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Authors: Pallavi Subhraveti Ron Caspi Peter Midford Peter D Karp An online version of this diagram is available at BioCyc.org. Biosynthetic pathways are positioned in the left of the cytoplasm, degradative pathways on the right, and reactions not assigned to any pathway are in the far right of the cytoplasm. Transporters and membrane proteins are shown on the membrane. Ingrid Keseler Periplasmic (where appropriate) and extracellular reactions and proteins may also be shown. Pathways are colored according to their cellular function. Gcf_000279715Cyc: Streptococcus pneumoniae GA54354 Cellular Overview Connections between pathways are omitted for legibility. Anamika Kothari spermidine D-mannitol putrescine uracil predicted PEP-driven RS09560 RS09150 transporter of D-mannitol spermidine uracil putrescine D-mannitol 1-phosphate Macromolecule Modification Cofactor, Prosthetic Group, Electron Carrier, and Vitamin Biosynthesis Secondary Metabolite queuosine biosynthesis α 5'-deoxy-5'- 4-hydroxy-2- a negatively D-sedoheptulose DNA combined D-ribulose Fatty Acid and Lipid Biosynthesis Degradation a glutaryl-[acp] a (4Z)-hexadec- -D- DHAP [2Fe-2S] iron-sulfur cluster biosynthesis Polymeric Compound Degradation a (6S)-5-formyltetrahydrofolate glu a malonyl-[acp] a purine a malonyl-[acp] 1-phosphate with exogenous thiamine formation from pyrithiamine and oxythiamine (yeast) N 10 -formyl-tetrahydrofolate biosynthesis tetrahydrofolate biosynthesis methyl ester arsenate 4-enoyl-[acp] glucopyranose ATP fluoroadenosine oxoglutarate supercoiled DNA 5-phosphate flavin biosynthesis I (bacteria and plants) thiamine diphosphate lipoate salvage II mannitol ribonucleoside purine-nucleoside fructose- penicillin- beta-ketoacyl- beta-ketoacyl- bifunctional 2-keto- DNA DNA to form a ribulose- biosynthesis III palmitate biosynthesis II (bacteria and plants) preQ bifunctional purine-nucleoside 1-phosphate 0 degradation I phosphorylase: topoisomerase IV: bisphosphate binding protein: phosphate 3- (7,8-dihydropterin- a [lipoyl-carrier acyl-[acyl-carrier protein] glycogen degradation II [acyl-carrier- [acyl-carrier- glucose-1-phosphate 4-hydroxyglutarate recombinationalHolliday junction L-cysteine desulfurase (Staphylococcus) pyrithiamine phosphatidylglycerol chitin degradation II (Vibrio) folylpolyglutamate phosphorylase: a tetrahydrofolate 6 thioesterase pathway adenylyltransferase: CN62_RS07150 aldolase/2- CN62_RS07250 aldolase: junction CN62_RS13160 epimerase: 2-(2-carboxy-4- 6-yl)methyl 4-aminobenzoate protein]-N - biosynthesis II D-mannitol synthase/dihydrofolate protein] protein] resolvase RuvX: GTP CN62_RS07150 CN62_RS04660 diphosphate dihydropteroate lipoyl-L-lysine 1-phosphate synthase II: synthase II: CN62_RS08445 purine-nucleoside keto-3-deoxy-6- CN62_RS07260 glycerol-3- CN62_RS12385 cysteine HMP-PP methylthiazol-5- thiaminase II: an acetoacetyl-[acp] (non-plastidic) a glycogen synthase: CN62_RS04375 CN62_RS04365 an acyl-[acyl- preQ chitin mannitol-1- purine-nucleoside phosphorylase: phosphogluconate phosphate desulfurase: yl)ethylthiamine phosphate synthase: 1 CN62_RS05410 CN62_RS05410 glucose-1-phosphate type I DNA fructose- ribulose- bifunctional CN62_RS06590 DHAP carrier protein] phosphate 5- bifunctional phosphorylase: Holliday junction CN62_RS04835 hypothetical glycogen/ adenylyltransferase CN62_RS07170 aldolase: topoisomerase: bisphosphate dehydrogenase phosphate 3- CN62_RS07345 phosphate 7,8- (R)-lipoate acyl-ACP tRNA folylpolyglutamate 3-oxoacyl-[acyl- 3-oxoacyl-[acyl- resolution ofresolvase RecU: 3,4-dihydroxy- 4-amino-2-methyl-5- glycerol-3- dehydrogenase: CN62_RS07170 5-fluoro-5- CN62_RS04920 (NAD(P)(+)): synthase: protein: thioesterase: starch/alpha- subunit GlgD: CN62_RS09045 aldolase: epimerase: [+ 3 isozymes] 2-butanone- dihydropteroate phosphate guanosine(34) CN62_RS05295 synthase/dihydrofolate carrier-protein] carrier-protein] recombinationalCN62_RS05150 pyrimidinemethanol lipoate-- CN62_RS03855 glucan family ribose-1-arsenate a purine base CN62_RS08450 deoxy-D-ribose adenine CN62_RS06115 CN62_RS13115 CN62_RS10565 CN62_RS06570 CN62_RS09655 transglycosylase synthase: CN62_RS04840 reductase: reductase: pyruvate glyoxylate a relaxed DNA junction an S-sulfanyl-[L- 4-phosphate bifunctional dehydrogenase F6P ADP-α-D-glucose 1-phosphate D-xylulose bifunctional protein ligase: [+ 2 isozymes] a fatty acid phosphorylase: a chitodextrin D-erythrose DHAP sn-glycerol synthase/GTP thiamine folylpolyglutamate (NAD(P)(+)): Tgt: a (6S)-5-formyltetrahydrofolate CN62_RS05405 CN62_RS05405a (6Z)-3- formation of two cysteine desulfurase] hydroxymethylpyrimidine CN62_RS14575 a (3R)-3- CN62_RS13195 a 3-oxopimeloyl- 3-phosphate 5-phosphate cyclohydrolase II: phosphate synthase/ CN62_RS13115 CN62_RS12805 acyl-carrier protein acyl-carrier protein oxooctadec- intact strands kinase/ dihydrofolate hydroxybutanoyl- [acp] methyl ester CN62_RS04200 synthase: dihydrofolate (lipoyl)adenylate a 7-aminomethyl-7- an α-limit dextrin 6-enoyl-[acp] phosphomethylpyrimidine reductase: [acp] penicillin- 34 2,5-diamino-6- CN62_RS06605 synthase: deazaguanosine thiamine kinase: CN62_RS06610 CN62_RS10365 (3R)-3- binding protein: 4-alpha- an S-sulfanyl-[cysteine (5-phospho-D- CN62_RS04375 lipoate-- in tRNA a chitodextrin phosphate hydroxybutanoyl- CN62_RS13160 a glycopeptide- 2251 ribosylamino) hydroxymethylpyrimidine/ protein ligase: tRNA preQ1(34) S- glucanotransferase: a malonyl-[acp] 5'-chloro-5'- (4S)-4-hydroxy- guanosine desulfurase]-[disordered- serine sn-glycerol 4 glycerophosphoserine KDGP 3-ethylmalate acetyl-CoA a 7,8-dihydrofolate a 5-methyltetrahydrofolate bifunctional [acyl-carrier CN62_RS13200 D-mannosyl-N a malonyl-[acp] a purine deoxyadenosine 2-oxoglutarate in 23S rRNA form scaffold pyrimidin- phosphomethylpyrimidine CN62_RS14575 3-phosphate adenosylmethionine methyl ester biotin ATP formate ATP hydroxymethyltransferase: glyA folylpolyglutamate protein] -(N-acetyl-D- glycerophosphodiester ribonucleoside purine-nucleoside bifunctional 2-keto- 23S rRNA 3-isopropylmalate acetyl-CoA 4(3H)-one kinase: CN62_RS10480 a [glycine- ribosyltransferase- a debranched beta-ketoacyl- bifunctional 2-keto- protein] complex oxythiamine purine-nucleoside phosphorylase: dehydrogenase: anaerobic [cysteine desulfurase]-S- synthase/ cleavage complex dehydratase: glycerol-3- α-limit dextrin glucosaminyl) [acyl-carrier- phosphodiesterase: 4-hydroxyglutarate 4-hydroxyglutarate (guanosine(2251) bifunctional biotin- carboxylase bifunctional thymidylate S-adenosyl-L-methionine cycle I isomerase QueA: endo-beta-N- phosphorylase: ribonucleoside- HMP-P dihydrofolate 6 CN62_RS05420 phosphate -asparagine CN62_RS07895 CN62_RS07150 aldolase/2- -2'-O)- -[acetyl-CoA- CN62_RS08990 biotin carboxyl sulfanylcysteine:[acceptor diaminohydroxyphosphoribosylaminopyrimidine thiamine H protein] N - CN62_RS09695 2 protein] aldolase/2- thiaminase II: synthase: beta-N- acetylglucosaminidase: CN62_RS07150 triphosphate protein]-cysteine synthase: acyltransferase: glycogen/ synthase II: glycerophosphodiester keto-3-deoxy-6- purine-nucleoside keto-3-deoxy-6- methyltransferase carboxylase] 3-isopropylmalate carrier protein: deaminase/5-amino-6-(5-phosphoribosylamino) CN62_RS06385 lipoyl-L-lysine a (2E)-but- 34 acetylhexosaminidase: CN62_RS05685 reductase: thiamine CN62_RS06590 bifunctional CN62_RS04840 CN62_RS07245 an epoxyqueuosine purine-nucleoside phosphogluconate RlmB: synthetase/ CN62_RS05415 sulfurtransferase: uracil reductase RibD: CN62_RS04210 SAM starch/alpha- CN62_RS05410 phosphodiesterase: phosphogluconate phosphorylase: dehydrogenase: hydroxymethylpyrimidine hypothetical 2-enoyl-[acp] a 1-acyl-sn in tRNA CN62_RS03670 endo-beta-N- CN62_RS04400 CN62_RS07405 5-amino-6-(5- diphosphokinase: 5-(2-hydroxyethyl) glucan family CN62_RS12140 aldolase: phosphorylase: CN62_RS07170 aldolase: CN62_RS09825 biotin operon CN62_RS09020 [+ 3 isozymes] 7,8-dihydrofolate 3-oxoacyl-[acyl- 2-O- a [cysteine desulfurase]- CN62_RS12380 kinase/ protein: bifunctional a (6S)-5- crotonyl-[acyl- -glycerol 3- D-glucopyranose beta-N- acetylglucosaminidase: CN62_RS07170 5-chloro-5- CN62_RS04920 repressor: dATP phospho-D- -4-methylthiazole monoglutamate phosphorylase: a glycopeptide- sn-glycerol CN62_RS04920 2251 2-oxovalerate malonyl-CoA phosphomethylpyrimidine CN62_RS13955 a [lipoyl-carrier phosphate acetylhexosaminidase: N-acetyl-D-CN62_RS07770 carrier-protein] ser α-D-ribose- methylguanosine S-sulfanyl-[disordered- D-ribulose ribosylamino)uracil methylenetetrahydrofolate formyltetrahydrofolate S-adenosylmethionine carrier-protein] CN62_RS13195 D-mannosyl- 3-phosphate D-glyceraldehyde a purine base adenine deoxyribose CN62_RS11865 thiamine hydroxyethylthiazole methylenetetrahydrofolate protein]-N 6 - reductase: pyruvate 1-phosphate pyruvate glyoxylate in 23S rRNA biotinyl-5'- form scaffold kinase: CN62_RS06610 dehydrogenase/ reductase: 1-acyl-sn-glycerol- CN62_RS13370 4 glucosamine- 5-phosphate bifunctional diphosphate 5-formyltetrahydrofolate synthase: 34 N,N'- N,N',N''- N -N-acetyl- 3-phosphate 1-phosphate kinase: CN62_RS06565 reductase [NAD(P) lipoyl-L-lysine 3-phosphate a queuosine asparagine CN62_RS05405 adenylate protein] complex diaminohydroxyphosphoribosylaminopyrimidine hydroxymethylpyrimidine/ methenyltetrahydrofolate cyclo-ligase: CN62_RS06835 CN62_RS05395 α-D- glucokinase: diacetylchitobiose triacetylchitotriose D-glucosamine cysteine bifunctional hydroxyethylthiazole H]: CN62_RS06045 acyltransferase: in tRNA a 3-oxoglutaryl- deaminase/5-amino-6-(5-phosphoribosylamino) phosphomethylpyrimidine cyclohydrolase: CN62_RS13140