bulbar weakness and/ No — No abnormalities — or palsy, abnormal muscle tone, central hypotonia, mixed hearing loss 1515 M 2 wk Cardiomyopathy No — No abnormalities Cardio gene panel: MYL2, NM_000432.3, he c.403-1G>C (MYL2, MY2_00A); TTN, NM_001267550.1 maternal, he c.86614G>A, p.(Asp28872Asn) 1519 F 5 d Persistent lactic Mitochondrial GFER c.580C>T 9p13.3 (33 574 863– — acidosis, dysmorphic progressive (p.Arg194Cys) 34 505 649) × 3 features myopathy 1601 M 9 mo Sudden seizures Leukoencephalopathy EIF2B5 c.1015C>T No abnormalities — with vanishing (p.Arg339Trp) white matter and c.1208C>T (p.Ala403Val) 1602 M 9 wk Growth delay, No — Xq27.1q27.2 gene cholestasis, (140 136 288– analysis; liver and/ ventricular septal 140 682 858) × 0, or cholestasis defects 9p24.3 (0–443 073) gene panel; WES; × 3 methylation analysis: LIT1, H19 1603 M 4 d IUGR, microcephaly, No — No abnormalities MLPA: MEPC2; epilepsy epilepsy, gene panel; single- encephalopathy, gene mutation contractures analysis: PNPO 1604 M 2 mo Abnormal muscle tone, No — No abnormalities Homozygous deletion feeding problems analysis: SMN1; mtDNA; single-gene mutation analysis: DMPK; methylation analysis: SNRPN; WES 1605 F 3 mo Cardiomyopathy, GM1 gangliosidosis GLB1 c.176G>A No abnormalities Cardio gene hepatomegaly, (p.Arg59His) panel, TBX20, consanguineous NM_001077653.2, parents (first he c.456C>G, cousins) p.(Ile152Met) AV, atrioventricular; F, female sex; ID, identification number; IUGR, intrauterine growth retardation; IVF, in vitro fertilization; M, male sex; MLPA, multiplex ligation-dependent probe amplification; mtDNA, mitochondrial DNA; PDA, persistent ductus arteriosus; SNP, single nucleotide polymorphism; VSD, ventricular septal defect; WES, whole-exome sequencing.— , not applicable.

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van Diemen et al https://doi.org/10.1542/peds.2016-2854 October 2017 Rapid Targeted Genomics in Critically Ill Newborns 4 140 Pediatrics 2017 ROUGH GALLEY PROOF SUPPLEMENTAL TABLE 4 A Full List of Genes Investigated: CGD-Based Gene Panel HGNC Gene Symbol HGNC:ID A2M HGNC:7 A4GALT HGNC:18149 AAAS HGNC:13666 AAGAB HGNC:25662 AARS2 HGNC:21022 AARS HGNC:20 AASS HGNC:17366 ABAT HGNC:23 ABCA12 HGNC:14637 ABCA1 HGNC:29 ABCA3 HGNC:33 ABCA4 HGNC:34 ABCA5 HGNC:35 ABCB11 HGNC:42 ABCB1 HGNC:40 ABCB4 HGNC:45 ABCB6 HGNC:47 ABCB7 HGNC:48 ABCC11 HGNC:14639 ABCC2 HGNC:53 ABCC6 HGNC:57 ABCC8 HGNC:59 ABCC9 HGNC:60 ABCD1 HGNC:61 ABCD3 HGNC:67 ABCD4 HGNC:68 ABCG2 HGNC:74 ABCG5 HGNC:13886 ABCG8 HGNC:13887 ABHD12 HGNC:15868 ABHD5 HGNC:21396 ABL1 HGNC:76 ABO HGNC:79 ACACA HGNC:84 ACAD8 HGNC:87 ACAD9 HGNC:21497 ACADL HGNC:88 ACADM HGNC:89 ACADSB HGNC:91 ACADS HGNC:90 ACADVL HGNC:92 ACAN HGNC:319 ACAT1 HGNC:93 ACAT2 HGNC:94 ACBD6 HGNC:23339

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TABLE 4 Continued HGNC Gene Symbol HGNC:ID ACD HGNC:25070 ACE HGNC:2707 ACHE HGNC:108 ACO2 HGNC:118 ACOX1 HGNC:119 ACP2 HGNC:123 ACP5 HGNC:124 ACSF3 HGNC:27288 ACSL4 HGNC:3571 ACTA1 HGNC:129 ACTA2 HGNC:130 ACTB HGNC:132 ACTC1 HGNC:143 ACTG1 HGNC:144 ACTG2 HGNC:145 ACTN1 HGNC:163 ACTN2 HGNC:164 ACTN4 HGNC:166 ACVR1 HGNC:171 ACVR2B HGNC:174 ACVRL1 HGNC:175 ACY1 HGNC:177 ADA HGNC:186 ADAM10 HGNC:188 ADAM17 HGNC:195 ADAM9 HGNC:216 ADAMTS10 HGNC:13201 ADAMTS13 HGNC:1366 ADAMTS17 HGNC:17109 ADAMTS18 HGNC:17110 ADAMTS2 HGNC:218 ADAMTSL2 HGNC:14631 ADAMTSL4 HGNC:19706 ADAR HGNC:225 ADCK3 HGNC:16812 ADCK4 HGNC:19041 ADCY1 HGNC:232 ADCY5 HGNC:236 ADCY6 HGNC:237 ADIPOQ HGNC:13633 ADK HGNC:257 ADNP HGNC:15766 ADRA2B HGNC:282 ADRA2C HGNC:283 ADRB1 HGNC:285

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article-authors endPage startPage article-title issue volume buildID journal-title copyright proof doi pub-date TABLE 4 Continued HGNC Gene Symbol HGNC:ID ADRB2 HGNC:286 ADSL HGNC:291 AFF2 HGNC:3776 AFF4 HGNC:17869 AFG3L2 HGNC:315 AFP HGNC:317 AGA HGNC:318 AGBL1 HGNC:26504 AGK HGNC:21869 AGL HGNC:321 AGO1 HGNC:3262 AGPAT2 HGNC:325 AGPS HGNC:327 AGRN HGNC:329 AGT HGNC:333 AGTR1 HGNC:336 AGTR2 HGNC:338 AGXT HGNC:341 AHCY HGNC:343 AHDC1 HGNC:25230 AHI1 HGNC:21575 AICDA HGNC:13203 AIFM1 HGNC:8768 AIMP1 HGNC:10648 AIP HGNC:358 AIPL1 HGNC:359 AIRE HGNC:360 AK1 HGNC:361 AK2 HGNC:362 AKAP9 HGNC:379 AKR1C2 HGNC:385 AKR1D1 HGNC:388 AKT1 HGNC:391 AKT2 HGNC:392 AKT3 HGNC:393 ALAD HGNC:395 ALAS2 HGNC:397 ALB HGNC:399 ALDH18A1 HGNC:9722 ALDH1A3 HGNC:409 ALDH2 HGNC:404 ALDH3A2 HGNC:403 ALDH4A1 HGNC:406 ALDH5A1 HGNC:408 ALDH6A1 HGNC:7179

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TABLE 4 Continued HGNC Gene Symbol HGNC:ID ALDH7A1 HGNC:877 ALDOA HGNC:414 ALDOB HGNC:417 ALG10 HGNC:23162 ALG11 HGNC:32456 ALG12 HGNC:19358 ALG13 HGNC:30881 ALG14 HGNC:28287 ALG1 HGNC:18294 ALG2 HGNC:23159 ALG3 HGNC:23056 ALG6 HGNC:23157 ALG8 HGNC:23161 ALG9 HGNC:15672 ALK HGNC:427 ALMS1 HGNC:428 ALOX12B HGNC:430 ALOX5 HGNC:435 ALOXE3 HGNC:13743 ALPL HGNC:438 ALS2CL HGNC:20605 ALS2 HGNC:443 ALX1 HGNC:1494 ALX3 HGNC:449 ALX4 HGNC:450 AMACR HGNC:451 AMBN HGNC:452 AMELX HGNC:461 AMER1 HGNC:26837 AMH HGNC:464 AMHR2 HGNC:465 AMN HGNC:14604 AMPD1 HGNC:468 AMPD2 HGNC:469 AMPD3 HGNC:470 AMT HGNC:473 ANG HGNC:483 ANGPTL3 HGNC:491 ANK1 HGNC:492 ANK2 HGNC:493 ANKH HGNC:15492 ANKRD11 HGNC:21316 ANKRD26 HGNC:29186 ANKS6 HGNC:26724 ANLN HGNC:14082

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article-authors endPage startPage article-title issue volume buildID journal-title copyright proof doi pub-date TABLE 4 Continued HGNC Gene Symbol HGNC:ID ANO10 HGNC:25519 ANO3 HGNC:14004 ANO5 HGNC:27337 ANO6 HGNC:25240 ANTXR1 HGNC:21014 ANTXR2 HGNC:21732 AP1S2 HGNC:560 AP1S3 HGNC:18971 AP3B1 HGNC:566 AP4B1 HGNC:572 AP4E1 HGNC:573 AP4M1 HGNC:574 AP4S1 HGNC:575 AP5Z1 HGNC:22197 APCDD1 HGNC:15718 APC HGNC:583 APOA1 HGNC:600 APOA2 HGNC:601 APOA5 HGNC:17288 APOB HGNC:603 APOC2 HGNC:609 APOC3 HGNC:610 APOE HGNC:613 APOL1 HGNC:618 APOPT1 HGNC:20492 APP HGNC:620 APPL1 HGNC:24035 APRT HGNC:626 APTX HGNC:15984 AQP1 HGNC:633 AQP2 HGNC:634 AQP3 HGNC:636 ARAF HGNC:646 ARFGEF2 HGNC:15853 ARG1 HGNC:663 ARHGAP26 HGNC:17073 ARHGAP31 HGNC:29216 ARHGDIA HGNC:678 ARHGEF10 HGNC:14103 ARHGEF12 HGNC:14193 ARHGEF6 HGNC:685 ARHGEF9 HGNC:14561 AR HGNC:644 ARID1A HGNC:11110 ARID1B HGNC:18040

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TABLE 4 Continued HGNC Gene Symbol HGNC:ID ARIH1 HGNC:689 ARL13B HGNC:25419 ARL14EP HGNC:26798 ARL2BP HGNC:17146 ARL6 HGNC:13210 ARL6IP1 HGNC:697 ARMC4 HGNC:25583 ARMC5 HGNC:25781 ARNT2 HGNC:16876 ARSA HGNC:713 ARSB HGNC:714 ARSE HGNC:719 ART4 HGNC:726 ARVCF HGNC:728 ARX HGNC:18060 ASAH1 HGNC:735 ASCC1 HGNC:24268 ASCC3 HGNC:18697 ASCL1 HGNC:738 ASH1L HGNC:19088 ASIP HGNC:745 ASL HGNC:746 ASNS HGNC:753 ASPA HGNC:756 ASPH HGNC:757 ASPM HGNC:19048 ASPSCR1 HGNC:13825 ASS1 HGNC:758 ASXL1 HGNC:18318 ASXL3 HGNC:29357 ATCAY HGNC:779 ATF6 HGNC:791 ATIC HGNC:794 ATL1 HGNC:11231 ATL3 HGNC:24526 ATM HGNC:795 ATN1 HGNC:3033 ATOH7 HGNC:13907 ATP13A2 HGNC:30213 ATP1A2 HGNC:800 ATP1A3 HGNC:801 ATP2A1 HGNC:811 ATP2A2 HGNC:812 ATP2B3 HGNC:816 ATP2C1 HGNC:13211

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article-authors endPage startPage article-title issue volume buildID journal-title copyright proof doi pub-date TABLE 4 Continued HGNC Gene Symbol HGNC:ID ATP5A1 HGNC:823 ATP5E HGNC:838 ATP6AP2 HGNC:18305 ATP6V0A2 HGNC:18481 ATP6V0A4 HGNC:866 ATP6V1B1 HGNC:853 ATP6V1B2 HGNC:854 ATP7A HGNC:869 ATP7B HGNC:870 ATP8B1 HGNC:3706 ATPAF2 HGNC:18802 ATR HGNC:882 ATRX HGNC:886 ATXN10 HGNC:10549 ATXN1 HGNC:10548 ATXN2 HGNC:10555 ATXN3 HGNC:7106 ATXN7 HGNC:10560 ATXN8OS HGNC:10561 AUH HGNC:890 AURKC HGNC:11391 AUTS2 HGNC:14262 AVP HGNC:894 AVPR2 HGNC:897 AXIN1 HGNC:903 AXIN2 HGNC:904 B2M HGNC:914 B3GALNT1 HGNC:918 B3GALNT2 HGNC:28596 B3GALT6 HGNC:17978 B3GALTL HGNC:20207 B3GAT3 HGNC:923 B3GNT1 HGNC:15685 B4GALT1 HGNC:924 B4GALT7 HGNC:930 B9D1 HGNC:24123 B9D2 HGNC:28636 BAAT HGNC:932 BAG3 HGNC:939 BANF1 HGNC:17397 BAP1 HGNC:950 BARD1 HGNC:952 BBIP1 HGNC:28093 BBS10 HGNC:26291 BBS12 HGNC:26648

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TABLE 4 Continued HGNC Gene Symbol HGNC:ID BBS1 HGNC:966 BBS2 HGNC:967 BBS4 HGNC:969 BBS5 HGNC:970 BBS7 HGNC:18758 BBS9 HGNC:30000 BCAM HGNC:6722 BCAP31 HGNC:16695 BCHE HGNC:983 BCKDHA HGNC:986 BCKDHB HGNC:987 BCKDK HGNC:16902 BCL10 HGNC:989 BCL11A HGNC:13221 BCL2 HGNC:990 BCMO1 HGNC:13815 BCOR HGNC:20893 BCR HGNC:1014 BCS1L HGNC:1020 BDNF HGNC:1033 BEAN1 HGNC:24160 BEST1 HGNC:12703 BFSP1 HGNC:1040 BFSP2 HGNC:1041 BHLHA9 HGNC:35126 BHLHE41 HGNC:16617 BICC1 HGNC:19351 BIN1 HGNC:1052 BLK HGNC:1057 BLM HGNC:1058 BLNK HGNC:14211 BLOC1S3 HGNC:20914 BLOC1S6 HGNC:8549 BLVRA HGNC:1062 BMP15 HGNC:1068 BMP1 HGNC:1067 BMP2 HGNC:1069 BMP4 HGNC:1071 BMPER HGNC:24154 BMPR1A HGNC:1076 BMPR1B HGNC:1077 BMPR2 HGNC:1078 BMS1 HGNC:23505 BOLA3 HGNC:24415 BPGM HGNC:1093

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article-authors endPage startPage article-title issue volume buildID journal-title copyright proof doi pub-date TABLE 4 Continued HGNC Gene Symbol HGNC:ID BRAF HGNC:1097 BRAT1 HGNC:21701 BRCA1 HGNC:1100 BRCA2 HGNC:1101 BRF1 HGNC:11551 BRIP1 HGNC:20473 BRWD3 HGNC:17342 BSCL2 HGNC:15832 BSG HGNC:1116 BSND HGNC:16512 BTD HGNC:1122 BTK HGNC:1133 BUB1B HGNC:1149 C10 or F11 HGNC:23405 C10 or F2 HGNC:1160 C11 or F83 HGNC:34399 C12 or F57 HGNC:29521 C12 or F65 HGNC:26784 C15 or F41 HGNC:26929 C19 or F12 HGNC:25443 C1GALT1C1 HGNC:24338 C1QA HGNC:1241 C1QB HGNC:1242 C1QC HGNC:1245 C1QTNF5 HGNC:14344 C1R HGNC:1246 C1S HGNC:1247 C21 or F59 HGNC:1301 C2CD3 HGNC:24564 C2 HGNC:1248 C2 or F71 HGNC:34383 C3 HGNC:1318 C4A HGNC:1323 C4B HGNC:1324 C4 or F26 HGNC:26300 C5 HGNC:1331 C5 or F42 HGNC:25801 C6 HGNC:1339 C7 HGNC:1346 C8A HGNC:1352 C8B HGNC:1353 C8 or F37 HGNC:27232 C9 HGNC:1358 C9 or F72 HGNC:28337 CA12 HGNC:1371

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TABLE 4 Continued HGNC Gene Symbol HGNC:ID CA2 HGNC:1373 CA4 HGNC:1375 CA5A HGNC:1377 CA8 HGNC:1382 CABP2 HGNC:1385 CABP4 HGNC:1386 CACNA1A HGNC:1388 CACNA1B HGNC:1389 CACNA1C HGNC:1390 CACNA1D HGNC:1391 CACNA1F HGNC:1393 CACNA1G HGNC:1394 CACNA1H HGNC:1395 CACNA1S HGNC:1397 CACNA2D2 HGNC:1400 CACNA2D4 HGNC:20202 CACNB2 HGNC:1402 CACNB4 HGNC:1404 CACNG2 HGNC:1406 CAD HGNC:1424 CALM1 HGNC:1442 CALM2 HGNC:1445 CALR3 HGNC:20407 CAMK2G HGNC:1463 CAMTA1 HGNC:18806 CANT1 HGNC:19721 CAPN10 HGNC:1477 CAPN3 HGNC:1480 CAPN5 HGNC:1482 CARD11 HGNC:16393 CARD14 HGNC:16446 CARD9 HGNC:16391 CASK HGNC:1497 CASP10 HGNC:1500 CASP2 HGNC:1503 CASP8 HGNC:1509 CASQ1 HGNC:1512 CASQ2 HGNC:1513 CASR HGNC:1514 CAST HGNC:1515 CAT HGNC:1516 CATSPER1 HGNC:17116 CAV1 HGNC:1527 CAV3 HGNC:1529 CBFB HGNC:1539

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article-authors endPage startPage article-title issue volume buildID journal-title copyright proof doi pub-date TABLE 4 Continued HGNC Gene Symbol HGNC:ID CBL HGNC:1541 CBS HGNC:1550 CBX2 HGNC:1552 CC2D1A HGNC:30237 CC2D2A HGNC:29253 CCBE1 HGNC:29426 CCDC103 HGNC:32700 CCDC114 HGNC:26560 CCDC11 HGNC:26530 CCDC137 HGNC:33451 CCDC151 HGNC:28303 CCDC28B HGNC:28163 CCDC39 HGNC:25244 CCDC40 HGNC:26090 CCDC41 HGNC:17966 CCDC50 HGNC:18111 CCDC65 HGNC:29937 CCDC6 HGNC:18782 CCDC78 HGNC:14153 CCDC88C HGNC:19967 CCDC8 HGNC:25367 CCL11 HGNC:10610 CCM2 HGNC:21708 CCNA2 HGNC:1578 CCND1 HGNC:1582 CCND2 HGNC:1583 CCNO HGNC:18576 CCT5 HGNC:1618 CD151 HGNC:1630 CD19 HGNC:1633 CD207 HGNC:17935 CD247 HGNC:1677 CD27 HGNC:11922 CD2AP HGNC:14258 CD320 HGNC:16692 CD36 HGNC:1663 CD3D HGNC:1673 CD3E HGNC:1674 CD3G HGNC:1675 CD40 HGNC:11919 CD40LG HGNC:11935 CD44 HGNC:1681 CD46 HGNC:6953 CD4 HGNC:1678 CD55 HGNC:2665

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TABLE 4 Continued HGNC Gene Symbol HGNC:ID CD59 HGNC:1689 CD79A HGNC:1698 CD79B HGNC:1699 CD81 HGNC:1701 CD8A HGNC:1706 CD96 HGNC:16892 CDAN1 HGNC:1713 CDC6 HGNC:1744 CDC73 HGNC:16783 CDH15 HGNC:1754 CDH1 HGNC:1748 CDH23 HGNC:13733 CDH3 HGNC:1762 CDHR1 HGNC:14550 CDK16 HGNC:8749 CDK19 HGNC:19338 CDK4 HGNC:1773 CDK5 HGNC:1774 CDK5RAP2 HGNC:18672 CDK6 HGNC:1777 CDKL5 HGNC:11411 CDKN1B HGNC:1785 CDKN1C HGNC:1786 CDKN2A HGNC:1787 CDON HGNC:17104 CDR1 HGNC:1798 CDSN HGNC:1802 CDT1 HGNC:24576 CEACAM16 HGNC:31948 CEBPA HGNC:1833 CEBPE HGNC:1836 CECR1 HGNC:1839 CEL HGNC:1848 CENPE HGNC:1856 CENPF HGNC:1857 CENPJ HGNC:17272 CEP120 HGNC:26690 CEP135 HGNC:29086 CEP152 HGNC:29298 CEP164 HGNC:29182 CEP19 HGNC:28209 CEP290 HGNC:29021 CEP41 HGNC:12370 CEP57 HGNC:30794 CEP63 HGNC:25815

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article-authors endPage startPage article-title issue volume buildID journal-title copyright proof doi pub-date TABLE 4 Continued HGNC Gene Symbol HGNC:ID CERKL HGNC:21699 CERS1 HGNC:14253 CERS3 HGNC:23752 CES1 HGNC:1863 CETP HGNC:1869 CFAP57 HGNC:26485 CFB HGNC:1037 CFC1 HGNC:18292 CFD HGNC:2771 CFH HGNC:4883 CFHR1 HGNC:4888 CFHR3 HGNC:16980 CFHR4 HGNC:16979 CFHR5 HGNC:24668 CFI HGNC:5394 CFL2 HGNC:1875 CFP HGNC:8864 CFTR HGNC:1884 CHAMP1 HGNC:20311 CHAT HGNC:1912 CHCHD10 HGNC:15559 CHD2 HGNC:1917 CHD4 HGNC:1919 CHD7 HGNC:20626 CHD8 HGNC:20153 CHEK2 HGNC:16627 CHIT1 HGNC:1936 CHKB HGNC:1938 CHM HGNC:1940 CHMP1A HGNC:8740 CHMP2B HGNC:24537 CHMP4B HGNC:16171 CHN1 HGNC:1943 CHRDL1 HGNC:29861 CHRM3 HGNC:1952 CHRNA1 HGNC:1955 CHRNA2 HGNC:1956 CHRNA4 HGNC:1958 CHRNB1 HGNC:1961 CHRNB2 HGNC:1962 CHRND HGNC:1965 CHRNE HGNC:1966 CHRNG HGNC:1967 CHST14 HGNC:24464 CHST3 HGNC:1971

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TABLE 4 Continued HGNC Gene Symbol HGNC:ID CHST6 HGNC:6938 CHST8 HGNC:15993 CHSY1 HGNC:17198 CHUK HGNC:1974 CIB2 HGNC:24579 CIDEC HGNC:24229 CIITA HGNC:7067 CIRH1A HGNC:1983 CISD2 HGNC:24212 CITED2 HGNC:1987 CIZ1 HGNC:16744 CKAP2L HGNC:26877 CLCF1 HGNC:17412 CLCN1 HGNC:2019 CLCN2 HGNC:2020 CLCN4 HGNC:2022 CLCN5 HGNC:2023 CLCN7 HGNC:2025 CLCNKA HGNC:2026 CLCNKB HGNC:2027 CLDN14 HGNC:2035 CLDN16 HGNC:2037 CLDN19 HGNC:2040 CLDN1 HGNC:2032 CLEC7A HGNC:14558 CLIC2 HGNC:2063 CLIC5 HGNC:13517 CLMP HGNC:24039 CLN3 HGNC:2074 CLN5 HGNC:2076 CLN6 HGNC:2077 CLN8 HGNC:2079 CLP1 HGNC:16999 CLPB HGNC:30664 CLPP HGNC:2084 CLRN1 HGNC:12605 CNBP HGNC:13164 CNGA1 HGNC:2148 CNGA3 HGNC:2150 CNGB1 HGNC:2151 CNGB3 HGNC:2153 CNKSR1 HGNC:19700 CNKSR2 HGNC:19701 CNNM2 HGNC:103

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article-authors endPage startPage article-title issue volume buildID journal-title copyright proof doi pub-date TABLE 4 Continued HGNC Gene Symbol HGNC:ID CNNM4 HGNC:105 CNTN1 HGNC:2171 CNTN2 HGNC:2172 CNTNAP1 HGNC:8011 CNTNAP2 HGNC:13830 COA3 HGNC:24990 COA5 HGNC:33848 COA6 HGNC:18025 COASY HGNC:29932 COCH HGNC:2180 COG1 HGNC:6545 COG4 HGNC:18620 COG5 HGNC:14857 COG6 HGNC:18621 COG7 HGNC:18622 COG8 HGNC:18623 COL10A1 HGNC:2185 COL11A1 HGNC:2186 COL11A2 HGNC:2187 COL12A1 HGNC:2188 COL14A1 HGNC:2191 COL17A1 HGNC:2194 COL18A1 HGNC:2195 COL1A1 HGNC:2197 COL1A2 HGNC:2198 COL25A1 HGNC:18603 COL27A1 HGNC:22986 COL2A1 HGNC:2200 COL3A1 HGNC:2201 COL4A1 HGNC:2202 COL4A2 HGNC:2203 COL4A3BP HGNC:2205 COL4A3 HGNC:2204 COL4A4 HGNC:2206 COL4A5 HGNC:2207 COL4A6 HGNC:2208 COL5A1 HGNC:2209 COL5A2 HGNC:2210 COL6A1 HGNC:2211 COL6A2 HGNC:2212 COL6A3 HGNC:2213 COL7A1 HGNC:2214 COL8A2 HGNC:2216 COL9A1 HGNC:2217 COL9A2 HGNC:2218

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TABLE 4 Continued HGNC Gene Symbol HGNC:ID COL9A3 HGNC:2219 COLEC11 HGNC:17213 COLQ HGNC:2226 COMP HGNC:2227 COMT HGNC:2228 COPA HGNC:2230 COQ2 HGNC:25223 COQ4 HGNC:19693 COQ5 HGNC:28722 COQ6 HGNC:20233 COQ9 HGNC:25302 CORIN HGNC:19012 CORO1A HGNC:2252 COX10 HGNC:2260 COX14 HGNC:28216 COX15 HGNC:2263 COX20 HGNC:26970 COX4I2 HGNC:16232 COX6A1 HGNC:2277 COX6B1 HGNC:2280 COX7B HGNC:2291 CPA6 HGNC:17245 CP HGNC:2295 CPN1 HGNC:2312 CPOX HGNC:2321 CPS1 HGNC:2323 CPT1A HGNC:2328 CPT1C HGNC:18540 CPT2 HGNC:2330 CR1 HGNC:2334 CR2 HGNC:2336 CRADD HGNC:2340 CRB1 HGNC:2343 CRB2 HGNC:18688 CRBN HGNC:30185 CREB1 HGNC:2345 CREB3L1 HGNC:18856 CREBBP HGNC:2348 CRELD1 HGNC:14630 CRIPT HGNC:14312 CRLF1 HGNC:2364 CRTAP HGNC:2379 CRX HGNC:2383 CRYAA HGNC:2388 CRYAB HGNC:2389

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article-authors endPage startPage article-title issue volume buildID journal-title copyright proof doi pub-date TABLE 4 Continued HGNC Gene Symbol HGNC:ID CRYBA1 HGNC:2394 CRYBA2 HGNC:2395 CRYBA4 HGNC:2396 CRYBB1 HGNC:2397 CRYBB2 HGNC:2398 CRYBB3 HGNC:2400 CRYGB HGNC:2409 CRYGC HGNC:2410 CRYGD HGNC:2411 CRYGS HGNC:2417 CRYM HGNC:2418 CSF1R HGNC:2433 CSF2RA HGNC:2435 CSF2RB HGNC:2436 CSF3R HGNC:2439 CSNK1D HGNC:2452 CSPP1 HGNC:26193 CSRP3 HGNC:2472 CST3 HGNC:2475 CSTA HGNC:2481 CSTB HGNC:2482 CSTF2 HGNC:2484 CTC1 HGNC:26169 CTCF HGNC:13723 CTDP1 HGNC:2498 CTGF HGNC:2500 CTH HGNC:2501 CTHRC1 HGNC:18831 CTLA4 HGNC:2505 CTNNA1 HGNC:2509 CTNNA3 HGNC:2511 CTNNB1 HGNC:2514 CTNS HGNC:2518 CTPS1 HGNC:2519 CTSA HGNC:9251 CTSC HGNC:2528 CTSD HGNC:2529 CTSF HGNC:2531 CTSK HGNC:2536 CUBN HGNC:2548 CUL3 HGNC:2553 CUL4B HGNC:2555 CUL7 HGNC:21024 CUX2 HGNC:19347 CWF19L1 HGNC:25613

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TABLE 4 Continued HGNC Gene Symbol HGNC:ID CXCR4 HGNC:2561 CYB5A HGNC:2570 CYB5R3 HGNC:2873 CYBA HGNC:2577 CYBB HGNC:2578 CYC1 HGNC:2579 CYCS HGNC:19986 CYLD HGNC:2584 CYP11A1 HGNC:2590 CYP11B1 HGNC:2591 CYP11B2 HGNC:2592 CYP17A1 HGNC:2593 CYP19A1 HGNC:2594 CYP1A2 HGNC:2596 CYP1B1 HGNC:2597 CYP21A2 HGNC:2600 CYP24A1 HGNC:2602 CYP26B1 HGNC:20581 CYP26C1 HGNC:20577 CYP27A1 HGNC:2605 CYP27B1 HGNC:2606 CYP2A6 HGNC:2610 CYP2B6 HGNC:2615 CYP2C19 HGNC:2621 CYP2C8 HGNC:2622 CYP2C9 HGNC:2623 CYP2D6 HGNC:2625 CYP2R1 HGNC:20580 CYP2U1 HGNC:20582 CYP3A4 HGNC:2637 CYP3A5 HGNC:2638 CYP4F22 HGNC:26820 CYP4F2 HGNC:2645 CYP4V2 HGNC:23198 CYP7B1 HGNC:2652 D2HGDH HGNC:28358 DACT1 HGNC:17748 DAG1 HGNC:2666 DARC HGNC:4035 DARS2 HGNC:25538 DBH HGNC:2689 DBT HGNC:2698 DCAF17 HGNC:25784 DCAF8 HGNC:24891

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article-authors endPage startPage article-title issue volume buildID journal-title copyright proof doi pub-date TABLE 4 Continued HGNC Gene Symbol HGNC:ID DCC HGNC:2701 DCDC2 HGNC:18141 DCHS1 HGNC:13681 DCLRE1C HGNC:17642 DCN HGNC:2705 DCPS HGNC:29812 DCTN1 HGNC:2711 DCX HGNC:2714 DCXR HGNC:18985 DDB1 HGNC:2717 DDB2 HGNC:2718 DDC HGNC:2719 DDHD1 HGNC:19714 DDHD2 HGNC:29106 DDIT3 HGNC:2726 DDOST HGNC:2728 DDR2 HGNC:2731 DDX11 HGNC:2736 DDX3X HGNC:2745 DDX58 HGNC:19102 DDX59 HGNC:25360 DEAF1 HGNC:14677 DEC1 HGNC:23658 DECR1 HGNC:2753 DEPDC5 HGNC:18423 DES HGNC:2770 DFNA5 HGNC:2810 DFNB31 HGNC:16361 DFNB59 HGNC:29502 DGAT1 HGNC:2843 DGCR2 HGNC:2845 DGKE HGNC:2852 DGUOK HGNC:2858 DHCR24 HGNC:2859 DHCR7 HGNC:2860 DHDDS HGNC:20603 DHFR HGNC:2861 DHH HGNC:2865 DHODH HGNC:2867 DHTKD1 HGNC:23537 DIABLO HGNC:21528 DIAPH1 HGNC:2876 DIAPH2 HGNC:2877 DIAPH3 HGNC:15480 DICER1 HGNC:17098

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TABLE 4 Continued HGNC Gene Symbol HGNC:ID DIO1 HGNC:2883 DIP2B HGNC:29284 DIRC2 HGNC:16628 DIS3L2 HGNC:28648 DISP1 HGNC:19711 DKC1 HGNC:2890 DLAT HGNC:2896 DLD HGNC:2898 DLEC1 HGNC:2899 DLG1 HGNC:2900 DLG3 HGNC:2902 DLG5 HGNC:2904 DLL1 HGNC:2908 DLL3 HGNC:2909 DLL4 HGNC:2910 DLX3 HGNC:2916 DLX5 HGNC:2918 DMD HGNC:2928 DMGDH HGNC:24475 DMP1 HGNC:2932 DMPK HGNC:2933 DMRT1 HGNC:2934 DMRT2 HGNC:2935 DMXL2 HGNC:2938 DNA2 HGNC:2939 DNAAF1 HGNC:30539 DNAAF2 HGNC:20188 DNAAF3 HGNC:30492 DNAH11 HGNC:2942 DNAH1 HGNC:2940 DNAH5 HGNC:2950 DNAI1 HGNC:2954 DNAI2 HGNC:18744 DNAJB2 HGNC:5228 DNAJB6 HGNC:14888 DNAJC13 HGNC:30343 DNAJC19 HGNC:30528 DNAJC3 HGNC:9439 DNAJC5 HGNC:16235 DNAJC6 HGNC:15469 DNAL1 HGNC:23247 DNAL4 HGNC:2955 DNASE1L3 HGNC:2959

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article-authors endPage startPage article-title issue volume buildID journal-title copyright proof doi pub-date TABLE 4 Continued HGNC Gene Symbol HGNC:ID DNM1 HGNC:2972 DNM1L HGNC:2973 DNM2 HGNC:2974 DNMT1 HGNC:2976 DNMT3A HGNC:2978 DNMT3B HGNC:2979 DOCK2 HGNC:2988 DOCK6 HGNC:19189 DOCK7 HGNC:19190 DOCK8 HGNC:19191 DOK7 HGNC:26594 DOLK HGNC:23406 DPAGT1 HGNC:2995 DPM1 HGNC:3005 DPM2 HGNC:3006 DPM3 HGNC:3007 DPP6 HGNC:3010 DPY19L2 HGNC:19414 DPYD HGNC:3012 DPYS HGNC:3013 DRAM2 HGNC:28769 DRD2 HGNC:3023 DSC2 HGNC:3036 DSC3 HGNC:3037 DSE HGNC:21144 DSG1 HGNC:3048 DSG2 HGNC:3049 DSG4 HGNC:21307 DSP HGNC:3052 DSPP HGNC:3054 DST HGNC:1090 DSTYK HGNC:29043 DTNA HGNC:3057 DTNBP1 HGNC:17328 DUOX2 HGNC:13273 DUOXA2 HGNC:32698 DUSP6 HGNC:3072 DUX4 HGNC:50800 DVL1 HGNC:3084 DYM HGNC:21317 DYNC1H1 HGNC:2961 DYNC2H1 HGNC:2962 DYRK1A HGNC:3091 DYRK1B HGNC:3092 DYSF HGNC:3097

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TABLE 4 Continued HGNC Gene Symbol HGNC:ID DYX1C1 HGNC:21493 EARS2 HGNC:29419 EBP HGNC:3133 ECE1 HGNC:3146 ECEL1 HGNC:3147 ECEL1P3 HGNC:14018 ECHS1 HGNC:3151 ECM1 HGNC:3153 EDA HGNC:3157 EDARADD HGNC:14341 EDAR HGNC:2895 EDC3 HGNC:26114 EDN1 HGNC:3176 EDN3 HGNC:3178 EDNRA HGNC:3179 EDNRB HGNC:3180 EEF1A2 HGNC:3192 EEF1B2 HGNC:3208 EFEMP1 HGNC:3218 EFEMP2 HGNC:3219 EFHC1 HGNC:16406 EFNB1 HGNC:3226 EFTUD2 HGNC:30858 EGF HGNC:3229 EGFR HGNC:3236 EGLN1 HGNC:1232 EGR2 HGNC:3239 EHHADH HGNC:3247 EHMT1 HGNC:24650 EIF2AK3 HGNC:3255 EIF2AK4 HGNC:19687 EIF2B1 HGNC:3257 EIF2B2 HGNC:3258 EIF2B3 HGNC:3259 EIF2B4 HGNC:3260 EIF2B5 HGNC:3261 EIF2S3 HGNC:3267 EIF4A3 HGNC:18683 EIF4G1 HGNC:3296 ELAC2 HGNC:14198 ELANE HGNC:3309 ELK1 HGNC:3321 ELMOD3 HGNC:26158 ELN HGNC:3327 ELOVL4 HGNC:14415

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article-authors endPage startPage article-title issue volume buildID journal-title copyright proof doi pub-date TABLE 4 Continued HGNC Gene Symbol HGNC:ID ELOVL5 HGNC:21308 ELP2 HGNC:18248 EMD HGNC:3331 EMG1 HGNC:16912 EMP2 HGNC:3334 EMX2 HGNC:3341 ENAM HGNC:3344 ENG HGNC:3349 ENO3 HGNC:3354 ENPP1 HGNC:3356 ENTPD1 HGNC:3363 EOGT HGNC:28526 EP300 HGNC:3373 EPAS1 HGNC:3374 EPB41 HGNC:3377 EPB41L1 HGNC:3378 EPB42 HGNC:3381 EPCAM HGNC:11529 EPG5 HGNC:29331 EPHA2 HGNC:3386 EPHB2 HGNC:3393 EPHX1 HGNC:3401 EPHX2 HGNC:3402 EPM2A HGNC:3413 EPOR HGNC:3416 EPS8 HGNC:3420 EPX HGNC:3423 ERBB2 HGNC:3430 ERBB3 HGNC:3431 ERBB4 HGNC:3432 ERCC1 HGNC:3433 ERCC2 HGNC:3434 ERCC3 HGNC:3435 ERCC4 HGNC:3436 ERCC5 HGNC:3437 ERCC6 HGNC:3438 ERCC6L2 HGNC:26922 ERCC8 HGNC:3439 ERLIN2 HGNC:1356 ERMAP HGNC:15743 ERMARD HGNC:21056 ESAM HGNC:17474 ESCO2 HGNC:27230 ESPN HGNC:13281

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TABLE 4 Continued HGNC Gene Symbol HGNC:ID ESR1 HGNC:3467 ESRRB HGNC:3473 ETFA HGNC:3481 ETFB HGNC:3482 ETFDH HGNC:3483 ETHE1 HGNC:23287 ETV1 HGNC:3490 ETV6 HGNC:3495 EVC2 HGNC:19747 EVC HGNC:3497 EWSR1 HGNC:3508 EXOSC3 HGNC:17944 EXOSC8 HGNC:17035 EXPH5 HGNC:30578 EXT1 HGNC:3512 EXT2 HGNC:3513 EYA1 HGNC:3519 EYA4 HGNC:3522 EYS HGNC:21555 EZH2 HGNC:3527 F10 HGNC:3528 F11 HGNC:3529 F12 HGNC:3530 F13A1 HGNC:3531 F13B HGNC:3534 F2 HGNC:3535 F5 HGNC:3542 F7 HGNC:3544 F8 HGNC:3546 F9 HGNC:3551 FA2H HGNC:21197 FADD HGNC:3573 FAH HGNC:3579 FAM111A HGNC:24725 FAM111B HGNC:24200 FAM126A HGNC:24587 FAM134B HGNC:25964 FAM161A HGNC:25808 FAM20A HGNC:23015 FAM20C HGNC:22140 FAM58A HGNC:28434 FAM65B HGNC:13872 FAM83H HGNC:24797 FAN1 HGNC:29170

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article-authors endPage startPage article-title issue volume buildID journal-title copyright proof doi pub-date TABLE 4 Continued HGNC Gene Symbol HGNC:ID FANCA HGNC:3582 FANCB HGNC:3583 FANCC HGNC:3584 FANCD2 HGNC:3585 FANCE HGNC:3586 FANCF HGNC:3587 FANCG HGNC:3588 FANCI HGNC:25568 FANCL HGNC:20748 FANCM HGNC:23168 FARS2 HGNC:21062 FAS HGNC:11920 FASLG HGNC:11936 FASN HGNC:3594 FASTKD2 HGNC:29160 FAT4 HGNC:23109 FBLN1 HGNC:3600 FBLN5 HGNC:3602 FBN1 HGNC:3603 FBN2 HGNC:3604 FBP1 HGNC:3606 FBXL4 HGNC:13601 FBXO31 HGNC:16510 FBXO38 HGNC:28844 FBXO7 HGNC:13586 FBXW4 HGNC:10847 FCGR2C HGNC:15626 FCGR3A HGNC:3619 FCN3 HGNC:3625 FDPS HGNC:3631 FECH HGNC:3647 FERMT1 HGNC:15889 FERMT3 HGNC:23151 FEZF1 HGNC:22788 FGA HGNC:3661 FGB HGNC:3662 FGD1 HGNC:3663 FGD4 HGNC:19125 FGF10 HGNC:3666 FGF14 HGNC:3671 FGF16 HGNC:3672 FGF17 HGNC:3673 FGF20 HGNC:3677 FGF23 HGNC:3680 FGF3 HGNC:3681

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TABLE 4 Continued HGNC Gene Symbol HGNC:ID FGF5 HGNC:3683 FGF8 HGNC:3686 FGF9 HGNC:3687 FGFR1 HGNC:3688 FGFR2 HGNC:3689 FGFR3 HGNC:3690 FGG HGNC:3694 FH HGNC:3700 FHL1 HGNC:3702 FHL2 HGNC:3703 FIG4 HGNC:16873 FIGLA HGNC:24669 FKBP10 HGNC:18169 FKBP14 HGNC:18625 FKRP HGNC:17997 FKTN HGNC:3622 FLCN HGNC:27310 FLG HGNC:3748 FLI1 HGNC:3749 FLNA HGNC:3754 FLNB HGNC:3755 FLNC HGNC:3756 FLRT3 HGNC:3762 FLT3 HGNC:3765 FLT4 HGNC:3767 FLVCR1 HGNC:24682 FLVCR2 HGNC:20105 FMN2 HGNC:14074 FMO3 HGNC:3771 FMR1 HGNC:3775 FN1 HGNC:3778 FOLR1 HGNC:3791 FOXC1 HGNC:3800 FOXC2 HGNC:3801 FOXE1 HGNC:3806 FOXE3 HGNC:3808 FOXF1 HGNC:3809 FOXG1 HGNC:3811 FOXH1 HGNC:3814 FOXI1 HGNC:3815 FOXL2 HGNC:1092 FOXN1 HGNC:12765 FOXO1 HGNC:3819 FOXO4 HGNC:7139 FOXP1 HGNC:3823

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article-authors endPage startPage article-title issue volume buildID journal-title copyright proof doi pub-date TABLE 4 Continued HGNC Gene Symbol HGNC:ID FOXP2 HGNC:13875 FOXP3 HGNC:6106 FOXRED1 HGNC:26927 FRAS1 HGNC:19185 FREM1 HGNC:23399 FREM2 HGNC:25396 FRG1 HGNC:3954 FRMD7 HGNC:8079 FRMPD4 HGNC:29007 FRY HGNC:20367 FSCN2 HGNC:3960 FSHB HGNC:3964 FSHR HGNC:3969 FTCD HGNC:3974 FTH1 HGNC:3976 FTL HGNC:3999 FTO HGNC:24678 FTSJ1 HGNC:13254 FUCA1 HGNC:4006 FUS HGNC:4010 FUT1 HGNC:4012 FUT3 HGNC:4014 FUT6 HGNC:4017 FUZ HGNC:26219 FXN HGNC:3951 FXYD2 HGNC:4026 FYCO1 HGNC:14673 FZD4 HGNC:4042 FZD6 HGNC:4044 G6PC3 HGNC:24861 G6PC HGNC:4056 G6PD HGNC:4057 GAA HGNC:4065 GABRA1 HGNC:4075 GABRA3 HGNC:4077 GABRB3 HGNC:4083 GABRD HGNC:4084 GABRG2 HGNC:4087 GAD1 HGNC:4092 GALC HGNC:4115 GALE HGNC:4116 GAL HGNC:4114 GALK1 HGNC:4118 GALNS HGNC:4122 GALNT12 HGNC:19877

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TABLE 4 Continued HGNC Gene Symbol HGNC:ID GALNT3 HGNC:4125 GALT HGNC:4135 GAMT HGNC:4136 GAN HGNC:4137 GARS HGNC:4162 GAS1 HGNC:4165 GATA1 HGNC:4170 GATA2 HGNC:4171 GATA3 HGNC:4172 GATA4 HGNC:4173 GATA6 HGNC:4174 GATAD1 HGNC:29941 GATAD2B HGNC:30778 GATM HGNC:4175 GBA2 HGNC:18986 GBA HGNC:4177 GBE1 HGNC:4180 GCDH HGNC:4189 GCH1 HGNC:4193 GCK HGNC:4195 GCLC HGNC:4311 GCM2 HGNC:4198 GCNT2 HGNC:4204 GCSH HGNC:4208 GDAP1 HGNC:15968 GDF1 HGNC:4214 GDF2 HGNC:4217 GDF3 HGNC:4218 GDF5 HGNC:4220 GDF6 HGNC:4221 GDI1 HGNC:4226 GDNF HGNC:4232 GFAP HGNC:4235 GFER HGNC:4236 GFI1B HGNC:4238 GFI1 HGNC:4237 GFM1 HGNC:13780 GFPT1 HGNC:4241 GGCX HGNC:4247 GH1 HGNC:4261 GHR HGNC:4263 GHRH HGNC:4265 GHRHR HGNC:4266 GHSR HGNC:4267 GIF HGNC:4268

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article-authors endPage startPage article-title issue volume buildID journal-title copyright proof doi pub-date TABLE 4 Continued HGNC Gene Symbol HGNC:ID GIGYF2 HGNC:11960 GIPC3 HGNC:18183 GJA1 HGNC:4274 GJA3 HGNC:4277 GJA5 HGNC:4279 GJA8 HGNC:4281 GJB1 HGNC:4283 GJB2 HGNC:4284 GJB3 HGNC:4285 GJB4 HGNC:4286 GJB6 HGNC:4288 GJC2 HGNC:17494 GK HGNC:4289 GLA HGNC:4296 GLB1 HGNC:4298 GLDC HGNC:4313 GLE1 HGNC:4315 GLI2 HGNC:4318 GLI3 HGNC:4319 GLIS2 HGNC:29450 GLIS3 HGNC:28510 GLMN HGNC:14373 GLRA1 HGNC:4326 GLRB HGNC:4329 GLRX5 HGNC:20134 GLUD1 HGNC:4335 GLUL HGNC:4341 GLYCTK HGNC:24247 GM2A HGNC:4367 GMPPA HGNC:22923 GMPPB HGNC:22932 GMPS HGNC:4378 GNA11 HGNC:4379 GNAI2 HGNC:4385 GNAI3 HGNC:4387 GNAL HGNC:4388 GNAO1 HGNC:4389 GNAS HGNC:4392 GNAT1 HGNC:4393 GNAT2 HGNC:4394 GNB4 HGNC:20731 GNE HGNC:23657 GNMT HGNC:4415 GNPAT HGNC:4416 GNPTAB HGNC:29670

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TABLE 4 Continued HGNC Gene Symbol HGNC:ID GNPTG HGNC:23026 GNRH1 HGNC:4419 GNRHR HGNC:4421 GNS HGNC:4422 GOLGA5 HGNC:4428 GON4L HGNC:25973 GOPC HGNC:17643 GORAB HGNC:25676 GOSR2 HGNC:4431 GOT1 HGNC:4432 GP1BA HGNC:4439 GP1BB HGNC:4440 GP6 HGNC:14388 GP9 HGNC:4444 GPC3 HGNC:4451 GPC6 HGNC:4454 GPD1 HGNC:4455 GPD1L HGNC:28956 GPHN HGNC:15465 GPIHBP1 HGNC:24945 GPI HGNC:4458 GPR101 HGNC:14963 GPR126 HGNC:13841 GPR143 HGNC:20145 GPR179 HGNC:31371 GPR56 HGNC:4512 GPR98 HGNC:17416 GPSM2 HGNC:29501 GPT2 HGNC:18062 GPX1 HGNC:4553 GPX4 HGNC:4556 GRHL2 HGNC:2799 GRHL3 HGNC:25839 GRHPR HGNC:4570 GRIA1 HGNC:4571 GRIA3 HGNC:4573 GRID2 HGNC:4576 GRIK2 HGNC:4580 GRIK4 HGNC:4582 GRIN1 HGNC:4584 GRIN2A HGNC:4585 GRIN2B HGNC:4586 GRIP1 HGNC:18708 GRK1 HGNC:10013 GRM1 HGNC:4593

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article-authors endPage startPage article-title issue volume buildID journal-title copyright proof doi pub-date TABLE 4 Continued HGNC Gene Symbol HGNC:ID GRM6 HGNC:4598 GRN HGNC:4601 GRPR HGNC:4609 GRXCR1 HGNC:31673 GRXCR2 HGNC:33862 GSC HGNC:4612 GSN HGNC:4620 GSS HGNC:4624 GTF2H5 HGNC:21157 GTPBP3 HGNC:14880 GUCA1A HGNC:4678 GUCA1B HGNC:4679 GUCY1A3 HGNC:4685 GUCY2C HGNC:4688 GUCY2D HGNC:4689 GUSB HGNC:4696 GYG1 HGNC:4699 GYPA HGNC:4702 GYPB HGNC:4703 GYPC HGNC:4704 GYS1 HGNC:4706 GYS2 HGNC:4707 H19 HGNC:4713 H6PD HGNC:4795 HABP2 HGNC:4798 HACE1 HGNC:21033 HADHA HGNC:4801 HADHB HGNC:4803 HADH HGNC:4799 HAGH HGNC:4805 HAL HGNC:4806 HAMP HGNC:15598 HARS2 HGNC:4817 HARS HGNC:4816 HAX1 HGNC:16915 HBA1 HGNC:4823 HBA2 HGNC:4824 HBB HGNC:4827 HBD HGNC:4829 HBG1 HGNC:4831 HBG2 HGNC:4832 HCCS HGNC:4837 HCFC1 HGNC:4839 HCN1 HGNC:4845 HCN4 HGNC:16882

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TABLE 4 Continued HGNC Gene Symbol HGNC:ID HCRT HGNC:4847 HDAC4 HGNC:14063 HDAC6 HGNC:14064 HDAC8 HGNC:13315 HDC HGNC:4855 HEATR2 HGNC:26013 HEPACAM HGNC:26361 HERC2 HGNC:4868 HES7 HGNC:15977 HESX1 HGNC:4877 HEXA HGNC:4878 HEXB HGNC:4879 HFE2 HGNC:4887 HFE HGNC:4886 HFM1 HGNC:20193 HGD HGNC:4892 HGF HGNC:4893 HGSNAT HGNC:26527 HIBCH HGNC:4908 HINT1 HGNC:4912 HIP1 HGNC:4913 HIRA HGNC:4916 HIST1H4B HGNC:4789 HIST3H3 HGNC:4778 HIVEP2 HGNC:4921 HK1 HGNC:4922 HLA-A HGNC:4931 HLA-B HGNC:4932 HLA-DQB1 HGNC:4944 HLA-DRA HGNC:4947 HLA-DRB1 HGNC:4948 HLCS HGNC:4976 HMBS HGNC:4982 HMGA1 HGNC:5010 HMGA2 HGNC:5009 HMGB3 HGNC:5004 HMGCL HGNC:5005 HMGCR HGNC:5006 HMGCS2 HGNC:5008 HMOX1 HGNC:5013 HMX1 HGNC:5017 HNF1A HGNC:11621 HNF1B HGNC:11630 HNF4A HGNC:5024 HNRNPA1 HGNC:5031

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article-authors endPage startPage article-title issue volume buildID journal-title copyright proof doi pub-date TABLE 4 Continued HGNC Gene Symbol HGNC:ID HNRNPA2B1 HGNC:5033 HNRNPDL HGNC:5037 HNRNPK HGNC:5044 HOGA1 HGNC:25155 HOXA11 HGNC:5101 HOXA13 HGNC:5102 HOXA1 HGNC:5099 HOXA2 HGNC:5103 HOXB1 HGNC:5111 HOXC13 HGNC:5125 HOXD10 HGNC:5133 HOXD13 HGNC:5136 HPCA HGNC:5144 HPD HGNC:5147 HPGD HGNC:5154 HP HGNC:5141 HPRT1 HGNC:5157 HPS1 HGNC:5163 HPS3 HGNC:15597 HPS4 HGNC:15844 HPS5 HGNC:17022 HPS6 HGNC:18817 HPSE2 HGNC:18374 HRAS HGNC:5173 HRG HGNC:5181 HR HGNC:5172 HS6ST1 HGNC:5201 HSD11B1 HGNC:5208 HSD11B2 HGNC:5209 HSD17B10 HGNC:4800 HSD17B3 HGNC:5212 HSD17B4 HGNC:5213 HSD3B2 HGNC:5218 HSD3B7 HGNC:18324 HSF4 HGNC:5227 HSPA1L HGNC:5234 HSPB1 HGNC:5246 HSPB3 HGNC:5248 HSPB8 HGNC:30171 HSPD1 HGNC:5261 HSPG2 HGNC:5273 HTR1A HGNC:5286 HTR2A HGNC:5293 HTRA1 HGNC:9476 HTRA2 HGNC:14348

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TABLE 4 Continued HGNC Gene Symbol HGNC:ID HTT HGNC:4851 HUWE1 HGNC:30892 HYAL1 HGNC:5320 HYDIN HGNC:19368 HYLS1 HGNC:26558 IARS2 HGNC:29685 IBA57 HGNC:27302 ICAM1 HGNC:5344 ICAM4 HGNC:5347 ICK HGNC:21219 ICOS HGNC:5351 IDH2 HGNC:5383 IDH3B HGNC:5385 IDS HGNC:5389 IDUA HGNC:5391 IER3IP1 HGNC:18550 IFIH1 HGNC:18873 IFITM5 HGNC:16644 IFNAR2 HGNC:5433 IFNG HGNC:5438 IFNGR1 HGNC:5439 IFNGR2 HGNC:5440 IFNL3 HGNC:18365 IFT122 HGNC:13556 IFT140 HGNC:29077 IFT172 HGNC:30391 IFT27 HGNC:18626 IFT43 HGNC:29669 IFT80 HGNC:29262 IFT88 HGNC:20606 IGBP1 HGNC:5461 IGF1 HGNC:5464 IGF1R HGNC:5465 IGF2 HGNC:5466 IGFALS HGNC:5468 IGFBP7 HGNC:5476 IGHMBP2 HGNC:5542 IGHM HGNC:5541 IGKC HGNC:5716 IGLL1 HGNC:5870 IGSF1 HGNC:5948 IGSF3 HGNC:5950 IHH HGNC:5956 IKBKAP HGNC:5959 IKBKB HGNC:5960

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article-authors endPage startPage article-title issue volume buildID journal-title copyright proof doi pub-date TABLE 4 Continued HGNC Gene Symbol HGNC:ID IKBKG HGNC:5961 IL10 HGNC:5962 IL10RA HGNC:5964 IL10RB HGNC:5965 IL11RA HGNC:5967 IL12B HGNC:5970 IL12RB1 HGNC:5971 IL17F HGNC:16404 IL17RA HGNC:5985 IL17RC HGNC:18358 IL17RD HGNC:17616 IL1RAPL1 HGNC:5996 IL1RN HGNC:6000 IL21 HGNC:6005 IL21R HGNC:6006 IL2RA HGNC:6008 IL2RG HGNC:6010 IL31RA HGNC:18969 IL36RN HGNC:15561 IL4R HGNC:6015 IL7R HGNC:6024 ILDR1 HGNC:28741 IMPAD1 HGNC:26019 IMPDH1 HGNC:6052 IMPDH2 HGNC:6053 IMPG1 HGNC:6055 IMPG2 HGNC:18362 INF2 HGNC:23791 ING1 HGNC:6062 INPP4A HGNC:6074 INPP5E HGNC:21474 INPPL1 HGNC:6080 INS HGNC:6081 INSL3 HGNC:6086 INSR HGNC:6091 INVS HGNC:17870 IPMK HGNC:20739 IQCB1 HGNC:28949 IQSEC2 HGNC:29059 IRAK4 HGNC:17967 IRF1 HGNC:6116 IRF3 HGNC:6118 IRF4 HGNC:6119 IRF6 HGNC:6121 IRF7 HGNC:6122

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TABLE 4 Continued HGNC Gene Symbol HGNC:ID IRF8 HGNC:5358 IRGM HGNC:29597 IRX5 HGNC:14361 ISCA2 HGNC:19857 ISCU HGNC:29882 ISG15 HGNC:4053 ISPD HGNC:37276 ITCH HGNC:13890 ITGA2B HGNC:6138 ITGA2 HGNC:6137 ITGA3 HGNC:6139 ITGA6 HGNC:6142 ITGA7 HGNC:6143 ITGA8 HGNC:6144 ITGAM HGNC:6149 ITGB2 HGNC:6155 ITGB3 HGNC:6156 ITGB4 HGNC:6158 ITGB6 HGNC:6161 ITK HGNC:6171 ITM2B HGNC:6174 ITPA HGNC:6176 ITPR1 HGNC:6180 ITPR2 HGNC:6181 IVD HGNC:6186 IYD HGNC:21071 JAG1 HGNC:6188 JAGN1 HGNC:26926 JAK2 HGNC:6192 JAK3 HGNC:6193 JAM3 HGNC:15532 JPH2 HGNC:14202 JPH3 HGNC:14203 JUP HGNC:6207 KAL1 HGNC:6211 KANK1 HGNC:19309 KANK2 HGNC:29300 KANSL1 HGNC:24565 KARS HGNC:6215 KAT6A HGNC:13013 KAT6B HGNC:17582 KATNB1 HGNC:6217 KBTBD13 HGNC:37227 KCNA1 HGNC:6218 KCNA2 HGNC:6220

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article-authors endPage startPage article-title issue volume buildID journal-title copyright proof doi pub-date TABLE 4 Continued HGNC Gene Symbol HGNC:ID KCNA5 HGNC:6224 KCNC1 HGNC:6233 KCNC3 HGNC:6235 KCND3 HGNC:6239 KCNE1 HGNC:6240 KCNE2 HGNC:6242 KCNE3 HGNC:6243 KCNE5 HGNC:6241 KCNH1 HGNC:6250 KCNH2 HGNC:6251 KCNJ10 HGNC:6256 KCNJ11 HGNC:6257 KCNJ13 HGNC:6259 KCNJ18 HGNC:39080 KCNJ1 HGNC:6255 KCNJ2 HGNC:6263 KCNJ5 HGNC:6266 KCNJ6 HGNC:6267 KCNJ8 HGNC:6269 KCNK3 HGNC:6278 KCNK9 HGNC:6283 KCNMA1 HGNC:6284 KCNQ1 HGNC:6294 KCNQ1OT1 HGNC:6295 KCNQ2 HGNC:6296 KCNQ3 HGNC:6297 KCNQ4 HGNC:6298 KCNT1 HGNC:18865 KCNV2 HGNC:19698 KCTD17 HGNC:25705 KCTD7 HGNC:21957 KDM5A HGNC:9886 KDM5C HGNC:11114 KDM6A HGNC:12637 KDM6B HGNC:29012 KDR HGNC:6307 KEL HGNC:6308 KERA HGNC:6309 KHDC3L HGNC:33699 KHK HGNC:6315 KIAA0196 HGNC:28984 KIAA0226 HGNC:28991 KIAA0586 HGNC:19960 KIAA1033 HGNC:29174 KIAA1279 HGNC:23419

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TABLE 4 Continued HGNC Gene Symbol HGNC:ID KIAA2022 HGNC:29433 KIF11 HGNC:6388 KIF14 HGNC:19181 KIF1A HGNC:888 KIF1B HGNC:16636 KIF1C HGNC:6317 KIF21A HGNC:19349 KIF22 HGNC:6391 KIF2A HGNC:6318 KIF4A HGNC:13339 KIF5A HGNC:6323 KIF5C HGNC:6325 KIF7 HGNC:30497 KIRREL3 HGNC:23204 KISS1 HGNC:6341 KISS1R HGNC:4510 KIT HGNC:6342 KITLG HGNC:6343 KLF11 HGNC:11811 KLF1 HGNC:6345 KLF6 HGNC:2235 KLHDC8B HGNC:28557 KL HGNC:6344 KLHL10 HGNC:18829 KLHL15 HGNC:29347 KLHL3 HGNC:6354 KLHL40 HGNC:30372 KLHL41 HGNC:16905 KLHL7 HGNC:15646 KLK4 HGNC:6365 KLKB1 HGNC:6371 KLLN HGNC:37212 KMT2A HGNC:7132 KMT2D HGNC:7133 KNG1 HGNC:6383 KNL1 HGNC:24054 KPTN HGNC:6404 KRAS HGNC:6407 KRIT1 HGNC:1573 KRT10 HGNC:6413 KRT12 HGNC:6414 KRT13 HGNC:6415 KRT14 HGNC:6416 KRT16 HGNC:6423 KRT17 HGNC:6427

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article-authors endPage startPage article-title issue volume buildID journal-title copyright proof doi pub-date TABLE 4 Continued HGNC Gene Symbol HGNC:ID KRT1 HGNC:6412 KRT2 HGNC:6439 KRT3 HGNC:6440 KRT4 HGNC:6441 KRT5 HGNC:6442 KRT6A HGNC:6443 KRT6B HGNC:6444 KRT6C HGNC:20406 KRT71 HGNC:28927 KRT74 HGNC:28929 KRT75 HGNC:24431 KRT81 HGNC:6458 KRT83 HGNC:6460 KRT85 HGNC:6462 KRT86 HGNC:6463 KRT9 HGNC:6447 KYNU HGNC:6469 L1CAM HGNC:6470 L2HGDH HGNC:20499 LAMA1 HGNC:6481 LAMA2 HGNC:6482 LAMA3 HGNC:6483 LAMA4 HGNC:6484 LAMB1 HGNC:6486 LAMB2 HGNC:6487 LAMB3 HGNC:6490 LAMC2 HGNC:6493 LAMC3 HGNC:6494 LAMP2 HGNC:6501 LAMTOR2 HGNC:29796 LARGE HGNC:6511 LARP7 HGNC:24912 LARS2 HGNC:17095 LARS HGNC:6512 LAS1L HGNC:25726 LBR HGNC:6518 LCA5 HGNC:31923 LCAT HGNC:6522 LCK HGNC:6524 LCT HGNC:6530 LDB3 HGNC:15710 LDHA HGNC:6535 LDHB HGNC:6541 LDLRAP1 HGNC:18640 LDLR HGNC:6547

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TABLE 4 Continued HGNC Gene Symbol HGNC:ID LEFTY2 HGNC:3122 LEMD3 HGNC:28887 LEP HGNC:6553 LEPRE1 HGNC:19316 LEPREL1 HGNC:19317 LEPR HGNC:6554 LFNG HGNC:6560 LGI1 HGNC:6572 LHB HGNC:6584 LHCGR HGNC:6585 LHFPL5 HGNC:21253 LHX3 HGNC:6595 LHX4 HGNC:21734 LIAS HGNC:16429 LIFR HGNC:6597 LIG4 HGNC:6601 LIM2 HGNC:6610 LIN28B HGNC:32207 LINS HGNC:30922 LIPA HGNC:6617 LIPC HGNC:6619 LIPE HGNC:6621 LIPH HGNC:18483 LIPI HGNC:18821 LIPN HGNC:23452 LIPT1 HGNC:29569 LITAF HGNC:16841 LMAN1 HGNC:6631 LMBR1 HGNC:13243 LMBRD1 HGNC:23038 LMF1 HGNC:14154 LMNA HGNC:6636 LMNB1 HGNC:6637 LMNB2 HGNC:6638 LMX1B HGNC:6654 LONP1 HGNC:9479 LOR HGNC:6663 LOXHD1 HGNC:26521 LPA HGNC:6667 LPAR6 HGNC:15520 LPIN1 HGNC:13345 LPIN2 HGNC:14450 LPL HGNC:6677

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article-authors endPage startPage article-title issue volume buildID journal-title copyright proof doi pub-date TABLE 4 Continued HGNC Gene Symbol HGNC:ID LPP HGNC:6679 LRAT HGNC:6685 LRBA HGNC:1742 LRIG2 HGNC:20889 LRIT3 HGNC:24783 LRP1 HGNC:6692 LRP2 HGNC:6694 LRP4 HGNC:6696 LRP5 HGNC:6697 LRP6 HGNC:6698 LRPAP1 HGNC:6701 LRPPRC HGNC:15714 LRRC6 HGNC:16725 LRRC8A HGNC:19027 LRRK2 HGNC:18618 LRSAM1 HGNC:25135 LRTOMT HGNC:25033 LSS HGNC:6708 LTBP2 HGNC:6715 LTBP3 HGNC:6716 LTBP4 HGNC:6717 LTC4S HGNC:6719 LYRM4 HGNC:21365 LYRM7 HGNC:28072 LYST HGNC:1968 LYZ HGNC:6740 LZTFL1 HGNC:6741 LZTR1 HGNC:6742 LZTS1 HGNC:13861 MAB21L2 HGNC:6758 MAD1L1 HGNC:6762 MAFB HGNC:6408 MAF HGNC:6776 MAGEL2 HGNC:6814 MAGT1 HGNC:28880 MAK HGNC:6816 MALT1 HGNC:6819 MAMLD1 HGNC:2568 MAN1B1 HGNC:6823 MAN2B1 HGNC:6826 MANBA HGNC:6831 MAOA HGNC:6833 MAOB HGNC:6834 MAP2K1 HGNC:6840 MAP2K2 HGNC:6842

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TABLE 4 Continued HGNC Gene Symbol HGNC:ID MAP3K14 HGNC:6853 MAP3K1 HGNC:6848 MAP3K6 HGNC:6858 MAP3K8 HGNC:6860 MAPK10 HGNC:6872 MAPK8IP1 HGNC:6882 MAPT HGNC:6893 MARS2 HGNC:25133 MARS HGNC:6898 MARVELD2 HGNC:26401 MASP1 HGNC:6901 MASP2 HGNC:6902 MASTL HGNC:19042 MAT1A HGNC:6903 MATN3 HGNC:6909 MATR3 HGNC:6912 MAX HGNC:6913 MBD5 HGNC:20444 MBL2 HGNC:6922 MBTPS2 HGNC:15455 MC1R HGNC:6929 MC2R HGNC:6930 MC4R HGNC:6932 MCCC1 HGNC:6936 MCCC2 HGNC:6937 MCEE HGNC:16732 MCF2 HGNC:6940 MCFD2 HGNC:18451 MCM10 HGNC:18043 MCM4 HGNC:6947 MCM6 HGNC:6949 MCM8 HGNC:16147 MCM9 HGNC:21484 MCOLN1 HGNC:13356 MCPH1 HGNC:6954 MECP2 HGNC:6990 MED12 HGNC:11957 MED13L HGNC:22962 MED17 HGNC:2375 MED23 HGNC:2372 MED25 HGNC:28845 MEF2C HGNC:6996 MEFV HGNC:6998 MEGF10 HGNC:29634 MEGF8 HGNC:3233

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article-authors endPage startPage article-title issue volume buildID journal-title copyright proof doi pub-date TABLE 4 Continued HGNC Gene Symbol HGNC:ID MEN1 HGNC:7010 MEOX1 HGNC:7013 MERTK HGNC:7027 MESP2 HGNC:29659 MET HGNC:7029 METTL23 HGNC:26988 MFAP5 HGNC:29673 MFN2 HGNC:16877 MFRP HGNC:18121 MFSD2A HGNC:25897 MFSD8 HGNC:28486 MGAT2 HGNC:7045 MGME1 HGNC:16205 MGP HGNC:7060 MIB1 HGNC:21086 MICU1 HGNC:1530 MID1 HGNC:7095 MID2 HGNC:7096 MIF HGNC:7097 MINPP1 HGNC:7102 MIP HGNC:7103 MIPOL1 HGNC:21460 MIR17HG HGNC:23564 MIR184 HGNC:31555 MIR96 HGNC:31648 MITF HGNC:7105 MKKS HGNC:7108 MKRN3 HGNC:7114 MKS1 HGNC:7121 MLC1 HGNC:17082 MLF1 HGNC:7125 MLH1 HGNC:7127 MLH3 HGNC:7128 MLLT10 HGNC:16063 MLPH HGNC:29643 MLYCD HGNC:7150 MMAA HGNC:18871 MMAB HGNC:19331 MMACHC HGNC:24525 MMADHC HGNC:25221 MMP13 HGNC:7159 MMP14 HGNC:7160 MMP19 HGNC:7165 MMP1 HGNC:7155 MMP20 HGNC:7167

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TABLE 4 Continued HGNC Gene Symbol HGNC:ID MMP2 HGNC:7166 MMP9 HGNC:7176 MN1 HGNC:7180 MNX1 HGNC:4979 MOCS1 HGNC:7190 MOCS2 HGNC:7193 MOG HGNC:7197 MOGS HGNC:24862 MPC1 HGNC:21606 MPDU1 HGNC:7207 MPDZ HGNC:7208 MPI HGNC:7216 MPL HGNC:7217 MPLKIP HGNC:16002 MPO HGNC:7218 MPV17 HGNC:7224 MPZ HGNC:7225 MR1 HGNC:4975 MRAP HGNC:1304 MRE11A HGNC:7230 MRPL3 HGNC:10379 MRPL44 HGNC:16650 MRPS16 HGNC:14048 MRPS22 HGNC:14508 MS4A1 HGNC:7315 MSH2 HGNC:7325 MSH3 HGNC:7326 MSH6 HGNC:7329 MSR1 HGNC:7376 MSRB3 HGNC:27375 MSTN HGNC:4223 MSX1 HGNC:7391 MSX2 HGNC:7392 MTAP HGNC:7413 MT-ATP6 HGNC:7414 MT-ATP8 HGNC:7415 MT-CO1 HGNC:7419 MT-CO2 HGNC:7421 MT-CO3 HGNC:7422 MT-CYB HGNC:7427 MTF1 HGNC:7428 MTFMT HGNC:29666 MTHFD1 HGNC:7432 MTHFR HGNC:7436 MTM1 HGNC:7448

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article-authors endPage startPage article-title issue volume buildID journal-title copyright proof doi pub-date TABLE 4 Continued HGNC Gene Symbol HGNC:ID MTMR2 HGNC:7450 MT-ND1 HGNC:7455 MT-ND2 HGNC:7456 MT-ND3 HGNC:7458 MT-ND4 HGNC:7459 MT-ND4L HGNC:7460 MT-ND5 HGNC:7461 MT-ND6 HGNC:7462 MTO1 HGNC:19261 MTOR HGNC:3942 MTPAP HGNC:25532 MTR HGNC:7468 MT-RNR1 HGNC:7470 MT-RNR2 HGNC:7471 MTRR HGNC:7473 MT-TC HGNC:7477 MT-TE HGNC:7479 MT-TF HGNC:7481 MT-TH HGNC:7487 MT-TI HGNC:7488 MT-TK HGNC:7489 MT-TL1 HGNC:7490 MTTP HGNC:7467 MT-TP HGNC:7494 MT-TQ HGNC:7495 MT-TS1 HGNC:7497 MT-TS2 HGNC:7498 MT-TT HGNC:7499 MUSK HGNC:7525 MUT HGNC:7526 MUTYH HGNC:7527 MVD HGNC:7529 MVK HGNC:7530 MYB HGNC:7545 MYBPC1 HGNC:7549 MYBPC3 HGNC:7551 MYC HGNC:7553 MYCN HGNC:7559 MYD88 HGNC:7562 MYF6 HGNC:7566 MYH11 HGNC:7569 MYH14 HGNC:23212 MYH2 HGNC:7572 MYH3 HGNC:7573 MYH6 HGNC:7576

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TABLE 4 Continued HGNC Gene Symbol HGNC:ID MYH7 HGNC:7577 MYH8 HGNC:7578 MYH9 HGNC:7579 MYL2 HGNC:7583 MYL3 HGNC:7584 MYLK2 HGNC:16243 MYLK HGNC:7590 MYO15A HGNC:7594 MYO18B HGNC:18150 MYO1A HGNC:7595 MYO1E HGNC:7599 MYO3A HGNC:7601 MYO5A HGNC:7602 MYO5B HGNC:7603 MYO6 HGNC:7605 MYO7A HGNC:7606 MYOC HGNC:7610 MYOT HGNC:12399 MYOZ2 HGNC:1330 MYPN HGNC:23246 MYT1L HGNC:7623 NAA10 HGNC:18704 NADK2 HGNC:26404 NAGA HGNC:7631 NAGLU HGNC:7632 NAGS HGNC:17996 NALCN HGNC:19082 NANOS1 HGNC:23044 NARS2 HGNC:26274 NAT1 HGNC:7645 NAT2 HGNC:7646 NAT8L HGNC:26742 NBAS HGNC:15625 NBEAL2 HGNC:31928 NBN HGNC:7652 NCF1 HGNC:7660 NCF2 HGNC:7661 NCF4 HGNC:7662 NCOA4 HGNC:7671 NCSTN HGNC:17091 NDE1 HGNC:17619 NDN HGNC:7675 NDP HGNC:7678 NDRG1 HGNC:7679 NDST1 HGNC:7680

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article-authors endPage startPage article-title issue volume buildID journal-title copyright proof doi pub-date TABLE 4 Continued HGNC Gene Symbol HGNC:ID NDUFA10 HGNC:7684 NDUFA11 HGNC:20371 NDUFA12 HGNC:23987 NDUFA13 HGNC:17194 NDUFA1 HGNC:7683 NDUFA2 HGNC:7685 NDUFA9 HGNC:7693 NDUFAF1 HGNC:18828 NDUFAF2 HGNC:28086 NDUFAF3 HGNC:29918 NDUFAF4 HGNC:21034 NDUFAF5 HGNC:15899 NDUFAF6 HGNC:28625 NDUFB11 HGNC:20372 NDUFB3 HGNC:7698 NDUFS1 HGNC:7707 NDUFS2 HGNC:7708 NDUFS3 HGNC:7710 NDUFS4 HGNC:7711 NDUFS6 HGNC:7713 NDUFS7 HGNC:7714 NDUFS8 HGNC:7715 NDUFV1 HGNC:7716 NDUFV2 HGNC:7717 NEB HGNC:7720 NECAP1 HGNC:24539 NEFL HGNC:7739 NEK1 HGNC:7744 NEK2 HGNC:7745 NEK8 HGNC:13387 NEU1 HGNC:7758 NEUROD1 HGNC:7762 NEUROG3 HGNC:13806 NEXN HGNC:29557 NF1 HGNC:7765 NF2 HGNC:7773 NFIX HGNC:7788 NFKB1 HGNC:7794 NFKB2 HGNC:7795 NFKBIA HGNC:7797 NFU1 HGNC:16287 NGF HGNC:7808 NGLY1 HGNC:17646 NHEJ1 HGNC:25737 NHLRC1 HGNC:21576

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TABLE 4 Continued HGNC Gene Symbol HGNC:ID NHP2 HGNC:14377 NHS HGNC:7820 NIN HGNC:14906 NIPA1 HGNC:17043 NIPAL4 HGNC:28018 NIPBL HGNC:28862 NKX2-1 HGNC:11825 NKX2-5 HGNC:2488 NKX2-6 HGNC:32940 NKX3-2 HGNC:951 NLGN3 HGNC:14289 NLGN4X HGNC:14287 NLRC4 HGNC:16412 NLRP12 HGNC:22938 NLRP1 HGNC:14374 NLRP3 HGNC:16400 NLRP7 HGNC:22947 NME1 HGNC:7849 NME8 HGNC:16473 NMNAT1 HGNC:17877 NNT HGNC:7863 NOBOX HGNC:22448 NOD2 HGNC:5331 NODAL HGNC:7865 NOG HGNC:7866 NOL3 HGNC:7869 NOP10 HGNC:14378 NOP56 HGNC:15911 NOTCH1 HGNC:7881 NOTCH2 HGNC:7882 NOTCH3 HGNC:7883 NPC1 HGNC:7897 NPC1L1 HGNC:7898 NPC2 HGNC:14537 NPHP1 HGNC:7905 NPHP3 HGNC:7907 NPHP4 HGNC:19104 NPHS1 HGNC:7908 NPHS2 HGNC:13394 NPM1 HGNC:7910 NPPA HGNC:7939 NPR2 HGNC:7944 NR0B1 HGNC:7960 NR0B2 HGNC:7961 NR2E3 HGNC:7974

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article-authors endPage startPage article-title issue volume buildID journal-title copyright proof doi pub-date TABLE 4 Continued HGNC Gene Symbol HGNC:ID NR2F1 HGNC:7975 NR2F2 HGNC:7976 NR3C1 HGNC:7978 NR3C2 HGNC:7979 NR4A3 HGNC:7982 NR5A1 HGNC:7983 NRAS HGNC:7989 NRIP1 HGNC:8001 NRL HGNC:8002 NRTN HGNC:8007 NRXN1 HGNC:8008 NSD1 HGNC:14234 NSDHL HGNC:13398 NSMF HGNC:29843 NSUN2 HGNC:25994 NT5C2 HGNC:8022 NT5C3A HGNC:17820 NT5E HGNC:8021 NTF4 HGNC:8024 NTHL1 HGNC:8028 NTNG1 HGNC:23319 NTRK1 HGNC:8031 NTRK2 HGNC:8032 NUBPL HGNC:20278 NUP155 HGNC:8063 NUP214 HGNC:8064 NUP62 HGNC:8066 NXF5 HGNC:8075 NYX HGNC:8082 OAT HGNC:8091 OBSL1 HGNC:29092 OCA2 HGNC:8101 OCLN HGNC:8104 OCRL HGNC:8108 ODAM HGNC:26043 OFD1 HGNC:2567 OGDH HGNC:8124 OGG1 HGNC:8125 OPA1 HGNC:8140 OPA3 HGNC:8142 OPHN1 HGNC:8148 OPLAH HGNC:8149 OPN1LW HGNC:9936 OPN1MW HGNC:4206 OPN1SW HGNC:1012

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TABLE 4 Continued HGNC Gene Symbol HGNC:ID OPTN HGNC:17142 ORAI1 HGNC:25896 ORC1 HGNC:8487 ORC4 HGNC:8490 ORC6 HGNC:17151 OSBPL2 HGNC:15761 OSMR HGNC:8507 OSTM1 HGNC:21652 OTC HGNC:8512 OTOA HGNC:16378 OTOF HGNC:8515 OTOG HGNC:8516 OTOGL HGNC:26901 OTX2 HGNC:8522 OXCT1 HGNC:8527 P2RX2 HGNC:15459 P2RY12 HGNC:18124 P4HB HGNC:8548 PABPN1 HGNC:8565 PACS1 HGNC:30032 PAFAH1B1 HGNC:8574 PAH HGNC:8582 PAK3 HGNC:8592 PALB2 HGNC:26144 PAM16 HGNC:29679 PANK2 HGNC:15894 PAPSS2 HGNC:8604 PARK2 HGNC:8607 PARK7 HGNC:16369 PARN HGNC:8609 PARP1 HGNC:270 PAX1 HGNC:8615 PAX2 HGNC:8616 PAX3 HGNC:8617 PAX4 HGNC:8618 PAX5 HGNC:8619 PAX6 HGNC:8620 PAX7 HGNC:8621 PAX8 HGNC:8622 PAX9 HGNC:8623 PBX1 HGNC:8632 PCBD1 HGNC:8646 PCCA HGNC:8653 PCCB HGNC:8654 PCDH15 HGNC:14674

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article-authors endPage startPage article-title issue volume buildID journal-title copyright proof doi pub-date TABLE 4 Continued HGNC Gene Symbol HGNC:ID PCDH19 HGNC:14270 PCDHGA2 HGNC:8700 PC HGNC:8636 PCK1 HGNC:8724 PCK2 HGNC:8725 PCM1 HGNC:8727 PCNA HGNC:8729 PCNT HGNC:16068 PCSK1 HGNC:8743 PCSK9 HGNC:20001 PCYT1A HGNC:8754 PDCD10 HGNC:8761 PDE11A HGNC:8773 PDE3A HGNC:8778 PDE4D HGNC:8783 PDE6A HGNC:8785 PDE6B HGNC:8786 PDE6C HGNC:8787 PDE6D HGNC:8788 PDE6G HGNC:8789 PDE6H HGNC:8790 PDE8B HGNC:8794 PDGFB HGNC:8800 PDGFRA HGNC:8803 PDGFRB HGNC:8804 PDGFRL HGNC:8805 PDHA1 HGNC:8806 PDHB HGNC:8808 PDHX HGNC:21350 PDK3 HGNC:8811 PDP1 HGNC:9279 PDSS1 HGNC:17759 PDSS2 HGNC:23041 PDX1 HGNC:6107 PDYN HGNC:8820 PDZD7 HGNC:26257 PECR HGNC:18281 PEPD HGNC:8840 PER2 HGNC:8846 PET100 HGNC:40038 PEX10 HGNC:8851 PEX11B HGNC:8853 PEX12 HGNC:8854 PEX13 HGNC:8855 PEX14 HGNC:8856

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TABLE 4 Continued HGNC Gene Symbol HGNC:ID PEX16 HGNC:8857 PEX19 HGNC:9713 PEX1 HGNC:8850 PEX26 HGNC:22965 PEX2 HGNC:9717 PEX3 HGNC:8858 PEX5 HGNC:9719 PEX6 HGNC:8859 PEX7 HGNC:8860 PFKFB1 HGNC:8872 PFKM HGNC:8877 PFN1 HGNC:8881 PGAM2 HGNC:8889 PGAP1 HGNC:25712 PGAP2 HGNC:17893 PGAP3 HGNC:23719 PGK1 HGNC:8896 PGM1 HGNC:8905 PGM3 HGNC:8907 PGR HGNC:8910 PHACTR1 HGNC:20990 PHC1 HGNC:3182 PHEX HGNC:8918 PHF6 HGNC:18145 PHF8 HGNC:20672 PHGDH HGNC:8923 PHIP HGNC:15673 PHKA1 HGNC:8925 PHKA2 HGNC:8926 PHKB HGNC:8927 PHKG2 HGNC:8931 PHOX2A HGNC:691 PHOX2B HGNC:9143 PHYH HGNC:8940 PHYKPL HGNC:28249 PI4KA HGNC:8983 PICALM HGNC:15514 PIEZO1 HGNC:28993 PIEZO2 HGNC:26270 PIGA HGNC:8957 PIGL HGNC:8966 PIGM HGNC:18858 PIGN HGNC:8967 PIGO HGNC:23215 PIGV HGNC:26031

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article-authors endPage startPage article-title issue volume buildID journal-title copyright proof doi pub-date TABLE 4 Continued HGNC Gene Symbol HGNC:ID PIGW HGNC:23213 PIK3CA HGNC:8975 PIK3CD HGNC:8977 PIK3R1 HGNC:8979 PIK3R2 HGNC:8980 PIK3R5 HGNC:30035 PIKFYVE HGNC:23785 PINK1 HGNC:14581 PIP5K1C HGNC:8996 PITPNM3 HGNC:21043 PITX1 HGNC:9004 PITX2 HGNC:9005 PITX3 HGNC:9006 PKD1 HGNC:9008 PKD2 HGNC:9009 PKHD1 HGNC:9016 PKLR HGNC:9020 PKP1 HGNC:9023 PKP2 HGNC:9024 PLA2G4A HGNC:9035 PLA2G5 HGNC:9038 PLA2G6 HGNC:9039 PLA2G7 HGNC:9040 PLAG1 HGNC:9045 PLAGL1 HGNC:9046 PLAT HGNC:9051 PLAU HGNC:9052 PLCB1 HGNC:15917 PLCB4 HGNC:9059 PLCD1 HGNC:9060 PLCE1 HGNC:17175 PLCG2 HGNC:9066 PLCL2 HGNC:9064 PLEC HGNC:9069 PLEKHG4 HGNC:24501 PLEKHG5 HGNC:29105 PLEKHM1 HGNC:29017 PLG HGNC:9071 PLIN1 HGNC:9076 PLK1S1 HGNC:15865 PLK4 HGNC:11397 PLN HGNC:9080 PLOD1 HGNC:9081 PLOD2 HGNC:9082 PLOD3 HGNC:9083

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TABLE 4 Continued HGNC Gene Symbol HGNC:ID PLP1 HGNC:9086 PLS3 HGNC:9091 PMM2 HGNC:9115 PMP22 HGNC:9118 PMS2 HGNC:9122 PMVK HGNC:9141 PNKD HGNC:9153 PNKP HGNC:9154 PNLIP HGNC:9155 PNMT HGNC:9160 PNP HGNC:7892 PNPLA1 HGNC:21246 PNPLA2 HGNC:30802 PNPLA6 HGNC:16268 PNPLA8 HGNC:28900 PNPO HGNC:30260 PNPT1 HGNC:23166 POC1A HGNC:24488 POC1B HGNC:30836 POF1B HGNC:13711 POFUT1 HGNC:14988 POGLUT1 HGNC:22954 POGZ HGNC:18801 POLA1 HGNC:9173 POLD1 HGNC:9175 POLE HGNC:9177 POLG2 HGNC:9180 POLG HGNC:9179 POLH HGNC:9181 POLR1A HGNC:17264 POLR1C HGNC:20194 POLR1D HGNC:20422 POLR3A HGNC:30074 POLR3B HGNC:30348 POMC HGNC:9201 POMGNT1 HGNC:19139 POMGNT2 HGNC:25902 POMK HGNC:26267 POMP HGNC:20330 POMT1 HGNC:9202 POMT2 HGNC:19743 PON1 HGNC:9204 PORCN HGNC:17652 POR HGNC:9208 POT1 HGNC:17284

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article-authors endPage startPage article-title issue volume buildID journal-title copyright proof doi pub-date TABLE 4 Continued HGNC Gene Symbol HGNC:ID POU1F1 HGNC:9210 POU3F4 HGNC:9217 POU4F3 HGNC:9220 POU6F2 HGNC:21694 PPARG HGNC:9236 PPIB HGNC:9255 PPM1D HGNC:9277 PPM1K HGNC:25415 PPOX HGNC:9280 PPP1R3A HGNC:9291 PPP2R1A HGNC:9302 PPP2R1B HGNC:9303 PPP2R2B HGNC:9305 PPP2R5D HGNC:9312 PPT1 HGNC:9325 PQBP1 HGNC:9330 PRCC HGNC:9343 PRCD HGNC:32528 PRDM12 HGNC:13997 PRDM16 HGNC:14000 PRDM5 HGNC:9349 PRDM8 HGNC:13993 PRF1 HGNC:9360 PRG4 HGNC:9364 PRICKLE1 HGNC:17019 PRICKLE2 HGNC:20340 PRIMPOL HGNC:26575 PRKACA HGNC:9380 PRKACG HGNC:9382 PRKAG2 HGNC:9386 PRKAG3 HGNC:9387 PRKAR1A HGNC:9388 PRKCD HGNC:9399 PRKCG HGNC:9402 PRKCSH HGNC:9411 PRKDC HGNC:9413 PRKG1 HGNC:9414 PRKRA HGNC:9438 PRLR HGNC:9446 PRMT9 HGNC:25099 PRNP HGNC:9449 PROC HGNC:9451 PRODH HGNC:9453 PROK2 HGNC:18455 PROKR2 HGNC:15836

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TABLE 4 Continued HGNC Gene Symbol HGNC:ID PROM1 HGNC:9454 PROP1 HGNC:9455 PROS1 HGNC:9456 PROX2 HGNC:26715 PROZ HGNC:9460 PRPF31 HGNC:15446 PRPF3 HGNC:17348 PRPF4 HGNC:17349 PRPF6 HGNC:15860 PRPF8 HGNC:17340 PRPH2 HGNC:9942 PRPS1 HGNC:9462 PRPS2 HGNC:9465 PRRT2 HGNC:30500 PRRX1 HGNC:9142 PRSS12 HGNC:9477 PRSS1 HGNC:9475 PRSS56 HGNC:39433 PRX HGNC:13797 PSAP HGNC:9498 PSAT1 HGNC:19129 PSEN1 HGNC:9508 PSEN2 HGNC:9509 PSENEN HGNC:30100 PSMA7 HGNC:9536 PSMB8 HGNC:9545 PSMC3IP HGNC:17928 PSPH HGNC:9577 PSTPIP1 HGNC:9580 PTCH1 HGNC:9585 PTCH2 HGNC:9586 PTCHD1 HGNC:26392 PTDSS1 HGNC:9587 PTEN HGNC:9588 PTF1A HGNC:23734 PTGIS HGNC:9603 PTH1R HGNC:9608 PTH HGNC:9606 PTHLH HGNC:9607 PTPN11 HGNC:9644 PTPN14 HGNC:9647 PTPN2 HGNC:9650 PTPRC HGNC:9666 PTPRF HGNC:9670 PTPRJ HGNC:9673

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article-authors endPage startPage article-title issue volume buildID journal-title copyright proof doi pub-date TABLE 4 Continued HGNC Gene Symbol HGNC:ID PTPRO HGNC:9678 PTPRQ HGNC:9679 PTRF HGNC:9688 PTRH2 HGNC:24265 PTS HGNC:9689 PURA HGNC:9701 PUS1 HGNC:15508 PVRL1 HGNC:9706 PVRL4 HGNC:19688 PXDN HGNC:14966 PYCR1 HGNC:9721 PYCR2 HGNC:30262 PYGL HGNC:9725 PYGM HGNC:9726 QARS HGNC:9751 QDPR HGNC:9752 RAB18 HGNC:14244 RAB23 HGNC:14263 RAB27A HGNC:9766 RAB28 HGNC:9768 RAB33B HGNC:16075 RAB39B HGNC:16499 RAB3GAP1 HGNC:17063 RAB3GAP2 HGNC:17168 RAB40AL HGNC:25410 RAB7A HGNC:9788 RABL6 HGNC:24703 RAC2 HGNC:9802 RAD21 HGNC:9811 RAD50 HGNC:9816 RAD51C HGNC:9820 RAD51D HGNC:9823 RAD51 HGNC:9817 RAD54L HGNC:9826 RAF1 HGNC:9829 RAG1 HGNC:9831 RAG2 HGNC:9832 RAI1 HGNC:9834 RALGDS HGNC:9842 RANBP2 HGNC:9848 RAPGEF1 HGNC:4568 RAPSN HGNC:9863 RARA HGNC:9864 RARB HGNC:9865 RARS2 HGNC:21406

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TABLE 4 Continued HGNC Gene Symbol HGNC:ID RARS HGNC:9870 RASA1 HGNC:9871 RASGRP2 HGNC:9879 RASSF1 HGNC:9882 RAX2 HGNC:18286 RAX HGNC:18662 RB1CC1 HGNC:15574 RB1 HGNC:9884 RBBP8 HGNC:9891 RBCK1 HGNC:15864 RBM10 HGNC:9896 RBM20 HGNC:27424 RBM28 HGNC:21863 RBM8A HGNC:9905 RBP3 HGNC:9921 RBP4 HGNC:9922 RBPJ HGNC:5724 RD3 HGNC:19689 RDH11 HGNC:17964 RDH12 HGNC:19977 RDH5 HGNC:9940 RDX HGNC:9944 RECQL4 HGNC:9949 REEP1 HGNC:25786 REEP2 HGNC:17975 RELN HGNC:9957 REN HGNC:9958 RET HGNC:9967 RFT1 HGNC:30220 RFX5 HGNC:9986 RFX6 HGNC:21478 RFXANK HGNC:9987 RFXAP HGNC:9988 RGR HGNC:9990 RGS7 HGNC:10003 RGS9BP HGNC:30304 RGS9 HGNC:10004 RHAG HGNC:10006 RHBDF2 HGNC:20788 RHCE HGNC:10008 RHO HGNC:10012 RIMS1 HGNC:17282 RIN2 HGNC:18750 RIPK4 HGNC:496 RIPPLY2 HGNC:21390

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article-authors endPage startPage article-title issue volume buildID journal-title copyright proof doi pub-date TABLE 4 Continued HGNC Gene Symbol HGNC:ID RIT1 HGNC:10023 RLBP1 HGNC:10024 RLIM HGNC:13429 RMND1 HGNC:21176 RMRP HGNC:10031 RNASEH1 HGNC:18466 RNASEH2A HGNC:18518 RNASEH2B HGNC:25671 RNASEH2C HGNC:24116 RNASEL HGNC:10050 RNASET2 HGNC:21686 RNF113A HGNC:12974 RNF125 HGNC:21150 RNF135 HGNC:21158 RNF139 HGNC:17023 RNF168 HGNC:26661 RNF170 HGNC:25358 RNF212 HGNC:27729 RNF213 HGNC:14539 RNF216 HGNC:21698 RNF6 HGNC:10069 RNU4ATAC HGNC:34016 ROBO2 HGNC:10250 ROBO3 HGNC:13433 ROGDI HGNC:29478 ROM1 HGNC:10254 ROR2 HGNC:10257 RORC HGNC:10260 RP1 HGNC:10263 RP1L1 HGNC:15946 RP2 HGNC:10274 RP9 HGNC:10288 RPE65 HGNC:10294 RPGR HGNC:10295 RPGRIP1 HGNC:13436 RPGRIP1L HGNC:29168 RPIA HGNC:10297 RPL10 HGNC:10298 RPL11 HGNC:10301 RPL15 HGNC:10306 RPL21 HGNC:10313 RPL26 HGNC:10327 RPL35A HGNC:10345 RPL5 HGNC:10360 RPS10 HGNC:10383

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TABLE 4 Continued HGNC Gene Symbol HGNC:ID RPS14 HGNC:10387 RPS17 HGNC:10397 RPS19 HGNC:10402 RPS24 HGNC:10411 RPS26 HGNC:10414 RPS28 HGNC:10418 RPS29 HGNC:10419 RPS4X HGNC:10424 RPS6KA3 HGNC:10432 RPS7 HGNC:10440 RPSA HGNC:6502 RRM2B HGNC:17296 RS1 HGNC:10457 RSPH1 HGNC:12371 RSPH3 HGNC:21054 RSPH4A HGNC:21558 RSPH9 HGNC:21057 RSPO1 HGNC:21679 RSPO4 HGNC:16175 RTEL1 HGNC:15888 RTN2 HGNC:10468 RTTN HGNC:18654 RUNX1 HGNC:10471 RUNX2 HGNC:10472 RXFP2 HGNC:17318 RYR1 HGNC:10483 RYR2 HGNC:10484 SACS HGNC:10519 SAG HGNC:10521 SALL1 HGNC:10524 SALL2 HGNC:10526 SALL4 HGNC:15924 SAMD9 HGNC:1348 SAMHD1 HGNC:15925 SAR1B HGNC:10535 SARS2 HGNC:17697 SART3 HGNC:16860 SASS6 HGNC:25403 SAT1 HGNC:10540 SATB2 HGNC:21637 SBDS HGNC:19440 SBF1 HGNC:10542 SBF2 HGNC:2135 SC5D HGNC:10547 SCAPER HGNC:13081

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article-authors endPage startPage article-title issue volume buildID journal-title copyright proof doi pub-date TABLE 4 Continued HGNC Gene Symbol HGNC:ID SCARB2 HGNC:1665 SCARF2 HGNC:19869 SCN11A HGNC:10583 SCN1A HGNC:10585 SCN1B HGNC:10586 SCN2A HGNC:10588 SCN2B HGNC:10589 SCN3B HGNC:20665 SCN4A HGNC:10591 SCN4B HGNC:10592 SCN5A HGNC:10593 SCN8A HGNC:10596 SCN9A HGNC:10597 SCNN1A HGNC:10599 SCNN1B HGNC:10600 SCNN1G HGNC:10602 SCO1 HGNC:10603 SCO2 HGNC:10604 SCP2 HGNC:10606 SDCCAG8 HGNC:10671 SDHAF1 HGNC:33867 SDHAF2 HGNC:26034 SDHA HGNC:10680 SDHB HGNC:10681 SDHC HGNC:10682 SDHD HGNC:10683 SEC23A HGNC:10701 SEC23B HGNC:10702 SEC63 HGNC:21082 SECISBP2 HGNC:30972 SEMA3A HGNC:10723 SEMA3E HGNC:10727 SEMA4A HGNC:10729 SEMA7A HGNC:10741 SEPN1 HGNC:15999 SEPSECS HGNC:30605 SEPT12 HGNC:26348 SEPT9 HGNC:7323 SERAC1 HGNC:21061 SERPINA1 HGNC:8941 SERPINA6 HGNC:1540 SERPINA7 HGNC:11583 SERPINB6 HGNC:8950 SERPINB7 HGNC:13902 SERPINC1 HGNC:775

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TABLE 4 Continued HGNC Gene Symbol HGNC:ID SERPIND1 HGNC:4838 SERPINE1 HGNC:8583 SERPINF1 HGNC:8824 SERPINF2 HGNC:9075 SERPING1 HGNC:1228 SERPINH1 HGNC:1546 SERPINI1 HGNC:8943 SETBP1 HGNC:15573 SETD5 HGNC:25566 SETX HGNC:445 SF3B1 HGNC:10768 SF3B4 HGNC:10771 SFTPA1 HGNC:10798 SFTPA2 HGNC:10799 SFTPB HGNC:10801 SFTPC HGNC:10802 SFXN4 HGNC:16088 SGCA HGNC:10805 SGCB HGNC:10806 SGCD HGNC:10807 SGCE HGNC:10808 SGCG HGNC:10809 SGSH HGNC:10818 SH2B3 HGNC:29605 SH2D1A HGNC:10820 SH3BP2 HGNC:10825 SH3GL1 HGNC:10830 SH3PXD2B HGNC:29242 SH3TC2 HGNC:29427 SHANK2 HGNC:14295 SHANK3 HGNC:14294 SHFM1 HGNC:10845 SHH HGNC:10848 SHOC2 HGNC:15454 SHOX HGNC:10853 SHROOM4 HGNC:29215 SIGMAR1 HGNC:8157 SI HGNC:10856 SIK1 HGNC:11142 SIL1 HGNC:24624 SIM1 HGNC:10882 SIX1 HGNC:10887 SIX3 HGNC:10889 SIX5 HGNC:10891 SIX6 HGNC:10892

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article-authors endPage startPage article-title issue volume buildID journal-title copyright proof doi pub-date TABLE 4 Continued HGNC Gene Symbol HGNC:ID SKI HGNC:10896 SKIV2L HGNC:10898 SLC10A2 HGNC:10906 SLC10A3 HGNC:22979 SLC11A2 HGNC:10908 SLC12A1 HGNC:10910 SLC12A3 HGNC:10912 SLC12A5 HGNC:13818 SLC12A6 HGNC:10914 SLC13A5 HGNC:23089 SLC14A1 HGNC:10918 SLC16A12 HGNC:23094 SLC16A1 HGNC:10922 SLC16A2 HGNC:10923 SLC17A5 HGNC:10933 SLC17A8 HGNC:20151 SLC17A9 HGNC:16192 SLC19A2 HGNC:10938 SLC19A3 HGNC:16266 SLC1A1 HGNC:10939 SLC1A3 HGNC:10941 SLC20A2 HGNC:10947 SLC22A12 HGNC:17989 SLC22A18 HGNC:10964 SLC22A5 HGNC:10969 SLC24A1 HGNC:10975 SLC24A4 HGNC:10978 SLC25A12 HGNC:10982 SLC25A13 HGNC:10983 SLC25A15 HGNC:10985 SLC25A19 HGNC:14409 SLC25A1 HGNC:10979 SLC25A20 HGNC:1421 SLC25A22 HGNC:19954 SLC25A38 HGNC:26054 SLC25A3 HGNC:10989 SLC25A46 HGNC:25198 SLC25A4 HGNC:10990 SLC26A2 HGNC:10994 SLC26A3 HGNC:3018 SLC26A4 HGNC:8818 SLC26A5 HGNC:9359 SLC26A8 HGNC:14468 SLC27A4 HGNC:10998 SLC29A3 HGNC:23096

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TABLE 4 Continued HGNC Gene Symbol HGNC:ID SLC2A10 HGNC:13444 SLC2A1 HGNC:11005 SLC2A2 HGNC:11006 SLC2A9 HGNC:13446 SLC30A10 HGNC:25355 SLC30A2 HGNC:11013 SLC31A1 HGNC:11016 SLC33A1 HGNC:95 SLC34A1 HGNC:11019 SLC34A2 HGNC:11020 SLC34A3 HGNC:20305 SLC35A1 HGNC:11021 SLC35A2 HGNC:11022 SLC35A3 HGNC:11023 SLC35C1 HGNC:20197 SLC35D1 HGNC:20800 SLC36A2 HGNC:18762 SLC37A4 HGNC:4061 SLC38A8 HGNC:32434 SLC39A13 HGNC:20859 SLC39A4 HGNC:17129 SLC39A5 HGNC:20502 SLC3A1 HGNC:11025 SLC40A1 HGNC:10909 SLC41A1 HGNC:19429 SLC45A2 HGNC:16472 SLC46A1 HGNC:30521 SLC4A11 HGNC:16438 SLC4A1 HGNC:11027 SLC4A4 HGNC:11030 SLC52A1 HGNC:30225 SLC52A2 HGNC:30224 SLC52A3 HGNC:16187 SLC5A1 HGNC:11036 SLC5A2 HGNC:11037 SLC5A5 HGNC:11040 SLC5A7 HGNC:14025 SLC6A17 HGNC:31399 SLC6A19 HGNC:27960 SLC6A1 HGNC:11042 SLC6A20 HGNC:30927 SLC6A2 HGNC:11048 SLC6A3 HGNC:11049 SLC6A5 HGNC:11051 SLC6A8 HGNC:11055

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article-authors endPage startPage article-title issue volume buildID journal-title copyright proof doi pub-date TABLE 4 Continued HGNC Gene Symbol HGNC:ID SLC7A14 HGNC:29326 SLC7A7 HGNC:11065 SLC7A9 HGNC:11067 SLC9A1 HGNC:11071 SLC9A3R1 HGNC:11075 SLC9A6 HGNC:11079 SLC9A9 HGNC:20653 SLCO1B1 HGNC:10959 SLCO1B3 HGNC:10961 SLCO2A1 HGNC:10955 SLITRK1 HGNC:20297 SLITRK6 HGNC:23503 SLURP1 HGNC:18746 SLX4 HGNC:23845 SMAD3 HGNC:6769 SMAD4 HGNC:6770 SMAD6 HGNC:6772 SMAD9 HGNC:6774 SMARCA2 HGNC:11098 SMARCA4 HGNC:11100 SMARCAD1 HGNC:18398 SMARCAL1 HGNC:11102 SMARCB1 HGNC:11103 SMARCE1 HGNC:11109 SMC1A HGNC:11111 SMC3 HGNC:2468 SMCHD1 HGNC:29090 SMIM1 HGNC:44204 SMN1 HGNC:11117 SMN2 HGNC:11118 SMOC1 HGNC:20318 SMOC2 HGNC:20323 SMPD1 HGNC:11120 SMPX HGNC:11122 SMS HGNC:11123 SNAI2 HGNC:11094 SNAP25 HGNC:11132 SNAP29 HGNC:11133 SNCA HGNC:11138 SNCAIP HGNC:11139 SNCB HGNC:11140 SNIP1 HGNC:30587 SNRNP200 HGNC:30859 SNRPE HGNC:11161 SNRPN HGNC:11164

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TABLE 4 Continued HGNC Gene Symbol HGNC:ID SNTA1 HGNC:11167 SNX10 HGNC:14974 SNX14 HGNC:14977 SOBP HGNC:29256 SOD1 HGNC:11179 SOS1 HGNC:11187 SOS2 HGNC:11188 SOST HGNC:13771 SOX10 HGNC:11190 SOX11 HGNC:11191 SOX17 HGNC:18122 SOX18 HGNC:11194 SOX2 HGNC:11195 SOX3 HGNC:11199 SOX9 HGNC:11204 SP110 HGNC:5401 SP7 HGNC:17321 SPARC HGNC:11219 SPAST HGNC:11233 SPATA16 HGNC:29935 SPATA5 HGNC:18119 SPATA7 HGNC:20423 SPECC1L HGNC:29022 SPEG HGNC:16901 SPG11 HGNC:11226 SPG20 HGNC:18514 SPG21 HGNC:20373 SPG7 HGNC:11237 SPINK1 HGNC:11244 SPINK5 HGNC:15464 SPINT2 HGNC:11247 SPRED1 HGNC:20249 SPR HGNC:11257 SPRY4 HGNC:15533 SPTA1 HGNC:11272 SPTAN1 HGNC:11273 SPTB HGNC:11274 SPTBN2 HGNC:11276 SPTLC1 HGNC:11277 SPTLC2 HGNC:11278 SQSTM1 HGNC:11280 SRCAP HGNC:16974 SRD5A2 HGNC:11285 SRD5A3 HGNC:25812 SRP72 HGNC:11303

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article-authors endPage startPage article-title issue volume buildID journal-title copyright proof doi pub-date TABLE 4 Continued HGNC Gene Symbol HGNC:ID SRPX2 HGNC:30668 SRY HGNC:11311 SSR4 HGNC:11326 SSTR5 HGNC:11334 ST14 HGNC:11344 ST3GAL3 HGNC:10866 ST3GAL5 HGNC:10872 STAG1 HGNC:11354 STAG3 HGNC:11356 STAMBP HGNC:16950 STAR HGNC:11359 STAT1 HGNC:11362 STAT3 HGNC:11364 STAT5B HGNC:11367 STEAP3 HGNC:24592 STIL HGNC:10879 STIM1 HGNC:11386 STK11 HGNC:11389 STK4 HGNC:11408 STOM HGNC:3383 STOX1 HGNC:23508 STRA6 HGNC:30650 STRADA HGNC:30172 STRC HGNC:16035 STS HGNC:11425 STT3A HGNC:6172 STT3B HGNC:30611 STUB1 HGNC:11427 STX11 HGNC:11429 STX16 HGNC:11431 STX1B HGNC:18539 STXBP1 HGNC:11444 STXBP2 HGNC:11445 SUCLA2 HGNC:11448 SUCLG1 HGNC:11449 SUFU HGNC:16466 SUGCT HGNC:16001 SUMF1 HGNC:20376 SUMO1 HGNC:12502 SUOX HGNC:11460 SURF1 HGNC:11474 SYCP3 HGNC:18130 SYN1 HGNC:11494 SYNCRIP HGNC:16918 SYNE1 HGNC:17089

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TABLE 4 Continued HGNC Gene Symbol HGNC:ID SYNE2 HGNC:17084 SYNE4 HGNC:26703 SYNGAP1 HGNC:11497 SYP HGNC:11506 SYT14 HGNC:23143 SYT2 HGNC:11510 SZT2 HGNC:29040 TAB2 HGNC:17075 TAC3 HGNC:11521 TACO1 HGNC:24316 TACR3 HGNC:11528 TACSTD2 HGNC:11530 TAF15 HGNC:11547 TAF1 HGNC:11535 TAF2 HGNC:11536 TAF4B HGNC:11538 TAF7L HGNC:11548 TAL1 HGNC:11556 TALDO1 HGNC:11559 TANC2 HGNC:30212 TAP1 HGNC:43 TAP2 HGNC:44 TAPBP HGNC:11566 TARDBP HGNC:11571 TARS2 HGNC:30740 TAS2R38 HGNC:9584 TAT HGNC:11573 TAZ HGNC:11577 TBC1D20 HGNC:16133 TBC1D24 HGNC:29203 TBC1D4 HGNC:19165 TBC1D7 HGNC:21066 TBCE HGNC:11582 TBK1 HGNC:11584 TBP HGNC:11588 TBX15 HGNC:11594 TBX18 HGNC:11595 TBX19 HGNC:11596 TBX1 HGNC:11592 TBX20 HGNC:11598 TBX21 HGNC:11599 TBX22 HGNC:11600 TBX3 HGNC:11602 TBX4 HGNC:11603 TBX5 HGNC:11604

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article-authors endPage startPage article-title issue volume buildID journal-title copyright proof doi pub-date TABLE 4 Continued HGNC Gene Symbol HGNC:ID TBX6 HGNC:11605 TBXA2R HGNC:11608 TBXAS1 HGNC:11609 TCAP HGNC:11610 TCF12 HGNC:11623 TCF4 HGNC:11634 TCIRG1 HGNC:11647 TCL1A HGNC:11648 TCN2 HGNC:11653 TCOF1 HGNC:11654 TCTN1 HGNC:26113 TCTN2 HGNC:25774 TCTN3 HGNC:24519 TDGF1 HGNC:11701 TDP1 HGNC:18884 TDRD7 HGNC:30831 TEAD1 HGNC:11714 TECPR2 HGNC:19957 TECR HGNC:4551 TECTA HGNC:11720 TEK HGNC:11724 TENM1 HGNC:8117 TENM3 HGNC:29944 TERC HGNC:11727 TERT HGNC:11730 TET2 HGNC:25941 TEX11 HGNC:11733 TFAP2A HGNC:11742 TFAP2B HGNC:11743 TFE3 HGNC:11752 TFG HGNC:11758 TF HGNC:11740 TFR2 HGNC:11762 TGDS HGNC:20324 TGFB1 HGNC:11766 TGFB2 HGNC:11768 TGFB3 HGNC:11769 TGFBI HGNC:11771 TGFBR1 HGNC:11772 TGFBR2 HGNC:11773 TG HGNC:11764 TGIF1 HGNC:11776 TGM1 HGNC:11777 TGM5 HGNC:11781 TGM6 HGNC:16255

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TABLE 4 Continued HGNC Gene Symbol HGNC:ID THAP1 HGNC:20856 THBD HGNC:11784 T HGNC:11515 TH HGNC:11782 THOC2 HGNC:19073 THPO HGNC:11795 THRA HGNC:11796 THRB HGNC:11799 TIA1 HGNC:11802 TICAM1 HGNC:18348 TIMM8A HGNC:11817 TIMP3 HGNC:11822 TINF2 HGNC:11824 TJP2 HGNC:11828 TK2 HGNC:11831 TLL1 HGNC:11843 TLR3 HGNC:11849 TMC1 HGNC:16513 TMC6 HGNC:18021 TMC8 HGNC:20474 TMCO1 HGNC:18188 TMEM114 HGNC:33227 TMEM126A HGNC:25382 TMEM127 HGNC:26038 TMEM135 HGNC:26167 TMEM138 HGNC:26944 TMEM165 HGNC:30760 TMEM173 HGNC:27962 TMEM216 HGNC:25018 TMEM231 HGNC:37234 TMEM237 HGNC:14432 TMEM240 HGNC:25186 TMEM38B HGNC:25535 TMEM43 HGNC:28472 TMEM5 HGNC:13530 TMEM67 HGNC:28396 TMEM70 HGNC:26050 TMEM98 HGNC:24529 TMIE HGNC:30800 TMLHE HGNC:18308 TMPO HGNC:11875 TMPRSS15 HGNC:9490 TMPRSS3 HGNC:11877 TMPRSS6 HGNC:16517

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article-authors endPage startPage article-title issue volume buildID journal-title copyright proof doi pub-date TABLE 4 Continued HGNC Gene Symbol HGNC:ID TNC HGNC:5318 TNF HGNC:11892 TNFRSF10B HGNC:11905 TNFRSF11A HGNC:11908 TNFRSF11B HGNC:11909 TNFRSF13B HGNC:18153 TNFRSF13C HGNC:17755 TNFRSF1A HGNC:11916 TNFRSF4 HGNC:11918 TNFSF11 HGNC:11926 TNNC1 HGNC:11943 TNNI2 HGNC:11946 TNNI3 HGNC:11947 TNNI3K HGNC:19661 TNNT1 HGNC:11948 TNNT2 HGNC:11949 TNNT3 HGNC:11950 TNPO2 HGNC:19998 TNPO3 HGNC:17103 TNXB HGNC:11976 TOPORS HGNC:21653 TOR1A HGNC:3098 TP53 HGNC:11998 TP63 HGNC:15979 TPCN2 HGNC:20820 TPI1 HGNC:12009 TPK1 HGNC:17358 TPM1 HGNC:12010 TPM2 HGNC:12011 TPM3 HGNC:12012 TPMT HGNC:12014 TPO HGNC:12015 TPP1 HGNC:2073 TPRN HGNC:26894 TRAC HGNC:12029 TRAF3 HGNC:12033 TRAF3IP1 HGNC:17861 TRAF3IP2 HGNC:1343 TRAP1 HGNC:16264 TRAPPC11 HGNC:25751 TRAPPC2 HGNC:23068 TRAPPC9 HGNC:30832 TRDN HGNC:12261 TREH HGNC:12266 TREM2 HGNC:17761

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TABLE 4 Continued HGNC Gene Symbol HGNC:ID TREX1 HGNC:12269 TRH HGNC:12298 TRHR HGNC:12299 TRIM24 HGNC:11812 TRIM2 HGNC:15974 TRIM32 HGNC:16380 TRIM33 HGNC:16290 TRIM37 HGNC:7523 TRIOBP HGNC:17009 TRIO HGNC:12303 TRIP11 HGNC:12305 TRMT10A HGNC:28403 TRMT1 HGNC:25980 TRMT5 HGNC:23141 TRMU HGNC:25481 TRNT1 HGNC:17341 TRPA1 HGNC:497 TRPC3 HGNC:12335 TRPC6 HGNC:12338 TRPM1 HGNC:7146 TRPM4 HGNC:17993 TRPM6 HGNC:17995 TRPS1 HGNC:12340 TRPV3 HGNC:18084 TRPV4 HGNC:18083 TRRAP HGNC:12347 TSC1 HGNC:12362 TSC2 HGNC:12363 TSEN2 HGNC:28422 TSEN34 HGNC:15506 TSEN54 HGNC:27561 TSFM HGNC:12367 TSG101 HGNC:15971 TSHB HGNC:12372 TSHR HGNC:12373 TSHZ1 HGNC:10669 TSPAN12 HGNC:21641 TSPAN7 HGNC:11854 TSPEAR HGNC:1268 TSPYL1 HGNC:12382 TSR2 HGNC:25455 TTBK2 HGNC:19141 TTC19 HGNC:26006 TTC21B HGNC:25660 TTC37 HGNC:23639

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article-authors endPage startPage article-title issue volume buildID journal-title copyright proof doi pub-date TABLE 4 Continued HGNC Gene Symbol HGNC:ID TTC7A HGNC:19750 TTC8 HGNC:20087 TTI2 HGNC:26262 TTLL5 HGNC:19963 TTN HGNC:12403 TTPA HGNC:12404 TTR HGNC:12405 TUBA1A HGNC:20766 TUBA4A HGNC:12407 TUBA8 HGNC:12410 TUBB1 HGNC:16257 TUBB2A HGNC:12412 TUBB2B HGNC:30829 TUBB3 HGNC:20772 TUBB4A HGNC:20774 TUBB HGNC:20778 TUBG1 HGNC:12417 TUBGCP4 HGNC:16691 TUBGCP6 HGNC:18127 TUB HGNC:12406 TUFM HGNC:12420 TULP1 HGNC:12423 TUSC3 HGNC:30242 TWIST1 HGNC:12428 TWIST2 HGNC:20670 TXNL4A HGNC:30551 TXNRD2 HGNC:18155 TYK2 HGNC:12440 TYMP HGNC:3148 TYR HGNC:12442 TYROBP HGNC:12449 TYRP1 HGNC:12450 UBA1 HGNC:12469 UBB HGNC:12463 UBE2A HGNC:12472 UBE2T HGNC:25009 UBE3A HGNC:12496 UBE3B HGNC:13478 UBIAD1 HGNC:30791 UBQLN2 HGNC:12509 UBR1 HGNC:16808 UBR7 HGNC:20344 UCHL1 HGNC:12513 UFD1L HGNC:12520 UFSP2 HGNC:25640

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TABLE 4 Continued HGNC Gene Symbol HGNC:ID UGT1A1 HGNC:12530 UMOD HGNC:12559 UMPS HGNC:12563 UNC119 HGNC:12565 UNC13D HGNC:23147 UNC45B HGNC:14304 UNC93B1 HGNC:13481 UNG HGNC:12572 UPB1 HGNC:16297 UPF3B HGNC:20439 UPK3A HGNC:12580 UQCC2 HGNC:21237 UQCRB HGNC:12582 UQCRC2 HGNC:12586 UQCRQ HGNC:29594 UROC1 HGNC:26444 UROD HGNC:12591 UROS HGNC:12592 USB1 HGNC:25792 USH1C HGNC:12597 USH1G HGNC:16356 USH2A HGNC:12601 USP9X HGNC:12632 USP9Y HGNC:12633 UVSSA HGNC:29304 VAMP1 HGNC:12642 VANGL1 HGNC:15512 VANGL2 HGNC:15511 VAPB HGNC:12649 VARS2 HGNC:21642 VAX1 HGNC:12660 VCAN HGNC:2464 VCL HGNC:12665 VCP HGNC:12666 VDR HGNC:12679 VEGFC HGNC:12682 VHL HGNC:12687 VIM HGNC:12692 VIPAS39 HGNC:20347 VKORC1 HGNC:23663 VLDLR HGNC:12698 VMA21 HGNC:22082 VPS13A HGNC:1908 VPS13B HGNC:2183 VPS33B HGNC:12712

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article-authors endPage startPage article-title issue volume buildID journal-title copyright proof doi pub-date TABLE 4 Continued HGNC Gene Symbol HGNC:ID VPS35 HGNC:13487 VPS37A HGNC:24928 VPS39 HGNC:20593 VPS45 HGNC:14579 VPS53 HGNC:25608 VRK1 HGNC:12718 VSX1 HGNC:12723 VSX2 HGNC:1975 VWF HGNC:12726 WAC HGNC:17327 WAS HGNC:12731 WDPCP HGNC:28027 WDR11 HGNC:13831 WDR19 HGNC:18340 WDR34 HGNC:28296 WDR35 HGNC:29250 WDR36 HGNC:30696 WDR45B HGNC:25072 WDR45 HGNC:28912 WDR60 HGNC:21862 WDR62 HGNC:24502 WDR65 HGNC:26485 WDR72 HGNC:26790 WDR73 HGNC:25928 WDR81 HGNC:26600 WFS1 HGNC:12762 WHSC1 HGNC:12766 WHSC1L1 HGNC:12767 WIPF1 HGNC:12736 WISP3 HGNC:12771 WNK1 HGNC:14540 WNK4 HGNC:14544 WNT10A HGNC:13829 WNT10B HGNC:12775 WNT1 HGNC:12774 WNT3 HGNC:12782 WNT4 HGNC:12783 WNT5A HGNC:12784 WNT7A HGNC:12786 WRAP53 HGNC:25522 WRN HGNC:12791 WT1 HGNC:12796 WWOX HGNC:12799 XDH HGNC:12805 XG HGNC:12806

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TABLE 4 Continued HGNC Gene Symbol HGNC:ID XIAP HGNC:592 XIST HGNC:12810 XK HGNC:12811 XPA HGNC:12814 XPC HGNC:12816 XPNPEP2 HGNC:12823 XPNPEP3 HGNC:28052 XPR1 HGNC:12827 XRCC4 HGNC:12831 XYLT1 HGNC:15516 YAP1 HGNC:16262 YARS2 HGNC:24249 YARS HGNC:12840 ZAP70 HGNC:12858 ZBTB16 HGNC:12930 ZBTB18 HGNC:13030 ZBTB20 HGNC:13503 ZBTB24 HGNC:21143 ZBTB40 HGNC:29045 ZBTB42 HGNC:32550 ZC4H2 HGNC:24931 ZCCHC12 HGNC:27273 ZCCHC8 HGNC:25265 ZDHHC15 HGNC:20342 ZDHHC9 HGNC:18475 ZEB1 HGNC:11642 ZEB2 HGNC:14881 ZFHX4 HGNC:30939 ZFP57 HGNC:18791 ZFPM2 HGNC:16700 ZFX HGNC:12869 ZFYVE26 HGNC:20761 ZFYVE27 HGNC:26559 ZIC1 HGNC:12872 ZIC2 HGNC:12873 ZIC3 HGNC:12874 ZIM2 HGNC:12875 ZMPSTE24 HGNC:12877 ZMYM3 HGNC:13054 ZMYND10 HGNC:19412 ZMYND11 HGNC:16966 ZMYND15 HGNC:20997 ZNF141 HGNC:12926 ZNF335 HGNC:15807 ZNF408 HGNC:20041

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article-authors endPage startPage article-title issue volume buildID journal-title copyright proof doi pub-date TABLE 4 Continued HGNC Gene Symbol HGNC:ID ZNF41 HGNC:13107 ZNF423 HGNC:16762 ZNF469 HGNC:23216 ZNF480 HGNC:23305 ZNF513 HGNC:26498 ZNF526 HGNC:29415 ZNF565 HGNC:26726 ZNF592 HGNC:28986 ZNF644 HGNC:29222 ZNF674 HGNC:17625 ZNF711 HGNC:13128 ZNF750 HGNC:25843 ZNF81 HGNC:13156 ZP1 HGNC:13187 ZSWIM6 HGNC:29316 HGNC, HUGO Committee.

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