Supplementary Table 2: Infection-Sensitive Genes Supplementary Table 2: Upregulated with Adenoviral Infection (pages 1 - 7)- genes that were significant by ANOVA as well as significantly increased in control compared to both 'infected control' (Ad-LacZ) and 'calcineurin infected' (Ad-aCaN). Downregulated with Adenoviral Infection (pages 7 - 13) as above except for direction of change. Columns: Probe Set- Affymetrix probe set identifier for RG-U34A microarray, Symbol and Title- annotated information for above probe set (annotation downloaded June, 2004), ANOVA- p-value for 1-way Analysis of Variance, Uninfected, Ad-LacZ and Ad- aCaN- mean ± SEM expression for uninfected control, adenovirus mediated LacZ treated control, and adenovirus mediated calcineurin treated cultures respectively. Upregulated with Adenoviral Infection Probe Set Symbol Title ANOVA Uninfected Ad-LacZ Ad-aCaN Z48444cds_at Adam10 a disintegrin and metalloprotease domain 10 0.00001 837 ± 31 1107 ± 24 1028 ± 29 L26986_at Adcy8 adenylyl cyclase 8 0.00028 146 ± 12 252 ± 21 272 ± 21 U94340_at Adprt ADP-ribosyltransferase 1 0.00695 2096 ± 100 2783 ± 177 2586 ± 118 U01914_at Akap8 A kinase anchor protein 8 0.00080 993 ± 44 1194 ± 65 1316 ± 44 AB008538_at Alcam activated leukocyte cell adhesion molecule 0.01012 2775 ± 136 3580 ± 216 3429 ± 155 M34176_s_at Ap2b1 adaptor-related protein complex 2, beta 1 subunit 0.01389 2408 ± 199 2947 ± 143 3071 ± 116 D44495_s_at Apex1 apurinic/apyrimidinic endonuclease 1 0.00089 4959 ± 185 5816 ± 202 6057 ± 158 U16245_at Aqp5 aquaporin 5 0.02710 168 ± 6 214 ± 9 216 ± 17 L12383_at Arf4 ADP-ribosylation factor 4 0.00001 8634 ± 125 10596 ± 121 10465 ± 291 rc_AA944324_at Arf6 ADP-ribosylation factor 6 0.00000 3016 ± 122 4546 ± 203 4164 ± 123 U90887_at Arg2 arginase 2 0.00000 415 ± 25 891 ± 42 907 ± 34 AF017756_at Axin GSK-3beta interacting protein rAxin 0.00003 965 ± 51 1352 ± 53 1372 ± 52 M75168_at Bat1a HLA-B-associated transcript 1A 0.00331 2403 ± 131 3116 ± 82 3016 ± 157 rc_AA892014_s_at Bat1a HLA-B-associated transcript 1A 0.00000 5108 ± 198 8177 ± 483 7792 ± 149 rc_AI010293_at Bat3 HLA-B-associated transcript 3 0.00000 2198 ± 63 3271 ± 109 2981 ± 82 L26268_at Btg1 B-cell translocation gene 1 0.00059 3958 ± 229 4921 ± 121 5280 ± 224 L02315_at Cacnb4 calcium channel beta 4 subunit 0.00095 231 ± 17 310 ± 8 304 ± 14 L27487_at Calcrl calcitonin receptor-like 0.01445 147 ± 13 202 ± 18 215 ± 15 U53859_at Capns1 calpain, small subunit 1 0.02169 5700 ± 343 6902 ± 213 6675 ± 280 U77933_at Casp2 caspase 2 0.00000 1085 ± 37 1749 ± 98 1969 ± 78 U49930_g_at Casp3 caspase 3 0.00004 1276 ± 59 1589 ± 60 1730 ± 49 AF087437UTR#1_s_at Cbfb core binding factor beta 0.00002 4776 ± 306 6158 ± 235 6601 ± 97 L11007_at Cdk4 cyclin-dependent kinase 4 0.00004 4838 ± 135 6305 ± 330 6599 ± 173 X83579_at Cdk7 cyclin-dependent kinase 7 0.00015 599 ± 35 838 ± 46 903 ± 43 U11031_at Cntn3 contactin 3 0.00012 128 ± 22 230 ± 29 278 ± 9 X95466_at CPG2 CPG2 protein 0.00266 242 ± 18 381 ± 34 349 ± 20 X14788_s_at Creb1 cAMP response element binding protein 1 0.01655 514 ± 31 694 ± 44 680 ± 47 L15618_at Csnk2a1 casein kinase II, alpha 1 polypeptide 0.00156 772 ± 75 1096 ± 71 1124 ± 50 rc_AI230260_s_at Csnk2b casein kinase II beta subunit 0.00018 5811 ± 279 8088 ± 232 7203 ± 334 U44948_at Csrp2 cysteine rich protein 2 0.00014 1332 ± 56 1703 ± 68 1785 ± 63 U17035_s_at Cxcl10 chemokine (C-X-C motif) ligand 10 0.00007 149 ± 8 722 ± 106 637 ± 72 D83948mRNA_at D83948 RNA binding motif protein 10 0.00844 1111 ± 56 1359 ± 25 1315 ± 59 AF039583_s_at Daf decay-accelarating factor 0.00021 148 ± 28 302 ± 28 347 ± 29 X62160_at Dctn1 dynactin 1 0.00504 7885 ± 432 9401 ± 282 8979 ± 130 Page 1 Supplementary Table 2: Infection-Sensitive Genes Probe Set Symbol Title ANOVA Uninfected Ad-LacZ Ad-aCaN U30186_at Ddit3 DNA-damage inducible transcript 3 0.00006 1050 ± 71 1447 ± 52 1534 ± 62 AF063447_at Ddxl nuclear RNA helicase, DECD variant of DEAD box family 0.00000 1183 ± 89 2338 ± 201 2304 ± 44 D31734_g_at Dlx5 Distal-less homeobox 0.00037 439 ± 11 600 ± 53 641 ± 17 U15138_at Dncli2 LIC-2 dynein light intermediate chain 53/55 0.00273 12227 ± 687 13992 ± 400 15038 ± 413 AB012214_s_at Dnmt1 DNA (cytosine-5-)-methyltransferase 1 0.00005 1431 ± 42 2128 ± 99 1975 ± 95 U31777_g_at Drpla dentatorubral pallidoluysian atrophy 0.00447 2057 ± 371 3297 ± 119 2890 ± 143 L05489_at Dtr diphtheria toxin receptor 0.00000 477 ± 37 717 ± 24 796 ± 22 rc_AI104012_at Dyrk1a dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.00002 475 ± 31 634 ± 22 713 ± 28 Y16188_at Ecel1 endothelin converting enzyme-like 1 0.00305 311 ± 26 459 ± 32 412 ± 21 K01677_at Eif5 eukaryotic initiation factor 5 (eIF-5) 0.00433 535 ± 32 728 ± 58 725 ± 30 M19651_at Fosl1 Fos-like antigen 1 0.01169 38 ± 4 195 ± 69 236 ± 36 U09583_at Frk src related tyrosine kinase 0.00771 24 ± 4 48 ± 3 44 ± 6 rc_AA858520_g_at Fst follistatin 0.00004 190 ± 12 300 ± 10 356 ± 27 AF058791_at G10 maternal G10 transcript 0.00008 2406 ± 91 3085 ± 94 3130 ± 108 X15467cds_at Gabrb2 Gamma-aminobutyric acid receptor beta 2 0.01864 257 ± 24 375 ± 23 374 ± 35 M80367_at Gbp2 guanylate binding protein 2, interferon-inducible 0.00009 90 ± 17 463 ± 79 428 ± 42 rc_AA891829_g_at Gch GTP cyclohydrolase 1 0.00033 1185 ± 109 1714 ± 69 1572 ± 47 AF087431_g_at Gcs1 glucosidase 1 0.00060 2139 ± 112 2859 ± 152 2604 ± 53 rc_AI228247_at Gnai3 Guanine nucleotide binding, protein, alpha inhibiting polypeptide 3 0.01269 3499 ± 86 4248 ± 193 4496 ± 279 U03390_at Gnb2l1 guanine nucleotide binding protein, beta polypeptide 2-like 1 0.00065 9898 ± 620 12818 ± 198 11968 ± 401 M22400_at Gpc3 Glypican 3 0.00015 232 ± 30 427 ± 35 433 ± 26 rc_AA946251_at Gprk5 G protein-coupled receptor kinase 5 0.02059 138 ± 14 206 ± 17 222 ± 24 U29873_at Grin3a glutamate receptor, ionotropic, N-methyl-D-aspartate 3A 0.00483 250 ± 25 341 ± 17 354 ± 20 U73174_at Gsr glutathione reductase 0.00277 458 ± 30 542 ± 35 598 ± 10 X65948_at Gtf2b general transcription factor IIB 0.02847 1225 ± 78 1552 ± 41 1561 ± 114 L01267_at Gtf2f2 general transcription factor IIF, polypeptide 2 (30kD subunit) 0.00277 542 ± 34 722 ± 63 783 ± 34 rc_AA800912_g_at Gtf2ird1 general transcription factor II I repeat domain-containing 1 0.00001 1172 ± 55 1939 ± 49 1902 ± 114 rc_AI232374_at H1f0 Histone H1-0 0.00003 2087 ± 150 4076 ± 183 3447 ± 280 rc_AI232374_g_at H1f0 Histone H1-0 0.00022 1451 ± 142 3066 ± 227 2612 ± 247 rc_AA874802_s_at H1f0 Histone H1-0 0.00009 1525 ± 89 2930 ± 342 2791 ± 70 D16479_at Hadhb TP-beta 0.00010 2649 ± 161 3414 ± 120 3641 ± 119 U18650_at Hdh Huntington disease gene homolog 0.00000 350 ± 22 495 ± 10 524 ± 14 rc_AI007857_at Hgs HGF-regulated tyrosine kinase substrate 0.00226 3536 ± 152 4481 ± 147 4261 ± 177 M13170_at Hist1h1t histone 1, H1t 0.01488 85 ± 11 119 ± 9 122 ± 7 M27433_at Hist4 germinal histone H4 gene 0.00000 280 ± 16 689 ± 44 829 ± 50 rc_AA799893_g_at Hnrpa1 heterogeneous nuclear ribonucleoprotein A1 0.00000 1658 ± 117 2931 ± 79 2974 ± 122 rc_AI104524_s_at Hnrpab heterogeneous nuclear ribonucleoprotein A/B 0.00004 6878 ± 174 9540 ± 333 8546 ± 341 X16933cds_at Hnrpd RNA binding protein p45AUF1 0.00300 1704 ± 69 2220 ± 91 2115 ± 105 AB003726_at Homer1 homer, neuronal immediate early gene, 1 0.00023 1054 ± 50 1295 ± 40 1339 ± 37 AB007690_s_at Homer2 homer, neuronal immediate early gene, 2 0.02231 495 ± 43 667 ± 60 687 ± 42 L16764_s_at Hspa1a heat shock 70kD protein 1A 0.00000 2350 ± 94 3488 ± 108 3743 ± 162 Z27118cds_s_at Hspa1a heat shock 70kD protein 1A 0.00004 504 ± 50 887 ± 39 865 ± 54 Page 2 Supplementary Table 2: Infection-Sensitive Genes Probe Set Symbol Title ANOVA Uninfected Ad-LacZ Ad-aCaN rc_AA800738_at Htatip HIV-1 Tat interactive protein, 60 kD 0.00098 1298 ± 46 1591 ± 91 1670 ± 44 M21410_s_at Htr2c 5-hydroxytryptamine (serotonin) receptor 2C 0.02960 291 ± 17 350 ± 16 355 ± 17 D49395_s_at Htr3a 5-hydroxytryptamine (serotonin) receptor 3a 0.00029 262 ± 28 459 ± 31 400 ± 24 L22558_at Htr7 5-hydroxytryptamine (serotonin) receptor 7 0.00030 385 ± 36 634 ± 49 660 ± 40 rc_AA801286_at Impa1 Inositol (myo)-1(or 4)-monophosphatase 1 0.00001 4756 ± 102 5835 ± 131 5537 ± 112 U20181_at Ireb2 iron-regulatory protein 2 0.00001 1758 ± 64 2430 ± 110 2365 ± 59 rc_AA799537_at Itpr3 inositol 1, 4, 5-triphosphate receptor 3 0.02405 1403 ± 87 1693 ± 93 1713 ± 65 M59980_s_at Kcnd2 potassium voltage gated channel, Shal-related family, member 2 0.00003 528 ± 26 916 ± 65 781 ± 37 AJ003065_at Kcnj14 potassium inwardly-rectifying channel J14 0.00238 209 ± 18 344 ± 25 311 ± 25 L21711_s_at Lgals5 Lectin, galactose binding, soluble 5 (Galectin-5) 0.00005 228 ± 19 529 ± 60 541 ± 38 U72741_g_at Lgals9 Lectin, galactose binding, soluble 9 (Galectin-9) 0.00005 218 ± 36 670 ± 76 665 ± 62 U72353_at Lmnb1 lamin B1 0.00310 94 ± 6 170 ± 17 180 ± 20 rc_AA955808_at LOC171121 protein phosphatase V 0.00852 1928 ± 106 2743 ± 170 2548 ± 187 U49058_at LOC245924 CTD-binding SR-like protein rA4 0.03506 859 ± 40 1027 ± 62 1030 ± 42 U25746_at LOC245957 RNA helicase 0.00001 878 ± 39 1208 ± 64 1254 ± 30 U78090_s_at LOC245960 potassium channel regulator 1 0.00013 1162 ± 64 1870 ± 71 1657 ± 112 rc_H31907_at LOC246185 embryo-related protein 0.00011 742 ± 39 1371 ± 77 1136 ± 94 AF068268_at LOC246268 2'5' oligoadenylate synthetase-2 0.00003 5 ± 1 81 ± 13 96 ± 13 rc_H31287_g_at LOC246273 kinase 0.00000 112 ± 15 498 ± 49 536 ± 35 AB000280_at LOC246280 peptide/histidine transporter 0.01432 799 ± 31 968 ± 52 959 ± 36 AF036335_at LOC252855 NonO/p54nrb homolog 0.00259 1825 ± 130 2532 ± 150 2426 ± 112 rc_AA859305_s_at LOC286890 tropomyosin