Supplementary Table 2: Infection-Sensitive Genes

Home , AP2B1, AQP5, BCKDHA, BCKDHB, COX8A, Glutathione hydrolase

Supplementary Table 2: Upregulated with Adenoviral Infection (pages 1 - 7)- genes that were significant by ANOVA as well as significantly increased in control compared to both 'infected control' (Ad-LacZ) and 'calcineurin infected' (Ad-aCaN). Downregulated with Adenoviral Infection (pages 7 - 13) as above except for direction of change. Columns: Probe Set- Affymetrix probe set identifier for RG-U34A microarray, Symbol and Title- annotated information for above probe set (annotation downloaded June, 2004), ANOVA- p-value for 1-way Analysis of Variance, Uninfected, Ad-LacZ and Ad- aCaN- mean ± SEM expression for uninfected control, adenovirus mediated LacZ treated control, and adenovirus mediated calcineurin treated cultures respectively.

Upregulated with Adenoviral Infection Probe Set Symbol Title ANOVA Uninfected Ad-LacZ Ad-aCaN Z48444cds_at Adam10 a disintegrin and metalloprotease domain 10 0.00001 837 ± 31 1107 ± 24 1028 ± 29 L26986_at Adcy8 adenylyl cyclase 8 0.00028 146 ± 12 252 ± 21 272 ± 21 U94340_at Adprt ADP-ribosyltransferase 1 0.00695 2096 ± 100 2783 ± 177 2586 ± 118 U01914_at Akap8 A kinase anchor protein 8 0.00080 993 ± 44 1194 ± 65 1316 ± 44 AB008538_at Alcam activated leukocyte cell adhesion molecule 0.01012 2775 ± 136 3580 ± 216 3429 ± 155 M34176_s_at Ap2b1 adaptor-related protein complex 2, beta 1 subunit 0.01389 2408 ± 199 2947 ± 143 3071 ± 116 D44495_s_at Apex1 apurinic/apyrimidinic endonuclease 1 0.00089 4959 ± 185 5816 ± 202 6057 ± 158 U16245_at Aqp5 aquaporin 5 0.02710 168 ± 6 214 ± 9 216 ± 17 L12383_at Arf4 ADP-ribosylation factor 4 0.00001 8634 ± 125 10596 ± 121 10465 ± 291 rc_AA944324_at Arf6 ADP-ribosylation factor 6 0.00000 3016 ± 122 4546 ± 203 4164 ± 123 U90887_at Arg2 arginase 2 0.00000 415 ± 25 891 ± 42 907 ± 34 AF017756_at Axin GSK-3beta interacting protein rAxin 0.00003 965 ± 51 1352 ± 53 1372 ± 52 M75168_at Bat1a HLA-B-associated transcript 1A 0.00331 2403 ± 131 3116 ± 82 3016 ± 157 rc_AA892014_s_at Bat1a HLA-B-associated transcript 1A 0.00000 5108 ± 198 8177 ± 483 7792 ± 149 rc_AI010293_at Bat3 HLA-B-associated transcript 3 0.00000 2198 ± 63 3271 ± 109 2981 ± 82 L26268_at Btg1 B-cell translocation gene 1 0.00059 3958 ± 229 4921 ± 121 5280 ± 224 L02315_at Cacnb4 calcium channel beta 4 subunit 0.00095 231 ± 17 310 ± 8 304 ± 14 L27487_at Calcrl calcitonin receptor-like 0.01445 147 ± 13 202 ± 18 215 ± 15 U53859_at Capns1 calpain, small subunit 1 0.02169 5700 ± 343 6902 ± 213 6675 ± 280 U77933_at Casp2 caspase 2 0.00000 1085 ± 37 1749 ± 98 1969 ± 78 U49930_g_at Casp3 caspase 3 0.00004 1276 ± 59 1589 ± 60 1730 ± 49 AF087437UTR#1_s_at Cbfb core binding factor beta 0.00002 4776 ± 306 6158 ± 235 6601 ± 97 L11007_at Cdk4 cyclin-dependent kinase 4 0.00004 4838 ± 135 6305 ± 330 6599 ± 173 X83579_at Cdk7 cyclin-dependent kinase 7 0.00015 599 ± 35 838 ± 46 903 ± 43 U11031_at Cntn3 contactin 3 0.00012 128 ± 22 230 ± 29 278 ± 9 X95466_at CPG2 CPG2 protein 0.00266 242 ± 18 381 ± 34 349 ± 20 X14788_s_at Creb1 cAMP response element binding protein 1 0.01655 514 ± 31 694 ± 44 680 ± 47 L15618_at Csnk2a1 casein kinase II, alpha 1 polypeptide 0.00156 772 ± 75 1096 ± 71 1124 ± 50 rc_AI230260_s_at Csnk2b casein kinase II beta subunit 0.00018 5811 ± 279 8088 ± 232 7203 ± 334 U44948_at Csrp2 cysteine rich protein 2 0.00014 1332 ± 56 1703 ± 68 1785 ± 63 U17035_s_at Cxcl10 chemokine (C-X-C motif) ligand 10 0.00007 149 ± 8 722 ± 106 637 ± 72 D83948mRNA_at D83948 RNA binding motif protein 10 0.00844 1111 ± 56 1359 ± 25 1315 ± 59 AF039583_s_at Daf decay-accelarating factor 0.00021 148 ± 28 302 ± 28 347 ± 29 X62160_at Dctn1 dynactin 1 0.00504 7885 ± 432 9401 ± 282 8979 ± 130

Page 1 Supplementary Table 2: Infection-Sensitive Genes

Probe Set Symbol Title ANOVA Uninfected Ad-LacZ Ad-aCaN U30186_at Ddit3 DNA-damage inducible transcript 3 0.00006 1050 ± 71 1447 ± 52 1534 ± 62 AF063447_at Ddxl nuclear RNA helicase, DECD variant of DEAD box family 0.00000 1183 ± 89 2338 ± 201 2304 ± 44 D31734_g_at Dlx5 Distal-less homeobox 0.00037 439 ± 11 600 ± 53 641 ± 17 U15138_at Dncli2 LIC-2 dynein light intermediate chain 53/55 0.00273 12227 ± 687 13992 ± 400 15038 ± 413 AB012214_s_at Dnmt1 DNA (cytosine-5-)-methyltransferase 1 0.00005 1431 ± 42 2128 ± 99 1975 ± 95 U31777_g_at Drpla dentatorubral pallidoluysian atrophy 0.00447 2057 ± 371 3297 ± 119 2890 ± 143 L05489_at Dtr diphtheria toxin receptor 0.00000 477 ± 37 717 ± 24 796 ± 22 rc_AI104012_at Dyrk1a dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.00002 475 ± 31 634 ± 22 713 ± 28 Y16188_at Ecel1 endothelin converting enzyme-like 1 0.00305 311 ± 26 459 ± 32 412 ± 21 K01677_at Eif5 eukaryotic initiation factor 5 (eIF-5) 0.00433 535 ± 32 728 ± 58 725 ± 30 M19651_at Fosl1 Fos-like antigen 1 0.01169 38 ± 4 195 ± 69 236 ± 36 U09583_at Frk src related tyrosine kinase 0.00771 24 ± 4 48 ± 3 44 ± 6 rc_AA858520_g_at Fst follistatin 0.00004 190 ± 12 300 ± 10 356 ± 27 AF058791_at G10 maternal G10 transcript 0.00008 2406 ± 91 3085 ± 94 3130 ± 108 X15467cds_at Gabrb2 Gamma-aminobutyric acid receptor beta 2 0.01864 257 ± 24 375 ± 23 374 ± 35 M80367_at Gbp2 guanylate binding protein 2, interferon-inducible 0.00009 90 ± 17 463 ± 79 428 ± 42 rc_AA891829_g_at Gch GTP cyclohydrolase 1 0.00033 1185 ± 109 1714 ± 69 1572 ± 47 AF087431_g_at Gcs1 glucosidase 1 0.00060 2139 ± 112 2859 ± 152 2604 ± 53 rc_AI228247_at Gnai3 Guanine nucleotide binding, protein, alpha inhibiting polypeptide 3 0.01269 3499 ± 86 4248 ± 193 4496 ± 279 U03390_at Gnb2l1 guanine nucleotide binding protein, beta polypeptide 2-like 1 0.00065 9898 ± 620 12818 ± 198 11968 ± 401 M22400_at Gpc3 Glypican 3 0.00015 232 ± 30 427 ± 35 433 ± 26 rc_AA946251_at Gprk5 G protein-coupled receptor kinase 5 0.02059 138 ± 14 206 ± 17 222 ± 24 U29873_at Grin3a glutamate receptor, ionotropic, N-methyl-D-aspartate 3A 0.00483 250 ± 25 341 ± 17 354 ± 20 U73174_at Gsr glutathione reductase 0.00277 458 ± 30 542 ± 35 598 ± 10 X65948_at Gtf2b general transcription factor IIB 0.02847 1225 ± 78 1552 ± 41 1561 ± 114 L01267_at Gtf2f2 general transcription factor IIF, polypeptide 2 (30kD subunit) 0.00277 542 ± 34 722 ± 63 783 ± 34 rc_AA800912_g_at Gtf2ird1 general transcription factor II I repeat domain-containing 1 0.00001 1172 ± 55 1939 ± 49 1902 ± 114 rc_AI232374_at H1f0 Histone H1-0 0.00003 2087 ± 150 4076 ± 183 3447 ± 280 rc_AI232374_g_at H1f0 Histone H1-0 0.00022 1451 ± 142 3066 ± 227 2612 ± 247 rc_AA874802_s_at H1f0 Histone H1-0 0.00009 1525 ± 89 2930 ± 342 2791 ± 70 D16479_at Hadhb TP-beta 0.00010 2649 ± 161 3414 ± 120 3641 ± 119 U18650_at Hdh Huntington disease gene homolog 0.00000 350 ± 22 495 ± 10 524 ± 14 rc_AI007857_at Hgs HGF-regulated tyrosine kinase substrate 0.00226 3536 ± 152 4481 ± 147 4261 ± 177 M13170_at Hist1h1t histone 1, H1t 0.01488 85 ± 11 119 ± 9 122 ± 7 M27433_at Hist4 germinal histone H4 gene 0.00000 280 ± 16 689 ± 44 829 ± 50 rc_AA799893_g_at Hnrpa1 heterogeneous nuclear ribonucleoprotein A1 0.00000 1658 ± 117 2931 ± 79 2974 ± 122 rc_AI104524_s_at Hnrpab heterogeneous nuclear ribonucleoprotein A/B 0.00004 6878 ± 174 9540 ± 333 8546 ± 341 X16933cds_at Hnrpd RNA binding protein p45AUF1 0.00300 1704 ± 69 2220 ± 91 2115 ± 105 AB003726_at Homer1 homer, neuronal immediate early gene, 1 0.00023 1054 ± 50 1295 ± 40 1339 ± 37 AB007690_s_at Homer2 homer, neuronal immediate early gene, 2 0.02231 495 ± 43 667 ± 60 687 ± 42 L16764_s_at Hspa1a heat shock 70kD protein 1A 0.00000 2350 ± 94 3488 ± 108 3743 ± 162 Z27118cds_s_at Hspa1a heat shock 70kD protein 1A 0.00004 504 ± 50 887 ± 39 865 ± 54

Page 2 Supplementary Table 2: Infection-Sensitive Genes

Probe Set Symbol Title ANOVA Uninfected Ad-LacZ Ad-aCaN rc_AA800738_at Htatip HIV-1 Tat interactive protein, 60 kD 0.00098 1298 ± 46 1591 ± 91 1670 ± 44 M21410_s_at Htr2c 5-hydroxytryptamine (serotonin) receptor 2C 0.02960 291 ± 17 350 ± 16 355 ± 17 D49395_s_at Htr3a 5-hydroxytryptamine (serotonin) receptor 3a 0.00029 262 ± 28 459 ± 31 400 ± 24 L22558_at Htr7 5-hydroxytryptamine (serotonin) receptor 7 0.00030 385 ± 36 634 ± 49 660 ± 40 rc_AA801286_at Impa1 Inositol (myo)-1(or 4)-monophosphatase 1 0.00001 4756 ± 102 5835 ± 131 5537 ± 112 U20181_at Ireb2 iron-regulatory protein 2 0.00001 1758 ± 64 2430 ± 110 2365 ± 59 rc_AA799537_at Itpr3 inositol 1, 4, 5-triphosphate receptor 3 0.02405 1403 ± 87 1693 ± 93 1713 ± 65 M59980_s_at Kcnd2 potassium voltage gated channel, Shal-related family, member 2 0.00003 528 ± 26 916 ± 65 781 ± 37 AJ003065_at Kcnj14 potassium inwardly-rectifying channel J14 0.00238 209 ± 18 344 ± 25 311 ± 25 L21711_s_at Lgals5 Lectin, galactose binding, soluble 5 (Galectin-5) 0.00005 228 ± 19 529 ± 60 541 ± 38 U72741_g_at Lgals9 Lectin, galactose binding, soluble 9 (Galectin-9) 0.00005 218 ± 36 670 ± 76 665 ± 62 U72353_at Lmnb1 lamin B1 0.00310 94 ± 6 170 ± 17 180 ± 20 rc_AA955808_at LOC171121 protein phosphatase V 0.00852 1928 ± 106 2743 ± 170 2548 ± 187 U49058_at LOC245924 CTD-binding SR-like protein rA4 0.03506 859 ± 40 1027 ± 62 1030 ± 42 U25746_at LOC245957 RNA helicase 0.00001 878 ± 39 1208 ± 64 1254 ± 30 U78090_s_at LOC245960 potassium channel regulator 1 0.00013 1162 ± 64 1870 ± 71 1657 ± 112 rc_H31907_at LOC246185 embryo-related protein 0.00011 742 ± 39 1371 ± 77 1136 ± 94 AF068268_at LOC246268 2'5' oligoadenylate synthetase-2 0.00003 5 ± 1 81 ± 13 96 ± 13 rc_H31287_g_at LOC246273 kinase 0.00000 112 ± 15 498 ± 49 536 ± 35 AB000280_at LOC246280 peptide/histidine transporter 0.01432 799 ± 31 968 ± 52 959 ± 36 AF036335_at LOC252855 NonO/p54nrb homolog 0.00259 1825 ± 130 2532 ± 150 2426 ± 112 rc_AA859305_s_at LOC286890 tropomyosin isoform 6 0.00044 1472 ± 61 1893 ± 88 1949 ± 73 X67877_g_at LOC286917 cytosolic resiniferatoxin-binding protein 0.00004 2058 ± 45 2640 ± 91 2740 ± 101 AF071204_at LOC60427 stem cell factor KL-1 precursor 0.00032 113 ± 21 308 ± 24 283 ± 35 U79417_at LOC60627 component of rsec6/8 secretory complex p71 (71 kDa) 0.00002 1415 ± 79 1968 ± 71 1834 ± 43 U66478_at Madh1 MAD homolog 1 (Drosophila) 0.00000 298 ± 10 413 ± 20 459 ± 15 rc_AA800063_at Mark1 MAP/microtubule affinity-regulating kinase 1 0.00368 2244 ± 105 2683 ± 68 2644 ± 82 Z35654_at Mcf2l MCF.2 cell line derived transforming sequence-like 0.00003 863 ± 47 1225 ± 59 1123 ± 22 L10652_g_at Metap2 methionine aminopeptidase 2 0.00456 5109 ± 146 6033 ± 174 5779 ± 181 rc_AA874813_s_at Mfn2 mitofusin 2 0.00130 2368 ± 149 3129 ± 150 3084 ± 113 rc_AI111401_s_at Minpp1 multiple inositol polyphosphate histidine phosphatase 1 0.00003 972 ± 28 1455 ± 70 1472 ± 76 D63886_s_at Mmp16 matrix metalloproteinase 16 0.00003 1140 ± 66 1881 ± 85 1914 ± 120 rc_AA799508_at MPL3 microtubule-associated proteins 1A/1B light chain 3 0.01609 450 ± 44 579 ± 24 567 ± 22 J03524_s_at Mug1 alpha(1)-inhibitor 3, variant I 0.00809 25 ± 9 94 ± 16 91 ± 17 X52713_at Mx3 myxovirus (influenza virus) resistance 3 0.00054 81 ± 7 834 ± 132 784 ± 147 rc_AI237258_at Mybbp1a MYB binding protein 1a 0.00368 646 ± 48 826 ± 26 827 ± 35 Y00396mRNA_at Myc v-myc avian myelocytomatosis viral oncogene homolog 0.00003 470 ± 34 943 ± 67 1001 ± 80 AF020618_g_at Myd116 myeloid differentiation primary response gene 116 0.00001 927 ± 109 1809 ± 116 1704 ± 84 U50185_g_at Mypt1 myosin phosphatase, target subunit 1 0.00476 844 ± 31 1116 ± 77 1011 ± 35 AF069782_at Nap65 Nopp140 associated protein 0.00004 2279 ± 60 4022 ± 277 3641 ± 218 M55015cds_s_at Ncl Nucleolin 0.00004 4649 ± 346 6477 ± 268 6893 ± 239 Z12152_at Nef3 neurofilament 3, medium 0.00095 12256 ± 432 14659 ± 332 13892 ± 347

Page 3 Supplementary Table 2: Infection-Sensitive Genes

Probe Set Symbol Title ANOVA Uninfected Ad-LacZ Ad-aCaN L26267_at Nfkb1 nuclear factor kappa B p105 subunit 0.00295 1252 ± 31 1630 ± 166 1778 ± 55 M34238_at Nfya nuclear transcription factor-Y alpha 0.00002 232 ± 20 388 ± 19 394 ± 21 rc_AA817843_at Nfyb nuclear transcription factor - Y beta 0.00251 935 ± 73 1163 ± 44 1258 ± 54 U17607_at Nfyc nuclear transcription factor-Y gamma 0.00011 1099 ± 29 1517 ± 73 1468 ± 58 rc_AA874794_g_at Ngfrap1 nerve growth factor receptor (TNFRSF16) associated protein 1 0.01158 16937 ± 454 19022 ± 451 18403 ± 402 AF004431_at Nkx6a NK homeobox (Drosophila), family 6, A 0.00798 80 ± 17 152 ± 24 172 ± 17 X87157_at Nln neurolysin (metallopeptidase M3 family) 0.00498 1437 ± 51 1675 ± 64 1706 ± 50 rc_AA859942_at Nmt1 N-myristoyltransferase 1 0.00006 1752 ± 67 2284 ± 98 2181 ± 36 M94287_at Nopp140 nucleolar phosphoprotein p130 0.00000 3033 ± 44 4093 ± 158 4177 ± 82 U41845_at Npap60 nuclear pore associated protein 0.00818 524 ± 28 658 ± 33 634 ± 23 J04943_at Npm1 nucleophosmin 1 0.00000 1704 ± 57 2611 ± 83 2998 ± 173 rc_AA892598_at Ns nucleostemin 0.00001 1796 ± 105 3209 ± 126 2776 ± 186 rc_AI177052_at Nup153 nucleoporin 153kD 0.00009 674 ± 26 895 ± 56 952 ± 27 Z21780_at Nup155 nucleoporin 155kD 0.00023 1210 ± 57 1929 ± 108 1851 ± 123 Z18877_s_at Oas1 25 oligoadenylate synthetase 0.00001 622 ± 36 1148 ± 75 1169 ± 67 J04792_at Odc1 ornithine decarboxylase 1 0.00002 2614 ± 177 3809 ± 94 3670 ± 139 rc_AI229237_at Oprl opioid receptor-like 0.00017 387 ± 21 562 ± 30 491 ± 18 AB002086_g_at p47 p47 protein 0.00072 6940 ± 214 8106 ± 208 8050 ± 173 AF000900_g_at p58/p45 nucleoporin p58 0.00005 209 ± 21 339 ± 17 300 ± 9 AA801441_at Pafah1b1 platelet-activating factor acetylhydrolase beta subunit 0.00021 3376 ± 139 4538 ± 197 4407 ± 164 X64563cds_at Pai2a plasminogen activator inhibitor 2 type A 0.00388 58 ± 10 133 ± 15 103 ± 13 rc_AA997367_s_at Pak3 p21 (CDKN1A)-activated kinase 3 0.00070 1580 ± 31 1860 ± 74 1943 ± 58 AB005549_at Par3 three-PDZ containing protein similar to C. elegans PAR3 0.00067 1148 ± 57 1593 ± 86 1601 ± 80 rc_AA799729_g_at Pde4b Phosphodiesterase 4B, cAMP-specific 0.00009 1171 ± 142 1745 ± 73 1845 ± 55 rc_AA817887_at Pfn1 profilin 0.00002 8034 ± 270 10253 ± 398 10627 ± 264 D64046_g_at Pik3r2 phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 2 0.00197 546 ± 49 881 ± 51 816 ± 66 D84667_at Pik4cb phosphatidylinositol 4-kinase 0.02055 1283 ± 46 1552 ± 70 1539 ± 75 AF039832_g_at Pitx2 paired-like homeodomain transcription factor 2 0.00003 15 ± 3 149 ± 13 219 ± 34 M20636_s_at Plcb1 Phospholipase C-beta1 0.00028 866 ± 38 1228 ± 75 1084 ± 31 J03806_at Plcg1 Phospholipase C, gamma 1 0.02273 1366 ± 69 1597 ± 50 1618 ± 68 J04503_at Ppm1a Protein phosphatase type 1A (formely 2C), Mg-dependent, alpha isoform 0.00066 1819 ± 84 2664 ± 209 2803 ± 157 AF040954_at Ppp1r10 putative protein phosphatase 1 nuclear targeting subunit 0.00862 1479 ± 48 1784 ± 115 1783 ± 36 M23591mRNA#2_at Ppp2cb Protein phosphatase 2 (formerly 2A), catalytic subunit, beta isoform 0.00068 11636 ± 544 14190 ± 349 13872 ± 342 L29281_at Prkr Protein kinase, interferon-inducible double stranded RNA dependent 0.00032 569 ± 99 915 ± 88 1237 ± 98 AF031878_at Prph1 peripherin 1 0.00906 172 ± 12 247 ± 20 235 ± 15 X16554_at Prps1 phosphoribosyl pyrophosphate synthetase 1 0.00084 2924 ± 276 4053 ± 229 4243 ± 164 X16555_at Prps2 phosphoribosyl pyrophosphate synthetase 2 0.00059 349 ± 25 602 ± 50 572 ± 40 D21799_g_at Psmb2 proteasome (prosome, macropain) subunit, beta type 2 0.00001 7278 ± 281 8944 ± 165 8844 ± 149 D21800_at Psmb3 proteasome (prosome, macropain) subunit, beta type 3 0.00037 3608 ± 238 4613 ± 104 4466 ± 96 U13895_s_at Psmc2 Proteasome (prosome, macropain) 26S subunit, ATPase 0.00013 3998 ± 164 5069 ± 88 4758 ± 145 rc_AI176021_at Pten phosphatase and tensin homolog 0.00697 320 ± 27 446 ± 24 437 ± 28 M86564_at Ptma prothymosin alpha 0.00464 11656 ± 301 13837 ± 781 14146 ± 355

Page 4 Supplementary Table 2: Infection-Sensitive Genes

Probe Set Symbol Title ANOVA Uninfected Ad-LacZ Ad-aCaN L27843_s_at Ptp4a1 protein tyrosine phosphatase 4a1 0.00083 17571 ± 434 21196 ± 826 20992 ± 548 S49400_at Ptpn5 protein tyrosine phosphatase, non-receptor type 5 0.00215 2923 ± 108 3667 ± 177 3336 ± 82 M83676_at Rab12 RAB12, member RAS oncogene family 0.01157 4645 ± 139 5190 ± 132 5047 ± 80 M83681_at Rab3d RAB3D, member RAS oncogene family 0.00038 464 ± 26 664 ± 41 598 ± 18 U53475_at Rab8b GTPase Rab8b 0.03121 749 ± 69 1043 ± 110 1034 ± 61 rc_AI230602_at Rb2 Retinoblastoma-related gene 0.00402 1981 ± 128 2607 ± 84 2609 ± 150 U27767_at Rgs4 regulator of G-protein signaling 4 0.00037 4767 ± 328 6827 ± 537 7516 ± 357 U41164_at rKr1 Cys2/His2 zinc finger protein (rKr1) 0.00001 1109 ± 26 1395 ± 25 1337 ± 36 M20156_at Rpl18 ribosomal protein L18 0.00400 10063 ± 217 12324 ± 417 11708 ± 485 X52619_at Rpl28 ribosomal protein L28 0.03401 15163 ± 441 17738 ± 1017 17918 ± 701 AA944073_at Rpl41 ribosomal protein L41 0.01658 5386 ± 197 6336 ± 206 6194 ± 236 rc_AI639490_s_at Rps10 ribosomal protein S10 0.00012 273 ± 18 411 ± 22 461 ± 30 X06423_at Rps8 ribosomal protein S8 0.00893 12195 ± 259 13833 ± 195 13303 ± 407 U12187_at Rrad Ras-related associated with diabetes 0.00001 185 ± 15 297 ± 25 342 ± 11 L35271_at Runx1 Runt related transcription factor 1 0.01161 353 ± 24 435 ± 20 432 ± 14 rc_AA892268_at Ryk receptor-like tyrosine kinase 0.00000 727 ± 39 1208 ± 46 1118 ± 39 rc_AI071435_at Sacm2l SAC2 (supressor of actin mutations 2, homolog)-like (S. cerevisiae) 0.00408 1398 ± 74 1776 ± 97 1756 ± 61 U02983_at Scg3 secretogranin III 0.00900 9586 ± 203 10749 ± 250 10767 ± 307 U32575_g_at Sec6 RSec6 protein 0.00021 1622 ± 49 2065 ± 79 1922 ± 50 U08136_at Selel selectin, endothelial cell, ligand 0.02418 3299 ± 140 3742 ± 112 3760 ± 110 rc_AA893965_at Sfmbt Scm-related gene containing four mbt domains 0.01024 530 ± 38 715 ± 39 717 ± 48 rc_AI231164_s_at Sfrs10 splicing factor, arginine/serine-rich (transformer 2 Drosophila homolog) 10 0.00001 3362 ± 126 4478 ± 68 4324 ± 139 U70476_at Slc7a1 solute carrier family 7, member 1 0.00008 676 ± 52 997 ± 39 966 ± 39 AJ005113_at Smc1l1 SMC-like 1 (yeast) 0.00687 2217 ± 72 2515 ± 76 2516 ± 54 AF044910_g_at Smn survival motor neuron 0.00000 1164 ± 27 1633 ± 59 1716 ± 54 M29295_at Snrpb small nuclear ribonucleoprotein polypeptides B and B1 0.00023 3142 ± 296 4367 ± 149 4730 ± 217 U92072_at STXBP5 syntaxin binding protein 5 (tomosyn) 0.00061 940 ± 32 1082 ± 24 1155 ± 37 AJ006855_s_at Synj1 synaptojanin 1 0.01330 2925 ± 116 3671 ± 269 3666 ± 137 U14398_g_at Syt4 synaptotagmin 4 0.00247 8752 ± 378 10716 ± 523 10423 ± 171 U20108_at Sytv synaptogamin V 0.00079 212 ± 24 335 ± 20 288 ± 12 L12025_at Taa1 tumor-associated antigen 1 0.00052 80 ± 17 192 ± 24 223 ± 23 J05189_at Tacr3 tachikin receptor 3 0.00048 148 ± 7 234 ± 20 264 ± 20 S53913_s_at Tcf12 Transcription factor 12 0.01153 189 ± 24 298 ± 29 269 ± 17 rc_AA900850_at Tcp1 T-complex 1 0.00058 284 ± 27 385 ± 21 436 ± 22 AB010119_at Tctex1 t-complex testis expressed 1 0.00295 1775 ± 86 2081 ± 34 2079 ± 55 M61142_at Thop1 thimet oligopeptidase 1 0.00356 1020 ± 41 1299 ± 82 1292 ± 43 AB006451_at Timm23 translocase of inner mitochondrial membrane 23 homolog (yeast) 0.00002 4861 ± 112 6835 ± 167 6218 ± 286 E12829cds_at Tip120A TBP-interacting protein 120A 0.01171 1765 ± 102 2105 ± 66 2104 ± 73 X13058_at Tp53 tumor protein p53 0.00000 939 ± 61 1317 ± 60 1480 ± 48 L24777_at Tpm3 tropomyosin 3, gamma 0.00000 2069 ± 124 3102 ± 102 2997 ± 107 D17469_at Trhr Thyrotropin releasing hormone receptor 0.00022 159 ± 27 292 ± 19 319 ± 23 rc_AA875390_g_at Txnl thioredoxin-like (32kD) 0.02076 3242 ± 290 4043 ± 183 4164 ± 202

Page 5 Supplementary Table 2: Infection-Sensitive Genes

Probe Set Symbol Title ANOVA Uninfected Ad-LacZ Ad-aCaN L12138_at Tyms thymidylate synthase 0.00000 137 ± 6 259 ± 13 289 ± 17 AF099093_g_at Ubc7 ubiquitin-conjugating enzyme UBC7 0.00106 2128 ± 89 2757 ± 140 2502 ± 61 U13176_at Ube2d2 ubiquitin-conjugating enzyme E2D 2 0.00481 2739 ± 173 3528 ± 94 3230 ± 147 U54632_g_at Ube2i Ubiquitin conjugating enzyme E2I 0.01198 3102 ± 264 4164 ± 163 4218 ± 299 rc_AA859827_at Uck2 uridine-cytidine kinase 2 0.00083 580 ± 32 706 ± 41 781 ± 25 rc_AI228110_s_at Ugt8 UDP-glucuronosyltransferase 8 0.00003 239 ± 12 464 ± 29 581 ± 55 U24071_at Unc13h2 Munc13-2 protein 0.00012 155 ± 17 256 ± 20 253 ± 8 rc_AI008423_at Uncl unc-50 related protein (UNCL) 0.00011 2530 ± 203 3961 ± 231 4370 ± 278 rc_AA957961_at unr unr protein 0.00915 818 ± 59 1011 ± 72 1080 ± 38 AF026476_at Usf1 upstream transcription factor 1 0.00012 810 ± 34 1046 ± 38 1009 ± 25 M24104_at Vamp1 Vesicle-associated membrane protein 1 0.01157 769 ± 37 933 ± 40 963 ± 48 M98327_at Vars2 Valyl-tRNA synthetase 2 0.01927 667 ± 30 780 ± 41 788 ± 20 L20913_s_at Vegf vascular endothelial growth factor 0.00089 500 ± 28 738 ± 54 700 ± 32 L35767_at Vldlr Very low density lipoprotein receptor 0.00000 440 ± 21 633 ± 23 609 ± 19 rc_AA893188_at Xrcc5 X-ray repair cross complementation 0.00356 939 ± 104 1315 ± 68 1242 ± 37 Downregulated with Adenoviral Infection rc_AA946532_at Abcd3 ATP-binding cassette, sub-family D (ALD), member 3 0.00078 5136 ± 237 4367 ± 268 3765 ± 154 X05341_at Acaa2 acetyl-Coenzyme A acyltransferase 2 0.00152 2811 ± 154 2391 ± 66 2223 ± 71 rc_AI234950_at Acp2 acid phosphatase 2 0.02164 1195 ± 44 1030 ± 54 1064 ± 19 U35775_at Add3 adducin 3, gamma 0.00019 811 ± 53 639 ± 22 578 ± 19 M91466_at Adora2b adenosine A2B receptor 0.00000 234 ± 21 73 ± 12 104 ± 14 U17919_s_at Aif1 allograft inflammatory factor 1 0.00246 99 ± 10 62 ± 7 59 ± 6 rc_AA892821_at Akr7a2 aldo-keto reductase family 7, member A2 0.00057 484 ± 16 347 ± 41 344 ± 7 rc_AA800745_at Alad aminolevulinate,delta-,dehydratase 0.00009 904 ± 23 786 ± 17 775 ± 13 L34821_at Aldh5a1 aldehyde dehydrogenase family 5, subfamily A1 0.00480 307 ± 18 240 ± 7 265 ± 10 M63656_s_at Aldoc aldolase C, fructose-biphosphate 0.00000 13320 ± 550 3313 ± 169 4130 ± 386 U90829_at Appbp1 APP-binding protein 1 0.00070 1572 ± 49 1255 ± 59 1210 ± 64 L04760_at Arfd1 ADP-ribosylation factor domain protein 1, 64kD 0.00015 1363 ± 63 1150 ± 38 1045 ± 29 M74494_g_at Atp1a1 ATPase, Na+K+ transporting, alpha 1 0.00524 8243 ± 309 7146 ± 63 7005 ± 281 J04629_at Atp1b2 ATPase, Na+/K+ transporting, beta 2 polypeptide 0.00067 2900 ± 321 1632 ± 86 1918 ± 129 U15408_at Atp2b4 ATPase, Ca++ transporting, plasma membrane 4 0.00033 499 ± 32 326 ± 26 358 ± 20 rc_AI171844_at Atp5e ATP synthase, H+ transporting, mitochondrial F1 complex, epsilon 0.00775 11576 ± 468 10158 ± 297 9803 ± 338 rc_AA859645_at Atrn attractin 0.01617 1276 ± 35 1030 ± 56 1078 ± 64 D88035_at B3gat1 beta-1,3-glucuronyltransferase 1 (glucuronosyltransferase P) 0.00001 1773 ± 86 1251 ± 68 952 ± 102 U37142_at Bcan Brevican 0.00000 2500 ± 216 539 ± 84 747 ± 131 J02827_at Bckdha branched chain keto acid dehydrogenase subunit E1, alpha polypeptide 0.00000 500 ± 32 232 ± 18 269 ± 27 rc_AI168942_at Bckdhb branched chain keto acid dehydrogenase E1, beta polypeptide 0.00001 1154 ± 48 966 ± 20 884 ± 18 X67108_at Bdnf brain derived neurotrophic factor 0.00044 327 ± 18 239 ± 25 203 ± 14 U42755_at Bet1 blocked early in transport 1 homolog (S. cerevisiae) 0.00001 187 ± 13 95 ± 8 118 ± 7 AF009329_at Bhlhb3 basic helix-loop-helix domain containing, class B3 0.00001 627 ± 45 330 ± 34 390 ± 15 X71127_at C1qb complement component 1, q subcomponent, beta polypeptide 0.00002 267 ± 59 30 ± 6 28 ± 2 S83194_s_at Camkk1 calcium/calmodulin-dependent protein kinase kinase 1, alpha 0.00003 1681 ± 80 1360 ± 48 1182 ± 50

Page 6 Supplementary Table 2: Infection-Sensitive Genes

Probe Set Symbol Title ANOVA Uninfected Ad-LacZ Ad-aCaN rc_AI145367_at Cap2 adenylyl cyclase-associated protein 2 0.00175 933 ± 116 496 ± 40 598 ± 54 rc_AA998164_s_at Ccnb1 Cyclin B1 0.00002 164 ± 21 56 ± 9 52 ± 10 M57276_at Cd53 CD53 antigen 0.00039 144 ± 11 76 ± 11 76 ± 11 rc_AI227887_at Cdc42 cell division cycle 42 homolog (S. cerevisiae) 0.01944 2244 ± 149 1879 ± 99 1811 ± 69 D83348_at Cdh22 cadherin 22 0.00000 597 ± 37 300 ± 35 262 ± 23 AB009999_g_at Cds1 CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 1 0.00061 2369 ± 53 1863 ± 73 1998 ± 87 U66471_at Cgr19 cell growth regulatory with ring finger domain 0.00206 1031 ± 68 679 ± 83 691 ± 52 rc_AA894317_s_at Chn1 chimerin (chimaerin) 1 0.00717 2400 ± 122 2070 ± 66 1977 ± 70 U39875_at Chp calcium binding protein P22 0.00804 1780 ± 50 1527 ± 49 1585 ± 53 rc_AA892382_at Cml1 camello-like 1 0.02717 225 ± 9 168 ± 17 174 ± 15 L48209_s_at Cox8a cytochrome c oxidase, subunit VIIIa 0.01094 20950 ± 871 17228 ± 805 17667 ± 793 L07281_at Cpe Carboxypeptidase E 0.00926 24258 ± 344 21671 ± 398 21040 ± 925 U35099_at Cplx2 complexin 2 0.00013 1590 ± 93 1183 ± 111 954 ± 56 M54987_at Crh corticotropin releasing hormone 0.00129 177 ± 8 129 ± 6 152 ± 8 AF003904mRNA_g_at Crhbp corticotropin releasing hormone binding protein 0.00000 336 ± 26 66 ± 12 91 ± 18 rc_AA818843_s_at Cript postsynaptic protein Cript 0.02712 2415 ± 164 1979 ± 136 1958 ± 69 U26033_at Crot carnitine O-octanoyltransferase 0.00000 695 ± 45 326 ± 20 412 ± 27 M64755_at Csad cysteine-sulfinate decarboxylase 0.00000 536 ± 30 295 ± 18 367 ± 17 AF072892_s_at Cspg2 chondroitin sulfate proteoglycan 2 (versican) 0.00000 745 ± 36 482 ± 24 563 ± 17 M97161_at Cspg3 chondroitin sulfate proteoglycan 3 0.00061 1004 ± 57 577 ± 81 708 ± 53 U33553_at Cspg5 chondroitin sulfate proteoglycan 5 0.00863 5283 ± 262 4482 ± 186 4356 ± 160 D90404_g_at Ctsc cathepsin C 0.00004 331 ± 47 108 ± 11 184 ± 9 X54467_at Ctsd cathepsin D 0.00390 4534 ± 123 3654 ± 166 3855 ± 178 L03201_at Ctss cathepsin S 0.00000 745 ± 57 243 ± 22 220 ± 17 AF030358_g_at Cx3cl1 chemokine (C-X3-C motif) ligand 1 0.00079 9246 ± 607 7569 ± 366 6487 ± 327 AF007107_s_at Cyb5 cytochrome b5 0.00024 1888 ± 88 1183 ± 107 1293 ± 104 M38566mRNA_s_at Cyp27 cytochrome P450, family 27, subfamily a, polypeptide 1 0.00015 271 ± 27 183 ± 13 140 ± 12 rc_AA997886_s_at Cyp2d18 cytochrome P450 2d18 0.00958 2490 ± 86 1924 ± 147 1935 ± 137 U39943_s_at Cyp2J3 cytochrome P450 monooxygenase 0.00000 149 ± 15 31 ± 10 37 ± 5 M94548_at Cyp4f14 cytochrome P450, subfamily IVF, polypeptide 14 0.00004 228 ± 25 113 ± 9 93 ± 14 U36992_at Cyp7b1 cytochrome P450, subfamily 7B, polypeptide 1 0.00000 2030 ± 77 503 ± 96 609 ± 53 rc_AA800784_at Cyr61 cysteine rich protein 61 0.00006 533 ± 56 248 ± 18 344 ± 22 U95178_s_at Dab2 disabled homolog 2, mitogen-responsive phosphoprotein 0.00000 445 ± 25 68 ± 7 138 ± 26 AF044574_g_at Decr2 2-4-dienoyl-Coenzyme A reductase 2, peroxisomal 0.00197 312 ± 22 217 ± 17 221 ± 15 rc_AA859529_at Dgat1 diacylglycerol O-acyltransferase 1 0.00021 1722 ± 54 1382 ± 65 1387 ± 40 S49760_g_at Dgka diacylglycerol kinase, alpha (80 kDa) 0.00000 1139 ± 27 834 ± 38 775 ± 30 rc_AA963839_s_at Dia1 diaphorase 1 0.00000 2559 ± 99 1204 ± 77 1359 ± 80 AB013359_at Dpm2 dolichol-phosphate mannosyltransferase 2 0.00017 1415 ± 105 1023 ± 40 960 ± 42 X94185cds_s_at Dusp6 dual specificity phosphatase 6 0.00569 2235 ± 184 1705 ± 59 1705 ± 79 X96426_at Eef2k Eukaryotic elongation factor 2 kinase 0.00170 618 ± 41 437 ± 49 397 ± 29 rc_AI230130_at Entpd2 ectonucleoside triphosphate diphosphohydrolase 2 0.00000 788 ± 35 184 ± 29 277 ± 36 U07619_at F3 coagulation factor 3 0.00000 312 ± 19 158 ± 16 195 ± 9

Page 7 Supplementary Table 2: Infection-Sensitive Genes

Probe Set Symbol Title ANOVA Uninfected Ad-LacZ Ad-aCaN U72497_at Faah fatty acid amide hydrolase 0.00006 2614 ± 100 1875 ± 138 1914 ± 65 M32062_g_at Fcgr3 Fc receptor, IgG, low affinity III 0.00000 265 ± 25 126 ± 18 93 ± 9 D12498_s_at Fgfr1 Fibroblast growth factor receptor 1 0.00001 7659 ± 304 5245 ± 244 5208 ± 296 D86642_at Fkbp1b FK506 binding protein 1b 0.00136 1008 ± 57 764 ± 49 738 ± 40 M59861_at Fthfd 10-formyltetrahydrofolate dehydrogenase 0.00000 356 ± 17 127 ± 31 156 ± 17 AF080468_at G6pt1 glucose-6-phosphatase, transport protein 1 0.00079 1029 ± 38 883 ± 25 769 ± 48 rc_AI228669_at Gabt1 GABA transporter protein 0.00022 6581 ± 365 4940 ± 230 4615 ± 257 X57573_at Gad1 Glutamate decarboxylase 1 (brain) 0.00037 10170 ± 603 8218 ± 308 7398 ± 302 U07971_at Gatm glycine amidinotransferase (L-arginine:glycine amidinotransferase) 0.00000 1281 ± 99 600 ± 41 720 ± 36 AF090867_g_at Gmpr guanosine monophosphate reductase 0.00000 969 ± 32 606 ± 26 549 ± 39 AF109405_s_at Gpr51 G protein-coupled receptor 51 0.00087 1145 ± 57 933 ± 48 812 ± 53 rc_AA799891_g_at GRASP65 golgi peripheral membrane protein p65 0.00002 1119 ± 81 672 ± 44 635 ± 50 M36419_s_at Gria2 glutamate receptor, ionotropic, 2 0.00168 4775 ± 174 4127 ± 260 3707 ± 113 U08257_at Grik4 Glutamate receptor, ionotropic, kainate 4 0.00000 1275 ± 56 936 ± 51 790 ± 33 U11418_s_at Grin1 glutamate receptor, ionotropic, N-methyl D-aspartate 1 0.00172 689 ± 34 530 ± 31 512 ± 31 M90518_at Grm4 glutamate receptor, metabotropic 4 0.00657 1779 ± 140 1238 ± 100 1342 ± 88 rc_AI105137_s_at GST13-13 glutathione S-transferase, mitochondrial 0.00000 706 ± 40 287 ± 33 396 ± 28 rc_AI012802_at Hagh Hydroxyacyl glutathione hydrolase 0.00000 1873 ± 80 1200 ± 62 1025 ± 36 X06827_g_at Hmbs Hydroxymethylbilane synthase 0.00000 586 ± 23 284 ± 18 295 ± 20 M33648_g_at Hmgcs2 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2 0.00000 2559 ± 207 516 ± 57 587 ± 39 U05013_at Hmox2 heme oxygenase 2 0.00001 1054 ± 42 828 ± 44 734 ± 22 M63983_s_at HpRt hypoxanthine guanine phosphoribosyl transferase 0.00103 3399 ± 231 2718 ± 182 2216 ± 164 D49363_s_at Hrsp12 heat-responsive protein 12 0.00000 1746 ± 126 638 ± 26 715 ± 36 rc_AA945583_at Hsd17b10 hydroxysteroid (17-beta) dehydrogenase 10 0.01210 796 ± 37 643 ± 39 663 ± 29 rc_AI013834_s_at Hsd17b4 peroxisomal multifunctional enzyme type II 0.00000 2498 ± 78 1428 ± 79 1536 ± 116 M15481_g_at Igf1 insulin-like growth factor 1 0.00369 629 ± 46 388 ± 27 436 ± 51 U77777_s_at Il18 interleukin 18 0.00000 133 ± 13 53 ± 10 45 ± 6 M95578_g_at Il1r1 Interleukin 1 receptor, type I 0.01771 133 ± 15 85 ± 13 80 ± 11 X56917_at Itpka inositol 1,4,5-triphosphate 3-kinase 0.00000 2586 ± 41 1959 ± 127 1734 ± 81 J05031_g_at Ivd Isovaleryl Coenzyme A dehydrogenase 0.00000 2419 ± 76 1670 ± 53 1519 ± 49 Z50144_g_at Kat2 kynurenine aminotransferase 2 0.00000 122 ± 14 13 ± 5 17 ± 5 X16476cds_at Kcnb1 Potassium voltage gated channel, Shab-related subfamily, member 1 0.00004 669 ± 31 530 ± 35 450 ± 15 X62839mRNA_s_at Kcnc2 potassium voltage gated channel, Shaw-related subfamily, member 2 0.00153 988 ± 99 625 ± 81 558 ± 51 AF000973_s_at Kcnn1 Ca2+ activated K+ channel, intermediate/small conductance, N1 0.00001 706 ± 30 500 ± 23 501 ± 23 U69882_at Kcnn2 Ca2+ activated K+ channel, intermediate/small conductance, N2 0.00108 401 ± 35 294 ± 23 248 ± 18 AF091247_s_at Kcnq3 potassium voltage-gated channel, subfamily Q, member 3 0.00002 1256 ± 82 889 ± 44 799 ± 37 D12524_g_at Kit c-kit receptor tyrosine kinase 0.00580 775 ± 35 627 ± 26 619 ± 35 U28356_at LC-PTP protein-tyrosine phosphatase, non-receptor type 7 0.00002 369 ± 37 166 ± 11 164 ± 23 U56732_at LOC246264 KRAB/zinc finger suppressor protein 1 (KS1) 0.00007 252 ± 12 195 ± 12 169 ± 8 rc_AA866257_at LOC246768 cytosolic leucine-rich protein 0.00267 3284 ± 219 2587 ± 114 2510 ± 103 U95162_at LOC56769 nuclear protein E3-3 0.00005 416 ± 13 326 ± 12 304 ± 16 AB011369_s_at LOC60383 protein kinase C-binding protein Beta15 0.00113 3054 ± 170 2376 ± 64 2235 ± 148

Page 8 Supplementary Table 2: Infection-Sensitive Genes

Probe Set Symbol Title ANOVA Uninfected Ad-LacZ Ad-aCaN rc_AA859975_at LOC64201 2-oxoglutarate carrier 0.00679 2410 ± 83 2091 ± 98 2015 ± 67 rc_AA891880_g_at Loc65042 tricarboxylate carrier-like protein 0.00019 2982 ± 93 2324 ± 79 2308 ± 117 U81186_g_at LOC84013 smooth muscle-specific 17 beta-hydroxysteroid dehydrogenase type 3 0.00000 5198 ± 148 3412 ± 81 3811 ± 161 L34049_g_at Lrp2 low density lipoprotein receptor-related protein 2 0.00000 729 ± 23 383 ± 41 404 ± 14 rc_AA892810_at Lrpap1 low density lipoprotein receptor-related protein associated protein 1 0.00008 2277 ± 81 1836 ± 72 1723 ± 67 U56242_at Maf v-maf musculoaponeurotic fibrosarcoma (avian) oncogene homolog (c-maf) 0.00000 501 ± 29 298 ± 17 356 ± 10 rc_AA957896_s_at Map2k2 mitogen activated protein kinase kinase 2 0.00118 3185 ± 155 2536 ± 66 2643 ± 92 AF095741_g_at Mg87 Mg87 protein 0.00076 1956 ± 72 1546 ± 78 1617 ± 50 S73424_s_at Mif macrophage migration inhibitory factor 0.00033 25580 ± 1199 20970 ± 886 19911 ± 493 M93401_at Mmsdh methylmalonate semialdehyde dehydrogenase gene 0.00003 1246 ± 55 834 ± 47 806 ± 61 U62635_s_at Mrpl23 mitochondrial ribosomal protein L23 0.00627 2433 ± 98 2094 ± 101 1963 ± 86 S74265_s_at Mtap2 microtubule-associated protein 2 0.00103 207 ± 22 110 ± 15 146 ± 8 Y09333_g_at Mte1 mitochondrial acyl-CoA thioesterase 1 0.00000 1267 ± 64 608 ± 28 740 ± 65 rc_AI175935_at Myo1e myosin IE 0.00069 753 ± 39 499 ± 38 598 ± 35 rc_H31914_at Ncl Nucleolin 0.00001 161 ± 12 49 ± 15 65 ± 12 AB012235_at Nfix nuclear factor I/X 0.01544 2958 ± 227 2133 ± 219 1907 ± 257 rc_AI044716_at Nptx1 neuronal pentraxin 1 0.00155 370 ± 25 280 ± 18 229 ± 26 M15880_at Npy Neuropeptide Y 0.00019 6245 ± 335 5224 ± 112 4695 ± 159 U14533_at Nr1h2 nuclear receptor subfamily 1, group H, member 2 0.00002 2668 ± 96 1995 ± 86 2074 ± 64 rc_AI176710_at Nr4a3 nuclear receptor subfamily 4, group A, member 3 0.00144 6817 ± 290 4949 ± 362 5256 ± 301 AF016296_at Nrp neuropilin 0.00000 4007 ± 192 2432 ± 124 2169 ± 65 X97121_at Ntsr2 neurotensin receptor 2 0.00000 399 ± 26 139 ± 16 193 ± 21 U70825_at Oplah 5-oxoprolinase (ATP-hydrolysing) 0.00004 337 ± 37 128 ± 17 181 ± 19 rc_AI009098_at Orp150 oxygen regulated protein (150kD) 0.00061 3111 ± 172 2417 ± 105 2335 ± 103 rc_AI230712_at Pace4 Subtilisin - like endoprotease 0.00090 702 ± 40 429 ± 48 540 ± 37 AF076183_g_at Pacs1 cytosolic sorting protein PACS-1 0.00740 4826 ± 276 3932 ± 140 3980 ± 156 X83231_at PAIHC3 pre-alpha-inhibitor, heavy chain 3 0.00013 247 ± 14 152 ± 11 148 ± 16 U32314_g_at Pc Pyruvate carboxylase 0.00000 692 ± 41 340 ± 29 337 ± 10 M22631_at Pcca Propionyl Coenzyme A carboxylase, alpha polypeptide 0.00406 866 ± 24 734 ± 22 740 ± 30 M83746_at Pcsk2 proprotein convertase subtilisin/kexin type 2 0.01280 4531 ± 179 4145 ± 74 4010 ± 80 U21101_at Pde2a cyclic GMP stimulated phosphodiesterase 0.00000 2565 ± 138 1668 ± 53 1437 ± 66 AB016532_at Per2 period homolog 2 0.00268 649 ± 58 396 ± 30 431 ± 47 U25651_at Pfkm phosphofructokinase, muscle 0.00019 5990 ± 271 4967 ± 209 4479 ± 159 L11694_at Pgm1 Phosphoglucomutase 1 0.00000 1540 ± 101 1049 ± 22 975 ± 39 M73808mRNA_at Phkg2 phosphorylase kinase, gamma 2 (testis) 0.00008 905 ± 45 632 ± 26 613 ± 43 rc_AA800228_at Pippin PIPPin protein 0.00012 2898 ± 207 2108 ± 98 1982 ± 64 M64092_at Pkib protein kinase (cAMP dependent, catalytic) inhibitor beta 0.00003 142 ± 17 53 ± 8 58 ± 8 U51898_at Pla2g6 phospholipase A2, group VI 0.00416 757 ± 39 594 ± 41 603 ± 21 U16655_at Plcd4 phospholipase C, delta 4 0.00000 455 ± 23 248 ± 13 281 ± 16 M25888_at Plp proteolipid protein 0.00064 1450 ± 110 867 ± 109 1066 ± 42 D13907_at Pmpcb mitochondrial processing peptidase beta 0.00028 1693 ± 46 1446 ± 48 1409 ± 36 AJ001641_at Pou3f3 POU domain, class 3, transcription factor 3 0.00533 1968 ± 105 1387 ± 92 1488 ± 129

Page 9 Supplementary Table 2: Infection-Sensitive Genes

Probe Set Symbol Title ANOVA Uninfected Ad-LacZ Ad-aCaN AF014009_at Prdx6 peroxiredoxin 6 0.00100 1637 ± 69 1181 ± 63 1366 ± 72 U42413_at Prkag1 protein kinase, AMP-activated, gamma 1 non-catalytic subunit 0.01646 1821 ± 90 1527 ± 42 1589 ± 60 M13707_at Prkcc protein kinase C, gamma 0.00000 5342 ± 277 3372 ± 152 3104 ± 60 rc_AA891871_s_at Prpsap1 phosphoribosylpyrophosphate synthetase-associated protein (39 kDa) 0.00025 1611 ± 84 1340 ± 34 1188 ± 53 X99267_g_at Psen2 presenilin-2 0.00392 1366 ± 63 1090 ± 64 1137 ± 34 AB022014_at Psmd10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 0.00273 454 ± 28 346 ± 12 368 ± 17 AF063890_s_at Ptk2b protein tyrosine kinase 2 beta 0.00519 1653 ± 106 1264 ± 79 1171 ± 98 D85183_s_at Ptpns1 protein tyrosine phosphatase, non-receptor type substrate 1 0.00000 3109 ± 115 1915 ± 95 2152 ± 89 L01702_at Ptpra Protein tyrosine phosphatase, receptor type, A 0.00034 1336 ± 50 1074 ± 54 1003 ± 46 U04998_at Ptprz1 protein tyrosine phosphatase, receptor-type, Z polypeptide 1 0.00000 694 ± 50 242 ± 22 290 ± 14 X70223_at Pxmp2 peroxisomal membrane protein 2 0.00000 469 ± 40 198 ± 18 280 ± 15 E03344cds_s_at Pxmp3 peroxisomal membrane protein 3 0.00660 382 ± 50 206 ± 29 249 ± 24 M27726_at Pygb Brain glycogen phosphorylase 0.00166 1462 ± 47 1053 ± 70 1162 ± 75 X78606_at Rab28 RAB28, member RAS oncogene family 0.00005 2699 ± 99 1764 ± 162 1978 ± 85 rc_AI176621_at Ratireb iron-responsive element-binding protein 0.00002 2784 ± 48 2381 ± 52 2411 ± 49 rc_AI639318_at Ret ret proto-oncogene 0.00000 478 ± 22 277 ± 18 260 ± 23 AF036548_g_at Rgc32 Rgc32 protein 0.00000 3252 ± 200 1209 ± 66 1270 ± 86 AF035151_s_at Rgs12 regulator of G-protein signaling 12 0.00011 1421 ± 57 994 ± 55 1151 ± 50 AF068136_at Rgs19 regulator of G-protein signalling 19 0.02328 1207 ± 37 1061 ± 28 1056 ± 45 AB006013_at Rgs8 regulator of G-protein signaling 8 0.00000 481 ± 30 259 ± 22 249 ± 20 U92564_at Roaz Olf-1/EBF associated Zn finger protein Roaz 0.00000 906 ± 57 442 ± 48 509 ± 22 U16025_at RT1-M3 RT1 class Ib gene, locus M3 0.00000 1715 ± 35 1086 ± 17 1189 ± 43 rc_AI073164_at Scamp1 secretory carrier membrane protein 1 0.00030 5359 ± 208 4475 ± 197 4232 ± 106 M22254_at Scn2a1 sodium channel, voltage-gated, type 2, alpha 1 polypeptide 0.00275 3950 ± 103 3201 ± 262 3145 ± 73 rc_AA925248_at Scn6a sodium channel, voltage-gated, type 6, alpha polypeptide 0.00000 1068 ± 162 182 ± 29 196 ± 16 rc_AI230247_s_at Sepp1 selenoprotein P, plasma, 1 0.00000 687 ± 99 116 ± 14 171 ± 12 U55816_at Slc12a5 solute carrier family 12, (potassium-chloride transporter) member 5 0.00152 4216 ± 147 3139 ± 280 3462 ± 85 rc_AI232096_at Slc15a2 solute carrier family 15, member 2 0.00000 478 ± 22 139 ± 14 147 ± 11 rc_AA800120_at Slc25a20 solute carrier family 25 (carnitine/acylcarnitine translocase), member 20 0.00008 1090 ± 25 808 ± 52 871 ± 28 U89529_at Slc27a1 fatty acid transport protein 0.00000 2401 ± 196 1277 ± 57 1448 ± 49 AF004017_at Slc4a4 solute carrier family 4, member 4 0.00000 1089 ± 77 297 ± 41 349 ± 48 M85299_at Slc9a1 solute carrier family 9, member 1 0.00004 1800 ± 121 1437 ± 48 1218 ± 25 D17764_at Sncb synuclein, beta 0.02291 2373 ± 125 1970 ± 75 2030 ± 90 AF023621_at Sort1 sortilin 1 0.00265 592 ± 35 468 ± 30 395 ± 37 AB001347_s_at Spnb3 beta-spectrin 3 0.00196 2647 ± 69 2267 ± 83 2144 ± 100 J05035_at Srd5a1 steroid 5 alpha-reductase 1 0.01589 806 ± 63 592 ± 47 619 ± 41 rc_AA892557_g_at Srm spermidine synthase 0.00001 429 ± 29 233 ± 21 260 ± 15 D89731_at Stk12 serine/threonine kinase 12 0.00005 291 ± 27 105 ± 18 155 ± 22 L19998_at Sult1a1 sulfotransferase family 1A, phenol-preferring, member 1 0.00000 201 ± 17 83 ± 13 95 ± 6 AF060173_at Svop SV2 related protein 0.00011 2950 ± 220 1873 ± 105 1871 ± 136 D12927_at Tcea2 transcription elongation factor A2 0.00174 2156 ± 115 1589 ± 112 1660 ± 81 D10926_s_at Tfpi tissue factor pathway inhibitor 0.00209 667 ± 55 487 ± 26 486 ± 21

Page 10 Supplementary Table 2: Infection-Sensitive Genes

Probe Set Symbol Title ANOVA Uninfected Ad-LacZ Ad-aCaN X12744_at Thra thyroid hormone receptor alpha 0.00337 1879 ± 193 1272 ± 107 1241 ± 77 rc_AI172476_at Tieg TGFB inducible early growth response 0.00137 1417 ± 44 1032 ± 29 1101 ± 86 S72594_s_at Timp2 tissue inhibitor of metalloproteinase 2 0.00493 9034 ± 397 7832 ± 256 7587 ± 218 U75916_at Tjp2 tight junction protein 2 0.00000 664 ± 34 300 ± 25 363 ± 17 rc_AA899854_at Top2a topoisomerase (DNA) 2 alpha 0.00000 723 ± 25 246 ± 13 262 ± 10 X56228_at Tst thiosulfate sulfurtransferase 0.00000 2745 ± 130 1323 ± 43 1355 ± 77 D37880_at Tyro3 TYRO3 protein tyrosine kinase 3 0.01616 1074 ± 81 843 ± 26 856 ± 49 U91561_g_at U91561 pyridoxine 5-phosphate oxidase 0.00000 930 ± 29 535 ± 25 620 ± 27 D83796_s_at Ugt1a6 UDP glycosyltransferase 1 family, polypeptide A6 0.00774 1186 ± 45 864 ± 84 927 ± 63 S63830_s_at Vamp3 vesicle-associated membrane protein 3 0.00000 3404 ± 129 1433 ± 49 1671 ± 44 U14746_at Vhl von Hippel-Lindau syndrome homolog 0.00078 3034 ± 62 2483 ± 104 2518 ± 99

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