PX88_neu PX82_neu PX71_neu PX7_neu frei_B frei_A PX97 PX96 PX95 PX94 PX93 PX92 PX91 PX89 PX87 PX86 PX85 PX84 PX83 PX81 PX79 PX78 PX77 PX76 PX75 PX74 PX73 PX72 PX69 PX68 PX67 PX66 PX65 PX64 PX63 PX62 PX61 PX59 PX58 PX57 PX56 PX55 PX54 PX53 PX52 PX51 PX49 PX48 PX47 PX46 PX45 PX44 PX43 PX42 PX41 PX39 PX38 PX37 PX36 PX35 PX34 PX33 PX32 PX31 PX29 PX28 PX27 PX26 PX25 PX24 PX23 PX22 PX21 PX19 PX18 PX17 PX16 PX15 PX14 PX13 PX12 PX11 PX9 PX8 PX6 PX5 PX4 PX3 PX2 PX1 PX9 PX8 PX7 PX6 PX5 PX4 PX3 PX2 PX1

Bezeichnung Bezeichnung Wichtigkeithoch1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Wichtigkeithoch Wichtigkeitnormal 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Wichtigkeitnormal Generation1 1 1 1 1 1 1 1 Generation1 Generation2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Generation2 Generation3 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Generation3 Generation4 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Generation4 Generation5 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Generation5 Generation6 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Generation6 Generation7 1 1 1 1 1 1 Generation7 Generationkeine1 1 Generationkeine BruderpaarBruder_PX35 1 1 BruderpaarBruder_PX35 BruderpaarBruder_PX42 1 1 BruderpaarBruder_PX42 BruderpaarBruder_PX46 1 1 BruderpaarBruder_PX46 BruderpaarBruder_PX8 1 1 BruderpaarBruder_PX8 BruderpaarBruder_PX81 1 1 BruderpaarBruder_PX81 BruderpaarBruder_PX89 1 1 BruderpaarBruder_PX89 BruderpaarBruder_PX92 1 1 BruderpaarBruder_PX92 Bruderpaarnein1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Bruderpaarnein AehnlichkeitAehnlich_PX14 1 1 AehnlichkeitAehnlich_PX14 AehnlichkeitAehnlich_PX29 1 1 AehnlichkeitAehnlich_PX29 AehnlichkeitAehnlich_PX3 1 1 AehnlichkeitAehnlich_PX3 AehnlichkeitAehnlich_PX32 1 1 AehnlichkeitAehnlich_PX32 AehnlichkeitAehnlich_PX34 1 1 AehnlichkeitAehnlich_PX34 AehnlichkeitAehnlich_PX41 1 1 1 1 AehnlichkeitAehnlich_PX41 AehnlichkeitAehnlich_PX431 1 AehnlichkeitAehnlich_PX43 AehnlichkeitAehnlich_PX441 1 AehnlichkeitAehnlich_PX44 AehnlichkeitAehnlich_PX45 1 1 AehnlichkeitAehnlich_PX45 AehnlichkeitAehnlich_PX46 1 1 1 1 AehnlichkeitAehnlich_PX46 AehnlichkeitAehnlich_PX47 1 1 1 AehnlichkeitAehnlich_PX47 AehnlichkeitAehnlich_PX53 1 1 1 1 AehnlichkeitAehnlich_PX53 AehnlichkeitAehnlich_PX54 1 1 AehnlichkeitAehnlich_PX54 AehnlichkeitAehnlich_PX58 1 1 AehnlichkeitAehnlich_PX58 AehnlichkeitAehnlich_PX63 1 1 1 AehnlichkeitAehnlich_PX63 AehnlichkeitAehnlich_PX73 1 1 AehnlichkeitAehnlich_PX73 AehnlichkeitAehnlich_PX771 1 1 AehnlichkeitAehnlich_PX77 Aehnlichkeitnein 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Aehnlichkeitnein Groessegross 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Groessegross Groesseklein 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Groesseklein Groessemittel 1 1 1 1 1 1 1 1 1 1 Groessemittel Groesseriesig1 1 1 1 Groesseriesig Haptikhart1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Haptikhart Haptikweich 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Haptikweich Position_allgemeinhaengt1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Position_allgemeinhaengt Position_allgemeinsteht1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Position_allgemeinsteht Position_detailhaengt_mit_Abstand1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Position_detailhaengt_mit_Abstand Position_detailhaengt_ohne_Abstand1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Position_detailhaengt_ohne_Abstand Position_detailsteht1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Position_detailsteht MaterialBeton 1 1 1 1 MaterialBeton MaterialGips 1 1 1 1 1 1 1 1 1 1 1 1 1 MaterialGips MaterialKunstleder 1 1 1 1 1 1 MaterialKunstleder MaterialPapierpaste 1 1 1 1 MaterialPapierpaste MaterialPaste1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 MaterialPaste MaterialPlastik 1 1 1 1 1 MaterialPlastik MaterialPolyester1 1 MaterialPolyester MaterialSilikon 1 1 1 1 1 1 1 1 1 1 MaterialSilikon Aufbauabgegossen 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Aufbauabgegossen Aufbaugebaut1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Aufbaugebaut Aufbaugenaeht 1 1 1 1 1 1 1 1 1 1 1 Aufbaugenaeht Aufbaulaminiert 1 Aufbaulaminiert Aufbau_detailabgegossen 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Aufbau_detailabgegossen Aufbau_detailgebaut1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Aufbau_detailgebaut Aufbau_detailgebaut_gefuellt 1 Aufbau_detailgebaut_gefuellt Aufbau_detailgenaeht_gefuellt 1 1 1 1 Aufbau_detailgenaeht_gefuellt Aufbau_detailgenaeht_hohl 1 1 1 1 1 1 1 Aufbau_detailgenaeht_hohl Aufbau_detaillaminiert_gefuellt 1 Aufbau_detaillaminiert_gefuellt Farbeblau 1 1 1 1 1 1 1 1 Farbeblau Farbebunt 1 Farbebunt FarbeFarbe_X 1 1 FarbeFarbe_X Farbegelb 1 1 1 1 1 1 1 Farbegelb Farbegrau 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Farbegrau Farbegruen 1 Farbegruen Farbegrün 1 Farbegrün Farbehellgruen 1 Farbehellgruen Farbemilch 1 1 Farbemilch Farbeorange.rot1 1 1 1 1 1 1 1 Farbeorange.rot Farberosa 1 Farberosa Farberot 1 1 Farberot Farbeschwarz 1 1 1 1 1 Farbeschwarz Farbeunbekannt 1 1 1 1 1 Farbeunbekannt Farbeweiss1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Farbeweiss Farbbasisfabric 1 1 1 1 1 1 1 1 1 1 1 1 Farbbasisfabric FarbbasisFarbauftrag1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 FarbbasisFarbauftrag FarbbasisMaterialfarbe 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 FarbbasisMaterialfarbe FarbbasisMetallbeine 1 1 1 1 FarbbasisMetallbeine FarbbasisPU.gruen 1 1 FarbbasisPU.gruen FarbbasisSilikon.gruen 1 FarbbasisSilikon.gruen Farbbasisunbekannt 1 1 1 1 Farbbasisunbekannt Farbkombinationblau.orange 1 1 Farbkombinationblau.orange Farbkombinationgelb.weiss 1 1 Farbkombinationgelb.weiss Farbkombinationgrau.gruen 1 1 Farbkombinationgrau.gruen Farbkombinationgrau.milch 1 Farbkombinationgrau.milch Farbkombinationgrau.weiss 1 Farbkombinationgrau.weiss Farbkombinationnein1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Farbkombinationnein Farbkombinationweiss.milch 1 1 1 Farbkombinationweiss.milch Zweites_MaterialHolzkiste 1 1 Zweites_MaterialHolzkiste Zweites_Materialnein1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Zweites_Materialnein Zweites_MaterialPlexiglas 1 1 1 Zweites_MaterialPlexiglas Zweites_MaterialPVC.Folie1 Zweites_MaterialPVC.Folie Einsatz_allgemeineinfach1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Einsatz_allgemeineinfach Einsatz_allgemeinnein1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Einsatz_allgemeinnein Einsatz_detail1Einsatz_Ausguss 1 1 1 1 1 Einsatz_detail1Einsatz_Ausguss Einsatz_detail1Einsatz_Glaslinse 1 1 Einsatz_detail1Einsatz_Glaslinse Einsatz_detail1Einsatz_M1 1 Einsatz_detail1Einsatz_M1 Einsatz_detail1Einsatz_M2 1 Einsatz_detail1Einsatz_M2 Einsatz_detail1Einsatz_M3 1 Einsatz_detail1Einsatz_M3 Einsatz_detail1Einsatz_M4 1 Einsatz_detail1Einsatz_M4 Einsatz_detail1Einsatz_Noppen 1 1 Einsatz_detail1Einsatz_Noppen Einsatz_detail1Einsatz_Schlauch 1 1 Einsatz_detail1Einsatz_Schlauch Einsatz_detail1Einsatz_Staender 1 1 Einsatz_detail1Einsatz_Staender 1 1 Einsatz_detail1Einsatz_Ventil1 1 Einsatz_detail1Einsatz_Ventil 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Einsatz_detail1nein1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Einsatz_detail1nein Einsatz_detail2Einsatz_Glas 1 1 Einsatz_detail2Einsatz_Glas Einsatz_detail2Einsatz_Metall1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Einsatz_detail2Einsatz_Metall Einsatz_detail2Einsatz_Mutation 1 1 1 1 Einsatz_detail2Einsatz_Mutation Einsatz_detail2Einsatz_NA 1 Einsatz_detail2Einsatz_NA 1 1 Einsatz_detail2Einsatz_Plastik 1 Einsatz_detail2Einsatz_Plastik Einsatz_detail2Einsatz_Schaumgummi 1 1 Einsatz_detail2Einsatz_Schaumgummi 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Einsatz_detail2nein1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Einsatz_detail2nein 1 1 1 IronieIronie1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 IronieIronie Ironienein1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Ironienein 1 1 1 1 1 1 1 1 Biomorphbiomorph 1 1 Biomorphbiomorph 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Biomorphnein1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Biomorphnein 1 Biomorph_detailbiomorph_andere 1 1 1 Biomorph_detailbiomorph_andere Biomorph_detailbiomorph_tailliert 1 1 1 1 1 1 Biomorph_detailbiomorph_tailliert 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Biomorph_detailnein1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Biomorph_detailnein Schnorchel_allgemeinnein1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Schnorchel_allgemeinnein Schnorchel_allgemeinSchorchel 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Schnorchel_allgemeinSchorchel 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Schnorchel_detail1nein1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Schnorchel_detail1nein 1 1 1 Schnorchel_detail1Schnorchel_schmal 1 1 1 1 1 1 Schnorchel_detail1Schnorchel_schmal Schnorchel_detail1Schnorchel_Variation 1 1 1 1 1 1 1 1 Schnorchel_detail1Schnorchel_Variation Schnorchel_detail2nein1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Schnorchel_detail2nein Schnorchel_detail2Schnorchel_Aufsatz 1 1 Schnorchel_detail2Schnorchel_Aufsatz Schnorchel_detail2Schnorchel_Metall 1 Schnorchel_detail2Schnorchel_Metall Schnorchel_detail2Schnorchel_rund 1 1 1 1 Schnorchel_detail2Schnorchel_rund 1 1 1 Schnorchel_detail2Schnorchel_schmal 1 1 1 1 1 1 Schnorchel_detail2Schnorchel_schmal 1 1 1 1 1 DUO_GruppeDuo 1 1 1 1 1 DUO_GruppeDuo DUO_GruppeGruppe1 1 1 1 1 1 DUO_GruppeGruppe 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 DUO_Gruppesingle1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 DUO_Gruppesingle 1 1 1 1 1 1 1 1 1 Oeffnung_allgemeingeschlossene_Form1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Oeffnung_allgemeingeschlossene_Form Oeffnung_allgemeinHuelle 1 1 1 1 1 1 1 1 1 1 1 1 Oeffnung_allgemeinHuelle 1 Oeffnung_allgemeinMutationA Research Report 2013 Oeffnung_allgemeinMutationA Oeffnung_allgemeinMutationB 1 Oeffnung_allgemeinMutationB 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Oeffnung_detailgeschlossene_Form1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Oeffnung_detailgeschlossene_Form 1 1 Oeffnung_detailHuelle_gefuellt 1 1 1 Oeffnung_detailHuelle_gefuellt Oeffnung_detailHuelle_leer 1 1 1 1 1 1 1 Oeffnung_detailHuelle_leer Oeffnung_detailMutationA 1 Oeffnung_detailMutationA Oeffnung_detailMutationB 1 Oeffnung_detailMutationB Formmerkmal2_Spoiler 1 1 1 1 Formmerkmal2_Spoiler FormmerkmalHoehle 1 1 FormmerkmalHoehle FormmerkmalKombination 1 FormmerkmalKombination 1 1 1 1 FormmerkmalLoch 1 FormmerkmalLoch 1 1 1 1 1 Formmerkmalmittiger_Einsatz1 1 1 1 1 Formmerkmalmittiger_Einsatz 1 1 1 1 1 1 1 1 1 1 1 1 1 Formmerkmalnein1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Formmerkmalnein FormmerkmalVertiefung 1 1 1 1 1 1 1 FormmerkmalVertiefung 1 1 HalbkugelHalbkugel 1 1 1 1 1 1 1 1 1 1 1 1 1 HalbkugelHalbkugel 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Halbkugelnein1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Halbkugelnein 1 Gereihteinfach 1 1 1 1 1 1 1 1 1 Gereihteinfach 1 Gereihtgereiht 1 1 1 1 Gereihtgereiht 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Gereihtnein1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Gereihtnein 1 1 Konvexkonvex 1 1 1 1 1 1 1 1 1 1 1 1 1 Konvexkonvex 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Konvexnein1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Konvexnein Konkavkonkav 1 1 1 1 Konkavkonkav 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Konkavnein1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Konkavnein 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Voluminoesflach1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Voluminoesflach 1 1 1 1 1 Voluminoesflach.voluminoes 1 1 1 1 1 1 1 1 Voluminoesflach.voluminoes 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Voluminoesvoluminoes1 1 1 1 1 1 1 1 1 1 1 1 1 1 Voluminoesvoluminoes 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Oberflaecheglatt1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Oberflaecheglatt 1 1 1 Oberflaechestruktur 1 1 1 1 1 1 Oberflaechestruktur StrukturMuta1 1 StrukturMuta1 StrukturMuta2 1 StrukturMuta2 StrukturMuta3 1 StrukturMuta3 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Strukturnein1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Strukturnein StrukturNoppen 1 1 1 1 StrukturNoppen StrukturRillen 1 1 StrukturRillen Sockelnein1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Sockelnein SockelSockel 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 SockelSockel BeineBeine1 1 1 1 1 1 1 1 1 BeineBeine Beinenein1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Beinenein Zusatztitelja1 1 1 1 1 1 1 1 1 1 Zusatztitelja Zusatztitelnein 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Zusatztitelnein 0 4,6904 4,8990 5,0990 6 6,1644 5,0990 4,6904 5,0990 4,4721 5,2915 4,8990 5,0990 6 5,2915 6,7823 6,4807 6,3246 6,6332 6,6332 5,8310 6,4807 6,4807 6,1644 4,2426 5,0990 4 3,7417 4,8990 5,0990 5,4772 4,6904 6,1644 4,4721 6,3246 6,3246 6,1644 5,8310 5,6569 6,3246 6,6332 6,3246 4,4721 4 4,6904 4,8990 4,8990 4,8990 5,2915 5,2915 5,0990 4,8990 5,6569 5,2915 5,0990 6 6,3246 7,4833 6,3246 6 6,4807 6,7823 6,4807 4,5826 5,1962 5 5,2915 5,2915 5,0990 5,6569 5,4772 6,9282 6,4807 6,6332 6,6332 6,4807 6,5574 5,7446 4,5826 5,6569 5,6569 5,6569 5,6569 5,4772 5,0990 5,4772 6,1644 6 6,4807 6,7823 5,3852 5,4772 5,0990 5,8310 6,1644 6,0000 5,5678 5,5678 5 4,6904 0 4,2426 4,2426 5,4772 5,6569 4,2426 4 4,2426 4,4721 4,6904 4,4721 4,4721 4,8990 4,8990 6 5,8310 5,4772 5,6569 6 5,0990 5,4772 6 5,4772 3,1623 4 4,4721 5,0990 4,8990 4,4721 4,4721 4,2426 5,0990 4 5,6569 5,6569 5,4772 5,0990 5,0990 5,2915 5,8310 5,6569 4,6904 4,4721 4,4721 4,8990 4,4721 4 4,2426 4,6904 4,8990 4,4721 4,2426 4,2426 4,2426 5,0990 5,2915 6,6332 5,2915 5,6569 5,8310 5,8310 6 4,7958 4,5826 4,5826 5,2915 5,0990 4 4,8990 4,6904 6,3246 5,2915 6 6 6,1644 5,9161 5,7446 4,3589 5,0990 5,0990 5,2915 4,6904 4,2426 4,4721 4,4721 4,8990 5,0990 5,8310 6 4,7958 4,8990 5,2915 4,8990 4,6904 4,4721 4,7958 4,3589 4,5826 4,8990 4,2426 0 4,4721 5,0990 5,0990 4 4,2426 4,2426 4,4721 2 3,1623 4 4,8990 5,0990 5,8310 6 5,2915 5,8310 5,8310 4,8990 5,2915 5,6569 5,2915 4,6904 3,7417 4,4721 4,2426 4 3,1623 3,7417 4,4721 4,6904 4 5,4772 5,4772 5,6569 4,6904 4,8990 5,4772 5,6569 5,2915 4,8990 4,6904 4 5,0990 4,8990 4,2426 4,8990 5,0990 4,4721 4 3,7417 4,6904 5,0990 4,6904 6 6,6332 5,6569 4,8990 5,2915 6 5,4772 4,5826 4,7958 4,5826 5,8310 5,6569 4,8990 4 4,8990 6 5,8310 5,4772 5,6569 5,8310 5,5678 5,5678 5,3852 5,4772 5,2915 5,2915 4,2426 4 5,4772 4,2426 5,4772 5,0990 5,6569 5,8310 4,5826 5,0990 5,2915 4,6904 5,4772 5,2915 4,7958 4,7958 4,7958 5,0990 4,2426 4,4721 0 5,0990 5,0990 3,1623 4,4721 4,4721 5,0990 4,8990 4,8990 4,4721 4,4721 2,8284 5,8310 6 5,4772 5,8310 5,8310 4,2426 4,8990 5,4772 4,6904 4,6904 4,8990 5,2915 CeMM5,4772 Research5,6569 5,0990 Report5,2915 20134,6904 4,6904 4,6904 5,4772 5,4772 5,6569 3,7417 4,8990 4,8990 5,2915 4,8990 5,0990 4,8990 5,0990 6 5,8310 5,0990 4,6904 5,2915 4,8990 5,4772 5,4772 5,4772 4,6904 3,7417 5,0990 6,7823 6 4,6904 4,8990 5,6569 5,4772 5 5,1962 4,7958 6,1644 5,8310 4,8990 5,6569 5,6569 5,6569 5,6569 5,6569 5,2915 5,4772 5,5678 6,2450 5,1962 6 6,1644 6,1644 5,4772 5,2915 5,6569 5,2915 5,8310 5,8310 5,2915 5,4772 5,5678 6 6,1644 5,6569 5,8310 5,6569 5,7446 5,1962 5 6 5,4772 5,0990 5,0990 0 2,8284 4,4721 5,4772 5,8310 6 5,4772 5,2915 5,0990 5,4772 5,6569 4,2426 4 4,4721 4 4 4,6904 5,2915 5,6569 5,0990 5,8310 5,2915 5,6569 5,8310 6 5,6569 5,6569 5,8310 5,6569 5,8310 4,4721 4,4721 3,7417 5,2915 4,6904 5,0990 5,4772 5,0990 6,1644 6 5,4772 6,3246 6,1644 5,4772 5,8310 5,8310 5,6569 5,8310 5,8310 6,4807 6 5,4772 4,2426 4,8990 5,6569 4,6904 4,8990 5,2915 4,8990 5,3852 6,0828 5,3852 6,9282 6,6332 5,8310 6 6,1644 5,6569 6,1644 5,6569 5,0990 5,6569 5,5678 6,5574 6,4031 5,6569 6 6 5,0990 5,0990 6 5,0990 6,3246 5,4772 5,0990 5,0990 5,1962 5,8310 6 5,2915 6,1644 6 5,3852 6,0828 5,7446 6,1644 5,6569 5,0990 5,0990 2,8284 0 4,6904 5,6569 5,8310 6,1644 5,4772 5,4772 5,2915 5,6569 5,6569 3,4641 3,4641 4,8990 3,4641 3,4641 4,8990 5,2915 5,8310 5,2915 6 5,4772 5,8310 6 6,1644 5,6569 5,8310 6 5,8310 6 4,2426 4,2426 4,6904 5,2915 4,8990 5,2915 5,6569 4,8990 6,3246 6,1644 5,6569 6,4807 6,3246 5,6569 6 6 5,6569 6 6 6,6332 6,1644 5,4772 5,0990 5,4772 5,8310 4,8990 4,8990 5,2915 5,2915 5,5678 6,2450 5,5678 7,0711 6,7823 6 6,1644 6,3246 5,8310 6,3246 5,6569 5,2915 5,8310 5,7446 6,7082 6,5574 5,8310 6,1644 6,1644 5,4772 5,2915 6,1644 5,2915 6,4807 5,8310 5,0990 5,2915 5,3852 6 6,1644 5,2915 6,3246 6,1644 5,5678 6,2450 6,0828 5,0990 4,2426 4 3,1623 4,4721 4,6904 0 4,4721 4,8990 4,8990 4,4721 4,2426 3,7417 3,1623 4 5,4772 5,2915 4,8990 5,0990 5,0990 2,8284 4,4721 4,6904 3,4641 4,8990 4,2426 4,6904 4,8990 5,0990 4,6904 4,6904 4,8990 3,4641 4,6904 4,8990 4,8990 5,0990 3,4641 4,2426 3,7417 4,2426 4,4721 5,2915 5,0990 4,2426 5,4772 5,0990 4,2426 4,6904 5,2915 4,4721 4,6904 4,8990 5,6569 4,6904 3,7417 5,4772 6,3246 5,6569 4 4,4721 5,0990 4,6904 4,1231 5 3,8730 6 5,6569 4,6904 5,0990 5,6569 5,0990 5,4772 4,8990 4,6904 4,4721 4,7958 5,5678 5,3852 5,2915 5,4772 5,6569 4,8990 4,4721 5,4772 4,6904 5,8310 5,2915 4,6904 4,8990 5 5,2915 5,6569 5,0990 5,6569 5,4772 5,1962 5 5 4,6904 4 4,2426 4,4721 5,4772 5,6569 4,4721 0 2,4495 4 3,7417 3,4641 3,4641 4,6904 4,2426 5,6569 5,6569 5,0990 5,4772 5,4772 4,4721 5,2915 5,2915 4,8990 4,2426 3,7417 4,6904 4,4721 5,0990 4,2426 4,2426 3,7417 5,0990 4,2426 5,0990 5,0990 5,4772 4,6904 4,6904 5,2915 5,6569 5,0990 4,2426 4,2426 4 4,8990 5,0990 4 4 4,4721 4,6904 4,4721 4,4721 4,6904 4,4721 4,8990 5,2915 6,6332 5,2915 5,0990 5,8310 5,8310 5,4772 4,7958 5 4,7958 5,6569 5,6569 4,2426 4,6904 4,8990 6,3246 5,4772 5,4772 6 6,1644 5,3852 5,9161 4,5826 5,2915 5,0990 5,0990 4,4721 4,6904 4,8990 4,2426 5,0990 5,2915 5,8310 5,6569 4,3589 5,2915 5,4772 4,8990 5,0990 5,2915 5,1962 4,7958 4,5826 5,0990 4,2426 4,2426 4,4721 5,8310 5,8310 4,8990 2,4495 0 4 3,7417 3,4641 4 5,0990 4,2426 5,8310 6 5,0990 5,8310 5,8310 4,8990 5,2915 5,6569 5,2915 4,4721 4,0000 5,0990 4,8990 5,2915 4,2426 4,4721 3,7417 5,4772 4,2426 5,4772 5,4772 5,8310 4,8990 5,0990 5,6569 6 5,2915 4,6904 4,6904 4,4721 5,2915 5,4772 4,4721 4,2426 4,4721 4,6904 4,6904 4,6904 4,2426 4,4721 4,6904 5,4772 6,9282 5,4772 5,2915 5,8310 6,1644 5,8310 5,1962 5 5,1962 5,4772 5,6569 4,2426 4,8990 4,4721 6,6332 5,2915 5,8310 6,3246 6,4807 5,9161 6,2450 4,7958 5,6569 5,4772 5,4772 4,6904 4,8990 4,8990 4,2426 4,8990 5,6569 6,1644 6 5 5,6569 5,8310 5,4772 4,6904 4,8990 5,5678 4,7958 5,0000 4,4721 4,4721 4,4721 5,0990 6 6,1644 4,8990 4 4 0 4 3,7417 4,2426 5,0990 4,8990 6,1644 6 5,6569 5,8310 5,8310 4,8990 5,8310 5,8310 5,2915 4,8990 4,4721 4,4721 Science3,4641 4,2426 4,4721 4,4721 4,2426 5,0990 4 5,8310 5,8310 6 5,2915 5,2915 5,6569 6 5,8310 5,2915 5,0990 4,4721 4,8990 4,8990 4,4721 4,4721 4,6904 4,4721 3,4641 4,6904 4,6904 4,6904 5,2915 5,8310 7,0711 5,6569 5,6569 6,3246 6,3246 6 5,1962 4,5826 5,1962 4,6904 4,8990 4,2426 4,6904 4,6904 6,7823 5,8310 6,1644 6,4807 6,4807 6,0828 6,2450 5 4,8990 4,8990 5,0990 5,0990 5,0990 3,7417 4,8990 5,4772 5,8310 6,4807 6,3246 5,1962 5,0990 5,4772 5,6569 5,0990 5,2915 5,7446 4,7958 5,3852 5,2915 4,6904 2 4,8990 5,4772 5,4772 4,4721 3,7417 3,7417 4 0 2,4495 3,4641 4,4721 4,6904 5,4772 5,6569 4,8990 5,4772 5,4772 4,4721 4,8990 5,2915 4,8990 4,8990 3,4641 4,6904 4 4,2426 2,8284 3,4641 4,2426 4,4721 4,2426 5,2915 5,2915 5,4772 4,4721 4,6904 5,2915 5,4772 5,0990 5,0990 4,8990 3,7417 4,8990 5,0990 4 4,6904 4,8990 4,2426 3,7417 3,4641 4,4721 4,8990 4,4721 5,8310 6,4807 5,4772 4,6904 5,4772 5,8310 5,2915 4,7958 5 4,7958 5,6569 5,8310 4,6904 3,7417 4,6904 6,1644 5,6569 5,2915 5,8310 6 5,3852 5,7446 5,1962 5,2915 5,0990 5,0990 4 4,2426 5,2915 4 5,2915 5,2915 5,8310 5,6569 4,3589 5,2915 5,4772 4,8990 5,2915 5,4772 5 5 5 4,8990 4,4721 3,1623 4,8990 5,2915 5,4772 4,2426 3,4641 3,4641 3,7417 2,4495 0 3,1623 4,4721 4,6904 5,4772 5,4772 4,4721 5,2915 5,2915 4,2426 4,8990 5,0990 4,6904 4,6904 3,1623 4,4721 3,4641 4,2426 3,1623 3,1623 4,2426 4,4721 4,2426 5,0990 5,0990 5,2915 4,4721 4,2426 5,0990 5,4772 5,0990 5,0990 4,8990 3,7417 4,6904 5,0990 3,7417 4,4721 4,8990 4,2426 3,4641 3,4641 4,2426 4,8990 4,4721 5,6569 6,4807 5,2915 4,4721 5,4772 5,6569 5,2915 4,5826 4,7958 4,5826 5,6569 5,8310 4,4721 3,7417 4,4721 6,1644 5,4772 5,2915 5,8310 6 5,3852 5,7446 5 5,0990 5,0990 5,0990 4 4,2426 5,0990 3,4641 5,0990 5,0990 5,6569 5,6569 4,3589 5,2915 5,2915 4,8990 4,8990 5,0990 5 5 5 pp. 2—5 5,0990 4,4721 4 4,4721 5,0990 5,2915 3,7417 3,4641 4 4,2426 3,4641 3,1623 0 3,4641 4,2426 4,8990 5,2915 4,6904 5,0990 4,6904 3,7417 4,6904 5,0990 4,2426 4,6904 3,4641 4,2426 Director’s4,2426 4,8990 4 Intro3,4641 4 4 4,6904 4,8990 4,8990 5,0990 3,4641 4 4,6904 5,0990 4,8990 5,0990 4,8990 3,7417 4,8990 5,0990 3,7417 4 4,6904 4 4,2426 4 5,0990 4,4721 4,2426 5,2915 6,3246 5,2915 4,4721 5,2915 5,4772 5,2915 4,3589 5 4,1231 5,6569 5,6569 4,2426 4,4721 5,2915 5,8310 5,4772 5,4772 5,4772 5,2915 5,3852 5,1962 4,5826 4,8990 5,0990 5,0990 4,2426 4,4721 5,0990 4 5,4772 5,0990 5,4772 5,2915 4,3589 5,2915 5,4772 4,4721 5,2915 5,4772 5 4,7958 4,7958 6 4,8990 4,8990 4,4721 5,4772 5,6569 3,1623 4,6904 5,0990 5,0990 4,4721 4,4721 3,4641 0 4,2426 4,8990 5,0990 5,0990 4,8990 4,8990 3,1623 4,4721 4,8990 3,7417 5,2915 4,2426 5,0990 5,2915 5,2915 4,6904 4,4721 5,0990 2 5,2915 5,2915 5,2915 5,0990 3,1623 4,4721 3,7417 4,2426 4,6904 5,8310 5,6569 4,4721 5,2915 5,2915 4,2426 4,8990 5,2915 4,4721 4,6904 4,6904 5,4772 4,8990 4 5,2915 6,3246 5,6569 4,4721 5,0990 5,0990 4,8990 5 5,7446 4,7958 5,8310 6 4,6904 4,8990 5,4772 5,4772 5,2915 5,0990 5,0990 4,6904 4,7958 5,7446 5,3852 5,2915 5,2915 5,4772 4,6904 4,6904 5,4772 4,6904 5,6569 5,6569 4,8990 4,6904 4,7958 5,4772 5,8310 4,8990 5,6569 5,8310 5,3852 5,3852 5,3852 pp. 20—27 5,2915 4,8990 5,0990 2,8284 5,6569 5,6569 4 4,2426 4,2426 4,8990 4,6904 4,6904 4,2426 4,2426 0 5,6569 5,4772 5,2915 5,6569 5,6569 4 4,6904 5,2915 4,4721 5,0990 4,8990 5,2915 Discussion5,0990 6 4,6904 on 5,2915Art 4,2426and 4,6904Science4,6904 5,4772 5,4772 5,2915 3,7417 4,8990 4,8990 5,2915 4,8990 5,0990 4,8990 5,0990 5,6569 5,8310 4,6904 4,6904 4,8990 4,8990 5,4772 5,4772 5,0990 4,2426 3,7417 5,0990 6,7823 6 4,6904 5,2915 5,6569 5,4772 5 5,5678 5,1962 5,8310 5,8310 4,4721 5,6569 5,2915 6 5,6569 5,6569 5,6569 5,4772 5,5678 6,2450 4,7958 6 6,1644 6,1644 5,4772 5,6569 5,6569 5,2915 5,8310 6,1644 5,6569 5,4772 5,1962 6,3246 6,1644 6 5,8310 6 5,7446 5,5678 5 6,7823 6 5,8310 5,8310 4,2426 3,4641 5,4772 5,6569 5,8310 6,1644 5,4772 5,4772 4,8990 4,8990 5,6569 0 3,1623 4,8990 2,4495 2,4495 4,8990 5,0990 5,8310 5,2915 6,1644 5,2915 6 6,1644 6,3246 5,4772 5,4772 6,1644 5,2915 6,4807 4,2426 4,2426 4,6904 4,8990 4,8990 5,0990 5,6569 4,8990 6,7823 6,6332 5,8310 6,3246 6,4807 5,4772 6 6 5,4772 5,8310 5,8310 6,4807 6,3246 5,4772 4,8990 5,6569 5,6569 5,0990 5,2915 5,0990 5,4772 6,0828 6,7082 6,0828 6,9282 7,0711 5,8310 6 6,1644 6,1644 6,1644 5,6569 5,6569 6 5,7446 6,8557 6,4031 5,6569 6 6 5,2915 5,4772 6 5,0990 6,3246 6 5,2915 5,0990 5,1962 6,1644 6,3246 5,0990 6,1644 6,3246 5,7446 6,5574 6,4031 pp. 28—53 6,4807 5,8310 6 6 4 3,4641 5,2915 5,6569 6 6,0000 5,6569 5,4772 5,2915 5,0990 5,4772 3,1623 0 4,8990 2 2,8284 4,6904 5,2915 5,8310 5,0990 6,1644 5,2915 5,6569 Science5,8310 6,3246 at5,2915 CeMM5,6569 5,8310 5,4772 6 4,4721 4,4721 4 5,4772 4,8990 4,8990 5,4772 5,0990 6,4807 6,3246 5,6569 6 6 4,8990 6 5,6569 5,6569 5,6569 5,8310 6,1644 5,8310 5,6569 4,8990 5,4772 5,4772 5,0990 5,4772 5,0990 5,4772 5,5678 6,5574 5,9161 6,4807 6,6332 5,2915 6 5,6569 6,1644 6 5,6569 5,6569 5,8310 5,7446 6,7082 6,2450 5,4772 5,8310 6 5,2915 5,2915 5,8310 5,0990 6,1644 6 5,2915 5,0990 4,7958 6 6 5,4772 6 6,1644 5,3852 6,5574 6,2450 6,3246 5,4772 5,2915 5,4772 4,4721 4,8990 4,8990 5,0990 5,0990 5,6569 4,8990 4,4721 4,6904 5,0990 5,2915 4,8990 4,8990 0 4,6904 4,6904 4,8990 4,2426 5,8310 5,2915 6 4,8990 5,8310 5,6569 6 5,2915 5,2915 5,6569 5,4772 6 4,2426 4,2426 4,2426 5,0990 5,2915 5,6569 6 5,6569 6,3246 6,1644 5,2915 5,8310 6 5,2915 5,6569 6,1644 5,2915 5,4772 5,0990 5,6569 5,4772 5,0990 4,8990 5,4772 6 4,8990 5,6569 5,6569 5,6569 5,5678 6,0828 5,3852 6,4807 6,6332 5,6569 5,6569 6,1644 6,3246 6,3246 6 6 6,4807 6,0828 6,5574 5,9161 6 6,1644 6,1644 5,4772 5,6569 6,1644 5,0990 6,3246 6,3246 6 5,8310 5,7446 6,3246 6,4807 6,1644 6 6,1644 6,0828 6,0828 5,7446 pp. 30—35 6,6332 5,6569 5,8310 5,8310 4 3,4641 5,0990 5,4772 5,8310 5,8310 5,4772 5,2915 5,0990 4,8990 5,6569 2,4495 2,0000 4,6904 0 2 4,4721 5,0990 5,6569 4,8990 6 5,0990 5,8310 Cancer6 6,1644 5,4772 5,4772 6 5,2915 6,1644 4 4 4,4721 5,2915 4,6904 4,6904 5,2915 4,8990 6,6332 6,4807 5,4772 6,1644 6,1644 5,0990 5,8310 5,8310 5,4772 5,4772 5,6569 6,3246 6 5,4772 4,8990 5,4772 5,2915 4,8990 5,2915 4,8990 5,2915 5,7446 6,4031 5,7446 6,6332 6,7823 5,4772 5,8310 5,8310 6 5,8310 5,4772 5,4772 6,0000 5,5678 6,8557 6,4031 5,2915 5,6569 5,8310 5,0990 5,0990 5,6569 4,8990 6 5,8310 5,0990 4,8990 5 5,8310 6,1644 5,2915 5,8310 6 5,5678 6,4031 6,4031 6,6332 6 5,8310 5,8310 4 3,4641 5,0990 5,4772 5,8310 5,8310 5,4772 5,2915 4,6904 4,8990 5,6569 2,4495 2,8284 4,6904 2 0 4,4721 5,2915 5,6569 4,8990 6,3246 5,4772 6,1644 6 6,4807 5,8310 5,6569 6 5,2915 6,1644 4 4 4,8990 5,0990 4,8990 5,0990 5,4772 5,0990 6,6332 6,4807 5,4772 6,4807 6,4807 5,4772 5,6569 5,6569 5,8310 5,8310 6 6,6332 6 5,6569 5,0990 5,6569 5,6569 4,8990 5,4772 5,2915 5,2915 5,7446 6,4031 5,7446 6,9282 6,9282 5,8310 6,1644 6,1644 6,1644 6,1644 5,6569 5,6569 5,6569 5,7446 6,5574 6,0828 5,6569 6 6,1644 5,4772 5,4772 6 5,2915 6,3246 6,1644 5,4772 5,2915 5,3852 6,1644 6,4807 5,2915 6,1644 6,3246 5,9161 6,2450 6,2450 pp. 36—39 5,8310 5,0990 4,8990 4,2426 4,6904 4,8990 2,8284 4,4721 4,8990 4,8990 4,4721 4,2426 3,7417 3,1623 4 4,8990 4,6904 4,8990 4,4721 4,4721 0 4,4721 3,7417 2 5,4772 4,4721 5,2915 Infectious5,0990 5,6569 4,8990 Diseases4,8990 5,0990 3,7417 5,2915 5,0990 5,0990 5,2915 3,7417 3,7417 3,1623 3,7417 4 5,8310 5,6569 4,4721 5,6569 5,6569 4,4721 4,8990 4,6904 4,6904 4,8990 5,0990 5,8310 4,8990 4 5,6569 5,8310 5,2915 3,1623 4,4721 4,6904 4,2426 4,7958 5,5678 4,5826 6,1644 6,1644 4,8990 5,2915 5,0990 4,8990 5,0990 4,4721 4,6904 4,4721 4,3589 6,0828 5,5678 4,8990 4,8990 5,0990 4,2426 4,2426 4,8990 4,0000 5,2915 5,0990 4,6904 4,4721 4,5826 5,0990 5,4772 5,0990 5,0990 5,2915 5,1962 5,5678 5,5678 6,4807 5,4772 5,2915 4,8990 5,2915 5,2915 4,4721 5,2915 5,2915 5,8310 4,8990 4,8990 4,6904 4,4721 4,6904 5,0990 5,2915 4,2426 5,0990 5,2915 4,4721 0 5,6569 4,8990 6 4,6904 5,8310 5,8310 6 5,0990 5,0990 5,8310 4,8990 6,1644 4,8990 4,8990 4,8990 4,0000 4,6904 5,0990 5,2915 4,6904 6,4807 6,3246 5,4772 5,8310 6 5,2915 5,8310 6,3246 4,8990 5,4772 4,8990 5,8310 5,4772 4 5,4772 5,8310 6 4,2426 4,4721 5,0990 5,4772 5,7446 6,2450 5,3852 6,3246 6,4807 5,6569 5,6569 6,3246 5,4772 6,3246 5,4772 5,0990 6,1644 5,5678 6,7082 6,0828 6 6,1644 6,1644 5,2915 5,4772 6,1644 5,2915 6,4807 6,3246 5,2915 5,0990 5,7446 6,3246 6,4807 6,1644 6,1644 6,3246 6,0828 6,2450 6,0828 pp. 40—43 6,4807 6 5,6569 5,4772 5,6569 5,8310 4,6904 5,2915 5,6569 5,8310 5,2915 5,0990 5,0990 4,8990 5,2915 5,8310 5,8310 5,8310 5,6569 5,6569 3,7417 5,6569 0 3,4641 6 5,2915 6 Immune5,8310 6,3246 Disorders5,6569 5,6569 5,8310 and5,2915 Inflammatory6,1644 6 6 6,1644Diseases5,0990 5,0990 4,2426 4,2426 5,0990 6,4807 6,3246 5,4772 6,3246 6,4807 5,4772 6 5,6569 5,8310 5,8310 5,8310 6,3246 6,1644 5,2915 6,4807 4,8990 5,4772 4,6904 5,0990 5,0990 4 5,9161 6,5574 5,9161 7,0711 7,0711 6 6 6 3,7417 5,4772 4 4,6904 4,8990 4,1231 6,5574 6,4031 6 5,8310 5,8310 5,0990 5,2915 5,8310 4,8990 5,2915 4,2426 5,4772 5,2915 5,3852 6 6,1644 5,8310 5,4772 5,6569 5,5678 6,4031 6,2450 6,1644 5,4772 5,2915 4,6904 5,0990 5,2915 3,4641 4,8990 5,2915 5,2915 4,8990 4,6904 4,2426 3,7417 4,4721 5,2915 5,0990 5,2915 4,8990 4,8990 2,0000 4,8990 3,4641 0 5,8310 4,8990 5,6569 5,4772 6 5,2915 5,2915 5,4772 4,2426 5,6569 5,4772 5,4772 5,6569 4,2426 4,2426 2,8284 4,2426 4,4721 6,1644 6 4,8990 6 6 4,8990 5,2915 5,0990 5,0990 5,2915 5,4772 6,1644 5,2915 4,4721 6 5,6569 5,0990 3,7417 4,2426 4,4721 4,6904 5,1962 5,9161 5 6,4807 6,4807 5,2915 5,6569 5,4772 4,6904 5,4772 4,8990 5,0990 4,8990 4,7958 6,4031 5,9161 5,2915 5,2915 5,4772 4,6904 4,6904 5,2915 4,4721 5,6569 4,8990 5,0990 4,8990 5 5,4772 5,8310 5,4772 5,4772 5,6569 5,5678 5,9161 5,9161 pp. 44—49 4,2426 3,1623 4,6904 4,6904 5,8310 6 4,8990 4,2426 4,4721 4,8990 4,8990 4,6904 4,6904 5,2915 5,0990 6,1644 6,1644 6 6 6,3246 5,4772 6 6 5,8310 0 4 4,4721 Post-Genomic5,0990 4,8990 4,4721 4,4721 Technologies4,2426 5,2915 4,2426 5,8310 5,8310 5,6569 5,0990 5,0990 5,4772 6 5,6569 4,2426 3,7417 4,2426 5,4772 5,2915 4,4721 4,6904 5,0990 5,0990 4,8990 4,8990 4,6904 5,0990 5,2915 5,4772 7,0711 5,6569 5,8310 6 6,1644 6,1644 4,5826 4,5826 4,5826 5,8310 5,6569 4,4721 5,0990 5,0990 6,3246 5,6569 6,1644 6 6,4807 6,0828 5,7446 4,3589 5,6569 5,6569 5,6569 4,8990 4,6904 5,0990 4,6904 5,2915 5,2915 6 6,1644 5 5,4772 5,6569 5,0990 5,2915 5,0990 5,1962 5 5 5,0990 4 3,7417 4,8990 5,2915 5,4772 4,2426 3,7417 4 4,4721 3,4641 3,1623 3,4641 4,2426 4,8990 5,2915 5,2915 4,8990 5,0990 5,4772 4,4721 4,6904 5,2915 4,8990 4 0 3,7417 4 4 2,8284 2,4495 4 4,2426 4,4721 4,8990 4,8990 4,6904 4 4 4,4721 5,0990 4,6904 5,0990 4,8990 3,7417 4,4721 4,6904 3,1623 4,4721 4,8990 3,7417 3,4641 3,1623 4,4721 4,8990 4,2426 5,2915 6,3246 4,8990 4,6904 5,2915 5,2915 5,2915 4,5826 5,1962 4,5826 5,0990 5,6569 4 3,7417 4,6904 6 5,2915 5,0990 5,6569 6 5,1962 5,7446 5 4,6904 4,6904 4,6904 3,1623 3,4641 4,6904 3,1623 4,8990 4,6904 5,4772 5,2915 3,8730 4,8990 5,0990 4,4721 4,6904 4,8990 4,5826 5 5 pp. 50—53 4 4,4721 4,4721 5,2915 5,6569 5,8310 4,6904 4,6904 5,0990 4,4721 4,6904 4,4721 4,2426 5,0990 5,2915 6 5,6569 5,8310 5,8310 6,1644 5,2915 5,8310 6 5,6569 4,4721 3,7417 0 Diagnostics3,1623 3,7417 3,7417 and4 Therapeutics4,2426 5,0990 4,4721 5,6569 5,6569 5,0990 4,8990 4,8990 5,2915 5,8310 5,4772 5,0990 4,8990 4,6904 3,7417 3,4641 3,7417 5,2915 5,2915 4,2426 4 4,4721 5,0990 5,2915 5,2915 6 6,9282 5,8310 5,6569 5,8310 6 6 4,5826 5,5678 5 4,8990 4,6904 4,4721 4,6904 5,2915 6,3246 6,1644 6 6 6 5,9161 5,7446 5,3852 4,4721 4,4721 4,4721 4,6904 4,4721 4,6904 4,4721 5,8310 5,0990 5,8310 6 4,3589 4,2426 4 4,8990 5,6569 5,4772 4,5826 5,3852 5 3,7417 5,0990 4,2426 5,4772 5,8310 6 4,8990 4,4721 4,8990 3,4641 4 3,4641 4,2426 5,2915 5,0990 6,1644 5,8310 5,6569 6 6 5,0990 5,8310 5,8310 5,4772 5,0990 4 3,1623 0 3,7417 3,4641 4 4,2426 4,8990 4,2426 5,4772 5,4772 5,2915 4,8990 4,6904 5,4772 5,8310 5,4772 5,2915 5,0990 4,4721 4 4,4721 4 5,0990 5,0990 4,2426 3,4641 4,4721 4,8990 5,0990 5,2915 6,1644 6,9282 6 5,2915 6,1644 6,1644 5,8310 4,7958 5,3852 5,1962 4,8990 5,2915 4,6904 4,4721 5,0990 6,6332 6,3246 6 6,3246 6,1644 5,9161 5,9161 5,1962 4,8990 4,8990 4,8990 4,8990 5,0990 4,6904 4,6904 6 5,6569 6,1644 6,1644 4,5826 5,0990 4,6904 5,4772 5,8310 6 5,1962 5,5678 5,1962 pp. 54—63 4,8990 4,8990 4 5,6569 6 6,1644 5,0990 5,0990 5,2915 4,2426 4,2426 4,2426 4,8990 5,2915 6 6,3246 6,3246 6 6,1644 6,4807 5,6569 6 6,3246 6 4,8990 4 3,7417 Principal3,7417 0 Investigators4 4 5,0990 4,8990 4,6904 6 6 5,8310 5,2915 5,2915 5,6569 6 5,8310 5,6569 5,4772 4,8990 4,6904 4,4721 4,6904 5,6569 5,8310 4 3,1623 4,2426 5,0990 5,8310 5,4772 6,3246 7,0711 6 5,8310 6 6,3246 6,1644 5,3852 5,5678 5,3852 5,2915 5,4772 5,2915 3,1623 5,2915 6,4807 6,1644 6,1644 6,1644 6,4807 6,0828 6,2450 6,0828 5,0990 4,8990 4,8990 4,6904 4,4721 4,8990 4,6904 5,8310 5,4772 6 6,1644 5 4,6904 4,8990 5,0990 5,8310 5,6569 5,1962 5,5678 5,5678 5,0990 4,4721 3,1623 5,0990 5,6569 5,6569 4,6904 4,2426 4,2426 4,4721 2,8284 3,1623 4 4,6904 4,6904 5,4772 5,2915 5,2915 5,4772 5,8310 4,8990 5,0990 5,6569 5,2915 4,4721 2,8284 3,7417 3,4641 4 0 2,8284 4 4,2426 4 5,2915 5,2915 4,6904 4,2426 4,4721 4,8990 5,4772 4,8990 5,0990 4,8990 4,2426 4,4721 4,6904 3,1623 4,8990 4,8990 4 3,4641 3,4641 4 4,8990 4,4721 5,6569 6,6332 5,2915 4,8990 5,4772 5,6569 5,6569 4,5826 5,1962 5 5,2915 5,6569 4 3,7417 4,2426 6,3246 5,6569 5,2915 6 6 5,5678 5,7446 5 5,0990 5,0990 5,0990 4 4,2426 5,0990 3,7417 5,2915 5,0990 5,8310 5,6569 3,8730 5,2915 5,0990 4,8990 5,0990 5,2915 4,5826 5,3852 5 5,4772 4,4721 3,7417 5,2915 5,6569 5,8310 4,6904 4,2426 4,4721 4,4721 3,4641 3,1623 3,4641 4,4721 5,2915 5,4772 5,6569 5,2915 5,4772 5,6569 4,8990 5,0990 5,6569 5,2915 4,4721 2,4495 4,0000 4 4 2,8284 0 4,2426 4 4,4721 5,2915 5,2915 5,0990 4,2426 4,4721 4,8990 5,4772 5,0990 5,4772 5,2915 4,2426 4,8990 5,0990 3,7417 4,4721 4,8990 4,2426 3,4641 2,8284 4,4721 5,2915 4,6904 5,2915 6,6332 5,2915 5,0990 5,6569 5,6569 5,6569 5,0000 5,1962 5 5,4772 6 4,4721 3,7417 4,6904 6,3246 5,6569 5,4772 6 6,1644 5,5678 5,9161 5,1962 5,0990 5,0990 5,0990 3,7417 4 5,0990 3,7417 5,2915 5,0990 5,8310 5,6569 4,3589 5,2915 5,4772 4,6904 5,0990 5,2915 5 5 5 4,6904 4,2426 4,4721 4,6904 5,8310 6 4,8990 3,7417 3,7417 4,2426 4,2426 4,2426 4 5,0990 4,2426 6,1644 5,8310 5,6569 6 6 5,0990 5,8310 5,8310 5,4772 4,2426 4 4,2426 4,2426 5,0990 4 4,2426 0 5,0990 3,1623 5,4772 5,4772 5,2915 4,8990 4,8990 5,4772 5,6569 5,4772 4,2426 4 4,2426 4,8990 5,0990 4 4,2426 3,1623 5,0990 4,8990 4,4721 4 3,7417 5,0990 5,4772 6,7823 5,6569 5,4772 6,1644 6,1644 5,6569 4,7958 5 5,1962 5,0990 5,0990 3,7417 4,8990 4,2426 6,4807 5,4772 6 6,1644 6 5,7446 5,7446 4,3589 5,6569 5,4772 5,4772 4,6904 4,8990 4,8990 4,6904 5,0990 5,6569 6,1644 6 4,3589 5,6569 5,4772 5,2915 5,0990 5,2915 5 4,5826 4,3589 6,1644 5,0990 4,6904 4,6904 5,6569 5,8310 3,4641 5,0990 5,4772 5,0990 4,4721 4,4721 4 2 4,6904 5,2915 5,4772 5,4772 5,2915 5,2915 3,7417 4,8990 5,2915 4,2426 5,2915 4,2426 5,0990 4,8990 4,8990 4,2426 4,0000 5,0990 0 4,8990 5,2915 5,2915 5,0990 3,1623 4,4721 3,7417 4,2426 4,6904 6 5,8310 4,6904 5,4772 5,4772 4,4721 5,0990 5,4772 4,6904 4,4721 4,4721 5,2915 5,0990 4,2426 5,4772 6,4807 5,8310 4,6904 5,2915 5,2915 5,0990 5,1962 5,5678 5 6 6,1644 4,8990 4,6904 5,2915 5,6569 5,4772 5,2915 5,2915 4,8990 5 5,9161 5,5678 5,4772 5,4772 5,6569 4,8990 4,8990 5,6569 4,8990 5,8310 5,8310 5,0990 4,8990 5 5,6569 6 5,0990 5,8310 6 5,5678 5,5678 5,5678 4,4721 4 4 4,6904 5,8310 6 4,6904 4,2426 4,2426 4 4,2426 4,2426 4,6904 5,2915 4,6904 6,4807 6 6 6,1644 6,1644 5,2915 6,1644 6,1644 5,6569 4,2426 4,4721 4,4721 4,2426 4,6904 Life4 4,4721 3,1623 4,8990 0 5,8310 5,8310 5,6569 5,2915 5,2915 5,6569 5,8310 5,8310 4,2426 4 4,4721 5,2915 4,8990 4,2426 4,4721 4 5,4772 4,6904 4,6904 3,7417 3,4641 5,4772 5,8310 7,0711 5,8310 5,8310 6,1644 6,4807 6 4,5826 4,3589 5 5,2915 4,8990 4 4,8990 3,7417 6,4807 5,6569 6,3246 6,1644 5,8310 6,0828 5,5678 4,5826 5,8310 5,6569 5,8310 5,0990 4,6904 5,0990 5,0990 5,2915 5,6569 6,1644 6,3246 4,7958 5,4772 5,4772 5,2915 5,2915 5,0990 5 4,3589 4,3589 6,3246 5,6569 5,4772 5,4772 4,4721 4,2426 4,8990 5,0990 5,4772 5,8310 5,2915 5,0990 4,8990 5,2915 5,4772 4,2426 4,4721 4,2426 4 4 5,0990 4,8990 6,0000 5,4772 5,8310 4,8990 5,6569 5,4772 6 5,2915 5,2915 5,4772 5,2915 5,8310 0 0 3,7417 4,8990 5,0990 5,4772 5,8310 5,2915 6,1644 6,1644 5,2915 5,8310 6 5,2915 5,6569 6,1644 5,4772 5,6569 5,4772 6,1644 5,6569 5,2915 4,8990 5,6569 6,1644 5,0990 5,8310 5,4772 5,6569 5,5678 5,9161 5,1962 6,4807 6,4807 5,6569 5,8310 6,4807 6,3246 6,6332 6,1644 6 6,4807 6,0828 6,4031 6,0828 5,8310 5,8310 5,8310 5,6569 5,8310 6 5,4772 6,6332 6,3246 5,8310 5,6569 5,7446 6,1644 6,3246 6,1644 6,1644 6,3246 5,9161 6,0828 5,9161 6,3246 5,6569 5,4772 5,4772 4,4721 4,2426 4,8990 5,0990 5,4772 5,8310 5,2915 5,0990 4,8990 5,2915 5,4772 4,2426 4,4721 4,2426 4 4 5,0990 4,8990 6 5,4772 5,8310 4,8990 5,6569 5,4772 6 5,2915 5,2915 5,4772 5,2915 5,8310 0 0 3,7417 4,8990 5,0990 5,4772 5,8310 5,2915 6,1644 6,1644 5,2915 5,8310 6 5,2915 5,6569 6,1644 5,4772 5,6569 5,4772 6,1644 5,6569 5,2915 4,8990 5,6569 6,1644 5,0990 5,8310 5,4772 5,6569 5,5678 5,9161 5,1962 6,4807 6,4807 5,6569 5,8310 6,4807 6,3246 6,6332 6,1644 6 6,4807 6,0828 6,4031 6,0828 5,8310 5,8310 5,8310 5,6569 5,8310 6 5,4772 6,6332 6,3246 5,8310 5,6569 5,7446 6,1644 6,3246 6,1644 6,1644 6,3246 5,9161 6,0828 5,9161 6,1644 5,4772 5,6569 5,6569 3,7417 4,6904 5,0990 5,4772 5,8310 6 5,4772 5,2915 5,0990 5,0990 5,2915 4,6904 4 4,2426 4,4721 4,8990 5,2915 4,8990 6,1644 5,6569 5,6569 4,6904 5,0990 5,2915 5,8310 Great4,6904 5,0990 Lectures5,2915 5,0990 5,6569 3,7417 3,7417 0 4,8990 5,0990 5,2915 5,8310 5,4772 6,1644 6 5,4772 5,4772 5,6569 4,6904 5,8310 6 5,2915 5,4772 5,2915 5,6569 5,4772 5,2915 3,7417 5,0990 6 5,2915 5,8310 5,2915 5,6569 5,3852 6,0828 5,3852 6 6,1644 5,0990 5,6569 6,0000 6,3246 6,4807 6,1644 6 6,3246 6,0828 6,2450 5,9161 5,6569 5,8310 5,8310 5,2915 5,6569 5,8310 5,2915 6,4807 6 5,8310 5,4772 5,1962 6,1644 6 6 6 6,1644 5,3852 6,2450 5,5678 5,8310 5,0990 4,6904 3,7417 5,2915 5,2915 3,4641 4,6904 4,8990 5,2915 4,4721 4,4721 3,4641 3,1623 3,7417 4,8990 5,4772 5,0990 5,2915 5,0990 3,7417 4,0000 5,0990 4,2426 5,0990 4 4,8990 4,8990 5,2915 4,2426 4,2426 4,8990 3,1623 5,2915 4,8990 4,8990 4,8990 0 3,7417 4 4,2426 3,7417 5,8310 5,6569 4,6904 5,4772 5,6569 4,4721 4,8990 5,4772 4,2426 4,8990 4,8990 5,6569 5,0990 2,8284 5,2915 6,1644 5,8310 4,2426 4,4721 5,0990 5,0990 5 5,7446 4,7958 6,1644 6 4,8990 5,0990 5,8310 5,2915 5,8310 4,8990 4,8990 5,0990 4,7958 5,9161 5,3852 5,4772 5,6569 5,6569 4,8990 5,0990 5,6569 4,6904 6 5,6569 5,0990 4,8990 5 5,8310 6 5,0990 5,8310 6 5,5678 5,5678 5,3852 5,6569 5,0990 4,8990 4,8990 4,6904 4,8990 4,2426 4,6904 5,0990 5,2915 4,6904 4,2426 4 4,4721 4,8990 4,8990 4,8990 5,2915 4,6904 4,8990 3,7417 4,6904 5,0990 4,2426 5,0990 4 4,8990 4,6904 5,2915 Scientific4,4721 4,4721 4,8990 Meetings4,4721 5,2915 5,0990 5,0990 5,0990 3,7417 0 3,7417 4 3,4641 5,8310 5,6569 4,6904 5,2915 5,6569 4,4721 5,0990 5,0990 4,4721 4,8990 4,8990 5,6569 5,0990 4,2426 5,6569 5,8310 5,0990 3,7417 4,2426 4,6904 4,8990 5 5,7446 4,7958 6,1644 6 4,8990 5,0990 5,2915 5,0990 5,0990 4,6904 4,4721 5,2915 4,5826 6,2450 5,7446 4,6904 5,0990 5,0990 4,2426 4,4721 5,0990 4,0000 5,4772 5,0990 4,4721 4,4721 4,1231 5,2915 5,2915 4,6904 5,2915 5,4772 4,7958 5,7446 5,5678 6,3246 5,2915 5,4772 4,8990 5,0990 5,2915 3,7417 5,2915 5,6569 5,6569 5,2915 5,0990 4,6904 3,7417 4,8990 5,0990 4,8990 5,6569 4,6904 5,0990 3,1623 5,0990 4,2426 2,8284 5,4772 4,4721 5,2915 5,4772 5,6569 4,8990 4,8990 5,4772 3,7417 5,6569 5,4772 5,4772 5,2915 4 3,7417 0 3,7417 4 6,3246 6,1644 5,0990 5,8310 5,8310 4,6904 5,4772 5,4772 4,8990 5,0990 5,2915 6,0000 5,4772 4,4721 5,8310 5,8310 4,6904 4,2426 3,7417 4 4,6904 5,3852 6,0828 5,1962 6,3246 6,4807 5,0990 5,4772 5,4772 4,8990 5,0990 4,6904 4,8990 4,8990 4,5826 6,5574 6,0828 4,8990 5,2915 5,4772 4,6904 4,6904 5,2915 4,4721 5,6569 4,8990 4,6904 4,4721 4,5826 5,4772 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5,4772 5,2915 5,2915 5,2915 2,8284 4,2426 4,4721 4,6904 4,2426 5,6569 5,4772 4,6904 5,4772 5,6569 4,4721 4,8990 5,4772 4 4,6904 4,6904 5,2915 4,8990 0 5,2915 6,1644 5,6569 4 4 5,0990 5,0990 5,1962 5,7446 5 6 6 4,8990 5,0990 5,6569 5,4772 5,6569 4,8990 5,0990 5,6569 5 6,4031 5,7446 5,6569 5,8310 5,8310 4,8990 5,0990 5,6569 4,6904 5,8310 5,8310 5,2915 5,0990 5,1962 6 6,1644 5,6569 5,6569 5,8310 5,7446 5,7446 5,7446 6,3246 5,2915 6 5,0990 4,2426 5,0990 5,4772 5,2915 5,4772 5,8310 5,8310 5,6569 5,2915 5,2915 5,0990 4,8990 4,8990 4,8990 4,8990 5,0990 5,6569 5,4772 6,4807 6 5,4772 5,2915 6 6,1644 6,3246 5,6569 5,2915 5,4772 5,4772 5,8310 4,8990 4,8990 3,7417 5,2915 5,6569 5,8310 6,3246 6 6 5,8310 5,6569 6,1644 6,3246 5,2915 4,8990 5,4772 5,4772 5,6569 5,6569 5,6569 5,4772 5,2915 0 5,4772 5,8310 5,4772 6 5,8310 5,8310 6,0828 6,2450 6,0828 6,4807 6,6332 5,2915 6 6 6,6332 6,1644 6,4807 6,3246 6,7823 6,4031 7 5,7446 6,3246 6,4807 6,4807 5,6569 6 6 5,6569 6,1644 6,3246 6,1644 5,8310 5,9161 6,6332 6,7823 6,1644 6,1644 6,3246 6,4031 5,9161 5,5678 7,4833 6,6332 6,6332 6,7823 4,8990 5,4772 6,3246 6,6332 6,9282 7,0711 6,4807 6,4807 6,3246 6,3246 6,7823 5,6569 5,4772 5,4772 5,4772 5,6569 5,8310 5,8310 4,8990 5,6569 7,0711 6,3246 6,9282 Employees6,9282 7,0711 6,6332 6,6332 6,7823 6,4807 7,0711 5,6569 5,6569 5,0990 6,1644 5,8310 5,8310 5,4772 6,1644 7,2111 7,0711 6,3246 6,6332 6,7823 6,3246 6,7823 6,4807 6,4807 6,6332 6,1644 6,7823 6,4807 6,1644 5,4772 0 5,8310 5,6569 5,6569 5,6569 5,2915 6,8557 7,2801 6,7082 7,4833 7,3485 6,7823 6,7823 6,7823 4,4721 6,3246 5,6569 5,4772 6,3246 5,5678 7,1414 7,1414 6,6332 6,4807 6,4807 6 6,1644 6,6332 6 6,1644 5,4772 6,1644 6 6,2450 6,6332 6,7823 6,6332 6,3246 6,4807 6,2450 7,1414 7 6,3246 5,2915 5,6569 6 5,6569 5,8310 5,6569 5,2915 5,4772 5,6569 5,4772 5,2915 5,2915 5,6569 6 5,6569 5,4772 6 5,2915 5,6569 5,2915 6,0000 5,4772 5,0990 5,6569 4,8990 5,8310 6 6 5,2915 5,2915 5,6569 5,8310 5,8310 6,1644 6,1644 6 5,8310 5,0990 4,6904 5,4772 5,6569 6,1644 6 5,2915 6 6 4,8990 5,2915 5,2915 5,2915 5,0990 5,2915 5,6569 5,6569 5,6569 5,8310 5,8310 0 5,4772 5,2915 5,2915 5,6569 5,7446 6,0828 5,9161 6,1644 6,4807 5,0990 5,6569 5,2915 6 5,0990 5,6569 6 6,1644 5,7446 6,7082 6,0828 5,0990 5,6569 5,8310 4,8990 4,8990 5,2915 4,6904 5,0990 5,2915 5,8310 5,6569 5 5,8310 6,1644 5,4772 5,2915 5,4772 5,1962 6,0828 6,2450 6 5,6569 4,8990 4,6904 4,6904 4,8990 4 5,0990 5,2915 5,6569 4,6904 4,4721 4,4721 4,4721 4,6904 5,0990 5,0990 4,8990 4,8990 4,8990 3,1623 4,2426 4,6904 3,7417 5,8310 4,6904 5,6569 Directory5,2915 5,8310 4,8990 5,0990 5,4772 4,6904 5,8310 5,0990 5,0990 5,2915 4,2426 3,7417 4,2426 4,6904 4,2426 6 5,8310 4,8990 5,6569 6 4,8990 5,2915 5,0990 4,6904 5,0990 5,0990 5,8310 5,2915 4 5,4772 5,6569 5,4772 0 3,7417 4,2426 4,2426 5,3852 6,0828 5,1962 6,4807 6,6332 5,4772 5,4772 5,4772 4,6904 5,6569 4,6904 4,4721 5,2915 5 6,5574 6,0828 5,4772 5,4772 5,4772 4,4721 4,6904 5,4772 4,2426 5,6569 5,4772 4,2426 4,2426 5 5,6569 5,6569 5,4772 5,4772 5,6569 5,5678 6,0828 5,9161 6,4807 5,8310 5,2915 4,8990 4,8990 4,8990 4,4721 5,8310 5,8310 6,3246 5,4772 5,4772 5,2915 5,0990 5,2915 5,2915 5,4772 5,6569 5,2915 5,4772 4,4721 4,4721 5,0990 4,2426 6 5,2915 5,8310 6,1644 6 5,4772 5,6569 6,1644 5,2915 6,1644 5,8310 5,8310 5,8310 4,4721 4,2426 3,7417 4,8990 4,2426 6,3246 6,1644 5,6569 6,3246 6,1644 5,4772 6 6 5,0990 5,6569 5,6569 6,3246 6 4 6 5,6569 5,2915 3,7417 0 4 4,8990 5,7446 6,4031 5,5678 6,9282 6,6332 6 6 6,1644 4,2426 6 5,0990 4,2426 5,4772 5,1962 6,8557 6,7082 5,8310 6,1644 6,1644 5,2915 5,0990 6,1644 5,0990 6,3246 5,2915 4,4721 4,6904 5,3852 6 6,1644 5,4772 6,1644 6 5,5678 6,4031 6,2450 6,7823 5,8310 6 5,6569 5,2915 5,2915 5,0990 5,8310 6,1644 6,3246 5,8310 5,6569 5,4772 5,0990 5,6569 5,0990 5,0990 5,6569 4,8990 5,2915 4,6904 5,0990 5,0990 4,4721 6,1644 5,2915 6 Publications6,1644 6,3246 5,6569 5,6569 6,1644 5,2915 6,4807 5,4772 5,4772 5,2915 5,0990 4,6904 4 5,2915 4,2426 6,6332 6,4807 5,6569 6 6,1644 5,2915 6 6 5,4772 5,6569 5,4772 6,1644 6 5,0990 5,8310 5,6569 5,2915 4,2426 4 0 4,8990 6,0828 6,4031 5,7446 6,6332 6,7823 5,8310 6 6,1644 5,0990 6,1644 5,2915 5,0990 6 5,3852 6,8557 6,5574 5,2915 5,6569 5,6569 5,2915 5,4772 5,6569 5,0990 6,3246 5,4772 4,6904 4,4721 5,1962 6 6,1644 5,4772 5,8310 6 5,3852 6,5574 6,4031 6,4807 6 5,4772 5,4772 4,8990 5,2915 4,6904 5,4772 5,8310 6 5,2915 5,2915 5,2915 4,8990 5,4772 5,4772 5,4772 5,6569 5,2915 5,2915 4,2426 5,4772 4 4,6904 6,1644 5,2915 6 5,8310 6,1644 5,6569 5,6569 5,6569 5,0990 6 5,6569 5,6569 5,6569 5,0990 4,8990 4,6904 3,4641 4,8990 6,1644 6 5,0990 6 6,1644 5,2915 5,8310 5,4772 5,6569 5,6569 5,4772 6,1644 5,8310 5,0990 5,8310 5,2915 5,6569 4,2426 4,8990 4,8990 0 5,9161 6,5574 5,9161 6,9282 6,9282 6 5,8310 6 4,6904 4,8990 4 3,7417 4 3,3166 6,2450 6,4031 5,8310 5,8310 5,8310 4,8990 5,2915 6 5,0990 5,0990 5,2915 4,6904 4,2426 5 6 6,1644 5,2915 5,4772 5,6569 5,1962 6,2450 5,9161 4,5826 4,7958 4,5826 5 5,3852 5,5678 4,1231 4,7958 5,1962 5,1962 4,7958 4,5826 4,3589 5 5 6,0828 5,5678 5,5678 5,7446 5,7446 4,7958 5,7446 5,9161 5,1962 4,5826 4,5826 4,5826 Facts4,7958 5,3852and 4,5826Figures5 4,7958 5,1962 4,5826 5,5678 5,5678 5,3852 5 5 5,3852 5,7446 5,5678 4,3589 4,3589 3,6056 5,3852 5 4,1231 5 5,1962 4,7958 5 5,1962 5,5678 4,5826 5,1962 6,0828 6,8557 5,7446 5,3852 5,7446 6,0828 5,9161 0 4 2,4495 5,7446 5,3852 4,3589 5,1962 5,3852 6,0828 5,9161 5,9161 5,7446 5,3852 5,6569 4,2426 4,4721 5,3852 5,7446 5,9161 5,1962 4,7958 5,7446 5 6,0828 5,5678 5,9161 6,0828 4,6904 5,5678 5,5678 5,3852 5,9161 5,7446 4,8990 5,0990 4,6904 5,1962 4,5826 4,7958 5,1962 6,0828 6,2450 5 5 5 4,5826 5 4,7958 5 5,7446 5,5678 6,7082 6,5574 6,0828 6,4031 6,4031 5,5678 6,2450 6,5574 5,9161 4,5826 5,1962 5,5678 5,3852 5,5678 5,1962 5,1962 5 5,5678 4,3589 5,9161 5,9161 6,0828 5,7446 5,7446 6,0828 6,4031 6,2450 4,7958 4,7958 4,3589 6,0828 5,7446 4,7958 4,5826 5,3852 5,7446 5,1962 5,1962 5,1962 5 5,7446 6,2450 7,2801 6,0828 6,0828 6,4031 6,4031 6,5574 4 0 3,4641 5 4,5826 3,8730 5,3852 5,1962 6,7082 6,0828 6,5574 6,4031 6,4031 6,3246 4,6904 4,6904 5,3852 5,9161 6,0828 5,7446 5,3852 5,1962 5,5678 6,0828 6,0828 6,5574 6,7082 5,6569 5,9161 6,2450 5,9161 5,3852 5,1962 5,4772 4,2426 5,2915 5 4,5826 4,5826 4,7958 5,3852 5,5678 3,8730 4,7958 5,1962 5,1962 4,7958 4,5826 4,1231 4,7958 5,1962 6,0828 5,9161 5,3852 5,7446 5,7446 4,5826 5,3852 5,9161 5 4,5826 4,5826 5 Testimonials5,1962 5,3852 5 5 5,1962 5 5,0000 5,1962 5,1962 5,3852 4,7958 4,7958 5,1962 5,5678 5,5678 4,7958 4,7958 3,6056 5,5678 5,1962 4,5826 5 5,5678 4,5826 5 5 5,7446 4,5826 5 6,0828 6,7082 5,9161 5,1962 5,5678 5,7446 5,9161 2,4495 3,4641 0 5,7446 5,3852 4,7958 5,1962 5,7446 5,9161 5,7446 5,9161 5,5678 5,5678 5,6569 4,4721 4,6904 5,1962 5,3852 5,5678 5,1962 4,7958 5,3852 5,0000 6,0828 5,5678 5,7446 5,9161 5,0990 5,3852 5,7446 5,3852 5,5678 5,3852 4,8990 4,8990 4,8990 5,2915 5,2915 5,8310 6,1644 6,9282 7,0711 6 5,6569 5,4772 4,6904 5,6569 5,6569 5,6569 5,8310 5,8310 6,9282 6,4807 6,4807 6,6332 6,9282 6,1644 6,3246 7,0711 6,4807 5,8310 5,0990 4,8990 4,8990 5,2915 5,2915 5,4772 5,0990 6 5,2915 6,4807 6,4807 6 6,1644 6,1644 6,3246 6,6332 6,6332 6 5,8310 5,6569 5,0990 5,0990 4,6904 5,2915 5,4772 5,0990 4,8990 5,0990 5,0990 5,0990 6 6,4807 7,4833 6,1644 6,4807 6,9282 6,6332 6,9282 5,7446 5 5,7446 0 3,4641 3,7417 5,2915 5,0990 7,2111 6 6,7823 6,9282 6,6332 6,7082 6,0828 5,7446 4,8990 5,2915 5,4772 5,2915 5,2915 4,4721 5,6569 6 6,6332 6,9282 6,7823 5,5678 5,6569 5,6569 6,1644 5,4772 5,6569 5,7446 5,1962 5,9161 5,2915 5,0990 5,6569 5,8310 6,6332 6,7823 5,6569 5,6569 5,6569 4,8990 5,8310 5,8310 5,6569 6 5,8310 7,0711 6,6332 6,6332 6,7823 6,9282 6,1644 6,4807 7,0711 6,4807 5,6569 5,6569 4,6904 Acknowledgements5,2915 5,4772 5,6569 6 5,0990 6,1644 4,8990 6,4807 6,4807 6,1644 6 6 6,4807 6,4807 6,4807 5,6569 5,4772 5,6569 4,6904 4,4721 4,8990 5,2915 5,4772 5,6569 5,4772 5,8310 5,4772 5,0990 6 6,6332 7,3485 6,4807 6,6332 6,6332 6,7823 6,9282 5,3852 4,5826 5,3852 3,4641 0 4 5,6569 5,4772 6,7823 6,3246 6,7823 6,4807 6,3246 6,5574 5,7446 5,7446 4,6904 5,0990 5,0990 6 5,6569 4,6904 6 6,3246 6,4807 6,7823 6,9282 5,7446 4,8990 5,0990 6 5,8310 5,6569 5,5678 4,7958 5,5678 5,0990 4 4,8990 4,8990 5,8310 6 4,6904 4,2426 4,2426 4,2426 4,6904 4,4721 4,2426 4,6904 4,4721 5,8310 5,2915 5,6569 5,4772 5,8310 4,8990 5,6569 6 5,2915 4,4721 4 4,4721 4,6904 5,2915 4 4,4721 3,7417 4,8990 4 5,6569 5,6569 5,0990 4,8990 4,8990 5,0990 5,6569 5,4772 4,8990 4,6904 4,4721 4,8990 4,8990 2,8284 3,7417 4,2426 4,6904 4,4721 4,6904 4,2426 4 4,8990 5,2915 6,7823 5,0990 5,4772 6 5,8310 6 4,3589 3,8730 4,7958 3,7417 4 0 4,6904 4 6,3246 5,0990 5,8310 6 5,8310 5,7446 5,3852 4,5826 4,6904 5,2915 5,4772 4,6904 4,6904 4,4721 4,4721 5,0990 5,4772 6 5,8310 4,3589 5,4772 5,4772 5,2915 4,6904 4,8990 5 4,3589 5 5,6569 4,8990 4 5,6569 6 6,1644 5,0990 4,6904 4,8990 4,6904 3,7417 3,7417 4,4721 4,8990 5,6569 6 6 5,6569 5,8310 6,1644 5,2915 5,6569 6 5,6569 5,0990 3,7417 4,6904 How4,4721 3,1623to Reach3,7417 3,7417 CeMM4,8990 4,6904 4,8990 5,8310 5,8310 5,6569 5,0990 5,0990 5,4772 5,8310 5,6569 5,6569 5,4772 4,4721 4,8990 5,0990 4,2426 5,2915 5,4772 4,4721 3,7417 3,7417 4,6904 5,4772 5,0990 6 6,7823 5,6569 5,4772 6 6 5,8310 5,1962 5,3852 5,1962 5,2915 5,6569 4,6904 0 4,6904 6,3246 5,6569 5,6569 6 6 5,5678 6,2450 5,7446 5,2915 5,0990 5,0990 4,2426 4,4721 5,2915 4,2426 5,4772 5,4772 6 5,8310 4,5826 5,2915 5,4772 4,6904 5,4772 5,6569 5,1962 5,3852 5,5678 5,4772 4,6904 4,8990 5,6569 6,1644 6,3246 5,6569 4,8990 4,4721 4,6904 4,6904 4,4721 5,2915 5,4772 5,2915 6,1644 5,6569 6,1644 5,8310 6,1644 5,0990 6,3246 6 5,4772 5,0990 4,6904 5,2915 5,0990 5,2915 4,2426 4,6904 4,2426 5,2915 3,7417 6,4807 6,4807 6 5,8310 5,2915 5,4772 5,8310 5,8310 5,2915 5,0990 5,0990 5,4772 5,4772 4,4721 5,0990 3,7417 5,4772 4,6904 4,6904 3,1623 4,4721 5,6569 6 6,7823 5,2915 5,4772 6,1644 6,1644 6 5,3852 5,1962 5,7446 5,0990 5,4772 4,0000 4,6904 0 6,3246 4,6904 5,8310 6,1644 6 5,7446 6,4031 5,1962 5,4772 5,0990 5,2915 4,2426 4,2426 4,4721 4,0000 4,2426 5,4772 6,1644 6 4,3589 5,2915 5,2915 5,2915 4,2426 4,4721 5 5,3852 5,3852 6,9282 6,3246 6 5,6569 5,6569 5,8310 5,0990 6,3246 6,6332 6,7823 6,1644 6,1644 5,8310 5,4772 6 6,1644 6,1644 6,3246 6 6,1644 4,8990 5,4772 3,7417 4,6904 6,3246 6 6,3246 Imprint6,6332 6,4807 6,3246 6,3246 6,4807 5,6569 6,4807 6,3246 6,3246 6,3246 5,2915 5,0990 4,8990 4,4721 5,2915 6,7823 6,6332 6,1644 6,7823 6,6332 6,1644 6,6332 6,3246 6,1644 6,4807 6,3246 6,7823 6,4807 5,4772 6,6332 4,4721 6 4,6904 4,2426 5,0990 4,6904 6,0828 6,7082 5,9161 7,2111 6,7823 6,3246 6,3246 6,3246 0 5,6569 4,6904 3,1623 4,8990 4,5826 6,7082 7,1414 6,4807 6,3246 6,3246 5,6569 5,4772 6,4807 5,6569 5,8310 4,6904 4,6904 4,8990 5,9161 6,1644 6,3246 6 6,1644 6 5,7446 6,7082 6,5574 6,4807 5,2915 5,8310 5,6569 6,1644 6,3246 5,4772 5,4772 5,2915 5,8310 5,6569 5,4772 5,4772 5,2915 5,6569 6,1644 6 6,3246 5,8310 6,1644 5,0990 6,3246 5,4772 5,4772 5,6569 5,2915 6,1644 6,3246 6,1644 5,6569 5,6569 5,4772 5,4772 5,6569 6,6332 6,6332 6,4807 5,8310 5,0990 5,0990 4,2426 5,8310 6,1644 6 5,6569 6,3246 6,3246 5,4772 5,4772 5,2915 5,4772 5,6569 5,6569 5,4772 5,2915 5,6569 6,1644 6,3246 5,0990 5,6569 6 6,1644 4,8990 5,9161 6,0828 5,7446 6 6,3246 5,0990 5,6569 4,6904 5,6569 0 4,8990 4,8990 4,8990 4,5826 6,4031 6,0828 5,6569 5,8310 6 5,0990 5,0990 5,4772 4,8990 2,8284 5,6569 5,6569 5,4772 5,1962 6 6,3246 5,6569 4,4721 4,6904 5,3852 6,0828 6,0828 6,6332 6 5,4772 5,6569 5,6569 5,6569 4,8990 5,4772 5,8310 6,1644 5,2915 5,2915 5,4772 5,0990 5,6569 5,6569 5,6569 6 5,4772 5,6569 4,4721 5,4772 4 4,8990 6,1644 5,0990 6 6 6,1644 5,2915 5,4772 6 5,2915 6,3246 6,1644 6,1644 6,1644 4,8990 4,6904 4,6904 3,7417 4,4721 6,4807 6,3246 5,6569 6,3246 6,4807 5,4772 6,1644 6 5,6569 5,6569 5,6569 6,3246 6,3246 4,8990 6,4807 5,6569 5,6569 4,6904 5,0990 5,2915 4 5,9161 6,5574 5,9161 6,7823 6,7823 5,8310 5,6569 5,8310 4,6904 4,8990 0 4,2426 4,6904 3 6,7082 6,5574 5,8310 6 6 5,0990 5,2915 6 4,8990 5,2915 5,2915 5,0990 4,8990 5 6,1644 6,3246 5,0990 5,4772 5,6569 5,3852 6,5574 6,4031 6,6332 6 5,6569 5,2915 5,0990 5,2915 4,6904 6 6,3246 6,4807 5,8310 5,8310 5,4772 5,0990 5,6569 5,6569 5,6569 6 5,4772 5,6569 4,6904 5,0990 4,6904 5,0990 6 5,6569 6 6,3246 6,1644 6 6 6,1644 5,2915 6,1644 6 6 6 4,8990 4,4721 4,8990 3,1623 4,6904 6,4807 6,3246 5,8310 6,4807 6,3246 5,8310 6,3246 6,1644 5,8310 6,1644 6 6,4807 6,1644 5,0990 6,3246 5,4772 6 4,4721 4,2426 5,0990 3,7417 5,7446 6,4031 5,5678 6,9282 6,4807 6 6 6,1644 3,1623 4,8990 4,2426 0 4 3,6056 6,2450 6,8557 6 6,1644 6,1644 5,4772 5,2915 6,3246 5,4772 5,4772 5,4772 3,7417 4 5,3852 6 6,1644 5,4772 5,8310 5,6569 5,1962 6,4031 6,2450 6,4807 6,1644 5,8310 5,4772 5,6569 5,8310 4,4721 6,1644 6,4807 6,4807 6 6 5,2915 4,6904 5,4772 6 5,8310 6,4807 6 5,6569 4,4721 6,1644 4,8990 4,8990 6,4807 6 6 6,1644 6,4807 6 6,1644 6 4,8990 5,8310 6,4807 6,4807 6,3246 5,0990 5,2915 4,8990 3,7417 5,4772 6,3246 6,1644 5,8310 6,4807 6,1644 5,6569 6,1644 5,6569 6,1644 6,3246 6,3246 6,6332 5,8310 5,6569 6,7823 6,3246 6,1644 5,2915 5,4772 6 4 5,3852 6,4031 5,5678 6,6332 6,3246 5,8310 6 6 4,8990 4,8990 4,6904 4 0 4,1231 5,5678 6,2450 6,1644 6,3246 6,4807 5,8310 5,4772 6,4807 5,8310 5,6569 5,8310 5,0990 5,2915 5,3852 6,1644 6,1644 4,8990 6 5,8310 5,1962 6,0828 5,9161 6,5574 5,9161 5,5678 5,5678 5,5678 5,7446 4,7958 5,3852 5,9161 6,0828 5,3852 5,3852 5,3852 4,7958 5,5678 5,7446 5,7446 6,0828 5,5678 5,7446 4,3589 5,5678 4,1231 4,7958 6,0828 5,1962 5,9161 5,9161 6,0828 5,5678 5,5678 5,7446 5 6,0828 6,0828 6,0828 6,0828 4,7958 4,5826 4,5826 3 4,5826 6,2450 6,0828 5,3852 6,0828 6,2450 5,3852 6,0828 5,7446 5,7446 5,7446 5,5678 6,2450 6,0828 5 6,4031 5,5678 5,7446 5 5,1962 5,3852 3,3166 5,6569 6,3246 5,6569 6,7082 6,5574 5,7446 5,5678 5,7446 4,5826 4,5826 3 3,6056 4,1231 0 6,1644 6,3246 5,7446 5,7446 5,7446 5 5,1962 5,9161 5 5 5,3852 5 4,7958 4,2426 5,9161 6,0828 5,1962 5,3852 5,5678 4,6904 6,1644 6 5,7446 5,7446 5,5678 6,2450 6,5574 6,7082 5,5678 5,9161 6,2450 6,2450 5,7446 5,7446 5,1962 5,7446 6,2450 6,8557 6,7082 6,5574 6,8557 6,5574 6,0828 6,7082 6,5574 6,4031 5,7446 5,7446 5,7446 5,9161 6,2450 5,7446 5,9161 5,7446 5,9161 5,5678 6,4031 6,4031 6,2450 5,9161 6,2450 6,5574 6,0828 6,7082 5,3852 5,3852 4,5826 6,0828 5,7446 5 5,5678 5,9161 6,2450 6,0828 5,9161 6,2450 5,7446 6,4031 7 7,1414 6,7082 6,5574 6,8557 6,8557 6,2450 4,2426 4,6904 4,4721 6,0828 5,7446 5,3852 6,2450 6,4031 6,7082 6,4031 6,7082 6,2450 5,5678 6,1644 0 4,8990 5,5678 6,0828 6,2450 5,9161 5,5678 6,2450 5,9161 6,0828 5,5678 6,7082 6,8557 5,4772 6,2450 6,2450 5,9161 5,5678 5,3852 5,4772 5,2915 5,4772 4,5826 4,3589 5,3852 5,1962 6,4031 6,5574 5,3852 4,5826 4,7958 5 5,1962 5 4,5826 5,3852 4,7958 6,4031 6,2450 5,9161 6,4031 6,0828 5,5678 6,0828 6,4031 5,9161 4,3589 5 5,3852 5,1962 6,0828 5 5,1962 4,3589 5,5678 4,5826 6,0828 6,0828 5,9161 5,3852 5,7446 6,0828 6,4031 6,2450 4,5826 4,1231 4,3589 5,3852 5,3852 4,5826 4,5826 4,5826 5,7446 5,3852 5,1962 4,7958 4,3589 5,7446 5,7446 7,1414 6,0828 6,0828 6,7082 6,5574 6,4031 4,4721 4,6904 4,6904 5,7446 5,7446 4,5826 5,7446 5,1962 7,1414 6,0828 6,5574 6,8557 6,2450 6,3246 4,8990 0 5,7446 5,7446 5,9161 5,3852 5,3852 5,1962 5,1962 5,5678 6,0828 6,7082 6,5574 4,8990 6,0828 6,0828 5,7446 5,5678 5,7446 5,4772 4,8990 4,6904 5,6569 5,0990 5,4772 6 5,6569 5,8310 5,2915 5,2915 5,6569 4,8990 5,2915 5,0990 4,8990 5,2915 6 5,6569 5,4772 6 5,2915 5,6569 4,8990 6 6 5,2915 5,6569 4,6904 4,4721 4,8990 5,0990 5,0990 5,0990 5,6569 5,4772 5,8310 5,8310 5,8310 5,6569 5,4772 4,6904 4,8990 5,4772 5,2915 6,3246 6,1644 5,0990 4,4721 4,4721 4,2426 5,0990 5,4772 4,6904 4,4721 5,0990 5,8310 5,6569 5,6569 6,3246 6,6332 5,0990 5,4772 5,8310 5,2915 5,8310 5,3852 5,3852 5,1962 4,8990 4,6904 4,6904 5,2915 5,4772 6,4807 5,6569 5,8310 6 6,1644 5,7446 5,5678 5,7446 0 3,1623 3,4641 4,4721 4,4721 3,4641 4,2426 5,4772 5,2915 5,6569 5,4772 4,3589 4 4,4721 5,0990 5,0990 5,2915 4,7958 5,5678 6,0828 5,6569 5,0990 5,2915 6,1644 6 6,1644 5,4772 5,0990 5,4772 4,8990 5,0990 5,0990 5,0990 5,2915 6,1644 6 5,8310 6,1644 5,6569 6 4,8990 6,1644 5,8310 5,2915 5,6569 4,6904 4,4721 4,8990 4,8990 5,0990 5,0990 5,4772 5,4772 5,6569 5,8310 5,8310 5,8310 5,6569 5,0990 5,2915 5,6569 5,4772 6 6 4,8990 4 3,7417 4,6904 5,6569 5,0990 4,8990 4,4721 4,8990 5,6569 5,6569 5,8310 6,4807 6,4807 5,6569 5,4772 6,1644 5,6569 5,8310 5,7446 5,9161 5,3852 5,2915 5,0990 5,2915 5,0990 5,0990 6,3246 5,8310 6 6,1644 6,3246 5,7446 6,0828 5,7446 3,1623 0 2 4 4 3,1623 4 5,0990 5,0990 5,6569 5,4772 4,3589 3,1623 3,4641 5,0990 4,8990 5,0990 4,7958 5,7446 5,9161 5,6569 5,2915 5,2915 6,1644 6 6,1644 5,6569 5,0990 5,4772 5,0990 5,0990 5,0990 5,0990 5,4772 6,1644 6 6 6,1644 5,8310 6,1644 5,0990 6,1644 5,8310 5,4772 5,6569 4,6904 4,4721 4,8990 4,8990 5,0990 5,0990 5,4772 5,6569 5,8310 5,8310 5,8310 5,8310 5,6569 5,0990 5,4772 5,8310 5,4772 6 6 5,0990 3,7417 4,2426 4,8990 5,8310 5,2915 4,8990 4,6904 4,8990 5,6569 5,8310 5,8310 6,4807 6,4807 5,8310 5,4772 6,1644 5,6569 5,8310 5,9161 6,0828 5,5678 5,4772 5,0990 5,4772 5,0990 5,2915 6,3246 6 6 6,1644 6,4807 5,7446 6,2450 5,9161 3,4641 2 0 4 4,2426 3,4641 4 5,2915 5,0990 5,6569 5,4772 4,3589 3,1623 3,7417 5,0990 5,0990 5,2915 4,7958 5,9161 5,9161 5,6569 4,6904 4,2426 5,4772 5,0990 5,4772 4,8990 4,4721 4,6904 5,0990 4 4 4,2426 4,6904 5,4772 5,2915 5,2915 5,4772 5,0990 5,4772 4,2426 5,2915 5,0990 4,6904 4,8990 3,1623 4,6904 4,8990 4,6904 4 3,7417 4,6904 4,8990 5,0990 5,6569 5,6569 5,2915 4,8990 4,2426 4,6904 5,0990 4,8990 5,4772 5,2915 4,2426 4,8990 5,0990 4 5,0990 4,4721 4,4721 4,2426 3,4641 4,8990 5,2915 4,8990 5,6569 6 4,8990 4,4721 5,2915 5,2915 4,8990 5,1962 5,7446 5,1962 5,2915 6 4,6904 4,2426 4,2426 5,6569 5,0990 5,0990 5,4772 5,8310 5 5,9161 5,3852 4,4721 4 4 0 2 4,2426 2,4495 4,2426 4 5,0990 4,6904 3,3166 4,4721 4,6904 4,2426 4,4721 4,6904 4,3589 5,3852 5,1962 5,4772 4,2426 4,0000 5,2915 5,0990 5,2915 4,4721 4,6904 4,8990 5,0990 4,2426 4,2426 4,4721 4,6904 5,6569 5,4772 5,2915 5,6569 5,0990 5,4772 4,2426 5,4772 5,2915 4,6904 4,6904 3,4641 4,4721 5,0990 4,4721 4,2426 4 4,8990 4,8990 4,6904 5,8310 5,8310 5,6569 5,0990 4,4721 4,6904 5,0990 5,0990 5,2915 5,0990 4,2426 5,0990 4,6904 4 5,0990 4,4721 4,6904 4,2426 3,7417 5,0990 5,2915 5,0990 6 6,1644 4,8990 4,6904 5,0990 5,4772 5,2915 4,7958 5,3852 4,7958 5,2915 5,6569 4,6904 4,4721 4,2426 5,4772 5,0990 5,2915 5,2915 5,4772 5,1962 5,5678 5,3852 4,4721 4 4,2426 2 0 4,2426 2,8284 4,2426 4 4,8990 5,0990 3,6056 4 4,4721 4 4,4721 4,2426 4,1231 5 5,1962 5,0990 4,4721 5,4772 5,6569 6 6,1644 5,4772 4,8990 4,8990 3,7417 5,2915 5,0990 5,0990 5,4772 5,6569 6 5,8310 6,1644 5,6569 6 4,8990 6,1644 5,8310 5,2915 5,0990 4,6904 4,6904 4,6904 4,8990 5,0990 5,0990 4,8990 5,6569 5,0990 6 6 5,8310 5,6569 5,0990 5,2915 5,8310 5,6569 5,8310 5,6569 5,0990 4,6904 4,6904 4,6904 5,0990 4,4721 4,6904 4,2426 5,0990 5,0990 5,0990 5,6569 6 6,6332 5,2915 5,4772 6,1644 5,6569 6 5,7446 5,1962 5,3852 4,4721 4,6904 4,4721 5,2915 4,4721 6,4807 5,4772 6 6,3246 6,4807 5,9161 6,2450 5,1962 3,4641 3,1623 3,4641 4,2426 4,2426 0 4 4,6904 5,0990 6 5,8310 4,5826 4 4,4721 5,2915 4 4,2426 5 5,1962 5,7446 5,4772 4,4721 4,2426 5,2915 5,0990 5,2915 4,6904 4,2426 4,2426 4,8990 4,0000 3,4641 4 4,6904 5,2915 5,0990 5,0990 5,0990 4,8990 5,2915 4 5,2915 4,8990 4,4721 4,6904 3,1623 4,4721 4,6904 4,6904 3,7417 3,7417 4,6904 4,8990 5,0990 5,4772 5,4772 5,2915 4,6904 4 4,4721 5,0990 4,6904 5,4772 5,2915 4,2426 4,8990 5,0990 3,7417 4,8990 4,4721 4,2426 4 4 4,6904 5,2915 4,6904 5,6569 6 4,6904 4,2426 5,0990 5,0990 5,0990 5 5,5678 5 5,6569 6 4,4721 4,2426 4 5,6569 4,8990 4,8990 5,4772 5,8310 5 5,9161 5,1962 4,2426 4 4 2,4495 2,8284 4 0 4 4 5,0990 4,8990 3,3166 4,4721 4,6904 4,2426 4 4,2426 4,1231 5,3852 5,3852 6,1644 4,8990 5,4772 5,8310 6,3246 6,4807 5,8310 5,0990 4,8990 5,4772 5,2915 5,0990 5,4772 5,6569 5,8310 6,3246 6,1644 6,3246 6 6,3246 5,2915 6,4807 5,2915 5,6569 5,2915 4,8990 5,8310 6 5,8310 5,2915 5,2915 5,0990 5,8310 5,2915 6,6332 6,6332 6,4807 6 5,4772 5,6569 4,8990 6 5,8310 5,6569 5,2915 6 6 5,0990 5,2915 4,6904 5,6569 5,2915 5,2915 5,0990 5,4772 5,8310 6,1644 6,1644 5,0990 5,6569 6,3246 6,3246 5,0990 6,0828 6,0828 6,0828 6 6,3246 5,0990 5,4772 4,2426 5,8310 2,8284 5,2915 5,4772 5,6569 5 6,0828 5,5678 5,4772 5,0990 5,2915 4,2426 4,2426 4,6904 4 0 4,8990 5,8310 5,6569 4,7958 5,4772 5,8310 5,4772 3,7417 4 5,1962 5,7446 5,9161 6 5,0990 5,0990 5,8310 5,4772 5,8310 5,2915 5,2915 5,6569 5,8310 5,2915 5,0990 5,0990 5,6569 6,1644 6 6 6,3246 5,8310 6,1644 5,0990 6,3246 4,2426 4,8990 5,2915 4,6904 5,0990 5,6569 5,4772 5,0990 5,0990 5,6569 5,8310 5,6569 6,3246 6,3246 6 5,6569 5,0990 4,8990 5,4772 5,6569 6 5,8310 5,2915 5,8310 5,6569 4,8990 5,8310 5,4772 5,4772 5,2915 5,2915 6 6,1644 5,8310 6,3246 5,4772 5,2915 5,4772 5,2915 5,4772 5,2915 5,5678 6,0828 5,5678 6,6332 6,4807 5,4772 5,4772 5,4772 4,6904 5,6569 5,2915 5,4772 5,8310 5,3852 5,5678 6,0828 5,2915 5,0990 5,0990 4 4 5,0990 4 4,8990 0 5,6569 5,6569 4,5826 5,0990 5,2915 4,8990 4,4721 4,2426 5 5,9161 5,7446 6,4807 5,8310 5,6569 5,2915 5,0990 5,0990 4,6904 5,8310 6,1644 6,4807 5,8310 5,6569 5,4772 4,8990 5,6569 5,2915 5,2915 6 5,0990 5,4772 4,6904 5,2915 5,4772 5,0990 6 5,4772 5,8310 6,1644 6 5,8310 5,8310 6,1644 5,0990 6,1644 5,8310 5,8310 5,8310 5,0990 4,4721 4,6904 4,4721 4,4721 6,3246 6,3246 5,8310 6 6 5,6569 6,3246 6,1644 5,6569 6 5,8310 6,4807 6,1644 5,2915 6,1644 6,1644 5,8310 4,2426 4,4721 4,6904 4,6904 5,9161 6,5574 5,7446 6,9282 6,7823 6 6 6,1644 4,6904 5,6569 5,0990 3,7417 5,0990 5 6,7082 6,7082 5,6569 5,6569 5,6569 5,0990 4,8990 6 5,0990 5,8310 5,6569 0 2 5 5,6569 5,6569 5,0990 6,3246 6,1644 5 6,4031 6,2450 6,7823 6 5,8310 5,4772 5,0990 5,2915 4,8990 5,6569 6 6,3246 5,6569 5,6569 5,2915 4,6904 5,4772 5,0990 5,0990 5,8310 4,8990 5,2915 4,4721 5,0990 5,2915 4,8990 6,1644 5,2915 6 6,1644 6,1644 5,6569 5,6569 6 4,8990 6,3246 5,6569 5,6569 5,4772 4,8990 4,4721 4,4721 4,2426 4,2426 6,4807 6,4807 5,6569 6 6,1644 5,4772 6,1644 6 5,4772 5,8310 5,6569 6,3246 6 5,0990 5,8310 6 5,6569 4,2426 4,6904 4,4721 4,2426 6,0828 6,7082 5,9161 6,7823 6,9282 5,8310 5,8310 6 4,8990 5,4772 4,8990 4 5,2915 4,7958 6,8557 6,5574 5,4772 5,4772 5,4772 4,6904 5,0990 5,8310 4,8990 5,6569 5,6569 2 0 4,7958 5,8310 6 5,2915 6,1644 6,3246 5,1962 6,5574 6,2450 5,3852 4,7958 4,5826 5,5678 5,1962 5,3852 5 4,3589 5 5,1962 4,3589 4,3589 4,3589 4,7958 5,1962 5,1962 4,7958 5,7446 5 5,3852 4,5826 5,7446 5,3852 5 5 3,8730 4,3589 4,5826 5,0000 3,8730 4,3589 4,3589 5 4,7958 5,7446 5,7446 5,1962 5 4,1231 4,5826 5 4,7958 5 4,7958 4,3589 4,5826 4,7958 3,6056 5,1962 4,3589 4,7958 4,5826 4,3589 4,7958 5 5,1962 5,9161 6,2450 5 5 5,3852 5,1962 5 4,6904 5,6569 5,0990 5,5678 5,7446 4,3589 4,5826 4,3589 5,9161 5,1962 5 5,3852 5,3852 4,2426 5,4772 4,8990 4,3589 4,3589 4,3589 3,3166 3,6056 4,5826 3,3166 4,7958 4,5826 5 4,7958 0 4,7958 4,5826 3,8730 5 5,1962 3,1623 5,2915 4,8990 5,4772 4,8990 5,0990 6 5,8310 6 5,2915 5,2915 5,6569 5,0990 5,2915 5,2915 5,2915 5,4772 6,3246 6,1644 6 6,3246 5,8310 6,1644 5,0990 6,3246 6 5,4772 5,4772 4,8990 4,2426 5,0990 4,6904 5,2915 5,2915 5,6569 5,6569 5,4772 6,1644 6,1644 6,1644 5,8310 5,2915 5,4772 5,8310 5,6569 5,8310 5,8310 5,0990 4 3,7417 4,8990 5,8310 5,2915 5,0990 4,6904 5,0990 5,8310 5,8310 6 6,6332 6,6332 5,8310 5,6569 6 6 6 5,5678 5,9161 5,3852 5,6569 4,8990 5,4772 5,2915 5,2915 6,1644 6 6,1644 6,0000 6,1644 5,9161 6,2450 6,0828 4 3,1623 3,1623 4,4721 4 4 4,4721 5,4772 5,0990 5,6569 5,8310 4,7958 0 2,4495 4,6904 5,0990 4,8990 4,5826 5,3852 5,5678 5,0990 5,2915 5,2915 6,1644 6 6,1644 5,6569 5,4772 5,8310 5,4772 5,4772 5,2915 5,4772 5,8310 6,1644 6,3246 6 6,4807 6,1644 6,4807 5,4772 6,4807 6,1644 5,8310 5,6569 5,0990 4 4,6904 4,8990 5,0990 5,4772 5,4772 6 5,4772 6,3246 6,3246 6 6 5,2915 5,8310 6,1644 5,8310 5,6569 5,6569 5,4772 3,7417 3,4641 4,8990 6,1644 5,2915 5,2915 5,0990 5,2915 5,6569 5,8310 6,1644 6,7823 6,7823 6,1644 5,6569 6,1644 6,1644 6,1644 5,5678 6,2450 5,7446 5,6569 5,0990 5,4772 5,4772 5,2915 6,3246 6,3246 6,3246 6,1644 6,1644 6,0828 6,2450 6,0828 4,4721 3,4641 3,7417 4,6904 4,4721 4,4721 4,6904 5,8310 5,2915 5,6569 6 4,5826 2,4495 0 4,8990 5,4772 5,2915 4,3589 5,7446 5,3852 5,8310 4,8990 4,6904 5,6569 5,2915 5,2915 5,0990 4,8990 5,4772 5,6569 4,8990 4,8990 4,4721 4,8990 6 5,0990 5,4772 6,1644 5,2915 5,2915 5,0990 6,1644 5,8310 5,4772 5,0990 4,4721 4,8990 5,4772 5,0990 4,8990 4,6904 5,2915 5,0990 5,2915 6,1644 6,1644 6 5,0990 4,6904 5,0990 5,4772 5,0990 5,4772 5,2915 4,8990 5,4772 5,2915 4,6904 5,4772 5,0990 5,2915 5,0990 4,8990 5,6569 5,8310 5,6569 6,1644 6,6332 5,4772 5,4772 5,4772 5,4772 5,2915 5,3852 5,9161 5,3852 6,1644 6 5,2915 4,6904 5,2915 6 5,6569 5,0990 5,4772 4,8990 5,1962 5,9161 5,7446 5,0990 5,0990 5,0990 4,2426 4 5,2915 4,2426 5,4772 4,8990 5,0990 5,2915 3,8730 4,6904 4,8990 0 5,2915 5,0990 4,1231 5,1962 5,3852 6,1644 4,6904 5,4772 5,8310 6,1644 6,3246 5,6569 5,0990 4,6904 5,0990 5,2915 4,8990 5,2915 5,6569 5,8310 6,1644 6 6 5,8310 6,1644 5,0990 6,1644 5,4772 5,4772 5,2915 4,6904 5,6569 5,8310 5,8310 5,0990 5,0990 5,0990 5,8310 5,2915 6,1644 6,1644 6 5,8310 5,2915 5,4772 5,2915 5,8310 6 5,8310 5,2915 5,8310 5,8310 4,8990 5,2915 4,6904 5,4772 5,0990 5,0990 4,8990 5,2915 5,6569 6,1644 6,3246 5,2915 5,4772 6,1644 5,8310 5,4772 5,9161 5,3852 5,5678 5,4772 5,8310 4,6904 5,4772 4,2426 6,1644 4,4721 5,4772 5,8310 6 5,3852 5,5678 5,5678 5,0990 4,8990 5,0990 4,4721 4,4721 4 4 3,7417 4,4721 6,3246 6,1644 5 5,0990 5,4772 5,2915 0 1,4142 5 5,3852 5,9161 6 4,4721 5,2915 5,6569 6 6,1644 5,4772 5,2915 4,8990 5,2915 5,4772 5,0990 5,4772 5,8310 6 6,3246 6,1644 6,1644 6 6,3246 5,2915 6,3246 5,6569 5,6569 5,0990 4,8990 5,4772 6 5,6569 5,2915 5,2915 5,2915 6 5,0990 6,3246 6,3246 6,1644 6 5,4772 5,6569 5,4772 6 5,8310 5,6569 5,4772 6 5,6569 5,0990 5,4772 4,8990 5,6569 5,2915 5,2915 5,0990 5,4772 5,8310 6,3246 6,4807 5,4772 5,6569 6 6 5,6569 5,7446 5,1962 5,3852 5,6569 5,6569 4,8990 5,6569 4,4721 6 4,6904 5,6569 5,6569 5,8310 5,5678 5,3852 5,7446 5,2915 5,0990 5,2915 4,6904 4,2426 4,2426 4,2426 4 4,2426 6,1644 6,3246 5,1962 4,8990 5,2915 5,0990 1,4142 0 4,7958 5,1962 5,7446 5,5678 4,7958 4,7958 5,7446 5,3852 5,5678 5,1962 5,1962 5,5678 5,7446 5 5 5 5,3852 5,7446 5,7446 5,3852 6,0828 5,5678 5,9161 5,1962 6,0828 5,5678 5,5678 5,1962 4,5826 4,5826 5,1962 5,1962 4,5826 5 5 5,5678 5 5,9161 5,9161 5,3852 5,5678 4,7958 5,1962 5,1962 5,3852 5,3852 5,1962 5 5 4,7958 4,3589 5,7446 5 5,3852 5,1962 4,7958 5,1962 5,3852 5,7446 6,4031 6,2450 5,1962 5,5678 5,5678 5,3852 5,1962 4,8990 5,4772 4,8990 5,7446 5,5678 5 5,1962 5 5,7446 5,3852 5,3852 5,1962 5,1962 4,6904 5,4772 5,4772 4,7958 4,7958 4,7958 4,3589 4,1231 5 4,1231 5,1962 5 5 5,1962 3,1623 4,5826 4,3589 4,1231 5 4,7958 0 5,2915 4,8990 5,5678 4,3589 4,7958 5,1962 6,0828 6,2450 5 4,7958 4,7958 4,7958 5 5 4,7958 5,3852 5,5678 6,5574 6,5574 6,0828 6,4031 6,2450 5,5678 6,2450 6,4031 5,9161 5 5 5,3852 5,5678 5,5678 5,3852 5 4,5826 5,5678 4,3589 6,0828 6,0828 6,2450 5,5678 5,7446 6,0828 6,2450 6,2450 5 5 4,7958 5,7446 5,3852 4,5826 4,1231 4,5826 5,7446 5,3852 5,1962 5,1962 4,7958 5,7446 5,9161 7,1414 6,0828 6,0828 6,4031 6,5574 6,2450 5,0990 4,2426 4,8990 5,1962 4,7958 4,3589 5,3852 5,3852 6,7082 6,0828 6,5574 6,4031 6,0828 6,1644 5,2915 4,8990 5,5678 5,7446 5,9161 5,3852 5 5,1962 5,3852 5,7446 5,9161 6,4031 6,5574 5,2915 5,3852 5,7446 5,1962 5,3852 5,1962 5,2915 0 4 5 4,5826 4,7958 5 5,7446 6,0828 5 4,5826 5 5,3852 5 5 4,7958 5,3852 5 6,4031 6,2450 5,7446 6,4031 6,2450 5,5678 6,0828 6,2450 5,9161 5 5 5 5,1962 5,5678 5 5 4,3589 5,5678 4,3589 5,9161 5,9161 5,5678 5,3852 5,5678 6,0828 6,2450 6,0828 4,5826 4,1231 5 5,3852 5,1962 4,7958 4,5826 4,5826 5,5678 5,5678 5,1962 5 4,5826 5,7446 5,5678 7 6,2450 5,9161 6,2450 6,4031 5,9161 4,6904 5,2915 4,8990 5,9161 5,5678 5 5,5678 5,3852 6,5574 6,0828 6,4031 6,2450 5,9161 6 5,4772 4,6904 6,0828 5,9161 5,9161 5,1962 5,1962 5,7446 5,3852 5,9161 5,7446 6,2450 6,2450 4,8990 5,5678 5,3852 5,3852 5,9161 5,7446 4,8990 4 0 The milestone of the year 2013: At the end of Another great step towards becoming competent­ But CeMM also has strong ties to its brother 2013, Robert Kralovics’ group, in collaboration­ in a translational sense has been the ­installation organization of the Austrian Academy of with the group of Heinz Gisslinger of the Medical of the Christian ­Doppler Laboratory for ­Sciences, the Institute for Molecular Bio­tech­ University of Vienna, published the ­identification ­Chemical Epigenetics and Anti-Infectives,­ nology IMBA, close to the IMP. Despite some CeMM of a long-missing piece of a genetic puzzle that ­masterfully ­set-up and led by Stefan Kubicek and chivalric rivalry that is typical and healthy he had been trying to assemble for many years. ­representing a collaboration with the companies among loving siblings, mostly taken out on This long sought-after gene is affected­ in all Boehringer Ingelheim and Haplogen. We wish the soccer ground, we are exploiting synergies­ Research those patients having one of the several forms to thank the President of the Christian Doppler and ­collaborations whenever feasible and help of the cancer-like disease of the blood called Research Association, Reinhart Kögerler, for the each other out as much as possible. CeMM Myeloproliferative Neoplasms­ (MPNs), that did trust put by the Association into CeMM. has a deep admiration for its slightly older and not carry a ­mutation in the ­other main gene of larger ­brother. This peaked as the team of Jürgen Report these disorders, Jak2 that Robert had identified CeMM has been inspired in many ways by Knoblich published the ­amazing ­achievement back in 2005 or the ­thrombopoietin receptor the pioneering activities of the Institute for of developing complex human brain tissue in a gene. The new gene, encoding the protein called ­Molecular Pathology IMP that I witnessed from three-dimensional culture system, popularly calreticulin, is ­mutated in an interesting way, not the days of its conception as a “­founding ­student” called “mini brains”. We ­immediately posted 2013 causing a loss of its function, but changing the ­following Max L. Birnstiel and my ­mentor the news on the CeMM web site to ­congratulate ­functionality of the protein. This was entirely ­Meinrad Busslinger from Zurich to Vienna. Jürgen and IMBA. It does not ­happen often unexpected and sheds an entirely new light on The impact that the IMP has had on the Austrian that the community perceives that one of its Introduction by Giulio Superti-Furga ­fundamental processes of cell biology. So it has a research landscape in the life sciences cannot achievements has historical dimension and strong impact on basic research. But the ­finding be overestimated in its immensity. We join ­acknowledges it. This is great for Vienna, is ­particularly remarkable for its immediate the community that expressed its ­gratitude to ­Austria and the Academy of Sciences and we impact on medicine. We estimate that hundreds Max Birnstiel who celebrated its 80th ­birthday feel that 2013, through this work but also Robert of ­thousands of patients in the world carry the in the summer and on behalf of CeMM now ­Kralovics’, can definitely be identified as the year mutant ­calreticulin gene and based on Robert’s express once more our admiration for Max when molecular biology in Austria has reached results can now have a molecular diagnosis and renew our wishes. We also congratulate a truly planetary standing. We feel that it is very for their condition. Although targeted therapy Jan-Michael Peters on taking the helm of the appropriate that the community will take the for ­calreticulin will only be possible once we IMP with ­auspices of yet more collaboration 50th anniversary of the European Molecular develop further an initial concept that Robert just between the two institutes.­ Biology Organization and 40th anniversary ­conceived, the current optimal pharmacological­ of the ­European Molecular Biology Laboratory regimen for calreticulin patients is slightly to celebrate the impact of molecular biology on ­different than from Jak2 ­positive patients. Thus, ­Austria, on July 7th and 8th 2014. personalized therapy through CeMM’s research is a reality now. 2013, therefore, can be considered a Besides CeMM’s first important steps as trans­ turn-around year for CeMM, its first ­translational lational center, there were other important milestone has been reached. I congratulate ­Robert signs of maturity of CeMM worth ­highlighting. Kralovics and the ­formidable CeMM PhD ­student For some years we have engaged artists, ­Thorsten Klampfl who has persisted in the quest, ­philosophers, historians, economists, physicist as well as the entire team involved. But I also and others to help us abandon the intellectual wish to ­congratulate the ­scientists at CeMM’s boundaries of our discipline and learn about 7th floor that have ­contributed to the rapid and new territories. Brain Lounge sessions are often ­professional ­establishment of genomic ­sequencing ­unrepeatable little feasts of cerebral exchange and human ­mutation ­mapping, ­Christoph Bock, and the SMART lectures represent a kind of Kaan ­Boztug and their groups and the entire BS ­intellectual challenge that we learned to crave ­facility, ­operated in ­collaboration with the Medical for. On November 25 we had the pleasure of ­University of Vienna. ­welcoming Fabiola Gianotti (CERN Physics Department, Large Hadron Collider). She gave the 2nd SMART lecture on “The Higgs Boson and Our Life” and fascinated 200 scientists from different fields and interested lay people with her brilliant talk.

Giulio Superti-Furga on a "Chair to Share" by Dorothee Golz­

Ce — M­—M­— Research Report 2013 Science 4 5 We also make a big effort with our Research Fostering a whole new quality in the dialogue At that time the institute was highly ­innovative, This year has seen one of the key people to turn Reports as we always felt that CeMM has, from with other disciplines and in the awareness for maybe world-unique in its focus. After the the CeMM idea into reality, Gerhard Schadler, its inception, a role that was larger than “just” the societal impact of biomedical research and ­initial twenty years, the research center joined its administrative director, move on to fresh excellent biomedical research. The genomic the importance of interdisciplinary and cross- the Academy of Sciences, was then made ­challenges. He assumed a new role in the era and the accompanying changes in the way cultural approaches, people at CeMM developed first ­Jew-free, then made to host distorted or ­Academy of Sciences to help the newly elected humankind understands itself go way beyond a new sense of accountability to society. So ­irrelevant science and, perhaps ­surprisingly, Board to manage the Academy. While Gerhard the medical revolution it is generating. Thus, our instead of doing the yearly CeMM outing in was not restarted after the damages of the war. maintained some responsibilities until the end of reports are a bit more like cultural manifestos one of the picturesque sites of local cultural ­Curiously, it also had disappeared from our 2013, the responsibility for ­administration went that witness and pay tribute to these pivotal, ­heritage, it was time to engage a more serious historical conscience: At least at CeMM we had entirely to Anita Ender. Anita has been ­ultimate paradigm-changing years. CeMM’s 2013 research theatre. 2013 has marked the 75th ­anniversary been oblivious of the existence of this proto- decision-maker on so many ­administrative issues report inaugurates a different format. We now of Hitler’s “Anschluss” with the Nazi takeover life science institute. It became clear, also from for so long that sanctifying this role appeared offer you information in different coherent in Austria and the November Pogrom. The the symposium in the Academy, that crimes long due and well deserved. We are very much ­sections, to provide for an easier reading of the Austrian ­Academy of Sciences has organized a against Jewish scientists and non-conformists indebted with Gerhard for all these years of various components. highly interesting symposium on the ­history of clearly preceded 1938 and that much of that work for CeMM and, on behalf of everybody at the Academy 1938-1945 on March 11 of this year, many ­post-war failures and omissions were also CeMM, wish him all the best in the new function. To “present” the year we built on a wonderful­ ­during which the ­president of the parliament­ brutal. The Mauthausen visit sparked a yet new I also wish Anita good fortune in her enlarged example of our dialogue with society. One ­Barbara Prammer has unveiled a marble discussion culture at CeMM and we all felt that role. This has been a year of great structural and of our befriended artists, Dorothee Golz, ­memorial commemorating the ­victims of the ­awareness about the importance of safeguarding­ organizational changes, so next to a new Board who contributed to the CeMM Brain Lounge Nazi crimes. key ­values that should go hand in hand with of the Academy and a new chief administrator, (see 2012 Research Report), approached me research endeavors of an international, ­inclusive we also have, most importantly, a new Minister with the idea of having a geneticist collaborate Though CeMM is an institution­ of the third and d­emocratic science community. We all of ­Science, Research and Economy, Dr. Reinhold with her to unravel the traits in a particular ­Millennium, it has its roots in the ­Academy felt very priv­ileged to live in Austria and in the Mitterlehner, whom we welcome and wish branch of the body of her oeuvre that allows for of Sciences and the ­Medical Faculty of the 21st century. ­wisdom, far-sight and deep pockets. a proper “­genealogy”. What ensued is presented ­University and it felt doubly motivated to engage in this report and represents a first-ever formal with the darkest period of its ­history. At CeMM CeMM is a community conscious of its social Beyond our regular Scientific Advisory Board ­quantitative representation of the relationship we are ­providing for training of young scientists­ responsibility regarding the past, the present visits, 2013 was a year in which CeMM’s research among the works of an artist. The conceptual from all over the world and that ­training includes but also the future. For example, of the roughly has been evaluated twice. First, on behalf of the breakthrough that Dorothee achieved can inspire exposure to knowledge and understanding 140 individuals who every day come to work in Austrian Academy of Sciences, by a panel of everybody, also scientists, to create a map of their outside the ­classical realm of ­natural science the CeMM building, nobody takes a car. A third international experts lead by Adriano Aguzzi own creations (ideas, papers, patents, ­companies, and medicine. It appeared ­important to convey takes bicycles, scooters or walks and the rest of the ­University of Zurich. Later we were also projects, songs, clothes, design objects, brands, an ­understanding of the cultural context of takes public transport. It saddens me to see that evaluated by Technopolis, a professional group products etc). It offers an abstraction of one’s Austria that goes beyond the entertainment people entering the AKH campus on Spitalgasse providing advice to policy makers, that reviewed own creativity and may predict work of the and we ­proposed to the “­CeMMies” to visit the have no pedestrian crossing and as they step the entire genomics program Gen-AU for the future. So, the Brain Lounge that we presented Mauthausen concentration­ camp. The idea was out of the trams are de-routed to a complex and Research Ministry (Gen-AU unfortunate­l­y to you last year, with its revolving carousel and welcomed and we combined the guided visit, in time-­costing system of traffic lights. We still already ended). While we have not received the interactive community that come to think groups of ten, with a seminar in the building of have the hope that the city will invest in a new any written reports from the two evaluations, on it, has created a highly exciting baby. We the ­Academy of Sciences, where ­undoubtedly traffic control and information system on the we received a very positive oral feed-back, thank ­Dorothee Golz for using CeMM to test some of the ­racist discriminations and worse campus which will be of the benefit of thousands enjoyed the discussions with the various experts her idea, for sharing her work with us and for deeds had been ­perpetrated. The entire CeMM of ­students, employees and patients. ­thoroughly and profited very much from the the ­inspiration that emanates from her creative team was ­welcomed by the newly elected advice. We wish to thank both teams. thrust. ­President of the Austrian Academy of Sciences, Anton Zeilinger and the seminar was given by Finally I would like to thank Stefanie Lichtwitz, journalist and ­historian Klaus Taschwer on the Kriso Leinfellner and their team for ­conceptually “Biologische Versuchanstalt”, an institute on insightful and beautiful graphics and Helen experimental biological research founded in 1903 Pickersgill for once again skilfully writing the by Jewish scientists and philanthropists led by scientific part of the report. Over again, it has Hans Leo Przibram. been Eva Schweng, the editor and coordinator of all this effort, that deserves my and CeMM’s applause. I hope you will enjoy this new account of the intellectual journey we are doing together with our readers and supporters. This, ladies and gentlemen, was our 2013.

Giulio Superti-Furga Scientific Director [email protected]

Ce — M­—M­— Research Report 2013 Science 6 7 PX 66

Bezeichnung PX66 Wichtigkeit normal Generation 5 Bruderpaar nein Aehnlichkeit nein Groesse gross Haptik hart Position_allgemein steht Position_detail steht Material Papierpaste Aufbau gebaut Aufbau_detail gebaut Farbe weiss Farbbasis Materialfarbe Farbkombination nein Zweites_­Material nein Einsatz_allgemein nein Einsatz_detail1 nein­ Einsatz_detail2 nein ­ Ironie nein Biomorph biomorph Biomorph_detail ­biomorph_tailliert Schnorchel_allgemein nein ­ Schnorchel_detail1 nein Schnorchel_detail2 nein DUO_Gruppe single Oeffnung_allgemein ­geschlossene_Form Oeffnung_detail geschlossene_Form Formmerkmal nein Halbkugel nein Gereiht nein Konvex nein Konkav nein Voluminoes voluminoes Oberflaeche glatt Struktur nein Sockel nein Beine nein Zusatztitel ja

Dorothee Golz, 2006 Paper pulp, white chalk 85 x 125 x 148 cm PX 70

Bezeichnung PX70 Wichtigkeit normal Generation 5 Bruderpaar nein Aehnlichkeit Aehnlich_PX29 Groesse klein Haptik hart Position_allgemein steht Position_detail steht Material Paste Aufbau gebaut Aufbau_detail gebaut Farbe rot Farbbasis Farbauftrag­ Farbkombination nein Zweites_­Material Plexiglas Einsatz_allgemein nein Einsatz_detail1 ­nein Einsatz_detail2 nein ­ Ironie nein Biomorph nein Biomorph_detail ­nein Schnorchel_allgemein nein ­ Schnorchel_detail1 nein Schnorchel_detail2 Schnorchel_Aufsatz DUO_Gruppe single Oeffnung_allgemein ­geschlossene_Form Oeffnung_detail geschlossene_Form Formmerkmal 2_Spoiler Halbkugel nein Gereiht nein Konvex nein Konkav nein Voluminoes flach Oberflaeche glatt Struktur nein Sockel Sockel Beine nein Zusatztitel nein

Dorothee Golz, 2013 Acrylic plaster, distemper, acrylic glass 33 x 25 x 8 cm PX 74

Bezeichnung PX74 Wichtigkeit normal Generation 5 Bruderpaar nein Aehnlichkeit nein Groesse klein Haptik hart Position_allgemein haengt Position_detail haengt_ohne_Abstand Material Gips Aufbau abgegossen Aufbau_detail abgegossen Farbe gelb Farbbasis Farbauftrag­ Farbkombination gelb/weiss Zweites_­Material nein Einsatz_allgemein nein Einsatz_detail1 nein Einsatz_detail2 nein ­ Ironie nein Biomorph nein Biomorph_detail nein Schnorchel_allgemein nein ­ Schnorchel_detail1 nein Schnorchel_detail2 nein DUO_Gruppe single Oeffnung_allgemein ­geschlossene_Form Oeffnung_detail geschlossene_Form Formmerkmal Loch Halbkugel Halbkugel Gereiht gereiht Konvex konvex Konkav nein Voluminoes flach_voluminoes Oberflaeche glatt Struktur nein Sockel nein Beine nein Zusatztitel nein

Dorothee Golz, 2013 Acrylic plaster, distemper, acrylic glass 12,5 x 12,5 x 6,5 cm PX1 PX2 PX3 PX4 PX5 PX51 PX53 PX54 PX52 PX55

PX6 PX7 PX8 PX9 PX10 PX56 PX57 PX59 PX60 PX58

PX13 PX14 PX15 PX61 PX62 PX11 PX12 PX63 PX64 PX65

PX16 PX18 PX19 PX20 PX66 PX67 PX68 PX70 PX17 PX69

PX22 PX25 PX72 PX23 PX24 PX71 PX73 PX74 PX75 PX21

PX26 PX27 PX28 PX29 PX30 PX76 PX77 PX78 PX79 PX80

PX31 PX33 PX34 PX35 PX81 PX82 PX85 PX32 PX83 PX84

PX37 PX38 PX39 PX40 PX86 PX87 PX88 PX89 PX90 PX36

PX41 PX42 PX43 PX44 PX45 PX91 PX92 PX93 PX94 PX95

PX Series Dorothee Golz 1989–2013

PX46 PX47 PX49 PX50 PX96 PX97 Freie Form A Freie Form B PX48 frei_B frei_A Encoding of Art Encoding Quantitative PX97 PX96 PX95 PX94 PX93 PX92 PX91 PX90 PX89 PX88 PX87 PX86 PX85 PX84 PX83 PX82 PX81 PX80 PX79 PX78 PX77 PX76 PX75 PX74 PX73 PX72 PX71 PX70 PX69 PX68 PX67 PX66 PX65 PX64 PX63 PX62 PX61 PX60 PX59 PX58 PX57 PX56 PX55 PX54 PX53 PX52 PX51 PX50 PX49 PX48 PX47 PX46 PX45 PX44 PX43 PX42 PX41 PX40 PX39 PX38 PX37 PX36 PX35 PX34 PX33 PX32 PX31 PX30 PX29 PX28 PX27 PX26 PX25 PX24 PX23 PX22 PX21 PX20 PX19 PX18 PX17 PX16 PX15 PX14 PX13 PX12 PX11 PX10 PX9 PX8 PX7 PX6 PX5 PX4 PX3 PX2 PX1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Wichtigkeithoch 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Wichtigkeitnormal 1 1 1 1 1 1 1 Generation1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Generation2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Generation3 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Generation4 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Generation5 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Generation6 1 1 1 1 1 1 Generation7 1 1 Generationkeine 1 1 BruderpaarBruder_PX35 1 1 BruderpaarBruder_PX42 1 1 BruderpaarBruder_PX46 1 1 BruderpaarBruder_PX8 1 1 BruderpaarBruder_PX81 1 1 BruderpaarBruder_PX89 1 1 BruderpaarBruder_PX92 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Bruderpaarnein 1 1 AehnlichkeitAehnlich_PX14 1 1 AehnlichkeitAehnlich_PX29 1 1 AehnlichkeitAehnlich_PX3 1 1 AehnlichkeitAehnlich_PX32 1 1 AehnlichkeitAehnlich_PX34 1 1 1 1 AehnlichkeitAehnlich_PX41 1 1 AehnlichkeitAehnlich_PX43 1 1 AehnlichkeitAehnlich_PX44 1 1 AehnlichkeitAehnlich_PX45 1 1 1 1 AehnlichkeitAehnlich_PX46 1 1 1 AehnlichkeitAehnlich_PX47 1 1 1 1 AehnlichkeitAehnlich_PX53 1 1 AehnlichkeitAehnlich_PX54 1 1 AehnlichkeitAehnlich_PX58 1 1 1 AehnlichkeitAehnlich_PX63 1 1 AehnlichkeitAehnlich_PX73 1 1 1 AehnlichkeitAehnlich_PX77 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Aehnlichkeitnein 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Groessegross 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Groesseklein 1 1 1 1 1 1 1 1 1 1 Groessemittel 1 1 1 1 Groesseriesig 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Haptikhart 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Haptikweich 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Position_allgemeinhaengt 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Position_allgemeinsteht 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Position_detailhaengt_mit_Abstand 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Position_detailhaengt_ohne_Abstand 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Position_detailsteht 1 1 1 1 MaterialBeton 1 1 1 1 1 1 1 1 1 1 1 1 1 MaterialGips 1 1 1 1 1 1 MaterialKunstleder 1 1 1 1 MaterialPapierpaste 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 MaterialPaste 1 1 1 1 1 MaterialPlastik 1 1 MaterialPolyester 1 1 1 1 1 1 1 1 1 1 MaterialSilikon 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Aufbauabgegossen 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Aufbaugebaut 1 1 1 1 1 1 1 1 1 1 1 Aufbaugenaeht 1 Aufbaulaminiert 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Aufbau_detailabgegossen 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Aufbau_detailgebaut 1 Aufbau_detailgebaut_gefuellt 1 1 1 1 Aufbau_detailgenaeht_gefuellt 1 1 1 1 1 1 1 Aufbau_detailgenaeht_hohl 1 Aufbau_detaillaminiert_gefuellt 1 1 1 1 1 1 1 1 Farbeblau 1 Farbebunt 1 1 FarbeFarbe_X 1 1 1 1 1 1 1 Farbegelb 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Farbegrau 1 Farbegruen 1 Farbegrün 1 Farbehellgruen 1 1 Farbemilch 1 1 1 1 1 1 1 1 Farbeorange.rot 1 Farberosa 1 1 Farberot 1 1 1 1 1 Farbeschwarz 1 1 1 1 1 Farbeunbekannt 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Farbeweiss 1 1 1 1 1 1 1 1 1 1 1 1 Farbbasisfabric 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 FarbbasisFarbauftrag 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 FarbbasisMaterialfarbe 1 1 1 1 FarbbasisMetallbeine 1 1 FarbbasisPU.gruen 1 FarbbasisSilikon.gruen 1 1 1 1 Farbbasisunbekannt 1 1 Farbkombinationblau.orange 1 1 Farbkombinationgelb.weiss 1 1 Farbkombinationgrau.gruen 1 Farbkombinationgrau.milch 1 Farbkombinationgrau.weiss 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Farbkombinationnein 1 1 1 Farbkombinationweiss.milch 1 1 Zweites_MaterialHolzkiste 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Zweites_Materialnein ­history, evolutionary analysis can illuminate genetic fingerprints tounderstand natural Similar tobiologists who study fossils and in aHigh-DimensionalMatrix Encoding theCharacteristics ofthePXObjects 1 1 1 Zweites_MaterialPlexiglas 1 Zweites_MaterialPVC.Folie 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Einsatz_allgemeineinfach 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Einsatz_allgemeinnein 1 1 1 1 1 Einsatz_detail1Einsatz_Ausguss 1 1 Einsatz_detail1Einsatz_Glaslinse 1 Einsatz_detail1Einsatz_M1 1 Einsatz_detail1Einsatz_M2 1 Einsatz_detail1Einsatz_M3 1 Einsatz_detail1Einsatz_M4 1 1 Einsatz_detail1Einsatz_Noppen 1 1 Einsatz_detail1Einsatz_Schlauch 1 1 Einsatz_detail1Einsatz_Staender 1 1 1 1 Einsatz_detail1Einsatz_Ventil 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Einsatz_detail1nein 1 1 Einsatz_detail2Einsatz_Glas 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Einsatz_detail2Einsatz_Metall 1 1 1 1 Einsatz_detail2Einsatz_Mutation 1 Einsatz_detail2Einsatz_NA 1 1 1 Einsatz_detail2Einsatz_Plastik 1 1 Einsatz_detail2Einsatz_Schaumgummi 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Einsatz_detail2nein 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 IronieIronie 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Ironienein 1 1 1 1 1 1 1 1 1 1 Biomorphbiomorph 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Biomorphnein 1 1 1 1 Biomorph_detailbiomorph_andere 1 1 1 1 1 1 Biomorph_detailbiomorph_tailliert 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Biomorph_detailnein embraces theconceptsof mutation and ­evolutionary analysis because the artist explicitly ­Dorothee Golzisparticularly suitedfor an of art. The PX seriesof sculptural objectsby principles and processesinvolvedinthecreation 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Schnorchel_allgemeinnein 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Schnorchel_allgemeinSchorchel 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Schnorchel_detail1nein 1 1 1 1 1 1 1 1 1 Schnorchel_detail1Schnorchel_schmal 1 1 1 1 1 1 1 1 Schnorchel_detail1Schnorchel_Variation 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Schnorchel_detail2nein 1 1 Schnorchel_detail2Schnorchel_Aufsatz 1 Schnorchel_detail2Schnorchel_Metall 1 1 1 1 Schnorchel_detail2Schnorchel_rund 1 1 1 1 1 1 1 1 1 Schnorchel_detail2Schnorchel_schmal 1 1 1 1 1 1 1 1 1 1 DUO_GruppeDuo 1 1 1 1 1 1 DUO_GruppeGruppe 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 DUO_Gruppesingle 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Oeffnung_allgemeingeschlossene_Form 1 1 1 1 1 1 1 1 1 1 1 1 Oeffnung_allgemeinHuelle 1 Oeffnung_allgemeinMutationA 1 Oeffnung_allgemeinMutationB 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Oeffnung_detailgeschlossene_Form 1 1 1 1 1 Oeffnung_detailHuelle_gefuellt 1 1 1 1 1 1 1 Oeffnung_detailHuelle_leer 1 Oeffnung_detailMutationA 1 Oeffnung_detailMutationB 1 1 1 1 Formmerkmal2_Spoiler 1 1 FormmerkmalHoehle 1 FormmerkmalKombination 1 1 1 1 1 FormmerkmalLoch 1 1 1 1 1 1 1 1 1 1 Formmerkmalmittiger_Einsatz 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Formmerkmalnein 1 1 1 1 1 1 1 FormmerkmalVertiefung binary matrix that isdepictedhere. encoded in­ tative ­bio ­recombination that is also at thecoreof 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 HalbkugelHalbkugel 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1

Halbkugelnein logical evolution. To preparefor a quan­ 1 1 1 1 1 1 1 1 1 1 Gereihteinfach 1 1 1 1 1 Gereihtgereiht ­analysis, all 99PX objects were first 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Gereihtnein 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Konvexkonvex feature vectors, resultinginthe 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Konvexnein 1 1 1 1 Konkavkonkav 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Konkavnein 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Voluminoesflach 1 1 1 1 1 1 1 1 1 1 1 1 1 Voluminoesflach.voluminoes 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Voluminoesvoluminoes 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Oberflaecheglatt 1 1 1 1 1 1 1 1 1 Oberflaechestruktur 1 StrukturMuta1 1 StrukturMuta2 1 StrukturMuta3 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Strukturnein 1 1 1 1 StrukturNoppen 1 1 StrukturRillen 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Sockelnein 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 SockelSockel 1 1 1 1 1 1 1 1 1 BeineBeine ti­ 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Beinenein 1 1 1 1 1 1 1 1 1 1 Zusatztitelja 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Zusatztitelnein PX87 Hidden

PX73 Patterns PX77 Detecting Implicit Patterns in the PX Object Series through Statistical Analysis The binary matrix (depicted on PX76 PX72 PX88 PX74 PX41 the previous page) defines the position of each PX object in a PX96 PX75 179-dimensional hypercube – a hypercube is the generalization of three-dimensional cubes to ­arbitrarily high dimensions. PX95 While hypercubes are not easy PX97 to ­imagine visually, they are PX23 straightforward to analyze by PX63 Position_haengt ­statistical methods and helpful PX84 for uncovering hidden patterns in the data. Using a method called PX92 Halbkugel_ja ­“singular value decomposition”, PX81 a two-dimensional mapping of Konvex_ja trends and associations was PX93 PX82 Oeffnung_allgemeingeschlossene_Form PX83 PX89 obtained, which is shown here. PX91 PX94 This “biplot” identifies expected PX71 PX85 and new insights into the PX PX78 PX59 Volumen_flach PX90 sculpture series. For example, the Farbbasis_Farbauftrag Generation6 arrows indicate that objects from PX80PX86Generation5 recent generations (Generation5, Material_Gips PX58 Generation6) are essentially all Material_Paste Haptik_hart Wichtigkeit_hoch Aufbau_abgegossen wall-mounted and flat, in contrast Groesse_gross PX40 to earlier generations – ­suggesting PX47 Voluminoes_flach-voluminoes a recent increase of evolutionary pressure to produce wall-­mounted Aufbau_gebaut PX68 Farbe_weiss PX67 PX29 PX50 Sockel_nein sculptures. Schnorchel_ja DUO_Gruppe_single Farbkombination_nein Biomorph_nein Ironie_nein PX2 PX70 Bruderpaarnein Farbbasis_Materialfarbe PX46 Einsatz_nein Einsatz_einfach Groesseklein PX61 PX27 PX53 BeineneinPX39 PX24 PX54 Ironie_ja Zusatztitelnein PX62 PX52PX25 Zweites_Materialnein Generation4 Schnorchel_nein PX21 PX44 Sockel_ja PX26 Formmerkmalnein PX34 PX43 PX48 PX3 PX45 PX42 PX69 Oberflaeche_glatt Konkav_nein PX33 PX14 Struktur_nein PX66 PX1 Generation3 PX7 PX65 PX31 Wichtigkeit_normal PX79PX32 PX64 PX30 PX51 PX60 PX55 Farbe_grau Haptik_weich PX11 PX10 PX56 PX8 Generation2 PX28 PX49 PX4 Aufbau_genaeht PX12 Volumen_voluminoes PX9 Farbbasis_fabric Halbkugel_nein PX38 PX13 Oeffnung_allgemeinHuelle Konvex_nein Gereiht_nein Aehnlichkeit_nein Position_steht PX19 PX15 PX17 PX5 PX22 PX6 PX16

PX20

PX57 PX37

PX18

PX35 Ce — M­—M­— Research Report 2013 PX36 Science 18 19 PX87 Predicted PX73 PX77 Objects Predicting New Objects that Fill Holes in the Space of PX Objects PX96 Having constructed a statistical PX88 PX76 PX72 model that describes the inherent PX41 characteristics of the PX series PX95 PX75 as it stands today, it becomes R184 PX74 ­possible to predict new objects that could extend the series in R889 R539 a consistent and complementary R346 manner. 1000 potential PX objects R384 were generated by the computer PX97 PX23 and are visualized (in grey) R712R878 PX63 ­relative to the 99 existing PX R50R501R812 R735 R726R239 objects (in black). Furthermore, R519 R600 R183 all objects were computationally R651 R158R619 R3 R118 R926R431R25 R819 R89 R229 ranked by their expressiveness R250 R742 R547R276 and novelty, and the top-50 PX92 PX84 R897 R161 R133 R112 R695 potential objects are highlighted PX78 R97 R108 R134R479R779R124 PX82 R515R511R693 R524 in red. These top-ranking pre­ R576 R667R498 R6 PX93R24 PX81 PX94 R839R42 R1 dictions, the basic design has R854 R974R826 R403R366R226 R238 been reported back to the artist, PX71R546 PX91 R54R772R300R791 R104R937R152 R363R249R924 R510R538 R983R85 R329R602R483 PX59 R643R591 PX89 who will use this information to R296R837R753 PX83 R991 R775R343 R641R287 R493R581 R268 R455R940R754 R101 R870 R30 R733 potentially extend the PX series R948 R957R543R853R672R516R358R827 R521R664R952R232R52R460 R994PX85 R129R668R978R218R799R646 R76R809R958R8R841R155R792R215 R962 in directions that may not have R144 R157R337 R888 R648 R825R832R309R986R71 R802R62 R136R610 been obvious otherwise and R671 R267 R816 R566R805 R580R830R376R906R231 R845R608R687 R760 R381 PX90 R378 R941 R996PX86R454R321R734R458R51R252R880R286R848R529R392R968R990R364 R534 thereby increase the density of R471 R258R949R907PX80R965R182R875R999R681R862R28R383R22R967R45R901R988R156R494R283R79R354R303R947 PX58 R784 R47 R439R865R470R881R718R279R852 R438R964R738R480R730R295R723R275R221R489R728R654R715R35R58R589R166R412 R755 this ­sculptural language. R37 R333R77R191R361R293R631R674R44R785R339R700R224R526R148R209R843R540 R625R806R400R554 R552R87 R627 R857R294 R763R430R487 R765R406R318R936R408R449R425 R265 R274R423R595R255 R34 R395 R357 R284R233 R788R545R59R655R954R944R771R102R94 R131R781 R615R348 R164 PX40 PX68 R579R485R452R107R314R804R689R18R953R513R72R177R649R956R349R820 R453R594 R943 R20 R656 R752 R345R235R838R170 R269R222R472R635R592R387R119R613R256R141R583R890R394R617R310 R950R168R442R628 R945 R601 PX67 PX47 R834R399R165 R982R998R140R708R612 R663R311R463R273R424 R405R858R234 R912R732R872 PX50R864R421 R113R411R151R677 R505R903R81R893R867R365R114R939R860R111 R680 R884R507R597R351R180R624R803R632R966 R216R981 R622 R535 R500 R751 R993R692R497 R757R914R462R123R73R360R341R836R684R705R652R768R678 R756R676 R721 PX29 R647R520 PX70R811R459 R120R476R185R790R223R260R7R355R645R527R496 R61R913R253 R435R382R135R743R568R955 R67R464R773 R65R530R744R930R495R272R374R758R32R795R278R39R175R650R717R56 R746R492R55 R12R866R17R486R569R359 R863 R11 R573R960 R919R660R456R92R198 R109R847R322R596R603R961R33 R565R313R270R443R607R263R402 frei_A R230R886R167R193 R171R577R783 R60R444 R63R797R557R418R297R682R147R356 R586R410R84 R780 R740 PX54 R142 R251 R868R82R205R731R984R553R590R902R623R1000R143R749R122R325R27R244R639 R396 R810R985R822R638 PX46 PX2 R469 R327R970 R40 R127R542R307R203R484R173R80 R972R861R211R846R420R621 R352R745R909R332R481 R873R969 PX24 PX61 R769 R448R963R4R200 R154R31R204R49R187R468R658R904 R570R212R96 R16R980 R506R53R389R372R905R787 PX25PX53 R125 R661R725R326R397 R532 R48R202R115 R290R975R105R190R380R188R441 R304 PX39 PX44 PX27 R899R895 R353R201R555R855R208R90R350R572R951R782R324R21 R762R642R428R587R900R414R927 PX62 R302 R316PX52R379 R835R13R488 R876R436R564R709R933R368R688R636R711 R929R561R43 R317R490 R299R849R814 R197 PX34PX43 R41 R550 R644R831R894R794R2 R698R36R518R548R833R240R571R869 R46R98R562R225R764R694R271R578 R528 R100 R813 PX69 R620 R243R169R5R616R194R385R502R593R911 R103 R179 R373R713 R473R917 PX21 R938 PX48 R598R176PX45R690R604PX26R509R670 R280R138R417R181R666R69R474R282R298R877R477R702R551 R567R707R531R137 PX65 frei_BR558 R777R64R344R14R653 R237R915R475R778R879R217R289R793R288R704 R916R130R824R747R697 PX14R992 R634 R977 PX42 PX3R736R921R883R959R696R928R75R844R935R264R245R447R91R859 R409R433R207R800 PX33R896R391R178R74 R662 R541R334R466 R413PX66R338R340 R626R116R320R522R99R741R630R29R828R416 R719 R923R973 PX1 R979 R68R887 R537R739R9 R512R390R86 R247R821R808R574R922R415R629R248R189R942R536R369R908R817 R560R482 PX79 PX32 PX64R266R150R93R585R714R871R478R126R404R885R149R776R669R261R121R823R614R398R588R657R618R467R254R976 R70R611R491PX31 R146R331R159R305R281R220 R971R559 R549 R584 R675 R465 R330R665 R556R377 R798 R891R761R851R23R362R724R437 PX7 R829 PX30 PX55R432 R407R850 R426R367R931R898PX51R192 R257R703R15R563R801 R388 R236 R336 PX60 PX10 R450 R128R195R446R153 R932R720R139R228R196R66R160R422 R770 R789 R219R499 R242 PX11 R525 R544 R750R227R434R699 R335R508 R727 R301R818PX8PX12 R393R946R679 R186R323R815 R504R306R807R457R117R328 R427R312R106 R292 PX28 PX9 R174R918R882R342 R503R710R371 R722R989 R609 R291R748 R214 R78R874 R110R840 R920R514 R88R673 PX56 PX49R347 R246 R241R716R683 R766 R26R370R633 R199R995R206 R19 R786 R451R57R925R277R419 R701 R162 R599 R10 R375R606R386R685R774R315 R517R213 R987 R445 R759R308 R796R440 R95R767 PX4 R429R659 PX38 R997R842R262R640 R856R210 R461 PX13 R729 R38 R259R523 R285 R132 R145 R605 R910 R892 R163 R401 R691 R575 PX15R533R172 R934 R686 R637 R737 R706 PX22 R582 PX17 PX19 R319 PX5

R83 PX6 PX16 PX20 PX57 PX37 PX18

PX35 Ce — M­—M­— Research Report 2013 PX36 Science 20 21 Discussion on Art and Science You Really Call it DNA? A round table with Dorothee Golz, Peter Pakesch, Christoph Bock and Giulio Superti-Furga

Dorothee Golz, a sculptor and digital painter Golz: Yes. That is why I called the sculptures who also contributed to the CeMM Brain Lounge PX from the beginning, and numbered them approached Giulio Superti-Furga with the idea ­according to a certain system. For example, of studying part of her oeuvre using scientific PX1204: One thousand means first generation, ­methods. The goal was to map ­genealogical two hundred means the second branch of the ­relationships in the “PX” series of her ­sculptures family. Four means the fourth member of this and to discover connections that might not be second family. My thought was that nature readily apparent to the viewer or even to the is ­creative, and in a way, also artistic. When ­artist herself. Part of the analysis was ­performed ­thinking in terms of generations, the artistic by Christoph Bock, who is a Principal Investiga- ­process overlaps with natural processes. Nature tor at CeMM and works on the high-throughput doesn’t invent things all of a sudden either, but analysis of genomes and epigenomes. Peter always adds on, is evolutionary.­ Adds to some- Pakesch joined a discussion round at CeMM in thing that has ­developed, which has emerged spring 2014, which focused on the results of this from genetic variations and mutations. Nature collaboration between arts and sciences. He is uses these to develop new forms. In a sense, one of Austria’s most accomplished experts in ­evolution also has a language; perhaps life forms contemporary art, pioneer gallery owner, curator­ can also be compared to words. I tried to develop and director of the Universalmuseum Joanneum an artistic language with vocabulary. in Graz. Superti-Furga: Did creating generations Christoph Bock, Peter ­Pakesch, Golz: What was the aim of the project? I started ­motivate you and help in the creative act, Giulio Superti-­Furga and Dorothee Golz in CeMM�s Brain the PX project almost 25 years ago. At the time, or was it also a bit limiting? Did continuing Lounge I was interested in developing an artistic ­formal the ­generations feel like a chore, or was the vocabulary, and I asked myself how to go about it. ­presence of a vocabulary liberating? I started with a few basic objects, built them and then recombined the forms with one another. Golz: It was liberating. It gave me the feeling On the basis of the first generation of these that I have an incredible range of possibilities. objects I then developed a second generation And if I want to incorporate something new, of objects, which combined properties that had I can do that in the next generation, as a kind already appeared in the first generation. New of mutation. Recesses, structures, colors that character­istics, new features then began to arise, I haven’t used before, even dimensions in which and I subsequently carried these over into a I previously might not have worked. So in that third generation. respect I wasn’t limited at all. The established vocabulary helped me carry the project further. Superti-Furga: Did you have the concept For me, it served to remove the randomness from of ­generations in mind from the beginning? artistic creativity. I created a framework within which I could work, and upon which I could also orient myself.

Ce — M­—M­— Research Report 2013 Science 22 23 As an artist Superti-Furga: A creativity machine? Superti-Furga: That was Dorothee’s job? Superti-Furga: There are a number of approach- Pakesch: I can’t make any general statement es here. Essentially, it is an ­artistic undertaking, here. For me, great quality arises where there is works, there Golz: More like coordinates along which Bock: I asked Dorothee to define the main in which the artist tries to ­comprehend her own the greatest idiosyncrasy. This is a principle, are processes I could orient myself. characteristics and to categorize each object on work in its entirety by ­taking a super­ordinate the originality principle, which has sometimes of mutation, that basis, which resulted in an Excel spread- perspective. The description is more than been more and sometimes less pronounced in Superti-Furga: How did you think of asking sheet with 100 PX objects and 38 attributes for the sum of its parts, and new questions arise: the arts over the years. The natural sciences, if selection, CeMM for help? each single object. In doing so, she didn’t just ­whether the fathers, mothers, and ­children were I naively understand it correctly, aim for repro- recombination include actual physical features such as “large,” in the same place at the moment of creation, ducibility of results, that experiments must be and evolution Golz: I’ve always seen a scientific analogy in “­standing,” “cast in concrete,” in the catalog, but if there was cross-fertilization, etc. Dorothee’s repeatable, that processes must be computable. that take place. my work. So when we got to know each other, also non-material values such as irony, or how sculpture series is a straightforward story, While in the arts there is often a demand for the the idea of actually looking at it on a scientific important an object was to her personally or to but can this method of analysis be applied to unexpected, the original, the unique. Though basis emerged. I saw it as a consequence of my the series. We began the quantitative analysis other artwork, to music, to poetry? Could the that isn’t upheld overall, of course. I see a meth- work that through science I might confirm to using this table as a starting point. The first step ­Joanneum be represented in a network that has odological conflict there. some degree that the system I’ve developed was to translate it into a binary matrix. Each its own logic? And does the act of analyzing works. row is an object and each column is an attribute. demystify things, or does it give rise to entirely Superti-Furga: I have the feeling that’s a A black dot indicates the presence of the attribute new ­contexts or dimensions? myth. I see the scientists and the artists here Superti-Furga: What was it that you asked of in a multidimensional space within which the approach their work in a very similar way. The Christoph, and how did you both approach it? objects relate to one another. Bock: I think we need to make sure that we keep ­methodology is indeed different, but even among the art historians’ and the artist’s applications scientists it’s about who has the coolest new Golz: I showed Christoph the work, explained Superti-Furga: Dorothee, were you surprised of this methodology separate. In an art history idea. And that has to do with creativity. Couldn’t the system of designations to him, and asked him by anything you discovered? context, any reasonably coherent group of works one also argue the reverse, that if the genealogy to apply the laws or formulas used in biology to could be described and analytically mapped using of an idea can’t be traced, then it’s been ­falsified find or calculate genealogical relationships, in Golz: I was actually more surprised by how meaningful criteria identified by art historians. or perhaps doesn’t even exist? It can also be order to then render the whole thing in the form conclusive the representation is. I was somewhat But Dorothee’s intention was a different one: to liberating to say, as an artist or a scientist, I work of a diagram. At that point I didn’t know how amused to see that objects that are “ironic” are her, my methods were ultimately a means to an within a certain context. For example, in music. the diagram could or should look. Christoph was usually standing. There are hardly any ironic end, namely to create new art. To follow and to You often hear pieces or parts of song that are very open to this rather unusual, unconventional pieces among my hanging work. Based on the break with the results provided by the computer; completely referenced, and yet you don’t know subject matter that he now had to work with. diagram, I’ve discovered that other criteria are to become aware of certain implicit limits to how aware of this the artist was. Wouldn’t a The fact that these are art objects, and not... important, that aesthetics takes precedence over one’s own imagination, in order to overcome real genealogy be much more interesting here, originality. them. to know how connected the influences actually Superti-Furga: ...humans or life forms. are? We believe that we are free and can invent Superti-Furga: Peter, what are your first Golz: That’s quite insightful and true. No things without context. But at least since people Bock: As an artist works, there are processes­ ­associations regarding this science-art project? ­computer could calculate the objects or build like Marx explained it to us in the 19th century, of mutation, selection, recombination, and them the way I made them. Not even using the we know: “We are constantly in some sort of ­evolution that take place. This happens Pakesch: I find the approach fascinating and information it might gather through the analysis. ­context.” When I think of my own scientific ­continuously, but mostly unconsciously. The above all impressive. If you look at it from the The ingredients, the list of characteristics come oeuvre, it would certainly be very beneficial to significant new step we took in this project was perspective of art, though, one could also say from me, after all, I made them up. For me, the recognize the connections, to see where some- that we were looking for a way to visualize these “so?” There is this ambivalence that comes up genealogy is also a way to find out how the act thing new has really come up, and where this processes and to make them ­transparent by again and again in the history of art. Even in the of artistic creation works. How does it work new thing came from. I wouldn’t consider that ­analyzing them through quantitative ­methods. baroque period there was speculation as to the inside an artist? What processes take place there? to be ­restrictive, or counter to the creative act, but It is not enough, of course, to take pictures degree to which art is calculable. What fascinates rather as ­enlightening and interesting. of sculptures and to load the photos into a me is that the genealogy of patterns and textures ­computer. We aren’t at the point yet, and we could put us on track to analyze larger structures. might never be, where a computer can look In and of itself, that could already be an artistic at a picture and recognize its essential charac­ as well as a scientific principle. There is some- teristics. In principle, the essential properties thing really attractive about it, but at the same of these objects can be only be adequately time I see that the appeal or the quality of art lies ­identified by the artist herself. ­precisely in the fact that systems come up again and again, reappear, and yet art always manages to outsmart these systems.

Ce — M­—M­— Research Report 2013 Science 24 25 Pakesch: Perhaps we’ve misunderstood Golz: I didn’t apply the scientific analysis to Peter Pakesch Artistic Director, ­Universalmuseum Joanneum, Graz each other. These references exist, of course, my work as a whole. I used the PX series to Giulio Superti-Furga and we are talking about a system that is both develop a very individual formal language, Scientific ­Director, CeMM very large as well as very well defined. But it is which I then applied to other subjects. My basic Christoph Bock Principal Investigator, CeMM also the case that art operates within a state of motivation was, as an artist, to someday have Dorothee Golz Sculptor and strong ­ambivalence, in a state of ­contradiction, a signature style that I can use as a metaphor. Digital Painter ­constantly questioning this system and in part It’s not about taking things that exist ­one-to-one working against it. So it really is like being and ­recombining them, and thereby to perhaps within two systems. On the one hand, within create a kind of tableaux. I wanted to translate this large referential landscape, while on the the language of things, of the physical world that other hand art – at least in our Western notion ­surrounds us, into a very personal, ­subjective, of art – is expected to exhibit this very, very individual language. I started with five basic ­massive sign of individuality. It must live up to forms, then expanded on them with new the maxim that, in Western art, the individual ­features, new characteristics. The properties and ­individual thought are considered to be weren’t pulled out of thin air, they weren’t things very important. And this is a source of constant that I just suddenly thought up. I took ­utilitarian ­friction. For me, that is also a part of the inherent objects, objects with which we humans surround­ energy that results. So art very much depends ourselves, that were created by us humans, upon ­operating within these contradictions. and looked at them closely. I stripped them of At the same time, it also makes the claim of ­everything that they need to fulfill their function representing something universal. I simply see and then looked at what was left. If you leave a the advantages in an extremely high degree of humidifier with only those characteristics that heterogeneity, both in the methodology and the aren’t necessary for it to function, you are left results, which have been very strongly cultivated with just a color, a basic form, and a volume. in the outgoing 20th century and beginning of A formal language is left behind, angular, soft, the 21st century. Unlike in other periods, where geometric, or biomorphic. I distilled these words a much stronger mainstream was developed. out of utilitarian objects created by human beings and reapplied them to art objects, which have no Superti-Furga: This brings to mind fashion; functional significance. one could probably apply this methodology very nicely to fashion. Superti-Furga: Is there a future for the PX series? If so, to what extent will it be influenced Pakesch: I like the idea to not reproduce by this scientific analysis? ­creative-thinking processes, but rather to work with them. Conventional art history is to some Golz: I find that an incredibly interesting degree utterly overwhelmed in this regard thing to explore. Christoph has given me a and just trying to keep up. Artistically and table of a thousand possible PX objects. The ­scientifically, it is also important to keep these computer specifies what each object would somewhat separate. I would be interested to look like. The description might be “medium see this mirrored in the work of other artists, size, flat, blue, made of plaster.” I would like to or applied to fashion and or creative products. give this ­description to three or four different I wonder: To what extent is the sum of an ­people. Once I would make one object from this ­individual’s thoughts embedded in a context? ­description, once another artist, once a skilled To what degree is there a matrix in place that craftsman who can imagine and build something I can comprehend? But I also know plenty of according to this description. And maybe also examples of artists who have managed to break a person who has seen my objects, isn’t an artist through their own matrix. Take the artist Picabia, herself, but who would try to feel what matters for example. He was very good at knowing how to me as an artist. I would look at how similar to break repeatedly with his own matrix, so that or how different these objects are. And analyze his work is not readable as an oeuvre. This is also why they are similar or why they are different. a huge issue, right up to Kabakov and ­others, Where am I necessary as an artist? where an artist has deliberately introduced multiple­ personalities.

Ce — M­—M­— Research Report 2013 Science 26 27 Bock: One possible outcome might be that the Pakesch: But with the limitation that it is my Superti-Furga: I can very well imagine that lay person or the craftsman produces something map. Mapping has been very popular for a long there are considerable variations. There are artists plausible, at which point one could say that time; it’s been used to investigate influences. who use a very broad language, and then there the story of the PX objects has achieved such There is general agreement that first comes are those who use a much narrower language. momentum or inherent qualities that it has ­Cubism and then abstract painting; that is, That might be something that is visible in the started to emancipate itself from the artist. Or it that developments have certain references. But work’s DNA. could be that this experiment might end up as a ­usually it’s most interesting when the mapping failure, which would suggest that this structure, is subjective; it no longer has the same degree of Bock: I think that the concept of DNA is helpful these objects, and this story have no life of their validity, but it is very productive. That’s why it as a metaphor. In biology, there is the principle of own beyond that supplied by the creating artist. would be a worthwhile thought experiment to separation of genotype and phenotype. We have apply such a method to various works, including developed methods through which we can take Pakesch: There are artists who constantly intellectual history. How do the collected works the phenotypes that we see today and, using a reinvent themselves. But there are also artists from the life of a particular philosopher look like? genealogical analysis, can reconstruct how they who create instructions and scenarios for action, How much did the work evolve, where are there evolved into that. In biology, just as in the arts, which they then pass on to others and thereby breaks or continuities? there are jumps that can be difficult to explain. are able to achieve certain qualities; who rather In biology, we are increasingly capable of dealing consciously bring their art into the realm of the Bock: Our analytical method isn’t an attempt at with a chaotic element and an element that wants robotic, of the absolutely reproducible. But this objectivity either; there is, after all, still the step to evade predictability. is always just a part of a patchwork, an overall in which an artist or an art historian categorizes ­system in which the one can’t live without the a group of works. This step remains a subjective Pakesch: Yet the question that science doesn’t other. In today’s art world, I need extremely and often an intuitive one. The advantage of our really ask itself is whether that will make it individualistic-romantic art just as much as very analysis in comparison to the existing forms of ­possible to produce art robotically. That’s all good calculated, very conceptual art, because one mapping is that we insulate the ­categorization and well, but for me it raises the question: what’s doesn’t work without the other. And that might from the mapping, such that three, ten, a the point? distinguish the system of art from that of actual ­hundred people, perhaps even the original artist nature. and art historian, can categorize the same group Superti-Furga: Are the maps that one creates­ of work and create maps that can be directly always so trivializing? Or do they have their Superti-Furga: You are interested in neuro­ ­compared. The categorization by the artist might own soul, and one can recognize patterns biology. Suppose we were able to have a record look very different from that of the art historian. and ­regularities that have an even deeper of everything that a person thinks in their life, ­meaning than the artists, architects, or fashion and could rewind to the moment when artist X Pakesch: I would like to come back to a question ­designers intended? Are there any secrets or got the idea to depict something entirely new. for the scientist: Does the analysis, the mapping, big ­questions that might be unraveled through They, the artist, will inevitably – but that’s an reveal anything like a DNA? Are there serious such a ­genealogy? Do we recognize flashes of ­interesting debate itself – have taken inspiration parallels to the material with which you usually ­inspiration that we might not have identified from their environment, because they know work? as such without a map? no other formal language. They couldn’t talk before language existed. They couldn’t draw Bock: I think yes, the concept of ­mutation and Pakesch: I rather think that the genealogy is an before ­seeing forms. So if you were to take the selection, the double step between generating­ added tool for tracing one’s own creative process whole Joanneum, the whole Kunsthalle, and all and selecting what will go into the next and for making that process itself a subject. the modern work, and if you were really able to ­generation. I think this concept underlies all map these connections, don’t you think that in ­artistic production. If you look at a very ­complex Golz: Christoph said earlier that, on the one a temporal, as well as artistic, scientific, literary piece of art that has been developed over the hand, this genealogical method can be applied dimension one would recognize networks that course of years, it’s only the final product that in an art historical sense to understand retro­ in some way are no different than what Dorothee ends up in the museum. In some cases, we spectively what happened. In the sense of my and Christoph have done? are lucky to have some preliminary versions project, I was just aware that creativity and ­surviving. If we had all the drafts, and maybe evolution are related. Even an artist’s personal even a map of the artist’s brain, then we could generation of ideas has a history. It develops and basically show this process of mutation and develops from an initially manageable ­number selection, and the genesis of the artwork, in of basic ideas and then grows increasingly ­every work of art. In Dorothee’s PX pieces, complex as these ideas are combined with one we are fortunate that the various steps and the another, because these ideas also serve to inspire moment of their occurrence are preserved as and ­create new ideas. artifacts. With quantitative methods we can gain a bit of an insight into the synthesis of art as a Superti-Furga: Thank you all for the interesting process of mutation and selection. conversation.

Ce — M­—M­— Research Report 2013 Science 28 29 Science at CeMM

+ Cancer + Infectious Diseases + Immune Disorders and Inflammatory Diseases + Post-Genomic Technologies + Diagnostics and Therapeutics Cancer ­A Battle Won in 2013 2013 saw a significant advance against myelofibrosis, and the overall number of MPN ­myeloproliferative neoplasms (MPN) in the patients in the EU is estimated to be around laboratory of Robert Kralovics at CeMM, in 300,000. The genetic cause for CML was collaboration with the group headed by Heinz ­identified over thirty years ago as the protein Understand Cancer and Taming it Reducing the Impact of Cancer by Changing­ ­ Gisslinger at the Medical University of Vienna. translocation BCR-ABL, which led to the Cancer has long been recognised as a major cause Policies and with Smarter Research­ MPN is a group of blood disorders characterized ­development of drugs that have dramatically of death, particularly in ­Western ­populations Unfortunately, the effect of all this research on by the inappropriate growth of one or more of improved long-term survival rates. In contrast, although this is now spreading throughout the ­reducing total cancer deaths has not yet been fully the myeloid blood cell lineages. MPN includes ­identifying the genetic cause of some of the ­developing world. From the so-called “war on realized and there is still a lot of work to do. ­Global chronic myeloid leukemia (CML), polycythemia other major MPNs has lagged far behind. ­cancer”, which was launched by then President of cancer cases have recently reached 14 million, ­leading vera, essential thrombocythemia, and primary the United States, Richard­ Nixon we have come a the WHO to claim that we are ­facing an impending long way. Cancer is not just an enemy, a foreigner. “tidal wave” of cancer. Preventing­ cancer should It is more an ­unwanted state of internal affairs. remain a top priority­ for policy-makers, and banning Fig. 1 Frequency of CALR A new ­perspective may help us develop new ideas smoking in all workplaces, ­restaurants and bars, PV ET PMF Mutations in ­Myeloid on how to come to grip with it. with no ­exceptions, in countries like Austria and Neoplasms: pie charts China, as has been done successfully in many other show the distribution of JAK2, MPL, and CALR A lot has happened in the last forty years, ­particularly countries, would go a long way to reducing ­cancer ­mutations in the three from the ­beginning of this century when the human ­incidence. ­classical ­myeloproliferative ­neoplasms. The bar graph genome was sequenced. Cancer is essentially­ a shows frequency of CALR genetic disease being caused by ­alterations in the In the laboratory, there are many battles being mutations in myeloid DNA sequence of certain genes, which leads to the fought, and notable successes are leading to ­victories ­cancers with total ­numbers of ­patients analysed for a ­transformation of a normal cell into a fast grow- in the clinic, which is also helping to reduce the specific disease ­entity. The ing and invasive ­cancer cell. ­Having at hand the impact of ­cancer. At CeMM, there is a huge drive n = 382 n = 311 n = 203 matrix underneath visualizes the distribution of ­mutations full sequence of all the genes in the human body towards understanding the biology of cancer and in JAK2, MPL, CALR, and has empowered researchers to uncover more of developing more effective treatments. In 2013, one SF3B1 among patients with JAK2 mutant MPL mutant CALR mutant JAK2, MPL, CALR wild type the molecular ­complexity under­ ­lying this highly significant battle was won against ­myeloproliferative refractory anemia with ring sideroblasts ­associated with ­heterogeneous ­disease. Once the genetic cause of neoplasms in the group of ­Robert Kralovics at marked ­thrombocytosis a cancer type has been identified, in ­principle specific CeMM. In the laboratories of Denise ­Barlow, (RARS-T). AML: acute ­myeloid drugs can be designed to target it and hopefully ­Christoph Bock, Stefan Kubicek, Joanna Loizou, 100 ­leukemia, CML: chronic ­myeloid leukemia, CMML: cure the disease. But the rapidly growing ­knowledge and Giulio ­Superti-Furga there is a strong focus on chronic ­myelo-monocytic allows ­researchers to also find new­vulnerabilities ­understanding the biological basis of cancers such as 80 ­leukemia, MDS: myelodys- plastic syndrome. of cancer cells, such as ­particular ­metabolic leukemia, as well as on the role of epigenetics,­ which Adapted from Klampfl ­idiosyncracies or dependency­ on a specific cellular is a relatively recent ­phenomenon and could lead to 60 et al, New England Journal process, such as protein ­folding. a new ­generation of treatments. Finally, scientists of Medicine, 2013. at CeMM, ­particularly in the ­laboratories of Sebstian 40 ­ ­Nijman, ­Stefan Kubicek and Giulio ­Superti-Furga are using ­different approaches to identify new drug 20

­targets for cancers including lung cancer. ­Together (%) frequency CALR mutation these efforts should provide new ­paradigms in the 0 process of tweaking cancer cells into a harmless state. PV ET PMF dnAML CML MDS CMML RARS-T healthy n=382 n=311 n=203 n=254 n=45 n=73 n=64 n=24 n=524

JAK2

MPL

CALR

SF3B1

Science 32 33 Kralovics and Colleagues: Epigenetics and Cancer Myeloproliferative Neoplasms

Others at CeMM have been working on alter- study of imprinted genes has uncovered many native approaches for tackling many ­different unexpected findings about what controls the In 2005, CeMM’s Robert Kralovics was then They used a technique called whole exome cancers, including leukemia, breast and lung on/off state of a gene, which are likely to be working at the University Hospital Basel in sequencing at the Biomedical Sequencing cancer. A relatively new phenomenon that has ­relevant for understanding how epigenetics ­Switzerland. Along with Radek Skoda and ­Facility, which was set up by CeMM and the entered the cancer arena is epigenetics, which plays a role in cancer. PhD student Aleksandra ­colleagues, and a team headed by Mario Cazzola Medical University of Vienna and is run by is defined as heritable changes in gene activity Kornienko is using a recently developed RNA at the University of Pavia Medical School in Italy, CeMM PI Christoph Bock. By sequencing six that are not encoded in the DNA (in contrast sequencing pipeline to identify a set of lncRNAs he made a significant breakthrough by ­identifying patients with primary myelofibrosis who did to ­genetics). Global epigenetic changes, such as expressed in normal human granulocytes, which a gain-of-function mutation in the gene called not have a JAK2 mutation they found a second DNA methylation, are now recognised as one of will later be used to screen haematological malig- JAK2 in around 75% of patients with MPN. This common mutation in the gene encoding for the classic hallmarks of cancer, along with such nancies for possible biomarkers, in collaboration eminent discovery led to the development of Calreticulin. The high frequency of this ­mutation well-established characteristics as ­immortality with Robert Kralovics’ group. JAK2 inhibitors, which have now been ­clinically was then discovered upon sequencing the gene and uninhibited growth. Scientists are slowly approved. Their success drove the search for in a further 1107 MPN patients. This work was beginning to understand that deregulated In a landmark paper published in the journal ­other common mutations in the remaining published in the prestigious New England ­epigenetic mechanisms play a significant role in ­Science in 2012, the Barlow laboratory dis­­covered patients, which, in 2013, led Robert and his ­Journal of Medicine (Klampfl et al., 2013). Exactly causing many different cancers. New discoveries that a special class of lncRNA is able to silence PhD student Thorsten Klampfl, along with how this mutation causes MPNs awaits further in this field may make important gains in the war imprinted genes by the act of their ­transcription Mario and a new team to ­victory number two. work, but the discovery itself is a significant win on cancer, as they could lead to the development (Latos et al., 2012). Following on from this work, for scientists as it contributes to a much better of urgently needed and more effective anti-cancer PhD student Federica Santoro and Post-doc understanding of disease pathogenesis, and treatments. ­Florian Pauler, along with others in the Barlow as such will lead to improved diagnosis and group, developed a system that ­enabled them disease­ management. Denise Barlow’s group has been working for to turn off the expression of a ­specific lncRNA, many years on the mechanisms of ­epigenetic Airn, at different times during the ­differentiation regulation. More recently they have been of mouse embryonic stem cells. Using this ­focusing on understanding how long non-coding ­system, and supporting their previous results, RNAs (lncRNA for short) silence or switch off they found that Airn lncRNA expression is Towards Personalising Cancer Therapy imprinted genes, which have one copy silenced both necessary and sufficient to silence the in a parent-specific manner. Genomic imprinting ­overlapping Igf2r gene. This important work is a classic example of epigenetics, and the was published in the journal Development (­Santoro et al., 2013). Christoph Bock’s group at CeMM is utilizing These data are then used to dissect­ the interplay the hematopoietic system and the ­development between epigenetics, genetics and transcriptional of leukemia to study the role of epigenetic elements by exploiting ­bioinformatics algorithms ­modifications, particularly DNA methylation, that the group have developed. This work will with a view to improving patients diagnosis give rise to a dynamic and potentially predictive and treatment. The team combines ­biochemical computational model of the deregulation of cell Detecting Histone Modifications assays with next generation sequencing to states in leukemia, which will help to predict map the dynamic epigenetic changes that personalised therapies for any given individual occur throughout the genome during cell cancer patient. While aberrant DNA methylation patterns have In the context of the Christian ­Doppler ­differentiation and cancer progression. long been associated with cancer, ­mutations ­Laboratory for Chemical Epigenetics and amplifications of histone modifying and ­Antiinfectives, researchers in Stefan enzymes have only recently been detected in Kubicek’s group at CeMM have been devel- cancer cell lines and primary tumour ­material. oping fast, robust assays to quantify all In some cases, these genetic aberrations result histone ­modifi­ca­tions in cancer cell lines and in altered ­histone modification levels. For ­primary tissues.­ Using a ­panel of 104 differ- example, ­activating mutations in the histone ently modified ­synthetic ­histone peptides methyl­transferase EZH2 have been detected in they have already ­extensively characterized ­diffuse large B cell lymphomas. The subsequent the binding ­specificities of 132 monoclonal increase in enzymatic activity results in a global antibodies ­directed against ­different histone increase in the levels of histone H3 lysine 27 ­modifications, of which 33 were found to be ­trimethylation, which is thought to promote highly ­specific. These ­important tools will tumourigenesis. In 2013, the first small molecule allow them to ­quantify changes in ­specific inhibitors of EZH2 have entered clinical trials in histone ­modifications and study their role in patients with B cell lymphomas and advanced cancer initiation­ and ­progression, which could solid tumours. ­ultimately lead to the development of ­valuable diagnostic tools.

Ce — M­—M­— Research Report 2013 Science 34 35 Cancer and DNA Damage Innovating Anti-Cancer Therapeutics

In addition to deregulated epigenetic mecha- and its ­ability to activate a downstream signaling Once the genetic or epigenetic abnormalities that may be useful for treating patients with nisms, another important cause of cancer­ is the network is essential for maintaining genomic that cause cancer have been discovered, targeted a specific and common set of genetic mutations. failure to repair damaged DNA. This can occur integrity, ­protecting against the development ­therapies can be developed to exploit them. Lung cancer is the leading cause of global cancer when specific DNA repair proteins are mutated, of cancer. A handful of these are now available in the deaths, therefore there is an urgent need for rendering them non-functional. Joanna Loizou’s clinic, and many result in dramatic ­therapeutic new and more effective treatments. group at CeMM is building an understanding Mutations in ATM also lead to an inability to responses, substantially extending patient of the mechanisms and pathways that repair repair DNA breaks that occur in a programmed ­survival. However, many abnormalities cannot Together with the teams around Jacques DNA damage generated by replicative stress manner during the development of B and T cells, be ­targeted with small molecule inhibitors, and ­Colinge and Keiryn Bennett, scientists in the and in a programmed manner in B and T cells. which are important cells of the immune system. other approaches are needed. In addition, even laboratory of CeMM’s scientific director Giulio This should help them to find out how this Indeed, patients carrying functionally inactive with the successful drugs cancers are fighting ­Superti-Furga have over the years become might go awry and lead to cancer development. ATM are immunocompromised. The group has back by developing resistance, which has become ­proficient at the ­identification of the target shown that for ATM to carry out its function the next big battle. Several groups at CeMM proteins actually engaged by drugs (see also The group has recently discovered that an in the resolution of programmed DNA breaks are ­looking to boost the development of more Diagnostics and Therapeutics). This strategy, ­important DNA damage kinase, known as it requires two co-factors, ATMIN and NBS1. ­effective anti-cancer drugs and overcome the rather than starting from a defined genetic lesion ATM, is activated upon DNA replication stress. Loss of these two co-factors, or of ATM itself, challenge of drug resistance. and then look for a matching chemical agent, Using a technique that allows for a global leads to an inability to form normal, functional reverses the process and uses the ­chemical ­snapshot of ATM targets they have shown that T cells. Hence, development of a functional Scientists in Sebastian Nijman’s group have been agents to go fishing. This “follow the drug” it ­phosphorylates over 250 proteins upon DNA immune ­system requires a functional DNA creating alternative, so-called isogenic models of approach has shown that many therapeutic replication damage. The activity of this kinase damage­ response. cancer cells by engineering them to carry defined agents ­exercise their effects on multiple protein mutations. These isogenic cancer cells are being targets, often spread across different cellular used in genetic and chemical screens to identify processes within the interlinked molecular so-called synthetic lethal interactions. These ­network that forms the inner workings of cancer Fig. 2 Target-Disease Net- A B work Model (A) ­Schematic interactions can be exploited for treating specific cells. At CeMM, this knowledge is accrued to representation of a ­diffusion T cancer subtypes carrying genetic abnormalities identify new ­possibilities to employ single drugs 14 T 16 Drug treatment process in a “toy” network,­ network that cannot themselves be directly targeted with or ­combination of drugs. Also, it was used to proteins displayed as 15 13 18 model nodes, labelled 1 to 12. 17 inhibitors. They have recently developed an ­predict the efficacy of therapies in cellular models Proteins are drug targets and T isogenic model for one of the most common and of leukemia (Rix et al., Plos One 2013). assigned­ with probabilities S 12 deadly lung cancer subtypes. This led them to the (black = maximum, white = 11 minimum) so that proteins identification of a clinically approved compound residing close to targets S S 10 5 Drug receive higher probabilities and synergistic effects are 8 S ­obtained for proteins close to 7 6 1 several targets (“S”) or linked in multiple ways to a single 2 target (“T”). (B) Scoring 9 4 Disease principle illustrated in a part network of the actual network (grey): Computation model two diffusion processes of a correlations core performed separately on the 3 network yield a model of the drug treatment effect (red) and of disease ­influence on the network (green). ­Combination of these two sets of scores allows for computation of a correlation­ score (blue) ­measuring ­adequacy of a drug treatment.­ Adapted from Rix et al., PLoS ONE 2013.

Ce — M­—M­— Research Report 2013 Science 36 37 How to Beat Infections: New Lessons Infectious Learnt from Our Own Immune Systems

Finding new ways to treat infectious diseases The multidisciplinary team investigated exactly isn’t easy, but one powerful approach is to learn how RNA is recognised by the IFIT proteins by Diseases­ from the experts. Our immune systems have protein crystallography. The crystal structures evolved over millions of years into complex revealed a new helical domain in the IFIT protein machines that work to eradicate many different that houses a positively charged cavity designed types of infections. By studying the molecular to specifically engage only single stranded viral and cellular details of the immune response RNA bearing a 5’ triphosphate group. This to infectious diseases, scientists at CeMM are explains at the molecular level how IFIT proteins Getting Ahead of Pathogens Vaccinations have also proven to be invaluable ­hoping to open up new therapeutic avenues. capture only foreign viral RNA, and how they Infectious diseases, those caused by ­pathogenic for preventing infectious diseases, with the most distinguish it from host RNA molecules. This ­bacteria, viruses, fungi and parasites, and transmitted­ ­notable success against smallpox, which was declared One successful project, published in 2013, mode of action sets the IFIT proteins apart from between humans, have had a dramatic influence on ­completely eradicated in 1979. Vaccines have also focused on IFIT antiviral proteins, which act the other known canonical cytosolic sensors of all of our lives. They spectacularly altered human almost eradicated polio, which is another ­devastating as foot soldiers to guard the body against viral double-stranded viral RNA, RIG-I/DDX58. history, for example by wiping out 3-5% of the world infectious disease. In 2013, only 400 global cases ­infections such as those caused by influenza­ population in the 1918 flu pandemic, shaped human were reported, which were limited to a handful of and vesicular stomatitis virus. In 2011, Additional biochemical and functional assays evolution by driving the development of an entirely ­countries. Disinfectant and antiseptic procedures Andreas ­Pichlmair and colleagues in Giulio further demonstrated the mechanism by which new type of immune system (adaptive immunity), have also played a substantial role in reducing the ­Superti-Furga’s ­laboratory at CeMM discovered IFIT proteins selectively recognize viral RNA and and their interminable presence influences our every- incidence of infectious diseases that were once rife, that IFIT ­proteins unexpectedly interact directly thus how they block viral infections. This work day activities, mostly without us realising it (you did particularly in hospitals and other clinical settings. with viral ribonucleic acid (RNA) and inhibit validates new paradigms for how this family of remember to wash your hands today didn’t you?). its replication, thereby stopping the infection. proteins protects us against viral pathogens, and Even with these precious tools, we will never Now, following on from this, scientists in the was published in the prestigious journal Nature There are hundreds of different types of infectious ­completely eradicate infectious diseases. ­However, ­Superti-Furga group along with a team led by (Abbas et al., 2013). It also makes a promising diseases, ranging from relatively minor infections staying one step ahead of the bugs is critical, Bhushan Nagar, a professor at McGill University step towards the development of new drugs for such as the common cold, to more life-threatening ­particularly if we are to avoid another pandemic of Faculty of ­Medicine in Canada, have together combatting a wide range of virus-borne immune diseases like polio and tuberculosis. New infectious potentially epic proportions. At CeMM, several groups discovered the molecular blueprint of the IFIT system disorders. diseases are continually emerging as pathogens jump have recently made significant discoveries that are protein. species barriers and/or quickly evolve to become helping us get ahead of infectious diseases. Sylvia more virulent. Knapp and her group are now one step ahead of the bug that causes bacterial pneumonia by ­discovering Fortunately we have several powerful tools for how cells of the immune system help to fight the preventing and treating at least some infectious infection. Scientists in Giulio Superti-Furga’s group, ­diseases. Antibiotics, which were first ­discovered in collaboration with Bhushan Nagar and his group at ­accidentally by Alexander Fleming in 1928, trans- McGill University in Canada, have recently discovered­ formed medicine by curing patients with both how the body’s immune system recognises a group minor and life-threatening bacterial infections. of disease-causing viruses, and Andreas Bergthaler However, irresponsible use has led to the emergence and his team have uncovered a novel mechanism for of ­antibiotic resistant bacteria, and there is now an how liver cells are protected from oxidative damage urgent need to develop alternatives. caused by viral hepatitis.

Science 38 39 Learning From the Immune Towards a New Therapy for Sepsis Response to Lung Infections

In a third project, which was also published in several ­cellular functions that are managed 2013, scientists in Sylvia Knapp’s laboratory by ­regulating the actin cytoskeleton. They Elsewhere at CeMM, Sylvia Knapp’s group has In a related study in the Knapp group, a project discovered a critical modulator of the innate now show that WAVE-1 plays a crucial role been focusing on Streptococcus pneumoniae­ led by Post-doc Omar Sharif sought to elucidate immune response to bacterial peritonitis, also in macrophages as it mediates anti-­ (pneumococcus), which is the most prevalent the potential role of the cell surface receptor, ­another potentially deadly disease caused by phagocytic effects induced by lipid-derived ­respiratory pathogen and one of the most CD36, in pneumococcal pneumonia. CD36 binds infection of the peritoneum by different types of ­danger ­molecules in Gram-negative sepsis. ­common causes of community-acquired to a wide range of extracellular ligands, which bacteria. This project, led by PhD student Ulrich Their ­discovery, which was published in pneumonia and bacterial meningitis, both of enables it to function in a variety of cellular Matt, uncovered an unanticipated role for the The Journal of Clinical Investigation (Matt which can be deadly diseases. This bacterium processes ranging from angiogenesis to sensory protein WAVE-1 in the innate immune response et al., 2013), ­presents WAVE-1 as an important is particularly dangerous for children and elderly perception. It is also found on the surface of to this infectious disease. Previously, WAVE-1 new ­therapeutic target for developing drugs to people. Once it infects the body, the immune macro­phages and is known to help fight infection was only known as a protein that ­regulates treat severe bacterial infections and sepsis, for system responds by launching a powerful by the bacterium Staphylococcus aureus. another protein complex, Arp2/3, which has which there is currently no effective therapy. ­pro-inflammatory response to destroy it. This is followed by an anti-inflammatory The group now shows that CD36 is also response, which acts to limit tissue damage. expressed on alveolar macrophages and respira- These ­responses are predominantly effected by tory ­epithelial cells, placing it in the right loca- innate immune cells, particularly macrophages, tion to also tackle respiratory pathogens such which are found in the infected lungs. as S. pneumonia . To test this directly, they used How the Liver Deals with Infections mice lacking CD36, and found that it indeed plays In the Knapp laboratory, PhD student Joanna a role in S. pneumonia infection by ­influencing Warszawska and her colleagues discovered both the early innate immune response and that lung macrophages must be re-activated ­bacterial clearance from the lungs. These data Persistent viral infections with hepatitis B and In another project, in collaboration with in order for the host to successfully eliminate were published in The Journal of Immunology hepatitis C affect more than 500 million people. Keiryn Bennett’s group at CeMM, the ­Bergthaler a ­pneumococcal infection. They identified a (Sharif et al., 2013), and provide an important However, treatment options are limited due group has been studying global protein and key player, the protein LCN2, which keeps new look into the immune response to bacterial in part to the complex pathogenesis of these RNA perturbations in the liver upon viral macrophage deactivated via IL-10 induction­ pneumonia. This could help in the search for infectious diseases as well as a lack of suitable infection. By employing quantitative protein in the respiratory tract. While this helps new therapies to tackle the recent emergence tools with which to study them in detail in mass-­spectrometry as well as transcriptional­ ­prevent unnecessary inflammation in healthy of virulent serotypes that are resistant to current the laboratory. At CeMM, Andreas Bergthaler profiling by RNAseq, they were able to ­capture lungs, this protein – that can be further treatments. and his group employ a model approach by the dynamics of the liver proteome and induced by ­glucocorticoids – also prevents ­exploiting a tiny mouse virus called lymphocytic ­transcriptome over 100 days of persistent viral the required ­activation of lung macrophages ­choriomeningitis virus (LCMV), which shares infection. This provides a map, in ­unprecedented upon ­pneumococcal infection. The work was hallmark ­features with human viral hepatitis detail, of how the liver reacts to viral ­infection. published­ in The Journal of Clinical ­Investigation but allows them to study it far more easily. It has led them to poorly understood areas (Warszawska et al., 2013). These results are the of metabolism, pathogen-inflicted cellular first to describe a role for inactivated macro­ The team recently uncovered a novel mechanism stress, and inflammation, which appear to be phages in the progression of an infectious for how the host protects liver cells from virus- ­interconnected. To gain further insights into ­disease, along with the molecular mechanism induced oxidative damage. They used an array these host-virus interactions they are currently involved, and are likely to be important when of genetic and pharmacological tools to identify collaborating with basic scientists as well as treating patients with serious lung infections and delineate the molecular players and signaling ­clinicians with their invaluable perspectives caused by S. pneumoniae. pathways involved. Their results reveal potential from the bedside. new targets to improve the treatment of hepatitis patients.

Fig. 3 Lipocalin 2 (LCN2) A B is detrimental during pneumococcal ­pneumonia in mice and humans: 100 50 WT survivors (A) Survival comparison Lcn2 -/- of wildtype (WT) and 80 40 non-survivors Lcn2-knockout (Lcn2-/-) mice upon infection with 60 30 S. pneumonia. (B) Levels of LCN2 in bronchoalveolar 40 20 lavage (BAL) of intensive n=6 n=16 Percent survival Percent

care unit (ICU) patients BALF µg/ml LCN2 with bacterial pneumonia, 20 10 n=7 caused by Gram-positive or n=14 Gram-negative pathogen. 0 0 Adapted from Warszawska­ 0 50 100 150 200 Gram-pos Gram-neg et al., The Journal of ­Clinical Investigation 2013. hours after infection

Ce — M­—M­— Research Report 2013 Science 40 41 The Causes of Immune Immune System Malfunction­

Primary immunodeficiency disorders are Further analyses revealed that the protein a rare group of childhood diseases that are product­ of PRKCD was absent in the patient’s Disorders­ and ­characterised by an increased predisposition to B cells, as was the activation of known down- infection. They are caused by the inheritance­ stream effectors. These events are likely to of specific genetic mutations that impair the have caused the malfunction in B lymphocytes immune system and lead to a defective infection- and the ­development of autoimmunity. This fighting capacity, and are often associated with important discovery of a new genetic mutation other ­characteristics such as autoimmunity. that can cause human immunodeficiency was Inflammatory Indeed, severe autoimmunity in childhood can published in the journal Blood (Salzer et al., 2013). indicate a primary immunodeficiency disorder. It significantly enhances our understanding of Knowledge of the underlying mechanisms, B cell function, and could help in the diagnosis which are currently mostly unclear, could and development of treatments for patients with lead to the development of much needed related autoimmune disorders. Diseases­ new therapies. Kaan Boztug’s group analyses patients with immuno­deficiency disorders using In a related project on B cell deficiency and state-of-the-art genomic approaches available ­autoimmunity, also led by Elisabeth Salzer in at CeMM including exome sequencing. This Kaan’s group and in collaboration with research- enables them to identify the causative genetic ers from Ankara University, Turkey, the Center mutations, which they then use to analyse their of Chronic Immunodeficiency, Freiburg, The Protective and Destructive The immune system is also immensely powerful molecular functions and dissect the underlying ­Germany and the Medical University of Vienna, Properties of the Immune System because it needs to be able to destroy ­infectious mechanisms­ involved. and using similar sequencing techniques, the The human immune system is a specialized internal pathogens and cancer cells, and neutralise toxic team ­identified a homozygous mutation in the defence system. It is highly complex, consisting of agents. In addition, the inflammatory immune In 2013, PhD student Elisabeth Salzer and her IL-21 gene, which is a well known regulator­ of many different types of cells and molecules, such response, which can be triggered by tissue ­damage, colleagues in the Boztug group, in collaboration ­different parts of the immune response. Their as macrophages, white blood cells, antibodies and is strong enough to cause us to experience ­localised with the University Department of Paediatrics novel discovery that this mutation causes cytokines, which are all activated in different ways pain, redness and swelling. Its main purpose is to and Adolescent Medicine, discovered a new early onset inflammatory bowel disease and and under specific disease-causing conditions. respond to the trigger of ­inflammation and resolve molecular cause for a primary immunodeficiency is ­associated with defects in B cell numbers Some parts of our immune system act as a first line it. To keep this powerful system under control in a 12-year-old patient who was suffering from and function has important implications­ for defence and become activated by an initial infection and ­functioning well there are a large number of autoimmunity and immune dysfunction. They IL-21-inhibitor treatment strategies­ that have or by tissue damage, whereas others act in chronic ­regulatory mechanisms in place. This is critical also identified abnormal numbers of specific subsets been proposed for ­autoimmune diseases. disease settings. There is also a dedicated division because continuous stimulation of this part of the of B cells, which produce antibodies. To pinpoint for ­remembering a certain infectious agent and immune system can cause chronic inflammation,­ the genetic mutation causing the disease the ­preventing reinfection. which can lead to severe conditions such as team undertook single nucleotide polymorphism­ ­atherosclerosis. Atherosclerosis is a chronic disease array-based homozygosity mapping and exome Without our immune systems we simply wouldn’t characterized by damage of blood ­vessel walls, and sequencing on DNA from the patient and survive. When we do expose ourselves to damaging is a major cause of heart attack and stroke. Christoph ­compared it to that of close family members and agents or infectious diseases, which happens on a Binder and his team at CeMM have been ­investigating healthy individuals. This revealed candidate daily basis and mostly without us realising it, our the role of the ­inflammatory immune response in causative mutations in two genes. One of these immune systems are immediately activated and work driving the progression of ­atherosclerosis, and how genes, PRKCD, was known to play a role in B cell hard trying to restore us to a healthy state. How other components of our immune system, specifically signalling making it the prime candidate as the our immune systems function can tell us a lot about so-called natural ­antibodies, work to prevent it. disease-causing gene in this patient. how to fight diseases such as cancer and infections, and can be studied in patients with immune system ­disorders. At CeMM, Kaan Boztug and his group have been studying the genetic mutations underlying immune deficiency disorders in order to tease apart the molecular mechanisms involved and find new ways of treating patients.

Science 42 43 Fig. 4 Cartoon outlining How a Protective Immune Response Sterile inflammation protective properties of Atherosclerosis Infection natural antibodies (NAbs) Autoimmunity Sepsis, etc. specific to oxidation-­ Can Lead to a Deadly Disease Lupus, etc. specific epitopes (OSEs). NAbs exhibit housekeeping and host defence ­functions by targeting OSEs on the surface of ­apoptotic cells, cells ­undergoing no clearance no defense While the absence of a functional immune Microparticles are small (0.1 – 1 μm) vesicles ­programmed cell death ­system can cause severe immune disorders, released by cells, including those of the immune (apoptosis), self antigens, and microbial agents. a ­fully functioning immune response in certain system, and have diverse functions including Insufficient NAb titers settings can also cause diseases, such as the promoting inflammation. Christoph Binder’s may lead to impaired chronic inflammatory disease atherosclerosis. group has recently discovered that micro­ ­clearance of cellular debris and reduced protective Atherosclerosis is caused by high levels of particles display so-called malondialdehyde MDA NAbs binding to OSEs capacity from invading ­cholesterol in the blood leading to the pres- (MDA) adducts, which are oxidation specific pathogens. ­Accumulating ence of low density lipoproteins in the blood epitopes, on their surface. These MDA adducts ­apoptotic material can trigger auto-immune oxCL vessel walls. These low density lipoproteins ­mediate an inflammatory response, which can Dying cell responses and promote become oxidised and are subsequently recog­ be blocked by naturally occurring IgM antibodies PC chronic ­inflammatory disease. Adapted from nised by the immune system leading to a and ­complement factor H. They are now testing Tsiantoulas et al., Frontiers chronic ­inflammatory response. Over several whether these MDA-adducts on microparticles in ­Immunology 2013. decades this process results in the formation of also mediate thrombosis upon ­atherosclerotic 4-HNE ­atherosclerotic plaques containing the ­oxidised plaque rupture, which could lead to novel infectious pathogens, microbes, etc. low density ­lipoproteins and immune cells. ­diagnostic biomarkers and the development These plaques can eventually rupture, triggering of therapies. the ­formation of a blood clot (thrombus)­ that “house keeping” functions first line defense can block the ­vessel and lead to a myocardial In addition, the Binder group is currently clearance & neutralization ­infarction or stroke. Scientists in ­Christoph ­studying how the recognition of oxidation ­Binder’s group at CeMM have recently ­specific epitopes by natural antibodies helps been ­studying the role of ­microparticles in to protect against chronic inflammation, which ­inflammation andthrombosis ­ formation, and could be involved in a wide range of different­ how this relates to disease ­progression. diseases including pulmonary, renal and liver disease, as well as Alzheimer’s disease and multiple sclerosis. PhD students Dimitrios Tsiantoulas and Sabrina Gruber from Christoph

Binder’s group presented this topic in a recent Natural IgM antibodies review published in the journal Frontiers in Immunology (Tsiantoulas et al., 2013). The aim of these projects is to identify disease-relevant molecular mechanisms, which could be exploited to provide novel therapeutic approaches for these pathological conditions.

Ce — M­—M­— Research Report 2013 Science 44 45 Post-Genomic Bioinformatics Helping to manage and exploit some of the Methods ­(Varjosalo et al., 2013), see below for large datasets generated by mass spectrometry more details. ­Further ­computational work led are the bioinformaticists, headed by Jacques to the innovative ­mapping of non-sequence ­Colinge, who have developed tailored ­statistical specific nucleic acid-protein ­interactions Technologies and ­computational frameworks to enable users (­Dürnberger et al., Genome Biology 2013) as to sort through complex data and make novel well as the ­development of advanced ­statistical ­discoveries. Recent work performed in the tools to ­identify and quantify ­posttranslational Superti-Furga, ­Bennett and Colinge groups led ­modifications in mass spectrometry data to a publication in the high profile journal Nature (­Breitwieser & Colinge, J Proteomics 2013).

The Major Drivers of New Scientific Discoveries featured in several prominent CeMM publications in Technological advance has always been a significant­ 2013, including work from Robert Kralovics’ group driver of scientific discovery. Once tools aredeveloped ­ (Klampfl et al., NEJM 2013), and KaanBoztug’s ­ Fig. 5 Experimental that enable scientists to answer questions­ that group (Salzer et al., Blood 2013), as well as in the ­characterization of the were previously considered inaccessible, ­substantial ­collaborative project on Haploid Genetics with ­human non-sequence- gains can be made in established fields, sometimes ­Haplogen (Bürckstümmer et al., Nature Methods specific nucleid acid interactome. 219 proteins leading to dogmas being overturned or the birth of 2013). For more details on these projects, see the were assigned binding

HIST1H4L SMARCAL1 HNRNPAB CGGBP1

HNRPDL

HNRNPD SHMT2 UHRF1 preferences for at least C20orf72 SRSF3 ­completely new fields. As an institute operating in chapters on cancer and immune system disorders PES1

XRCC1 NCL POLG one nucleic acid subtype PARP1 POLR3A RFC2LIG3 ZFP91 SRSF5 SRP14 MSH2 SRSF7 YBX1 CIRBP POLR3B LIN28B PEG10 the post-genomics era (i.e., at a time when entire in this report, and below. POLB G3BP2 HIST1H1CPOLR3F MPG NXF1 KLF16 SUB1 RBM4 HMGB3 MKI67IP and clustered by ­binding RBM28 POLG2 RNASE3 FAM98B RBM14 MSH6 GRSF1 PARP2 EXOSC6 genomes, both healthy and diseased ones, can be H1F0 ATP5D preference similarity in SSBP1 POLR2E MARCKS MSH3 SRP9 HMGB2 RBM3 RFC4 CSDA XRCC5 SRSF2 an affinity fingerprint XRCC6 RSL1D1 relatively easily accessed and explored), CeMM has Mass Spectrometry and Proteomics SRSF6 ZNF787 POLR1CHMGB1TFAM HNRNPM TIA1 ­dendrogram. Most protein TIAL1 TOP1 U2AF2 DDB2 PCBP2 invested heavily in the development of a suite of Another technology central to many CeMM projects TRMT6 families show similar POLR3CDDB1 PTBP1 RFC3 SREK1 PUF60 G MATR3 binding preferences, modern tools and technologies to ­promote its own is mass spectrometry, which has helped to ­generate BANF1LYZ LSM6 mCG C U RPA3 LSM1 T RPA2 CPSF1 GEMIN5 while H1FX, for instance, A RPA1 NAA38 disease relevant research as well as to provide­ tools high resolution protein ­interactomes, identify PRKDCRFC1 LSM3 RNA RECQL LSM7 was found to be RNA- DNA LSM2 SRSF11 RFC5 and technologies for the local and international drug-protein ­interactions, perform comparative RNASEH1 specific as opposed to the PNKP HNRNPA0 DAZAP1 ­family members H1F0 and HMGA1 ­scientific community. ­quantitative analysis of global proteomes, and FOXK1 DHX16 HNRNPH1 HIST1H1C, which are DNA- CHCHD1 HNRNPF FUBP1 ­monitor the role of post-­translational modifications­ TRMT2A CPSF7 MCM5 KHSRP specific. Adapted from RPS18 NUDT21 FXR1 CPSF6 Dürnberger et al., Genome Next Generation Sequencing in cell signalling pathways. Keiryn Bennett is the RPL19 AUH CKAP4 HNRNPU EWSR1 RPS12 RBM39 Biology 2013. CeMM’s technology suite includes the ­Biomedical head of the Mass Spectrometry and Proteomics RPL4 TARDBP RPL37 SSB ASCC3 HNRNPA1 ZCCHC3 HNRNPA2B1 Sequencing Facility (BSF), which is hosted at CeMM research group at CeMM, and manages a laboratory SRSF9 HNRNPA3 AKAP8 RBM27 CNP DIS3 PRPF8 HIST1H1D and coordinated by CeMM PI Christoph Bock. This is equipped with four mass spectrometers. Each mass LUC7L3 HIST1H1E RPL5 SOX15 RPS4Y2 RPL38 DIS3L2 RPLP2 FTSJ3 Austria’s first ­technology platform dedicated to next ­spectrometer is coupled to a nano-high ­performance EMG1 HNRNPH3 RPS25 TAF15 RPS2 API5 SNRPA1 ACLY ­generation sequencing­ in biomedicine, and is part liquid chromatography (HPLC) system for on-line SNRPD1 PSPC1 RPL31 TRIM25 DDX3X GTPBP10DDX17 EEF1E1 of the joint genomics core facility of the Medical liquid chromatography mass spectrometry. An RNMT RBM15 DAP3 SFPQ NONO RBMX DHX15 ­University of Vienna and CeMM. The facility offers additional HPLC is available for peptide and protein MRPS7 CSTF2 MRPL16 YTHDF3 RPS4Y1 LDHB RPL21 CELF2 DDX5 DDX3Y sequencing using the Illumina HiSeq platform, fractionation. CAMK2G FAM98A RBM19 DDX1 EIF3M C14orf166 HSD17B4 H1FX SND1 which is currently the ­preferred ­technology for many ZC3HAV1 POLD1 HSDL2 HNRNPR DHRS2 PABPN1 DECR1 SYNCRIP RPL24 applications, as well as advice for other sequencing­ SNRPD3 CWF19L1DUS3L MRM1 RPL27 RPS14 CDC5LASPH SRSF1 STAU1 ­technologies. Sequencing performed at the BSF has MOGSTFPI IGF2BP1 EIF2AK2 DKC1 ELAVL1 NARS LUC7L RPS15 TFB2MBYSL IGF2BP3 RPL22 RPS9 DDX18 ILF2 RPL26 RPL8 DDX56 RPL27A MRPS12 RPS13 PRPF31NOP9 RPS17 HEXIM1ESF1 RPL17 IGF2BP2 RTCA RPN1 FGFBP1 SNRPC RPL35 RPS11 ILF3 RPS3 GRWD1 RPS4X RPL15PUS1 DHX9 RPS15A RPS24 RPS3A IMP3 RPL23A RPL3 SNRNP70 NOP56 MYBBP1A NOP16 EIF2S1 ZC3H4 RPL26L1

NSUN2 EIF2S3 NOC4L EIF2S2 HADHBLARP1PECR

LLGL2SLIRP KARS EHHADH TPM3 HNRNPK RPL18 UPF1 RBM42 LRPPRC TARS2 HARS2 DDX28 PTBP3

SYNE1

POLRMT

Science 46 47 Chemical Biology Resources Developing Haploid Genetics Tools for the Scientific Community

Also based at CeMM is the Platform Austria for Gen-AU program of the Austrian Ministry of ­Chemical Biology (PLACEBO); a comprehensive­ Science and Research. The project is now open chemical screening platform that enables the on a ­collaborative basis to the wider scientific Scientific research hugely benefits from As an indication of things to come, scientists CeMM and ­identification and characterisation of small ­community. PLACEBO is headed by Stefan ­collaborative efforts between different in the laboratory of CeMM adjunct PI Thijn molecules for studying biological processes and Kubicek and provides chemical ­biology resources ­laboratories, as illustrated by the study above. ­Brummelkamp, in collaboration with scientists Haplogen­ have developing drugs. It was initiated as a partner- including a 92,000 compound library, and high- It also benefits from the development and sharing at the Radboud University (Netherlands) and been developing ship between CeMM and seven other Austrian throughput and high-content ­screening. of valuable tools. In another project, performed ­Harvard University (US), used haploid cell lines the largest research groups, and funded under the as a partnership between scientists at CeMM and to identify genes required for coupling sugar haploid­ human Haplogen, a powerful new human genetics tool groups to the dystroglycan protein. Defects in has recently been developed, which will benefit these genes make cells insensitive to infection cell line collection groups at CeMM as well as the broader scientific by Lassa Fever virus, which causes hemorrhagic ­available to date. community. fever, but they also cause a severe hereditary Haploid Genetics Tools disease called Walker-Warburg syndrome, which Over the past three years, as part of a public- is characterized by brain, muscle and eye defects. private partnership, Haplogen and CeMM have The identification of these genes using this been developing a large collection of human approach, which was published in the prestigious And finally to haploid genetics, which has EMBO Gold Medal in 2013. It has now been cell lines that are deficient for single genes. journal Science (Jae et al., 2013), further highlights ­recently emerged as an important new tool used to produce a haploid cell library in a joint ­Classical human cell lines are highly hetero­ the value of haploid genetics technology, and in human cells that can be used to make effort by CeMM and the biotechnology company geneous, ­making them very difficult to control could lead to the development of new treatments. ­scientific discoveries that were unobtainable ­Haplogen, which was published in the journal when performing genetic experiments. This with ­previous methods. This ­technology was Nature Methods (Bürckstümmer et al., 2013). limits their value particularly for drug ­discovery The haploid cell collection was made ­possible originally ­developed by CeMM adjunct PI See below for more details. efforts and studying gene function. This new by the partnership between academic research Thijn ­Brummelkamp who won the ­prestigious ­collection circumvents this problem as each at CeMM and private investment by Haplogen,­ cell line ­carries only a single, known, gene along with financial support from ZIT mutation in an ­otherwise identical genetic (­Technology Agency of the City of Vienna). background. Obtaining­ human cells where an The technological advances involved in the Fig. 6 Gene-trapped A D KBM7 mutant clones ­mutants are reversible and individual gene is inactivated had previously ­development of this collection were recently can resemble gene knock- been ­difficult because they carry two copies of published in the journal Nature Methods outs. (A) Summary of the distribution of all gene-trap each gene (i.e. are diploid). Thijn Brummelkamp, (Bü­rckstümmer et al., 2013). At that time, the integration sites mapped USP2 RNF213 BMF EFCAB2 REX04 TNFRSF1A RNF220 VAV1 ELF1 CDH23 RNF157 PIK3CB founding member of Haplogen and Adjunct PI ­collection included cell line clones covering USP2 in the high-throughput at CeMM, presented a solution with the inven- 3,000 different human genes, which represents sequencing pipeline. Genomic RNF213 tion of haploid genetics technology. about one third of all the genes that are active (B) Schematic of the Insertions BMF retro­ viral­ gene-trap n=23468 in these cells. Haplogen is continuing to expand ­vector and PCR analysis of EFCAB2 genomic DNA from three REX04 This technology was further developed by its repertoire of mutant haploid cell lines. clones is shown. (C) West- TNFRSF1A ­Haplogen and subsequently used to create the The ­current collection can be explored at ern blot of KBM7 cells with 1.4% Exon (coding) RNF220 haploid collection, which is the largest human clones.haplogen.org. a gene trap disrupting p53 3.5% Exon (UTR) ­expression, with and with- VAV1 cell line collection available to date. At Haplogen 27.6% Intron (sense) out Cre recombinase treat- ELF1 this collection is being used as an indispensable 22.9% Intron (antisense) ment and parental KBM7 CDH23 tool for the research and development of anti- cells as negative control. 44.7% Intergenic RNF157 (D-E) Overview of RT-PCR viral medications for treating a wide range of and Western blot analysis PIK3CB ­harmful infectious diseases. It is also expected of the indicated clones, to fuel ­academic research in molecular medicine respectively. Adapted B C KBM7 mutant clones from Bürckstümmer et al., where the vast majority of human genes await ­Nature Methods 2013. IoxP IoxP ­functional characterization. Indeed, several LTR SA-GFP polyA groups at CeMM are using it to study host-­ Cre-mediated NFATC2 TEC ELF1 PTEN P53 BTK HCK CYLD IFI16 JAK2 RB1 NFATC2 pathogen interactions and mechanisms of drug excision IoxP action. LTR TEC ELF1 C Clone1 C Clone2 C Clone3 - - + - - + - - + Cre PTEN P53 BTK HCK C C p53 CYLD - - + Cre IFI16 P53 JAK2 Tubulin Ce — M­—M­— Research Report 2013 RB1 Science 48 49 Fig. 7 Systems Biology­ Pushing the Limits of a Technology Charter establishing the “The Core Kinome ­Interactome” project ­alliance known as “The Alpine Zurich – ­Vienna ­Connection”. A joint Testing the reliability and pushing through the The success of this project was critically­ ­research effort between boundaries of new technologies is critical for ­dependent upon the recent progress in CeMM and the ETH ­Zurich ­demonstrates in seeing their potential realised. This was done in ­sensitivity, throughput and specificity of a a ­systematic study of the a recent joint research project between CeMM ­technique known as affinity purification coupled intra- and interlaboratory­ ­reproducibility of a and ETH Zurich, and has made the golden goal to mass spectrometry (AP-MS). Having been ­standardized ­affinity of mapping all protein interactions within the ­successfully used in yeast and Drosophila, this ­purification-mass human proteome readily achievable. ­Researchers technique has become ideal for the large-scale ­spectrometry protocol, that high ­reproducibility in Giulio Superti-Furga’s group at CeMM analysis of human protein complexes. However, can be achieved, ­providing and Matthias Gstaiger’s group at the Institute there are important technical limitations, in a hint at the ­feasibility of Molecular Systems Biology, ETH Zurich, particular in reproducibility between different of a large-scale human ­interactome project together demonstrated the high intra- and inter- groups. The available public data revealed that through interlaboratory laboratory reproducibility of a standardized on average only 25% of an individual protein’s efforts. The charter testifies the a priori commitment of affinity purification-mass spectrometry protocol. interactions were reproduced in an independent the signees to perform this The study would not have been feasible without experiment, highlighting differences between research strategy towards the integral involvement of the laboratories of experimental systems and/or data processing a change in the standards of inter­action proteomics Keiryn Bennett and Jacques Colinge at CeMM, pipelines. for systems biology, not to and of Ruedi Aebersold, director of the institute change it until completion and success and not to at ETH. To address this shortcoming, the team conducted criticize “a posteriori”. a large-scale comparative study in two separate Artwork by Giulio Superti- A comprehensive understanding of how ­ laboratories (and countries) by each analysing the Furga. proteins interact with each other is a Rosetta protein interactions of 32 human protein kinases stone for the interpretation of the genome. using affinity purification and AP-MS analyses. Only then can the role of individual gene The experiment took three years and involved ­products be fully understood,­ as each one’s the standardization of experimental parameters ­function is ­intimately connected with the and cross-laboratory training of scientists. The ­function of ­others. ­Previously, the focus had project was performed maintaining most of the been on studying the function of individual mass spectrometry instrumentation settings genes and proteins. More recently it has become typical of the individual laboratories, to mimic clear that ­studying the functional organization as much as possible realistic conditions for future of the entire human ­proteome is required to multi-laboratory efforts. ­decipher the ­orchestration of cellular processes at a systems level. Considering that only a tenth The final network produced from these of the more than half a million protein-protein ­experiments is composed of 488 protein ­interactions in human cells have been experi- ­interactions, 364 of which were novel. This mentally observed so far, it has become clear ­represents the largest AP-MS data set on the that a ­complete ­characterization of the human human kinome published to date. The data ­interactome can only be achieved by a collabo­ ­generated were highly reproducible in the rative scientific effort. ­partner laboratory (81%), with the ­biochemical experiments being the largest cause of data ­variation. The study was published in Nature Methods (Varjosalo et al., 2013). This unique Zurich-Vienna effort demonstrated that this technology is highly robust, and can now be ­confidently used in an inter-laboratory effort to map the entire protein machinery of a human cell.

Ce — M­—M­— Research Report 2013 Science 50 51 The Hunt for New Diagnostics and Biomarkers and Drugs

Defects in the incidence of epigenetic marks Another alternative approach has been developed such as DNA methylation tend to occur early in Sebastian Nijman’s group, where scientists Therapeutics during cancer development and are thought to are using isogenic cancer models and haploid correlate with ­disease severity and response to ­genetics that they have been developing to treatments. This makes them promising targets ­identify ­synthetic lethal interactions. These for biomarker development. In Christoph Bock’s genetic ­interactions can potentially be exploited group at CeMM, researchers have established an to develop new drugs targeted to certain types epigenetic ­biomarker platform that they are using of cancers. And together with long-time CeMM From the Clinic to the Clinic to systematically derive, prioritize and validate ­collaborator Eric Haura and colleagues from The research conducted at CeMM tackles ­significant DNA methylation biomarkers in cancer as diag- the H. Lee Moffitt Cancer Center and Research biomedical challenges with an emphasis on ­cancer, nostics for personalised medicine. Their work is Institute in the US, the groups of Keiryn ­Bennett, immune disorders and infectious diseases. In keeping­ performed in the context of the European BLUE- Jacques Colinge and Giulio Superti-Furga have with CeMM’s mission “From the clinic to the clinic”, PRINT project and the International Human together been harnessing the power of systems there are several projects that are ­specifically focused Epigenome Consortium. biology to discover novel therapeutics for on the development of innovative diagnostics­ and ­treating patients with lung cancer, including therapeutics, some of which could have an immediate For many diseases, the hunt is also still on those that have developed resistance to known impact in the clinic. for effective drugs. Classical drug screening drugs. See below for more details. approaches have yielded important but too An accurate diagnosis is absolutely required for few successes. To address this shortfall, scientists Even when drugs are available, it is surprising­ ­optimal clinical management of any disease. at CeMM have been developing and utilising how little is understood about how they ­Biological markers identified through scientific novel ­technologies and tools as alternative drug ­actually work, particularly on the molecular research have been highly valuable for supporting target discovery approaches. These include level. ­Scientists in Giulio Superti-Furga’s group the medical profession in making accurate diagnoses, ­PLACEBO (Platform ­Austria for ­Chemical are working on ­characterizing the mechanism as well as providing important new understanding ­Biology), which provides ­chemical ­biology tools of action of known drugs. They use systems- of the mechanisms underlying diseases, which can for high-throughput and high-content ­screening. level approaches comprising transcriptomics, lead to the development of new treatments. Disease This technology is being used in the Christian­ haploid cell genetics and ­chemical proteomics, ­biomarkers are also crucial for tailoring specific ­Doppler laboratory, which is a public-private­ which are established at CeMM, to ­elucidate ­therapies to the individuals most likely to benefit partnership between CeMM, ­Boehringer how a specific drug, such as an anti-cancer drug, from them, which is known as personalised medicine. ­Ingelheim, and Haplogen, headed by CeMM’s can target cancer cells and inhibit molecular This is also important for the success of candidate Stefan Kubicek, in order to identify potential processes that result in cell death. This informa- drugs undergoing clinical trials. Unfortunately, there new drugs and diagnostics for a variety of tion is ­important for the development of new have been some notable failures of drugs that have different­ diseases. ­generations of potentially more effective drugs, not been clinically approved because of the absence and for ­understanding the development of drug of a biomarker, which meant that the patients were ­resistance, which is a major clinical problem. not stratified during the trial, and not because the drug was ineffective. However, identifying useful ­biomarkers for diseases can be quite challenging.

Science 52 53 Fig. 8 Perturbation of the A Systems Approach to Drug Discovery mutated Epidermal Growth Factor ­Receptor (EGFR) interactome ­identifies vulnerabilities­ and ­resistance mechanisms. A graphic rendition of the GLU2B Most cellular processes, such as growth and They began by using tandem affinity purification GRP78GRP78 coherent drug network ­differentiation, are controlled by complex to identify all the proteins that bound to a cancer- derived from the core CEP-701 physical EGFR interactome ­intracellular signaling pathways, which are associated EGFR mutant and wild type EGFR Vandetanib integrated with kinase composed of many different types of molecules. protein expressed in two selected lung cancer cell Midostaurin inhibitors derived from TAE-684 competition binding assays For example, when a cell should be proliferating, lines. Bound proteins were identified by liquid Flavopiridol is shown. Midostaurin and extracellular growth factors such as the epidermal­ chromatography mass spectrometry (LC-MSMS). Lapatinib lestaurtinib (CEP-701) can SKI-606 growth factor (EGF) are produced that bind to To expand this initial protein-protein interaction overcome drug resistance R547 in EGFR-mutated lung their cognate receptors on the surface of the network (i.e., ‘interactome’) they selected some HKI-272 GSK-1838705A cancer cells through direct ­target cell, triggering a cascade of activity inside of the newly identified proteins and repeated EGFR CDK9 EGFR inhibition, when that cell. This activity involves many different the process. These ­experiments were also com- Dasatinib combined with erlotinib. Blue nodes (proteins) high- proteins, including kinases and phosphatases, plemented by identifying all of the proteins that light EGFR-specific core Staurosporine which can chemically modify and thereby alter were modified by tyrosine ­phosphorylation in R406 proteins for cell ­survival, EGFR red nodes highlight the activity of a select group of target proteins. one of the lung cancer cell lines treated with an AZD-2171 BIBW-2992 T790M ­non-specific core proteins. The cascade eventually reaches the cell nucleus EGFR inhibitor. Rectangles and ellipses EXEL-2880 CI-1033 and leads to the activation and repression of are bait and prey proteins, respectively, identified by a gene expression program. This program is Collectively, the data could be assembled into a Erlotinib tandem affinity purification designed to produce an array of specialized coherent interactome. Selected proteins in the or phosphoproteomics. Red lines indicate ­inhibitor ­proteins such as those involved in biosynthesis interactome were then depleted using RNA – protein interactions, to enable the cell to grow. interference to identify those that are required ERRFI Hexagons­ are inhibitor for viability of three different lung cancer cell drugs and their colour is related to ­inhibitor The capability of signaling pathways to control lines. Finally, to uncover new combinations of Kd. ­Figure adapted a cell makes them vulnerable to mutation ­during drugs that could be more effective for treating based on Fig. 6B from Li et al., ­Molecular Systems the development of diseases such as cancer. lung cancer, particularly EGFR inhibitor resistant­ ­Biology 2013. For example, the receptor for EGF, known as lung cancer, they went on to identify drugs that EGFR, is often found mutated or aberrantly are known to interact with some of the core expressed in several different types of cancer components of their interactome and generated a including lung cancer. Lung cancer is one of the drug network, which they also tested for efficacy most deadly cancers, and treatment options are in vitro. This large body of work was published in severely ­limited. Although EGFR inhibitors the journal Molecular Systems Biology (Li et al., have worked to a certain extent in the clinic, they 2013), and has provided many new avenues for do lead to the development of drug resistance, future research. By following a systems approach, ­necessitating the identification of alternative the team has uncovered new insights into EGFR treatment ­approaches. Scientists in the groups of inhibitor resistance mechanisms and suggested Giulio Superti-Furga, Jacques Colinge and Keiryn feasible and urgently needed treatments that Bennett at CeMM, together with the group of could be used to overcome this resistance in lung Eric Haura in the US, hypothesised that if they cancer patients. could comprehensively map all the proteins that bind to the mutated forms of EGFR, which are found in lung cancer, this may help to identify new anti-cancer drug targets, and alternative ­treatment strategies to overcome drug resistance.

Ce — M­—M­— Research Report 2013 Science 54 55 Denise P. Keiryn L. Principal Barlow Bennett Epigenetic Mechanisms Mass Spectrometry and Proteomics in Development and Disease

Investigators Denise Barlow is a British national who joined CeMM in 2003 Keiryn Bennett obtained her Bachelor­ of Science with First and is an Honorary Professor at the ­University of Vienna. She Class Honours from the University of ­Tasmania; and her initially trained as a State Registered Nurse in the UK and Ph.D. in ­protein mass spectrometry from the ­University afterwards completed her undergraduate studies at Reading­ of ­Wollongong, Australia. She spent 2½ years as a post­ University (UK) and a Ph.D. on the interferon system in doctoral fellow in the ­laboratory of one of the fore­ ­fathers early mouse development at Warwick ­University (UK). of modern-day protein mass ­spectrometry, Professor Peter Post-­doctoral work studying mouse embryonic ­development ­Roepstorff, (Odense, Denmark). This was followed by 4 years followed at ICRF (London, UK) with Dr. Brigid Hogan, under the supervision of Matthias Mann at MDS ­Proteomics and on genome biology at EMBL (Heidelberg, D) with (Odense, Denmark). She is respected worldwide in the field Dr. Hans ­Lehrach. She has also held group leader ­positions of protein mass spectrometry and proteomics, with more at the IMP (Vienna, A) and the NKI (Amsterdam, NL). On than 17 years of experience including­ 4 years ­managing a high- returning to Austria in 2000, Denise was appointed Head throughput ­industrial ­proteomic ­laboratory. She joined the of the Dept. of Developmental Genetics at the ­Austrian laboratory of Giulio Superti-Furga in 2004 and ­established ­Academy IMB Institute (Salzburg, A), and then returned the mass spectrometry/proteomic research group at CeMM. to Vienna in 2003 as a ­Principal ­Investigator with CeMM. Since 2009, Keiryn Bennett has had an ­independent group One of the Barlow lab’s major achievements was the discov- leader ­position and ­currently the ­laboratory consists of a ery in 1991 of the first imprinted gene in mammals to show total of 4 people. The mass spectrometry research group is parental-specific gene expression. Her group’s subsequent ­currently focused on: monitoring the phosphorylation events identification that ­epigenetic silencing of this imprinted of kinase substrates; understanding the role of HDAC1 and gene is induced by expression of an unusual long non-coding HDAC2 in T-cell ­proliferation; and investigating the ­cellular (lnc) RNA, has led them to investigate how lncRNAs act pathways involved in ­oxidative stress. These research areas throughout the mouse and human genome as regulators are ­supplemented by ­technological advancements in protein- of gene expression in development and disease. The lab uses protein and drug-­protein interactions, chemical crosslinking,­ the model of genomic imprinting to dissect how lncRNAs quantitative-, and post-translational­ modi­ fication­ ­epigenetically silence genes, and together with high through- ­proteomics. put sequencing technology is extending these results into the mouse and human genome with the goal of understanding how lncRNAs play a role in human diseases such as cancer. Main Research Interests + Proteomics of innate immunity/immunology + Proteomics of protein-protein interactions including Main Research Interests chemical crosslinking; and protein-drug interactions + Moleular basis and function of genomic imprinting + Phospho-, acetyl- and quantitative proteomics in mice and humans + Integration of mass spectrometry with biology + Identification and characterization of macro long and ­bio­informatics non-coding (lnc) RNAs in the mouse and human genomes + The potential of macro lncRNAs as tumor biomarkers Relevant/Important Publications in human cancer ­Giambruno R, et al. Affinity purification strategies for proteomic analysis of transcription factor complexes. J Proteome Res. Relevant/Important Publications 2013;12(9):4018-4027. Barlow DP, et al. Genomic imprinting in mammals. Rudashevskya EL, et al. A method to resolve the composition of Cold Spring Harb Perspect Biol. 2014 Feb 1;6(2). pii: a018382. heterogeneous affinity-purified protein complexes derived from Kornienko AE, et al. Gene regulation by the act of lncRNA a common protein by chemical crosslinking, gel electrophoresis ­transcription. BMC Biol. 2013 May 30;11:59. Review. and mass spectrometry. Nat. Protoc. 2013;8, 75-97. Latos PA, et al. Airn transcriptional overlap, but not its lncRNA Bürckstümmer T, et al. An efficient tandem affinity ­purification product, induces imprinted Igf2r silencing. Science. procedure for the characterisation of protein complexes 2012 Dec 14;338(6113):1469-72. in ­mammalian cells. Nat. Methods. 2006;3, 1013-1019. Santoro F, et al. Imprinted Igf2r silencing depends on continuous Ho Y, et al. Systematic identification of protein ­complexes Airn lncRNA expression and is not restricted to a developmental in ­Saccharomyces cerevisiae by mass spectrometry Nature. window. Development. 2013 Mar;140(6):1184-95. 2002;415: 180-183.

Science 56 57 Andreas Christoph Christoph Kaan Bergthaler Binder Bock Boztug

Viral Pathogenesis and Immunopathologies Atherosclerosis and Immunity Medical Epigenomics and Genetics and Molecular Pathophysiology Next Generation Sequencing of Inborn Errors of the Immune System

Andreas Bergthaler, born 1977, joined CeMM in 2011. He Christoph Binder was born in 1973 in Vienna, Austria. Christoph Bock is a Principal Investigator at CeMM, a guest Kaan Boztug, born in 1977, was appointed as a Principal studied veterinary­ ­medicine at the University of ­Veterinary ­Following his studies of medicine at the Medical Faculty professor at the Medical University of Vienna’s ­department Investigator at CeMM in January 2011. He studied Medicine ­Medicine in Vienna and spent clinical and research stays at of Vienna University, where he obtained his M.D. degree for laboratory medicine and the co­ordinator of the Bio­­medical at the Universities of ­Düsseldorf, Freiburg and London. For the Royal (Dick) School of Veterinary Studies, Edinburgh, in 1997, he entered a Ph.D. program at the University of Sequencing Facility at CeMM. His research focuses on his M.D. thesis, he spent a year of research in the ­laboratory the University of Tokyo, the University of Zurich and the ­California in San Diego. Working with world-famous ­medical epigenomics, studying the role of DNA methylation­ of Iain L. Campbell at the Scripps Research Institute, La Jolla, ­Danish ­Veterinary Institute,­ Copenhagen. For his ­graduate ­atherosclerosis researcher Joseph Witztum, he obtained in cancer and developing methods for rational design of CA, USA, where his work was focused on neuroimmu­nology. studies he joined the Institute­ of Experimental Immunology his Ph.D. degree in 2002. In 2005, he joined the Department­ ­epigenetic cancer therapies. He graduated from the Max From 2005 until 2010, Kaan Boztug worked at ­Hannover at the University/ETH Zurich (Profs. Hans Hengartner and of Laboratory Medicine at the Medical­ University of Vienna, Planck Institute for Informatics and Saarland University Medical School in the ­Department of Pediatric Hematology/ Nobel Laureate Rolf Zinkernagel). After postdoctoral work where in 2009 he was appointed Professor of ­Atherosclerosis in 2008, and there he has been an adjunct group leader for Oncology headed by Christoph Klein with a dual affiliation­ in Zurich and in the labora­tory of Prof. Daniel Pinschewer Research, in 2006 he joined CeMM. He is a specialist in ­computational epigenetics since 2009. As a postdoctoral ­combining clinical training and postgraduate laboratory work. at the University of Geneva he joined Prof. Alan Aderem’s Laboratory ­Medicine and leads a research group focusing research ­fellow at the Broad Institute of MIT and Harvard, He developed a strong interest in the molecular ­genetics group at the Institute for ­Systems Biology in Seattle, WA. on the role of immune functions in atherosclerosis and ­Christoph Bock ­contributed to the work of the ­Roadmap of primary immundeficiency disorders and was able to In 2011 he co-founded a vaccine start-up company.­ Andreas how these can be exploited for therapeutic interventions. ­Epigenome ­Mapping Consortium. He joined CeMM in 2012, ­elucidate a novel primary immunodeficiency which combines Bergthaler’s research is focused on the molecular basis of He first described the ­athero­protective effect of pneumo­ and his lab is involved in the International Human ­Epi­genome ­con­genital neutropenia and complex organ mal­formations, how viral infections cause disease and immunopathology. coccal ­vaccination of the natural IgM T15/E06 (Binder et al., ­Project and in several EU project consortia aimed at dis- caused by deficiency in the ­glucose-6-phosphatase catalytic To this end the Bergthaler ­laboratory studies viral infections 2003). His research group discovered that certain oxidation- secting the role of ­epigenetics in cancer through large-scale­ subunit 3 (G6PC3). In another sentinel work, he was one of in mouse models through an interdisciplinary approach of specific epitopes are major targets of natural antibodies ­epigenome ­mapping. In 2009, ­Christoph was awarded an the lead authors in the identification of the first monogenic ­patho­logy, molecular biology,­ ­virology, immunology and (Chou et al., 2009) and of complement factor H (Weismann Otto Hahn Medal by the Max Planck Society for pioneering causes of childhood inflammatory bowel disease (IBD), systems biology. The employed experimental models bear et al., 2011). He also first identified the atheroprotective roles work in ­computational ­epigenetics. caused by mutations in the genes encoding the interleukin-10 ­patho-­physiological relevance to human disease and provide and ­mechanisms of the cytokines IL-5 (Binder et al., 2004) receptor. At CeMM, Kaan Boztug works on the genetics of definedexperi ­ ­mental systems to gain mechanistic insights and IL-13 (Cardilo-Reis et al., 2012). He has won ­numerous primary immundeficiencies and congenital bone marrow through targeted ­perturbations. This enables his group ­prestigious fellowships and awards and has authored Main Research Interests failure syndromes but has also broadened his interest to to ­dissect novel ­molecular determinants and interaction >70 publications in important journals, including Nature + Epigenomic basis of hematopoietic diseases genetics of malignant disorders of childhood. He holds a dual networks that impact viral pathogenesis and the antiviral ­Medicine and Nature. + Bioinformatic dissection of cellular identity appointment with the Children’s Hospital of the ­Medical immune system. Eventually,­ this may pave the way for the + Diagnostics using next generation sequencing University of Vienna. In 2012, he received the START Prize development of much-sought clinical treatments against of the Austrian Science Fund (FWF) and a Starting Grant of human viral diseases such as hepatitis, immuno­suppression Main Research Interests Relevant/Important Publications the European Research Council (ERC StG). He is the director and superinfections. + Role of innate immunity in inflammation Bock C., et al. Analysing and interpreting DNA methylation data. of the newly established CeRUD Vienna Center for Rare and and oxidative stress Nature Reviews Genetics. 2012; 13: 705-719. Undiagnosed Diseases. + Elucidate the protective capacities Bock C, et al. Managing drug resistance in cancer: Main Research Interests of natural lgM antibodies in atherosclerosis lessons from HIV therapy. Nature Reviews Cancer. + Viral pathogenesis + Discover ways to modulate natural immunity Main Research Interests 2012; 12: 494-501. + Antiviral immune responses as therapy for cardio-vascular diseases + Molecular genetics of primary immundefiencies + Mouse infection models Bock C, et al. DNA methylation dynamics during in vivo and congenital bone marrow failure syndromes + Systems biology Relevant/Important Publications ­differentiation of blood and skin stem cells. Molecular Cell. 2012; + Molecular genetics of malignant hematological Cardilo-Reis L, et al. Interleukin-13 protects from atherosclerosis 47: 633-647. disorders of childhood Relevant/Important Publications and modulates plaque composition by skewing the macrophage Bock C, et al. Reference Maps of human ES and iPS cell variation Kreutzfeldt M*, Bergthaler A*, et al. Neuroprotective phenotype. EMBO Mol Med. 2012 Oct;4(10):1072-86. Relevant/Important Publications enable high-throughput characterization of pluripotent cell lines. ­intervention by interferon- blockade prevents CD8+ Boztug K, et al. A syndrome with congenital neutropenia γ Weismann D, et al. Complement factor H binds malondialdehyde Cell. 2011; 144, 439-452. T cell-mediated dendrite and synapse loss. J Exp Med. and mutations in G6PC3. N Engl J Med. 2009; 360: 32-43. epitopes and protects from oxidative stress. Nature. 2013 Sep 23;210(10):2087-103. Bock C, et al. Quantitative comparison of genome-wide DNA 2011 Oct 5;478(7367):76-81. Glocker E-O*, Kotlarz D*, Boztug K*, et al. Early-onset methylation mapping technologies. Nature Biotechnology. Litvak V, et al. A FOXO3-IRF7 gene regulatory circuit limits ­inflammatory bowel disease caused by loss-of-function mutations Chou MY, et al. Oxidation-specific epitopes are dominant targets 2010; 28: 1106-1114. ­inflammatory sequelae of antiviral responses. Nature. in the IL10-receptor genes. N Eng J Med. 2009; 361: 2033-45. of innate natural antibodies in mice and humans. J Clin Invest. 2012 Oct 18;490(7420):421-5. 2009 May;119(5):1335-49. Salzer E*, Santos-Valente E*, et al. B cell deficiency and severe Bergthaler A, et al. Viral replicative capacity is the primary autoimmunity caused by deficiency of protein kinase C delta. Binder CJ, et al. Pneumococcal vaccination decreases ­determinant of lymphocytic choriomeningitis virus persistence Blood. 2013 Apr 18;121(16):3112-6. ­athero­sclerotic lesion formation: molecular mimicry between and immunosuppression. Proc Natl Acad Sci U S A. Streptococcus pneumoniae and oxidized LDL. Nat Med. (* equal contribution) 2010 Dec 14;107(50):21641-6. 2003 Jun;9(6):736-43. (* equal contribution) Binder CJ, et al. Innate and acquired immunity in atherogenesis. Nat Med. 2002 Nov;8(11):1218-26.

Ce — M­—M­— Research Report 2013 Science 58 59 Thijn Jacques Sylvia Robert Brummelkamp Colinge Knapp Kralovics

Genetics of Cancer and Infectious Diseases Bioinformatics Innate Immunity and Bacterial Infections Genetics of Hematological Disorders

Thijn Brummelkamp uses genetics in human cells to pinpoint Jacques Colinge was born in Switzerland and heads CeMM’s Sylvia Knapp studied Medicine at the ­University of Vienna Robert Kralovics, born 1970, is Czech and joined CeMM in genes that play a role in human disease. His interests are bioinformatics group since 2006. He obtained a Ph.D. in and the Free University in ­Berlin. She obtained her M.D. June 2006. He obtained his first degree in Molecular Biology cancer research, infectious­ disease and drug action. ­During mathematics from the University of Geneva, Switzerland, degree in 1993 and started her residency in Internal Medicine and Genetics at the ­Comenius University in Bratislava and his Ph.D. he developed a system for the ­expression of shRNA in ­collaboration with the Swiss Institute of ­Technology. at the ­University Hospital Vienna. In 2000 she received her later his Ph.D. in Biophysics at the Academy of Sciences of the molecules enabling gene inhibition­ through ‘stable RNA After completing his Ph.D., Jacques Colinge joined the Serono License in Internal Medicine and in 2004 she obtained a Czech Republic in Brno. He did his post-­doctoral work on the interference’. More recently he has developed an approach ­Pharmaceutical Research Institute as a bioinformatician to “Habilitation” in Internal Medicine at the Medical ­University genetics of ­myeloproliferative disorders working with Josef for haploid genetic screens in human cells using insertional­ work mainly on differential gene expression data analysis. of Vienna. After ­several residencies, mostly in areas like Prchal at the University of Alabama in Birmingham, USA. He mutagenesis. He has used this approach to ­identify host In 2000 he moved to GeneProt Inc. to head a group in charge ­Infectious ­Diseases, AIDS and Intensive Care, she became followed Prchal as an Assistant Professor at the ­Baylor College ­factors used by a variety of pathogens, which led to the of mass spectrometry-related ­bioinformatics and parallel a Ph.D. student in Tom van der Poll’s laboratory at the of Medicine in Houston. From mid 2001, he was a project ­identification of the lysosomal cholesterol transporter NPC1 computing. In 2005, he joined the Upper Austrian University ­University of Amsterdam and studied the inflammatory leader with Radek Skoda in Basel. Kralovics’ research interests as the long-sought intracellular receptor for Ebola virus. of Applied Sciences at Hagenberg to serve as a ­Professor of response to severe bacterial ­infections. She joined CeMM in are ­primarily in ­myeloproliferative ­disorders (MPDs) and in He received his M.S. in biology from the Free University,­ Bioinformatics before moving to CeMM in September 2006. 2006 and ­continues her work on the innate immune response ­myeloid malignancies in ­general. One of his major achieve- Amsterdam, in 1998 and did his graduate­ research at the In 2009, Jacques obtained a Habilitation in ­bioinformatics to bacterial infections, focusing on the molecules involved in ments so far has been the ­identification of a gain-of-function ­Netherlands Cancer Institute in the laboratory of Prof. René from TU Graz. The bioinformatics lab does research to the initiation and ­resolution of the innate immune response ­mutation in the JAK2 kinase gene (V617F), which plays ­Bernards. In 2004 he was appointed as a ­Whitehead ­Fellow ­develop data analysis methods aimed at ­unraveling the to clinically relevant pathogens and on the role of bacterial an ­important role in MPD pathogenesis. Robert ­Kralovics to initiate his independent research program in Cambridge, ­functions and ­structure of ­biological networks. The group virulence factors and their interactions with host structures ­continues this work at CeMM to ­identify new mutations USA and in 2011 his laboratory moved to the Netherlands also ­develops statistical models and maintains data ­processing and pathways. Her most important achievements include the ­causing familial pre­disposition to hematological malignancies Cancer Institute and he became an Adjunct Principal pipelines to analyze and manage mass ­spectrometry data. functional characterization of lung macrophages as well as the using advanced genomics approaches, and is working towards ­Investigator at CeMM. For his studies­ he received the Antoni biological function of several pattern ­recognition ­receptors understanding how genetic variability ­contributes to the van ­Leeuwenhoek Award (2003), The Annual NVBMB Award during Streptococcus pneumoniae pneumonia. ­Sylvia Knapp disease. (2004, Dutch Association for Biochemistry and Molecular Main Research Interests maintained her responsibilities at the Intensive Care Unit at Biology), he was chosen as one of the world’s top 35 Young + Computational proteomics the Medical University Vienna and was appointed Professor ­Innovators by MIT’s ­technology Review ­magazine (2005) and + Protein interaction network analyses of Infection Biology in 2012. Main Research Interests received EMBO’s gold medal in 2013. + Systems biology and OMICS data integration + Identify mutations in early steps + Drug mechanism of action and side-effects modeling of disease development in hematological malignancies + Protein complex predictions from mass spectrometry data Main Research Interests + How mutant stem cells evolve genetically, Main Research Interests + Application of computational statistics and mathematics + Exploit molecular mechanisms of host-pathogen interactions how they respond to therapy + Cancer research + Receptor cross-regulation in innate immunity + What gene mutations cause familial predisposition + Infectious diseases Relevant/Important Publications to hematological malignancies + Drug action Colinge J, et al. Building and exploring an integrated human Relevant/Important Publications + How does genetic variability contribute to disease kinase network: global organization and medical entry points. Warszwaska JW, et al. Lipocalin-2 deactivates macrophages and + How to diagnose the diseases in early stages of development Relevant/Important Publications J Proteomics. 2014. pii: S1874-3919(14)00150-X. worsens pneumococcal pneumonia outcomes. J Clin Invest. 2013. Jae, LT, et al. Deciphering the glycosylome of 123: 3363-3372. Relevant/Important Publications Duernberger G, et al. Experimental characterization of the human ­dystroglycanopathies using haploid screens for Lassa virus entry. Klampfl T, et al. Somatic mutations of calreticulin in non-sequence-specific nucleic acid interactome. Genome Biol. Matt U, et al. WAVE-1 mediates suppression of phagocytosis by Science. 2013 Apr 26;340(6131):479-83. myeloproliferative­ neoplasms. N Engl J Med. 2013, 14:R81. phospholipid-derived DAMPs. J Clin Invest. 2013. 123: 3014-3024. 2013.Dec 19;369(25):2379-90. Carette JE, et al. Ebola virus entry requires the cholesterol Pichlmair A, et al. Viral immune modulators perturb the human Baumann CL, et al. CD14 is a coreceptor of Toll-like receptors ­transporter Niemann-Pick C1. Nature. 2011; 477(7364):340-3 Harutyunyan A, et al. p53 lesions in leukemic transformation. molecular network by common and unique strategies. Nature. 7 and 9. J Exp Med. 2010. 207: 2689-2701. N Engl J Med. 2011 Feb 3;364(5):488-90. Carette JE, et al. Haploid genetic screens in human cells identify 2012. 487:486-490. host factors used by pathogens. Science. 2009; 326(5957):1231-5. Olcaydu D, et al. A common JAK2 haplotype confers ­ Colinge J, et al. Systems biology analysis of protein-drug susceptibility to myeloproliferative neoplasms. Nat Genet. Brummelkamp TR, et al. A system for stable expression of ­inter­actions. Proteomics Clin Appl. 2012 Jan;6(1-2):102-16. 2009 Apr;41(4):450-454. short interfering RNAs in mammalian cells. Science. 2002; Breitwieser FP, et al. General statistical modeling of data 296(5567):550-3. Kralovics R, et al. A gain-of-function mutation of JAK2 in from protein relative expression isobaric tags. J Proteome Res. myeloproliferative­ disorders. N Engl J Med. 2005. 28;352(17): 2011 Jun 3;10(6):2758-66. 1779-90.

Ce — M­—M­— Research Report 2013 Science 60 61 Stefan Joanna I. Sebastian Giulio Kubicek Loizou Nijman Superti-Furga

Chemical Biology and Epigenetics DNA Repair and Genomic Stability Functional Cancer Genomics Pathological Networks and the Mechanism of Action of Drugs in Infection and Cancer

Stefan Kubicek, born 1978, is Austrian and joined CeMM Joanna Loizou joined CeMM in 2011. She completed her Sebastian Nijman was born in the Netherlands in 1979. Giulio Superti-Furga is an Italian molecular and systems in August, 2010 . He obtained an MSc in synthetic organic undergraduate studies in the UK, having moved there from He studied medical biology at ­Utrecht University and biologist. He performed his studies at the University Zurich, chemistry from Vienna University­ of Technology following Cyprus. Subsequently, she commenced Ph.D. work at the ­specialized in Molecular ­Biology and Biochemistry in the Genentech, and IMP/Vienna. He was a Post-doctoral fellow a diploma thesis at ETH Zürich. For his Ph.D. in Thomas University of Manchester (and ­University of Sussex) labs of Hans Bos and René Medema. He also holds a Masters at EMBL and later became a Team Leader. He co-founded the Jenuwein’s lab at the IMP in Vienna, he changed fields to ­investigating mechanisms of DNA repair. During this time of Arts degree from the University of Maastricht (Science, biotech companies Cellzome and Haplogen. Since 2005 he Molecular Biology. He then performed post-doctoral research she ­identified for the first time a requirement for the kinase Society and Technology Studies) and was involved in ­clinical directs CeMM. He is a member of EMBO, Austrian Academy­ working on ­Chemical Biology with Stuart Schreiber at the CK2 in the DNA damage response. Postdoctoral work research at a Contract Research Organization. In the lab of Sciences, German Academy of Sciences Leopoldina, Broad ­Institute of Harvard and MIT. Stefan Kubicek heads the ­followed at the International Agency for Research on Cancer of René ­Bernards at the Netherlands Cancer Institute, he ­European Academy of Cancer Sciences, and chair of the EMBL chemical screening platform and PLACEBO­ (Platform Austria (IARC), World Health Organization (WHO), France where performed his Ph.D. work, focusing on ­functional genetic Alumni Association. He obtained an Advanced Investigator for Chemical ­Biology), a task he is well equipped for based on Joanna investigated the role of ­epigenetic ­modifications, screens in cancer-relevant pathways. He performed the first ERC Grant and was made Knight Officer Order of Merit of the previous screening experiences with Boehringer Ingelheim mainly ­histone acetylation, in DNA repair. ­Joanna Loizou RNAi screen in mammalian cells that led to the ­identification Republic of Italy. In 2011 the received the Prize of the City of and at the Broad Institute. These ­activities have resulted in made the fundamentally important finding that cells utilize of the cylindromatosis tumor suppressor as a regulator of Vienna for Natural Sciences, and became “Austria’s scientist the identification of the first selective histone methyltrans- shared molecules in ­transcription and DNA repair. It was also NF-kappaB signaling. This work has led to a rational of the Year”. Among his major achievements to date count ferase ­inhibitor, BIX-01294, and a small molecule inducer ­during this time she chose to work on the immune system ­therapeutic approach for ­treating cylindromatosis. In 2006 the elucidation of basic regulatory mechanisms of tyrosine of insulin expression in pancreatic alpha cells, BRD7389. and showed that histone acetylation is important in main- he joined the lab of Todd Golub at The Broad Institute of kinases in human cancers, the discovery of fundamental Since 2013 Stefan Kubicek also heads the Christian Doppler taining haematopoietic stem cells. She wanted to build on ­Harvard and MIT, USA. There he developed novel genomic organization principles of the proteome of higher organisms Laboratory for Chemical Epigenetics and Antiinfectives, this ­experience and focus on the role of genomic instability­ approaches to discover the functions­ of genes and identify and the development of integrated approaches to understand a public-private partnership between CeMM, Boehringer ­leading to ­cancers of the blood, hence she joined the ­London new angles for cancer treatment. Since joining CeMM in the mechanism of action of drugs at the molecular level. Ingelheim, and ­Haplogen. The Kubicek lab is working on Research Institute (LRI) at Cancer Research UK (CR-UK), 2007, Sebastian Nijman’s research is mostly focused on the His recent work focuses on studying and understanding the the role of ­chromatin in the definition of cell types and cell where she continued to work on DNA repair and its ­identification and understanding of cancer vulnerabilities ­time-resolved molecular impact of perturbations, such as states. Projects focus on defining the contribution of histone ­importance in the development of the immune system and using chemical genetic screens. drugs or viruses, on the human system. methylation to cancer development and progression, the in ­suppressing leukemia and lymphoma. At CeMM Loizou’s development of new assays and compounds to quantify and group investigates the mechanisms by which cells respond to, modulate chromatin modifications, and their potential for and repair, DNA ­damage in order to maintain genomic Main Research Interests: Main Research Interests: trans­differentiation of celltypes with the aim of ­generating ­stability and suppress tumorigenesis. She focuses on + Chemical genetics of cancer + Mechanism of action of drugs new insulin-producing beta cells. ­physiological DNA damage generated by replicative­ stress + Identify novel strategies to treat cancer (cancer vulnerabilities) + Molecular networks affecting leukemias or ­during the process of somatic recombination that occurs + Functional genetic screens to identify cancer-related genes + Molecular basis of innate immunity in immune B and T cells. Joanna is interested in under- Main Research Interests: ­­­­s­tanding the pathways responsible for the repair of such Relevant/Important Publications Relevant/Important Publications + Chemical epigenetics breaks that allow for the ­maintenance of genome ­integrity Nijman SM, et al. Cancer. Potential of the synthetic lethality Huber KVM, et al. Stereospecific targeting of MTH1 + Identification and development of small molecule probes and ­suppression of cancer, but also for the maturation of ­principle. Science. 2013 Nov 15;342(6160):809-11. by (S)-crizotinib as anticancer strategy. for biological processes and host factors in infectious diseases immune cells. Nature. 2014 Apr 10;508(7495):222-7. Bürckstümmer T, et al. A reversible gene trap collection + Contribution of histone lysine methylation to ­empowers haploid genetics in human cells. Nat Methods. Winter GE, et al. Systems-pharmacology dissection cancer development and progression 2013 Oct;10(10):965-71. of a drug ­synergy in imatinib resistant CML. + Role of chromatin in the specification of pancreatic cell types Main Research Interests: Nat Chem Biol. 2012, 8(11):905-12. + Signaling and repairing DNA damage Muellner MK, et al. A chemical-genetic screen reveals Relevant/Important Publications + Repair of physiological DNA breaks generated in a ­mechanism of resistance to PI3K inhibitors in cancer. Pichlmair A, et al. Viral immune modulators perturb the Mair B, et al. Exploiting epigenetic vulnerabilities for cancer immune T and B cells during somatic recombination Nat Chem Biol. 2011 Sep 25;7(11):787-93. human molecular network by common and unique strategies. therapies. Trends Pharmacol Sci. 2014; 35; 136-145. + Maintenance of genome integrity to suppress leukemia Nature. 2012 Jul 26;487(7408):486-90. Brummelkamp TR*, Nijman SM*, et al. Loss of the and lymphoma Kubicek S, et al. Compounds targeting chromatin modifying ­cylindromatosis tumour suppressor inhibits apoptosis by Bürckstümmer T, et al. An orthogonal proteomic-genomic enzyme induce specific cell-type independent transcription ­activating NF-kappaB. Nature. 2003 Aug 14;424(6950):797-801. screen identifies AIM2 as a cytoplasmic DNA sensor for the Relevant/Important Publications ­signatures in the endocrine pancreas. Proc Natl Acad Sci U S A. ­inflammasome. Nat Immunol. 2009 Mar;10(3):266-72. Loizou JI, et al. ATMIN is required for maintenance of genomic (* equal contribution) 2012; 109; 5364-5369. stability and suppression of B cell lymphoma. Cancer Cell. Fomina-Yadlin D*, Kubicek S*, et al. Small-molecule inducers 2011; 19: 587-600. of insulin expression in pancreatic alpha-cells. Murr R*, Loizou JI*, et al. Histone acetylation by Trrap-Tip60 Proc Natl Acad Sci U S A. 2010;107(34):15099-104. modulates loading of repair proteins and repair of DNA double Kubicek S, et al. Reversal of H3K9me2 by a small-molecule strand breaks. Nat Cell Biol. 2006; 8: 91-99. ­inhibitor for the G9a histone methyltransferase. Mol Cell. Loizou JI, et al. The protein kinase CK2 facilitates repair of 2007 Feb 9; 25(3):473-81. ­chromosomal DNA single-strand breaks. Cell. 2004; 117: 17-28. (* equal contribution) (* equal contribution) Ce — M­—M­— Research Report 2013 Science 62 63 from top left to bottom right Denise P. Barlow, Keiryn L. Bennett, Andreas Bergthaler, Christoph Binder, Christoph Bock, Kaan Boztug, Thijn Brummelkamp, Jacques Colinge, Sylvia Knapp, Robert Kralovics, Stefan Kubicek, Joanna I. Loizou, ­Sebastian Nijman, Giulio Superti-Furga 0 4,6904 4,8990 5,0990 6 6,1644 5,0990 4,6904 5,0990 4,4721 5,2915 4,8990 5,0990 6 5,2915 6,7823 6,4807 6,3246 6,6332 6,6332 5,8310 6,4807 6,4807 6,1644 4,2426 5,0990 4 3,7417 4,8990 5,0990 5,4772 4,6904 6,1644 4,4721 6,3246 6,3246 6,1644 5,8310 5,6569 6,3246 6,6332 6,3246 4,4721 4 4,6904 4,8990 4,8990 4,8990 5,2915 5,2915 5,0990 4,8990 5,6569 5,2915 5,0990 6 6,3246 7,4833 6,3246 6 6,4807 6,7823 6,4807 4,5826 5,1962 5 5,2915 5,2915 5,0990 5,6569 5,4772 6,9282 6,4807 6,6332 6,6332 6,4807 6,5574 5,7446 4,5826 5,6569 5,6569 5,6569 5,6569 5,4772 5,0990 5,4772 6,1644 6 6,4807 6,7823 5,3852 5,4772 5,0990 5,8310 6,1644 6,0000 5,5678 5,5678 5 4,6904 0 4,2426 4,2426 5,4772 5,6569 4,2426 4 4,2426 4,4721 4,6904 4,4721 4,4721 4,8990 4,8990 6 5,8310 5,4772 5,6569 6 5,0990 5,4772 6 5,4772 3,1623 4 4,4721 5,0990 4,8990 4,4721 4,4721 4,2426 5,0990 4 5,6569 5,6569 5,4772 5,0990 5,0990 5,2915 5,8310 5,6569 4,6904 4,4721 4,4721 4,8990 4,4721 4 4,2426 4,6904 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5,4772 5,6569 5,0990 5,2915 5,0990 5,1962 5 5 5,0990 4 3,7417 4,8990 5,2915 5,4772 4,2426 3,7417 4 4,4721 3,4641 3,1623 3,4641 4,2426 4,8990 5,2915 5,2915 4,8990 5,0990 5,4772 4,4721 4,6904 5,2915 4,8990 4 0 3,7417 4 4 2,8284 2,4495 4 4,2426 4,4721 4,8990 4,8990 4,6904 4 4 4,4721 5,0990 4,6904 5,0990 4,8990 3,7417 4,4721 4,6904 3,1623 4,4721 4,8990 3,7417 3,4641 3,1623 4,4721 4,8990 4,2426 5,2915 6,3246 4,8990 4,6904 5,2915 5,2915 5,2915 4,5826 5,1962 4,5826 5,0990 5,6569 4 3,7417 4,6904 6 5,2915 5,0990 5,6569 6 5,1962 5,7446 5 4,6904 4,6904 4,6904 3,1623 3,4641 4,6904 3,1623 4,8990 4,6904 5,4772 5,2915 3,8730 4,8990 5,0990 4,4721 4,6904 4,8990 4,5826 5 5 4 4,4721 4,4721 5,2915 5,6569 5,8310 4,6904 4,6904 5,0990 4,4721 4,6904 4,4721 4,2426 5,0990 5,2915 6 5,6569 5,8310 5,8310 6,1644 5,2915 5,8310 6 5,6569 4,4721 3,7417 0 3,1623 3,7417 3,7417 4 4,2426 5,0990 4,4721 5,6569 5,6569 5,0990 4,8990 4,8990 5,2915 5,8310 5,4772 5,0990 4,8990 4,6904 3,7417 3,4641 3,7417 5,2915 5,2915 4,2426 4 4,4721 5,0990 5,2915 5,2915 6 6,9282 5,8310 5,6569 5,8310 6 6 4,5826 5,5678 5 4,8990 4,6904 4,4721 4,6904 5,2915 6,3246 6,1644 6 6 6 5,9161 5,7446 5,3852 4,4721 4,4721 4,4721 4,6904 4,4721 4,6904 4,4721 5,8310 5,0990 5,8310 6 4,3589 4,2426 4 4,8990 5,6569 5,4772 4,5826 5,3852 5 3,7417 5,0990 4,2426 5,4772 5,8310 6 4,8990 4,4721 4,8990 3,4641 4 3,4641 4,2426 5,2915 5,0990 6,1644 5,8310 5,6569 6 6 5,0990 5,8310 5,8310 5,4772 5,0990 4 3,1623 0 3,7417 3,4641 4 4,2426 4,8990 4,2426 5,4772 5,4772 5,2915 4,8990 4,6904 5,4772 5,8310 5,4772 5,2915 5,0990 4,4721 4 4,4721 4 5,0990 5,0990 4,2426 3,4641 4,4721 4,8990 5,0990 5,2915 6,1644 6,9282 6 5,2915 6,1644 6,1644 5,8310 4,7958 5,3852 5,1962 4,8990 5,2915 4,6904 4,4721 5,0990 6,6332 6,3246 6 6,3246 6,1644 5,9161 5,9161 5,1962 4,8990 4,8990 4,8990 4,8990 5,0990 4,6904 4,6904 6 5,6569 6,1644 6,1644 4,5826 5,0990 4,6904 5,4772 5,8310 6 5,1962 5,5678 5,1962 4,8990 4,8990 4 5,6569 6 6,1644 5,0990 5,0990 5,2915 4,2426 4,2426 4,2426 4,8990 5,2915 6 6,3246 6,3246 6 6,1644 6,4807 5,6569 6 6,3246 6 4,8990 4 3,7417 3,7417 0 4 4 5,0990 4,8990 4,6904 6 6 5,8310 5,2915 5,2915 5,6569 6 5,8310 5,6569 5,4772 4,8990 4,6904 4,4721 4,6904 5,6569 5,8310 4 3,1623 4,2426 5,0990 5,8310 5,4772 6,3246 7,0711 6 5,8310 6 6,3246 6,1644 5,3852 5,5678 5,3852 5,2915 5,4772 5,2915 3,1623 5,2915 6,4807 6,1644 6,1644 6,1644 6,4807 6,0828 6,2450 6,0828 5,0990 4,8990 4,8990 4,6904 4,4721 4,8990 4,6904 5,8310 5,4772 6 6,1644 5 4,6904 4,8990 5,0990 5,8310 5,6569 5,1962 5,5678 5,5678 5,0990 4,4721 3,1623 5,0990 5,6569 5,6569 4,6904 4,2426 4,2426 4,4721 2,8284 3,1623 4 4,6904 4,6904 5,4772 5,2915 5,2915 5,4772 5,8310 4,8990 5,0990 5,6569 5,2915 4,4721 2,8284 3,7417 3,4641 4 0 2,8284 4 4,2426 4 5,2915 5,2915 4,6904 4,2426 4,4721 4,8990 5,4772 4,8990 5,0990 4,8990 4,2426 4,4721 4,6904 3,1623 4,8990 4,8990 4 3,4641 3,4641 4 4,8990 4,4721 5,6569 6,6332 5,2915 4,8990 5,4772 5,6569 5,6569 4,5826 5,1962 5 5,2915 5,6569 4 3,7417 4,2426 6,3246 5,6569 5,2915 6 6 5,5678 5,7446 5 5,0990 5,0990 5,0990 4 4,2426 5,0990 3,7417 5,2915 5,0990 5,8310 5,6569 3,8730 5,2915 5,0990 4,8990 5,0990 5,2915 4,5826 5,3852 5 5,4772 4,4721 3,7417 5,2915 5,6569 5,8310 4,6904 4,2426 4,4721 4,4721 3,4641 3,1623 3,4641 4,4721 5,2915 5,4772 5,6569 5,2915 5,4772 5,6569 4,8990 5,0990 5,6569 5,2915 4,4721 2,4495 4,0000 4 4 2,8284 0 4,2426 4 4,4721 5,2915 5,2915 5,0990 4,2426 4,4721 4,8990 5,4772 5,0990 5,4772 5,2915 4,2426 4,8990 5,0990 3,7417 4,4721 4,8990 4,2426 3,4641 2,8284 4,4721 5,2915 4,6904 5,2915 6,6332 5,2915 5,0990 5,6569 5,6569 5,6569 5,0000 5,1962 5 5,4772 6 4,4721 3,7417 4,6904 6,3246 5,6569 5,4772 6 6,1644 5,5678 5,9161 5,1962 5,0990 5,0990 5,0990 3,7417 4 5,0990 3,7417 5,2915 5,0990 5,8310 5,6569 4,3589 5,2915 5,4772 4,6904 5,0990 5,2915 5 5 5 4,6904 4,2426 4,4721 4,6904 5,8310 6 4,8990 3,7417 3,7417 4,2426 4,2426 4,2426 4 5,0990 4,2426 6,1644 5,8310 5,6569 6 6 5,0990 5,8310 5,8310 5,4772 4,2426 4 4,2426 4,2426 5,0990 4 4,2426 0 5,0990 3,1623 5,4772 5,4772 5,2915 4,8990 4,8990 5,4772 5,6569 5,4772 4,2426 4 4,2426 4,8990 5,0990 4 4,2426 3,1623 5,0990 4,8990 4,4721 4 3,7417 5,0990 5,4772 6,7823 5,6569 5,4772 6,1644 6,1644 5,6569 4,7958 5 5,1962 5,0990 5,0990 3,7417 4,8990 4,2426 6,4807 5,4772 6 6,1644 6 5,7446 5,7446 4,3589 5,6569 5,4772 5,4772 4,6904 4,8990 4,8990 4,6904 5,0990 5,6569 6,1644 6 4,3589 5,6569 5,4772 5,2915 5,0990 5,2915 5 4,5826 4,3589 6,1644 5,0990 4,6904 4,6904 5,6569 5,8310 3,4641 5,0990 5,4772 5,0990 4,4721 4,4721 4 2 4,6904 5,2915 5,4772 5,4772 5,2915 5,2915 3,7417 4,8990 5,2915 4,2426 5,2915 4,2426 5,0990 4,8990 4,8990 4,2426 4,0000 5,0990 0 4,8990 5,2915 5,2915 5,0990 3,1623 4,4721 3,7417 4,2426 4,6904 6 5,8310 4,6904 5,4772 5,4772 4,4721 5,0990 5,4772 4,6904 4,4721 4,4721 5,2915 5,0990 4,2426 5,4772 6,4807 5,8310 4,6904 5,2915 5,2915 5,0990 5,1962 5,5678 5 6 6,1644 4,8990 4,6904 5,2915 5,6569 5,4772 5,2915 5,2915 4,8990 5 5,9161 5,5678 5,4772 5,4772 5,6569 4,8990 4,8990 5,6569 4,8990 5,8310 5,8310 5,0990 4,8990 5 5,6569 6 5,0990 5,8310 6 5,5678 5,5678 5,5678 4,4721 4 4 4,6904 5,8310 6 4,6904 4,2426 4,2426 4 4,2426 4,2426 4,6904 5,2915 4,6904 6,4807 6 6 6,1644 6,1644 5,2915 6,1644 6,1644 5,6569 4,2426 4,4721 4,4721 4,2426 4,6904 4 4,4721 3,1623 4,8990 0 5,8310 5,8310 5,6569 5,2915 5,2915 5,6569 5,8310 5,8310 4,2426 4 4,4721 5,2915 4,8990 4,2426 4,4721 4 5,4772 4,6904 4,6904 3,7417 3,4641 5,4772 5,8310 7,0711 5,8310 5,8310 6,1644 6,4807 6 4,5826 4,3589 5 5,2915 4,8990 4 4,8990 3,7417 6,4807 5,6569 6,3246 6,1644 5,8310 6,0828 5,5678 4,5826 5,8310 5,6569 5,8310 5,0990 4,6904 5,0990 5,0990 5,2915 5,6569 6,1644 6,3246 4,7958 5,4772 5,4772 5,2915 5,2915 5,0990 5 4,3589 4,3589 6,3246 5,6569 5,4772 5,4772 4,4721 4,2426 4,8990 5,0990 5,4772 5,8310 5,2915 5,0990 4,8990 5,2915 5,4772 4,2426 4,4721 4,2426 4 4 5,0990 4,8990 6,0000 5,4772 5,8310 4,8990 5,6569 5,4772 6 5,2915 5,2915 5,4772 5,2915 5,8310 0 0 3,7417 4,8990 5,0990 5,4772 5,8310 5,2915 6,1644 6,1644 5,2915 5,8310 6 5,2915 5,6569 6,1644 5,4772 5,6569 5,4772 6,1644 5,6569 5,2915 4,8990 5,6569 6,1644 5,0990 5,8310 5,4772 5,6569 5,5678 5,9161 5,1962 6,4807 6,4807 5,6569 5,8310 6,4807 6,3246 6,6332 6,1644 6 6,4807 6,0828 6,4031 6,0828 5,8310 5,8310 5,8310 5,6569 5,8310 6 5,4772 6,6332 6,3246 5,8310 5,6569 5,7446 6,1644 6,3246 6,1644 6,1644 6,3246 5,9161 6,0828 5,9161 6,3246 5,6569 5,4772 5,4772 4,4721 4,2426 4,8990 5,0990 5,4772 5,8310 5,2915 5,0990 4,8990 5,2915 5,4772 4,2426 4,4721 4,2426 4 4 5,0990 4,8990 6 5,4772 5,8310 4,8990 5,6569 5,4772 6 5,2915 5,2915 5,4772 5,2915 5,8310 0 0 3,7417 4,8990 5,0990 5,4772 5,8310 5,2915 6,1644 6,1644 5,2915 5,8310 6 5,2915 5,6569 6,1644 5,4772 5,6569 5,4772 6,1644 5,6569 5,2915 4,8990 5,6569 6,1644 5,0990 5,8310 5,4772 5,6569 5,5678 5,9161 5,1962 6,4807 6,4807 5,6569 5,8310 6,4807 6,3246 6,6332 6,1644 6 6,4807 6,0828 6,4031 6,0828 5,8310 5,8310 5,8310 5,6569 5,8310 6 5,4772 6,6332 6,3246 5,8310 5,6569 5,7446 6,1644 6,3246 6,1644 6,1644 6,3246 5,9161 6,0828 5,9161 6,1644 5,4772 5,6569 5,6569 3,7417 4,6904 5,0990 5,4772 5,8310 6 5,4772 5,2915 5,0990 5,0990 5,2915 4,6904 4 4,2426 4,4721 4,8990 5,2915 4,8990 6,1644 5,6569 5,6569 4,6904 5,0990 5,2915 5,8310 4,6904 5,0990 5,2915 5,0990 5,6569 3,7417 3,7417 0 4,8990 5,0990 5,2915 5,8310 5,4772 6,1644 6 5,4772 5,4772 5,6569 4,6904 5,8310 6 5,2915 5,4772 5,2915 5,6569 5,4772 5,2915 3,7417 5,0990 6 5,2915 5,8310 5,2915 5,6569 5,3852 6,0828 5,3852 6 6,1644 5,0990 5,6569 6,0000 6,3246 6,4807 6,1644 6 6,3246 6,0828 6,2450 5,9161 5,6569 5,8310 5,8310 5,2915 5,6569 5,8310 5,2915 6,4807 6 5,8310 5,4772 5,1962 6,1644 6 6 6 6,1644 5,3852 6,2450 5,5678 5,8310 5,0990 4,6904 3,7417 5,2915 5,2915 3,4641 4,6904 4,8990 5,2915 4,4721 4,4721 3,4641 3,1623 3,7417 4,8990 5,4772 5,0990 5,2915 5,0990 3,7417 4,0000 5,0990 4,2426 5,0990 4 4,8990 4,8990 5,2915 4,2426 4,2426 4,8990 3,1623 5,2915 4,8990 4,8990 4,8990 0 3,7417 4 4,2426 3,7417 5,8310 5,6569 4,6904 5,4772 5,6569 4,4721 4,8990 5,4772 4,2426 4,8990 4,8990 5,6569 5,0990 2,8284 5,2915 6,1644 5,8310 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4,6904 3,7417 4,8990 5,0990 4,8990 5,6569 4,6904 5,0990 3,1623 5,0990 4,2426 2,8284 5,4772 4,4721 5,2915 5,4772 5,6569 4,8990 4,8990 5,4772 3,7417 5,6569 5,4772 5,4772 5,2915 4 3,7417 0 3,7417 4 6,3246 6,1644 5,0990 5,8310 5,8310 4,6904 5,4772 5,4772 4,8990 5,0990 5,2915 6,0000 5,4772 4,4721 5,8310 5,8310 4,6904 4,2426 3,7417 4 4,6904 5,3852 6,0828 5,1962 6,3246 6,4807 5,0990 5,4772 5,4772 4,8990 5,0990 4,6904 4,8990 4,8990 4,5826 6,5574 6,0828 4,8990 5,2915 5,4772 4,6904 4,6904 5,2915 4,4721 5,6569 4,8990 4,6904 4,4721 4,5826 5,4772 5,8310 5,0990 5,4772 5,6569 5,1962 6,0828 6,0828 6,6332 5,8310 5,6569 5,2915 5,4772 5,6569 4,2426 5,6569 6 6 5,4772 5,4772 5,0990 4,2426 5,2915 5,6569 5,4772 6,0000 5,2915 5,4772 3,7417 5,2915 4,2426 4,2426 6 5,0990 5,8310 5,8310 6 5,4772 5,4772 5,6569 4,2426 5,8310 5,8310 5,8310 5,8310 4,2426 4 3,7417 0 4,2426 6,4807 6,3246 5,2915 6,1644 6,1644 5,2915 5,8310 5,6569 5,4772 5,6569 5,6569 6,3246 5,6569 4,6904 6,3246 5,4772 5,4772 4,6904 4,8990 5,2915 3,4641 5,7446 6,4031 5,5678 6,6332 6,4807 5,6569 5,8310 5,8310 4,4721 4,2426 3,7417 3,1623 3,7417 3 6,0828 6,4031 5,4772 5,6569 5,8310 5,0990 5,0990 5,8310 5,0990 4,8990 5,4772 4,4721 4,2426 5 5,8310 6,1644 5,4772 5,2915 5,4772 5,1962 6,2450 6,2450 6,3246 5,6569 5,2915 4,8990 5,0990 4,8990 4,4721 5,0990 5,2915 5,8310 5,0990 5,0990 4,8990 4,6904 4,8990 4,8990 5,0990 5,6569 4,8990 5,0990 4,0000 4,6904 5,0990 4,4721 5,6569 4,6904 5,4772 5,4772 5,8310 4,8990 5,0990 5,4772 4,6904 5,8310 5,2915 5,2915 5,4772 3,7417 3,4641 4,0000 4,2426 0 6 6,1644 5,2915 5,8310 6 5,0990 5,4772 5,6569 5,0990 5,4772 5,4772 6,1644 5,8310 4,2426 6 6,1644 5,6569 4,2426 4,2426 4,2426 4,8990 5,5678 6,2450 5,5678 6,6332 6,4807 5,4772 5,6569 5,8310 5,2915 5,8310 4,4721 4,6904 5,4772 4,5826 6,7082 6,2450 5,2915 5,4772 5,4772 4,8990 5,0990 5,6569 4,6904 6 5,6569 4,4721 4,2426 4,7958 5,6569 5,8310 5,0990 5,8310 6 5,3852 6,2450 6,0828 4,4721 4,6904 4,8990 5,0990 6,1644 6,3246 5,2915 4,2426 4,6904 5,2915 5,0990 5,0990 5,0990 5,8310 5,0990 6,7823 6,4807 6,3246 6,6332 6,6332 5,8310 6,4807 6,4807 6,1644 4,2426 5,0990 5,0990 5,2915 5,6569 5,0990 5,4772 4,2426 6 4,2426 6,1644 6,1644 6,1644 5,8310 5,8310 6,3246 6,4807 6 0 2,4495 4 5,2915 5,0990 4,6904 4,4721 4,6904 5,6569 5,4772 5,2915 4,8990 4,6904 5,6569 6 7,2111 6,1644 6 6,3246 6,6332 6,1644 4,3589 4,7958 4,7958 6 5,6569 4,8990 5,6569 5,2915 6,7823 6,1644 6,4807 6,4807 6,3246 6,2450 5,3852 4,5826 6,3246 6 6 5,4772 5,2915 5,8310 5,4772 5,8310 6 6,3246 6,4807 5 5,8310 5,6569 5,4772 6 5,8310 5,3852 5 4,5826 4 4,4721 4,6904 4,8990 6 6,1644 5,0990 4,2426 4,6904 5,0990 4,8990 4,8990 4,8990 5,6569 4,8990 6,6332 6,3246 6,1644 6,4807 6,4807 5,6569 6,3246 6,3246 6 3,7417 4,8990 4,8990 5,0990 5,4772 4,8990 5,2915 4 5,8310 4 6,1644 6,1644 6 5,6569 5,6569 6,1644 6,3246 6,1644 2,4495 0 4 5,2915 5,0990 4,4721 4,2426 4,4721 5,4772 5,2915 5,0990 4,6904 4,4721 5,4772 5,8310 7,0711 6 5,8310 6,1644 6,4807 6 4,3589 4,7958 4,7958 5,8310 5,4772 4,6904 5,4772 5,0990 6,6332 6 6,3246 6,3246 6,1644 6,0828 5,3852 4,1231 6,1644 6 6 5,2915 5,0990 5,6569 5,2915 5,6569 5,8310 6,3246 6,4807 4,7958 5,8310 5,6569 5,2915 5,8310 5,6569 5,1962 5 4,1231 4,6904 4,4721 4 5,0990 5,4772 5,6569 4,2426 4 4,4721 4,4721 3,7417 3,7417 3,7417 4,4721 5,0990 5,8310 5,6569 5,2915 5,4772 5,4772 4,4721 5,4772 5,4772 4,8990 4,2426 3,7417 4,6904 4,4721 4,8990 4,2426 4,2426 4,2426 4,6904 4,4721 5,2915 5,2915 5,4772 4,6904 4,6904 5,0990 5,2915 5,2915 4 4 0 4,6904 4,6904 3,4641 4,2426 4,4721 4,4721 4 4 4,8990 4,4721 4,6904 5,6569 6,3246 5,2915 4,8990 5,6569 5,6569 5,0990 3,6056 4,3589 3,6056 5,6569 5,6569 4,4721 4,4721 5,0990 6,1644 5,6569 5,6569 5,8310 5,8310 5,3852 4,5826 4,3589 5,0990 4,8990 5,0990 4,2426 4,2426 5,0990 4,2426 5,2915 5,2915 5,8310 5,6569 4,3589 5,0990 5,4772 4,8990 5,2915 5,4772 5 4,7958 5 4,8990 4,8990 5,0990 6 6,3246 6,4807 5,4772 4,8990 5,2915 4,8990 4,8990 4,6904 4,8990 5,2915 5,6569 6,3246 6 5,8310 6,1644 6,4807 5,6569 5,8310 6,3246 6 5,4772 4,4721 3,7417 4 4,6904 4,4721 4,8990 4,8990 5,4772 5,2915 5,8310 5,8310 5,4772 5,4772 5,2915 5,8310 6,1644 5,8310 5,2915 5,2915 4,6904 0 2,4495 4 5,4772 5,2915 4,4721 4,2426 4,2426 4,6904 4,8990 5,4772 6,1644 6,6332 6 5,6569 6,3246 6 6 5,3852 6,0828 5,5678 5,0990 4,6904 4,8990 4,8990 5,4772 6,7823 6,3246 6,3246 6,4807 6,4807 6,0828 6,0828 5,3852 4,4721 4 3,7417 4,8990 5,0990 4,6904 4,8990 6 5,8310 6 6 4,5826 4 3,7417 5,4772 5,8310 6 5 5,7446 5,3852 4,8990 4,4721 4,8990 5,8310 6,1644 6,3246 5,0990 5,0990 5,4772 4,8990 5,0990 5,0990 5,0990 5,2915 5,8310 6,4807 6 6 6,1644 6,4807 5,6569 6 6,4807 6 5,2915 4,6904 3,4641 4,4721 4,4721 4,6904 5,0990 5,0990 5,4772 4,8990 6 6 5,6569 5,6569 5,6569 5,8310 6,1644 6 5,0990 5,0990 4,6904 2,4495 0 4 5,4772 5,2915 4,6904 4,2426 4,4721 4,8990 4,8990 5,6569 6,3246 6,7823 6 6 6,1644 6,1644 6,1644 5 5,7446 5,1962 5,0990 4,4721 4,8990 5,0990 5,4772 6,6332 6,3246 6,4807 6,3246 6,1644 6,2450 5,7446 5,3852 4,4721 3,7417 4,2426 5,0990 4,6904 4,6904 5,0990 6 5,6569 6 6,1644 4,7958 3,7417 3,4641 5,2915 5,8310 5,6569 4,7958 5,3852 5,1962 4,8990 4 4,2426 5,0990 5,4772 5,6569 4,2426 4 4,4721 4,4721 4 3,7417 3,7417 4,2426 4,6904 5,4772 4,8990 5,2915 5,0990 5,4772 4,4721 5,2915 5,4772 4,8990 4,4721 3,1623 3,7417 4 4,6904 3,1623 3,7417 4 4,4721 4,2426 5,2915 5,2915 4,6904 4,4721 4,4721 4,6904 5,2915 5,0990 4,6904 4,4721 3,4641 4 4 0 3,7417 4,2426 4 3,4641 3,7417 4,2426 4,2426 4,4721 5,2915 6,3246 4,8990 4,8990 5,4772 5,2915 5,2915 4,1231 4,7958 4,5826 4,6904 4,8990 2,8284 4,2426 4,4721 6,1644 5,4772 5,4772 5,8310 5,6569 5,3852 5 4,5826 4,2426 4,6904 4,8990 4 4 4,6904 3,7417 5,0990 4,8990 5,6569 5,4772 3,6056 4,8990 4,8990 4,6904 4,8990 5,0990 4,3589 4,5826 4,7958 5,2915 4,2426 4,8990 4,6904 5,8310 6 4,6904 4 4,2426 4,4721 4,6904 4,4721 4 4,8990 4,6904 6 6 5,6569 5,8310 5,6569 4,8990 5,8310 6 5,2915 4,6904 4,4721 5,2915 5,0990 5,6569 4,8990 4,4721 4,2426 5,0990 4,4721 5,6569 5,6569 5,8310 4,8990 5,0990 5,4772 5,8310 5,4772 4,4721 4,2426 4,2426 5,4772 5,4772 3,7417 0 4 4,8990 4,6904 4,8990 4,8990 4,2426 4,8990 4,8990 6,7823 5,2915 5,2915 6 6 5,8310 5 4,5826 5 5,2915 5,2915 3,7417 5,2915 5,0990 6,6332 5,4772 6,1644 6,3246 6,1644 6,0828 5,5678 4,5826 5,0990 5,6569 5,8310 5,0990 5,0990 5,0990 4,8990 5,2915 5,8310 6,3246 6,1644 5,1962 5,8310 6,1644 5,4772 5,2915 5,4772 5,7446 4,1231 4,5826 5,2915 4,6904 5,0990 5,2915 5,8310 6 5,2915 4,4721 4,4721 4,6904 4,8990 4,8990 4,6904 5,2915 4,8990 6 5,6569 6,1644 5,8310 5,6569 4,6904 6,3246 5,6569 5,0990 5,0990 4,8990 5,2915 5,0990 5,8310 4,8990 4,8990 3,1623 5,4772 4 6,1644 6,1644 6 5,4772 5,0990 5,4772 5,6569 5,6569 4,6904 4,4721 4,4721 5,2915 5,2915 4,2426 4 0 5,4772 5,0990 5,0990 4,4721 4 5,4772 5,4772 6,4807 5,2915 5,0990 6 6 5,4772 5,1962 5,3852 5,5678 5,4772 5,4772 4,2426 5,4772 3,7417 6,3246 5,2915 6 6,1644 5,6569 5,7446 5,9161 4,5826 5,4772 5,0990 5,2915 4,4721 4,4721 4,4721 4,4721 4,6904 5,4772 6,1644 6 4,3589 5,2915 5,2915 5,0990 4,6904 4,8990 5 4,5826 4,5826 5,0990 4,8990 4,4721 4,8990 5,6569 5,6569 4,4721 4,6904 4,6904 4,4721 4,2426 4,2426 4,0000 4,4721 4,8990 5,4772 5,6569 5,2915 5,4772 5,8310 4,6904 4,8990 5,8310 5,0990 5,0990 3,7417 4,2426 4,2426 4 4 4,2426 5,0990 4,6904 5,4772 5,4772 5,4772 5,2915 4,2426 4,4721 4,8990 5,4772 5,0990 5,6569 5,4772 4,4721 4,4721 4,6904 4 4,8990 5,4772 0 2,8284 4,2426 5,0990 4,6904 4 5,4772 6,4807 5,2915 4,6904 5,0990 5,4772 5,6569 4,7958 5,7446 4,5826 5,0990 5,6569 4,6904 4,4721 5,4772 6,1644 5,4772 5,6569 5,8310 6,1644 5,7446 6,2450 5,7446 4,6904 4,8990 4,8990 4,4721 4,6904 4,6904 4,2426 5,6569 5,4772 5,6569 5,4772 4,7958 5,0990 5,2915 5,2915 5,4772 5,6569 5,3852 5,7446 5,5678 4,8990 4,4721 4 5,4772 5,8310 6 4,6904 4,4721 4,6904 3,4641 3,7417 3,4641 4,2426 4,6904 5,4772 5,8310 5,6569 5,4772 5,4772 5,8310 4,8990 5,4772 5,8310 5,2915 4,8990 3,4641 4 3,4641 3,1623 3,4641 3,4641 4,8990 4,4721 4,6904 5,6569 5,6569 5,4772 4,8990 4,8990 5,0990 5,6569 5,4772 5,4772 5,2915 4 4,2426 4,2426 3,4641 4,6904 5,0990 2,8284 0 3,4641 4,4721 5,0990 4,6904 5,6569 6,6332 5,0990 5,0990 5,6569 5,6569 5,6569 5,0000 5,1962 5 4,8990 5,4772 4,4721 3,7417 4,6904 6,4807 5,6569 5,6569 6,1644 6,3246 5,7446 6,0828 5,3852 4,4721 4,4721 4,6904 4,2426 4,2426 4,2426 4 5,2915 5,2915 6 5,8310 4,5826 4,6904 5,0990 5,0990 5,0990 5,2915 5,1962 5,3852 5,5678 5,6569 4,2426 3,7417 5,4772 5,8310 6 4,8990 4,4721 4,6904 4,6904 3,4641 3,4641 4 4,6904 5,4772 5,8310 5,8310 5,0990 5,6569 6 5,0990 4,8990 5,8310 5,4772 4,8990 3,1623 4,4721 4,4721 4,2426 3,4641 2,8284 4,4721 4,4721 4,6904 5,4772 5,4772 5,2915 4,8990 4,8990 5,2915 5,6569 5,4772 5,2915 5,0990 4 4,2426 4,4721 3,7417 4,8990 5,0990 4,2426 3,4641 0 3,7417 4,6904 4,6904 5,6569 6,1644 5,2915 5,0990 5,6569 5,4772 5,4772 5,1962 5,1962 5 5,0990 5,8310 4,6904 3,7417 4,6904 6,3246 5,6569 5,6569 6 6,3246 5,5678 5,9161 5,1962 5,0990 4,8990 4,8990 3,4641 3,7417 5,0990 4 5,2915 5,2915 5,8310 5,6569 4,3589 5,0990 5,2915 4,8990 5,0990 5,2915 4,7958 5,1962 5,1962 5,2915 4,2426 4,6904 5,4772 6,4807 6,6332 5,6569 4,6904 4,2426 4,6904 4,4721 4,2426 5,0990 5,4772 5,0990 6,4807 6,1644 5,6569 6,3246 6,6332 5,8310 5,8310 6,3246 6,1644 4,6904 4,4721 5,0990 4,8990 5,0990 4 4,4721 4 5,2915 3,7417 6,1644 6,1644 5,6569 5,6569 5,6569 6 6,3246 6,1644 4,8990 4,6904 4,8990 4,6904 4,8990 4,2426 4,8990 4,4721 5,0990 4,4721 3,7417 0 3,7417 5,2915 5,6569 6,7823 5,6569 5,8310 6,3246 6,1644 6,1644 5,5678 5,1962 5,7446 5,0990 5,4772 4,2426 4,6904 3,1623 6,7823 5,4772 6,3246 6,4807 6,6332 6,2450 6,2450 4,7958 5,8310 5,6569 5,6569 4,8990 5,0990 5,0990 4,6904 5,0990 6 6,4807 6,3246 4,7958 5,8310 5,6569 5,6569 4,8990 5,0990 5,1962 5,1962 5 5,0990 4,2426 5,0990 4,6904 6 6,1644 4,6904 4,4721 4,4721 4,6904 4,8990 4,8990 4,4721 4,8990 4,2426 6,3246 5,8310 5,4772 6 6 4,8990 5,4772 6,1644 5,2915 5,0990 4,8990 5,2915 5,0990 5,8310 4,8990 5,2915 3,7417 5,0990 3,4641 5,6569 5,6569 5,4772 5,0990 5,0990 5,4772 5,6569 5,8310 4,6904 4,4721 4,4721 4,8990 4,8990 4,2426 4,2426 4 4,6904 5,0990 4,6904 3,7417 0 4,8990 5,4772 6,4807 5,6569 5,2915 6 6 5,8310 4,5826 5 4,5826 5,0990 5,0990 4 5,4772 4,4721 6,4807 5,2915 6,3246 6,1644 5,8310 6,0828 5,7446 4,3589 5,6569 5,6569 5,8310 5,2915 5,2915 5,0990 5,2915 5,4772 6,1644 6,1644 6 5 5,8310 5,8310 5,8310 5,2915 5,4772 5,3852 4,7958 4,5826 6 5,0990 4,6904 3,7417 5,4772 5,4772 3,7417 4,8990 4,6904 5,2915 4,4721 4,4721 4,2426 4 3,7417 5,4772 5,6569 5,0990 5,4772 5,6569 4 4 5,2915 4,4721 5,2915 4,2426 5,2915 5,2915 5,4772 4,4721 4,6904 5,0990 4,2426 5,4772 5,2915 5,2915 5,2915 2,8284 4,2426 4,4721 4,6904 4,2426 5,6569 5,4772 4,6904 5,4772 5,6569 4,4721 4,8990 5,4772 4 4,6904 4,6904 5,2915 4,8990 0 5,2915 6,1644 5,6569 4 4 5,0990 5,0990 5,1962 5,7446 5 6 6 4,8990 5,0990 5,6569 5,4772 5,6569 4,8990 5,0990 5,6569 5 6,4031 5,7446 5,6569 5,8310 5,8310 4,8990 5,0990 5,6569 4,6904 5,8310 5,8310 5,2915 5,0990 5,1962 6 6,1644 5,6569 5,6569 5,8310 5,7446 5,7446 5,7446 6,3246 5,2915 6 5,0990 4,2426 5,0990 5,4772 5,2915 5,4772 5,8310 5,8310 5,6569 5,2915 5,2915 5,0990 4,8990 4,8990 4,8990 4,8990 5,0990 5,6569 5,4772 6,4807 6 5,4772 5,2915 6 6,1644 6,3246 5,6569 5,2915 5,4772 5,4772 5,8310 4,8990 4,8990 3,7417 5,2915 5,6569 5,8310 6,3246 6 6 5,8310 5,6569 6,1644 6,3246 5,2915 4,8990 5,4772 5,4772 5,6569 5,6569 5,6569 5,4772 5,2915 0 5,4772 5,8310 5,4772 6 5,8310 5,8310 6,0828 6,2450 6,0828 6,4807 6,6332 5,2915 6 6 6,6332 6,1644 6,4807 6,3246 6,7823 6,4031 7 5,7446 6,3246 6,4807 6,4807 5,6569 6 6 5,6569 6,1644 6,3246 6,1644 5,8310 5,9161 6,6332 6,7823 6,1644 6,1644 6,3246 6,4031 5,9161 5,5678 7,4833 6,6332 6,6332 6,7823 4,8990 5,4772 6,3246 6,6332 6,9282 7,0711 6,4807 6,4807 6,3246 6,3246 6,7823 5,6569 5,4772 5,4772 5,4772 5,6569 5,8310 5,8310 4,8990 5,6569 7,0711 6,3246 6,9282 6,9282 7,0711 6,6332 6,6332 6,7823 6,4807 7,0711 5,6569 5,6569 5,0990 6,1644 5,8310 5,8310 5,4772 6,1644 7,2111 7,0711 6,3246 6,6332 6,7823 6,3246 6,7823 6,4807 6,4807 6,6332 6,1644 6,7823 6,4807 6,1644 5,4772 0 5,8310 5,6569 5,6569 5,6569 5,2915 6,8557 7,2801 6,7082 7,4833 7,3485 6,7823 6,7823 6,7823 4,4721 6,3246 5,6569 5,4772 6,3246 5,5678 7,1414 7,1414 6,6332 6,4807 6,4807 6 6,1644 6,6332 6 6,1644 5,4772 6,1644 6 6,2450 6,6332 6,7823 6,6332 6,3246 6,4807 6,2450 7,1414 7 6,3246 5,2915 5,6569 6 5,6569 5,8310 5,6569 5,2915 5,4772 5,6569 5,4772 5,2915 5,2915 5,6569 6 5,6569 5,4772 6 5,2915 5,6569 5,2915 6,0000 5,4772 5,0990 5,6569 4,8990 5,8310 6 6 5,2915 5,2915 5,6569 5,8310 5,8310 6,1644 6,1644 6 5,8310 5,0990 4,6904 5,4772 5,6569 6,1644 6 5,2915 6 6 4,8990 5,2915 5,2915 5,2915 5,0990 5,2915 5,6569 5,6569 5,6569 5,8310 5,8310 0 5,4772 5,2915 5,2915 5,6569 5,7446 6,0828 5,9161 6,1644 6,4807 5,0990 5,6569 5,2915 6 5,0990 5,6569 6 6,1644 5,7446 6,7082 6,0828 5,0990 5,6569 5,8310 4,8990 4,8990 5,2915 4,6904 5,0990 5,2915 5,8310 5,6569 5 5,8310 6,1644 5,4772 5,2915 5,4772 5,1962 6,0828 6,2450 6 5,6569 4,8990 4,6904 4,6904 4,8990 4 5,0990 5,2915 5,6569 4,6904 4,4721 4,4721 4,4721 4,6904 5,0990 5,0990 4,8990 4,8990 4,8990 3,1623 4,2426 4,6904 3,7417 5,8310 4,6904 5,6569 5,2915 5,8310 4,8990 5,0990 5,4772 4,6904 5,8310 5,0990 5,0990 5,2915 4,2426 3,7417 4,2426 4,6904 4,2426 6 5,8310 4,8990 5,6569 6 4,8990 5,2915 5,0990 4,6904 5,0990 5,0990 5,8310 5,2915 4 5,4772 5,6569 5,4772 0 3,7417 4,2426 4,2426 5,3852 6,0828 5,1962 6,4807 6,6332 5,4772 5,4772 5,4772 4,6904 5,6569 4,6904 4,4721 5,2915 5 6,5574 6,0828 5,4772 5,4772 5,4772 4,4721 4,6904 5,4772 4,2426 5,6569 5,4772 4,2426 4,2426 5 5,6569 5,6569 5,4772 5,4772 5,6569 5,5678 6,0828 5,9161 6,4807 5,8310 5,2915 4,8990 4,8990 4,8990 4,4721 5,8310 5,8310 6,3246 5,4772 5,4772 5,2915 5,0990 5,2915 5,2915 5,4772 5,6569 5,2915 5,4772 4,4721 4,4721 5,0990 4,2426 6 5,2915 5,8310 6,1644 6 5,4772 5,6569 6,1644 5,2915 6,1644 5,8310 5,8310 5,8310 4,4721 4,2426 3,7417 4,8990 4,2426 6,3246 6,1644 5,6569 6,3246 6,1644 5,4772 6 6 5,0990 5,6569 5,6569 6,3246 6 4 6 5,6569 5,2915 3,7417 0 4 4,8990 5,7446 6,4031 5,5678 6,9282 6,6332 6 6 6,1644 4,2426 6 5,0990 4,2426 5,4772 5,1962 6,8557 6,7082 5,8310 6,1644 6,1644 5,2915 5,0990 6,1644 5,0990 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6,4807 5,6569 5,8310 4,6904 4,6904 4,8990 5,9161 6,1644 6,3246 6 6,1644 6 5,7446 6,7082 6,5574 6,4807 5,2915 5,8310 5,6569 6,1644 6,3246 5,4772 5,4772 5,2915 5,8310 5,6569 5,4772 5,4772 5,2915 5,6569 6,1644 6 6,3246 5,8310 6,1644 5,0990 6,3246 5,4772 5,4772 5,6569 5,2915 6,1644 6,3246 6,1644 5,6569 5,6569 5,4772 5,4772 5,6569 6,6332 6,6332 6,4807 5,8310 5,0990 5,0990 4,2426 5,8310 6,1644 6 5,6569 6,3246 6,3246 5,4772 5,4772 5,2915 5,4772 5,6569 5,6569 5,4772 5,2915 5,6569 6,1644 6,3246 5,0990 5,6569 6 6,1644 4,8990 5,9161 6,0828 5,7446 6 6,3246 5,0990 5,6569 4,6904 5,6569 0 4,8990 4,8990 4,8990 4,5826 6,4031 6,0828 5,6569 5,8310 6 5,0990 5,0990 5,4772 4,8990 2,8284 5,6569 5,6569 5,4772 5,1962 6 6,3246 5,6569 4,4721 4,6904 5,3852 6,0828 6,0828 6,6332 6 5,4772 5,6569 5,6569 5,6569 4,8990 5,4772 5,8310 6,1644 5,2915 5,2915 5,4772 5,0990 5,6569 5,6569 5,6569 6 5,4772 5,6569 4,4721 5,4772 4 4,8990 6,1644 5,0990 6 6 6,1644 5,2915 5,4772 6 5,2915 6,3246 6,1644 6,1644 6,1644 4,8990 4,6904 4,6904 3,7417 4,4721 6,4807 6,3246 5,6569 6,3246 6,4807 5,4772 6,1644 6 5,6569 5,6569 5,6569 6,3246 6,3246 4,8990 6,4807 5,6569 5,6569 4,6904 5,0990 5,2915 4 5,9161 6,5574 5,9161 6,7823 6,7823 5,8310 5,6569 5,8310 4,6904 4,8990 0 4,2426 4,6904 3 6,7082 6,5574 5,8310 6 6 5,0990 5,2915 6 4,8990 5,2915 5,2915 5,0990 4,8990 5 6,1644 6,3246 5,0990 5,4772 5,6569 5,3852 6,5574 6,4031 6,6332 6 5,6569 5,2915 5,0990 5,2915 4,6904 6 6,3246 6,4807 5,8310 5,8310 5,4772 5,0990 5,6569 5,6569 5,6569 6 5,4772 5,6569 4,6904 5,0990 4,6904 5,0990 6 5,6569 6 6,3246 6,1644 6 6 6,1644 5,2915 6,1644 6 6 6 4,8990 4,4721 4,8990 3,1623 4,6904 6,4807 6,3246 5,8310 6,4807 6,3246 5,8310 6,3246 6,1644 5,8310 6,1644 6 6,4807 6,1644 5,0990 6,3246 5,4772 6 4,4721 4,2426 5,0990 3,7417 5,7446 6,4031 5,5678 6,9282 6,4807 6 6 6,1644 3,1623 4,8990 4,2426 0 4 3,6056 6,2450 6,8557 6 6,1644 6,1644 5,4772 5,2915 6,3246 5,4772 5,4772 5,4772 3,7417 4 5,3852 6 6,1644 5,4772 5,8310 5,6569 5,1962 6,4031 6,2450 6,4807 6,1644 5,8310 5,4772 5,6569 5,8310 4,4721 6,1644 6,4807 6,4807 6 6 5,2915 4,6904 5,4772 6 5,8310 6,4807 6 5,6569 4,4721 6,1644 4,8990 4,8990 6,4807 6 6 6,1644 6,4807 6 6,1644 6 4,8990 5,8310 6,4807 6,4807 6,3246 5,0990 5,2915 4,8990 3,7417 5,4772 6,3246 6,1644 5,8310 6,4807 6,1644 5,6569 6,1644 5,6569 6,1644 6,3246 6,3246 6,6332 5,8310 5,6569 6,7823 6,3246 6,1644 5,2915 5,4772 6 4 5,3852 6,4031 5,5678 6,6332 6,3246 5,8310 6 6 4,8990 4,8990 4,6904 4 0 4,1231 5,5678 6,2450 6,1644 6,3246 6,4807 5,8310 5,4772 6,4807 5,8310 5,6569 5,8310 5,0990 5,2915 5,3852 6,1644 6,1644 4,8990 6 5,8310 5,1962 6,0828 5,9161 6,5574 5,9161 5,5678 5,5678 5,5678 5,7446 4,7958 5,3852 5,9161 6,0828 5,3852 5,3852 5,3852 4,7958 5,5678 5,7446 5,7446 6,0828 5,5678 5,7446 4,3589 5,5678 4,1231 4,7958 6,0828 5,1962 5,9161 5,9161 6,0828 5,5678 5,5678 5,7446 5 6,0828 6,0828 6,0828 6,0828 4,7958 4,5826 4,5826 3 4,5826 6,2450 6,0828 5,3852 6,0828 6,2450 5,3852 6,0828 5,7446 5,7446 5,7446 5,5678 6,2450 6,0828 5 6,4031 5,5678 5,7446 5 5,1962 5,3852 3,3166 5,6569 6,3246 5,6569 6,7082 6,5574 5,7446 5,5678 5,7446 4,5826 4,5826 3 3,6056 4,1231 0 6,1644 6,3246 5,7446 5,7446 5,7446 5 5,1962 5,9161 5 5 5,3852 5 4,7958 4,2426 5,9161 6,0828 5,1962 5,3852 5,5678 4,6904 6,1644 6 5,7446 5,7446 5,5678 6,2450 6,5574 6,7082 5,5678 5,9161 6,2450 6,2450 5,7446 5,7446 5,1962 5,7446 6,2450 6,8557 6,7082 6,5574 6,8557 6,5574 6,0828 6,7082 6,5574 6,4031 5,7446 5,7446 5,7446 5,9161 6,2450 5,7446 5,9161 5,7446 5,9161 5,5678 6,4031 6,4031 6,2450 5,9161 6,2450 6,5574 6,0828 6,7082 5,3852 5,3852 4,5826 6,0828 5,7446 5 5,5678 5,9161 6,2450 6,0828 5,9161 6,2450 5,7446 6,4031 7 7,1414 6,7082 6,5574 6,8557 6,8557 6,2450 4,2426 4,6904 4,4721 6,0828 5,7446 5,3852 6,2450 6,4031 6,7082 6,4031 6,7082 6,2450 5,5678 6,1644 0 4,8990 5,5678 6,0828 6,2450 5,9161 5,5678 6,2450 5,9161 6,0828 5,5678 6,7082 6,8557 5,4772 6,2450 6,2450 5,9161 5,5678 5,3852 5,4772 5,2915 5,4772 4,5826 4,3589 5,3852 5,1962 6,4031 6,5574 5,3852 4,5826 4,7958 5 5,1962 5 4,5826 5,3852 4,7958 6,4031 6,2450 5,9161 6,4031 6,0828 5,5678 6,0828 6,4031 5,9161 4,3589 5 5,3852 5,1962 6,0828 5 5,1962 4,3589 5,5678 4,5826 6,0828 6,0828 5,9161 5,3852 5,7446 6,0828 6,4031 6,2450 4,5826 4,1231 4,3589 5,3852 5,3852 4,5826 4,5826 4,5826 5,7446 5,3852 5,1962 4,7958 4,3589 5,7446 5,7446 7,1414 6,0828 6,0828 6,7082 6,5574 6,4031 4,4721 4,6904 4,6904 5,7446 5,7446 4,5826 5,7446 5,1962 7,1414 6,0828 6,5574 6,8557 6,2450 6,3246 4,8990 0 5,7446 5,7446 5,9161 5,3852 5,3852 5,1962 5,1962 5,5678 6,0828 6,7082 6,5574 4,8990 6,0828 6,0828 5,7446 5,5678 5,7446 5,4772 4,8990 4,6904 5,6569 5,0990 5,4772 6 5,6569 5,8310 5,2915 5,2915 5,6569 4,8990 5,2915 5,0990 4,8990 5,2915 6 5,6569 5,4772 6 5,2915 5,6569 4,8990 6 6 5,2915 5,6569 4,6904 4,4721 4,8990 5,0990 5,0990 5,0990 5,6569 5,4772 5,8310 5,8310 5,8310 5,6569 5,4772 4,6904 4,8990 5,4772 5,2915 6,3246 6,1644 5,0990 4,4721 4,4721 4,2426 5,0990 5,4772 4,6904 4,4721 5,0990 5,8310 5,6569 5,6569 6,3246 6,6332 5,0990 5,4772 5,8310 5,2915 5,8310 5,3852 5,3852 5,1962 4,8990 4,6904 4,6904 5,2915 5,4772 6,4807 5,6569 5,8310 6 6,1644 5,7446 5,5678 5,7446 0 3,1623 3,4641 4,4721 4,4721 3,4641 4,2426 5,4772 5,2915 5,6569 5,4772 4,3589 4 4,4721 5,0990 5,0990 5,2915 4,7958 5,5678 6,0828 5,6569 5,0990 5,2915 6,1644 6 6,1644 5,4772 5,0990 5,4772 4,8990 5,0990 5,0990 5,0990 5,2915 6,1644 6 5,8310 6,1644 5,6569 6 4,8990 6,1644 5,8310 5,2915 5,6569 4,6904 4,4721 4,8990 4,8990 5,0990 5,0990 5,4772 5,4772 5,6569 5,8310 5,8310 5,8310 5,6569 5,0990 5,2915 5,6569 5,4772 6 6 4,8990 4 3,7417 4,6904 5,6569 5,0990 4,8990 4,4721 4,8990 5,6569 5,6569 5,8310 6,4807 6,4807 5,6569 5,4772 6,1644 5,6569 5,8310 5,7446 5,9161 5,3852 5,2915 5,0990 5,2915 5,0990 5,0990 6,3246 5,8310 6 6,1644 6,3246 5,7446 6,0828 5,7446 3,1623 0 2 4 4 3,1623 4 5,0990 5,0990 5,6569 5,4772 4,3589 3,1623 3,4641 5,0990 4,8990 5,0990 4,7958 5,7446 5,9161 5,6569 5,2915 5,2915 6,1644 6 6,1644 5,6569 5,0990 5,4772 5,0990 5,0990 5,0990 5,0990 5,4772 6,1644 6 6 6,1644 5,8310 6,1644 5,0990 6,1644 5,8310 5,4772 5,6569 4,6904 4,4721 4,8990 4,8990 5,0990 5,0990 5,4772 5,6569 5,8310 5,8310 5,8310 5,8310 5,6569 5,0990 5,4772 5,8310 5,4772 6 6 5,0990 3,7417 4,2426 4,8990 5,8310 5,2915 4,8990 4,6904 4,8990 5,6569 5,8310 5,8310 6,4807 6,4807 5,8310 5,4772 6,1644 5,6569 5,8310 5,9161 6,0828 5,5678 5,4772 5,0990 5,4772 5,0990 5,2915 6,3246 6 6 6,1644 6,4807 5,7446 6,2450 5,9161 3,4641 2 0 4 4,2426 3,4641 4 5,2915 5,0990 5,6569 5,4772 4,3589 3,1623 3,7417 5,0990 5,0990 5,2915 4,7958 5,9161 5,9161 5,6569 4,6904 4,2426 5,4772 5,0990 5,4772 4,8990 4,4721 4,6904 5,0990 4 4 4,2426 4,6904 5,4772 5,2915 5,2915 5,4772 5,0990 5,4772 4,2426 5,2915 5,0990 4,6904 4,8990 3,1623 4,6904 4,8990 4,6904 4 3,7417 4,6904 4,8990 5,0990 5,6569 5,6569 5,2915 4,8990 4,2426 4,6904 5,0990 4,8990 5,4772 5,2915 4,2426 4,8990 5,0990 4 5,0990 4,4721 4,4721 4,2426 3,4641 4,8990 5,2915 4,8990 5,6569 6 4,8990 4,4721 5,2915 5,2915 4,8990 5,1962 5,7446 5,1962 5,2915 6 4,6904 4,2426 4,2426 5,6569 5,0990 5,0990 5,4772 5,8310 5 5,9161 5,3852 4,4721 4 4 0 2 4,2426 2,4495 4,2426 4 5,0990 4,6904 3,3166 4,4721 4,6904 4,2426 4,4721 4,6904 4,3589 5,3852 5,1962 5,4772 4,2426 4,0000 5,2915 5,0990 5,2915 4,4721 4,6904 4,8990 5,0990 4,2426 4,2426 4,4721 4,6904 5,6569 5,4772 5,2915 5,6569 5,0990 5,4772 4,2426 5,4772 5,2915 4,6904 4,6904 3,4641 4,4721 5,0990 4,4721 4,2426 4 4,8990 4,8990 4,6904 5,8310 5,8310 5,6569 5,0990 4,4721 4,6904 5,0990 5,0990 5,2915 5,0990 4,2426 5,0990 4,6904 4 5,0990 4,4721 4,6904 4,2426 3,7417 5,0990 5,2915 5,0990 6 6,1644 4,8990 4,6904 5,0990 5,4772 5,2915 4,7958 5,3852 4,7958 5,2915 5,6569 4,6904 4,4721 4,2426 5,4772 5,0990 5,2915 5,2915 5,4772 5,1962 5,5678 5,3852 4,4721 4 4,2426 2 0 4,2426 2,8284 4,2426 4 4,8990 5,0990 3,6056 4 4,4721 4 4,4721 4,2426 4,1231 5 5,1962 5,0990 4,4721 5,4772 5,6569 6 6,1644 5,4772 4,8990 4,8990 3,7417 5,2915 5,0990 5,0990 5,4772 5,6569 6 5,8310 6,1644 5,6569 6 4,8990 6,1644 5,8310 5,2915 5,0990 4,6904 4,6904 4,6904 4,8990 5,0990 5,0990 4,8990 5,6569 5,0990 6 6 5,8310 5,6569 5,0990 5,2915 5,8310 5,6569 5,8310 5,6569 5,0990 4,6904 4,6904 4,6904 5,0990 4,4721 4,6904 4,2426 5,0990 5,0990 5,0990 5,6569 6 6,6332 5,2915 5,4772 6,1644 5,6569 6 5,7446 5,1962 5,3852 4,4721 4,6904 4,4721 5,2915 4,4721 6,4807 5,4772 6 6,3246 6,4807 5,9161 6,2450 5,1962 3,4641 3,1623 3,4641 4,2426 4,2426 0 4 4,6904 5,0990 6 5,8310 4,5826 4 4,4721 5,2915 4 4,2426 5 5,1962 5,7446 5,4772 4,4721 4,2426 5,2915 5,0990 5,2915 4,6904 4,2426 4,2426 4,8990 4,0000 3,4641 4 4,6904 5,2915 5,0990 5,0990 5,0990 4,8990 5,2915 4 5,2915 4,8990 4,4721 4,6904 3,1623 4,4721 4,6904 4,6904 3,7417 3,7417 4,6904 4,8990 5,0990 5,4772 5,4772 5,2915 4,6904 4 4,4721 5,0990 4,6904 5,4772 5,2915 4,2426 4,8990 5,0990 3,7417 4,8990 4,4721 4,2426 4 4 4,6904 5,2915 4,6904 5,6569 6 4,6904 4,2426 5,0990 5,0990 5,0990 5 5,5678 5 5,6569 6 4,4721 4,2426 4 5,6569 4,8990 4,8990 5,4772 5,8310 5 5,9161 5,1962 4,2426 4 4 2,4495 2,8284 4 0 4 4 5,0990 4,8990 3,3166 4,4721 4,6904 4,2426 4 4,2426 4,1231 5,3852 5,3852 6,1644 4,8990 5,4772 5,8310 6,3246 6,4807 5,8310 5,0990 4,8990 5,4772 5,2915 5,0990 5,4772 5,6569 5,8310 6,3246 6,1644 6,3246 6 6,3246 5,2915 6,4807 5,2915 5,6569 5,2915 4,8990 5,8310 6 5,8310 5,2915 5,2915 5,0990 5,8310 5,2915 6,6332 6,6332 6,4807 6 5,4772 5,6569 4,8990 6 5,8310 5,6569 5,2915 6 6 5,0990 5,2915 4,6904 5,6569 5,2915 5,2915 5,0990 5,4772 5,8310 6,1644 6,1644 5,0990 5,6569 6,3246 6,3246 5,0990 6,0828 6,0828 6,0828 6 6,3246 5,0990 5,4772 4,2426 5,8310 2,8284 5,2915 5,4772 5,6569 5 6,0828 5,5678 5,4772 5,0990 5,2915 4,2426 4,2426 4,6904 4 0 4,8990 5,8310 5,6569 4,7958 5,4772 5,8310 5,4772 3,7417 4 5,1962 5,7446 5,9161 6 5,0990 5,0990 5,8310 5,4772 5,8310 5,2915 5,2915 5,6569 5,8310 5,2915 5,0990 5,0990 5,6569 6,1644 6 6 6,3246 5,8310 6,1644 5,0990 6,3246 4,2426 4,8990 5,2915 4,6904 5,0990 5,6569 5,4772 5,0990 5,0990 5,6569 5,8310 5,6569 6,3246 6,3246 6 5,6569 5,0990 4,8990 5,4772 5,6569 6 5,8310 5,2915 5,8310 5,6569 4,8990 5,8310 5,4772 5,4772 5,2915 5,2915 6 6,1644 5,8310 6,3246 5,4772 5,2915 5,4772 5,2915 5,4772 5,2915 5,5678 6,0828 5,5678 6,6332 6,4807 5,4772 5,4772 5,4772 4,6904 5,6569 5,2915 5,4772 5,8310 5,3852 5,5678 6,0828 5,2915 5,0990 5,0990 4 4 5,0990 4 4,8990 0 5,6569 5,6569 4,5826 5,0990 5,2915 4,8990 4,4721 4,2426 5 5,9161 5,7446 6,4807 5,8310 5,6569 5,2915 5,0990 5,0990 4,6904 5,8310 6,1644 6,4807 5,8310 5,6569 5,4772 4,8990 5,6569 5,2915 5,2915 6 5,0990 5,4772 4,6904 5,2915 5,4772 5,0990 6 5,4772 5,8310 6,1644 6 5,8310 5,8310 6,1644 5,0990 6,1644 5,8310 5,8310 5,8310 5,0990 4,4721 4,6904 4,4721 4,4721 6,3246 6,3246 5,8310 6 6 5,6569 6,3246 6,1644 5,6569 6 5,8310 6,4807 6,1644 5,2915 6,1644 6,1644 5,8310 4,2426 4,4721 4,6904 4,6904 5,9161 6,5574 5,7446 6,9282 6,7823 6 6 6,1644 4,6904 5,6569 5,0990 3,7417 5,0990 5 6,7082 6,7082 5,6569 5,6569 5,6569 5,0990 4,8990 6 5,0990 5,8310 5,6569 0 2 5 5,6569 5,6569 5,0990 6,3246 6,1644 5 6,4031 6,2450 6,7823 6 5,8310 5,4772 5,0990 5,2915 4,8990 5,6569 6 6,3246 5,6569 5,6569 5,2915 4,6904 5,4772 5,0990 5,0990 5,8310 4,8990 5,2915 4,4721 5,0990 5,2915 4,8990 6,1644 5,2915 6 6,1644 6,1644 5,6569 5,6569 6 4,8990 6,3246 5,6569 5,6569 5,4772 4,8990 4,4721 4,4721 4,2426 4,2426 6,4807 6,4807 5,6569 6 6,1644 5,4772 6,1644 6 5,4772 5,8310 5,6569 6,3246 6 5,0990 5,8310 6 5,6569 4,2426 4,6904 4,4721 4,2426 6,0828 6,7082 5,9161 6,7823 6,9282 5,8310 5,8310 6 4,8990 5,4772 4,8990 4 5,2915 4,7958 6,8557 6,5574 5,4772 5,4772 5,4772 4,6904 5,0990 5,8310 4,8990 5,6569 5,6569 2 0 4,7958 5,8310 6 5,2915 6,1644 6,3246 5,1962 6,5574 6,2450 5,3852 4,7958 4,5826 5,5678 5,1962 5,3852 5 4,3589 5 5,1962 4,3589 4,3589 4,3589 4,7958 5,1962 5,1962 4,7958 5,7446 5 5,3852 4,5826 5,7446 5,3852 5 5 3,8730 4,3589 4,5826 5,0000 3,8730 4,3589 4,3589 5 4,7958 5,7446 5,7446 5,1962 5 4,1231 4,5826 5 4,7958 5 4,7958 4,3589 4,5826 4,7958 3,6056 5,1962 4,3589 4,7958 4,5826 4,3589 4,7958 5 5,1962 5,9161 6,2450 5 5 5,3852 5,1962 5 4,6904 5,6569 5,0990 5,5678 5,7446 4,3589 4,5826 4,3589 5,9161 5,1962 5 5,3852 5,3852 4,2426 5,4772 4,8990 4,3589 4,3589 4,3589 3,3166 3,6056 4,5826 3,3166 4,7958 4,5826 5 4,7958 0 4,7958 4,5826 3,8730 5 5,1962 3,1623 5,2915 4,8990 5,4772 4,8990 5,0990 6 5,8310 6 5,2915 5,2915 5,6569 5,0990 5,2915 5,2915 5,2915 5,4772 6,3246 6,1644 6 6,3246 5,8310 6,1644 5,0990 6,3246 6 5,4772 5,4772 4,8990 4,2426 5,0990 4,6904 5,2915 5,2915 5,6569 5,6569 5,4772 6,1644 6,1644 6,1644 5,8310 5,2915 5,4772 5,8310 5,6569 5,8310 5,8310 5,0990 4 3,7417 4,8990 5,8310 5,2915 5,0990 4,6904 5,0990 5,8310 5,8310 6 6,6332 6,6332 5,8310 5,6569 6 6 6 5,5678 5,9161 5,3852 5,6569 4,8990 5,4772 5,2915 5,2915 6,1644 6 6,1644 6,0000 6,1644 5,9161 6,2450 6,0828 4 3,1623 3,1623 4,4721 4 4 4,4721 5,4772 5,0990 5,6569 5,8310 4,7958 0 2,4495 4,6904 5,0990 4,8990 4,5826 5,3852 5,5678 5,0990 5,2915 5,2915 6,1644 6 6,1644 5,6569 5,4772 5,8310 5,4772 5,4772 5,2915 5,4772 5,8310 6,1644 6,3246 6 6,4807 6,1644 6,4807 5,4772 6,4807 6,1644 5,8310 5,6569 5,0990 4 4,6904 4,8990 5,0990 5,4772 5,4772 6 5,4772 6,3246 6,3246 6 6 5,2915 5,8310 6,1644 5,8310 5,6569 5,6569 5,4772 3,7417 3,4641 4,8990 6,1644 5,2915 5,2915 5,0990 5,2915 5,6569 5,8310 6,1644 6,7823 6,7823 6,1644 5,6569 6,1644 6,1644 6,1644 5,5678 6,2450 5,7446 5,6569 5,0990 5,4772 5,4772 5,2915 6,3246 6,3246 6,3246 6,1644 6,1644 6,0828 6,2450 6,0828 4,4721 3,4641 3,7417 4,6904 4,4721 4,4721 4,6904 5,8310 5,2915 5,6569 6 4,5826 2,4495 0 4,8990 5,4772 5,2915 4,3589 5,7446 5,3852 5,8310 4,8990 4,6904 5,6569 5,2915 5,2915 5,0990 4,8990 5,4772 5,6569 4,8990 4,8990 4,4721 4,8990 6 5,0990 5,4772 6,1644 5,2915 5,2915 5,0990 6,1644 5,8310 5,4772 5,0990 4,4721 4,8990 5,4772 5,0990 4,8990 4,6904 5,2915 5,0990 5,2915 6,1644 6,1644 6 5,0990 4,6904 5,0990 5,4772 5,0990 5,4772 5,2915 4,8990 5,4772 5,2915 4,6904 5,4772 5,0990 5,2915 5,0990 4,8990 5,6569 5,8310 5,6569 6,1644 6,6332 5,4772 5,4772 5,4772 5,4772 5,2915 5,3852 5,9161 5,3852 6,1644 6 5,2915 4,6904 5,2915 6 5,6569 5,0990 5,4772 4,8990 5,1962 5,9161 5,7446 5,0990 5,0990 5,0990 4,2426 4 5,2915 4,2426 5,4772 4,8990 5,0990 5,2915 3,8730 4,6904 4,8990 0 5,2915 5,0990 4,1231 5,1962 5,3852 6,1644 4,6904 5,4772 5,8310 6,1644 6,3246 5,6569 5,0990 4,6904 5,0990 5,2915 4,8990 5,2915 5,6569 5,8310 6,1644 6 6 5,8310 6,1644 5,0990 6,1644 5,4772 5,4772 5,2915 4,6904 5,6569 5,8310 5,8310 5,0990 5,0990 5,0990 5,8310 5,2915 6,1644 6,1644 6 5,8310 5,2915 5,4772 5,2915 5,8310 6 5,8310 5,2915 5,8310 5,8310 4,8990 5,2915 4,6904 5,4772 5,0990 5,0990 4,8990 5,2915 5,6569 6,1644 6,3246 5,2915 5,4772 6,1644 5,8310 5,4772 5,9161 5,3852 5,5678 5,4772 5,8310 4,6904 5,4772 4,2426 6,1644 4,4721 5,4772 5,8310 6 5,3852 5,5678 5,5678 5,0990 4,8990 5,0990 4,4721 4,4721 4 4 3,7417 4,4721 6,3246 6,1644 5 5,0990 5,4772 5,2915 0 1,4142 5 5,3852 5,9161 6 4,4721 5,2915 5,6569 6 6,1644 5,4772 5,2915 4,8990 5,2915 5,4772 5,0990 5,4772 5,8310 6 6,3246 6,1644 6,1644 6 6,3246 5,2915 6,3246 5,6569 5,6569 5,0990 4,8990 5,4772 6 5,6569 5,2915 5,2915 5,2915 6 5,0990 6,3246 6,3246 6,1644 6 5,4772 5,6569 5,4772 6 5,8310 5,6569 5,4772 6 5,6569 5,0990 5,4772 4,8990 5,6569 5,2915 5,2915 5,0990 5,4772 5,8310 6,3246 6,4807 5,4772 5,6569 6 6 5,6569 5,7446 5,1962 5,3852 5,6569 5,6569 4,8990 5,6569 4,4721 6 4,6904 5,6569 5,6569 5,8310 5,5678 5,3852 5,7446 5,2915 5,0990 5,2915 4,6904 4,2426 4,2426 4,2426 4 4,2426 6,1644 6,3246 5,1962 4,8990 5,2915 5,0990 1,4142 0 4,7958 5,1962 5,7446 5,5678 4,7958 4,7958 5,7446 5,3852 5,5678 5,1962 5,1962 5,5678 5,7446 5 5 5 5,3852 5,7446 5,7446 5,3852 6,0828 5,5678 5,9161 5,1962 6,0828 5,5678 5,5678 5,1962 4,5826 4,5826 5,1962 5,1962 4,5826 5 5 5,5678 5 5,9161 5,9161 5,3852 5,5678 4,7958 5,1962 5,1962 5,3852 5,3852 5,1962 5 5 4,7958 4,3589 5,7446 5 5,3852 5,1962 4,7958 5,1962 5,3852 5,7446 6,4031 6,2450 5,1962 5,5678 5,5678 5,3852 5,1962 4,8990 5,4772 4,8990 5,7446 5,5678 5 5,1962 5 5,7446 5,3852 5,3852 5,1962 5,1962 4,6904 5,4772 5,4772 4,7958 4,7958 4,7958 4,3589 4,1231 5 4,1231 5,1962 5 5 5,1962 3,1623 4,5826 4,3589 4,1231 5 4,7958 0 5,2915 4,8990 5,5678 4,3589 4,7958 5,1962 6,0828 6,2450 5 4,7958 4,7958 4,7958 5 5 4,7958 5,3852 5,5678 6,5574 6,5574 6,0828 6,4031 6,2450 5,5678 6,2450 6,4031 5,9161 5 5 5,3852 5,5678 5,5678 5,3852 5 4,5826 5,5678 4,3589 6,0828 6,0828 6,2450 5,5678 5,7446 6,0828 6,2450 6,2450 5 5 4,7958 5,7446 5,3852 4,5826 4,1231 4,5826 5,7446 5,3852 5,1962 5,1962 4,7958 5,7446 5,9161 7,1414 6,0828 6,0828 6,4031 6,5574 6,2450 5,0990 4,2426 4,8990 5,1962 4,7958 4,3589 5,3852 5,3852 6,7082 6,0828 6,5574 6,4031 6,0828 6,1644 5,2915 4,8990 5,5678 5,7446 5,9161 5,3852 5 5,1962 5,3852 5,7446 5,9161 6,4031 6,5574 5,2915 5,3852 5,7446 5,1962 5,3852 5,1962 5,2915 0 4 5 4,5826 4,7958 5 5,7446 6,0828 5 4,5826 5 5,3852 5 5 4,7958 5,3852 5 6,4031 6,2450 5,7446 6,4031 6,2450 5,5678 6,0828 6,2450 5,9161 5 5 5 5,1962 5,5678 5 5 4,3589 5,5678 4,3589 5,9161 5,9161 5,5678 5,3852 5,5678 6,0828 6,2450 6,0828 4,5826 4,1231 5 5,3852 5,1962 4,7958 4,5826 4,5826 5,5678 5,5678 5,1962 5 4,5826 5,7446 5,5678 7 6,2450 5,9161 6,2450 6,4031 5,9161 4,6904 5,2915 4,8990 5,9161 5,5678 5 5,5678 5,3852 6,5574 6,0828 6,4031 6,2450 5,9161 6 5,4772 4,6904 6,0828 5,9161 5,9161 5,1962 5,1962 5,7446 5,3852 5,9161 5,7446 6,2450 6,2450 4,8990 5,5678 5,3852 5,3852 5,9161 5,7446 4,8990 4 0 PX88_neu PX82_neu PX71_neu PX7_neu frei_B frei_A PX97 PX96 PX95 PX94 PX93 PX92 PX91 PX89 PX87 PX86 PX85 PX84 PX83 PX81 PX79 PX78 PX77 PX76 PX75 PX74 PX73 PX72 PX69 PX68 PX67 PX66 PX65 PX64 PX63 PX62 PX61 PX59 PX58 PX57 PX56 PX55 PX54 PX53 PX52 PX51 PX49 PX48 PX47 PX46 PX45 PX44 PX43 PX42 PX41 PX39 PX38 PX37 PX36 PX35 PX34 PX33 PX32 PX31 PX29 PX28 PX27 PX26 PX25 PX24 PX23 PX22 PX21 PX19 PX18 PX17 PX16 PX15 PX14 PX13 PX12 PX11 PX9 PX8 PX6 PX5 PX4 PX3 PX2 PX1 PX9 PX8 PX7 PX6 PX5 PX4 PX3 PX2 PX1

Bezeichnung Bezeichnung Wichtigkeithoch1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Wichtigkeithoch Wichtigkeitnormal 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Wichtigkeitnormal Generation1 1 1 1 1 1 1 1 Generation1 Generation2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Generation2 Generation3 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Generation3 Generation4 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Generation4 Generation5 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Generation5 Generation6 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Generation6 Generation7 1 1 1 1 1 1 Generation7 Generationkeine1 1 Generationkeine BruderpaarBruder_PX35 1 1 BruderpaarBruder_PX35 BruderpaarBruder_PX42 1 1 BruderpaarBruder_PX42 BruderpaarBruder_PX46 1 1 BruderpaarBruder_PX46 BruderpaarBruder_PX8 1 1 BruderpaarBruder_PX8 BruderpaarBruder_PX81 1 1 BruderpaarBruder_PX81 BruderpaarBruder_PX89 1 1 BruderpaarBruder_PX89 BruderpaarBruder_PX92 1 1 BruderpaarBruder_PX92 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Bruderpaarnein1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Bruderpaarnein AehnlichkeitAehnlich_PX14 1 1 AehnlichkeitAehnlich_PX14 AehnlichkeitAehnlich_PX29 1 1 AehnlichkeitAehnlich_PX29 AehnlichkeitAehnlich_PX3 1 1 AehnlichkeitAehnlich_PX3 1 AehnlichkeitAehnlich_PX32 1 AehnlichkeitAehnlich_PX32 AehnlichkeitAehnlich_PX34 1 1 AehnlichkeitAehnlich_PX34 AehnlichkeitAehnlich_PX41 1 1 1 1 AehnlichkeitAehnlich_PX41 AehnlichkeitAehnlich_PX431 1 AehnlichkeitAehnlich_PX43 AehnlichkeitAehnlich_PX441 1 AehnlichkeitAehnlich_PX44 AehnlichkeitAehnlich_PX45 1 1 AehnlichkeitAehnlich_PX45 1 1 AehnlichkeitAehnlich_PX46 1 1 AehnlichkeitAehnlich_PX46 AehnlichkeitAehnlich_PX47 1 1 1 AehnlichkeitAehnlich_PX47 AehnlichkeitAehnlich_PX53 1 1 1 1 AehnlichkeitAehnlich_PX53 AehnlichkeitAehnlich_PX54 1 1 AehnlichkeitAehnlich_PX54 AehnlichkeitAehnlich_PX58 1 1 AehnlichkeitAehnlich_PX58 AehnlichkeitAehnlich_PX63 1 1 1 AehnlichkeitAehnlich_PX63 AehnlichkeitAehnlich_PX73 1 1 AehnlichkeitAehnlich_PX73 AehnlichkeitAehnlich_PX771 1 1 AehnlichkeitAehnlich_PX77 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Aehnlichkeitnein 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Aehnlichkeitnein Groessegross 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Groessegross Groesseklein 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Groesseklein Groessemittel 1 1 1 1 1 1 1 1 1 1 Groessemittel Groesseriesig1 1 1 1 Groesseriesig Haptikhart1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Haptikhart 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Haptikweich 1 1 1 1 Haptikweich Position_allgemeinhaengt1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Position_allgemeinhaengt Position_allgemeinsteht1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Position_allgemeinsteht Position_detailhaengt_mit_Abstand1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Position_detailhaengt_mit_Abstand Position_detailhaengt_ohne_Abstand1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Position_detailhaengt_ohne_Abstand Position_detailsteht1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Position_detailsteht MaterialBeton 1 1 1 1 MaterialBeton 1 1 1 1 1 1 1 1 MaterialGips 1 1 1 1 1 MaterialGips MaterialKunstleder 1 1 1 1 1 1 MaterialKunstleder MaterialPapierpaste 1 1 1 1 MaterialPapierpaste MaterialPaste1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 MaterialPaste MaterialPlastik 1 1 1 1 1 MaterialPlastik MaterialPolyester1 1 MaterialPolyester 1 1 1 1 1 1 MaterialSilikon 1 1 1 1 MaterialSilikon 1 1 1 1 Aufbauabgegossen 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Aufbauabgegossen Aufbaugebaut1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Aufbaugebaut Aufbaugenaeht 1 1 1 1 1 1 1 1 1 1 1 Aufbaugenaeht Aufbaulaminiert 1 Aufbaulaminiert Aufbau_detailabgegossen 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Aufbau_detailabgegossen Aufbau_detailgebaut1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Aufbau_detailgebaut Aufbau_detailgebaut_gefuellt 1 Aufbau_detailgebaut_gefuellt Aufbau_detailgenaeht_gefuellt 1 1 1 1 Aufbau_detailgenaeht_gefuellt Aufbau_detailgenaeht_hohl 1 1 1 1 1 1 1 Aufbau_detailgenaeht_hohl Aufbau_detaillaminiert_gefuellt 1 Aufbau_detaillaminiert_gefuellt Farbeblau 1 1 1 1 1 1 1 1 Farbeblau Farbebunt 1 Farbebunt FarbeFarbe_X 1 1 FarbeFarbe_X 1 1 1 Farbegelb 1 1 1 1 Farbegelb 1 1 1 1 1 1 1 1 1 1 1 Farbegrau 1 1 1 Farbegrau Farbegruen 1 Farbegruen Farbegrün 1 Farbegrün Farbehellgruen 1 Farbehellgruen Farbemilch 1 1 Farbemilch 1 1 Farbeorange.rot1 1 1 1 1 1 Farbeorange.rot Farberosa 1 Farberosa 1 Farberot 1 Farberot Farbeschwarz 1 1 1 1 1 Farbeschwarz Farbeunbekannt 1 1 1 1 1 Farbeunbekannt Farbeweiss1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Farbeweiss 1 1 1 1 1 1 1 1 1 1 Farbbasisfabric 1 1 Farbbasisfabric FarbbasisFarbauftrag1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 FarbbasisFarbauftrag FarbbasisMaterialfarbe 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 FarbbasisMaterialfarbe FarbbasisMetallbeine 1 1 1 1 FarbbasisMetallbeine FarbbasisPU.gruen 1 1 FarbbasisPU.gruen FarbbasisSilikon.gruen 1 FarbbasisSilikon.gruen Farbbasisunbekannt 1 1 1 1 Farbbasisunbekannt Farbkombinationblau.orange 1 1 Farbkombinationblau.orange Farbkombinationgelb.weiss 1 1 Farbkombinationgelb.weiss Farbkombinationgrau.gruen 1 1 Farbkombinationgrau.gruen Farbkombinationgrau.milch 1 Farbkombinationgrau.milch Farbkombinationgrau.weiss 1 Farbkombinationgrau.weiss Farbkombinationnein1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Farbkombinationnein Facts Imprint How toReach CeMM Acknowledgements Testimonials FactsFigures and Publications Directory Employees Ph.D. Program Scientific Advisory Board Principal Investigators and TherapeuticsDiagnostics Post-Genomic Technologies Immune Disorders and Inflammatory Diseases Infectious Diseases Cancer atScience CeMM Discussion on Art and Science Director’s Intro Science CeMM Research Report 2013 Farbkombinationweiss.milch 1 1 1 Farbkombinationweiss.milch Zweites_MaterialHolzkiste 1 1 Zweites_MaterialHolzkiste 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 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Einsatz_allgemeineinfach1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Einsatz_allgemeineinfach

Einsatz_allgemeinnein1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Einsatz_allgemeinnein

Einsatz_detail1Einsatz_Ausguss 1 1 1 1 1 Einsatz_detail1Einsatz_Ausguss

1 1

Einsatz_detail1Einsatz_Glaslinse Einsatz_detail1Einsatz_Glaslinse Einsatz_detail1Einsatz_M1 1 Einsatz_detail1Einsatz_M1 1

Einsatz_detail1Einsatz_M2 pp. Einsatz_detail1Einsatz_M2 1

Einsatz_detail1Einsatz_M3 80—85 Einsatz_detail1Einsatz_M3

1 pp. pp.

Einsatz_detail1Einsatz_M4 pp. Einsatz_detail1Einsatz_M4 1 1 90—93 86—87

Einsatz_detail1Einsatz_Noppen 88—89 Einsatz_detail1Einsatz_Noppen Einsatz_detail1Einsatz_Schlauch 1 1 Einsatz_detail1Einsatz_Schlauch 1 1

Einsatz_detail1Einsatz_Staender pp. Einsatz_detail1Einsatz_Staender 1 1 1 1

Einsatz_detail1Einsatz_Ventil 94—100 Einsatz_detail1Einsatz_Ventil Einsatz_detail1nein1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Einsatz_detail1nein Einsatz_detail2Einsatz_Glas 1 1 Einsatz_detail2Einsatz_Glas 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1

Einsatz_detail2Einsatz_Metall Einsatz_detail2Einsatz_Metall Einsatz_detail2Einsatz_Mutation 1 1 1 1 Einsatz_detail2Einsatz_Mutation Einsatz_detail2Einsatz_NA 1 Einsatz_detail2Einsatz_NA Einsatz_detail2Einsatz_Plastik 1 1 1 Einsatz_detail2Einsatz_Plastik Einsatz_detail2Einsatz_Schaumgummi 1 1 Einsatz_detail2Einsatz_Schaumgummi Einsatz_detail2nein1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Einsatz_detail2nein IronieIronie1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 IronieIronie Ironienein1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Ironienein Biomorphbiomorph 1 1 1 1 1 1 1 1 1 1 Biomorphbiomorph Biomorphnein1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Biomorphnein Biomorph_detailbiomorph_andere 1 1 1 1 Biomorph_detailbiomorph_andere Biomorph_detailbiomorph_tailliert 1 1 1 1 1 1 Biomorph_detailbiomorph_tailliert Biomorph_detailnein1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Biomorph_detailnein Schnorchel_allgemeinnein1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Schnorchel_allgemeinnein Schnorchel_allgemeinSchorchel 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Schnorchel_allgemeinSchorchel Schnorchel_detail1nein1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Schnorchel_detail1nein Schnorchel_detail1Schnorchel_schmal 1 1 1 1 1 1 1 1 1 Schnorchel_detail1Schnorchel_schmal Schnorchel_detail1Schnorchel_Variation 1 1 1 1 1 1 1 1 Schnorchel_detail1Schnorchel_Variation Schnorchel_detail2nein1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Schnorchel_detail2nein Schnorchel_detail2Schnorchel_Aufsatz 1 1 Schnorchel_detail2Schnorchel_Aufsatz Schnorchel_detail2Schnorchel_Metall 1 Schnorchel_detail2Schnorchel_Metall Schnorchel_detail2Schnorchel_rund 1 1 1 1 Schnorchel_detail2Schnorchel_rund Schnorchel_detail2Schnorchel_schmal 1 1 1 1 1 1 1 1 1 Schnorchel_detail2Schnorchel_schmal DUO_GruppeDuo 1 1 1 1 1 1 1 1 1 1 DUO_GruppeDuo DUO_GruppeGruppe1 1 1 1 1 1 DUO_GruppeGruppe DUO_Gruppesingle1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 DUO_Gruppesingle Oeffnung_allgemeingeschlossene_Form1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Oeffnung_allgemeingeschlossene_Form Oeffnung_allgemeinHuelle 1 1 1 1 1 1 1 1 1 1 1 1 Oeffnung_allgemeinHuelle Oeffnung_allgemeinMutationA 1 Oeffnung_allgemeinMutationA Oeffnung_allgemeinMutationB 1 Oeffnung_allgemeinMutationB Oeffnung_detailgeschlossene_Form1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Oeffnung_detailgeschlossene_Form Oeffnung_detailHuelle_gefuellt 1 1 1 1 1 Oeffnung_detailHuelle_gefuellt Oeffnung_detailHuelle_leer 1 1 1 1 1 1 1 Oeffnung_detailHuelle_leer Oeffnung_detailMutationA 1 Oeffnung_detailMutationA Oeffnung_detailMutationB 1 Oeffnung_detailMutationB Formmerkmal2_Spoiler 1 1 1 1 Formmerkmal2_Spoiler FormmerkmalHoehle 1 1 FormmerkmalHoehle FormmerkmalKombination 1 FormmerkmalKombination FormmerkmalLoch 1 1 1 1 1 FormmerkmalLoch Formmerkmalmittiger_Einsatz1 1 1 1 1 1 1 1 1 1 Formmerkmalmittiger_Einsatz Formmerkmalnein1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Formmerkmalnein FormmerkmalVertiefung 1 1 1 1 1 1 1 FormmerkmalVertiefung HalbkugelHalbkugel 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 HalbkugelHalbkugel Halbkugelnein1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Halbkugelnein Gereihteinfach 1 1 1 1 1 1 1 1 1 1 Gereihteinfach Gereihtgereiht 1 1 1 1 1 Gereihtgereiht Gereihtnein1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Gereihtnein Konvexkonvex 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Konvexkonvex Konvexnein1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Konvexnein Konkavkonkav 1 1 1 1 Konkavkonkav Konkavnein1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Konkavnein Voluminoesflach1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Voluminoesflach Voluminoesflach.voluminoes 1 1 1 1 1 1 1 1 1 1 1 1 1 Voluminoesflach.voluminoes Voluminoesvoluminoes1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Voluminoesvoluminoes Oberflaecheglatt1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Oberflaecheglatt Oberflaechestruktur 1 1 1 1 1 1 1 1 1 Oberflaechestruktur StrukturMuta1 1 StrukturMuta1 StrukturMuta2 1 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1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Zusatztitelnein “Austria and Britain share a belief that science and innovation are at the heart of sustainable economic growth. The research undertaken at CeMM is world-leading and could well change all our lives. The ­environment in which the talented team led by Prof Superti-Furga works is exciting and cosmopolitan. It fosters creative thinking, new approaches to old ­problems and cross-cutting collaboration. CeMM has already made ­significant break- throughs in the study of diabetes,­ something close to my heart as my father has lived with the ­condition for more than 30 years. Recent developments in cancer research promise even more for the future.”

Susan le Jeune d’Allegeershecque Her Britannic Majesty’s Ambassador to the Republic of Austria “I spent a few (regrettably, too few) hours at CeMM, the Centre for ­Molecular Medicine of the Austrian Academy of Sciences, on a rainy day in November 2013. I was literally dazzled by the highly creative and stimulating atmosphere, the huge number of outstanding,­ enthusiastic young ­people, the ingenious vision of the Director and senior scientists, the state-of-the-art­ instrumentation­ and infrastructure. A wonderful place, a dream place, to do research. I wish there were more in the world.”

Dr. Fabiola Gianotti Particle Physicist, CERN, Geneva “As the chair of the scientific ­advisory board (SAB), it is a treat to observe the impressive develop- ment of CeMM ­during the past few years. Indeed, under the visionary leadership of its Director, the SAB believe that CeMM has become a new scientific powerhouse in the heart of Europe. It successfully competes with many of the best institutes worldwide. This is well documented by a steady stream of high-impact research, including­ two remarkable studies in the field of cancer biology in recent days. ­Given its unique, collaborative ­spirit and its highly motivated and talented ­students and scientists, the SAB look ­forward to the emergence of even more world class science at CeMM and its translational imprint. We believe that the ­people of Austria are being very well served by this scientific gem!”

Prof. Dr. David Livingston Deputy Director, Dana-Farber/Harvard Cancer Center, Boston, USA Chair of CeMM’s Scientific Advisory Board “I have had the great pleasure to be a Member of CeMM’s Scientific ­Advisory Board (SAB) since the inception of the Institute. Within this role I have watched CeMM grow from its concept stage to an Institute carrying out world-­class science within a remarkably­ short period! CeMM’s ­publication record is enviable and despite its small size, its research, focusing on cancer, infection and inflammation and epigenetics, is ­outstanding.”

Prof. Dr. Nadia Rosenthal Director, Australian Regenerative Medicine Institute, Melbourne, AU Member of CeMM’s Scientific Advisory Board “It is an honor and pleasure to dedicate our bodies to science – even though it’s for the purpose of a picture­ for now. We fully trust in CeMM to handle our and any ­other bodies with care. To a better world!”

Stermann & Grissemann Comedians, TV-Stars, Compéres “Willkommen­ Österreich”­ “As an interdisciplinary research ­institute of the Austrian Academy of Sciences studying the human system and its molecular inner workings, the mission of CeMM is to assist in ­preparing the predictive, preventive and personalized ­medicine of the future.”

Prof. Dr. Anton Zeilinger President of the Austrian Academy of Sciences Life at CeMM

+ Great Lectures + Scientific Meetings + Great Competitions + Great Celebrations + Good Scientific Citizenship Great Lectures CeMM’s organized seminars and lecture series held throughout the year provide an important source of information and inspiration not only to the scientists at CeMM, but also to scientists and medical professionals at other local institutes and universities, and some- times to the interested general public.

CeMM Karl Landsteiner Lecture

A Dynamic Lecture The annual Karl Landsteiner lecture was Hans Clevers’ research has made fundamental Dutch scientist Hans ­Clevers launched at CeMM in 2007 to honor the Austrian breakthroughs in a number of different fields presents his research over the last decade on the ­immunologist renowned for discovering the over the course of his career, and his most ­dynamic life of the intestinal four human blood groups, which earned him the recent topic, stem cell biology, is no exception. stem cell. Nobel Prize in Physiology or Medicine in 1930. His ­lecture, entitled “Stem Cells of the Bowel: The recipient of the lectureship is selected by Bright Side, Dark Side”, was presented to a CeMM faculty for his/her outstanding achieve- mixed ­audience of 350 people from all scientific ments in the area of molecular medicine. This ­disciplines alongside other interested parties in year marked the seventh Karl Landsteiner ­lecture, the Festsaal of the Austrian Academy of Sciences which was presented by Dr. Hans Clevers of on the 6th May, 2013. the Hubrecht Institute in The Netherlands, and President of the Royal Netherlands Academy of Sciences.

The Power of a Single Cell

Using entertaining animations peppered three-dimensional “mini” guts long-term in with ­little known historical insights, Hans the laboratory. These mini-guts could even be ­Clevers presented the results of several projects ­transplanted back into a mouse with a damaged ­performed in his laboratory over the last ten gut, and function normally. They showed the years, all centered around the dynamic lives same thing for liver stem cells. And in another of intestinal stem cells. He explained that the project, they pinpointed the intestinal stem cell ­epithelial cell layer, which lines the 12 meters niche, which is the cellular microenvironment of the small intestine and helps us digest food, required to support the stem cells and thereby is exposed to one of the most violent biological renewal of the intestine. environments on the planet, i.e. the contents of the gut. As such these cells don’t survive very Being able to grow healthy, functional tissue in long, and the entire lining of the gut needs to the laboratory in this way could revolutionize­ be replaced every four days. This massive cell regenerative medicine and the ability to cure ­turnover is made possible by intestinal stem patients with intestinal and liver d­amage. cells, which ensure the continuous supply of And the system will also give scientists a new epithelium. ­much-needed boost to better model and thereby study associated diseases such as colon ­cancer, Hans explained how work done by his group led in vitro. Unsurprisingly, there were many to the breakthrough discovery of the identity ­questions, ­particularly on the properties of these of the elusive intestinal stem cell in mice. In an stem cells and the many possibilities of using unprecedented next step, they showed how they this new model to answer previously intractable could use a single one of these stem cells to grow biomedical­ questions.

Ce — M­—M­— Research Report 2013 The SMART Lecture Series and the “God Particle”

On Monday 25th November 2013, Dr. Fabiola Dr. Gianotti explained the three features required Elementary Particles Gianotti from the Physics Department at CERN, to study the behaviour of elementary particles: Fabiola Gianotti from CERN, Switzerland, describes how Switzerland, presented a fantastic SMART an accelerator, a detector and computing power. studying the behaviour of ­lecture at CeMM entitled “The Higgs Boson and These three features are combined in the Large elementary particles such as the Higgs boson can advance Our Life”, to a packed audience. The SMART Hadron Collider, which is a subterranean ring, the frontiers of technology. (Science, Medicine, Art, Research & Technology) 27km in circumference, lying across the border lecture series is a biannual event hosted by CeMM between Switzerland and France. Proton streams to address current scientific challenges spanning extracted from hydrogen gas are accelerated in science, art, and society. The lecture series aims a vacuum around the ring at immense speeds. to encourage out-of-the-box-thinking as well as Upon particle collision, energy is released which to establish a dialogue with the broader public. can be transformed into matter – in the form of larger, heavier particles. Through this process, Following a warm introduction by CeMM’s the Large Hadron Collider is able to create Higgs Scientific Director, Giulio Superti-Furga, Dr. bosons and other particles for observation and Gianotti began her talk by introducing CERN, study. By advancing the frontiers of techno­logy, the world’s largest particle physics laboratory,­ such discoveries will ultimately prove to be ­currently engaging over 11,000 scientists from ­beneficial to society. more than 60 countries. CERN’s primary ­mission is the study of elemental particles, and Many questions followed Dr. Gianotti’s Dr. Gianotti went on to describe how an under- ­fascinating lecture, including whether the standing of the ‘very small’ can often help us to Higgs boson can help us better understand dark understand the ‘very big’. ­matter, or the origin of the universe. Dr. Gianotti explained that they aim to recreate conditions at The Higgs boson is an elementary ­particle, the beginning of the universe for study, and then first discussed in 1964. It’s discovery by translate these finding back in time. CERN, announced on the 4th July 2012, was ­monumental. During the almost 40 year At CERN there is a strong focus on training the search for this ­particle, CERN developed and next generation of scientists and more than half ­constructed the Large Hadron Collider over a 20 of CERN’s collaborative scientists are under year period, which was critical for the discovery the age of 30. In an inspirational take home of the Higgs boson. ­message for the young scientists in the ­audience, Dr. Gianotti emphasised that curiosity was essential for research and for driving motivation.

Life 83 84 26.08.2013 24.09.2013 06.11.2013 Impromptu Impromptu Joint MUW - CeMM Overview Elke Deuerling Menno C. van Zelm Impromptu Seminar Chair of Molecular Dept. Immunology,­ Paolo Bernardi CeMMinar/Impromptu Series Microbiology, University Erasmus­ MC, University of Padova, of Konstanz University­ Medical Italy “Quality Control Center, Rotterdam,­ “Mitochondria and Processes­ at the the ­Netherlands cancer:­ A molecular 21.01.2013 27.02.2013 27.05.2013 02.07.2013 Ribosome”­ “Build-up of mechanism for the CeMMinar Impromptu CeMMinar Impromptu Host: Giulio Superti- immunological­ memory Warburg” Jiri Lukas John Castle Stephan Beck Roland Arnold Furga in young children” Hosts: Karin Nowikovsky Novo Nordisk­ TRON - Translational Research Department­ Philip M. Kim Laboratory Host: Kaan Boztug (MUW) & Keiryn Bennett Foundation­ Center Oncology, University of Cancer Biology,­ Terrence Donnelly 03.09.2013 for Protein Research, Medical Center, Johannes University­ College Centre for Cellular and Impromptu 01.10.2013 11.11.2013 ­Faculty of Health Gutenberg University, London (UCL) Cancer Biomolecular Research, Ross Dickins Impromptu CeMMinar and Medical ­Sciences, Mainz, Germany Institute University of Toronto Walter and Eliza Hall Eric Haura Adriano Aguzzi University­ of “Next generation “Pinball Methylome: “Exploring genetic Institute, Victoria, H. Lee Moffitt Cancer Institute of Copenhagen,­ Denmark sequencing for truly Functional insights interactions in E. coli Australia­ Center & Research Neuropathology,­ “Spatial and temporal individualized vaccines?” from multi-dimendional and human cancer cells: “Mechanisms of Institute University­ Hospital regulation of the DNA Host: Robert Kralovics perturbations”­ enlighting functional ­leukemia suppression by “Bringing Network Zurich damage response: Host: Christoph Bock cross-talk in bacteria the transcription factors Medicine to the Clinic: “The biology of mechanisms and 08.04.2013 and targeting cancer Pax5 and Ikaros” Annotating Cancer via mammalian­ prions” unexpected­ limitations CeMMinar 06.06.2013 vulnerabilities” Hosts: Florian Grebien/ Protein Complexes” Host: Giulio Superti- of genome surveillance” Steve Jackson Impromptu Host: Jacques Colinge & Giulio Superti-Furga Host: Giulio Superti- Furga Host: Joanna Loizou Department of Laura Steenpass Sebastian Nijman Furga Biochemistry­ & Institute for Human 10.09.2013 21.11.2013 11.02.1013 Cancer Research Genetics, University of 09.07.2013 Impromptu 21.10.2013 Impromptu CeMMinar UK Laboratories,­ Duisburg-Essen Impromptu Stephanie Dumon Impromptu Andre Franke Tony Green The ­Gurdon Institute, “Imprinting of RB1: Richard R. Meehan School of Immunity Prof. Dr. Michael Rehli Institute of Clinical Department of University­ of Cambridge origin­ and mechanism” MRC Human Genetics and Infection, College Department of Internal Molecular Biology, Haematology,­ “Cellular responses to Host: Denise Barlow Unit, Western General of Medical and Dental Medicine III, University Christian-Albrechts- Cambridge­ Institute DNA damage” Hospital, Edinburgh, Sciences, University of Hospital Regensburg University of Kiel for Medical Research, Host: Joanna Loizou 07.07.2013 Scotland Birmingham “The regulomes of “A systematic analysis­ University­ of Cambridge Special Seminar “5-Hydroxymethylation “The MYB protein in human monocytes to study host-gut “JAK/STAT signalling 29.04.2013 Ivan Dikic and the Epigenetics of normal and malignant and everything else – microbiome­ interactions” and malignancy – CeMMinar Institute of Biochemistry Identity” haematopoiesis” Insights from FANTOM5 Host: Kaan Boztug clonal complexity Georg Wick II, Goethe University­ Host: Denise Barlow Host: Florian Grebien/ CAGE-data” and stem cell” Div. for ­Experimental School of Medicine, Giulio Superti-Furga Host: Christoph Bock 28.11.2013 Host: Robert Kralovics Pathology & ­University of Frankfurt, 24.07.2013 Impromptu Immunology,­ Laboratory­ Germany Impromptu 17.09.2013 28.10.2013 Yinon Ben-Neriah 25.02.2013 of Autoimmunity, “Ubiquitination Berend Snijder Impromptu CeMMinar Lautenberg Center for CeMMinar Biocenter­ Innsbruck in ­regulation of CeMM Natalie de Souza Ivan Dikic Immunology, Hebrew Frederic Geissmann Medical University ­inflammation and “Inferring functional Senior Editor Nature Goethe University University-Hadassah Division of ­Immunology, “The Immunology of autophagy” interactions between Methods Frankfurt Medical School Infection & Atherosclerosis” Host: Giulio Superti- genes from high- “Behind the scenes at “Ubiquitin & autophagy “Inflammation from an ­Inflammatory Disease Host: Giulio Superti- Furga content perturbation Nature Methods” networks in ­regulation epithelial perspective” (DIIID), King’s College Furga screens” Host: Giulio Superti- of infection & Hosts: Giulio Superti- London 01.07.2013 Furga ­inflammation” Furga, Joanna Loizou “In Vivo Differentiation­ CeMMinar Host: Giulio Superti- and Sebastian Nijman & Functions of Akinori Takaoka Furga Macrophages”­ Division of Signalling in Host: Christoph Binder Cancer and Immunology,­ Institute for Genetic Medicine, Hokkaido University “Innate immune signaling­ networks during host-microbe interaction” Host: Andreas Bergthaler

Ce — M­—M­— Research Report 2013 Life 85 86 Scientific Meetings Opening Christian Doppler Laboratory at CeMM, Austrodrugs Meeting Communicating scientific results is essential for advancing ­science, and probably the most efficient and fun way to do this is at a ­conference. Conferences enable the direct communication and On February 28 and March 1, 2013, more than The opening was celebrated with a ­scientific ­discussion of results between scientists from a certain field, and 130 academic chemical biologists and industrial symposium on the research topics of the oftentimes scientists of different disciplines. This provides a drug discoverers met at CeMM for a scientific CD Laboratory. Maria M. Mota (Instituto de ­symposium and the third Austrodrugs meet- Medicina Molecular, University of Lisbon) gave ­breeding ground for new ideas and research directions. CeMM ing. Following speeches by the project partners a fascinating keynote lecture on “Approaching ­sponsors several national and international conferences each year. and the president of the Austrian Academy of malaria from the host side but not always”. Her In 2013, besides several smaller meetings, two conferences were ­Sciences, Prof. Helmut Denk, the Christian lecture, together with Johan Neyt’s presentation Doppler Laboratory for Chemical Epi­genetics the ­following day, represents a role model for ­organised by CeMM scientists and held at the institute. The and Antiinfectives was officially opened ­targeting host-pathogen interactions with small ­organisers would like to thank all the speakers and participants by Prof. Reinhart Kögerler, President of the molecules. The symposium continued with a who contributed to the success of these meetings. ­Christian Doppler Research Association. series of lectures on chemical biology approaches to epigenetics, the second focus of the Christian The newly established Christian Doppler Doppler lab. ­Laboratory is a public-private partnership between CeMM, Boehringer Ingelheim, and The afternoon of March 1 was dedicated to Haplogen. It aims to develop novel screening­ the third Austrodrugs meeting. Five academic technologies and identify chemical probe and eight industrial speakers gave updates Next Generation Sequencing ­compounds as a basis for future drug develop- and ­presented their tools, resources, and ment projects with the corporate partners. In ­opportunities and needs for collaboration. Vienna Symposium and Workshop the chemical epigenetics module, the team ­Discussions then continued informally at a around CeMM’s Stefan Kubicek aims to develop ­cocktail reception, further strengthening the ­technologies in collaboration with Oncology interactions between Austrian academic ­chemical On April 9, 2013, researchers from around Further­more, a keynote lecture by Prof. ­Reinhold Research at Boehringer Ingelheim RCV GmbH biologists and industrial drug discoverers. Based ­Vienna gathered at CeMM to discuss the latest­ Schäfer (Vice director of the Charité & Co KG to identify and characterize small on the success of the meeting, we are sure that developments and future perspectives of ­Comprehensive Cancer Center) highlighted the molecules and ‘druggable’ proteins regulating additional collaborations will emerge. We are ­arguably the hottest technology in biomedicine: medical ­relevance of genome-scale technology chromatin structure and function. In a second looking forward to learning about their progress Next Generation Sequencing (NGS). NGS has for cancer research, and a subsequent technical module, their goal is to identify chemical probes at the next Austrodrugs meeting in 2014. made it relatively routine to determine the DNA workshop provided the venue for discussing the for host factors of infectious diseases based sequence of entire human genomes (a ­procedure challenges of this complex technology in greater on molecular targets derived by a powerful that would have cost millions of Euros just a few depth. The meeting was organized by CeMM screening approach using human haploid cells years ago), providing unprecedented research Principal ­Investigator Christoph Bock, who also implemented at Haplogen GmbH. Bringing these opportunities in organisms ranging from co­ordinates the joint Biomedical Sequencing targets together with CeMM’s comprehensive ­bacteria and plants to insects and mammals.­ Facility of CeMM and the Medical University compound library and screening expertise will The ­symposium provided an overview of NGS- of Vienna, and by Andreas Sommer, who is the generate novel chemical probes that can be used enabled research in Vienna, with scientific talks head of the NGS unit at the Campus Science for proof-of-concept studies. by Renée Schroeder (MFPL), Sebastian ­Nijman Support Facilities at the Vienna Biocenter (CSF). (CeMM), Julius Brennecke (IMBA), Franco Both facilities also presented their ­sequencing ­Laccone (MedUni Vienna), Johannes Zuber (IMP) services, which are provided at a significantly Opening Christian and Renate Panzer (St. Anna CCRI). subsidized rate to academic researchers in Doppler Lab ­Austria, thus contributing to the wide availability CDG President Reinhart Kögerler, Academy President­ of this breakthrough technology to researchers in Helmut Denk, Georg Vienna and Austria. Casari, Norbert Kraut and Giulio ­Superti-Furga at the ­opening of the Christian Doppler Laboratory for Chemical Epigenetics­ and Anti­infectives, on February 28th, 2013.

Ce — M­—M­— Research Report 2013 Life 87 88 Mountainbike Race Team Race on April 22nd, Camillo Sanchez, part of 2013. Each participant was the Colombian national­ required to ride a 7km Great Competitions team for the World cross-country trail through Championships­ in Canberra forests and vineyards in the 2010, captained CeMM’s beautiful surroundings of When it comes to sports, CeMMies are multi-talented, mountainbike team with Kahlenberg on the outskirts Adriana Goncalves, Ciara of Vienna. We placed 12th fearless and ambitious team players. Cleary and Lindsay Kosack out of 35 teams! in the Wien Energie MTB

SURF 2013 a high team spirit spurred On September 11th, 2013 on by enthusiastic cheer­ the soccer teams of IMP, leaders the CeMM soccer IMBA, ISTA, MFPL, GMI, team carried the day! the Austrian Academy of CeMM won each of its Sciences and Companies matches with a total score of the Vienna Biocenter of 17:5. We ­congratulate Cancer Research Run and CeMM met for the all teams and thank coach The 7th Cancer ­Research SU(mmer)R(esearchers) Mischa Pilz for his very Run took place on ­October F(ootball) Tournament. good job and IMBA for the 5th, 2013. The sports event With fancy footwork, ­excellent ­organization of provides an opportunity­ elaborate strategy, and the tournament.­ to raise awareness of the fight against cancer and establish additional,­ independent­ and private research funding.­ CeMM sponsored 15 runners from the ­institute who mastered 274 rounds with about 232 ­kilometers in total. Revenue from the 7th Cancer Research Run will be pumped into a research project aimed at establishing­ treatments that are specifically co­ ordinated towards genetic mutations and protein ex- pressions in tumors.

Vienna City Marathon Some thirty-six CeMM scientists­ and administrative­ personnel participated in the 30th ­Vienna City Marathon on Sunday, April 14, 2013. Ph.D. student Carol Ann Eberle, ran the half-­ marathon in 01:27:16, which was the 11th best time out of 4271 women and the second place in her age bracket! On ­average the CeMM teams needed about 4 hours and 7 ­minutes for the 42 kilometer­ distance. CeMM congratulates the nine running teams and wishes them all the best for their next competitions! Collaboration I A joint research project of the CeMM and ETH Great Celebrations ­Zurich, published in ­Nature Methods­ on March 4th, 2013 not only pointed out “Work hard, party hard”, is a motto at CeMM, which contributes to the merits of a long-lasting international collaboration,­ a motivating and inspiring work atmosphere and makes this place it seems to make the something special. Following tradition, the first year’s students have complete­ mapping­ of the interactions within the task of organizing a Halloween ball and each new generation has the ­human proteome achievable.­ While the big shoes to fill. It seems as if creativity has no limits! Every year the Viennese­ contributors were ­honored by ­Giulio motto is more challenging, the labs get more creative and the with the ­traditional ­costumes get more fanciful! In May 2013 Keiryn Bennett and Lindsey “coronation”,­ the ­colleagues in Zurich took Kosack initiated CeMM’s first International Food Festival, which was part virtually via Skype. a big hit and will hopefully become a tradition as well. Another small gourmet festival was a kick-off of the icecream season on CeMM’s terrace in June. However, the most pleasant reason for a ­celebration is the growing number of outstanding publications!

Collaboration II On August 25th, 2013 International ­Nature Methods ­ Food Festival­ announced that Haplogen, A culinary world trip a spin-off and partner of at CeMM. CeMM, made available their large collection of haploid human cell lines. The study is a best practice model for scientific teamwork. Some 35 scientists from CeMM and Haplogen ­contributed to the ­publication and celebrated their huge collaborative success with champagne, wine and cheese.

Summer Feeling Ice cream on CeMM’s terrace.

Translational Success CeMM and the ­Medical University­ of Vienna ­published the new dis- covery of a mutation in December 2013 in the New England Journal of Medicine (NEJM) and this mutataion was a main topic at the Annual ­Meeting of American ­Society of Hematology­ (ASH). The findings of Robert Kralovics’ group were also presented at a press conference in Vienna and bring hope to millions­ of Myelopro­ liferative neoplasm­ patients.­ Christmas Party On December 19th, 2013, we celebrated our traditional­ Christmas Party at the “Aux Gazelles” in Vienna. Santa Claus gave his best and pleased all 26 children of the ­extended CeMM family. As in previous­ years, our second year PhD students arranged for the entertainment and – for the first time this year – they organized a charity tombola. Prizes consisted of fantastic activities with sometimes cryptic names such as Hot Air, Blue Note, Chameleon, Crosstrainer, or Meet&Greet and were exclusively donated by CeMMies.­ The tombola­ ­tickets were sold out ­quickly, and the amount of 1,010 Euro was handed over to the Sterntalerhof.­ Later in the evening ­CeMMies were thrilled by Undead, Ghosts a very ­special music guest: and Wonderland­ ­Diploma student Udo Following tradition,­ the ­Richson and his brother’s first year’s ­students are band rocked the dance in charge of ­organizing floor. the ­Halloween ball. The ­committee met twice a week to ensure perfect­ entertainment­ and an extensive­ supply­ of food and drinks. The party guests ­enjoyed a ­spectacular dance performance and an award ceremony,­ and ­demon­strated their ­incredible talents in front of our expert jury as part of an acting ­contest. The theme “Rocky Horror­ Picture Show” was ­accompanied by a heart- warming piece of music, the lyrics of which were inspired by the life of a PhD student. Among the guests: Andy Warhol and his famous painting, Alice in ­Wonderland, the English royal family, vampires, skeletons and many more. Good Scientific Interacting with Stakeholders

­Citizenship Her Britannic Majesty’s Ambassador to the Jochen Taupitz, an expert in Medical Ethics, Republic of Austria and the UK Permanent Giulio Superti-Furga moderated the breakout Representative to the United Nations in working group “Creating Knowledge: The Clearly CeMM’s future vision is one that encompasses a whole Vienna, Susan le Jeune d’Allegeershecque and freedom of research”. In his opening statement, new perception of the importance of molecular medicine in the her ­delegation visited us on April 14th, 2013. Giulio emphasized that demographic develop- ­Stefan Kubicek gave a lecture on “Epigenetics for ments and emerging diseases require dedicated 3rd millennium at the interface with society. CeMM promotes a new Type 1 ­Diabetes: Making new insulin ­producing funding for medical research. The existing and different awareness about the uniqueness of people’s genomic beta cells”– a dynamic discussion developed scientific ­expertise in infections, cardiovascular identity, the chances of personalized and preventative medicine, and ­afterward. Stefan Kubicek’s lab is supported­ and ­metabolic ­diseases, as well as cognitive, in part by the Juvenile Diabetes Research psychiatric and neurological disorders in Austria, the advocacy of a new responsibility of society towards biomedical ­Foundation ­Canada, which – overall supports represents a strong strategic value. To this effect, research and, symmetrically, of research towards society. Real research ­projects in over 17 nations, including Giulio Superti-Furga proposed a dedicated health ­scientific competence at the international level, measured by the United Kingdom. science research model, to complement basic research funding programs, in the style of an ­traditional bibliometric parameters but also by altmetric views, that On April 14th, 2013, Life Science Austria Austrian “National Institute of Health”. include originality of thought, outreach, education, training, patents, (LISA) arranged for researchers and biotech commercialization and medical impact, represent the earnestness ­representatives from Luxembourg to visit CeMM. On October 29th, 2013, we were honored by This ­important visit took place in the course of a visit from the new Board of the Austrian and credibility that CeMM aspires to. a state visit by the Grand Duke and the Grand ­Academy of Sciences, President Anton Zeilinger Duchess of Luxembourg, under­­scoring and and Vice-President Michael Alram. Giulio ­supporting their continuing venture to establish­ Superti-Furga gave a general introduction on Luxembourg as a European Biotech­nology hot- the research strategy at CeMM followed by three spot. short ­presentations by Sylvia Knapp, Robert Kralovics and Christoph Bock. To round up their The European Forum Alpbach is an interna- first official visit to CeMM, President Zeilinger Openness and Accountability tional discussion platform attracting politicians, and Vice-President Alram received a special scientists, business people, decision makers tour of CeMM, including our PLACEBO lab, the and students alike, that convene each summer Mass Spectrometry unit as well as the Next-­ in the Tyrolean village of Alpbach. A special Generation Sequencing Facility. The level of financial support, the visibility of the rounds, think rooms, art projects) but also symposium, dedicated to health-related topics CeMM building with its beautiful art facade, and popular ­lectures (Landsteiner Lectures, SMART took place from August 16th to 19th 2013, and CeMM’s research themes and successes represent Lectures) and sociological, ethical and health- focused on the question “Who Decides Health”. a new paradigm in terms of social contract and political debates. The quests we pursue are too CeMM’s Scientific Director Giulio ­Superti-­Furga transparency between a research institution and important and too close to the key interests of was invited to chair the discussion “Fair its stakeholders, the taxpayers, the patients and humankind to be tackled by biomedical research- ­Society, Healthy Lives” following the keynote the government. A good example is the yearly ers in ­isolation. To shape a better, worthwhile ­presentation by Sir Michael Gideon Marmot, the CeMM Research Report, which is more than a future we need to elaborate a common vision, be Professor of Epidemiology and Public Health at summary of the ongoing projects and activities. aware of what is at stake and take on challenges the ­University College London. Giulio also led It attempts to address a wider public of culturally with commitment and c­ourage. a plenary interview with John P. A. Ioannidis, interested people by providing interesting artistic the Professor of Health Research and Policy at insights and provoking new questions. Being Stanford School of Medicine, on “How Reli- aware of the potential impact of the ­scientific able is Evidence in Medicine”. Together with work on society, CeMM is fostering­ a seriously- meant yet playful and open exchange with the public, emphasizing science and art projects­ (art façade, special encounters and discussion

Ce — M­—M­— Research Report 2013 Life 95 96 Interacting with the Research Report and Brain Lounge Local Scientific Community

On May 15th, 2013 we hosted and launched our 2013 also included as a highlight two of the so- annual Research Report 2012 that introduced called “thinking rounds” in our Brain Lounge. CeMM’s research attitude takes a ­cooperative The Medical University of Vienna is CeMM’s the CeMM Brain lounge to a wider audience. ­Scheduled one year after the official opening mindset into consideration by fostering a highly most important partner, and the home academic This year joining us were the Austrian­ Academy of the Brain Lounge on December 16th, an collaborative, open-minded and interactive institution of its Ph.D. Program, but CeMM also of Science’s newly appointed ­Vice-President inspiring evening took place on December research strategy. We work beyond boundaries­ has numerous personal and institutional ties Michael Alram and Georg ­Brasseur the ­President 16th that fostered the interaction between Art, of labs and departments to educate and encour- to the more basic research institutions at the of the Mathematics and Natural ­Sciences Science and Society. The quantum physicist age our students to follow this path. Our research Vienna Biocenter, most notably IMBA (Institute division. Also, joining us from the ­Medical Markus Aspelmeyer from the ­University of facilities are strategically and conveniently­ of Molecular Biotechnology), IMP (Institute ­University of Vienna was Christiane Druml, Vienna chaired one ­session ­entitled “Paradoxes located in the heart of the campus of the Medical of Molecular Pathology) and the Max Perutz Vice-Rector for Clinical Affairs and Chair of the of ­physics of atoms”. The ­second discussion University of Vienna and the Vienna General ­Laboratories. Austrian Bioethics Commission. Other guests round was chaired by CeMM’s­ Christoph Bock, Hospital, a leading European medical research included Peter Pakesch, the Executive-Director of and was dedicated to the ­important topic “the and training center. We are privileged to On May 16th, 2013, organized by CeMM PI Joanneum Universal Museum, in Graz, and our meaning of human ­genomes for science and closely interact and collaborate with a number Andreas Bergthaler and a team from the ­Institute befriended artists Peter Kogler, ­Martin Walde, ­society”. Although some questions such as the of ­accomplished scientists and ­clinicians from of Science and Technology (IST Austria), a dele­ Dorothee Golz, Iris ­Ranzinger, Karl Emilio ­impossibility of beer-teleportation remained the Medical University of Vienna. To nurture gation from CeMM visited IST Austria at their Pircher and Fidel Peugeot. unanswered, all ­participants felt enlightened by an open and integrative atmosphere, we jointly beautiful institute just outside of Vienna. Our the newly obtained knowledge. organize quarterly get-togethers with the neigh- host, President Thomas A. ­Henzinger, joined the boring Anna Spiegel Research Building­ of the scientific presentations and discussions, which Medical University of Vienna.These events were followed by a social program. We have ­consist of scientific presentations, followed by ­current collaborative ventures with IST Austria social get-togethers. Some 80 people from CeMM and look forward to a long relationship. As a Excursion to Mauthausen and Anna Spiegel join each of these events, which show of friendship, CeMM presented President so importantly foster interactions and build a ­Henzinger and his staff with an original print foundation of trust. from Peter Kogler, representing the graphical ­elements ­portrayed by CeMM’s glass façade. On October 4th, 2013, CeMM committed its installed showrooms and a micro-cinema. In 1911 yearly excursion to the 75th anniversary of the the founders donated the Biologische Versuchs­ “Anschluss” to Nazi Germany in 1938. Starting anstalt to the Austrian Academy of Sciences­ at the festive hall of the Austrian Academy of to ensure its future. With the “Anschluss” of Sciences, President Anton Zeilinger welcomed ­Austria to Nazi-Germany in March 1938, the Interacting with Students and Pupils us and joined us for a lecture given by the institute was “aryanized” by the Nazis. Hans journalist and historian Klaus Taschwer on the Leo Przibram had to flee the country and he died “Biologische Versuchanstalt”. The “Biologische in the KZ Theresienstadt in 1944. The building Versuchsanstalt” was a pioneering Viennese was bombed in World War II and was never In April 2013, CeMM in conjunction with and Kaan Boztug provided an overview about Institute of Experimental Biological Research, restored. Christine Mannhalter, the Vice-President of the CeMM’s research. The lively and interactive visit privately founded in 1902 by the Jewish scientists Austrian Science Fund (FWF) and Professor of quickly developed into discussions about scien- and philanthropists Hans Leo Przibram, Leopold Our subsequent visit to the concentration camp Molecular Diagnostics hosted thirty pharma­ tificeducation’s ­ importance as a gatekeeper from von Portheim und Wilhelm Figdor. Hans Leo Mauthausen sparked a new type of ­discussion ceutical students from The Netherlands. With prejudices that are so often built on missing Przibram led the institute in an unprecedented,­ at CeMM and reawakened our ­awareness about the help of our students, this interesting day pro- knowledge. The students then visited Kaan visionary manner. Their mission was to ‘address the importance of ­safeguarding key values vided interdisciplinary insights into the research ­Boztug’s lab, where our students had prepared for global questions of biology’, rather than that should go hand in hand with the research ­performed in Vienna. We were truly impressed some hands-on experiments. The feedback of the ­tackling individual problems, and they did so by endeavors of an international, inclusive and by the Dutch students and the vivid and eloquent class: The visit was the highlight of their project; ­combining scientists from different disciplines, democratic ­science community. discussions that evolved. We profited from this the students felt well cared for and they devel- such as biology, botany, chemistry and physics. event, and hope the same for our visitors. oped a keen interest in science. This was an unparalleled strategy at this time and attracted international attention. Adding to their Four Austrian schools participated in a project­ On December 19th, 2013, we celebrated our function as role models for modern science, the called “Next Nature”, a philosophical concept­ ­traditional Christmas Party. Our ­second researchers even embodied scientific citizenship that was introduced by the Dutch artist, phi­ year Ph.D. students arranged for the first as they opened their doors to the public and losopher and scientist Koert van Mensvoort. time a ­charity-tombola in support of the The ­project encompasses all changes and develop- “­Sterntalerhof”, a children’s hospice where ments of nature since the e­xpanding influence of families can find peace and re-build their inner humanity on earth. We had the privilege of host- strength. The creativity and enormous efforts ing the Viennese Gymnasium­ Maria Regina’s in organizing this (especially Katrin Hörman 7th class, on May 27th, 2013. Giulio Superti-Furga and Bernd Boidol) was truly amazing.

Ce — M­—M­— Research Report 2013 Life 97 98 Research Report 2012 Welcome to CeMM On May 15th, 2013, some On October 29th, 2013, 50 people joined the CeMM was honored with presentation of CeMM’s a visit from President Research Report 2012. ­Anton Zeilinger and Vice- President Michael Alram.

Visit to ISTA Science and Diplomacy On May 16th, 2013 a Her Britannic Majesty’s­ delegation­ of CeMM visited ­Ambassador to the IST Austria. Giulio Superti- Republic­ of Austria Furga presented President and the UK Permanent­ Henzinger with a print Representative­ to (graphical elements of the United Nations in the CeMM facade) by Peter ­Vienna, Susan le Jeune Kogler. d’Allegeershecque and her delegation visited CeMM on April 14th, 2013.

International European Forum Alpbach Interdisciplinary­ Giulio Superti-Furga Exchange moderated the break- In April 2013 students out working session of pharmacy from The “Creating­ Knowledge: Netherlands visited CeMM The ­freedom of research“ and the Anna Spiegel at the Health Symposium Research Building. of the ­European Forum ­Alpbach 2013.

Excursion to Mauthausen The excursion to the concentration camp rose awareness about the ­importance of safeguarding key values and solidarity.

Visit to CeMM within the “Next Nature” Project On May 27th, 2013, 25 pupils were invited to CeMM to get some insight into ­molecular medical research­ and hopefully some inspiration for a scientific career. PX88_neu PX82_neu PX71_neu PX7_neu frei_B frei_A PX97 PX96 PX95 PX94 PX93 PX92 PX91 PX89 PX87 PX86 PX85 PX84 PX83 PX81 PX79 PX78 PX77 PX76 PX75 PX74 PX73 PX72 PX69 PX68 PX67 PX66 PX65 PX64 PX63 PX62 PX61 PX59 PX58 PX57 PX56 PX55 PX54 PX53 PX52 PX51 PX49 PX48 PX47 PX46 PX45 PX44 PX43 PX42 PX41 PX39 PX38 PX37 PX36 PX35 PX34 PX33 PX32 PX31 PX29 PX28 PX27 PX26 PX25 PX24 PX23 PX22 PX21 PX19 PX18 PX17 PX16 PX15 PX14 PX13 PX12 PX11 PX9 PX8 PX6 PX5 PX4 PX3 PX2 PX1 PX9 PX8 PX7 PX6 PX5 PX4 PX3 PX2 PX1

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Einsatz_detail1nein1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Einsatz_detail1nein Einsatz_detail2Einsatz_Glas 1 1 Einsatz_detail2Einsatz_Glas Einsatz_detail2Einsatz_Metall1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Einsatz_detail2Einsatz_Metall Einsatz_detail2Einsatz_Mutation 1 1 1 1 Einsatz_detail2Einsatz_Mutation Einsatz_detail2Einsatz_NA 1 Einsatz_detail2Einsatz_NA Einsatz_detail2Einsatz_Plastik 1 1 1 Einsatz_detail2Einsatz_Plastik Einsatz_detail2Einsatz_Schaumgummi 1 1 Einsatz_detail2Einsatz_Schaumgummi Einsatz_detail2nein1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Einsatz_detail2nein IronieIronie1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 IronieIronie Ironienein1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Ironienein Biomorphbiomorph 1 1 1 1 1 1 1 1 1 1 Biomorphbiomorph Biomorphnein1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Biomorphnein Biomorph_detailbiomorph_andere 1 1 1 1 Biomorph_detailbiomorph_andere Biomorph_detailbiomorph_tailliert 1 1 1 1 1 1 Biomorph_detailbiomorph_tailliert Biomorph_detailnein1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Biomorph_detailnein Schnorchel_allgemeinnein1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Schnorchel_allgemeinnein Schnorchel_allgemeinSchorchel 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Schnorchel_allgemeinSchorchel Schnorchel_detail1nein1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Schnorchel_detail1nein Schnorchel_detail1Schnorchel_schmal 1 1 1 1 1 1 1 1 1 Schnorchel_detail1Schnorchel_schmal Schnorchel_detail1Schnorchel_Variation 1 1 1 1 1 1 1 1 Schnorchel_detail1Schnorchel_Variation Schnorchel_detail2nein1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Schnorchel_detail2nein Schnorchel_detail2Schnorchel_Aufsatz 1 1 Schnorchel_detail2Schnorchel_Aufsatz Schnorchel_detail2Schnorchel_Metall 1 Schnorchel_detail2Schnorchel_Metall Schnorchel_detail2Schnorchel_rund 1 1 1 1 Schnorchel_detail2Schnorchel_rund Schnorchel_detail2Schnorchel_schmal 1 1 1 1 1 1 1 1 1 Schnorchel_detail2Schnorchel_schmal DUO_GruppeDuo 1 1 1 1 1 1 1 1 1 1 DUO_GruppeDuo DUO_GruppeGruppe1 1 1 1 1 1 DUO_GruppeGruppe DUO_Gruppesingle1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 DUO_Gruppesingle Oeffnung_allgemeingeschlossene_Form1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Oeffnung_allgemeingeschlossene_Form Oeffnung_allgemeinHuelle 1 1 1 1 1 1 1 1 1 1 1 1 Oeffnung_allgemeinHuelle Oeffnung_allgemeinMutationA 1 Oeffnung_allgemeinMutationA Oeffnung_allgemeinMutationB 1 Oeffnung_allgemeinMutationB Oeffnung_detailgeschlossene_Form1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Oeffnung_detailgeschlossene_Form Oeffnung_detailHuelle_gefuellt 1 1 1 1 1 Oeffnung_detailHuelle_gefuellt Oeffnung_detailHuelle_leer 1 1 1 1 1 1 1 Oeffnung_detailHuelle_leer Oeffnung_detailMutationA 1 Oeffnung_detailMutationA Oeffnung_detailMutationB 1 Oeffnung_detailMutationB Formmerkmal2_Spoiler 1 1 1 1 Formmerkmal2_Spoiler FormmerkmalHoehle 1 1 FormmerkmalHoehle FormmerkmalKombination 1 FormmerkmalKombination FormmerkmalLoch 1 1 1 1 1 FormmerkmalLoch Formmerkmalmittiger_Einsatz1 1 1 1 1 1 1 1 1 1 Formmerkmalmittiger_Einsatz Formmerkmalnein1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Formmerkmalnein FormmerkmalVertiefung 1 1 1 1 1 1 1 FormmerkmalVertiefung HalbkugelHalbkugel 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 HalbkugelHalbkugel Halbkugelnein1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Halbkugelnein Gereihteinfach 1 1 1 1 1 1 1 1 1 1 Gereihteinfach Gereihtgereiht 1 1 1 1 1 Gereihtgereiht Gereihtnein1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Gereihtnein Konvexkonvex 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Konvexkonvex Konvexnein1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Konvexnein Konkavkonkav 1 1 1 1 Konkavkonkav Konkavnein1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Konkavnein Voluminoesflach1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Voluminoesflach Voluminoesflach.voluminoes 1 1 1 1 1 1 1 1 1 1 1 1 1 Voluminoesflach.voluminoes Voluminoesvoluminoes1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Voluminoesvoluminoes Oberflaecheglatt1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Oberflaecheglatt Oberflaechestruktur 1 1 1 1 1 1 1 1 1 Oberflaechestruktur StrukturMuta1 1 StrukturMuta1 StrukturMuta2 1 StrukturMuta2 StrukturMuta3 1 StrukturMuta3 Strukturnein1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Strukturnein StrukturNoppen 1 1 1 1 StrukturNoppen StrukturRillen 1 1 StrukturRillen Sockelnein1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Sockelnein SockelSockel 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 SockelSockel BeineBeine1 1 1 1 1 1 1 1 1 BeineBeine Beinenein1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Beinenein Zusatztitelja1 1 1 1 1 1 1 1 1 1 Zusatztitelja Zusatztitelnein 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Zusatztitelnein 0 4,6904 4,8990 5,0990 6 6,1644 5,0990 4,6904 5,0990 4,4721 5,2915 4,8990 5,0990 6 5,2915 6,7823 6,4807 6,3246 6,6332 6,6332 5,8310 6,4807 6,4807 6,1644 4,2426 5,0990 4 3,7417 4,8990 5,0990 5,4772 4,6904 6,1644 4,4721 6,3246 6,3246 6,1644 5,8310 5,6569 6,3246 6,6332 6,3246 4,4721 4 4,6904 4,8990 4,8990 4,8990 5,2915 5,2915 5,0990 4,8990 5,6569 5,2915 5,0990 6 6,3246 7,4833 6,3246 6 6,4807 6,7823 6,4807 4,5826 5,1962 5 5,2915 5,2915 5,0990 5,6569 5,4772 6,9282 6,4807 6,6332 6,6332 6,4807 6,5574 5,7446 4,5826 5,6569 5,6569 5,6569 5,6569 5,4772 5,0990 5,4772 6,1644 6 6,4807 6,7823 5,3852 5,4772 5,0990 5,8310 6,1644 6,0000 5,5678 5,5678 5 4,6904 0 4,2426 4,2426 5,4772 5,6569 4,2426 4 4,2426 4,4721 4,6904 4,4721 4,4721 4,8990 4,8990 6 5,8310 5,4772 5,6569 6 5,0990 5,4772 6 5,4772 3,1623 4 4,4721 5,0990 4,8990 4,4721 4,4721 4,2426 5,0990 4 5,6569 5,6569 5,4772 5,0990 5,0990 5,2915 5,8310 5,6569 4,6904 4,4721 4,4721 4,8990 4,4721 4 4,2426 4,6904 4,8990 4,4721 4,2426 4,2426 4,2426 5,0990 5,2915 6,6332 5,2915 5,6569 5,8310 5,8310 6 4,7958 4,5826 4,5826 5,2915 5,0990 4 4,8990 4,6904 6,3246 5,2915 6 6 6,1644 5,9161 5,7446 4,3589 5,0990 5,0990 5,2915 4,6904 4,2426 4,4721 4,4721 4,8990 5,0990 5,8310 6 4,7958 4,8990 5,2915 4,8990 4,6904 4,4721 4,7958 4,3589 4,5826 4,8990 4,2426 0 4,4721 5,0990 5,0990 4 4,2426 4,2426 4,4721 2 3,1623 4 4,8990 5,0990 5,8310 6 5,2915 5,8310 5,8310 4,8990 5,2915 5,6569 5,2915 4,6904 3,7417 4,4721 4,2426 4 3,1623 3,7417 4,4721 4,6904 4 5,4772 5,4772 5,6569 4,6904 4,8990 5,4772 5,6569 5,2915 4,8990 4,6904 4 5,0990 4,8990 4,2426 4,8990 5,0990 4,4721 4 3,7417 4,6904 5,0990 4,6904 6 6,6332 5,6569 4,8990 5,2915 6 5,4772 4,5826 4,7958 4,5826 5,8310 5,6569 4,8990 4 4,8990 6 5,8310 5,4772 5,6569 5,8310 5,5678 5,5678 5,3852 5,4772 5,2915 5,2915 4,2426 4 5,4772 4,2426 5,4772 5,0990 5,6569 5,8310 4,5826 5,0990 5,2915 4,6904 5,4772 5,2915 4,7958 4,7958 4,7958 5,0990 4,2426 4,4721 0 5,0990 5,0990 3,1623 4,4721 4,4721 5,0990 4,8990 4,8990 4,4721 4,4721 2,8284 5,8310 6 5,4772 5,8310 5,8310 4,2426 4,8990 5,4772 4,6904 4,6904 4,8990 5,2915 5,4772 5,6569 5,0990 5,2915 4,6904 4,6904 4,6904 5,4772 5,4772 5,6569 3,7417 4,8990 4,8990 5,2915 4,8990 5,0990 4,8990 5,0990 6 5,8310 5,0990 4,6904 5,2915 4,8990 5,4772 5,4772 5,4772 4,6904 3,7417 5,0990 6,7823 6 4,6904 4,8990 5,6569 5,4772 5 5,1962 4,7958 6,1644 5,8310 4,8990 5,6569 5,6569 5,6569 5,6569 5,6569 5,2915 5,4772 5,5678CeMM6,2450 Research5,1962 Report6 6,16442013 6,1644 5,4772 5,2915 5,6569 5,2915 5,8310 5,8310 5,2915 5,4772 5,5678 6 6,1644 5,6569 5,8310 5,6569 5,7446 5,1962 5 6 5,4772 5,0990 5,0990 0 2,8284 4,4721 5,4772 5,8310 6 5,4772 5,2915 5,0990 5,4772 5,6569 4,2426 4 4,4721 4 4 4,6904 5,2915 5,6569 5,0990 5,8310 5,2915 5,6569 5,8310 6 5,6569 5,6569 5,8310 5,6569 5,8310 4,4721 4,4721 3,7417 5,2915 4,6904 5,0990 5,4772 5,0990 6,1644 6 5,4772 6,3246 6,1644 5,4772 5,8310 5,8310 5,6569 5,8310 5,8310 6,4807 6 5,4772 4,2426 4,8990 5,6569 4,6904 4,8990 5,2915 4,8990 5,3852 6,0828 5,3852 6,9282 6,6332 5,8310 6 6,1644 5,6569 6,1644 5,6569 5,0990 5,6569 5,5678 6,5574 6,4031 5,6569 6 6 5,0990 5,0990 6 5,0990 6,3246 5,4772 5,0990 5,0990 5,1962 5,8310 6 5,2915 6,1644 6 5,3852 6,0828 5,7446 6,1644 5,6569 5,0990 5,0990 2,8284 0 4,6904 5,6569 5,8310 6,1644 5,4772 5,4772 5,2915 5,6569 5,6569 3,4641 3,4641 4,8990 3,4641 3,4641 4,8990 5,2915 5,8310 5,2915 6 5,4772 5,8310 6 6,1644 5,6569 5,8310 6 5,8310 6 4,2426 4,2426 4,6904 5,2915 4,8990 5,2915 5,6569 4,8990 6,3246 6,1644 5,6569 6,4807 6,3246 5,6569 6 6 5,6569 6 6 6,6332 6,1644 5,4772 5,0990 5,4772 5,8310 4,8990 4,8990 5,2915 5,2915 5,5678 6,2450 5,5678 7,0711 6,7823 6 6,1644 6,3246 5,8310 6,3246 5,6569 5,2915 5,8310 5,7446 6,7082 6,5574 5,8310 6,1644 6,1644 5,4772 5,2915 6,1644 5,2915 6,4807 5,8310 5,0990 5,2915 5,3852 6 6,1644 5,2915 6,3246 6,1644 5,5678 6,2450 6,0828 5,0990 4,2426 4 3,1623 4,4721 4,6904 0 4,4721 4,8990 4,8990 4,4721 4,2426 3,7417 3,1623 4 5,4772 5,2915 4,8990 5,0990 5,0990 2,8284 4,4721 4,6904 3,4641 4,8990 4,2426 4,6904 4,8990 5,0990 4,6904 4,6904 4,8990 3,4641 4,6904 4,8990 4,8990 5,0990 3,4641 4,2426 3,7417 4,2426 4,4721 5,2915 5,0990 4,2426 5,4772 5,0990 4,2426 4,6904 5,2915 4,4721 4,6904 4,8990 5,6569 4,6904 3,7417 5,4772 6,3246 5,6569 4 4,4721 5,0990 4,6904 4,1231 5 3,8730 6 5,6569 4,6904 5,0990 5,6569 5,0990 5,4772 4,8990 4,6904 4,4721 4,7958 5,5678 5,3852 5,2915 5,4772 5,6569 4,8990 4,4721 5,4772 4,6904 5,8310 5,2915 4,6904 4,8990 5 5,2915 5,6569 5,0990 5,6569 5,4772 5,1962 5 5 4,6904 4 4,2426 4,4721 5,4772 5,6569 4,4721 0 2,4495 4 3,7417 3,4641 3,4641 4,6904 4,2426 5,6569 5,6569 5,0990 5,4772 5,4772 4,4721 5,2915 5,2915 4,8990 4,2426 3,7417 4,6904 4,4721 5,0990 4,2426 4,2426 3,7417 5,0990 4,2426 5,0990 5,0990 5,4772 4,6904 4,6904 5,2915 5,6569 5,0990 4,2426 4,2426 4 4,8990 5,0990 4 4 4,4721 4,6904 4,4721 4,4721 4,6904 4,4721 4,8990 5,2915 6,6332 5,2915 5,0990 5,8310 5,8310 5,4772 4,7958 5 4,7958 5,6569 5,6569 4,2426 4,6904 4,8990 6,3246 5,4772 5,4772 6 6,1644 5,3852 5,9161 4,5826 5,2915 5,0990 5,0990 4,4721 4,6904 4,8990 4,2426 5,0990 5,2915 5,8310 5,6569 4,3589 5,2915 5,4772 4,8990 5,0990 5,2915 5,1962 4,7958 4,5826 5,0990 4,2426 4,2426 4,4721 5,8310 5,8310 4,8990 2,4495 0 4 3,7417 3,4641 4 5,0990 4,2426 5,8310 6 5,0990 5,8310 5,8310 4,8990 5,2915 5,6569 5,2915 4,4721 4,0000 5,0990 4,8990 5,2915 4,2426 4,4721 3,7417 5,4772 4,2426 5,4772 5,4772 5,8310 4,8990 5,0990 5,6569 6 5,2915 4,6904 4,6904 4,4721 5,2915 5,4772 4,4721 4,2426 4,4721 4,6904 4,6904 4,6904 4,2426 4,4721 4,6904 5,4772 6,9282 5,4772 5,2915 5,8310 6,1644 5,8310 5,1962 5 5,1962 5,4772 5,6569 4,2426 4,8990 4,4721 6,6332 5,2915 5,8310 6,3246 6,4807 5,9161 6,2450 4,7958 5,6569 5,4772 5,4772 4,6904 4,8990 4,8990 4,2426 4,8990 5,6569 6,1644 6 5 5,6569 5,8310 5,4772 4,6904 4,8990 5,5678 4,7958 5,0000 4,4721 4,4721 4,4721 5,0990 6 6,1644 4,8990 4 4 0 4 3,7417 4,2426 5,0990 4,8990 6,1644 6 5,6569 5,8310 5,8310 4,8990 5,8310 5,8310 5,2915 4,8990 4,4721 4,4721 3,4641 4,2426 4,4721 4,4721 4,2426 5,0990 4 5,8310 5,8310 6 5,2915 5,2915 5,6569 6 5,8310 5,2915 5,0990 4,4721 4,8990 4,8990 4,4721 4,4721 4,6904 4,4721 3,4641 4,6904 4,6904 4,6904 5,2915 5,8310 7,0711 5,6569 5,6569 6,3246 6,3246 6 5,1962 4,5826 5,1962 4,6904 4,8990 4,2426 4,6904 4,6904 6,7823 5,8310 6,1644 6,4807 6,4807 6,0828Science6,2450 5 4,8990 4,8990 5,0990 5,0990 5,0990 3,7417 4,8990 5,4772 5,8310 6,4807 6,3246 5,1962 5,0990 5,4772 5,6569 5,0990 5,2915 5,7446 4,7958 5,3852 5,2915 4,6904 2 4,8990 5,4772 5,4772 4,4721 3,7417 3,7417 4 0 2,4495 3,4641 4,4721 4,6904 5,4772 5,6569 4,8990 5,4772 5,4772 4,4721 4,8990 5,2915 4,8990 4,8990 3,4641 4,6904 4 4,2426 2,8284 3,4641 4,2426 4,4721 4,2426 5,2915 5,2915 5,4772 4,4721 4,6904 5,2915 5,4772 5,0990 5,0990 4,8990 3,7417 4,8990 5,0990 4 4,6904 4,8990 4,2426 3,7417 3,4641 4,4721 4,8990 4,4721 5,8310 6,4807 5,4772 4,6904 5,4772 5,8310 5,2915 4,7958 5 4,7958 5,6569 5,8310 4,6904 3,7417 4,6904 6,1644 5,6569 5,2915 5,8310 6 5,3852 5,7446 5,1962 5,2915 5,0990 5,0990 4 4,2426 5,2915 4 5,2915 5,2915 5,8310 5,6569 4,3589 5,2915 5,4772 4,8990 5,2915 5,4772 5 5 5 4,8990 4,4721 3,1623 4,8990 5,2915 5,4772 4,2426 3,4641 3,4641 3,7417 2,4495 0 3,1623 4,4721 4,6904 5,4772 5,4772 4,4721 5,2915 5,2915 4,2426 4,8990 5,0990 4,6904 4,6904 3,1623 4,4721 3,4641 4,2426 3,1623 3,1623 4,2426 4,4721 4,2426 5,0990 5,0990 5,2915 4,4721 4,2426 5,0990 5,4772 5,0990 5,0990 4,8990 3,7417 4,6904 5,0990 3,7417 4,4721 4,8990 4,2426 3,4641 3,4641 4,2426 4,8990 4,4721 5,6569 6,4807 5,2915 4,4721 5,4772 5,6569 5,2915 4,5826 4,7958 4,5826 5,6569 5,8310 4,4721 3,7417 4,4721 6,1644 5,4772 5,2915 5,8310 6 5,3852 5,7446 5 5,0990 5,0990 5,0990 4 4,2426 5,0990 3,4641 5,0990 5,0990 5,6569 5,6569 4,3589 5,2915 5,2915 4,8990 4,8990 5,0990 5 5 5 5,0990 4,4721 4 4,4721 5,0990 5,2915 3,7417 3,4641 4 4,2426 3,4641 3,1623 0 3,4641 4,2426 4,8990 5,2915 4,6904 5,0990 4,6904 3,7417 4,6904 5,0990 4,2426 4,6904 3,4641 4,2426 4,2426 4,8990 4 3,4641 4 4 4,6904 4,8990 4,8990 5,0990 3,4641 4 4,6904 5,0990 4,8990 5,0990 4,8990 3,7417 4,8990 5,0990 3,7417 4 4,6904 4 4,2426 4 5,0990 4,4721 4,2426 5,2915 6,3246 5,2915 4,4721 5,2915 5,4772 5,2915 4,3589 5 4,1231 5,6569 5,6569 4,2426 4,4721 5,2915 5,8310 5,4772 5,4772 5,4772 5,2915 5,3852Director’s5,1962 4,5826 Intro4,8990 5,0990 5,0990 4,2426 4,4721 5,0990 4 5,4772 5,0990 5,4772 5,2915 4,3589 5,2915 5,4772 4,4721 5,2915 5,4772 5 4,7958 4,7958 6 4,8990 4,8990 4,4721 5,4772 5,6569 3,1623 4,6904 5,0990 5,0990 4,4721 4,4721 3,4641 0 4,2426 4,8990 5,0990 5,0990 4,8990 4,8990 3,1623 4,4721 4,8990 3,7417 5,2915 4,2426 5,0990 5,2915 5,2915 4,6904 4,4721 5,0990 2 5,2915 5,2915 5,2915 5,0990 3,1623 4,4721 3,7417 4,2426 4,6904 5,8310 5,6569 4,4721 5,2915 5,2915 4,2426 4,8990 5,2915 4,4721 4,6904 4,6904 5,4772 4,8990 4 5,2915 6,3246 5,6569 4,4721 5,0990 5,0990 4,8990 5 5,7446 4,7958 5,8310 6 4,6904 4,8990 5,4772 5,4772 5,2915 5,0990 5,0990 4,6904 4,7958 5,7446 5,3852 5,2915 5,2915 5,4772 4,6904 4,6904 5,4772 4,6904 5,6569 5,6569 4,8990 4,6904 4,7958 5,4772 5,8310 4,8990 5,6569 5,8310 5,3852 5,3852 5,3852 5,2915 4,8990 5,0990 2,8284 5,6569 5,6569 4 4,2426 4,2426 4,8990 4,6904 4,6904 4,2426 4,2426 0 5,6569 5,4772 5,2915 5,6569 5,6569 4 4,6904 5,2915 4,4721 5,0990 4,8990 5,2915 5,0990 6 4,6904 5,2915 4,2426 4,6904 4,6904 5,4772 5,4772 5,2915 3,7417 4,8990 4,8990 5,2915 4,8990 5,0990 4,8990 5,0990 5,6569 5,8310 4,6904 4,6904 4,8990 4,8990 5,4772 5,4772 5,0990 4,2426 3,7417 5,0990 6,7823 6 4,6904 5,2915 5,6569 5,4772 5 5,5678 5,1962 5,8310 5,8310 4,4721 5,6569 5,2915 6 5,6569 5,6569 5,6569 5,4772 5,5678Discussion6,2450 4,7958 on6 Art6,1644 and6,1644 Science5,4772 5,6569 5,6569 5,2915 5,8310 6,1644 5,6569 5,4772 5,1962 6,3246 6,1644 6 5,8310 6 5,7446 5,5678 5 6,7823 6 5,8310 5,8310 4,2426 3,4641 5,4772 5,6569 5,8310 6,1644 5,4772 5,4772 4,8990 4,8990 5,6569 0 3,1623 4,8990 2,4495 2,4495 4,8990 5,0990 5,8310 5,2915 6,1644 5,2915 6 6,1644 6,3246 5,4772 5,4772 6,1644 5,2915 6,4807 4,2426 4,2426 4,6904 4,8990 4,8990 5,0990 5,6569 4,8990 6,7823 6,6332 5,8310 6,3246 6,4807 5,4772 6 6 5,4772 5,8310 5,8310 6,4807 6,3246 5,4772 4,8990 5,6569 5,6569 5,0990 5,2915 5,0990 5,4772 6,0828 6,7082 6,0828 6,9282 7,0711 5,8310 6 6,1644 6,1644 6,1644 5,6569 5,6569 6 5,7446 6,8557 6,4031 5,6569 6 6 5,2915 5,4772 6 5,0990 6,3246 6 5,2915 5,0990 5,1962 6,1644 6,3246 5,0990 6,1644 6,3246 5,7446 6,5574 6,4031 6,4807 5,8310 6 6 4 3,4641 5,2915 5,6569 6 6,0000 5,6569 5,4772 5,2915 5,0990 5,4772 3,1623 0 4,8990 2 2,8284 4,6904 5,2915 5,8310 5,0990 6,1644 5,2915 5,6569 5,8310 6,3246 5,2915 5,6569 5,8310 5,4772 6 4,4721 4,4721 4 5,4772 4,8990 4,8990 5,4772 5,0990 6,4807 6,3246 5,6569 6 6 4,8990 6 5,6569 5,6569 5,6569 5,8310 6,1644 5,8310 5,6569 4,8990 5,4772 5,4772 5,0990 5,4772 5,0990 5,4772 5,5678 6,5574 5,9161 6,4807 6,6332 5,2915 6 5,6569 6,1644 6 5,6569 5,6569 5,8310 5,7446Science6,7082 6,2450at CeMM5,4772 5,8310 6 5,2915 5,2915 5,8310 5,0990 6,1644 6 5,2915 5,0990 4,7958 6 6 5,4772 6 6,1644 5,3852 6,5574 6,2450 6,3246 5,4772 5,2915 5,4772 4,4721 4,8990 4,8990 5,0990 5,0990 5,6569 4,8990 4,4721 4,6904 5,0990 5,2915 4,8990 4,8990 0 4,6904 4,6904 4,8990 4,2426 5,8310 5,2915 6 4,8990 5,8310 5,6569 6 5,2915 5,2915 5,6569 5,4772 6 4,2426 4,2426 4,2426 5,0990 5,2915 5,6569 6 5,6569 6,3246 6,1644 5,2915 5,8310 6 5,2915 5,6569 6,1644 5,2915 5,4772 5,0990 5,6569 5,4772 5,0990 4,8990 5,4772 6 4,8990 5,6569 5,6569 5,6569 5,5678 6,0828 5,3852 6,4807 6,6332 5,6569 5,6569 6,1644 6,3246 6,3246 6 6 6,4807 6,0828 6,5574 5,9161 6 6,1644 6,1644 5,4772 5,6569 6,1644 5,0990 6,3246 6,3246 6 5,8310 5,7446 6,3246 6,4807 6,1644 6 6,1644 6,0828 6,0828 5,7446 6,6332 5,6569 5,8310 5,8310 4 3,4641 5,0990 5,4772 5,8310 5,8310 5,4772 5,2915 5,0990 4,8990 5,6569 2,4495 2,0000 4,6904 0 2 4,4721 5,0990 5,6569 4,8990 6 5,0990 5,8310 6 6,1644 5,4772 5,4772 6 5,2915 6,1644 4 4 4,4721 5,2915 4,6904 4,6904 5,2915 4,8990 6,6332 6,4807 5,4772 6,1644 6,1644 5,0990 5,8310 5,8310 5,4772 5,4772 5,6569 6,3246 6 5,4772 4,8990 5,4772 5,2915 4,8990 5,2915 4,8990 5,2915 5,7446 6,4031 5,7446 6,6332 6,7823 5,4772 5,8310 5,8310 6 5,8310 5,4772 5,4772 6,0000 5,5678Cancer6,8557 6,4031 5,2915 5,6569 5,8310 5,0990 5,0990 5,6569 4,8990 6 5,8310 5,0990 4,8990 5 5,8310 6,1644 5,2915 5,8310 6 5,5678 6,4031 6,4031 6,6332 6 5,8310 5,8310 4 3,4641 5,0990 5,4772 5,8310 5,8310 5,4772 5,2915 4,6904 4,8990 5,6569 2,4495 2,8284 4,6904 2 0 4,4721 5,2915 5,6569 4,8990 6,3246 5,4772 6,1644 6 6,4807 5,8310 5,6569 6 5,2915 6,1644 4 4 4,8990 5,0990 4,8990 5,0990 5,4772 5,0990 6,6332 6,4807 5,4772 6,4807 6,4807 5,4772 5,6569 5,6569 5,8310 5,8310 6 6,6332 6 5,6569 5,0990 5,6569 5,6569 4,8990 5,4772 5,2915 5,2915 5,7446 6,4031 5,7446 6,9282 6,9282 5,8310 6,1644 6,1644 6,1644 6,1644 5,6569 5,6569 5,6569 5,7446 6,5574 6,0828 5,6569 6 6,1644 5,4772 5,4772 6 5,2915 6,3246 6,1644 5,4772 5,2915 5,3852 6,1644 6,4807 5,2915 6,1644 6,3246 5,9161 6,2450 6,2450 5,8310 5,0990 4,8990 4,2426 4,6904 4,8990 2,8284 4,4721 4,8990 4,8990 4,4721 4,2426 3,7417 3,1623 4 4,8990 4,6904 4,8990 4,4721 4,4721 0 4,4721 3,7417 2 5,4772 4,4721 5,2915 5,0990 5,6569 4,8990 4,8990 5,0990 3,7417 5,2915 5,0990 5,0990 5,2915 3,7417 3,7417 3,1623 3,7417 4 5,8310 5,6569 4,4721 5,6569 5,6569 4,4721 4,8990 4,6904 4,6904 4,8990 5,0990 5,8310 4,8990 4 5,6569 5,8310 5,2915 3,1623 4,4721 4,6904 4,2426 4,7958 5,5678 4,5826 6,1644 6,1644 4,8990 5,2915 5,0990 4,8990 5,0990 4,4721 4,6904 4,4721 4,3589Infectious6,0828 5,5678 Diseases4,8990 4,8990 5,0990 4,2426 4,2426 4,8990 4,0000 5,2915 5,0990 4,6904 4,4721 4,5826 5,0990 5,4772 5,0990 5,0990 5,2915 5,1962 5,5678 5,5678 6,4807 5,4772 5,2915 4,8990 5,2915 5,2915 4,4721 5,2915 5,2915 5,8310 4,8990 4,8990 4,6904 4,4721 4,6904 5,0990 5,2915 4,2426 5,0990 5,2915 4,4721 0 5,6569 4,8990 6 4,6904 5,8310 5,8310 6 5,0990 5,0990 5,8310 4,8990 6,1644 4,8990 4,8990 4,8990 4,0000 4,6904 5,0990 5,2915 4,6904 6,4807 6,3246 5,4772 5,8310 6 5,2915 5,8310 6,3246 4,8990 5,4772 4,8990 5,8310 5,4772 4 5,4772 5,8310 6 4,2426 4,4721 5,0990 5,4772 5,7446 6,2450 5,3852 6,3246 6,4807 5,6569 5,6569 6,3246 5,4772 6,3246 5,4772 5,0990 6,1644 5,5678 6,7082 6,0828 6 6,1644 6,1644 5,2915 5,4772 6,1644 5,2915 6,4807 6,3246 5,2915 5,0990 5,7446 6,3246 6,4807 6,1644 6,1644 6,3246 6,0828 6,2450 6,0828 6,4807 6 5,6569 5,4772 5,6569 5,8310 4,6904 5,2915 5,6569 5,8310 5,2915 5,0990 5,0990 4,8990 5,2915 5,8310 5,8310 5,8310 5,6569 5,6569 3,7417 5,6569 0 3,4641 6 5,2915 6 5,8310 6,3246 5,6569 5,6569 5,8310 5,2915 6,1644 6 6 6,1644 5,0990 5,0990 4,2426 4,2426 5,0990 6,4807 6,3246 5,4772 6,3246 6,4807 5,4772 6 5,6569 5,8310 5,8310 5,8310 6,3246 6,1644 5,2915 6,4807 4,8990 5,4772 4,6904 5,0990 5,0990 4 5,9161 6,5574 5,9161 7,0711 7,0711 6 6 6 3,7417 5,4772 4 4,6904 4,8990 4,1231Immune6,5574 6,4031 Disorders6 5,8310 and5,8310 Inflammatory5,0990 5,2915 5,8310 4,8990 Diseases5,2915 4,2426 5,4772 5,2915 5,3852 6 6,1644 5,8310 5,4772 5,6569 5,5678 6,4031 6,2450 6,1644 5,4772 5,2915 4,6904 5,0990 5,2915 3,4641 4,8990 5,2915 5,2915 4,8990 4,6904 4,2426 3,7417 4,4721 5,2915 5,0990 5,2915 4,8990 4,8990 2,0000 4,8990 3,4641 0 5,8310 4,8990 5,6569 5,4772 6 5,2915 5,2915 5,4772 4,2426 5,6569 5,4772 5,4772 5,6569 4,2426 4,2426 2,8284 4,2426 4,4721 6,1644 6 4,8990 6 6 4,8990 5,2915 5,0990 5,0990 5,2915 5,4772 6,1644 5,2915 4,4721 6 5,6569 5,0990 3,7417 4,2426 4,4721 4,6904 5,1962 5,9161 5 6,4807 6,4807 5,2915 5,6569 5,4772 4,6904 5,4772 4,8990 5,0990 4,8990 4,7958 6,4031 5,9161 5,2915 5,2915 5,4772 4,6904 4,6904 5,2915 4,4721 5,6569 4,8990 5,0990 4,8990 5 5,4772 5,8310 5,4772 5,4772 5,6569 5,5678 5,9161 5,9161 4,2426 3,1623 4,6904 4,6904 5,8310 6 4,8990 4,2426 4,4721 4,8990 4,8990 4,6904 4,6904 5,2915 5,0990 6,1644 6,1644 6 6 6,3246 5,4772 6 6 5,8310 0 4 4,4721 5,0990 4,8990 4,4721 4,4721 4,2426 5,2915 4,2426 5,8310 5,8310 5,6569 5,0990 5,0990 5,4772 6 5,6569 4,2426 3,7417 4,2426 5,4772 5,2915 4,4721 4,6904 5,0990 5,0990 4,8990 4,8990 4,6904 5,0990 5,2915 5,4772 7,0711 5,6569 5,8310 6 6,1644 6,1644 4,5826 4,5826 4,5826 5,8310 5,6569 4,4721 5,0990 5,0990 6,3246 5,6569 6,1644 6 6,4807 6,0828Post-Genomic5,7446 4,3589 5,6569 Technologies5,6569 5,6569 4,8990 4,6904 5,0990 4,6904 5,2915 5,2915 6 6,1644 5 5,4772 5,6569 5,0990 5,2915 5,0990 5,1962 5 5 5,0990 4 3,7417 4,8990 5,2915 5,4772 4,2426 3,7417 4 4,4721 3,4641 3,1623 3,4641 4,2426 4,8990 5,2915 5,2915 4,8990 5,0990 5,4772 4,4721 4,6904 5,2915 4,8990 4 0 3,7417 4 4 2,8284 2,4495 4 4,2426 4,4721 4,8990 4,8990 4,6904 4 4 4,4721 5,0990 4,6904 5,0990 4,8990 3,7417 4,4721 4,6904 3,1623 4,4721 4,8990 3,7417 3,4641 3,1623 4,4721 4,8990 4,2426 5,2915 6,3246 4,8990 4,6904 5,2915 5,2915 5,2915 4,5826 5,1962 4,5826 5,0990 5,6569 4 3,7417 4,6904 6 5,2915 5,0990 5,6569 6 5,1962 5,7446 5 4,6904 4,6904 4,6904 3,1623 3,4641 4,6904 3,1623 4,8990 4,6904 5,4772 5,2915 3,8730 4,8990 5,0990 4,4721 4,6904 4,8990 4,5826 5 5 4 4,4721 4,4721 5,2915 5,6569 5,8310 4,6904 4,6904 5,0990 4,4721 4,6904 4,4721 4,2426 5,0990 5,2915 6 5,6569 5,8310 5,8310 6,1644 5,2915 5,8310 6 5,6569 4,4721 3,7417 0 3,1623 3,7417 3,7417 4 4,2426 5,0990 4,4721 5,6569 5,6569 5,0990 4,8990 4,8990 5,2915 5,8310 5,4772 5,0990 4,8990 4,6904 3,7417 3,4641 3,7417 5,2915 5,2915 4,2426 4 4,4721 5,0990 5,2915 5,2915 6 6,9282 5,8310 5,6569 5,8310 6 6 4,5826 5,5678 5 4,8990 4,6904 4,4721 4,6904 5,2915 6,3246 6,1644 6 6 6 5,9161Diagnostics5,7446 5,3852 4,4721and 4,4721Therapeutics4,4721 4,6904 4,4721 4,6904 4,4721 5,8310 5,0990 5,8310 6 4,3589 4,2426 4 4,8990 5,6569 5,4772 4,5826 5,3852 5 3,7417 5,0990 4,2426 5,4772 5,8310 6 4,8990 4,4721 4,8990 3,4641 4 3,4641 4,2426 5,2915 5,0990 6,1644 5,8310 5,6569 6 6 5,0990 5,8310 5,8310 5,4772 5,0990 4 3,1623 0 3,7417 3,4641 4 4,2426 4,8990 4,2426 5,4772 5,4772 5,2915 4,8990 4,6904 5,4772 5,8310 5,4772 5,2915 5,0990 4,4721 4 4,4721 4 5,0990 5,0990 4,2426 3,4641 4,4721 4,8990 5,0990 5,2915 6,1644 6,9282 6 5,2915 6,1644 6,1644 5,8310 4,7958 5,3852 5,1962 4,8990 5,2915 4,6904 4,4721 5,0990 6,6332 6,3246 6 6,3246 6,1644 5,9161 5,9161 5,1962 4,8990 4,8990 4,8990 4,8990 5,0990 4,6904 4,6904 6 5,6569 6,1644 6,1644 4,5826 5,0990 4,6904 5,4772 5,8310 6 5,1962 5,5678 5,1962 4,8990 4,8990 4 5,6569 6 6,1644 5,0990 5,0990 5,2915 4,2426 4,2426 4,2426 4,8990 5,2915 6 6,3246 6,3246 6 6,1644 6,4807 5,6569 6 6,3246 6 4,8990 4 3,7417 3,7417 0 4 4 5,0990 4,8990 4,6904 6 6 5,8310 5,2915 5,2915 5,6569 6 5,8310 5,6569 5,4772 4,8990 4,6904 4,4721 4,6904 5,6569 5,8310 4 3,1623 4,2426 5,0990 5,8310 5,4772 6,3246 7,0711 6 5,8310 6 6,3246 6,1644 5,3852 5,5678 5,3852 5,2915 5,4772 5,2915 3,1623 5,2915 6,4807 6,1644 6,1644 6,1644 6,4807 6,0828Principal6,2450 6,0828 Investigators5,0990 4,8990 4,8990 4,6904 4,4721 4,8990 4,6904 5,8310 5,4772 6 6,1644 5 4,6904 4,8990 5,0990 5,8310 5,6569 5,1962 5,5678 5,5678 5,0990 4,4721 3,1623 5,0990 5,6569 5,6569 4,6904 4,2426 4,2426 4,4721 2,8284 3,1623 4 4,6904 4,6904 5,4772 5,2915 5,2915 5,4772 5,8310 4,8990 5,0990 5,6569 5,2915 4,4721 2,8284 3,7417 3,4641 4 0 2,8284 4 4,2426 4 5,2915 5,2915 4,6904 4,2426 4,4721 4,8990 5,4772 4,8990 5,0990 4,8990 4,2426 4,4721 4,6904 3,1623 4,8990 4,8990 4 3,4641 3,4641 4 4,8990 4,4721 5,6569 6,6332 5,2915 4,8990 5,4772 5,6569 5,6569 4,5826 5,1962 5 5,2915 5,6569 4 3,7417 4,2426 6,3246 5,6569 5,2915 6 6 5,5678 5,7446 5 5,0990 5,0990 5,0990 4 4,2426 5,0990 3,7417 5,2915 5,0990 5,8310 5,6569 3,8730 5,2915 5,0990 4,8990 5,0990 5,2915 4,5826 5,3852 5 5,4772 4,4721 3,7417 5,2915 5,6569 5,8310 4,6904 4,2426 4,4721 4,4721 3,4641 3,1623 3,4641 4,4721 5,2915 5,4772 5,6569 5,2915 5,4772 5,6569 4,8990 5,0990 5,6569 5,2915 4,4721 2,4495 4,0000 4 4 2,8284 0 4,2426 4 4,4721 5,2915 5,2915 5,0990 4,2426 4,4721 4,8990 5,4772 5,0990 5,4772 5,2915 4,2426 4,8990 5,0990 3,7417 4,4721 4,8990 4,2426 3,4641 2,8284 4,4721 5,2915 4,6904 5,2915 6,6332 5,2915 5,0990 5,6569 5,6569 5,6569 5,0000 5,1962 5 5,4772 6 4,4721 3,7417 4,6904 6,3246 5,6569 5,4772 6 6,1644 5,5678 5,9161 5,1962 5,0990 5,0990 5,0990 3,7417 4 5,0990 3,7417 5,2915 5,0990 5,8310 5,6569 4,3589 5,2915 5,4772 4,6904 5,0990 5,2915 5 5 5 4,6904 4,2426 4,4721 4,6904 5,8310 6 4,8990 3,7417 3,7417 4,2426 4,2426 4,2426 4 5,0990 4,2426 6,1644 5,8310 5,6569 6 6 5,0990 5,8310 5,8310 5,4772 4,2426 4 4,2426 4,2426 5,0990 4 4,2426 0 5,0990 3,1623 5,4772 5,4772 5,2915 4,8990 4,8990 5,4772 5,6569 5,4772 4,2426 4 4,2426 4,8990 5,0990 4 4,2426 3,1623 5,0990 4,8990 4,4721 4 3,7417 5,0990 5,4772 6,7823 5,6569 5,4772 6,1644 6,1644 5,6569 4,7958 5 5,1962 5,0990 5,0990 3,7417 4,8990 4,2426 6,4807 5,4772 6 6,1644 6 5,7446 5,7446 4,3589 5,6569 5,4772 5,4772 4,6904 4,8990 4,8990 4,6904 5,0990 5,6569 6,1644 6 4,3589 5,6569 5,4772 5,2915 5,0990 5,2915 5 4,5826 4,3589 6,1644 5,0990 4,6904 4,6904 5,6569 5,8310 3,4641 5,0990 5,4772 5,0990 4,4721 4,4721 4 2 4,6904 5,2915 5,4772 5,4772 5,2915 5,2915 3,7417 4,8990 5,2915 4,2426 5,2915 4,2426 5,0990 4,8990 4,8990 4,2426 4,0000 5,0990 0 4,8990 5,2915 5,2915 5,0990 3,1623 4,4721 3,7417 4,2426 4,6904 6 5,8310 4,6904 5,4772 5,4772 4,4721 5,0990 5,4772 4,6904 4,4721 4,4721 5,2915 5,0990 4,2426 5,4772 6,4807 5,8310 4,6904 5,2915 5,2915 5,0990 5,1962 5,5678 5 6 6,1644 4,8990 4,6904 5,2915 5,6569 5,4772 5,2915 5,2915 4,8990 5 5,9161 5,5678 5,4772 5,4772 5,6569 4,8990 4,8990 5,6569 4,8990 5,8310 5,8310 5,0990 4,8990 5 5,6569 6 5,0990 5,8310 6 5,5678 5,5678 5,5678 4,4721 4 4 4,6904 5,8310 6 4,6904 4,2426 4,2426 4 4,2426 4,2426 4,6904 5,2915 4,6904 6,4807 6 6 6,1644 6,1644 5,2915 6,1644 6,1644 5,6569 4,2426 4,4721 4,4721 4,2426 4,6904 4 4,4721 3,1623 4,8990 0 5,8310 5,8310 5,6569 5,2915 5,2915 5,6569 5,8310 5,8310 4,2426 4 4,4721 5,2915 4,8990 4,2426 4,4721 4 5,4772 4,6904 4,6904 3,7417 3,4641 5,4772 5,8310 7,0711 5,8310 5,8310 6,1644 6,4807 6 4,5826 4,3589 5 5,2915 4,8990 4 4,8990 3,7417 6,4807 5,6569 6,3246 6,1644 5,8310 6,0828 5,5678 4,5826Life5,8310 5,6569 5,8310 5,0990 4,6904 5,0990 5,0990 5,2915 5,6569 6,1644 6,3246 4,7958 5,4772 5,4772 5,2915 5,2915 5,0990 5 4,3589 4,3589 6,3246 5,6569 5,4772 5,4772 4,4721 4,2426 4,8990 5,0990 5,4772 5,8310 5,2915 5,0990 4,8990 5,2915 5,4772 4,2426 4,4721 4,2426 4 4 5,0990 4,8990 6,0000 5,4772 5,8310 4,8990 5,6569 5,4772 6 5,2915 5,2915 5,4772 5,2915 5,8310 0 0 3,7417 4,8990 5,0990 5,4772 5,8310 5,2915 6,1644 6,1644 5,2915 5,8310 6 5,2915 5,6569 6,1644 5,4772 5,6569 5,4772 6,1644 5,6569 5,2915 4,8990 5,6569 6,1644 5,0990 5,8310 5,4772 5,6569 5,5678 5,9161 5,1962 6,4807 6,4807 5,6569 5,8310 6,4807 6,3246 6,6332 6,1644 6 6,4807 6,0828 6,4031 6,0828 5,8310 5,8310 5,8310 5,6569 5,8310 6 5,4772 6,6332 6,3246 5,8310 5,6569 5,7446 6,1644 6,3246 6,1644 6,1644 6,3246 5,9161 6,0828 5,9161 6,3246 5,6569 5,4772 5,4772 4,4721 4,2426 4,8990 5,0990 5,4772 5,8310 5,2915 5,0990 4,8990 5,2915 5,4772 4,2426 4,4721 4,2426 4 4 5,0990 4,8990 6 5,4772 5,8310 4,8990 5,6569 5,4772 6 5,2915 5,2915 5,4772 5,2915 5,8310 0 0 3,7417 4,8990 5,0990 5,4772 5,8310 5,2915 6,1644 6,1644 5,2915 5,8310 6 5,2915 5,6569 6,1644 5,4772 5,6569 5,4772 6,1644 5,6569 5,2915 4,8990 5,6569 6,1644 5,0990 5,8310 5,4772 5,6569 5,5678 5,9161 5,1962 6,4807 6,4807 5,6569 5,8310 6,4807 6,3246 6,6332 6,1644 6 6,4807 6,0828 6,4031 6,0828 5,8310 5,8310 5,8310 5,6569 5,8310 6 5,4772 6,6332 6,3246 5,8310 5,6569 5,7446 6,1644 6,3246 6,1644 6,1644 6,3246 5,9161 6,0828 5,9161 6,1644 5,4772 5,6569 5,6569 3,7417 4,6904 5,0990 5,4772 5,8310 6 5,4772 5,2915 5,0990 5,0990 5,2915 4,6904 4 4,2426 4,4721 4,8990 5,2915 4,8990 6,1644 5,6569 5,6569 4,6904 5,0990 5,2915 5,8310 4,6904 5,0990 5,2915 5,0990 5,6569 3,7417 3,7417 0 4,8990 5,0990 5,2915 5,8310 5,4772 6,1644 6 5,4772 5,4772 5,6569 4,6904 5,8310 6 5,2915 5,4772 5,2915 5,6569 5,4772 5,2915 3,7417 5,0990 6 5,2915 5,8310 5,2915 5,6569 5,3852 6,0828 5,3852 6 6,1644 5,0990 5,6569 6,0000 6,3246 6,4807 6,1644 6 6,3246 6,0828 6,2450 5,9161Great5,6569 Lectures5,8310 5,8310 5,2915 5,6569 5,8310 5,2915 6,4807 6 5,8310 5,4772 5,1962 6,1644 6 6 6 6,1644 5,3852 6,2450 5,5678 5,8310 5,0990 4,6904 3,7417 5,2915 5,2915 3,4641 4,6904 4,8990 5,2915 4,4721 4,4721 3,4641 3,1623 3,7417 4,8990 5,4772 5,0990 5,2915 5,0990 3,7417 4,0000 5,0990 4,2426 5,0990 4 4,8990 4,8990 5,2915 4,2426 4,2426 4,8990 3,1623 5,2915 4,8990 4,8990 4,8990 0 3,7417 4 4,2426 3,7417 5,8310 5,6569 4,6904 5,4772 5,6569 4,4721 4,8990 5,4772 4,2426 4,8990 4,8990 5,6569 5,0990 2,8284 5,2915 6,1644 5,8310 4,2426 4,4721 5,0990 5,0990 5 5,7446 4,7958 6,1644 6 4,8990 5,0990 5,8310 5,2915 5,8310 4,8990 4,8990 5,0990 4,7958 5,9161 5,3852 5,4772 5,6569 5,6569 4,8990 5,0990 5,6569 4,6904 6 5,6569 5,0990 4,8990 5 5,8310 6 5,0990 5,8310 6 5,5678 5,5678 5,3852 5,6569 5,0990 4,8990 4,8990 4,6904 4,8990 4,2426 4,6904 5,0990 5,2915 4,6904 4,2426 4 4,4721 4,8990 4,8990 4,8990 5,2915 4,6904 4,8990 3,7417 4,6904 5,0990 4,2426 5,0990 4 4,8990 4,6904 5,2915 4,4721 4,4721 4,8990 4,4721 5,2915 5,0990 5,0990 5,0990 3,7417 0 3,7417 4 3,4641 5,8310 5,6569 4,6904 5,2915 5,6569 4,4721 5,0990 5,0990 4,4721 4,8990 4,8990 5,6569 5,0990 4,2426 5,6569 5,8310 5,0990 3,7417 4,2426 4,6904 4,8990 5 5,7446 4,7958 6,1644 6 4,8990 5,0990 5,2915 5,0990 5,0990 4,6904 4,4721 5,2915 4,5826 6,2450 5,7446Scientific4,6904 5,0990 5,0990Meetings4,2426 4,4721 5,0990 4,0000 5,4772 5,0990 4,4721 4,4721 4,1231 5,2915 5,2915 4,6904 5,2915 5,4772 4,7958 5,7446 5,5678 6,3246 5,2915 5,4772 4,8990 5,0990 5,2915 3,7417 5,2915 5,6569 5,6569 5,2915 5,0990 4,6904 3,7417 4,8990 5,0990 4,8990 5,6569 4,6904 5,0990 3,1623 5,0990 4,2426 2,8284 5,4772 4,4721 5,2915 5,4772 5,6569 4,8990 4,8990 5,4772 3,7417 5,6569 5,4772 5,4772 5,2915 4 3,7417 0 3,7417 4 6,3246 6,1644 5,0990 5,8310 5,8310 4,6904 5,4772 5,4772 4,8990 5,0990 5,2915 6,0000 5,4772 4,4721 5,8310 5,8310 4,6904 4,2426 3,7417 4 4,6904 5,3852 6,0828 5,1962 6,3246 6,4807 5,0990 5,4772 5,4772 4,8990 5,0990 4,6904 4,8990 4,8990 4,5826 6,5574 6,0828 4,8990 5,2915 5,4772 4,6904 4,6904 5,2915 4,4721 5,6569 4,8990 4,6904 4,4721 4,5826 5,4772 5,8310 5,0990 5,4772 5,6569 5,1962 6,0828 6,0828 6,6332 5,8310 5,6569 5,2915 5,4772 5,6569 4,2426 5,6569 6 6 5,4772 5,4772 5,0990 4,2426 5,2915 5,6569 5,4772 6,0000 5,2915 5,4772 3,7417 5,2915 4,2426 4,2426 6 5,0990 5,8310 5,8310 6 5,4772 5,4772 5,6569 4,2426 5,8310 5,8310 5,8310 5,8310 4,2426 4 3,7417 0 4,2426 6,4807 6,3246 5,2915 6,1644 6,1644 5,2915 5,8310 5,6569 5,4772 5,6569 5,6569 6,3246 5,6569 4,6904 6,3246 5,4772 5,4772 4,6904 4,8990 5,2915 3,4641 5,7446 6,4031 5,5678 6,6332 6,4807 5,6569 5,8310 5,8310 4,4721 4,2426 3,7417 3,1623 3,7417 3 6,0828 6,4031Great5,4772 Competitions5,6569 5,8310 5,0990 5,0990 5,8310 5,0990 4,8990 5,4772 4,4721 4,2426 5 5,8310 6,1644 5,4772 5,2915 5,4772 5,1962 6,2450 6,2450 6,3246 5,6569 5,2915 4,8990 5,0990 4,8990 4,4721 5,0990 5,2915 5,8310 5,0990 5,0990 4,8990 4,6904 4,8990 4,8990 5,0990 5,6569 4,8990 5,0990 4,0000 4,6904 5,0990 4,4721 5,6569 4,6904 5,4772 5,4772 5,8310 4,8990 5,0990 5,4772 4,6904 5,8310 5,2915 5,2915 5,4772 3,7417 3,4641 4,0000 4,2426 0 6 6,1644 5,2915 5,8310 6 5,0990 5,4772 5,6569 5,0990 5,4772 5,4772 6,1644 5,8310 4,2426 6 6,1644 5,6569 4,2426 4,2426 4,2426 4,8990 5,5678 6,2450 5,5678 6,6332 6,4807 5,4772 5,6569 5,8310 5,2915 5,8310 4,4721 4,6904 5,4772 4,5826 6,7082 6,2450 5,2915 5,4772 5,4772 4,8990 5,0990 5,6569 4,6904 6 5,6569 4,4721 4,2426 4,7958 5,6569 5,8310 5,0990 5,8310 6 5,3852 6,2450 6,0828 4,4721 4,6904 4,8990 5,0990 6,1644 6,3246 5,2915 4,2426 4,6904 5,2915 5,0990 5,0990 5,0990 5,8310 5,0990 6,7823 6,4807 6,3246 6,6332 6,6332 5,8310 6,4807 6,4807 6,1644 4,2426 5,0990 5,0990 5,2915 5,6569 5,0990 5,4772 4,2426 6 4,2426 6,1644 6,1644 6,1644 5,8310 5,8310 6,3246 6,4807 6 0 2,4495 4 5,2915 5,0990 4,6904 4,4721 4,6904 5,6569 5,4772 5,2915 4,8990 4,6904 5,6569 6 7,2111 6,1644 6 6,3246 6,6332 6,1644 4,3589 4,7958 4,7958 6 5,6569 4,8990 5,6569 5,2915 6,7823 6,1644 6,4807 6,4807 6,3246 6,2450 5,3852 4,5826Great6,3246 Celebrations6 6 5,4772 5,2915 5,8310 5,4772 5,8310 6 6,3246 6,4807 5 5,8310 5,6569 5,4772 6 5,8310 5,3852 5 4,5826 4 4,4721 4,6904 4,8990 6 6,1644 5,0990 4,2426 4,6904 5,0990 4,8990 4,8990 4,8990 5,6569 4,8990 6,6332 6,3246 6,1644 6,4807 6,4807 5,6569 6,3246 6,3246 6 3,7417 4,8990 4,8990 5,0990 5,4772 4,8990 5,2915 4 5,8310 4 6,1644 6,1644 6 5,6569 5,6569 6,1644 6,3246 6,1644 2,4495 0 4 5,2915 5,0990 4,4721 4,2426 4,4721 5,4772 5,2915 5,0990 4,6904 4,4721 5,4772 5,8310 7,0711 6 5,8310 6,1644 6,4807 6 4,3589 4,7958 4,7958 5,8310 5,4772 4,6904 5,4772 5,0990 6,6332 6 6,3246 6,3246 6,1644 6,0828 5,3852 4,1231 6,1644 6 6 5,2915 5,0990 5,6569 5,2915 5,6569 5,8310 6,3246 6,4807 4,7958 5,8310 5,6569 5,2915 5,8310 5,6569 5,1962 5 4,1231 4,6904 4,4721 4 5,0990 5,4772 5,6569 4,2426 4 4,4721 4,4721 3,7417 3,7417 3,7417 4,4721 5,0990 5,8310 5,6569 5,2915 5,4772 5,4772 4,4721 5,4772 5,4772 4,8990 4,2426 3,7417 4,6904 4,4721 4,8990 4,2426 4,2426 4,2426 4,6904 4,4721 5,2915 5,2915 5,4772 4,6904 4,6904 5,0990 5,2915 5,2915 4 4 0 4,6904 4,6904 3,4641 4,2426 4,4721 4,4721 4 4 4,8990 4,4721 4,6904 5,6569 6,3246 5,2915 4,8990 5,6569 5,6569 5,0990 3,6056 4,3589 3,6056 5,6569 5,6569 4,4721 4,4721 5,0990 6,1644 5,6569 5,6569 5,8310 5,8310 5,3852 4,5826 4,3589Good5,0990 Scientific4,8990 5,0990 4,2426Citizenship4,2426 5,0990 4,2426 5,2915 5,2915 5,8310 5,6569 4,3589 5,0990 5,4772 4,8990 5,2915 5,4772 5 4,7958 5 4,8990 4,8990 5,0990 6 6,3246 6,4807 5,4772 4,8990 5,2915 4,8990 4,8990 4,6904 4,8990 5,2915 5,6569 6,3246 6 5,8310 6,1644 6,4807 5,6569 5,8310 6,3246 6 5,4772 4,4721 3,7417 4 4,6904 4,4721 4,8990 4,8990 5,4772 5,2915 5,8310 5,8310 5,4772 5,4772 5,2915 5,8310 6,1644 5,8310 5,2915 5,2915 4,6904 0 2,4495 4 5,4772 5,2915 4,4721 4,2426 4,2426 4,6904 4,8990 5,4772 6,1644 6,6332 6 5,6569 6,3246 6 6 5,3852 6,0828 5,5678 5,0990 4,6904 4,8990 4,8990 5,4772 6,7823 6,3246 6,3246 6,4807 6,4807 6,0828 6,0828 5,3852 4,4721 4 3,7417 4,8990 5,0990 4,6904 4,8990 6 5,8310 6 6 4,5826 4 3,7417 5,4772 5,8310 6 5 5,7446 5,3852 4,8990 4,4721 4,8990 5,8310 6,1644 6,3246 5,0990 5,0990 5,4772 4,8990 5,0990 5,0990 5,0990 5,2915 5,8310 6,4807 6 6 6,1644 6,4807 5,6569 6 6,4807 6 5,2915 4,6904 3,4641 4,4721 4,4721 4,6904 5,0990 5,0990 5,4772 4,8990 6 6 5,6569 5,6569 5,6569 5,8310 6,1644 6 5,0990 5,0990 4,6904 2,4495 0 4 5,4772 5,2915 4,6904 4,2426 4,4721 4,8990 4,8990 5,6569 6,3246 6,7823 6 6 6,1644 6,1644 6,1644 5 5,7446 5,1962 5,0990 4,4721 4,8990 5,0990 5,4772 6,6332 6,3246 6,4807 6,3246 6,1644 6,2450 5,7446 5,3852 4,4721 3,7417 4,2426 5,0990 4,6904 4,6904 5,0990 6 5,6569 6 6,1644 4,7958 3,7417 3,4641 5,2915 5,8310 5,6569 4,7958 5,3852 5,1962 4,8990 4 4,2426 5,0990 5,4772 5,6569 4,2426 4 4,4721 4,4721 4 3,7417 3,7417 4,2426 4,6904 5,4772 4,8990 5,2915 5,0990 5,4772 4,4721 5,2915 5,4772 4,8990 4,4721 3,1623 3,7417 4 4,6904 3,1623 3,7417 4 4,4721 4,2426 5,2915 5,2915 4,6904 4,4721 4,4721 4,6904 5,2915 5,0990 4,6904 4,4721 3,4641 4 4 0 3,7417 4,2426 4 3,4641 3,7417 4,2426 4,2426 4,4721 5,2915 6,3246 4,8990 4,8990 5,4772 5,2915 5,2915 4,1231 4,7958 4,5826 4,6904 4,8990 2,8284 4,2426 4,4721 6,1644 5,4772 5,4772 5,8310 5,6569 5,3852 5 4,5826 4,2426 4,6904 4,8990 4 4 4,6904 3,7417 5,0990 4,8990 5,6569 5,4772 3,6056 4,8990 4,8990 4,6904 4,8990 5,0990 4,3589 4,5826 4,7958 5,2915 4,2426 4,8990 4,6904 5,8310 6 4,6904 4 4,2426 4,4721 4,6904 4,4721 4 4,8990 4,6904 6 6 5,6569 5,8310 5,6569 4,8990 5,8310 6 5,2915 4,6904 4,4721 5,2915 5,0990 5,6569 4,8990 4,4721 4,2426 5,0990 4,4721 5,6569 5,6569 5,8310 4,8990 5,0990 5,4772 5,8310 5,4772 4,4721 4,2426 4,2426 5,4772 5,4772 3,7417 0 4 4,8990 4,6904 4,8990 4,8990 4,2426 4,8990 4,8990 6,7823 5,2915 5,2915 6 6 5,8310 5 4,5826 5 5,2915 5,2915 3,7417 5,2915 5,0990 6,6332 5,4772 6,1644 6,3246 6,1644 6,0828 5,5678 4,5826 5,0990 5,6569 5,8310 5,0990 5,0990 5,0990 4,8990 5,2915 5,8310 6,3246 6,1644 5,1962 5,8310 6,1644 5,4772 5,2915 5,4772 5,7446 4,1231 4,5826 5,2915 4,6904 5,0990 5,2915 5,8310 6 5,2915 4,4721 4,4721 4,6904 4,8990 4,8990 4,6904 5,2915 4,8990 6 5,6569 6,1644 5,8310 5,6569 4,6904 6,3246 5,6569 5,0990 5,0990 4,8990 5,2915 5,0990 5,8310 4,8990 4,8990 3,1623 5,4772 4 6,1644 6,1644 6 5,4772 5,0990 5,4772 5,6569 5,6569 4,6904 4,4721 4,4721 5,2915 5,2915 4,2426 4 0 5,4772 5,0990 5,0990 4,4721 4 5,4772 5,4772 6,4807 5,2915 5,0990 6 6 5,4772 5,1962 5,3852 5,5678 5,4772 5,4772 4,2426 5,4772 3,7417 6,3246 5,2915 6 6,1644 5,6569 5,7446 5,9161 4,5826 5,4772 5,0990 5,2915 4,4721 4,4721 4,4721 4,4721 4,6904 5,4772 6,1644 6 4,3589 5,2915 5,2915 5,0990 4,6904 4,8990 5 4,5826 4,5826 5,0990 4,8990 4,4721 4,8990 5,6569 5,6569 4,4721 4,6904 4,6904 4,4721 4,2426 4,2426 4,0000 4,4721 4,8990 5,4772 5,6569 5,2915 5,4772 5,8310 4,6904 4,8990 5,8310 5,0990 5,0990 3,7417 4,2426 4,2426 4 4 4,2426 5,0990 4,6904 5,4772 5,4772 5,4772 5,2915 4,2426 4,4721 4,8990 5,4772 5,0990 5,6569 5,4772 4,4721 4,4721 4,6904 4 4,8990 5,4772 0 2,8284 4,2426 5,0990 4,6904 4 5,4772 6,4807 5,2915 4,6904 5,0990 5,4772 5,6569 4,7958 5,7446 4,5826 5,0990 5,6569 4,6904 4,4721 5,4772 6,1644 5,4772 5,6569 5,8310 6,1644 5,7446Facts6,2450 5,7446 4,6904 4,8990 4,8990 4,4721 4,6904 4,6904 4,2426 5,6569 5,4772 5,6569 5,4772 4,7958 5,0990 5,2915 5,2915 5,4772 5,6569 5,3852 5,7446 5,5678 4,8990 4,4721 4 5,4772 5,8310 6 4,6904 4,4721 4,6904 3,4641 3,7417 3,4641 4,2426 4,6904 5,4772 5,8310 5,6569 5,4772 5,4772 5,8310 4,8990 5,4772 5,8310 5,2915 4,8990 3,4641 4 3,4641 3,1623 3,4641 3,4641 4,8990 4,4721 4,6904 5,6569 5,6569 5,4772 4,8990 4,8990 5,0990 5,6569 5,4772 5,4772 5,2915 4 4,2426 4,2426 3,4641 4,6904 5,0990 2,8284 0 3,4641 4,4721 5,0990 4,6904 5,6569 6,6332 5,0990 5,0990 5,6569 5,6569 5,6569 5,0000 5,1962 5 4,8990 5,4772 4,4721 3,7417 4,6904 6,4807 5,6569 5,6569 6,1644 6,3246 5,7446 6,0828 5,3852 4,4721 4,4721 4,6904 4,2426 4,2426 4,2426 4 5,2915 5,2915 6 5,8310 4,5826 4,6904 5,0990 5,0990 5,0990 5,2915 5,1962 5,3852 5,5678 5,6569 4,2426 3,7417 5,4772 5,8310 6 4,8990 4,4721 4,6904 4,6904 3,4641 3,4641 4 4,6904 5,4772 5,8310 5,8310 5,0990 5,6569 6 5,0990 4,8990 5,8310 5,4772 4,8990 3,1623 4,4721 4,4721 4,2426 3,4641 2,8284 4,4721 4,4721 4,6904 5,4772 5,4772 5,2915 4,8990 4,8990 5,2915 5,6569 5,4772 5,2915 5,0990 4 4,2426 4,4721 3,7417 4,8990 5,0990 4,2426 3,4641 0 3,7417 4,6904 4,6904 5,6569 6,1644 5,2915 5,0990 5,6569 5,4772 5,4772 5,1962 5,1962 5 5,0990 5,8310 4,6904 3,7417 4,6904 6,3246 5,6569 5,6569 6 6,3246 5,5678 5,9161 5,1962 5,0990 4,8990 4,8990 3,4641 3,7417 5,0990 4 5,2915 5,2915 5,8310 5,6569 4,3589 5,0990 5,2915 4,8990 5,0990 5,2915 4,7958 5,1962 5,1962 p. 104 5,2915 4,2426 4,6904 5,4772 6,4807 6,6332 5,6569 4,6904 4,2426 4,6904 4,4721 4,2426 5,0990 5,4772 5,0990 6,4807 6,1644 5,6569 6,3246 6,6332 5,8310 5,8310 6,3246 6,1644 4,6904 4,4721 5,0990 4,8990 5,0990 4 4,4721 4 5,2915 3,7417 6,1644 6,1644 5,6569 5,6569 5,6569 6 6,3246 6,1644 4,8990 4,6904 4,8990 4,6904 4,8990 4,2426 4,8990 4,4721 5,0990 4,4721 3,7417 0 3,7417 5,2915 5,6569 6,7823 5,6569 5,8310 6,3246 6,1644 6,1644 5,5678 5,1962 5,7446 5,0990 5,4772 4,2426 4,6904 3,1623 6,7823 5,4772 6,3246 6,4807 6,6332 6,2450Scientific6,2450 4,7958 Advisory5,8310 5,6569 Board5,6569 4,8990 5,0990 5,0990 4,6904 5,0990 6 6,4807 6,3246 4,7958 5,8310 5,6569 5,6569 4,8990 5,0990 5,1962 5,1962 5 5,0990 4,2426 5,0990 4,6904 6 6,1644 4,6904 4,4721 4,4721 4,6904 4,8990 4,8990 4,4721 4,8990 4,2426 6,3246 5,8310 5,4772 6 6 4,8990 5,4772 6,1644 5,2915 5,0990 4,8990 5,2915 5,0990 5,8310 4,8990 5,2915 3,7417 5,0990 3,4641 5,6569 5,6569 5,4772 5,0990 5,0990 5,4772 5,6569 5,8310 4,6904 4,4721 4,4721 4,8990 4,8990 4,2426 4,2426 4 4,6904 5,0990 4,6904 3,7417 0 4,8990 5,4772 6,4807 5,6569 5,2915 6 6 5,8310 4,5826 5 4,5826 5,0990 5,0990 4 5,4772 4,4721 6,4807 5,2915 6,3246 6,1644 5,8310 6,0828 5,7446 4,3589 5,6569 5,6569 5,8310 5,2915 5,2915 5,0990 5,2915 5,4772 6,1644 6,1644 6 5 5,8310 5,8310 5,8310 5,2915 5,4772 5,3852 4,7958 4,5826 pp. 106—107 6 5,0990 4,6904 3,7417 5,4772 5,4772 3,7417 4,8990 4,6904 5,2915 4,4721 4,4721 4,2426 4 3,7417 5,4772 5,6569 5,0990 5,4772 5,6569 4 4 5,2915 4,4721 5,2915 4,2426 5,2915 5,2915 5,4772 4,4721 4,6904 5,0990 4,2426 5,4772 5,2915 5,2915 5,2915 2,8284 4,2426 4,4721 4,6904 4,2426 5,6569 5,4772 4,6904 5,4772 5,6569 4,4721 4,8990 5,4772 4 4,6904 4,6904 5,2915 4,8990 0 5,2915 6,1644 5,6569 4 4 5,0990 5,0990 5,1962 5,7446 5 6 6 4,8990 5,0990 5,6569 5,4772 5,6569 4,8990 5,0990 5,6569 5 Ph.D.6,4031 Program5,7446 5,6569 5,8310 5,8310 4,8990 5,0990 5,6569 4,6904 5,8310 5,8310 5,2915 5,0990 5,1962 6 6,1644 5,6569 5,6569 5,8310 5,7446 5,7446 5,7446 6,3246 5,2915 6 5,0990 4,2426 5,0990 5,4772 5,2915 5,4772 5,8310 5,8310 5,6569 5,2915 5,2915 5,0990 4,8990 4,8990 4,8990 4,8990 5,0990 5,6569 5,4772 6,4807 6 5,4772 5,2915 6 6,1644 6,3246 5,6569 5,2915 5,4772 5,4772 5,8310 4,8990 4,8990 3,7417 5,2915 5,6569 5,8310 6,3246 6 6 5,8310 5,6569 6,1644 6,3246 5,2915 4,8990 5,4772 5,4772 5,6569 5,6569 5,6569 5,4772 5,2915 0 5,4772 5,8310 5,4772 6 5,8310 5,8310 6,0828 6,2450 6,0828 6,4807 6,6332 5,2915 6 6 6,6332 6,1644 6,4807 6,3246 6,7823 6,4031 7 5,7446 6,3246 6,4807 6,4807 5,6569 6 6 5,6569 6,1644 6,3246 6,1644 5,8310 5,9161 6,6332 6,7823 6,1644 6,1644 6,3246 6,4031 5,9161 5,5678 pp. 108—113 7,4833 6,6332 6,6332 6,7823 4,8990 5,4772 6,3246 6,6332 6,9282 7,0711 6,4807 6,4807 6,3246 6,3246 6,7823 5,6569 5,4772 5,4772 5,4772 5,6569 5,8310 5,8310 4,8990 5,6569 7,0711 6,3246 6,9282 6,9282 7,0711 6,6332 6,6332 6,7823 6,4807 7,0711 5,6569 5,6569 5,0990 6,1644 5,8310 5,8310 5,4772 6,1644 7,2111 7,0711 6,3246 6,6332 6,7823 6,3246 6,7823 6,4807 6,4807 6,6332 6,1644 6,7823 6,4807 6,1644 5,4772 0 5,8310 5,6569 5,6569 5,6569 5,2915 6,8557 7,2801 6,7082 7,4833 7,3485 6,7823 6,7823 6,7823 4,4721 6,3246 5,6569 5,4772 6,3246 5,5678Employees7,1414 7,1414 6,6332 6,4807 6,4807 6 6,1644 6,6332 6 6,1644 5,4772 6,1644 6 6,2450 6,6332 6,7823 6,6332 6,3246 6,4807 6,2450 7,1414 7 6,3246 5,2915 5,6569 6 5,6569 5,8310 5,6569 5,2915 5,4772 5,6569 5,4772 5,2915 5,2915 5,6569 6 5,6569 5,4772 6 5,2915 5,6569 5,2915 6,0000 5,4772 5,0990 5,6569 4,8990 5,8310 6 6 5,2915 5,2915 5,6569 5,8310 5,8310 6,1644 6,1644 6 5,8310 5,0990 4,6904 5,4772 5,6569 6,1644 6 5,2915 6 6 4,8990 5,2915 5,2915 5,2915 5,0990 5,2915 5,6569 5,6569 5,6569 5,8310 5,8310 0 5,4772 5,2915 5,2915 5,6569 5,7446 6,0828 5,9161 6,1644 6,4807 5,0990 5,6569 5,2915 6 5,0990 5,6569 6 6,1644 5,7446 6,7082 6,0828 5,0990 5,6569 5,8310 4,8990 4,8990 5,2915 4,6904 5,0990 5,2915 5,8310 5,6569 5 5,8310 6,1644 5,4772 5,2915 5,4772 5,1962 6,0828 6,2450 pp. 114—115 6 5,6569 4,8990 4,6904 4,6904 4,8990 4 5,0990 5,2915 5,6569 4,6904 4,4721 4,4721 4,4721 4,6904 5,0990 5,0990 4,8990 4,8990 4,8990 3,1623 4,2426 4,6904 3,7417 5,8310 4,6904 5,6569 5,2915 5,8310 4,8990 5,0990 5,4772 4,6904 5,8310 5,0990 5,0990 5,2915 4,2426 3,7417 4,2426 4,6904 4,2426 6 5,8310 4,8990 5,6569 6 4,8990 5,2915 5,0990 4,6904 5,0990 5,0990 5,8310 5,2915 4 5,4772 5,6569 5,4772 0 3,7417 4,2426 4,2426 5,3852 6,0828 5,1962 6,4807 6,6332 5,4772 5,4772 5,4772 4,6904 5,6569 4,6904 4,4721 5,2915 5 Directory6,5574 6,0828 5,4772 5,4772 5,4772 4,4721 4,6904 5,4772 4,2426 5,6569 5,4772 4,2426 4,2426 5 5,6569 5,6569 5,4772 5,4772 5,6569 5,5678 6,0828 5,9161 6,4807 5,8310 5,2915 4,8990 4,8990 4,8990 4,4721 5,8310 5,8310 6,3246 5,4772 5,4772 5,2915 5,0990 5,2915 5,2915 5,4772 5,6569 5,2915 5,4772 4,4721 4,4721 5,0990 4,2426 6 5,2915 5,8310 6,1644 6 5,4772 5,6569 6,1644 5,2915 6,1644 5,8310 5,8310 5,8310 4,4721 4,2426 3,7417 4,8990 4,2426 6,3246 6,1644 5,6569 6,3246 6,1644 5,4772 6 6 5,0990 5,6569 5,6569 6,3246 6 4 6 5,6569 5,2915 3,7417 0 4 4,8990 5,7446 6,4031 5,5678 6,9282 6,6332 6 6 6,1644 4,2426 6 5,0990 4,2426 5,4772 5,1962 6,8557 6,7082 5,8310 6,1644 6,1644 5,2915 5,0990 6,1644 5,0990 6,3246 5,2915 4,4721 4,6904 5,3852 6 6,1644 5,4772 6,1644 6 5,5678 6,4031 6,2450 pp. 116—119 6,7823 5,8310 6 5,6569 5,2915 5,2915 5,0990 5,8310 6,1644 6,3246 5,8310 5,6569 5,4772 5,0990 5,6569 5,0990 5,0990 5,6569 4,8990 5,2915 4,6904 5,0990 5,0990 4,4721 6,1644 5,2915 6 6,1644 6,3246 5,6569 5,6569 6,1644 5,2915 6,4807 5,4772 5,4772 5,2915 5,0990 4,6904 4 5,2915 4,2426 6,6332 6,4807 5,6569 6 6,1644 5,2915 6 6 5,4772 5,6569 5,4772 6,1644 6 5,0990 5,8310 5,6569 5,2915 4,2426 4 0 4,8990 6,0828 6,4031 5,7446 6,6332 6,7823 5,8310 6 6,1644 5,0990 6,1644 5,2915 5,0990 6 5,3852Publications6,8557 6,5574 5,2915 5,6569 5,6569 5,2915 5,4772 5,6569 5,0990 6,3246 5,4772 4,6904 4,4721 5,1962 6 6,1644 5,4772 5,8310 6 5,3852 6,5574 6,4031 6,4807 6 5,4772 5,4772 4,8990 5,2915 4,6904 5,4772 5,8310 6 5,2915 5,2915 5,2915 4,8990 5,4772 5,4772 5,4772 5,6569 5,2915 5,2915 4,2426 5,4772 4 4,6904 6,1644 5,2915 6 5,8310 6,1644 5,6569 5,6569 5,6569 5,0990 6 5,6569 5,6569 5,6569 5,0990 4,8990 4,6904 3,4641 4,8990 6,1644 6 5,0990 6 6,1644 5,2915 5,8310 5,4772 5,6569 5,6569 5,4772 6,1644 5,8310 5,0990 5,8310 5,2915 5,6569 4,2426 4,8990 4,8990 0 5,9161 6,5574 5,9161 6,9282 6,9282 6 5,8310 6 4,6904 4,8990 4 3,7417 4 3,3166 6,2450 6,4031 5,8310 5,8310 5,8310 4,8990 5,2915 6 5,0990 5,0990 5,2915 4,6904 4,2426 5 6 6,1644 5,2915 5,4772 5,6569 5,1962 6,2450 5,9161 pp. 120—123 4,5826 4,7958 4,5826 5 5,3852 5,5678 4,1231 4,7958 5,1962 5,1962 4,7958 4,5826 4,3589 5 5 6,0828 5,5678 5,5678 5,7446 5,7446 4,7958 5,7446 5,9161 5,1962 4,5826 4,5826 4,5826 4,7958 5,3852 4,5826 5 4,7958 5,1962 4,5826 5,5678 5,5678 5,3852 5 5 5,3852 5,7446 5,5678 4,3589 4,3589 3,6056 5,3852 5 4,1231 5 5,1962 4,7958 5 5,1962 5,5678 4,5826 5,1962 6,0828 6,8557 5,7446 5,3852 5,7446 6,0828 5,9161 0 4 2,4495 5,7446 5,3852 4,3589 5,1962 5,3852 6,0828 5,9161 5,9161 5,7446 5,3852 5,6569Facts4,2426 & 4,4721Figures5,3852 5,7446 5,9161 5,1962 4,7958 5,7446 5 6,0828 5,5678 5,9161 6,0828 4,6904 5,5678 5,5678 5,3852 5,9161 5,7446 4,8990 5,0990 4,6904 5,1962 4,5826 4,7958 5,1962 6,0828 6,2450 5 5 5 4,5826 5 4,7958 5 5,7446 5,5678 6,7082 6,5574 6,0828 6,4031 6,4031 5,5678 6,2450 6,5574 5,9161 4,5826 5,1962 5,5678 5,3852 5,5678 5,1962 5,1962 5 5,5678 4,3589 5,9161 5,9161 6,0828 5,7446 5,7446 6,0828 6,4031 6,2450 4,7958 4,7958 4,3589 6,0828 5,7446 4,7958 4,5826 5,3852 5,7446 5,1962 5,1962 5,1962 5 5,7446 6,2450 7,2801 6,0828 6,0828 6,4031 6,4031 6,5574 4 0 3,4641 5 4,5826 3,8730 5,3852 5,1962 6,7082 6,0828 6,5574 6,4031 6,4031 6,3246 4,6904 4,6904 5,3852 5,9161 6,0828 5,7446 5,3852 5,1962 5,5678 6,0828 6,0828 6,5574 6,7082 5,6569 5,9161 6,2450 5,9161 5,3852 5,1962 5,4772 4,2426 5,2915 pp. 124—127 5 4,5826 4,5826 4,7958 5,3852 5,5678 3,8730 4,7958 5,1962 5,1962 4,7958 4,5826 4,1231 4,7958 5,1962 6,0828 5,9161 5,3852 5,7446 5,7446 4,5826 5,3852 5,9161 5 4,5826 4,5826 5 5,1962 5,3852 5 5 5,1962 5 5,0000 5,1962 5,1962 5,3852 4,7958 4,7958 5,1962 5,5678 5,5678 4,7958 4,7958 3,6056 5,5678 5,1962 4,5826 5 5,5678 4,5826 5 5 5,7446 4,5826 5 6,0828 6,7082 5,9161 5,1962 5,5678 5,7446 5,9161 2,4495 3,4641 0 5,7446 5,3852 4,7958 5,1962 5,7446 5,9161 5,7446 5,9161 5,5678 5,5678 5,6569Testimonials4,4721 4,6904 5,1962 5,3852 5,5678 5,1962 4,7958 5,3852 5,0000 6,0828 5,5678 5,7446 5,9161 5,0990 5,3852 5,7446 5,3852 5,5678 5,3852 4,8990 4,8990 4,8990 5,2915 5,2915 5,8310 6,1644 6,9282 7,0711 6 5,6569 5,4772 4,6904 5,6569 5,6569 5,6569 5,8310 5,8310 6,9282 6,4807 6,4807 6,6332 6,9282 6,1644 6,3246 7,0711 6,4807 5,8310 5,0990 4,8990 4,8990 5,2915 5,2915 5,4772 5,0990 6 5,2915 6,4807 6,4807 6 6,1644 6,1644 6,3246 6,6332 6,6332 6 5,8310 5,6569 5,0990 5,0990 4,6904 5,2915 5,4772 5,0990 4,8990 5,0990 5,0990 5,0990 6 6,4807 7,4833 6,1644 6,4807 6,9282 6,6332 6,9282 5,7446 5 5,7446 0 3,4641 3,7417 5,2915 5,0990 7,2111 6 6,7823 6,9282 6,6332 6,7082 6,0828 5,7446 4,8990 5,2915 5,4772 5,2915 5,2915 4,4721 5,6569 6 6,6332 6,9282 6,7823 5,5678 5,6569 5,6569 6,1644 5,4772 5,6569 5,7446 5,1962 5,9161 pp. 128—129 5,2915 5,0990 5,6569 5,8310 6,6332 6,7823 5,6569 5,6569 5,6569 4,8990 5,8310 5,8310 5,6569 6 5,8310 7,0711 6,6332 6,6332 6,7823 6,9282 6,1644 6,4807 7,0711 6,4807 5,6569 5,6569 4,6904 5,2915 5,4772 5,6569 6 5,0990 6,1644 4,8990 6,4807 6,4807 6,1644 6 6 6,4807 6,4807 6,4807 5,6569 5,4772 5,6569 4,6904 4,4721 4,8990 5,2915 5,4772 5,6569 5,4772 5,8310 5,4772 5,0990 6 6,6332 7,3485 6,4807 6,6332 6,6332 6,7823 6,9282 5,3852 4,5826 5,3852 3,4641 0 4 5,6569 5,4772 6,7823 6,3246 6,7823 6,4807 6,3246 6,5574Acknowledgements5,7446 5,7446 4,6904 5,0990 5,0990 6 5,6569 4,6904 6 6,3246 6,4807 6,7823 6,9282 5,7446 4,8990 5,0990 6 5,8310 5,6569 5,5678 4,7958 5,5678 5,0990 4 4,8990 4,8990 5,8310 6 4,6904 4,2426 4,2426 4,2426 4,6904 4,4721 4,2426 4,6904 4,4721 5,8310 5,2915 5,6569 5,4772 5,8310 4,8990 5,6569 6 5,2915 4,4721 4 4,4721 4,6904 5,2915 4 4,4721 3,7417 4,8990 4 5,6569 5,6569 5,0990 4,8990 4,8990 5,0990 5,6569 5,4772 4,8990 4,6904 4,4721 4,8990 4,8990 2,8284 3,7417 4,2426 4,6904 4,4721 4,6904 4,2426 4 4,8990 5,2915 6,7823 5,0990 5,4772 6 5,8310 6 4,3589 3,8730 4,7958 3,7417 4 0 4,6904 4 6,3246 5,0990 5,8310 6 5,8310 5,7446 5,3852 4,5826 4,6904 5,2915 5,4772 4,6904 4,6904 4,4721 4,4721 5,0990 5,4772 6 5,8310 4,3589 5,4772 5,4772 5,2915 4,6904 4,8990 5 4,3589 5 pp. 130—131 5,6569 4,8990 4 5,6569 6 6,1644 5,0990 4,6904 4,8990 4,6904 3,7417 3,7417 4,4721 4,8990 5,6569 6 6 5,6569 5,8310 6,1644 5,2915 5,6569 6 5,6569 5,0990 3,7417 4,6904 4,4721 3,1623 3,7417 3,7417 4,8990 4,6904 4,8990 5,8310 5,8310 5,6569 5,0990 5,0990 5,4772 5,8310 5,6569 5,6569 5,4772 4,4721 4,8990 5,0990 4,2426 5,2915 5,4772 4,4721 3,7417 3,7417 4,6904 5,4772 5,0990 6 6,7823 5,6569 5,4772 6 6 5,8310 5,1962 5,3852 5,1962 5,2915 5,6569 4,6904 0 4,6904 6,3246 5,6569 5,6569 6 6 5,5678How6,2450 to 5,7446Reach5,2915 CeMM5,0990 5,0990 4,2426 4,4721 5,2915 4,2426 5,4772 5,4772 6 5,8310 4,5826 5,2915 5,4772 4,6904 5,4772 5,6569 5,1962 5,3852 5,5678 5,4772 4,6904 4,8990 5,6569 6,1644 6,3246 5,6569 4,8990 4,4721 4,6904 4,6904 4,4721 5,2915 5,4772 5,2915 6,1644 5,6569 6,1644 5,8310 6,1644 5,0990 6,3246 6 5,4772 5,0990 4,6904 5,2915 5,0990 5,2915 4,2426 4,6904 4,2426 5,2915 3,7417 6,4807 6,4807 6 5,8310 5,2915 5,4772 5,8310 5,8310 5,2915 5,0990 5,0990 5,4772 5,4772 4,4721 5,0990 3,7417 5,4772 4,6904 4,6904 3,1623 4,4721 5,6569 6 6,7823 5,2915 5,4772 6,1644 6,1644 6 5,3852 5,1962 5,7446 5,0990 5,4772 4,0000 4,6904 0 6,3246 4,6904 5,8310 6,1644 6 5,7446 6,4031 5,1962 5,4772 5,0990 5,2915 4,2426 4,2426 4,4721 4,0000 4,2426 5,4772 6,1644 6 4,3589 5,2915 5,2915 5,2915 4,2426 4,4721 5 5,3852 5,3852 p. 132 6,9282 6,3246 6 5,6569 5,6569 5,8310 5,0990 6,3246 6,6332 6,7823 6,1644 6,1644 5,8310 5,4772 6 6,1644 6,1644 6,3246 6 6,1644 4,8990 5,4772 3,7417 4,6904 6,3246 6 6,3246 6,6332 6,4807 6,3246 6,3246 6,4807 5,6569 6,4807 6,3246 6,3246 6,3246 5,2915 5,0990 4,8990 4,4721 5,2915 6,7823 6,6332 6,1644 6,7823 6,6332 6,1644 6,6332 6,3246 6,1644 6,4807 6,3246 6,7823 6,4807 5,4772 6,6332 4,4721 6 4,6904 4,2426 5,0990 4,6904 6,0828 6,7082 5,9161 7,2111 6,7823 6,3246 6,3246 6,3246 0 5,6569 4,6904 3,1623 4,8990 4,5826Imprint6,7082 7,1414 6,4807 6,3246 6,3246 5,6569 5,4772 6,4807 5,6569 5,8310 4,6904 4,6904 4,8990 5,9161 6,1644 6,3246 6 6,1644 6 5,7446 6,7082 6,5574 6,4807 5,2915 5,8310 5,6569 6,1644 6,3246 5,4772 5,4772 5,2915 5,8310 5,6569 5,4772 5,4772 5,2915 5,6569 6,1644 6 6,3246 5,8310 6,1644 5,0990 6,3246 5,4772 5,4772 5,6569 5,2915 6,1644 6,3246 6,1644 5,6569 5,6569 5,4772 5,4772 5,6569 6,6332 6,6332 6,4807 5,8310 5,0990 5,0990 4,2426 5,8310 6,1644 6 5,6569 6,3246 6,3246 5,4772 5,4772 5,2915 5,4772 5,6569 5,6569 5,4772 5,2915 5,6569 6,1644 6,3246 5,0990 5,6569 6 6,1644 4,8990 5,9161 6,0828 5,7446 6 6,3246 5,0990 5,6569 4,6904 5,6569 0 4,8990 4,8990 4,8990 4,5826 6,4031 6,0828 5,6569 5,8310 6 5,0990 5,0990 5,4772 4,8990 2,8284 5,6569 5,6569 5,4772 5,1962 6 6,3246 5,6569 4,4721 4,6904 5,3852 6,0828 6,0828 6,6332 6 5,4772 5,6569 5,6569 5,6569 4,8990 5,4772 5,8310 6,1644 5,2915 5,2915 5,4772 5,0990 5,6569 5,6569 5,6569 6 5,4772 5,6569 4,4721 5,4772 4 4,8990 6,1644 5,0990 6 6 6,1644 5,2915 5,4772 6 5,2915 6,3246 6,1644 6,1644 6,1644 4,8990 4,6904 4,6904 3,7417 4,4721 6,4807 6,3246 5,6569 6,3246 6,4807 5,4772 6,1644 6 5,6569 5,6569 5,6569 6,3246 6,3246 4,8990 6,4807 5,6569 5,6569 4,6904 5,0990 5,2915 4 5,9161 6,5574 5,9161 6,7823 6,7823 5,8310 5,6569 5,8310 4,6904 4,8990 0 4,2426 4,6904 3 6,7082 6,5574 5,8310 6 6 5,0990 5,2915 6 4,8990 5,2915 5,2915 5,0990 4,8990 5 6,1644 6,3246 5,0990 5,4772 5,6569 5,3852 6,5574 6,4031 6,6332 6 5,6569 5,2915 5,0990 5,2915 4,6904 6 6,3246 6,4807 5,8310 5,8310 5,4772 5,0990 5,6569 5,6569 5,6569 6 5,4772 5,6569 4,6904 5,0990 4,6904 5,0990 6 5,6569 6 6,3246 6,1644 6 6 6,1644 5,2915 6,1644 6 6 6 4,8990 4,4721 4,8990 3,1623 4,6904 6,4807 6,3246 5,8310 6,4807 6,3246 5,8310 6,3246 6,1644 5,8310 6,1644 6 6,4807 6,1644 5,0990 6,3246 5,4772 6 4,4721 4,2426 5,0990 3,7417 5,7446 6,4031 5,5678 6,9282 6,4807 6 6 6,1644 3,1623 4,8990 4,2426 0 4 3,6056 6,2450 6,8557 6 6,1644 6,1644 5,4772 5,2915 6,3246 5,4772 5,4772 5,4772 3,7417 4 5,3852 6 6,1644 5,4772 5,8310 5,6569 5,1962 6,4031 6,2450 6,4807 6,1644 5,8310 5,4772 5,6569 5,8310 4,4721 6,1644 6,4807 6,4807 6 6 5,2915 4,6904 5,4772 6 5,8310 6,4807 6 5,6569 4,4721 6,1644 4,8990 4,8990 6,4807 6 6 6,1644 6,4807 6 6,1644 6 4,8990 5,8310 6,4807 6,4807 6,3246 5,0990 5,2915 4,8990 3,7417 5,4772 6,3246 6,1644 5,8310 6,4807 6,1644 5,6569 6,1644 5,6569 6,1644 6,3246 6,3246 6,6332 5,8310 5,6569 6,7823 6,3246 6,1644 5,2915 5,4772 6 4 5,3852 6,4031 5,5678 6,6332 6,3246 5,8310 6 6 4,8990 4,8990 4,6904 4 0 4,1231 5,5678 6,2450 6,1644 6,3246 6,4807 5,8310 5,4772 6,4807 5,8310 5,6569 5,8310 5,0990 5,2915 5,3852 6,1644 6,1644 4,8990 6 5,8310 5,1962 6,0828 5,9161 6,5574 5,9161 5,5678 5,5678 5,5678 5,7446 4,7958 5,3852 5,9161 6,0828 5,3852 5,3852 5,3852 4,7958 5,5678 5,7446 5,7446 6,0828 5,5678 5,7446 4,3589 5,5678 4,1231 4,7958 6,0828 5,1962 5,9161 5,9161 6,0828 5,5678 5,5678 5,7446 5 6,0828 6,0828 6,0828 6,0828 4,7958 4,5826 4,5826 3 4,5826 6,2450 6,0828 5,3852 6,0828 6,2450 5,3852 6,0828 5,7446 5,7446 5,7446 5,5678 6,2450 6,0828 5 6,4031 5,5678 5,7446 5 5,1962 5,3852 3,3166 5,6569 6,3246 5,6569 6,7082 6,5574 5,7446 5,5678 5,7446 4,5826 4,5826 3 3,6056 4,1231 0 6,1644 6,3246 5,7446 5,7446 5,7446 5 5,1962 5,9161 5 5 5,3852 5 4,7958 4,2426 5,9161 6,0828 5,1962 5,3852 5,5678 4,6904 6,1644 6 5,7446 5,7446 5,5678 6,2450 6,5574 6,7082 5,5678 5,9161 6,2450 6,2450 5,7446 5,7446 5,1962 5,7446 6,2450 6,8557 6,7082 6,5574 6,8557 6,5574 6,0828 6,7082 6,5574 6,4031 5,7446 5,7446 5,7446 5,9161 6,2450 5,7446 5,9161 5,7446 5,9161 5,5678 6,4031 6,4031 6,2450 5,9161 6,2450 6,5574 6,0828 6,7082 5,3852 5,3852 4,5826 6,0828 5,7446 5 5,5678 5,9161 6,2450 6,0828 5,9161 6,2450 5,7446 6,4031 7 7,1414 6,7082 6,5574 6,8557 6,8557 6,2450 4,2426 4,6904 4,4721 6,0828 5,7446 5,3852 6,2450 6,4031 6,7082 6,4031 6,7082 6,2450 5,5678 6,1644 0 4,8990 5,5678 6,0828 6,2450 5,9161 5,5678 6,2450 5,9161 6,0828 5,5678 6,7082 6,8557 5,4772 6,2450 6,2450 5,9161 5,5678 5,3852 5,4772 5,2915 5,4772 4,5826 4,3589 5,3852 5,1962 6,4031 6,5574 5,3852 4,5826 4,7958 5 5,1962 5 4,5826 5,3852 4,7958 6,4031 6,2450 5,9161 6,4031 6,0828 5,5678 6,0828 6,4031 5,9161 4,3589 5 5,3852 5,1962 6,0828 5 5,1962 4,3589 5,5678 4,5826 6,0828 6,0828 5,9161 5,3852 5,7446 6,0828 6,4031 6,2450 4,5826 4,1231 4,3589 5,3852 5,3852 4,5826 4,5826 4,5826 5,7446 5,3852 5,1962 4,7958 4,3589 5,7446 5,7446 7,1414 6,0828 6,0828 6,7082 6,5574 6,4031 4,4721 4,6904 4,6904 5,7446 5,7446 4,5826 5,7446 5,1962 7,1414 6,0828 6,5574 6,8557 6,2450 6,3246 4,8990 0 5,7446 5,7446 5,9161 5,3852 5,3852 5,1962 5,1962 5,5678 6,0828 6,7082 6,5574 4,8990 6,0828 6,0828 5,7446 5,5678 5,7446 5,4772 4,8990 4,6904 5,6569 5,0990 5,4772 6 5,6569 5,8310 5,2915 5,2915 5,6569 4,8990 5,2915 5,0990 4,8990 5,2915 6 5,6569 5,4772 6 5,2915 5,6569 4,8990 6 6 5,2915 5,6569 4,6904 4,4721 4,8990 5,0990 5,0990 5,0990 5,6569 5,4772 5,8310 5,8310 5,8310 5,6569 5,4772 4,6904 4,8990 5,4772 5,2915 6,3246 6,1644 5,0990 4,4721 4,4721 4,2426 5,0990 5,4772 4,6904 4,4721 5,0990 5,8310 5,6569 5,6569 6,3246 6,6332 5,0990 5,4772 5,8310 5,2915 5,8310 5,3852 5,3852 5,1962 4,8990 4,6904 4,6904 5,2915 5,4772 6,4807 5,6569 5,8310 6 6,1644 5,7446 5,5678 5,7446 0 3,1623 3,4641 4,4721 4,4721 3,4641 4,2426 5,4772 5,2915 5,6569 5,4772 4,3589 4 4,4721 5,0990 5,0990 5,2915 4,7958 5,5678 6,0828 5,6569 5,0990 5,2915 6,1644 6 6,1644 5,4772 5,0990 5,4772 4,8990 5,0990 5,0990 5,0990 5,2915 6,1644 6 5,8310 6,1644 5,6569 6 4,8990 6,1644 5,8310 5,2915 5,6569 4,6904 4,4721 4,8990 4,8990 5,0990 5,0990 5,4772 5,4772 5,6569 5,8310 5,8310 5,8310 5,6569 5,0990 5,2915 5,6569 5,4772 6 6 4,8990 4 3,7417 4,6904 5,6569 5,0990 4,8990 4,4721 4,8990 5,6569 5,6569 5,8310 6,4807 6,4807 5,6569 5,4772 6,1644 5,6569 5,8310 5,7446 5,9161 5,3852 5,2915 5,0990 5,2915 5,0990 5,0990 6,3246 5,8310 6 6,1644 6,3246 5,7446 6,0828 5,7446 3,1623 0 2 4 4 3,1623 4 5,0990 5,0990 5,6569 5,4772 4,3589 3,1623 3,4641 5,0990 4,8990 5,0990 4,7958 5,7446 5,9161 5,6569 5,2915 5,2915 6,1644 6 6,1644 5,6569 5,0990 5,4772 5,0990 5,0990 5,0990 5,0990 5,4772 6,1644 6 6 6,1644 5,8310 6,1644 5,0990 6,1644 5,8310 5,4772 5,6569 4,6904 4,4721 4,8990 4,8990 5,0990 5,0990 5,4772 5,6569 5,8310 5,8310 5,8310 5,8310 5,6569 5,0990 5,4772 5,8310 5,4772 6 6 5,0990 3,7417 4,2426 4,8990 5,8310 5,2915 4,8990 4,6904 4,8990 5,6569 5,8310 5,8310 6,4807 6,4807 5,8310 5,4772 6,1644 5,6569 5,8310 5,9161 6,0828 5,5678 5,4772 5,0990 5,4772 5,0990 5,2915 6,3246 6 6 6,1644 6,4807 5,7446 6,2450 5,9161 3,4641 2 0 4 4,2426 3,4641 4 5,2915 5,0990 5,6569 5,4772 4,3589 3,1623 3,7417 5,0990 5,0990 5,2915 4,7958 5,9161 5,9161 5,6569 4,6904 4,2426 5,4772 5,0990 5,4772 4,8990 4,4721 4,6904 5,0990 4 4 4,2426 4,6904 5,4772 5,2915 5,2915 5,4772 5,0990 5,4772 4,2426 5,2915 5,0990 4,6904 4,8990 3,1623 4,6904 4,8990 4,6904 4 3,7417 4,6904 4,8990 5,0990 5,6569 5,6569 5,2915 4,8990 4,2426 4,6904 5,0990 4,8990 5,4772 5,2915 4,2426 4,8990 5,0990 4 5,0990 4,4721 4,4721 4,2426 3,4641 4,8990 5,2915 4,8990 5,6569 6 4,8990 4,4721 5,2915 5,2915 4,8990 5,1962 5,7446 5,1962 5,2915 6 4,6904 4,2426 4,2426 5,6569 5,0990 5,0990 5,4772 5,8310 5 5,9161 5,3852 4,4721 4 4 0 2 4,2426 2,4495 4,2426 4 5,0990 4,6904 3,3166 4,4721 4,6904 4,2426 4,4721 4,6904 4,3589 5,3852 5,1962 5,4772 4,2426 4,0000 5,2915 5,0990 5,2915 4,4721 4,6904 4,8990 5,0990 4,2426 4,2426 4,4721 4,6904 5,6569 5,4772 5,2915 5,6569 5,0990 5,4772 4,2426 5,4772 5,2915 4,6904 4,6904 3,4641 4,4721 5,0990 4,4721 4,2426 4 4,8990 4,8990 4,6904 5,8310 5,8310 5,6569 5,0990 4,4721 4,6904 5,0990 5,0990 5,2915 5,0990 4,2426 5,0990 4,6904 4 5,0990 4,4721 4,6904 4,2426 3,7417 5,0990 5,2915 5,0990 6 6,1644 4,8990 4,6904 5,0990 5,4772 5,2915 4,7958 5,3852 4,7958 5,2915 5,6569 4,6904 4,4721 4,2426 5,4772 5,0990 5,2915 5,2915 5,4772 5,1962 5,5678 5,3852 4,4721 4 4,2426 2 0 4,2426 2,8284 4,2426 4 4,8990 5,0990 3,6056 4 4,4721 4 4,4721 4,2426 4,1231 5 5,1962 5,0990 4,4721 5,4772 5,6569 6 6,1644 5,4772 4,8990 4,8990 3,7417 5,2915 5,0990 5,0990 5,4772 5,6569 6 5,8310 6,1644 5,6569 6 4,8990 6,1644 5,8310 5,2915 5,0990 4,6904 4,6904 4,6904 4,8990 5,0990 5,0990 4,8990 5,6569 5,0990 6 6 5,8310 5,6569 5,0990 5,2915 5,8310 5,6569 5,8310 5,6569 5,0990 4,6904 4,6904 4,6904 5,0990 4,4721 4,6904 4,2426 5,0990 5,0990 5,0990 5,6569 6 6,6332 5,2915 5,4772 6,1644 5,6569 6 5,7446 5,1962 5,3852 4,4721 4,6904 4,4721 5,2915 4,4721 6,4807 5,4772 6 6,3246 6,4807 5,9161 6,2450 5,1962 3,4641 3,1623 3,4641 4,2426 4,2426 0 4 4,6904 5,0990 6 5,8310 4,5826 4 4,4721 5,2915 4 4,2426 5 5,1962 5,7446 5,4772 4,4721 4,2426 5,2915 5,0990 5,2915 4,6904 4,2426 4,2426 4,8990 4,0000 3,4641 4 4,6904 5,2915 5,0990 5,0990 5,0990 4,8990 5,2915 4 5,2915 4,8990 4,4721 4,6904 3,1623 4,4721 4,6904 4,6904 3,7417 3,7417 4,6904 4,8990 5,0990 5,4772 5,4772 5,2915 4,6904 4 4,4721 5,0990 4,6904 5,4772 5,2915 4,2426 4,8990 5,0990 3,7417 4,8990 4,4721 4,2426 4 4 4,6904 5,2915 4,6904 5,6569 6 4,6904 4,2426 5,0990 5,0990 5,0990 5 5,5678 5 5,6569 6 4,4721 4,2426 4 5,6569 4,8990 4,8990 5,4772 5,8310 5 5,9161 5,1962 4,2426 4 4 2,4495 2,8284 4 0 4 4 5,0990 4,8990 3,3166 4,4721 4,6904 4,2426 4 4,2426 4,1231 5,3852 5,3852 6,1644 4,8990 5,4772 5,8310 6,3246 6,4807 5,8310 5,0990 4,8990 5,4772 5,2915 5,0990 5,4772 5,6569 5,8310 6,3246 6,1644 6,3246 6 6,3246 5,2915 6,4807 5,2915 5,6569 5,2915 4,8990 5,8310 6 5,8310 5,2915 5,2915 5,0990 5,8310 5,2915 6,6332 6,6332 6,4807 6 5,4772 5,6569 4,8990 6 5,8310 5,6569 5,2915 6 6 5,0990 5,2915 4,6904 5,6569 5,2915 5,2915 5,0990 5,4772 5,8310 6,1644 6,1644 5,0990 5,6569 6,3246 6,3246 5,0990 6,0828 6,0828 6,0828 6 6,3246 5,0990 5,4772 4,2426 5,8310 2,8284 5,2915 5,4772 5,6569 5 6,0828 5,5678 5,4772 5,0990 5,2915 4,2426 4,2426 4,6904 4 0 4,8990 5,8310 5,6569 4,7958 5,4772 5,8310 5,4772 3,7417 4 5,1962 5,7446 5,9161 6 5,0990 5,0990 5,8310 5,4772 5,8310 5,2915 5,2915 5,6569 5,8310 5,2915 5,0990 5,0990 5,6569 6,1644 6 6 6,3246 5,8310 6,1644 5,0990 6,3246 4,2426 4,8990 5,2915 4,6904 5,0990 5,6569 5,4772 5,0990 5,0990 5,6569 5,8310 5,6569 6,3246 6,3246 6 5,6569 5,0990 4,8990 5,4772 5,6569 6 5,8310 5,2915 5,8310 5,6569 4,8990 5,8310 5,4772 5,4772 5,2915 5,2915 6 6,1644 5,8310 6,3246 5,4772 5,2915 5,4772 5,2915 5,4772 5,2915 5,5678 6,0828 5,5678 6,6332 6,4807 5,4772 5,4772 5,4772 4,6904 5,6569 5,2915 5,4772 5,8310 5,3852 5,5678 6,0828 5,2915 5,0990 5,0990 4 4 5,0990 4 4,8990 0 5,6569 5,6569 4,5826 5,0990 5,2915 4,8990 4,4721 4,2426 5 5,9161 5,7446 6,4807 5,8310 5,6569 5,2915 5,0990 5,0990 4,6904 5,8310 6,1644 6,4807 5,8310 5,6569 5,4772 4,8990 5,6569 5,2915 5,2915 6 5,0990 5,4772 4,6904 5,2915 5,4772 5,0990 6 5,4772 5,8310 6,1644 6 5,8310 5,8310 6,1644 5,0990 6,1644 5,8310 5,8310 5,8310 5,0990 4,4721 4,6904 4,4721 4,4721 6,3246 6,3246 5,8310 6 6 5,6569 6,3246 6,1644 5,6569 6 5,8310 6,4807 6,1644 5,2915 6,1644 6,1644 5,8310 4,2426 4,4721 4,6904 4,6904 5,9161 6,5574 5,7446 6,9282 6,7823 6 6 6,1644 4,6904 5,6569 5,0990 3,7417 5,0990 5 6,7082 6,7082 5,6569 5,6569 5,6569 5,0990 4,8990 6 5,0990 5,8310 5,6569 0 2 5 5,6569 5,6569 5,0990 6,3246 6,1644 5 6,4031 6,2450 6,7823 6 5,8310 5,4772 5,0990 5,2915 4,8990 5,6569 6 6,3246 5,6569 5,6569 5,2915 4,6904 5,4772 5,0990 5,0990 5,8310 4,8990 5,2915 4,4721 5,0990 5,2915 4,8990 6,1644 5,2915 6 6,1644 6,1644 5,6569 5,6569 6 4,8990 6,3246 5,6569 5,6569 5,4772 4,8990 4,4721 4,4721 4,2426 4,2426 6,4807 6,4807 5,6569 6 6,1644 5,4772 6,1644 6 5,4772 5,8310 5,6569 6,3246 6 5,0990 5,8310 6 5,6569 4,2426 4,6904 4,4721 4,2426 6,0828 6,7082 5,9161 6,7823 6,9282 5,8310 5,8310 6 4,8990 5,4772 4,8990 4 5,2915 4,7958 6,8557 6,5574 5,4772 5,4772 5,4772 4,6904 5,0990 5,8310 4,8990 5,6569 5,6569 2 0 4,7958 5,8310 6 5,2915 6,1644 6,3246 5,1962 6,5574 6,2450 5,3852 4,7958 4,5826 5,5678 5,1962 5,3852 5 4,3589 5 5,1962 4,3589 4,3589 4,3589 4,7958 5,1962 5,1962 4,7958 5,7446 5 5,3852 4,5826 5,7446 5,3852 5 5 3,8730 4,3589 4,5826 5,0000 3,8730 4,3589 4,3589 5 4,7958 5,7446 5,7446 5,1962 5 4,1231 4,5826 5 4,7958 5 4,7958 4,3589 4,5826 4,7958 3,6056 5,1962 4,3589 4,7958 4,5826 4,3589 4,7958 5 5,1962 5,9161 6,2450 5 5 5,3852 5,1962 5 4,6904 5,6569 5,0990 5,5678 5,7446 4,3589 4,5826 4,3589 5,9161 5,1962 5 5,3852 5,3852 4,2426 5,4772 4,8990 4,3589 4,3589 4,3589 3,3166 3,6056 4,5826 3,3166 4,7958 4,5826 5 4,7958 0 4,7958 4,5826 3,8730 5 5,1962 3,1623 5,2915 4,8990 5,4772 4,8990 5,0990 6 5,8310 6 5,2915 5,2915 5,6569 5,0990 5,2915 5,2915 5,2915 5,4772 6,3246 6,1644 6 6,3246 5,8310 6,1644 5,0990 6,3246 6 5,4772 5,4772 4,8990 4,2426 5,0990 4,6904 5,2915 5,2915 5,6569 5,6569 5,4772 6,1644 6,1644 6,1644 5,8310 5,2915 5,4772 5,8310 5,6569 5,8310 5,8310 5,0990 4 3,7417 4,8990 5,8310 5,2915 5,0990 4,6904 5,0990 5,8310 5,8310 6 6,6332 6,6332 5,8310 5,6569 6 6 6 5,5678 5,9161 5,3852 5,6569 4,8990 5,4772 5,2915 5,2915 6,1644 6 6,1644 6,0000 6,1644 5,9161 6,2450 6,0828 4 3,1623 3,1623 4,4721 4 4 4,4721 5,4772 5,0990 5,6569 5,8310 4,7958 0 2,4495 4,6904 5,0990 4,8990 4,5826 5,3852 5,5678 5,0990 5,2915 5,2915 6,1644 6 6,1644 5,6569 5,4772 5,8310 5,4772 5,4772 5,2915 5,4772 5,8310 6,1644 6,3246 6 6,4807 6,1644 6,4807 5,4772 6,4807 6,1644 5,8310 5,6569 5,0990 4 4,6904 4,8990 5,0990 5,4772 5,4772 6 5,4772 6,3246 6,3246 6 6 5,2915 5,8310 6,1644 5,8310 5,6569 5,6569 5,4772 3,7417 3,4641 4,8990 6,1644 5,2915 5,2915 5,0990 5,2915 5,6569 5,8310 6,1644 6,7823 6,7823 6,1644 5,6569 6,1644 6,1644 6,1644 5,5678 6,2450 5,7446 5,6569 5,0990 5,4772 5,4772 5,2915 6,3246 6,3246 6,3246 6,1644 6,1644 6,0828 6,2450 6,0828 4,4721 3,4641 3,7417 4,6904 4,4721 4,4721 4,6904 5,8310 5,2915 5,6569 6 4,5826 2,4495 0 4,8990 5,4772 5,2915 4,3589 5,7446 5,3852 5,8310 4,8990 4,6904 5,6569 5,2915 5,2915 5,0990 4,8990 5,4772 5,6569 4,8990 4,8990 4,4721 4,8990 6 5,0990 5,4772 6,1644 5,2915 5,2915 5,0990 6,1644 5,8310 5,4772 5,0990 4,4721 4,8990 5,4772 5,0990 4,8990 4,6904 5,2915 5,0990 5,2915 6,1644 6,1644 6 5,0990 4,6904 5,0990 5,4772 5,0990 5,4772 5,2915 4,8990 5,4772 5,2915 4,6904 5,4772 5,0990 5,2915 5,0990 4,8990 5,6569 5,8310 5,6569 6,1644 6,6332 5,4772 5,4772 5,4772 5,4772 5,2915 5,3852 5,9161 5,3852 6,1644 6 5,2915 4,6904 5,2915 6 5,6569 5,0990 5,4772 4,8990 5,1962 5,9161 5,7446 5,0990 5,0990 5,0990 4,2426 4 5,2915 4,2426 5,4772 4,8990 5,0990 5,2915 3,8730 4,6904 4,8990 0 5,2915 5,0990 4,1231 5,1962 5,3852 6,1644 4,6904 5,4772 5,8310 6,1644 6,3246 5,6569 5,0990 4,6904 5,0990 5,2915 4,8990 5,2915 5,6569 5,8310 6,1644 6 6 5,8310 6,1644 5,0990 6,1644 5,4772 5,4772 5,2915 4,6904 5,6569 5,8310 5,8310 5,0990 5,0990 5,0990 5,8310 5,2915 6,1644 6,1644 6 5,8310 5,2915 5,4772 5,2915 5,8310 6 5,8310 5,2915 5,8310 5,8310 4,8990 5,2915 4,6904 5,4772 5,0990 5,0990 4,8990 5,2915 5,6569 6,1644 6,3246 5,2915 5,4772 6,1644 5,8310 5,4772 5,9161 5,3852 5,5678 5,4772 5,8310 4,6904 5,4772 4,2426 6,1644 4,4721 5,4772 5,8310 6 5,3852 5,5678 5,5678 5,0990 4,8990 5,0990 4,4721 4,4721 4 4 3,7417 4,4721 6,3246 6,1644 5 5,0990 5,4772 5,2915 0 1,4142 5 5,3852 5,9161 6 4,4721 5,2915 5,6569 6 6,1644 5,4772 5,2915 4,8990 5,2915 5,4772 5,0990 5,4772 5,8310 6 6,3246 6,1644 6,1644 6 6,3246 5,2915 6,3246 5,6569 5,6569 5,0990 4,8990 5,4772 6 5,6569 5,2915 5,2915 5,2915 6 5,0990 6,3246 6,3246 6,1644 6 5,4772 5,6569 5,4772 6 5,8310 5,6569 5,4772 6 5,6569 5,0990 5,4772 4,8990 5,6569 5,2915 5,2915 5,0990 5,4772 5,8310 6,3246 6,4807 5,4772 5,6569 6 6 5,6569 5,7446 5,1962 5,3852 5,6569 5,6569 4,8990 5,6569 4,4721 6 4,6904 5,6569 5,6569 5,8310 5,5678 5,3852 5,7446 5,2915 5,0990 5,2915 4,6904 4,2426 4,2426 4,2426 4 4,2426 6,1644 6,3246 5,1962 4,8990 5,2915 5,0990 1,4142 0 4,7958 5,1962 5,7446 5,5678 4,7958 4,7958 5,7446 5,3852 5,5678 5,1962 5,1962 5,5678 5,7446 5 5 5 5,3852 5,7446 5,7446 5,3852 6,0828 5,5678 5,9161 5,1962 6,0828 5,5678 5,5678 5,1962 4,5826 4,5826 5,1962 5,1962 4,5826 5 5 5,5678 5 5,9161 5,9161 5,3852 5,5678 4,7958 5,1962 5,1962 5,3852 5,3852 5,1962 5 5 4,7958 4,3589 5,7446 5 5,3852 5,1962 4,7958 5,1962 5,3852 5,7446 6,4031 6,2450 5,1962 5,5678 5,5678 5,3852 5,1962 4,8990 5,4772 4,8990 5,7446 5,5678 5 5,1962 5 5,7446 5,3852 5,3852 5,1962 5,1962 4,6904 5,4772 5,4772 4,7958 4,7958 4,7958 4,3589 4,1231 5 4,1231 5,1962 5 5 5,1962 3,1623 4,5826 4,3589 4,1231 5 4,7958 0 5,2915 4,8990 5,5678 4,3589 4,7958 5,1962 6,0828 6,2450 5 4,7958 4,7958 4,7958 5 5 4,7958 5,3852 5,5678 6,5574 6,5574 6,0828 6,4031 6,2450 5,5678 6,2450 6,4031 5,9161 5 5 5,3852 5,5678 5,5678 5,3852 5 4,5826 5,5678 4,3589 6,0828 6,0828 6,2450 5,5678 5,7446 6,0828 6,2450 6,2450 5 5 4,7958 5,7446 5,3852 4,5826 4,1231 4,5826 5,7446 5,3852 5,1962 5,1962 4,7958 5,7446 5,9161 7,1414 6,0828 6,0828 6,4031 6,5574 6,2450 5,0990 4,2426 4,8990 5,1962 4,7958 4,3589 5,3852 5,3852 6,7082 6,0828 6,5574 6,4031 6,0828 6,1644 5,2915 4,8990 5,5678 5,7446 5,9161 5,3852 5 5,1962 5,3852 5,7446 5,9161 6,4031 6,5574 5,2915 5,3852 5,7446 5,1962 5,3852 5,1962 5,2915 0 4 5 4,5826 4,7958 5 5,7446 6,0828 5 4,5826 5 5,3852 5 5 4,7958 5,3852 5 6,4031 6,2450 5,7446 6,4031 6,2450 5,5678 6,0828 6,2450 5,9161 5 5 5 5,1962 5,5678 5 5 4,3589 5,5678 4,3589 5,9161 5,9161 5,5678 5,3852 5,5678 6,0828 6,2450 6,0828 4,5826 4,1231 5 5,3852 5,1962 4,7958 4,5826 4,5826 5,5678 5,5678 5,1962 5 4,5826 5,7446 5,5678 7 6,2450 5,9161 6,2450 6,4031 5,9161 4,6904 5,2915 4,8990 5,9161 5,5678 5 5,5678 5,3852 6,5574 6,0828 6,4031 6,2450 5,9161 6 5,4772 4,6904 6,0828 5,9161 5,9161 5,1962 5,1962 5,7446 5,3852 5,9161 5,7446 6,2450 6,2450 4,8990 5,5678 5,3852 5,3852 5,9161 5,7446 4,8990 4 0 CeMM Facts

To give you more information about CeMM we have gathered together all the practical details, i.e., the nuts and blots of the institute, which are presented here.

Here we proudly illustrate the diversity and ­characteristics of all the people working at CeMM, including their position, nationality, and gender. We also present an overview of CeMM publications, expenses and sources of funding in 2013. This is ­followed by our staff directory and a full publication list.

We will also introduce you to the Austrian ­Academy of Sciences and our current ­Scientific Advisory Board, who ­support us with their invaluable expertise. We also provide space to other notable people who helpfully imparted their thoughts and views on the institute in previous years in our ­widely anticipated ­Testimonials section. CeMM and the Austrian Members of the Academy of Sciences CeMM Scientific Advisory Board

The main building of the Austrian Academy of Sciences in the 1st district of Vienna.

The Austrian Academy of Sciences, founded Vienna and the General Hospital, CeMM is In strategic and scientific questions Prof. Dr. David Livingston (CHAIR) in 1847, is the major organisation promoting ­dedicated to its mission statement “from the CeMM is advised by a board of international Deputy Director, Dana-Farber/ non-university academic research institutions in clinic to the clinic” and fosters a highly collabora- top-scientists: Harvard Cancer Center, Boston, USA Austria. It developed from being a mere learned tive and interactive research mindset. Scientific society into an organisation promoting modern quality, innovation potential and sustainability Prof. Dr. William E. Paul scientific research institutions. In the awareness are the main criteria for its research profile, Prof. Dr. Richard Flavell Chief, Laboratory of Immunology, of its social, cultural and economic responsi- and made CeMM within a few years a flagship Chairman, Section of Immunobiology, National Institute of Allergy and bility, the Academy conducts basic research institute of the Academy and a key player for bio- Yale University School of Medicine, Infectious Diseases, Bethesda, USA which is open for practical applications, and its medical research in the heart of Europe, focusing New Haven, USA members support this function by making their on cancer, inflammation and immune disorders. Prof. Dr. Hidde Ploegh broad range of expertise available to the public Prof. Dr. James D. Griffin Member, Whitehead Institute for and advising decision makers in politics and The Austrian Academy of Sciences is promot- Chair, Department of Medical Oncology, Biomedical Research, Cambridge, USA business. The Academy is currently promoting ing a new quality in the dialogue with society Dana Farber Cancer Institute, Boston, USA 28 research institutions with more than 1300 and in the awareness for the societal impact of Prof. Dr. Nadia Rosenthal employees, which are located in several federal research and technological advancements and the Prof. Dr. Carl-Henrik Heldin Australian Regenerative Medicine Institute, states of ­Austria, with the headquarters in the importance of interdisciplinary and cross-cultural Director, Ludwig Institute for Cancer Research, Melbourne, AU Old ­University in the center of Vienna. approaches. In this respect CeMM is totally in Uppsala University, SE line with the goals of its mother organisation by Chairman of the Board of the Nobel Foundation Prof. Dr. Louis M. Staudt At the beginning of the new millennium, bringing together different disciplines, initiating Head, Molecular Biology of Lymphoid the Academy gave new impetus by taking up science and arts projects, popular lectures and Prof. Dr. Denis Hochstrasser Malignancies Section, National Institutes of Health, ­forward-looking research areas. CeMM was sociological, ethical and health-political debates, Head, Central Clinical Chemistry Laboratory, National Cancer Institute, Bethesda, USA founded as an interdisciplinary research institute for instance on the future of genome-informed Geneva University Hospital, CH committed to advancing the understanding of medicine. In the stunning 18th century frescoed human diseases through basic and biomedical festive hall of the Austrian Academy of ­Sciences research. Located in a tailor-made building in the (where Haydn and Beethoven conducted midst of the campus of the Medical University of ­premieres of their work) CeMM holds its yearly Landsteiner Lecture. Ce — M­—M­— Research Report 2013 Facts 105 106 When you’re trying to decide where to do your Georg Winter Ph.D., it helps to know what past and current Superti-Furga Lab: 2008 – 2013 Ph.D. Program students think of the CeMM Ph.D. Program Current Position: Postdoctoral research fellow experience. Here some CeMM students, past and Dana Farber Cancer Institute/Harvard Medical present, share their thoughts with you to give School, USA you “the insider” perspective on some of the “Reflecting on my time as a Ph.D. student is The CeMM Ph.D. Program trains a new gen- Translational research highlights of being a CeMM Ph.D. student. ­certainly looking back with a smile and I can eration of researchers based on a novel, post- CeMM’s mission is to combine insight obtained say that for me, CeMM was, in many different genomic, molecular understanding of biological from basic and clinical research and use it to Elisabeth Salzer aspects, just the best spot to pursue my ­studies and pathological systems and will thereby implement the development of innovative Boztug Lab: 2010 – ­present and a perfect match from the first day on. CeMM ­contribute to shaping the predictive, preventive ­therapeutic and diagnostic strategies – from “My decision to do a Ph.D. after finishing ­medical was unique in its capability of providing me and ­personalized (also termed “precise”) medi- the clinic to the clinic. CeMM is positioned studies was mainly based on the fact that as a access to cutting-edge technologies, a good cine of the future. To reach this goal, students in ­medically-oriented research. In its short medical doctor you are often confronted with funding situation and great expertise in a broad are made familiar not only with biomedical history it has published a growing series facts about disease entities, causalities or treat- scope of scientific genres, all three of which are technologies, but also with the basic principles of of “­translationally” relevant publications­ ments you have to study, internalize and apply key features to succeed in science. I learned how cell- and molecular biology and the application (e.g. a Nature paper on acute macular degenera- but you are not really supposed to challenge­ much I can benefit from working together with of this knowledge for a molecular understanding tion mechanism by ­Weisman et al., or a NEJM them. Therefore I decided to do a Ph.D. in talented people experienced in very specialized of ­diseases and targeted therapeutic concepts. paper that brings hope to many MPN patients; ­molecular biology before starting my medical fields like bioinformatics, genomics or protein The Ph.D. students also learn how to navigate a newly identified ­mutation fills the gap in the specialization to broaden my scientific horizon mass spectrometry. Given the international focus the complexity of translationally-minded multi­ molecular ­pathogenesis of MPN by Klampfl and to get a profound education in science. It of CeMM, it was easy for me to attend scientific disciplinary biomedical projects at the level of et al.). was important for me to work in an institute, conferences in Europe and the USA that allowed communication and management. which is tightly interconnected with clinicians me to further expand my professional network Inter-group collaboration and focused on clinically applicable research which, in turn, also helped me to find my current With 13 successful research groups on-site, but at the same time also known for cutting- position.” Access to top technology CeMM’s students benefit from the experience edge ­technologies and great expertise in a broad CeMM offers a range of cutting-edge techno- and expertise of a diverse range of research scope of scientific genres. Now, after three years logical platforms for modern post-genomic ­scientists. CeMM offers a collaborative culture, at CeMM I can say it is indeed a truly unique ­methods – including deep sequencing, according to which students, postdocs and PIs place in many ways. The atmosphere is inter- ­proteomics, ­chemical biology, a virology lab contribute their expertise generously while national and very open-minded also towards and access to imaging and sorting, biological- accessing the expertise of all others in a ­modular non-­biological topics such as music, arts and chip technologies and bioinformatics. CeMM’s fashion to lead multi-disciplinary projects humanities.” ­expertise and state-of-the-art instrumentation ­efficiently and professionally. are accessible to all its employees. Emphasis Thorsten Klampfl is given to unusually strong support through For further information including application Kralovics Lab: 2008 – 2013 freedom and scientific infrastructure as well as deadlines please visit: Current Position: Postdoctoral research associate supervision and administrative services that are http://www.cemm.oeaw.ac.at/phd-program/ University of Cambridge, UK needed to carry out the proposed project for the “The highlight of my Ph.D. was, of course, when entire duration of the Ph.D. Program. all of my hard work and experiments bared fruit and contributed to ground breaking findings. Making use of the possibilities at CeMM I had the privilege to identify novel mutations that contribute to specific blood cancers which we studied in Robert Kralovics’ lab. In an ­incredible group effort, with the selfless dedication of my fantastic colleagues in the lab and with the help of collaborators within and outside CeMM, we studied these mutations for their bio­logical Georg Winter in the and clinical implications. The findings will Superti-Furga Lab ­contribute to a better diagnosis of the disease and will lay the foundation for development of new therapies. Just recently the paper describing this research was accepted for publication in the New England Journal of Medicine and it is said to ­represent a landmark paper for the understanding of the blood cancers we studied.”

Ce — M­—M­— Research Report 2013 Facts 107 108 Employees

34 Nationalities Austria, Algeria, Armenia, Australia, Brazil, China, Colombia, Croatia, Cyprus, Czech Republic, DR Congo, ­Finland, France, Germany, Greece, Hungary, India, ­Ireland, Italy, Lebanon, Lithuania,­ New Zealand,­ Poland,­ Portugal, Russia,­ Serbia,­ Singapore,­ Slovakia,­ South ­Korea, Spain, Switzerland, The ­Netherlands, United Kingdom, United States

Staff Scientist Scientific Support Legend of Grants FWF F47 Special Research ­Program Andrè Müller Sylvia Bolz CDL “Chemical Epigenetics ­ Directory “­Myeloproliferative Wash & Media Kitchen and Anti-Infectives” ­Neoplasms” Christian Doppler Laboratory Technical Assistants Amisi Fundi Nyembo “Chemical Epigenetics and FWF J3269 ESF Wash & Media Kitchen Ivan Bilic Anti-Infectives” FWF J3269 Erwin Schrödinger ERC SG “ImmunoCore” Sabine Jungwirth Fellowship Management Freya Klepsch Ph.D. and Diploma Students Blanka Kubesova DAAD Fellowship CeMM Technical Assistant JDRF Grant Klaudia Bagienski* German Academic Exchange FWF P22282 Giulio Superti-Furga, Tim Alber Tomasz Kulinski FWF F47 Paul Kletzl Service (DAAD) Fellowship Stand Alone Project Scientific Director Tomasz Konopka FWF W1207 Amir Shazada Internal Logistics “­Regulo-Interactome Modules ERC SG “Genes.Drugs.Cancer” Tiina Berg EMBO Long Term Fellowship Gerhard Schadler*, MedUni Vienna Jin Li of Hematopoetic Stem Cells” Sarah Niggemeyer Managing Director Peter Màjek JDRF Grant Manuela Bruckner ERC AdG I-FIVE Daniel Andergassen* CeMM Technical Assistant FWF P23257 ERC PoC AIRSHIP ERC Advanced Investigator Anita Ender, Markus Müllner Marco Licciardello Stand Alone Project Sol A Ban* Gabriel O’Riordain Grant “i-FIVE – Interferon- Administrative Director ERC SG “Genes.Drugs.Cancer” EU MCCIG EPICAL Rita Casari “­Heriditary Predispositions to Team Leader Scientific Support focused Innate Immunity Philipp Bammer FWF P25185 ­Myeloproliferate Neoplasms” Georg Casari Harini Nivarthi Barbara Maier Interactome and Inhibitome” FWF P25185 Anton Peisser Intellectual Property & FWF F28 MedUni Vienna Albert Coll Manzano* FWF P23991 Caretaker ERC PoC AIRSHIP Technology­ Transfer Lisa Bauer Stand Alone Project Nikolina Papac-Milicevic Julia Maier Essi Eminger* ERC Proof of Concept Grant Patrick Stangl “Role of Oxidative Stress MedUni Vienna Anannya Bhattacharya MedUni Vienna FWF P24999 “AIRSHIP – Acute Inflammation Purchaser in Viral Hepatitis” Principal Investigators ÖAW Doc-Fellowship Resolution by Soluble Human Angelo Nuzzo Barbara Mair Wojciech Garncarz Inhibitory Protein” Denise P. Barlow Johannes Bigenzahn ÖAW Doc-Fellowship FWF P24999 FWF P24217 Florian Pauler Stand Alone Project Administration ERC Starting Grant “Genes. Andreas Bergthaler FWF F43 Bernd Boidol Rui Martins Laura Göderle “Regulation of innate Drugs.Cancer” CDL “Chemical Epigenetics and MedUni Vienna MedUni Vienna Denise Artner Christoph J. Binder Jana Prochazkova ­immunity by DEAD box Anti-Infectives” Accountant ERC SG “ImmunoCore” FWF P24766 Daniela Mayer* Manuela Gridling RNA helicase DDX3X” Christoph Bock Florian Breitwieser*# EU ASSET Mitra Eva Baghai ERC Starting Grant Manuele Rebsamen Abdelghani Mazouzi FWF P24321 Kaan Boztug FWF P24321 Personal Assistant “ImmunoCore”­ EMBO Long Term Fellowship FWF P24766 Johanna Hadler Stand Alone Project ­ Sylvia Knapp Laura Brückner* Sonja Baier EU MCCIG EPICAL “Statistical Modeling of Protein Roberto Sacco Jelena Milosevic Tatjana Therese Hirschmugl EU MCCIG EPICAL Assistant EU Marie Curie Career ­Modification Regulation” Joanna Loizou FWF P24217 FWF P23257 ERC SG “ImmunoCore” ­Integration Grant “EPICAL- Clara Jana Busch Marlene Berdnik* FWF P24766 Robert Kralovics Erika Schirghuber Anna Moskovskich Anastasiya Hladik of Epigenetic Cancer Lesions Assistant Stand Alone Project “Molecular Elisangela Calheiro FWF W1205 MedUni Vienna by Chemical Biology and Sebastian Nijman CDL “Chemical Epigenetics Characterization of Non- and Anti-Infectives” dos Santos Valente° Marc Jochen Brehme ­Functional Genomics” Markus Muckenhuber Marie Huber Canonical ATM Signaling” Giulio Superti-Furga Scientific Assistant to Christopher Schliehe Adrián César Razquin FWF P25185 FWF P24217 EU Project “OPENSCREEN: the Director FWF P24999 DAAD Fellowship European Infrastructure of Ciara Cleary Michel Owusu Claudia Kerzendorfer Stand Alone Project Department Heads Stephan Boos-Waldeck Open Screening Platforms for Christian Schmidl FWF P23257 FWF P24766 FWF F47 “­Inflammatory Bowel Disease” Team Leader Accounting Chemical Biology” Keiryn L. Bennett EU Project “BLUEPRINT” FWF P25185 Paul Datlinger Tanja Plessl* Ruth Klement EU ASSET Angelika Eisner Stand Alone Project Jacques Colinge Michael Schuster EU Project “ASSET – Analysing Cecilia Dominguez Conde Nina Prengemann Christian Knoll* Grant Manager “Long non-coding RNA” Stefan Kubicek Sara Sdelci FWF P24999 FWF P24999 and Striking the Sensitivities Justyna Konecka Binia Günther JDRF Grant of Embryonal Tumours” FWF P25360 Christoph Dotter Ana Pujda HR Manager Lindsay Kosack Stand Alona Proejct “Antiviral Adjunct Omar Sharif EU Project “BLUEPRINT” Carol-Ann Eberle Branka Radic FWF P23991 Julia Kronschläger* Immune Response” Principal Investigator FWF P25801 FWF W1205 EU ASSET Internship EU HEM-ID Vesna Krajina FWF P25801 Stand Alone Thijn Brummelkamp Nathan Clark Sheffield EU Project “HEM-ID – Astrid Fauster Udochuku Richson* MedUni Vienna Victoria Kulcsar-Mecsery ­Project “The Role of TREM-2 EU Project “BLUEPRINT” ­HEMatopoietic cell IDentity:­ Accountant in Pneumonia” Ferran Fece de la Cruz Simona Saluzzo Charles-Hugues Lardeau genetic and epigenetic PostDoctoral Fellows Michal Smida FWF W1205 CDL “Chemical Epigenetics and Catherine May Lloyd ­regulation in normal and FWF W1205 Stefanie Flores Klaver Barbara Drobits Berend Snijder Anti-Infectives” Ph.D. and Postdoc Program malignant ­hematopoiesis” Doctoral Program “CCHD – Cell Elisabeth Salzer Swiss National Fund Bianca Gapp Manager Communication in Health and Doris Chen ERC SG ImmunoCore Hannelore Lechtermann* FWF F28 Fellowship­ Disease” Riem Gawish Michael Pilz Special Research Program Matthias Farlik Federica Santoro*# Ernestine Leitner* FWF W1205 Team Leader IT Services “Jak-Stat – Signalling from FWF W1207 Alexey Stukalov JDRF Grant Adriana Goncalves*# Fiorella Schischlik Basis to Disease” Doctoral Program Roberto Giambruno Michael Ruepp Chris Soon Heng Tan Katalin Nagyen-Bojarszky ­“Bioinformatics Maria Gorna Luisa Schmidt* Scientific Cluster Support FWF F43 FWF F47 Anna Dorothea Gorki* OeNB Integration Network III” ERC AdG I-FIVE Special Research Program FWF W1205 Andreas Schönegger Camilo Sánchez Claudia Trefzer Nadine Olk “RNA regulation of the JDRF Grant Florian Grebien Project Collaborator for Swiss National Fund Isabel Grießhammer* Melanie Six* ­transcriptome” Juvenile Diabetes Research FWF P22282 Maria Ozsvar-Kozma Finance­ & Controlling, Fellowship­ FWF P23991 JDRF Grant Foundation Canada Barbara Gritti MedUni Vienna EU OPENSCREEN Georgia Velimezi Sabrina Gruber Anna Skucha ÖAW Doc-Fellowship MedUni Vienna Katja Parapatics Eva Schweng Swiss National Fund EU HEM-ID Doctoral Fellowship Program Philipp Günzl Leonhard Heinz Fellowship­ ERC AdG I-FIVE Team Leader Public Relations of the Austrian Academy of ÖAW Doc Fellowship Katia Sleiman ERC PoC AIRSHIP Bojan Vilagos Thomas Penz Sigrid Strodl Sciences Karin Harold Nicole Them Barbara Herdy FWF P25360 Melanie Planyavsky Team Leader OeNB MedUni Vienna FWF P23257 ERC AdG I-FIVE Finance & Controlling­ OeNB Jubiläumsfonds Gregory Ian Vladimer Adrijana Stefanovic Ashot Harutyunyan*# Dimitris Tsiantoulas “­Resistenz gegen PI3K/m TOR Kilian Huber EMBO Long Term Fellowship Joachim Tröster FWF P23257 MedUni Vienna Karin Lakovits Inhibitoren bei Brustkrebs” EU ASSET IT Administrator Katharina Willmann MedUni Vienna Andrea Hildebrandt* Dijana Vitko Quanah Hudson ERC SG “ImmunoCore” Rebecca Wutzler* Tamara Theil* Assistant to Principal FWF P25185 Katrin Hörmann Tanja Walgram* FWF P24321 Sarah Vittori* Investigators­ Roland Jäger Juliane Weißer FWF J3269 ESF Christine Jandrasits* Katarzyna Warczok Terje Wimberger # graduated 2013 Kumaran Kandasamy Kseniya Khamina MedUni Vienna Marc Wiedner ERC AdG I-FIVE * left CeMM in 2013 Mate Kiss Georg Winter*# Alexandra Zisser Thomas Karonitsch FWF W1205 ° parental leave or ­ Stavroula Woutsas Interdisciplinary PostDoc, educational leave Thorsten Klampfl*# ERC AdG I-FIVE Marielle Klein Johanna Klughammer Aleksandra Kornienko FWF F43 Ce — M­—M­— Research Report 2013 Facts 115 116 15. Mellacheruvu D, Wright Z, Couzens AL, 22. Rumi E, Milosevic JD, Casetti I, Dambruoso I, Lambert J-P, St-Denis N, Li T, Mitev YV, Hauri S, Pietra D, Boveri E, Boni M, Bernasconi P, Publications 2013 Sardiu ME, Low TY, Halim VA, Bagshaw RD, ­Passamonti F, Kralovics R, Cazzola M. Efficacy Hubner NC, al-Hakim A, Bouchard A, Faubert D, of ruxolitinib in chronic eosinophilic leukemia Fermin D, Dunham WH, Goudreault M, associated with a PCM1-JAK2 fusion gene. 1. Lichtman AH, Binder CJ, Tsimikas S, 8. Gisslinger H, Gotic M, Holowiecki J, Lin Z-Y, Gonzalez Badillo B, Pawson T, J Clin Oncol. 2013 Jun 10;31(17):e269-71. ­Witztum JL. Adaptive immunity in Penka M, Thiele J, Kvasnicka H-M, Kralovics R, ­Durocher D, ­Coulombe B, Aebersold R, ­athero­genesis: new insights and therapeutic Petrides PE, Gastl G, Gisslinger B, Muellauer L, ­Superti-Furga S, ­Colinge J, Heck AJR, Choi 23. De Keersmaecker K, Porcu M, Cox L, ­approaches. J Clin Invest. 2013 Jan 2;123(1):27-36. Schlögl E, Indrak K, Pytlik R, Briere K, ­ H, Gstaiger M, Mohammed S, Cristea IM, Girardi T, Vandepoel R, Op de Beeck J, Gielen O, Kiladjian JJ, Beykirch M, Gaede B, ­Bennett KL, Washburn MP, Raught B, Mentens N, Bennett KL, Hantschel O. NUP214- 2. Rudashevskaya EL, Sacco R, Kratochwill K, Griesshammer M, ­Herbrik-Zipp M, Hurtz HJ, Ewing RM, Gingras A-C, Nesvizhskii A. The ABL1 mediated cell proliferation in T-cell acute Huber ML, Gstaiger M, Superti-Furga G, ­ Jacobs G, Jäcki SH, Keilholz U, Mezger J, CRAPome: a Contaminant Repository for lymphoblastic leukemia is dependent on the Bennett KL. A method to resolve the Schlag P, Schriever F, Masszi T, Sacchi S, ­ ­Affinity ­Purification Mass Spectrometry Data. LCK kinase and various interacting proteins. composition­ of heterogeneous­ affinity-purified­ Griniptì R ,Tavoriene I, ­Dmoszynska A, ­ Nature Methods. May. 24(Suppl):S50-S51. ­Haematologica. Jan;99(1):85-93. protein ­complexes assembled around a ­ Hellman A, Jedrzejczak WW, Robak T, common protein by chemical cross-linking, ­SkotnickiA, Goh YT, Cernelc P. Anagrelide 16. Unger S, Górna MW, Le Béchec A, 24. Dürnberger G, Bürckstümmer T, Huber K, gel ­electrophoresis and mass spectrometry. compared with hydroxyurea in WHO-classified Do Vale-Pereira S, Bedeschi MF, Geiberger S, Giambruno R, Doerks T, Karayel E, Burkard TR, Nat Protoc. 2013 Jan;8(1):75-97. essential thrombocythemia: the ANAHYDRET Grigelioniene G, Horemuzova E, Lalatta F, Kaupe I, Müller AC, Schönegger A, Ecker GF, Study, a randomized controlled trial. Blood. Lausch E, Magnani C, Nampoothiri S, Lohninger H, Bork P, Bennett KL, 3. Vizcaíno JA, Côté RG, Csordas A, Dianes JA, 2013 March 7;121(10):1720-1728. Nishimura G, Petrella D, Rojas-Ringeling F, Superti-Furga G, Colinge J. Experimental Fabregat A, Foster JM, Griss J, Alpi E, Birim M, Utsunomiya A, Zabel B, Pradervand S, ­ ­characterization of the human non-sequence- Contell J, O’Kelly J, Schoenegger A, Ovelleiro D, 9. Santoro F, Mayer D, Klement RM, ­ Harshman K, Campos-Xavier B, Bonafé L, specific nucleic acid interactome. Genome Biol. Pérez-Riverol Y, Reisinger F, Ríos D, Wang R, Warczok KE, Stukalov A, Barlow DP, Pauler FM. Superti-Furga G, Stevenson B, Superti-Furga A. 2013 Jul 31;14(7):R81. Hermjakob H. The Proteomics Identifications­ ­Imprinted Igf2r silencing depends on continuous FAM111A Mutations Result in Hypoparathy- (PRIDE) database and associated­ tools: ­status in Airn lncRNA expression and is not restricted to a roidism and Impaired Skeletal Development. 25. Matt U, Sharif O, Martins R, Furtner T, 2013. Nucleic Acids Res. 2013 January;41(D1): developmental window. Development. Am J Hum Genet. 2013 Jun 6;92(6):990-5. Langeberg L, Gawish R, Elbau I, Zivkovic A, D1063-D1069. 2013 Mar;140(6):1184-95. Lakovits A, Oskolkova O, Doninger B, 17. Zielinski C, Knapp S, Mascaux C, Hirsch F. Vychytil A, Perkmann T, Schabbauer G, 4. Abbas YM, Pichlmair A, Górna MW, 10. Santoro F, Pauler FM. Silencing by the Rationale for targeting the immune system Binder CJ, Bochkov VN, Scott JD, Knapp S. Superti-Furga G, Nagar B. Structural basis for imprinted Airn macro lncRNA. Cell Cycle. through checkpoint molecule blockade in the WAVE1 mediates suppression of phagocytosis viral 5’-PPP-RNA recognition by human IFIT 2013 March 1;12(5):711-712. treatment of non-small-cell lung cancer. by phospholipid-derived DAMPs. J Clin Invest. proteins. Nature. 2013 Feb 7; 494(7435):60-4. Ann Oncol. 2013 May;24(5):1170-1179. 2013 July 1;123(7):3014-3024. 11. Cao K, Lailler N, Zhang Y, Kumar Y, Uppal K, 5. Boztug K, Klein C. Genetics and patho- Liu Z, Lee EK, Wu H, Medrzycki M, Pan C, 18. Borgdorff V, Rix U, Winter GE, Gridling M, 26. Rebsamen M, Kandasamy RK, physiology of severe congenital neutropenia­ Ho P-Y, Cooper GP Jr, Dong X, Bock C, Müller AC, Breitwieser FP, Wagner C, Colinge J, Superti-Furga G. Protein interaction networks ­syndromes unrelated to neutrophil elastase. ­Bouhassira EE, Fan Y. High-Resolution Mapping Bennett KL, Superti-Furga G, Wagner SN. in innate immunity. Trends Immunol. Hematol Oncol Clin North Am. of H1 Linker Histone Variants in Embryonic Stem A chemical biology approach identifies AMPK 2013 Jul 1. S1471-4906(13)00079-3 2013 Feb;27(1):43-60, vii. Cells. PLoS Genet. 2013 April;9(4):e1003417. as a modulator of melanoma oncogene MITF. Oncogene.­ 2014 May 8;33(19):2531-9. Epub 27. Rommer A, Steinleitner K, Hackl H, 6. Kretschy N, Teichmann M, Kopf S, 12. Salzer E, Santos-Valente E, Klaver S, Ban SA, 2013 Jun 3. ­Schneckenleithner C, Engelmann M, Atanasov AG, Saiko P, Vonach C, Viola K, Emminger W, Prengemann NK, Garncarz W, Scheideler M, Vlatkovic I, Kralovics K, ­Giessrigl B, Huttary N, Raab I, Krieger S, Müllauer L, Kain R, Boztug H, Heitger A, 19. Fischer MT, Wimmer I, Höftberger R, ­Cerny-Reiterer, Valent P, Sill H, Wieser R. Jäger W, Szekeres T, Nijman SM, Mikulits W, ­Arbeiter K, Eitelberger F, Seidel MG, Holter W, ­Gerlach S, Haider L, Zrzavy T, Hametner S, ­Overexpression of primary microRNA 221/222 Dirsch VM, Dolznig H, Grusch M, Krupitza G. Pollak A, Pickl WF, Förster-Waldl E, Boztug K. Mahad D, Binder CJ, Krumbholz M, Bauer J, in acute myeloid leukemia. BMC Cancer. In vitro inhibition of breast cancer spheroid- B-cell deficiency and severe autoimmunity Bradl M, Lassmann H. Disease-specific molecular 2013;13:364. induced lymphendothelial defects resembling caused by deficiency of protein kinase Cδ . Blood. events in cortical multiple sclerosis lesions. Brain. intravasation into the lymphatic vasculature 2013 April 18;121(16). 2013 June;136(6):1799-1815. 28. Bieghs V, Walenbergh SM, Hendrikx T, by acetohexamide, isoxsuprine,­ nifedipin and van Gorp PJ, Verheyen F, Olde Damink SW, proadifen. Br J Cancer. 2013 Feb 19;108(3):570-8. 13. Varjosalo M, Sacco R, Stukalov A, 20. Kulinski TM, Barlow DB, Hudson Q. Masclee AA, Koek GH, Hofker MH, Binder CJ, van Drogen A, Planyavsky M, Hauri S, Imprinted silencing is extended over broad Shiri-Sverdlov R. Trapping of oxidized LDL in 7. Rudashevskaya EL, Breitwieser FP, Huber ML, Aebersold R, Bennett KL, Colinge J, Gstaiger M, ­chromosomal domains in mouse extra-­ lysosomes of Kupffer cells is a trigger for hepatic Colinge J, Müller AC, Bennett KL. Multiple­ and Superti-Furga G. Interlaboratory reproducibility embryonic lineages. Curr Opin Cell Biol. inflammation. Liver Int. 2013 Aug;33(7):1056-61. sequential data acquisition method: an improved of large-scale human protein-complex analysis 2013 June;25(3):297-304. method for fragmentation and detection­ of by standardized AP-MS. Nat Methods. 29. Herwig R, Knoll C, Planyavsky M, cross-linked peptides on a hybrid linear trap 2013 Apr;10(4):307-14. 21. Que X, Widhopf II GF, Amir S, ­Pourbiabany A, Greilberger J, Bennett KL. ­quadrupole Orbitrap Velos mass spectrometer.­ Hartvigsen K, Hansen LF, Woelkers D, ­Proteomic analysis of seminal plasma from Anal Chem. 2013 Feb 5;85(3):1454-61. 14. Kornienko AE, Guenzl PM, Barlow DP, Tsimikas S, Binder CJ, Kipps TJ, Witztum JL. ­infertile patients with oligoasthenoteratozoo- Pauler FM. Gene regulation by the act of long IGHV1-69-Encoded Antibodies Expressed in spermia due to oxidative stress and comparison non-coding RNA transcription. BMC Biol. Chronic Lymphocytic Leukemia React with with fertile volunteers. Fertil Steril. 2013;11:59. Publ. May 30 Malondialdehyde-Acetaldehyde Adduct, an 2013 Aug;100(2):355-66.e2. Immunodominant Oxidation-Specific Epitope. PLoS One. 2013;8(6):e65203. Publ. 20 Jun

Ce — M­—M­— Research Report 2013 Facts 117 118 30. Kollmann K, Heller G, Schneckenleithner C, 37. Hennig C, Ilginus C, Boztug K, Skokowa J, 43. Karper JC, de Jager SC, Ewing MM, 50. Klampfl T, Gisslinger H, Harutyunyan AS, Warsch W, Scheicher R, Ott RG, Schäfer M, Marodi L, Szaflarska A, Sass M, Pignata C, de Vries MR, Bot I, van Santbrink PJ, Redeker A, Nivarthi H, Rumi E, Milosevic JD, Them NC, ­Fajmann S, Schlederer M, Schiefer A-I, Kilic SS, Caragol I, Baumann U, Klein C, Mallat Z, Binder CJ, Arens R, Jukema JW, Berg T, Gisslinger B, Pietra D, Chen D, ­ Reichart U, Mayerhofer M, Hoeller C, Welte K, Hansen G. High-content cytometry Kuiper J, Quax PH. An unexpected ­intriguing Vladimer GI, Bagienski K, Milanesi C, Casetti IC, ­Zöchbauer-Müller C, Kerjaschki D, Bock C, and transcriptomic biomarker profiling of human effect of Toll-like receptor regulator RP105 Sant’Antonio E, Ferretti V, Elena C, Schischlik F, Kenner L, Hoefler G, Freissmuth M, Green AR, B-cell activation. J Allergy Clin Immunol. (CD180) on atherosclerosis formation with Cleary C, Six M, Schalling M, Schönegger A, Moriggl R, Busslinger M, Malumbres M, Sexl V. 2014 Jan;133(1):172-80.e1-10. Epub 2013 Sep 5. ­alterations on B-cell activation. Arterioscler Bock C, Malcovati L, Pascutto C, Superti-Furga G, A Kinase-Independent Function of CDK6 Links Thromb Vasc Biol. 2013 Dec;33(12):2810-7. Cazzola M, Kralovics R. Somatic mutations of the Cell Cycle to Tumor Angiogenesis. 38. Kreutzfeldt M, Bergthaler A, Fernandez M, calreticulin in myeloproliferative neoplasms. Cancer Cell. 2013 August 12;24(2):167-181. Brück W, Steinbach K, Vorm M, Coras R, 44. Montano EN, Boullier A, Almazan F, N Engl J Med. 2013 Dec 19;369(25):2379-90. Epub ­Blümcke I, Bonilla WV, Fleige A, Forman R, Binder CJ, Witztum JL, Hartvigsen K. 2013 Dec 10. 31. Warszawska JM, Gawish R, Sharif O, ­Müller W, Becher B, Misgeld T, ­Development and application of a nonradioactive­ Sigel S, Doninger B, Lakovits K, Mesteri I, Kerschensteiner M, Pinschewer DD, Merkler D. binding assay of oxidized low-density 51. Liehl P, Zuzarte-Luís V, Chan J, Zillinger T, Nairz M, Boon L, Spiel A, Fuhrmann V, Neuroprotective intervention by interferon-γ ­lipoprotein to macrophage scavenger receptors. Baptista F, Carapau D, Konert M, Hanson KK, Strobl B, Müller M, Schenk P, Weiss G, Knapp S. blockade prevents CD8+ T cell-mediated J Lipid Res. 2013 Nov;54(11):3206-3214. Carret C, Lassnig C, Müller M, Kalinke U, ­Lipocalin 2 deactivates macrophages and ­dendrite and synapse loss. J Exp Med. Saeed M, Chora AF, Golenbock DT, Strobl B, ­worsens pneumococcal pneumonia outcomes. 2013 Sep 23;210(10):2087-103. 45. Upadhyay AS, Vonderstein K, Pichlmair A, Prudêncio M, Coelho LP, Kappe SH, J Clin Invest. 2013 August 1;123(8). Stehling O, Bennett KL, Dobler G, Guo JT, Superti-Furga G, Pichlmair A, Vigário AM, 39. Cleary C, Kralovics R. Molecular basis Superti-Furga G, Lill R, Overby AK, Weber F. Rice CM, Fitzgerald KA, Barchet W, Mota MM. 32. Bürckstümmer T, Banning C, Hainzl P, and clonal evolution of myeloproliferative Viperin is an iron-sulfur protein that inhibits Host-cell sensors for Plasmodium activate innate Schobesberger R, Kerzendorfer C, Pauler FM, neoplasms.­ Clin Chem Lab Med. genome synthesis of tick-borne encephalitis virus immunity against liver-stage infection. Nat Med. Chen D, Them N, Schischlik F, Rebsamen M, 2013 Oct 1;51(10):1889-96. via radical SAM domain activity. Cell Microbiol. 2014 Jan;20(1):47-53. Epub 2013 Dec 22. Smida M, Fece de la Cruz F, Lapao A, Liszt M, 2014 Jun;16(6):834-48. Epub 2013 Dec 3. Eizinger B, Guenzl PM, Blomen VA, Konopka T, 40. Rix U, Colinge J, Blatt K, Gridling M, 52. Fritzsche R, Karra D, Bennett KL, Ang FY, Gapp B, Parapatics K, Maier B, Stöckl J, Fischl W, ­Remsing Rix LL, Parapatics K, Cerny-Reiterer S, 46. Li J, Bennett K, Stukalov A, Fang B, Zhang G, Heraud-Farlow JE, Tolino M, Doyle M, Bauer KE, Salic S, Taba Casari MR, Knapp S, Bennett KL, Burkard TR, Jäger U, Melo J, Bennett KL, Yoshida T, Okamoto I, Kim JY, Song L, Bai Y, Thomas S, Planyavsky M, Arn E, Bakosova A, Bock C, Colinge J, Kralovics R, Ammerer G, Valent P, Superti-Furga G. A Target-Disease Qian X, Rawal B, Schell M, Grebien F, Winter G, Jungwirth K, Hörmann A, Palfi Z, Sandholzer J, Casari G, Brummelkamp TR, Superti-Furga G, Network Model of Second-Generation BCR-ABL Rix U, Eschrich S, Colinge J, Koomen J, Schwarz M, Macchi P, Colinge J, Superti-Furga G, Nijman SM. A reversible gene trap collection Inhibitor Action in Ph+ ALL. PLoS One. Superti-Furga G, Haura EB. Perturbation of Kiebler MA. Interactome of two diverse RNA empowers haploid genetics in human cells. 2013;8(10):e77155. Publ 10 Oct. the mutated EGFR interactome identifies granules links mRNA localization to ­translational Nat Methods. 2013 Oct;10(10):965-71. ­vulnerabilities and resistance mechanisms. repression in neurons. Cell Rep. 41. Zouggari Y, Ait-Oufella H, Bonnin P, Mol Syst Biol. 2013 Nov 5;9:705. 2013 Dec 26;5(6):1749-62. 33. Breitwieser F, Colinge J. IsobarPTM: A Simon T, Sage AP, Guérin C, Vilar J, ­software tool for the quantitative analysis of Caligiuri G, Tsiantoulas D, Laurans L, Dumeau E, 47. Gisslinger H, Schalling M, Gisslinger B, 53. Rumi E, Pietra D, Ferretti V, Klampfl T, post-translationally modified proteins. Kotti S, Bruneval P, Charo IF, Binder CJ, Skrabs C, Müllauer L, Kralovics R. Restoration of Harutyunyan AS, Milosevic JD, Them NC, J Proteomics. 2013 September 2;90(100):77-84. Danchin N, Tedgui A, Tedder TF, Silvestre JS, response to ruxolitinib upon brief withdrawal in Berg T, Elena C, Casetti IC, Milanesi C, Mallat Z. B lymphocytes trigger monocyte two patients with myelofibrosis. Am J Hematol. Sant’antonio E, Bellini M, Fugazza E, Renna MC, 34. Chamrád I, Rix U, Stukalov A, Gridling M, ­mobilization and impair heart function after 2014 Mar;89(3):344-6. Epub 2013 Nov 25. Boveri E, Astori C, Pascutto C, Kralovics R, Parapatics K, Müller AC, Altiok S, Colinge J, acute myocardial infarction. Nat Med. ­Cazzola M. JAK2 or CALR mutation status Superti-Furga G, Haura EB, Bennett KL. 2013 Oct;19(10):1273-1280. 48. Nijman SM, Friend SH. Cancer. ­Potential defines subtypes of essential thrombocythemia A ­miniaturized chemical proteomic approach of the synthetic lethality principle. ­Science. with substantially different clinical course and for target profiling of clinical kinase inhibitors 42. Michels KB, Binder AM, Dedeurwaerder S, 2013 Nov 15;342(6160):809-11. outcomes. Blood. 2014 Mar 6;123(10):1544-51. in tumor biopsies. J Proteome Res. Epstein CB, Greally JM, Gut I, Houseman EA, Epub 2013 Dec 23. 2013 Sep 6;12(9):4005-17. Izzi B, Kelsey KT, Meissner A, Milosavljevic­ A, 49. Berger A, Hoelbl-Kovacic A, Bourgeais J, Siegmund KD, Bock C, Irizarry RA. Hoefling L, Warsch W, Grundschober E, Uras IZ, 54. Them NC, Kralovics R. Genetic Basis of 35. Colinge J. Systems Biology Analysis of ­Recommendations for the design and analysis Menzl I, Putz EM, Hoermann G, Schuster C, MPN: Beyond JAK2-V617F. Kinase Inhibitor Action in Leukemia Treatments. of epigenome-wide association studies. ­Fajmann S, Leitner E, Kubicek S, Moriggl R, Curr Hematol Malig Rep. 2013 Dec;8(4):299-306. Biomed Tech (Berl). Nat Methods. 2013 Oct;10(10):949-55. Gouilleux F, Sexl V. PAK-dependent STAT5 2013 Sep 7.10.1515/bmt-2013-4306 ­serine phosphorylation is required for BCR-­­ABL- 55. Hendrikx T, Bieghs V, Walenbergh SM, induced leukemogenesis. Leukemia. van Gorp PJ, Verheyen F, Jeurissen ML, 36. Giambruno R, Grebien F, Stukalov A, 2014 Mar;28(3):629-41. Epub 2013 Nov 22. ­Steinbusch MM, Vaes N, Binder CJ, Koek GH, Knoll C, Planyavsky M, Rudashevskaya EL, Stienstra R, Netea MG, Hofker MH, Colinge J, Superti-Furga G, Bennett KL. Affinity Shiri-Sverdlov R. Macrophage Specific Purification Strategies for Proteomic Analysis of ­Caspase-1/11 Deficiency Protects against Transcription Factor Complexes. J Proteome Res. ­Cholesterol Crystallization and Hepatic 2013 Sep 6;12(9):4018-4027. ­Inflammation in Hyperlipidemic Mice. PLoS One. 2013 Dec 2;8(12):e78792.

Ce — M­—M­— Research Report 2013 Facts 119 120 Inclusiveness at CeMM CeMM has a strong intellectual environment Staff that stems from the international nature of its employees. Diversity and different cultural Listed by number of persons per field of work CeMM stresses keeping the Facts & administration very lean and backgrounds are a clear advantage to successful efficient. We have a very good gender balance, with a research, collaborations, and the day-to-day small surplus of women (57%). The average age is 31,76 years. business, as long as everyone follows a few basic Management 3 persons Figures principles, which at CeMM are: Professionalism, 2% of total staff Politeness and Persistence. The working ­language at CeMM is English. Scientific Support 8 persons 4% of total staff At CeMM, emphasis is given to mentoring independent young investigators and scientists Lab Heads 13 persons early in their careers, through freedom, 6% of total staff ­availability of infrastructure and a strong ­support system. A flat hierarchy, where the Administration 18 persons input of every single person is appreciated 9% of total staff and required, leads to an enjoyable work ­environment and an increase in productivity Diploma and Guest Students 23 persons and ideas. 12% of total staff

CeMM is particularly interested in supporting and fostering women scientists in areas where the gender bias is more evident (like ­chemistry, Technical Assistants 39 persons screening, proteomics, bioinformatics). 20% of total staff In recruiting new scientists, a dedicated effort is made to engage female scientists and foster their career development as much as possible.

Postdoctoral Fellows 40 persons 20% of total staff

PhD Students 52 persons 27% of total staff

Facts 121 122 Nationalities at CeMM Expenses in 2013

34 different nationalities are represented at CeMM.

Finland Facility Costs 17% 2

Lithuania 1 Ireland Poland The Netherlands 7 3 2

3 Germany 53% Personnel 25 Czech Republic Consumables 15% 4 3

United Kingdom

Russia

Other Costs 11% Slovakia 1 Investments 4% 2 1 Hungary Austria 96 5 France 2 Switzerland United States

Spain 2 Serbia 4 3 Italy Portugal China South Korea 9 2 Armenia Money Sources in 2013 1 1 1 Algeria 2 1 1 Croatia Lebanon 1 1 4 Greece Pakistan Singapore Colombia Cyprus 1 1 Brazil India Australia 3 DR Congo 2 1 New Zealand

1

European Union Projects Union European

1,971,192 1,971,192 €

Austrian Science Foundation (FWF)

Publications ¤ 1,599,334

Includes all publications by CeMM staff members from the date of joining 62 the institute.

55

s T ce h n t ir ie e ¤ d ¤ 893,488 Foundation and Companies Grants c g -P 44 S d 5 a f u ,4 r o B t 4 y y e 4 s , F m a 9 u e B 2 n 7 37 d d a 0 s 35 c 0 A 0 33 ,

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14 ¤ 183,069 and the TechnologyVienna Science Agency and of Technologythe City of Vienna Fund (WWTF) (ZIT) ¤ 30,000 ¤ 29,567 OtherAustrian National Bank ¤ 10,029 Sponsoring 3

Ce — M­—M­— Research Report 2013 2005 2006 2007 2008 2009 2010 2011 2012 2013 Facts 123 124 Testimonials

It has been a long and so-far successful tradition to invite notable people to give us their take on CeMM’s Dr. Johannes Hahn Dr. Beatrix Karl Peter Kogler philosophies and performance, which we include in Commissioner of the European Union Former Austria’s Federal Minister of Science and Research Artist our annual research reports. These people are both advisors and supporters of CeMM, and have included holders of prominent positions in government and ­academia, accomplished artists, and comedians and a sporting World Champion.

The photographs of those who have imparted their ­testimonials in the past are presented in the following pages. This year, the new contributions can be found Prof. Dr. Karlheinz Töchterle Dr. Michael Häupl collected in the “life” part of the research report. Former Austria’s Federal Minister of Science and Research Mayor of the City of Vienna We believe that we can learn from their opinions, and ­benefit from their approval and encouragement.

Niki Lauda Brigitte Kowanz Prof. Dr. Georg Stingl Former President of the Section F1 World Champion and Airline Founder Artist for Natural Sciences of the ÖAW

Prof. Dr. Wolfgang Schütz Dr. Andreas Mailath-Pokorny Rector, Medical University of Vienna City Councilor for Culture and Science, Vienna

Mag.a Monika Kircher-Kohl Former Chief Executive Prof. Dr. Max L. Birnstiel Founding Director of Mag.ª Brigitte Ederer Officer, Infineon Technologies Austria AG the ­Research Institute of Molecular Pathology (IMP) Member of the Executive Board of Siemens AG ÖAW Austrian Academy of Sciences MUV Medical University of Vienna AKH Vienna General Hospital

Prof. Dr. Bernhard Felderer Former Director, Prof. Dr. Helga Nowotny Ph.D. Founding member Prof. Dr. Helmut Denk Prof. Dr. Reinhard Krepler Eva Schlegel Institute for Advanced Studies, Vienna and former President, European Research Council Former President of the Austrian Academy of Sciences Director of the Vienna General Hospital Artist

Prof. Dr. Ursula Schmidt-Erfurt Head of the ­Department Prof. Dr. Hans Tuppy Chair of the Board of the ­University Prof. Dr. Harald zur Hausen Robert Palfrader Austrian comedian in his most famous Prof. Dr. Bernd Binder † Department of Ophthalmology and Optometrics at the MUV/AKH of Natural ­Resources and Applied Life Sciences Vienna Winner of the Nobel Prize for Medicine 2008 social satire role as the (fictitious) Austrian Emperor of Vascular ­Biology and Thrombosis Research, MUV

Dr. Heinz Fischer Martin Walde Dorothee Golz Dr. Hannes Androsch Chair, Austrian Council for Dr. Johanna Rachinger Director General of the Austrian President of the Austrian Republic Artist Artist ­Research and Technology Development Senator, ÖAW National Library, Member of the Senate of the ÖAW

Prof. Dr. Josef Penninger Scientific Director, Dr. Benedikt and Beatrice Spiegelfeld Prof. Dr. Helmut Gadner Former Director, Mag.ª Barbara Prammer President of the Austrian Prof. Dr. Christoph Zielinski Chairman, Thomas Feuerstein Institute of Molecular Biotechnology (IMBA) Sponsors of the Constantin Spiegelfeld Lecture St. Anna Children’s Cancer Research Institute National Council, Member of the Senate of the ÖAW Department of Medicine I and Cancer Center, AKH/MUV Artist

Esther Stocker Prof. Dr. Peter Schuster Prof. Dr. Arnold Pollak Head of the Department of Prof. Dr. Christine Mannhalter Molecular Diagnostics Walking Chair Artist Former President of the Austrian Academy of Sciences Pediatrics and Adolescent Medicine, MUV MUV, Vice President of the Austrian Science Fund Artists Iris Ranzinger Herwig Tachezi Meinhard Rauchensteiner Akinori Takaoka Acknowledgements Mehrnoosh Rayner Klaus Taschwer Gerda Redl Stefan Thurner Michael Rehli Karlheinz Töchterle Caetano Reis e Sousa Michael Trauner Ingrid Riedel-Taschner Hans Tuppy Yazan Abbas Hubert-Christian Ehalt Harald Isemann Andreas Mailath-Pokorny Uwe Rix and Lily Remsing Rix Alfonso Valencia Ruedi Aebersold Wilfried Ellmeier Steve Jackson Matthias Mann Maria Grazia Roncarolo Peter Valent Adriano Aguzzi Heinz Engl Ulrich Jäger Christine Mannhalter Artur Rosenauer Eelco van Anken Genevieve Almouzni Bernhard Felderer Sigrid Jalkotzy-Deger Giorgio and Loriana Marrapodi Nadia Rosenthal Alexander van der Bellen Michael Alram Ulrike Felt Martin Janku Thomas Marlovits Walter Rosenthal Franziskus von Kerssenbrock Gustav Ammerer Thomas Feuerstein Susan le Jeune Marjori Matzke Stefan Rothleitner Henri van Luenen Hannes Androsch Mathias Fichtinger d’Allegeershecque Brigitte Mazohl Philippe Sansonetti Menno C. van Zelm Johannes Angerer Margit Fischer Stefan Joham Karl Mechtler Michael Sazel Markku Varjosalo Stylianos Antonarakis Richard Flavell Kai Johnsson Richard R. Meehan Gerhard Schadler Marc Vidal Roland Arnold Elisabeth Förster-Waldl Ulrich Jordis Jürgen Meier Reinhold Schäfer Erwin Wagner Christian Arthaber Jonathan Frampton Manfred Jung Michael Metzeltin Charlotte Schelander Oswald Wagner Markus Aspelmeyer Ronald Frank Johannes Kasal Reinhold Mitterlehner Andreas Schibany (†) Stephan Wagner Charles Auffray Andre Franke Olli Kallioniemi Alois Mosbacher Oliver Schilling Michael Wakelam Andrea Ballabio Michael and Margarita Dontscho Kerjaschki Markus Müller Eva Schlegel Martin Walde Ralf Bartenschläger Freissmuth Markus Kiess Mathias Müller Ursula Schmidt-Erfurth Xiang Wang Petr Bartunek Helmut Gadner Melitta Kimbacher Bushan Nagar Helmut Schneider Graham Warren Angela Bauch Susan Gasser Stefan Knapp Alexander Nagler Stuart Schreiber Herbert Watzke Hemma Bauer Anne-Claude Gavin Jürgen Knoblich Angel Nebreda Wolfgang Schütz Susanne Weigelin-Schwiedrzik Christoph Baumann Tamar Geiger Christian Köberl Dario Neri Hans Peter Schwarz Robert A. Weinberg Marianne Baumgart Frederic Geissmann Reinhart Kögerler Claus Nerlov Christian Seidl Barbara Weitgruber Stephan Beck Francesco Gervasio Peter Kogler Johan Neyts Luis Serrano Markus Wenk Axel Behrens Fabiola Gianotti Walter Kolch Christian Noe Veronika Sexl Georg Wick Christian Behrends Andre Gingrich Zenita Komad Magnus Nordborg Maria Sibilia Georg Winter Yinon Ben-Neriah Heinz Gisslinger Ernst M. Kopper Helga Nowotny Angela Siegling Susanne Wischnewski Waldemar Benedict Wolfgang Gleissner Joanne Kotz Fritz Ohler Jörg Simonitsch Hans Wojta Paolo Bernardi Christoph Gnant Heinrich Kovar Udo Oppermann Roberto Sitia Frank Wurm Gabrielle Bertier Dorothee Golz Peter Kowalski Katharina and Primus Uwe Sleytr Manfred Würthner Andreas Bichl Herbert Gottweis (†) Brigitte Kowanz Österreicher Josef Smolen Yosef Yarden Max and Margaret Birnstiel Elisabeth Grabenweger Christoph Kratky Peter Pakesch Andreas Sommer Rudolf Zechner Martin and Lucrezia Böhm Tony Green Norbert Kraut Renate Panzer Natalie de Souza Anton Zeilinger Stefan Böhm Claudia Greiner Michael Krebs William E. Paul Barbara Speicher Christoph Zielinski Bernd Bodenmiller James D. Griffin Reinhard Krepler Tony Pawson (†) Michael Speicher Rolf M. Zinkernagel James Bradner Christoph Grissemann Daniel Kroh Israel Pecht Michael Stampfer Johannes Zuber Georg Brasseur Bernhard Groehs Franco Laccone Hubert Pehamberger Louis Staudt Harald zur Hausen Rolf Breinbauer Matthias Gstaiger Werner Lanthaler Pier Giuseppe Pelicci Laura Steenpass Julius Brennecke Karin Gutierrez-Lobos Martin Larsen Josef Penninger Dirk Stermann Soren Brunak Barbara Haberl Hans Lassmann Jan-Michael Peters Manfred Stelzer Judith Brunner Johannes Hahn Klaus Lechner Fidel Peugeot Georg Stingl Günther Burkert Brigitte Haidl Kriso Leinfellner Elmar Pichl Esther Stocker Jo Bury Bernhard Hain Hans Leitner Andreas Pichlmair Florian and Annick Stockert Meinrad and Irene Busslinger Sonja Hammerschmid Stefanie Lichtwitz Helen Pickersgill Hannes Stockinger Jakob Calice Oliver Hantschel David Livingston Karl Emilio Pircher Erich Streissler John Castle Peter Harold Robert Loewe Hidde Ploegh Carl-Wolfgang Stubenberg Riki Cheevers Michael Häupl Jiri Lukas Walter Pohl Marius Sudol Gianni Cesareni Eric Haura Wolfgang Lutz Arnold Pollak Andrea Superti-Furga Hans Clevers Albert Heck Jeff Porter Stefanie Superti-Furga Thomas Decker Peter Heil Barbara Prainsack Arnold Suppan Helmut Denk Claudia Heilmann-Sennhenn Barbara Prammer Peter Swetly Markus Dettenhofer Franz Xaver Heinz Christoph Prammer Elke Deuerling Carl-Henrik Heldin Georg and Martina Prantl Maria Manuel Dias Mota Kristian Helin Klaus Pseiner Ross Dickins Thomas Helleday Barry Dickson Markus Hengstschläger Ivan Dikic Adriano Henney Christiane Druml Matthias Hentze Stephanie Dumon Thomas Henzinger Franz Herzog Karlheinz Hilber Denis Hochstrasser Herbert Hollaus Andrew Hopkins Jonathan Howard Lukas Huber

Ce — M­—M­— Research Report 2013 Facts 129 130 How to Reach CeMM

CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences Lazarettgasse 14, AKH BT 25.3 Main Entrance 3rd Floor 1090 Vienna, Austria

Tel +43-1/40160-70 011 Austria [email protected] www.cemm.at

Vienna

l rte AKH-Campus Gü r ge n ri h ä W Green Tower Red Tower Main Entrance

South Entrance Spitalgasse CeMM

Borschkegasse

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4,2426 5,0990 5,2915 6,6332 5,2915 5,6569 5,8310 5,8310 6 4,7958 4,5826 4,5826 5,2915 5,0990 4 4,8990 4,6904 6,3246 5,2915 6 6 6,1644 5,9161 5,7446 4,3589 5,0990 5,0990 5,2915 4,6904 4,2426 4,4721 4,4721 4,8990 5,0990 5,8310 6 4,7958 4,8990 5,2915 4,8990 4,6904 4,4721 4,7958 4,3589 4,5826 Copyrights If you want information about Research Report 2007 4,8990 4,2426 0 4,4721 5,0990 5,0990 4 4,2426 4,2426 4,4721 2 3,1623 4 4,8990 5,0990 5,8310 6 5,2915 5,8310 5,8310 4,8990 5,2915 5,6569 5,2915 4,6904 3,7417 4,4721 4,2426 4 3,1623 3,7417 4,4721 4,6904 4 5,4772 5,4772 5,6569 4,6904 4,8990 5,4772 5,6569 5,2915 4,8990 4,6904 4 5,0990 4,8990 4,2426 4,8990 5,0990 4,4721 4© CeMM3,7417 Research4,6904 Center5,0990 for 4,6904 6 what 6,6332CeMM worked5,6569 on4,8990 5,2915 6 5,4772 4,5826 4,7958 4,5826 5,8310 5,6569 4,8990 4 4,8990 6 5,8310 5,4772 5,6569 5,8310 5,5678 5,5678 5,3852 5,4772 5,2915 5,2915 4,2426 4 5,4772 4,2426 5,4772 5,0990 5,6569 5,8310 4,5826 5,0990 5,2915 4,6904 5,4772 5,2915 4,7958 4,7958 4,7958 5,0990 4,2426 4,4721 0 5,0990 5,0990 3,1623 4,4721 4,4721 5,0990 4,8990 4,8990 4,4721 4,4721 2,8284 5,8310 6 5,4772 5,8310 5,8310 4,2426 4,8990 5,4772 4,6904 4,6904 4,8990 5,2915 5,4772 5,6569 5,0990 5,2915 4,6904 4,6904 4,6904 5,4772 5,4772 5,6569 3,7417 4,8990 4,8990 5,2915 4,8990 5,0990 4,8990 5,0990 6 5,8310 5,0990 4,6904 5,2915 4,8990 5,4772 5,4772 5,4772 4,6904 3,7417 5,0990 6,7823 6 4,6904 4,8990 5,6569 5,4772 5 5,1962 4,7958 6,1644 5,8310 4,8990 5,6569 5,6569 5,6569 5,6569 5,6569 5,2915 5,4772 5,5678 6,2450 5,1962 6 6,1644 6,1644 5,4772 5,2915 5,6569 5,2915 5,8310 5,8310 5,2915 5,4772 5,5678 6 6,1644 5,6569 5,8310 5,6569 5,7446 5,1962 5 Molecular Medicine of the in 2007–2012 you can order our Research Report 2010 6 5,4772 5,0990 5,0990 0 2,8284 4,4721 5,4772 5,8310 6 5,4772 5,2915 5,0990 5,4772 5,6569 4,2426 4 4,4721 4 4 4,6904 5,2915 5,6569 5,0990 5,8310 5,2915 5,6569 5,8310 6 5,6569 5,6569 5,8310 5,6569 5,8310 4,4721 4,4721 3,7417 5,2915 4,6904 5,0990 5,4772 5,0990 6,1644 6 5,4772 6,3246 6,1644 5,4772 5,8310 5,8310 5,6569 5,8310 5,8310 6,4807 6 5,4772 4,2426 4,8990 5,6569 4,6904 4,8990 5,2915 4,8990 5,3852 6,0828 5,3852 6,9282 6,6332 5,8310 6 6,1644 5,6569 6,1644 5,6569 5,0990 5,6569 5,5678 6,5574 6,4031 5,6569 6 6 5,0990 5,0990 6 5,0990 6,3246 5,4772 5,0990 5,0990 5,1962 5,8310 6 5,2915 6,1644 6 5,3852 6,0828 5,7446 ­Austrian Academy of Sciences previous Research Reports: 6,1644 5,6569 5,0990 5,0990 2,8284 0 4,6904 5,6569 5,8310 6,1644 5,4772 5,4772 5,2915 5,6569 5,6569 3,4641 3,4641 4,8990 3,4641 3,4641 4,8990 5,2915 5,8310 5,2915 6 5,4772 5,8310 6 6,1644 5,6569 5,8310 6 5,8310 6 4,2426 4,2426 4,6904 5,2915 4,8990 5,2915 5,6569 4,8990 6,3246 6,1644 5,6569 6,4807 6,3246 5,6569 6 6 5,6569 6 6 6,6332 6,1644 5,4772 5,0990 5,4772 5,8310 4,8990 4,8990 5,2915 5,2915 5,5678 6,2450 5,5678 7,0711 6,7823 6 6,1644 6,3246 5,8310 6,3246 5,6569 5,2915 5,8310 5,7446 6,7082 6,5574 5,8310 6,1644 6,1644 5,4772 5,2915 6,1644 5,2915 6,4807 5,8310 5,0990 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5,2915 5,6569 5,0990 4,2426 4,2426 4 4,8990 5,0990 4 4 4,4721 4,6904 4,47211090 Vienna,4,4721 Austria4,6904 4,4721 4,8990 5,2915Eva Schweng6,6332 5,2915 5,0990 5,8310 5,8310 5,4772 4,7958 5 4,7958 5,6569 5,6569 4,2426 4,6904 4,8990 6,3246 5,4772 5,4772 6 6,1644 5,3852 5,9161 4,5826 5,2915 5,0990 5,0990 4,4721 4,6904 4,8990 4,2426 5,0990 5,2915 5,8310 5,6569 4,3589 5,2915 5,4772 4,8990 5,0990 5,2915 5,1962 4,7958 4,5826 5,0990 4,2426 4,2426 4,4721 5,8310 5,8310 4,8990 2,4495 0 4 3,7417 3,4641 4 5,0990 4,2426 5,8310 6 5,0990 5,8310 5,8310 4,8990 5,2915 5,6569 5,2915 4,4721 4,0000 5,0990 4,8990 5,2915 4,2426 4,4721 3,7417 5,4772 4,2426 5,4772 5,4772 5,8310 4,8990 5,0990 5,6569 6 5,2915 4,6904 4,6904 4,4721 5,2915 5,4772 4,4721 4,2426 4,4721 4,6904 4,6904www.cemm.at4,6904 4,2426 4,4721 4,6904 5,4772CeMM6,9282 Research5,4772 Center5,2915 for Molecular­ 5,8310 6,1644 5,8310 5,1962 5 5,1962 5,4772 5,6569 4,2426 4,8990 4,4721 6,6332 5,2915 5,8310 6,3246 6,4807 5,9161 6,2450 4,7958 5,6569 5,4772 5,4772 4,6904 4,8990 4,8990 4,2426 4,8990 5,6569 6,1644 6 5 5,6569 5,8310 5,4772 4,6904 4,8990 5,5678 4,7958 5,0000 4,4721 4,4721 4,4721 5,0990 6 6,1644 4,8990 4 4 0 4 3,7417 4,2426 5,0990 4,8990 6,1644 6 5,6569 5,8310 5,8310 4,8990 5,8310 5,8310 5,2915 4,8990 4,4721 4,4721 3,4641 4,2426 4,4721 4,4721 4,2426 5,0990 4 5,8310 5,8310 6 5,2915 5,2915 5,6569 6 5,8310 5,2915 5,0990 4,4721 4,8990 4,8990 4,4721 4,4721 4,6904 4,4721 3,4641 4,6904 4,6904 4,6904 5,2915 5,8310Medicine7,0711 of the5,6569 5,6569 6,3246 6,3246 6 5,1962 4,5826 5,1962 4,6904 4,8990 4,2426 4,6904 4,6904 6,7823 5,8310 6,1644 6,4807 6,4807 6,0828 6,2450 5 4,8990 4,8990 5,0990 5,0990 5,0990 3,7417 4,8990 5,4772 5,8310 6,4807 6,3246 5,1962 5,0990 5,4772 5,6569 5,0990 5,2915 5,7446 4,7958 5,3852 5,2915 4,6904 2 4,8990 5,4772 5,4772 4,4721 3,7417 3,7417 4 0 2,4495 3,4641 4,4721 4,6904 5,4772 5,6569 4,8990 5,4772 5,4772 4,4721 4,8990 5,2915 4,8990 4,8990 3,4641 4,6904 4 4,2426 2,8284 3,4641 4,2426 4,4721 4,2426 5,2915 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4,4721 4,5826 5,0990 5,4772 5,0990 5,0990 5,2915 5,1962 5,5678 5,5678 2007 2010 6,4807 5,4772 5,2915 4,8990 5,2915 5,2915 4,4721 5,2915 5,2915 5,8310 4,8990 4,8990 4,6904 4,4721 4,6904 5,0990 5,2915 4,2426 5,0990 5,2915 4,4721 0 5,6569 4,8990 6 4,6904 5,8310 5,8310 6 5,0990 5,0990 5,8310 4,8990 6,1644 4,8990 4,8990 4,8990 4,0000 4,6904 5,0990 5,2915 4,6904 6,4807 6,3246 5,4772 5,8310 6 5,2915 5,8310 6,3246 4,8990 5,4772Helen Pickersgill,4,8990 5,8310 Ph.D.5,4772 4 5,4772 5,8310 6 4,2426 4,4721 5,0990 5,4772 5,7446 6,2450 5,3852 6,3246 6,4807 5,6569 5,6569 6,3246 5,4772 6,3246 5,4772 5,0990 6,1644 5,5678 6,7082 6,0828 6 6,1644 6,1644 5,2915 5,4772 6,1644 5,2915 6,4807 6,3246 5,2915 5,0990 5,7446 6,3246 6,4807 6,1644 6,1644 6,3246 6,0828 6,2450 6,0828 6,4807 6 5,6569 5,4772 5,6569 5,8310 4,6904 5,2915 5,6569 5,8310 5,2915 5,0990 5,0990 4,8990 5,2915 5,8310 5,8310 5,8310 5,6569 5,6569 3,7417 5,6569 0 3,4641 6 5,2915 6 5,8310 6,3246 5,6569 5,6569 5,8310 5,2915 6,1644 6 6 6,1644 5,0990 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5,2915 4,4721 5,6569 4,8990 5,0990 4,8990 5 5,4772 5,8310 5,4772 5,4772 5,6569 5,5678 5,9161 5,9161 4,2426 3,1623 4,6904 4,6904 5,8310 6 4,8990 4,2426 4,4721 4,8990 4,8990 4,6904 4,6904 5,2915 5,0990 6,1644 6,1644 6 6 6,3246 5,4772 6 6 5,8310 0 4 4,4721 5,0990 4,8990 4,4721 4,4721 4,2426 5,2915 4,2426 5,8310 5,8310 5,6569 5,0990 5,0990 5,4772 6 5,6569 4,2426 3,7417 4,2426 5,4772 5,2915 4,4721 4,6904 5,0990 5,0990 4,8990Editorial4,8990 Team 4,6904 5,0990 5,2915 5,4772 7,0711 5,6569 5,8310 6 6,1644 6,1644 4,5826 4,5826 4,5826 5,8310 5,6569 4,4721 5,0990 5,0990 6,3246 5,6569 6,1644 6 6,4807 6,0828 5,7446 4,3589 5,6569 5,6569 5,6569 4,8990 4,6904 5,0990 4,6904 5,2915 5,2915 6 6,1644 5 5,4772 5,6569 5,0990 5,2915 5,0990 5,1962 5 5 5,0990 4 3,7417 4,8990 5,2915 5,4772 4,2426 3,7417 4 4,4721 3,4641 3,1623 3,4641 4,2426 4,8990 5,2915 5,2915 4,8990 5,0990 5,4772 4,4721 4,6904 5,2915 4,8990 4 0 3,7417 4 4 2,8284 2,4495 4 4,2426 4,4721 4,8990 4,8990 4,6904 4 4 4,4721 5,0990 4,6904 5,0990 4,8990 3,7417 4,4721 4,6904 3,1623 4,4721 4,8990 3,7417 3,4641Riki Chevers3,1623 4,4721 4,8990 4,2426 5,2915 6,3246 4,8990 4,6904 5,2915 5,2915 5,2915 4,5826 5,1962 4,5826 5,0990 5,6569 4 3,7417 4,6904 6 5,2915 5,0990 5,6569 6 5,1962 5,7446 5 4,6904 4,6904 4,6904 3,1623 3,4641 4,6904 3,1623 4,8990 4,6904 5,4772 5,2915 3,8730 4,8990 5,0990 4,4721 4,6904 4,8990 4,5826 5 5 4 4,4721 4,4721 5,2915 5,6569 5,8310 4,6904 4,6904 5,0990 4,4721 4,6904 4,4721 4,2426 5,0990 5,2915 6 5,6569 5,8310 5,8310 6,1644 5,2915 5,8310 6 5,6569 4,4721 3,7417 0 3,1623 3,7417 3,7417 4 4,2426 5,0990 4,4721 5,6569 5,6569 5,0990 4,8990 4,8990 5,2915 5,8310 5,4772 5,0990 4,8990 4,6904 3,7417 3,4641 3,7417 5,2915 5,2915 4,2426 4Marc Brehme4,4721 5,0990 5,2915 5,2915 6 6,9282 5,8310 5,6569 5,8310 6 6 4,5826 5,5678 5 4,8990 4,6904 4,4721 4,6904 5,2915 6,3246 6,1644 6 6 6 5,9161 5,7446 5,3852 4,4721 4,4721 4,4721 4,6904 4,4721 4,6904 4,4721 5,8310 5,0990 5,8310 6 4,3589 4,2426 4 4,8990 5,6569 5,4772 4,5826 5,3852 5 3,7417 5,0990 4,2426 5,4772 5,8310 6 4,8990 4,4721 4,8990 3,4641 4 3,4641 4,2426 5,2915 5,0990 6,1644 5,8310 5,6569 6 6 5,0990 5,8310 5,8310 5,4772 5,0990 4 3,1623 0 3,7417 3,4641 4 4,2426 4,8990 4,2426 5,4772 5,4772 5,2915 4,8990 4,6904 5,4772 5,8310 5,4772 5,2915 5,0990 4,4721 4 4,4721 4 5,0990 5,0990 4,2426 3,4641 4,4721 4,8990 5,0990 5,2915 6,1644 6,9282 6 5,2915 6,1644 6,1644 5,8310 4,7958 5,3852 5,1962 4,8990 5,2915 4,6904 4,4721 5,0990 6,6332 6,3246 6 6,3246 6,1644 5,9161 5,9161 5,1962 4,8990 4,8990 4,8990 4,8990 5,0990 4,6904 4,6904 6 5,6569 6,1644 6,1644 4,5826 5,0990 4,6904 5,4772 5,8310 6 5,1962 5,5678 5,1962 4,8990 4,8990 4 5,6569 6 6,1644 5,0990 5,0990 5,2915 4,2426 4,2426 4,2426 4,8990 5,2915 6 6,3246 6,3246 6 6,1644 6,4807 5,6569 6 6,3246 6 4,8990 4 3,7417 3,7417 0 4 4 5,0990 4,8990 4,6904 6 6 5,8310 5,2915 5,2915 5,6569 6 5,8310 5,6569 5,4772 4,8990 4,6904 4,4721 4,6904 5,6569 5,8310 4 3,1623 4,2426 5,0990 5,8310 5,4772 6,3246 7,0711 6 5,8310 6 6,3246 6,1644 5,3852 5,5678 5,3852 5,2915 5,4772 5,2915 3,1623 5,2915 6,4807 6,1644 6,1644 6,1644 6,4807 6,0828 6,2450 6,0828 5,0990 4,8990 4,8990 4,6904 4,4721 4,8990 4,6904 5,8310 5,4772 6 6,1644 5 4,6904 4,8990 5,0990 5,8310 5,6569 5,1962 5,5678 5,5678 Art Direction and Design 5,0990 4,4721 3,1623 5,0990 5,6569 5,6569 4,6904 4,2426 4,2426 4,4721 2,8284 3,1623 4 4,6904 4,6904 5,4772 5,2915 5,2915 5,4772 5,8310 4,8990 5,0990 5,6569 5,2915 4,4721 2,8284 3,7417 3,4641 4 0 2,8284 4 4,2426 4 5,2915 5,2915 4,6904 4,2426 4,4721 4,8990 5,4772 4,8990 5,0990 4,8990 4,2426 4,4721 4,6904 3,1623 4,8990 4,8990 4 3,4641 3,4641 4 4,8990 4,4721 5,6569 6,6332 5,2915 4,8990 5,4772 5,6569 5,6569 4,5826 5,1962 5 5,2915 5,6569 4 3,7417 4,2426 6,3246 5,6569 5,2915 6 6 5,5678 5,7446 5 5,0990 5,0990 5,0990 4 4,2426 5,0990 3,7417 5,2915 5,0990 5,8310 5,6569 3,8730 5,2915 5,0990 4,8990 5,0990 5,2915 4,5826 5,3852 5 5,4772 4,4721 3,7417 5,2915 5,6569 5,8310 4,6904 4,2426 4,4721 4,4721 3,4641 3,1623 3,4641 4,4721 5,2915 5,4772 5,6569 5,2915 5,4772 5,6569 4,8990 5,0990 5,6569 5,2915 4,4721 2,4495 4,0000 4 4 2,8284 0 4,2426 4 4,4721 5,2915 5,2915 5,0990 4,2426 4,4721 4,8990 5,4772 5,0990 5,4772 5,2915 4,2426 4,8990 5,0990 3,7417 4,4721 4,8990 4,2426 3,4641Lichtwitz2,8284 Leinfellner4,4721 5,2915 4,6904 5,2915 6,6332 5,2915 5,0990 5,6569 5,6569 5,6569 5,0000 5,1962 5 5,4772 6 4,4721 3,7417 4,6904 6,3246 5,6569 5,4772 6 6,1644 5,5678 5,9161 5,1962 5,0990 5,0990 5,0990 3,7417 4 5,0990 3,7417 5,2915 5,0990 5,8310 5,6569 4,3589 5,2915 5,4772 4,6904 5,0990 5,2915 5 5 5 4,6904 4,2426 4,4721 4,6904 5,8310 6 4,8990 3,7417 3,7417 4,2426 4,2426 4,2426 4 5,0990 4,2426 6,1644 5,8310 5,6569 6 6 5,0990 5,8310 5,8310 5,4772 4,2426 4 4,2426 4,2426 5,0990 4 4,2426 0 5,0990 3,1623 5,4772 5,4772 5,2915 4,8990 4,8990 5,4772 5,6569 5,4772 4,2426 4 4,2426 4,8990 5,0990 4 4,2426 3,1623 5,0990 4,8990visuelle4,4721 Kultur 4KG 3,7417 5,0990 5,4772 6,7823 5,6569 5,4772 6,1644 6,1644 5,6569 4,7958 5 5,1962 5,0990 5,0990 3,7417 4,8990 4,2426 6,4807 5,4772 6 6,1644 6 5,7446 5,7446 4,3589 5,6569 5,4772 5,4772 4,6904 4,8990 4,8990 4,6904 5,0990 5,6569 6,1644 6 4,3589 5,6569 5,4772 5,2915 5,0990 5,2915 5 4,5826 4,3589 6,1644 5,0990 4,6904 4,6904 5,6569 5,8310 3,4641 5,0990 5,4772 5,0990 4,4721 4,4721 4 2 4,6904 5,2915 5,4772 5,4772 5,2915 5,2915 3,7417 4,8990 5,2915 4,2426 5,2915 4,2426 5,0990 4,8990 4,8990 4,2426 4,0000 5,0990 0 4,8990 5,2915 5,2915 5,0990 3,1623 4,4721 3,7417 4,2426 4,6904 6 5,8310 4,6904 5,4772 5,4772 4,4721 5,0990 5,4772 4,6904 4,4721Kriso Leinfellner4,4721 5,2915 5,0990 4,2426 5,4772 6,4807 5,8310 4,6904 5,2915 5,2915 5,0990 5,1962 5,5678 5 6 6,1644 4,8990 4,6904 5,2915 5,6569 5,4772 5,2915 5,2915 4,8990 5 5,9161 5,5678 5,4772 5,4772 5,6569 4,8990 4,8990 5,6569 4,8990 5,8310 5,8310 5,0990 4,8990 5 5,6569 6 5,0990 5,8310 6 5,5678 5,5678 5,5678 4,4721 4 4 4,6904 5,8310 6 4,6904 4,2426 4,2426 4 4,2426 4,2426 4,6904 5,2915 4,6904 6,4807 6 6 6,1644 6,1644 5,2915 6,1644 6,1644 5,6569 4,2426 4,4721 4,4721 4,2426 4,6904 4 4,4721 3,1623 4,8990 0 5,8310 5,8310 5,6569 5,2915 5,2915 5,6569 5,8310 5,8310 4,2426 4 4,4721 5,2915 4,8990 4,2426 4,4721 4 5,4772 4,6904Stefanie4,6904 Lichtwitz3,7417 3,4641 5,4772 5,8310 7,0711 5,8310 5,8310 6,1644 6,4807 6 4,5826 4,3589 5 5,2915 4,8990 4 4,8990 3,7417 6,4807 5,6569 6,3246 6,1644 5,8310 6,0828 5,5678 4,5826 5,8310 5,6569 5,8310 5,0990 4,6904 5,0990 5,0990 5,2915 5,6569 6,1644 6,3246 4,7958 5,4772 5,4772 5,2915 5,2915 5,0990 5 4,3589 4,3589 6,3246 5,6569 5,4772 5,4772 4,4721 4,2426 4,8990 5,0990 5,4772 5,8310 5,2915 5,0990 4,8990 5,2915 5,4772 4,2426 4,4721 4,2426 4 4 5,0990 4,8990 6,0000 5,4772 5,8310 4,8990 5,6569 5,4772 6 5,2915 5,2915 5,4772 5,2915 5,8310 0 0 3,7417 4,8990 5,0990 5,4772 5,8310 5,2915 6,1644 6,1644 5,2915 5,8310 6 5,2915 5,6569 6,1644 5,4772 5,6569Martha 5,4772Riessland6,1644 5,6569 5,2915 4,8990 5,6569 6,1644 5,0990 5,8310 5,4772 5,6569 5,5678 5,9161 5,1962 6,4807 6,4807 5,6569 5,8310 6,4807 6,3246 6,6332 6,1644 6 6,4807 6,0828 6,4031 6,0828 5,8310 5,8310 5,8310 5,6569 5,8310 6 5,4772 6,6332 6,3246 5,8310 5,6569 5,7446 6,1644 6,3246 6,1644 6,1644 6,3246 5,9161 6,0828 5,9161 6,3246 5,6569 5,4772 5,4772 4,4721 4,2426 4,8990 5,0990 5,4772 5,8310 5,2915 5,0990 4,8990 5,2915 5,4772 4,2426 4,4721 4,2426 4 4 5,0990 4,8990 6 5,4772 5,8310 4,8990 5,6569 5,4772 6 5,2915 5,2915 5,4772 5,2915 5,8310 0 0 3,7417 4,8990 5,0990 5,4772 5,8310 5,2915 6,1644 6,1644 5,2915 5,8310 6 5,2915 5,6569 6,1644 5,4772 5,6569 5,4772 6,1644 5,6569 5,2915 4,8990 5,6569 6,1644 5,0990 5,8310 5,4772 5,6569 5,5678 5,9161 5,1962 6,4807 6,4807 5,6569 5,8310 6,4807 6,3246 6,6332 6,1644 6 6,4807 6,0828 6,4031 6,0828 5,8310 5,8310 5,8310 5,6569 5,8310 6 5,4772 6,6332 6,3246 5,8310 5,6569 5,7446 6,1644 6,3246 6,1644 6,1644 6,3246 5,9161 6,0828 5,9161 6,1644 5,4772 5,6569 5,6569 3,7417 4,6904 5,0990 5,4772 5,8310 6 5,4772 5,2915 5,0990 5,0990 5,2915 4,6904 4 4,2426 4,4721 4,8990 5,2915 4,8990 6,1644 5,6569 5,6569 4,6904 5,0990 5,2915 5,8310 4,6904 5,0990 5,2915 5,0990 5,6569 3,7417 3,7417 0 4,8990 5,0990 5,2915 5,8310 5,4772 6,1644 6 5,4772 5,4772 5,6569 4,6904 5,8310 6 5,2915 5,4772Photography,5,2915 Illustration5,6569 5,4772 5,2915 3,7417 5,0990 6 5,2915 5,8310 5,2915 5,6569 5,3852 6,0828 5,3852 6 6,1644 5,0990 5,6569 6,0000 6,3246 6,4807 6,1644 6 6,3246 6,0828 6,2450 5,9161 5,6569 5,8310 5,8310 5,2915 5,6569 5,8310 5,2915 6,4807 6 5,8310 5,4772 5,1962 6,1644 6 6 6 6,1644 5,3852 6,2450 5,5678 5,8310 5,0990 4,6904 3,7417 5,2915 5,2915 3,4641 4,6904 4,8990 5,2915 4,4721 4,4721 3,4641 3,1623 3,7417 4,8990 5,4772 5,0990 5,2915 5,0990 3,7417 4,0000 5,0990 4,2426 5,0990 4 4,8990 4,8990 5,2915 4,2426 4,2426 4,8990 3,1623 5,2915 4,8990 4,8990 4,8990 0 3,7417 4 4,2426 3,7417 5,8310 5,6569 4,6904 5,4772 5,6569 4,4721 4,8990 5,4772 4,2426 4,8990Lukas Beck4,8990 (pp.5,6569 21, 25) 5,0990 2,8284 5,2915 6,1644 5,8310 4,2426 4,4721 5,0990 5,0990 5 5,7446 4,7958 6,1644 6 4,8990 5,0990 5,8310 5,2915 5,8310 4,8990 4,8990 5,0990 4,7958 5,9161 5,3852 5,4772 5,6569 5,6569 4,8990 5,0990 5,6569 4,6904 6 5,6569 5,0990 4,8990 5 5,8310 6 5,0990 5,8310 6 5,5678 5,5678 5,3852 5,6569 5,0990 4,8990 4,8990 4,6904 4,8990 4,2426 4,6904 5,0990 5,2915 4,6904 4,2426 4 4,4721 4,8990 4,8990 4,8990 5,2915 4,6904 4,8990 3,7417 4,6904 5,0990 4,2426 5,0990 4 4,8990 4,6904 5,2915 4,4721 4,4721 4,8990 4,4721 5,2915 5,0990 5,0990 5,0990 3,7417 0 3,7417 4 3,4641 5,8310 5,6569 4,6904 5,2915 5,6569 4,4721 5,0990 5,0990 4,4721 4,8990Christoph4,8990 Bock 5,6569(Cover, 5,0990 4,2426 5,6569 5,8310 5,0990 3,7417 4,2426 4,6904 4,8990 5 5,7446 4,7958 6,1644 6 4,8990 5,0990 5,2915 5,0990 5,0990 4,6904 4,4721 5,2915 4,5826 6,2450 5,7446 4,6904 5,0990 5,0990 4,2426 4,4721 5,0990 4,0000 5,4772 5,0990 4,4721 4,4721 4,1231 5,2915 5,2915 4,6904 5,2915 5,4772 4,7958 5,7446 5,5678 6,3246 5,2915 5,4772 4,8990 5,0990 5,2915 3,7417 5,2915 5,6569 5,6569 5,2915 5,0990 4,6904 3,7417 4,8990 5,0990 4,8990 5,6569 4,6904 5,0990 3,1623 5,0990 4,2426 2,8284 5,4772 4,4721 5,2915 5,4772 5,6569 4,8990 4,8990 5,4772 3,7417 5,6569 5,4772 5,4772 5,2915 4 3,7417 0 3,7417 4 6,3246 6,1644 5,0990 5,8310 5,8310 4,6904 5,4772 5,4772 4,8990 5,0990pp. 14-15,5,2915 16-17,6,0000 18-19) 5,4772 4,4721 5,8310 5,8310 4,6904 4,2426 3,7417 4 4,6904 5,3852 6,0828 5,1962 6,3246 6,4807 5,0990 5,4772 5,4772 4,8990 5,0990 4,6904 4,8990 4,8990 4,5826 6,5574 6,0828 4,8990 5,2915 5,4772 4,6904 4,6904 5,2915 4,4721 5,6569 4,8990 4,6904 4,4721 4,5826 5,4772 5,8310 5,0990 5,4772 5,6569 5,1962 6,0828 6,0828 6,6332 5,8310 5,6569 5,2915 5,4772 5,6569 4,2426 5,6569 6 6 5,4772 5,4772 5,0990 4,2426 5,2915 5,6569 5,4772 6,0000 5,2915 5,4772 3,7417 5,2915 4,2426 4,2426 6 5,0990 5,8310 5,8310 6 5,4772 5,4772 5,6569 4,2426 5,8310 5,8310 5,8310 5,8310 4,2426 4 3,7417 0 4,2426 6,4807 6,3246 5,2915 6,1644 6,1644 5,2915 5,8310 5,6569 5,4772 5,6569 5,6569 6,3246 5,6569 4,6904 6,3246 5,4772 5,4772 4,6904 4,8990 5,2915 3,4641 5,7446 6,4031 5,5678 6,6332 6,4807 5,6569 5,8310 5,8310 4,4721 4,2426 3,7417 3,1623 3,7417 3 6,0828 6,4031 5,4772 5,6569 5,8310 5,0990 5,0990 5,8310 5,0990 4,8990 5,4772 4,4721 4,2426 5 5,8310 6,1644 5,4772 5,2915 5,4772 5,1962 6,2450 6,2450 Thomas Fröhle (p. 125) 6,3246 5,6569 5,2915 4,8990 5,0990 4,8990 4,4721 5,0990 5,2915 5,8310 5,0990 5,0990 4,8990 4,6904 4,8990 4,8990 5,0990 5,6569 4,8990 5,0990 4,0000 4,6904 5,0990 4,4721 5,6569 4,6904 5,4772 5,4772 5,8310 4,8990 5,0990 5,4772 4,6904 5,8310 5,2915 5,2915 5,4772 3,7417 3,4641 4,0000 4,2426 0 6 6,1644 5,2915 5,8310 6 5,0990 5,4772 5,6569 5,0990 5,4772 5,4772 6,1644 5,8310 4,2426 6 6,1644 5,6569 4,2426 4,2426 4,2426 4,8990 5,5678 6,2450 5,5678 6,6332 6,4807 5,4772 5,6569 5,8310 5,2915 5,8310 4,4721 4,6904 5,4772 4,5826 6,7082 6,2450 5,2915 5,4772 5,4772 4,8990 5,0990 5,6569 4,6904 6 5,6569 4,4721 4,2426 4,7958 5,6569 5,8310 5,0990 5,8310 6 5,3852 6,2450 6,0828 4,4721 4,6904 4,8990 5,0990 6,1644 6,3246 5,2915 4,2426 4,6904 5,2915 5,0990 5,0990 5,0990 5,8310 5,0990 6,7823 6,4807 6,3246 6,6332 6,6332 5,8310 6,4807 6,4807 6,1644 4,2426 5,0990 5,0990 5,2915 5,6569 5,0990 5,4772 4,2426 6 4,2426 6,1644 6,1644 6,1644 5,8310 5,8310 6,3246 6,4807 6 0 2,4495 4 5,2915 5,0990 4,6904 4,4721 4,6904 5,6569 5,4772Hans Leitner5,2915 (pp.4,8990 76, 107,4,6904 125 5,6569 6 7,2111 6,1644 6 6,3246 6,6332 6,1644 20084,3589 4,7958 4,7958 6 5,6569 4,89902011 5,6569 5,2915 6,7823 6,1644 6,4807 6,4807 6,3246 6,2450 5,3852 4,5826 6,3246 6 6 5,4772 5,2915 5,8310 5,4772 5,8310 6 6,3246 6,4807 5 5,8310 5,6569 5,4772 6 5,8310 5,3852 5 4,5826 4 4,4721 4,6904 4,8990 6 6,1644 5,0990 4,2426 4,6904 5,0990 4,8990 4,8990 4,8990 5,6569 4,8990 6,6332 6,3246 6,1644 6,4807 6,4807 5,6569 6,3246 6,3246 6 3,7417 4,8990 4,8990 5,0990 5,4772 4,8990 5,2915 4 5,8310 4 6,1644 6,1644 6 5,6569 5,6569 6,1644 6,3246 6,1644 2,4495 0 4 5,2915 5,0990 4,4721 4,2426 4,4721 5,4772 5,2915Claudia5,0990 Marcelloni4,6904 (pp.4,4721 68-69) 5,4772 5,8310 7,0711 6 5,8310 6,1644 6,4807 6 4,3589 4,7958 4,7958 5,8310 5,4772 4,6904 5,4772 5,0990 6,6332 6 6,3246 6,3246 6,1644 6,0828 5,3852 4,1231 6,1644 6 6 5,2915 5,0990 5,6569 5,2915 5,6569 5,8310 6,3246 6,4807 4,7958 5,8310 5,6569 5,2915 5,8310 5,6569 5,1962 5 4,1231

4,6904 4,4721 4 5,0990 5,4772 5,6569 4,2426 4 4,4721 4,4721 3,7417 3,7417 3,7417 4,4721 5,0990 5,8310 5,6569 5,2915 5,4772 5,4772 4,4721 5,4772 5,4772 4,8990 4,2426 3,7417 4,6904 4,4721 4,8990 4,2426 4,2426 4,2426 4,6904 4,4721 5,2915 5,2915 5,4772 4,6904 4,6904 5,0990 5,2915 5,2915 4 4 0 4,6904 4,6904 3,4641 4,2426 4,4721 4,4721 4Klaus Pichler4 (pp.4,8990 2, 81,4,4721 82 4,6904 5,6569 6,3246 5,2915 4,8990 5,6569 5,6569 5,0990 3,6056Research Report 2009 4,3589 3,6056 5,6569 5,6569 4,4721 4,4721 5,0990 6,1644 5,6569 5,6569 5,8310 5,8310 5,3852 4,5826 4,3589 5,0990 4,8990 5,0990 4,2426 4,2426 5,0990 4,2426 5,2915 5,2915 5,8310 5,6569 4,3589 5,0990 5,4772 4,8990 5,2915 5,4772 5 4,7958 5 4,8990 4,8990 5,0990 6 6,3246 6,4807 5,4772 4,8990 5,2915 4,8990 4,8990 4,6904 4,8990 5,2915 5,6569 6,3246 6 5,8310 6,1644 6,4807 5,6569 5,8310 6,3246 6 5,4772 4,4721 3,7417 4 4,6904 4,4721 4,8990 4,8990 5,4772 5,2915 5,8310 5,8310 5,4772 5,4772 5,2915 5,8310 6,1644 5,8310 5,2915 5,2915 4,6904 0 2,4495 4 5,4772 5,2915 4,4721 4,2426Luiza Puiu/Europäisches4,2426 4,6904 4,8990 5,4772 6,1644 6,6332 6 5,6569 6,3246 6 6 5,3852 6,0828 5,5678 5,0990 4,6904 4,8990 4,8990 5,4772 6,7823 6,3246 6,3246 6,4807 6,4807 6,0828 6,0828 5,3852 4,4721 4 3,7417 4,8990 5,0990 4,6904 4,8990 6 5,8310 6 6 4,5826 4 3,7417 5,4772 5,8310 6 5 5,7446 5,3852 4,8990 4,4721 4,8990 5,8310 6,1644 6,3246 5,0990 5,0990 5,4772 4,8990 5,0990 5,0990 5,0990 5,2915 5,8310 6,4807 6 6 6,1644 6,4807 5,6569 6 6,4807 6 5,2915 4,6904 3,4641 4,4721 4,4721 4,6904 5,0990 5,0990 5,4772 4,8990 6 6 5,6569 5,6569 5,6569 5,8310 6,1644 6 5,0990 5,0990 4,6904 2,4495 0 4 5,4772 5,2915 4,6904 4,2426Forum 4,4721Alpbach4,8990 (p. 99) 4,8990 5,6569 6,3246 6,7823 6 6 6,1644 6,1644 6,1644 5 5,7446 5,1962 5,0990 4,4721 4,8990 5,0990 5,4772 6,6332 6,3246 6,4807 6,3246 6,1644 6,2450 5,7446 5,3852 4,4721 3,7417 4,2426 5,0990 4,6904 4,6904 5,0990 6 5,6569 6 6,1644 4,7958 3,7417 3,4641 5,2915 5,8310 5,6569 4,7958 5,3852 5,1962 4,8990 4 4,2426 5,0990 5,4772 5,6569 4,2426 4 4,4721 4,4721 4 3,7417 3,7417 4,2426 4,6904 5,4772 4,8990 5,2915 5,0990 5,4772 4,4721 5,2915 5,4772 4,8990 4,4721 3,1623 3,7417 4 4,6904 3,1623 3,7417 4 4,4721 4,2426 5,2915 5,2915 4,6904 4,4721 4,4721 4,6904 5,2915 5,0990 4,6904 4,4721 3,4641 4 4 0 3,7417 4,2426 4 3,4641Dorothee3,7417 Golz 4,2426(pp. 6-7,4,2426 8-9, 4,4721 5,2915 6,3246 4,8990 4,8990 5,4772 5,2915 5,2915 4,1231 4,7958 4,5826 4,6904 4,8990 2,8284 4,2426 4,4721 6,1644 5,4772 5,4772 5,8310 5,6569 5,3852 5 4,5826 4,2426 4,6904 4,8990 4 4 4,6904 3,7417 5,0990 4,8990 5,6569 5,4772 3,6056 4,8990 4,8990 4,6904 4,8990 5,0990 4,3589 4,5826 4,7958 5,2915 4,2426 4,8990 4,6904 5,8310 6 4,6904 4 4,2426 4,4721 4,6904 4,4721 4 4,8990 4,6904 6 6 5,6569 5,8310 5,6569 4,8990 5,8310 6 5,2915 4,6904 4,4721 5,2915 5,0990 5,6569 4,8990 4,4721 4,2426 5,0990 4,4721 5,6569 5,6569 5,8310 4,8990 5,0990 5,4772 5,8310 5,4772 4,4721 4,2426 4,2426 5,4772 5,4772 3,7417 0 4 4,8990 4,690410-11, 12-13)4,8990 4,8990 4,2426 4,8990 4,8990 6,7823 5,2915 5,2915 6 6 5,8310 5 4,5826 5 5,2915 5,2915 3,7417 5,2915 5,0990 6,6332 5,4772 6,1644 6,3246 6,1644 6,0828 5,5678 4,5826 5,0990 5,6569 5,8310 5,0990 5,0990 5,0990 4,8990 5,2915 5,8310 6,3246 6,1644 5,1962 5,8310 6,1644 5,4772 5,2915 5,4772 5,7446 4,1231 4,5826 5,2915 4,6904 5,0990 5,2915 5,8310 6 5,2915 4,4721 4,4721 4,6904 4,8990 4,8990 4,6904 5,2915 4,8990 6 5,6569 6,1644 5,8310 5,6569 4,6904 6,3246 5,6569 5,0990 5,0990 4,8990 5,2915 5,0990 5,8310 4,8990 4,8990 3,1623 5,4772 4 6,1644 6,1644 6 5,4772 5,0990 5,4772 5,6569 5,6569 4,6904 4,4721 4,4721 5,2915 5,2915 4,2426 4 0 5,4772 5,0990Iris Ranzinger5,0990 (pp.4,4721 125-127,4 131) 5,4772 5,4772 6,4807 5,2915 5,0990 6 6 5,4772 5,1962 5,3852 5,5678 5,4772 5,4772 4,2426 5,4772 3,7417 6,3246 5,2915 6 6,1644 5,6569 5,7446 5,9161 4,5826 5,4772 5,0990 5,2915 4,4721 4,4721 4,4721 4,4721 4,6904 5,4772 6,1644 6 4,3589 5,2915 5,2915 5,0990 4,6904 4,8990 5 4,5826 4,5826 5,0990 4,8990 4,4721 4,8990 5,6569 5,6569 4,4721 4,6904 4,6904 4,4721 4,2426 4,2426 4,0000 4,4721 4,8990 5,4772 5,6569 5,2915 5,4772 5,8310 4,6904 4,8990 5,8310 5,0990 5,0990 3,7417 4,2426 4,2426 4 4 4,2426 5,0990 4,6904 5,4772 5,4772 5,4772 5,2915 4,2426 4,4721 4,8990 5,4772 5,0990 5,6569 5,4772 4,4721 4,4721 4,6904 4 4,8990 5,4772 0 2,8284Michael4,2426 Sazel (pp.5,0990 62-63,4,6904 66-67,4 5,4772 6,4807 5,2915 4,6904 5,0990 5,4772 5,6569 4,7958 5,7446 4,5826 5,0990 5,6569 4,6904 4,4721 5,4772 6,1644 5,4772 5,6569 5,8310 6,1644 5,7446 6,2450 5,7446 4,6904 4,8990 4,8990 4,4721 4,6904 4,6904 4,2426 5,6569 5,4772 5,6569 5,4772 4,7958 5,0990 5,2915 5,2915 5,4772 5,6569 5,3852 5,7446 5,5678 4,8990 4,4721 4 5,4772 5,8310 6 4,6904 4,4721 4,6904 3,4641 3,7417 3,4641 4,2426 4,6904 5,4772 5,8310 5,6569 5,4772 5,4772 5,8310 4,8990 5,4772 5,8310 5,2915 4,8990 3,4641 4 3,4641 3,1623 3,4641 3,4641 4,8990 4,4721 4,6904 5,6569 5,6569 5,4772 4,8990 4,8990 5,0990 5,6569 5,4772 5,4772 5,2915 4 4,2426 4,2426 3,4641 4,6904 5,0990 2,8284 070-71, 72-73,3,4641 74-75,4,4721 76-77,5,0990 87, 4,6904 5,6569 6,6332 5,0990 5,0990 5,6569 5,6569 5,6569 5,0000 5,1962 5 4,8990 5,4772 4,4721 3,7417 4,6904 6,4807 5,6569 5,6569 6,1644 6,3246 5,7446 6,0828 5,3852 4,4721 4,4721 4,6904 4,2426 4,2426 4,2426 4 5,2915 5,2915 6 5,8310 4,5826 4,6904 5,0990 5,0990 5,0990 5,2915 5,1962 5,3852 5,5678 5,6569 4,2426 3,7417 5,4772 5,8310 6 4,8990 4,4721 4,6904 4,6904 3,4641 3,4641 4 4,6904 5,4772 5,8310 5,8310 5,0990 5,6569 6 5,0990 4,8990 5,8310 5,4772 4,8990 3,1623 4,4721 4,4721 4,2426 3,4641 2,8284 4,4721 4,4721 4,6904 5,4772 5,4772 5,2915 4,8990 4,8990 5,2915 5,6569 5,4772 5,2915 5,0990 4 4,2426 4,4721 3,7417 4,8990 5,0990 4,2426 3,4641 0 3,7417 4,6904 4,6904 5,6569 6,1644 5,2915 5,0990 5,6569 5,4772 5,4772 5,1962 5,1962 5 5,0990 5,8310 4,6904 3,7417 4,6904 6,3246 5,6569 5,6569 6 6,3246 5,5678 5,9161 5,1962 5,0990 4,8990 4,8990 3,4641 3,7417 5,0990 4 5,2915 5,2915 5,8310 5,6569 4,3589 5,0990 5,2915 4,8990 5,0990 5,2915 4,7958 5,1962 5,1962 105, 125-127) 5,2915 4,2426 4,6904 5,4772 6,4807 6,6332 5,6569 4,6904 4,2426 4,6904 4,4721 4,2426 5,0990 5,4772 5,0990 6,4807 6,1644 5,6569 6,3246 6,6332 5,8310 5,8310 6,3246 6,1644 4,6904 4,4721 5,0990 4,8990 5,0990 4 4,4721 4 5,2915 3,7417 6,1644 6,1644 5,6569 5,6569 5,6569 6 6,3246 6,1644 4,8990 4,6904 4,8990 4,6904 4,8990 4,2426 4,8990 4,4721 5,0990 4,4721 3,7417 0 3,7417 5,2915 5,6569 6,7823 5,6569 5,8310 6,3246 6,1644 6,1644 5,5678 5,1962 5,7446 5,0990 5,4772 4,2426 4,6904 3,1623 6,7823 5,4772 6,3246 6,4807 6,6332 6,2450 6,2450 4,7958 5,8310 5,6569 5,6569 4,8990 5,0990 5,0990 4,6904 5,0990 6 6,4807 6,3246 4,7958 5,8310 5,6569 5,6569 4,8990 5,0990 5,1962 5,1962 5 5,0990 4,2426 5,0990 4,6904 6 6,1644 4,6904 4,4721 4,4721 4,6904 4,8990 4,8990 4,4721 4,8990 4,2426 6,3246 5,8310 5,4772 6 6 4,8990 5,4772 6,1644 5,2915 5,0990 4,8990 5,2915 5,0990 5,8310 4,8990 5,2915 3,7417 5,0990 3,4641 5,6569 5,6569 5,4772 5,0990 5,0990 5,4772 5,6569 5,8310 4,6904 4,4721 4,4721 4,8990 4,8990 4,2426 4,2426 4 4,6904 5,0990Giulio Superti-Furga4,6904 3,7417 (p.0 49) 4,8990 5,4772 6,4807 5,6569 5,2915 6 6 5,8310 4,5826 5 4,5826 5,0990 5,0990 4 5,4772 4,4721 6,4807 5,2915 6,3246 6,1644 5,8310 6,0828 5,7446 4,3589 5,6569 5,6569 5,8310 5,2915 5,2915 5,0990 5,2915 5,4772 6,1644 6,1644 6 5 5,8310 5,8310 5,8310 5,2915 5,4772 5,3852 4,7958 4,5826 6 5,0990 4,6904 3,7417 5,4772 5,4772 3,7417 4,8990 4,6904 5,2915 4,4721 4,4721 4,2426 4 3,7417 5,4772 5,6569 5,0990 5,4772 5,6569 4 4 5,2915 4,4721 5,2915 4,2426 5,2915 5,2915 5,4772 4,4721 4,6904 5,0990 4,2426 5,4772 5,2915 5,2915 5,2915 2,8284 4,2426 4,4721 4,6904 4,2426 5,6569 5,4772 4,6904 5,4772 5,6569 4,4721 4,8990 5,4772 4 4,6904 4,6904 5,2915 4,8990 0 5,2915 6,1644 5,6569 4 4 5,0990 5,0990 5,1962 5,7446 5 6 6 4,8990 5,0990 5,6569 5,4772 5,6569 4,8990 5,0990 5,6569 5 6,4031 5,7446 5,6569 5,8310 5,8310 4,8990 5,0990 5,6569 4,6904 5,8310 5,8310 5,2915 5,0990 5,1962 6 6,1644 5,6569 5,6569 5,8310 5,7446 5,7446 5,7446 6,3246 5,2915 6 5,0990 4,2426 5,0990 5,4772 5,2915 5,4772 5,8310 5,8310 5,6569 5,2915 5,2915 5,0990 4,8990 4,8990 4,8990 4,8990 5,0990 5,6569 5,4772 6,4807 6 5,4772 5,2915 6 6,1644 6,3246 5,6569 5,2915 5,4772 5,4772 5,8310 4,8990 4,8990 3,7417 5,2915 5,6569 5,8310 6,3246 6 6 5,8310 5,6569 6,1644 6,3246 5,2915 4,8990 5,4772 5,4772 5,6569All other5,6569 photos5,6569 by CeMM5,4772 5,2915 0 5,4772 5,8310 5,4772 6 5,8310 5,8310 6,0828 6,2450 6,0828 6,4807 6,6332 5,2915 6 6 6,6332 6,1644 6,4807 6,3246 6,7823 6,4031 7 5,7446 6,3246 6,4807 6,4807 5,6569 6 6 5,6569 6,1644 6,3246 6,1644 5,8310 5,9161 6,6332 6,7823 6,1644 6,1644 6,3246 6,4031 5,9161 5,5678 7,4833 6,6332 6,6332 6,7823 4,8990 5,4772 6,3246 6,6332 6,9282 7,0711 6,4807 6,4807 6,3246 6,3246 6,7823 5,6569 5,4772 5,4772 5,4772 5,6569 5,8310 5,8310 4,8990 5,6569 7,0711 6,3246 6,9282 6,9282 7,0711 6,6332 6,6332 6,7823 6,4807 7,0711 5,6569 5,6569 5,0990 6,1644 5,8310 5,8310 5,4772 6,1644 7,2111 7,0711 6,3246 6,6332 6,7823 6,3246 6,7823 6,4807 6,4807 6,6332 6,1644 6,7823 6,4807 6,1644 5,4772 0 5,8310 5,6569 5,6569 5,6569 5,2915 6,8557 7,2801 6,7082 7,4833 7,3485 6,7823 6,7823 6,7823 4,4721 6,3246 5,6569 5,4772 6,3246 5,5678 7,1414 7,1414 6,6332 6,4807 6,4807 6 6,1644 6,6332 6 6,1644 5,4772 6,1644 6 6,2450 6,6332 6,7823 6,6332 6,3246 6,4807 6,2450 7,1414 7 6,3246 5,2915 5,6569 6 5,6569 5,8310 5,6569 5,2915 5,4772 5,6569 5,4772 5,2915 5,2915 5,6569 6 5,6569 5,4772 6 5,2915 5,6569 5,2915 6,0000 5,4772 5,0990 5,6569 4,8990 5,8310 6 6 5,2915 5,2915 5,6569 5,8310 5,8310 6,1644 6,1644 6 5,8310 5,0990 4,6904 5,4772 5,6569 6,1644 6 5,2915 6 6 4,8990 5,2915 5,2915 5,2915 5,0990Print 5,2915 5,6569 5,6569 5,6569 5,8310 5,8310 0 5,4772 5,2915 5,2915 5,6569 5,7446 6,0828 5,9161 6,1644 6,4807 5,0990 5,6569 5,2915 6 5,0990 5,6569 6 6,1644 5,7446 6,7082 6,0828 5,0990 5,6569 5,8310 4,8990 4,8990 5,2915 4,6904 5,0990 5,2915 5,8310 5,6569 5 5,8310 6,1644 5,4772 5,2915 5,4772 5,1962 6,0828 6,2450 6 5,6569 4,8990 4,6904 4,6904 4,8990 4 5,0990 5,2915 5,6569 4,6904 4,4721 4,4721 4,4721 4,6904 5,0990 5,0990 4,8990 4,8990 4,8990 3,1623 4,2426 4,6904 3,7417 5,8310 4,6904 5,6569 5,2915 5,8310 4,8990 5,0990 5,4772 4,6904 5,8310 5,0990 5,0990 5,2915 4,2426 3,7417 4,2426 4,6904 4,2426 6 5,8310 4,8990 5,6569 6 4,8990 5,2915 5,0990 4,6904 5,0990gugler*5,0990 5,8310 5,2915 4 5,4772 5,6569 5,4772 0 3,7417 4,2426 4,2426 5,3852 6,0828 5,1962 6,4807 6,6332 5,4772 5,4772 5,4772 4,6904 5,6569 4,6904 4,4721 5,2915 5 6,5574 6,0828 5,4772 5,4772 5,4772 4,4721 4,6904 5,4772 4,2426 5,6569 5,4772 4,2426 4,2426 5 5,6569 5,6569 5,4772 5,4772 5,6569 5,5678 6,0828 5,9161 6,4807 5,8310 5,2915 4,8990 4,8990 4,8990 4,4721 5,8310 5,8310 6,3246 5,4772 5,4772 5,2915 5,0990 5,2915 5,2915 5,4772 5,6569 5,2915 5,4772 4,4721 4,4721 5,0990 4,2426 6 5,2915 5,8310 6,1644 6 5,4772 5,6569 6,1644 5,2915 6,1644 5,8310 5,8310 5,8310 4,4721 4,2426 3,7417 4,8990 4,2426 6,3246 6,1644 5,6569 6,3246 6,1644 5,4772 6 6 5,0990 5,6569 5,6569 6,3246 6 4 6 5,6569 5,2915 3,7417 0 4 4,8990 5,7446 6,4031 5,5678 6,9282 6,6332 6 6 6,1644 4,2426 6 5,0990 4,2426 5,4772 5,1962 6,8557 6,7082 5,8310 6,1644 6,1644 5,2915 5,0990 6,1644 5,0990 6,3246 5,2915 4,4721 4,6904 5,3852 6 6,1644 5,4772 6,1644 6 5,5678 6,4031 6,2450 6,7823 5,8310 6 5,6569 5,2915 5,2915 5,0990 5,8310 6,1644 6,3246 5,8310 5,6569 5,4772 5,0990 5,6569 5,0990 5,0990 5,6569 4,8990 5,2915 4,6904 5,0990 5,0990 4,4721 6,1644 5,2915 6 6,1644 6,3246 5,6569 5,6569 6,1644 5,2915 6,4807 5,4772 5,4772 5,2915 5,0990 4,6904 4 5,2915 4,2426 6,6332 6,4807 5,6569 6 6,1644 5,2915 6 6 5,4772 5,6569Paper 5,4772 6,1644 6 5,0990 5,8310 5,6569 5,2915 4,2426 4 0 4,8990 6,0828 6,4031 5,7446 6,6332 6,7823 5,8310Research6 Report 2012 6,1644 5,0990 6,1644 5,2915 5,0990 6 5,3852 6,8557 6,5574 5,2915 5,6569 5,6569 5,2915 5,4772 5,6569 5,0990 6,3246 5,4772 4,6904 4,4721 5,1962 6 6,1644 5,4772 5,8310 6 5,3852 6,5574 6,4031 6,4807 6 5,4772 5,4772 4,8990 5,2915 4,6904 5,4772 5,8310 6 5,2915 5,2915 5,2915 4,8990 5,4772 5,4772 5,4772 5,6569 5,2915 5,2915 4,2426 5,4772 4 4,6904 6,1644 5,2915 6 5,8310 6,1644 5,6569 5,6569 5,6569 5,0990 6 5,6569 5,6569 5,6569 5,0990 4,8990 4,6904 3,4641 4,8990 6,1644 6 5,0990 6 6,1644 5,2915 5,8310 5,4772 5,6569 5,6569Planoart,5,4772 115g 6,1644 5,8310 5,0990 5,8310 5,2915 5,6569 4,2426 4,8990 4,8990 0 5,9161 6,5574 5,9161 6,9282 6,9282 6 5,8310 6 4,6904 4,8990 4 3,7417 4 3,3166 6,2450 6,4031 5,8310 5,8310 5,8310 4,8990 5,2915 6 5,0990 5,0990 5,2915 4,6904 4,2426 5 6 6,1644 5,2915 5,4772 5,6569 5,1962 6,2450 5,9161 4,5826 4,7958 4,5826 5 5,3852 5,5678 4,1231 4,7958 5,1962 5,1962 4,7958 4,5826 4,3589 5 5 6,0828 5,5678 5,5678 5,7446 5,7446 4,7958 5,7446 5,9161 5,1962 4,5826 4,5826 4,5826 4,7958 5,3852 4,5826 5 4,7958 5,1962 4,5826 5,5678 5,5678 5,3852 5 5 5,3852 5,7446 5,5678 4,3589 4,3589 3,6056 5,3852 5 4,1231 5 5,1962 4,7958 5Invercote,5,1962 300g5,5678 4,5826 5,1962 6,0828 6,8557 5,7446 5,3852 5,7446 6,0828 5,9161 20090 4 2,4495 5,7446 5,3852 4,35892012 5,1962 5,3852 6,0828 5,9161 5,9161 5,7446 5,3852 5,6569 4,2426 4,4721 5,3852 5,7446 5,9161 5,1962 4,7958 5,7446 5 6,0828 5,5678 5,9161 6,0828 4,6904 5,5678 5,5678 5,3852 5,9161 5,7446 4,8990 5,0990 4,6904 5,1962 4,5826 4,7958 5,1962 6,0828 6,2450 5 5 5 4,5826 5 4,7958 5 5,7446 5,5678 6,7082 6,5574 6,0828 6,4031 6,4031 5,5678 6,2450 6,5574 5,9161 4,5826 5,1962 5,5678 5,3852 5,5678 5,1962 5,1962 5 5,5678 4,3589 5,9161 5,9161 6,0828 5,7446 5,7446 6,0828 6,4031 6,2450 4,7958 4,7958 4,3589 6,0828 5,7446 4,7958 4,5826 5,3852 5,7446 5,1962 5,1962 5,1962 5 5,7446 6,2450 7,2801 6,0828 6,0828 6,4031 6,4031 6,5574 4 0 3,4641 5 4,5826 3,8730 5,3852 5,1962 6,7082 6,0828 6,5574 6,4031 6,4031 6,3246 4,6904 4,6904 5,3852 5,9161 6,0828 5,7446 5,3852 5,1962 5,5678 6,0828 6,0828 6,5574 6,7082 5,6569 5,9161 6,2450 5,9161 5,3852 5,1962 5,4772 4,2426 5,2915

5 4,5826 4,5826 4,7958 5,3852 5,5678 3,8730 4,7958 5,1962 5,1962 4,7958 4,5826 4,1231 4,7958 5,1962 6,0828 5,9161 5,3852 5,7446 5,7446 4,5826 5,3852 5,9161 5 4,5826 4,5826 5 5,1962 5,3852 5 5 5,1962 5 5,0000 5,1962 5,1962 5,3852 4,7958 4,7958 5,1962 5,5678 5,5678 4,7958 4,7958 3,6056 5,5678 5,1962 4,5826 5 5,5678 4,5826 5 5 5,7446 4,5826 5 6,0828 6,7082 5,9161 5,1962 5,5678 5,7446 5,9161 2,4495 3,4641 0 5,7446 5,3852 4,7958 5,1962 5,7446 5,9161 5,7446 5,9161 5,5678 5,5678 5,6569 4,4721 4,6904 5,1962 5,3852 5,5678 5,1962 4,7958 5,3852 5,0000 6,0828 5,5678 5,7446 5,9161 5,0990 5,3852 5,7446 5,3852 5,5678 5,3852 4,8990 4,8990 4,8990 5,2915 5,2915 5,8310 6,1644 6,9282 7,0711 6 5,6569 5,4772 4,6904 5,6569 5,6569 5,6569 5,8310 5,8310 6,9282 6,4807 6,4807 6,6332 6,9282 6,1644 6,3246 7,0711 6,4807 5,8310 5,0990 4,8990 4,8990 5,2915 5,2915 5,4772 5,0990 6 5,2915 6,4807 6,4807 6 6,1644 6,1644 6,3246 6,6332 6,6332 6 5,8310 5,6569 5,0990 5,0990 4,6904 5,2915 5,4772 5,0990 4,8990Fonts 5,0990 5,0990 5,0990 6 6,4807 7,4833 6,1644 6,4807 6,9282 6,6332 6,9282 5,7446 5 5,7446 0 3,4641 3,7417 5,2915 5,0990 7,2111 6 6,7823 6,9282 6,6332 6,7082 6,0828 5,7446 4,8990 5,2915 5,4772 5,2915 5,2915 4,4721 5,6569 6 6,6332 6,9282 6,7823 5,5678 5,6569 5,6569 6,1644 5,4772 5,6569 5,7446 5,1962 5,9161 5,2915 5,0990 5,6569 5,8310 6,6332 6,7823 5,6569 5,6569 5,6569 4,8990 5,8310 5,8310 5,6569 6 5,8310 7,0711 6,6332 6,6332 6,7823 6,9282 6,1644 6,4807 7,0711 6,4807 5,6569 5,6569 4,6904 5,2915 5,4772 5,6569 6 5,0990 6,1644 4,8990 6,4807 6,4807 6,1644 6 6 6,4807 6,4807 6,4807 5,6569 5,4772 5,6569 4,6904 4,4721 4,8990 5,2915 5,4772 5,6569 5,4772Sys (by 5,8310Fabrizio5,4772 Schiavi)5,0990 6 6,6332 7,3485 6,4807 6,6332 6,6332 6,7823 6,9282 5,3852 4,5826 5,3852 3,4641 0 4 5,6569 5,4772 6,7823 6,3246 6,7823 6,4807 6,3246 6,5574 5,7446 5,7446 4,6904 5,0990 5,0990 6 5,6569 4,6904 6 6,3246 6,4807 6,7823 6,9282 5,7446 4,8990 5,0990 6 5,8310 5,6569 5,5678 4,7958 5,5678 5,0990 4 4,8990 4,8990 5,8310 6 4,6904 4,2426 4,2426 4,2426 4,6904 4,4721 4,2426 4,6904 4,4721 5,8310 5,2915 5,6569 5,4772 5,8310 4,8990 5,6569 6 5,2915 4,4721 4 4,4721 4,6904 5,2915 4 4,4721 3,7417 4,8990 4 5,6569 5,6569 5,0990 4,8990 4,8990 5,0990 5,6569 5,4772 4,8990 4,6904 4,4721 4,8990 4,8990 2,8284 3,7417 4,2426 4,6904 4,4721DTL Documenta4,6904 4,2426 4 4,8990 5,2915 6,7823 5,0990 5,4772 6 5,8310 6 4,3589 3,8730 4,7958 3,7417 4 0 4,6904 4 6,3246 5,0990 5,8310 6 5,8310 5,7446 5,3852 4,5826 4,6904 5,2915 5,4772 4,6904 4,6904 4,4721 4,4721 5,0990 5,4772 6 5,8310 4,3589 5,4772 5,4772 5,2915 4,6904 4,8990 5 4,3589 5 5,6569 4,8990 4 5,6569 6 6,1644 5,0990 4,6904 4,8990 4,6904 3,7417 3,7417 4,4721 4,8990 5,6569 6 6 5,6569 5,8310 6,1644 5,2915 5,6569 6 5,6569 5,0990 3,7417 4,6904 4,4721 3,1623 3,7417 3,7417 4,8990 4,6904 4,8990 5,8310 5,8310 5,6569 5,0990 5,0990 5,4772 5,8310 5,6569 5,6569 5,4772 4,4721 4,8990 5,0990 4,2426 5,2915 5,4772 4,4721 3,7417(by Frank3,7417 E. Blokland)4,6904 5,4772 5,0990 6 6,7823 5,6569 5,4772 6 6 5,8310 5,1962 5,3852 5,1962 5,2915 5,6569 4,6904 0 4,6904 6,3246 5,6569 5,6569 6 6 5,5678 6,2450 5,7446 5,2915 5,0990 5,0990 4,2426 4,4721 5,2915 4,2426 5,4772 5,4772 6 5,8310 4,5826 5,2915 5,4772 4,6904 5,4772 5,6569 5,1962 5,3852 5,5678 5,4772 4,6904 4,8990 5,6569 6,1644 6,3246 5,6569 4,8990 4,4721 4,6904 4,6904 4,4721 5,2915 5,4772 5,2915 6,1644 5,6569 6,1644 5,8310 6,1644 5,0990 6,3246 6 5,4772 5,0990 4,6904 5,2915 5,0990 5,2915 4,2426 4,6904 4,2426 5,2915 3,7417 6,4807 6,4807 6 5,8310 5,2915 5,4772 5,8310 5,8310 5,2915 5,0990 5,0990 5,4772 5,4772 4,4721 5,0990 3,7417 5,4772 4,6904 4,6904 3,1623 4,4721 5,6569 6 6,7823 5,2915 5,4772 6,1644 6,1644 6 5,3852 5,1962 5,7446 5,0990 5,4772 4,0000 4,6904 0 6,3246 4,6904 5,8310 6,1644 6 5,7446 6,4031 5,1962 5,4772 5,0990 5,2915 4,2426 4,2426 4,4721 4,0000 4,2426 5,4772 6,1644 6 4,3589 5,2915 5,2915 5,2915 4,2426 4,4721 5 5,3852 5,3852 6,9282 6,3246 6 5,6569 5,6569 5,8310 5,0990 6,3246 6,6332 6,7823 6,1644 6,1644 5,8310 5,4772 6 6,1644 6,1644 6,3246 6 6,1644 4,8990 5,4772 3,7417 4,6904 6,3246 6 6,3246 6,6332 6,4807 6,3246 6,3246 6,4807 5,6569 6,4807 6,3246 6,3246 6,3246 5,2915 5,0990 4,8990 4,4721 5,2915 6,7823 6,6332 6,1644 6,7823 6,6332 6,1644 6,6332 6,3246 6,1644 6,4807 6,3246 6,7823 6,4807 5,4772 6,6332 4,4721 6 4,6904 4,2426 5,0990 4,6904 6,0828 6,7082 5,9161 7,2111 6,7823 6,3246 6,3246 6,3246 0 5,6569 4,6904 3,1623 4,8990 4,5826 6,7082 7,1414 6,4807 6,3246 6,3246 5,6569 5,4772 6,4807 5,6569 5,8310 4,6904 4,6904 4,8990 5,9161 6,1644 6,3246 6 6,1644 6 5,7446 6,7082 6,5574 6,4807 5,2915 5,8310 5,6569 6,1644 6,3246 5,4772 5,4772 5,2915 5,8310 5,6569 5,4772 5,4772 5,2915 5,6569 6,1644 6 6,3246 5,8310 6,1644 5,0990 6,3246 5,4772 5,4772 5,6569 5,2915 6,1644 6,3246 6,1644 5,6569 5,6569 5,4772 5,4772 5,6569 6,6332 6,6332 6,4807 5,8310 5,0990 5,0990 4,2426 5,8310 6,1644 6 5,6569 6,3246 6,3246 5,4772 5,4772 5,2915 5,4772 5,6569 5,6569 5,4772 5,2915 5,6569 6,1644 6,3246 5,0990 5,6569 6 6,1644 4,8990 5,9161 6,0828 5,7446 6 6,3246 5,0990 5,6569 4,6904 5,6569 0 4,8990 4,8990 4,8990 4,5826 6,4031 6,0828 5,6569 5,8310 6 5,0990 5,0990 5,4772 4,8990 2,8284 5,6569 5,6569 5,4772 5,1962 6 6,3246 5,6569 4,4721 4,6904 5,3852 6,0828 6,0828 6,6332 6 5,4772 5,6569 5,6569 5,6569 4,8990 5,4772 5,8310 6,1644 5,2915 5,2915 5,4772 5,0990 5,6569 5,6569 5,6569 6 5,4772 5,6569 4,4721 5,4772 4 4,8990 6,1644 5,0990 6 6 6,1644 5,2915 5,4772 6 5,2915 6,3246 6,1644 6,1644 6,1644 4,8990 4,6904 4,6904 3,7417 4,4721 6,4807 6,3246 5,6569 6,3246 6,4807 5,4772 6,1644 6 5,6569 5,6569 5,6569 6,3246 6,3246 4,8990 6,4807 5,6569 5,6569 4,6904 5,0990 5,2915 4 5,9161 6,5574 5,9161 6,7823 6,7823 5,8310 5,6569 5,8310 4,6904 4,8990 0 4,2426 4,6904 3 6,7082 6,5574 5,8310 6 6 5,0990 5,2915 6 4,8990 5,2915 5,2915 5,0990 4,8990 5 6,1644 6,3246 5,0990 5,4772 5,6569 5,3852 6,5574 6,4031 6,6332 6 5,6569 5,2915 5,0990 5,2915 4,6904 6 6,3246 6,4807 5,8310 5,8310 5,4772 5,0990 5,6569 5,6569 5,6569 6 5,4772 5,6569 4,6904 5,0990 4,6904 5,0990 6 5,6569 6 6,3246 6,1644 6 6 6,1644 5,2915 6,1644 6 6 6 4,8990 4,4721 4,8990 3,1623 4,6904 6,4807 6,3246 5,8310 6,4807 6,3246 5,8310 6,3246 6,1644 5,8310 6,1644 6 6,4807 6,1644 5,0990 6,3246 5,4772 6 4,4721 4,2426 5,0990 3,7417 5,7446 6,4031 5,5678 6,9282 6,4807 6 6 6,1644 3,1623 4,8990 4,2426 0 4 3,6056 6,2450 6,8557 6 6,1644 6,1644 5,4772 5,2915 6,3246 5,4772 5,4772 5,4772 3,7417 4 5,3852 6 6,1644 5,4772 5,8310 5,6569 5,1962 6,4031 6,2450 6,4807 6,1644 5,8310 5,4772 5,6569 5,8310 4,4721 6,1644 6,4807 6,4807 6 6 5,2915 4,6904 5,4772 6 5,8310 6,4807 6 5,6569 4,4721 6,1644 4,8990 4,8990 6,4807 6 6 6,1644 6,4807 6 6,1644 6 4,8990 5,8310 6,4807 6,4807 6,3246 5,0990 5,2915 4,8990 3,7417 5,4772 6,3246 6,1644 5,8310 6,4807 6,1644 5,6569 6,1644 5,6569 6,1644 6,3246 6,3246 6,6332 5,8310 5,6569 6,7823 6,3246 6,1644 5,2915 5,4772 6 4 5,3852 6,4031 5,5678 6,6332 6,3246 5,8310 6 6 4,8990 4,8990 4,6904 4 0 4,1231 5,5678 6,2450 6,1644 6,3246 6,4807 5,8310 5,4772 6,4807 5,8310 5,6569 5,8310 5,0990 5,2915 5,3852 6,1644 6,1644 4,8990 6 5,8310 5,1962 6,0828 5,9161 6,5574 5,9161 5,5678 5,5678 5,5678 5,7446 4,7958 5,3852 5,9161 6,0828 5,3852 5,3852 5,3852 4,7958 5,5678 5,7446 5,7446 6,0828 5,5678 5,7446 4,3589 5,5678 4,1231 4,7958 6,0828 5,1962 5,9161 5,9161 6,0828 5,5678 5,5678 5,7446 5 6,0828 6,0828 6,0828 6,0828 4,7958 4,5826 4,5826 3 4,5826 6,2450 6,0828 5,3852 6,0828 6,2450 5,3852 6,0828 5,7446 5,7446 5,7446 5,5678 6,2450 6,0828 5 6,4031 5,5678 5,7446 5 5,1962 5,3852 3,3166 5,6569 6,3246 5,6569 6,7082 6,5574 5,7446 5,5678 5,7446 4,5826 4,5826 3 3,6056 4,1231 0 6,1644 6,3246 5,7446 5,7446 5,7446 5 5,1962 5,9161 5 5 5,3852 5 4,7958 4,2426 5,9161 6,0828 5,1962 5,3852 5,5678 4,6904 6,1644 6 5,7446 5,7446 5,5678 6,2450 6,5574 6,7082 5,5678 5,9161 6,2450 6,2450 5,7446 5,7446 5,1962 5,7446 6,2450 6,8557 6,7082 6,5574 6,8557 6,5574 6,0828 6,7082 6,5574 6,4031 5,7446 5,7446 5,7446 5,9161 6,2450 5,7446 5,9161 5,7446 5,9161 5,5678 6,4031 6,4031 6,2450 5,9161 6,2450 6,5574 6,0828 6,7082 5,3852 5,3852 4,5826 6,0828 5,7446 5 5,5678 5,9161 6,2450 6,0828 5,9161 6,2450 5,7446 6,4031 7 7,1414 6,7082 6,5574 6,8557 6,8557 6,2450 4,2426 4,6904 4,4721 6,0828 5,7446 5,3852 6,2450 6,4031 6,7082 6,4031 6,7082 6,2450 5,5678 6,1644 0 4,8990 5,5678 6,0828 6,2450 5,9161 5,5678 6,2450 5,9161 6,0828 5,5678 6,7082 6,8557 5,4772 6,2450 6,2450 5,9161 5,5678 5,3852 5,4772 5,2915 5,4772 4,5826 4,3589 5,3852 5,1962 6,4031 6,5574 5,3852 4,5826 4,7958 5 5,1962 5 4,5826 5,3852 4,7958 6,4031 6,2450 5,9161 6,4031 6,0828 5,5678 6,0828 6,4031 5,9161 4,3589 5 5,3852 5,1962 6,0828 5 5,1962 4,3589 5,5678 4,5826 6,0828 6,0828 5,9161 5,3852 5,7446 6,0828 6,4031 6,2450 4,5826 4,1231 4,3589 5,3852 5,3852 4,5826 4,5826 4,5826 5,7446 5,3852 5,1962 4,7958 4,3589 5,7446 5,7446 7,1414 6,0828 6,0828 6,7082 6,5574 6,4031 4,4721 4,6904 4,6904 5,7446 5,7446 4,5826 5,7446 5,1962 7,1414 6,0828 6,5574 6,8557 6,2450 6,3246 4,8990 0 5,7446 5,7446 5,9161 5,3852 5,3852 5,1962 5,1962 5,5678 6,0828 6,7082 6,5574 4,8990 6,0828 6,0828 5,7446 5,5678 5,7446 5,4772 4,8990 4,6904 5,6569 5,0990 5,4772 6 5,6569 5,8310 5,2915 5,2915 5,6569 4,8990 5,2915 5,0990 4,8990 5,2915 6 5,6569 5,4772 6 5,2915 5,6569 4,8990 6 6 5,2915 5,6569 4,6904 4,4721 4,8990 5,0990 5,0990 5,0990 5,6569 5,4772 5,8310 5,8310 5,8310 5,6569 5,4772 4,6904 4,8990 5,4772 5,2915 6,3246 6,1644 5,0990 4,4721 4,4721 4,2426 5,0990 5,4772 4,6904 4,4721 5,0990 5,8310 5,6569 5,6569 6,3246 6,6332 5,0990 5,4772 5,8310 5,2915 5,8310 5,3852 5,3852 5,1962 4,8990 4,6904 4,6904 5,2915 5,4772 6,4807 5,6569 5,8310 6 6,1644 5,7446 5,5678 5,7446 0 3,1623 3,4641 4,4721 4,4721 3,4641 4,2426 5,4772 5,2915 5,6569 5,4772 4,3589 4 4,4721 5,0990 5,0990 5,2915 4,7958 5,5678 6,0828 5,6569 5,0990 5,2915 6,1644 6 6,1644 5,4772 5,0990 5,4772 4,8990 5,0990 5,0990 5,0990 5,2915 6,1644 6 5,8310 6,1644 5,6569 6 4,8990 6,1644 5,8310 5,2915 5,6569 4,6904 4,4721 4,8990 4,8990 5,0990 5,0990 5,4772 5,4772 5,6569 5,8310 5,8310 5,8310 5,6569 5,0990 5,2915 5,6569 5,4772 6 6 4,8990 4 3,7417 4,6904 5,6569 5,0990 4,8990 4,4721 4,8990 5,6569 5,6569 5,8310 6,4807 6,4807 5,6569 5,4772 6,1644 5,6569 5,8310 5,7446 5,9161 5,3852 5,2915 5,0990 5,2915 5,0990 5,0990 6,3246 5,8310 6 6,1644 6,3246 5,7446 6,0828 5,7446 3,1623 0 2 4 4 3,1623 4 5,0990 5,0990 5,6569 5,4772 4,3589 3,1623 3,4641 5,0990 4,8990 5,0990 4,7958 5,7446 5,9161 5,6569 5,2915 5,2915 6,1644 6 6,1644 5,6569 5,0990 5,4772 5,0990 5,0990 5,0990 5,0990 5,4772 6,1644 6 6 6,1644 5,8310 6,1644 5,0990 6,1644 5,8310 5,4772 5,6569 4,6904 4,4721 4,8990 4,8990 5,0990 5,0990 5,4772 5,6569 5,8310 5,8310 5,8310 5,8310 5,6569 5,0990 5,4772 5,8310 5,4772 6 6 5,0990 3,7417 4,2426 4,8990 5,8310 5,2915 4,8990 4,6904 4,8990 5,6569 5,8310 5,8310 6,4807 6,4807 5,8310 5,4772 6,1644 5,6569 5,8310 5,9161 6,0828 5,5678 5,4772 5,0990 5,4772 5,0990 5,2915 6,3246 6 6 6,1644 6,4807 5,7446 6,2450 5,9161 3,4641 2 0 4 4,2426 3,4641 4 5,2915 5,0990 5,6569 5,4772 4,3589 3,1623 3,7417 5,0990 5,0990 5,2915 4,7958 5,9161 5,9161 5,6569 4,6904 4,2426 5,4772 5,0990 5,4772 4,8990 4,4721 4,6904 5,0990 4 4 4,2426 4,6904 5,4772 5,2915 5,2915 5,4772 5,0990 5,4772 4,2426 5,2915 5,0990 4,6904 4,8990 3,1623 4,6904 4,8990 4,6904 4 3,7417 4,6904 4,8990 5,0990 5,6569 5,6569 5,2915 4,8990 4,2426 4,6904 5,0990 4,8990 5,4772 5,2915 4,2426 4,8990 5,0990 4 5,0990 4,4721 4,4721 4,2426 3,4641 4,8990 5,2915 4,8990 5,6569 6 4,8990 4,4721 5,2915 5,2915 4,8990 5,1962 5,7446 5,1962 5,2915 6 4,6904 4,2426 4,2426 5,6569 5,0990 5,0990 5,4772 5,8310 5 5,9161 5,3852 4,4721 4 4 0 2 4,2426 2,4495 4,2426 4 5,0990 4,6904 3,3166 4,4721 4,6904 4,2426 4,4721 4,6904 4,3589 5,3852 5,1962 5,4772 4,2426 4,0000 5,2915 5,0990 5,2915 4,4721 4,6904 4,8990 5,0990 4,2426 4,2426 4,4721 4,6904 5,6569 5,4772 5,2915 5,6569 5,0990 5,4772 4,2426 5,4772 5,2915 4,6904 4,6904 3,4641 4,4721 5,0990 4,4721 4,2426 4 4,8990 4,8990 4,6904 5,8310 5,8310 5,6569 5,0990 4,4721 4,6904 5,0990 5,0990 5,2915 5,0990 4,2426 5,0990 4,6904 4 5,0990 4,4721 4,6904 4,2426 3,7417 5,0990 5,2915 5,0990 6 6,1644 4,8990 4,6904 5,0990 5,4772 5,2915 4,7958 5,3852 4,7958 5,2915 5,6569 4,6904 4,4721 4,2426 5,4772 5,0990 5,2915 5,2915 5,4772 5,1962 5,5678 5,3852 4,4721 4 4,2426 2 0 4,2426 2,8284 4,2426 4 4,8990 5,0990 3,6056 4 4,4721 4 4,4721 4,2426 4,1231 5 5,1962 5,0990 4,4721 5,4772 5,6569 6 6,1644 5,4772 4,8990 4,8990 3,7417 5,2915 5,0990 5,0990 5,4772 5,6569 6 5,8310 6,1644 5,6569 6 4,8990 6,1644 5,8310 5,2915 5,0990 4,6904 4,6904 4,6904 4,8990 5,0990 5,0990 4,8990 5,6569 5,0990 6 6 5,8310 5,6569 5,0990 5,2915 5,8310 5,6569 5,8310 5,6569 5,0990 4,6904 4,6904 4,6904 5,0990 4,4721 4,6904 4,2426 5,0990 5,0990 5,0990 5,6569 6 6,6332 5,2915 5,4772 6,1644 5,6569 6 5,7446 5,1962 5,3852 4,4721 4,6904 4,4721 5,2915 4,4721 6,4807 5,4772 6 6,3246 6,4807 5,9161 6,2450 5,1962 3,4641 3,1623 3,4641 4,2426 4,2426 0 4 4,6904 5,0990 6 5,8310 4,5826 4 4,4721 5,2915 4 4,2426 5 5,1962 5,7446 5,4772 4,4721 4,2426 5,2915 5,0990 5,2915 4,6904 4,2426 4,2426 4,8990 4,0000 3,4641 4 4,6904 5,2915 5,0990 5,0990 5,0990 4,8990 5,2915 4 5,2915 4,8990 4,4721 4,6904 3,1623 4,4721 4,6904 4,6904 3,7417 3,7417 4,6904 4,8990 5,0990 5,4772 5,4772 5,2915 4,6904 4 4,4721 5,0990 4,6904 5,4772 5,2915 4,2426 4,8990 5,0990 3,7417 4,8990 4,4721 4,2426 4 4 4,6904 5,2915 4,6904 5,6569 6 4,6904 4,2426 5,0990 5,0990 5,0990 5 5,5678 5 5,6569 6 4,4721 4,2426 4 5,6569 4,8990 4,8990 5,4772 5,8310 5 5,9161 5,1962 4,2426 4 4 2,4495 2,8284 4 0 4 4 5,0990 4,8990 3,3166 4,4721 4,6904 4,2426 4 4,2426 4,1231 5,3852 5,3852 6,1644 4,8990 5,4772 5,8310 6,3246 6,4807 5,8310 5,0990 4,8990 5,4772 5,2915 5,0990 5,4772 5,6569 5,8310 6,3246 6,1644 6,3246 6 6,3246 5,2915 6,4807 5,2915 5,6569 5,2915 4,8990 5,8310 6 5,8310 5,2915 5,2915 5,0990 5,8310 5,2915 6,6332 6,6332 6,4807 6 5,4772 5,6569 4,8990 6 5,8310 5,6569 5,2915 6 6 5,0990 5,2915 4,6904 5,6569 5,2915 5,2915 5,0990 5,4772 5,8310 6,1644 6,1644 5,0990 5,6569 6,3246 6,3246 5,0990 6,0828 6,0828 6,0828 6 6,3246 5,0990 5,4772 4,2426 5,8310 2,8284 5,2915 5,4772 5,6569 5 6,0828 5,5678 5,4772 5,0990 5,2915 4,2426 4,2426 4,6904 4 0 4,8990 5,8310 5,6569 4,7958 5,4772 5,8310 5,4772 3,7417 4 5,1962 5,7446 5,9161 6 5,0990 5,0990 5,8310 5,4772 5,8310 5,2915 5,2915 5,6569 5,8310 5,2915 5,0990 5,0990 5,6569 6,1644 6 6 6,3246 5,8310 6,1644 5,0990 6,3246 4,2426 4,8990 5,2915 4,6904 5,0990 5,6569 5,4772 5,0990 5,0990 5,6569 5,8310 5,6569 6,3246 6,3246 6 5,6569 5,0990 4,8990 5,4772 5,6569 6 5,8310 5,2915 5,8310 5,6569 4,8990 5,8310 5,4772 5,4772 5,2915 5,2915 6 6,1644 5,8310 6,3246 5,4772 5,2915 5,4772 5,2915 5,4772 5,2915 5,5678 6,0828 5,5678 6,6332 6,4807 5,4772 5,4772 5,4772 4,6904 5,6569 5,2915 5,4772 5,8310 5,3852 5,5678 6,0828 5,2915 5,0990 5,0990 4 4 5,0990 4 4,8990 0 5,6569 5,6569 4,5826 5,0990 5,2915 4,8990 4,4721 4,2426 5 5,9161 5,7446 6,4807 5,8310 5,6569 5,2915 5,0990 5,0990 4,6904 5,8310 6,1644 6,4807 5,8310 5,6569 5,4772 4,8990 5,6569 5,2915 5,2915 6 5,0990 5,4772 4,6904 5,2915 5,4772 5,0990 6 5,4772 5,8310 6,1644 6 5,8310 5,8310 6,1644 5,0990 6,1644 5,8310 5,8310 5,8310 5,0990 4,4721 4,6904 4,4721 4,4721 6,3246 6,3246 5,8310 6 6 5,6569 6,3246 6,1644 5,6569 6 5,8310 6,4807 6,1644 5,2915 6,1644 6,1644 5,8310 4,2426 4,4721 4,6904 4,6904 5,9161 6,5574 5,7446 6,9282 6,7823 6 6 6,1644 4,6904 5,6569 5,0990 3,7417 5,0990 5 6,7082 6,7082 5,6569 5,6569 5,6569 5,0990 4,8990 6 5,0990 5,8310 5,6569 0 2 5 5,6569 5,6569 5,0990 6,3246 6,1644 5 6,4031 6,2450 6,7823 6 5,8310 5,4772 5,0990 5,2915 4,8990 5,6569 6 6,3246 5,6569 5,6569 5,2915 4,6904 5,4772 5,0990 5,0990 5,8310 4,8990 5,2915 4,4721 5,0990 5,2915 4,8990 6,1644 5,2915 6 6,1644 6,1644 5,6569 5,6569 6 4,8990 6,3246 5,6569 5,6569 5,4772 4,8990 4,4721 4,4721 4,2426 4,2426 6,4807 6,4807 5,6569 6 6,1644 5,4772 6,1644 6 5,4772 5,8310 5,6569 6,3246 6 5,0990 5,8310 6 5,6569 4,2426 4,6904 4,4721 4,2426 6,0828 6,7082 5,9161 6,7823 6,9282 5,8310 5,8310 6 4,8990 5,4772 4,8990 4 5,2915 4,7958 6,8557 6,5574 5,4772 5,4772 5,4772 4,6904 5,0990 5,8310 4,8990 5,6569 5,6569 2 0 4,7958 5,8310 6 5,2915 6,1644 6,3246 5,1962 6,5574 6,2450 5,3852 4,7958 4,5826 5,5678 5,1962 5,3852 5 4,3589 5 5,1962 4,3589 4,3589 4,3589 4,7958 5,1962 5,1962 4,7958 5,7446 5 5,3852 4,5826 5,7446 5,3852 5 5 3,8730 4,3589 4,5826 5,0000 3,8730 4,3589 4,3589 5 4,7958 5,7446 5,7446 5,1962 5 4,1231 4,5826 5 4,7958 5 4,7958 4,3589 4,5826 4,7958 3,6056 5,1962 4,3589 4,7958 4,5826 4,3589 4,7958 5 5,1962 5,9161 6,2450 5 5 5,3852 5,1962 5 4,6904 5,6569 5,0990 5,5678 5,7446 4,3589 4,5826 4,3589 5,9161 5,1962 5 5,3852 5,3852 4,2426 5,4772 4,8990 4,3589 4,3589 4,3589 3,3166 3,6056 4,5826 3,3166 4,7958 4,5826 5 4,7958 0 4,7958 4,5826 3,8730 5 5,1962 3,1623 5,2915 4,8990 5,4772 4,8990 5,0990 6 5,8310 6 5,2915 5,2915 5,6569 5,0990 5,2915 5,2915 5,2915 5,4772 6,3246 6,1644 6 6,3246 5,8310 6,1644 5,0990 6,3246 6 5,4772 5,4772 4,8990 4,2426 5,0990 4,6904 5,2915 5,2915 5,6569 5,6569 5,4772 6,1644 6,1644 6,1644 5,8310 5,2915 5,4772 5,8310 5,6569 5,8310 5,8310 5,0990 4 3,7417 4,8990 5,8310 5,2915 5,0990 4,6904 5,0990 5,8310 5,8310 6 6,6332 6,6332 5,8310 5,6569 6 6 6 5,5678 5,9161 5,3852 5,6569 4,8990 5,4772 5,2915 5,2915 6,1644 6 6,1644 6,0000 6,1644 5,9161 6,2450 6,0828 4 3,1623 3,1623 4,4721 4 4 4,4721 5,4772 5,0990 5,6569 5,8310 4,7958 0 2,4495 4,6904 5,0990 4,8990 4,5826 5,3852 5,5678 5,0990 5,2915 5,2915 6,1644 6 6,1644 5,6569 5,4772 5,8310 5,4772 5,4772 5,2915 5,4772 5,8310 6,1644 6,3246 6 6,4807 6,1644 6,4807 5,4772 6,4807 6,1644 5,8310 5,6569 5,0990 4 4,6904 4,8990 5,0990 5,4772 5,4772 6 5,4772 6,3246 6,3246 6 6 5,2915 5,8310 6,1644 5,8310 5,6569 5,6569 5,4772 3,7417 3,4641 4,8990 6,1644 5,2915 5,2915 5,0990 5,2915 5,6569 5,8310 6,1644 6,7823 6,7823 6,1644 5,6569 6,1644 6,1644 6,1644 5,5678 6,2450 5,7446 5,6569 5,0990 5,4772 5,4772 5,2915 6,3246 6,3246 6,3246 6,1644 6,1644 6,0828 6,2450 6,0828 4,4721 3,4641 3,7417 4,6904 4,4721 4,4721 4,6904 5,8310 5,2915 5,6569 6 4,5826 2,4495 0 4,8990 5,4772 5,2915 4,3589 5,7446 5,3852 5,8310 4,8990 4,6904 5,6569 5,2915 5,2915 5,0990 4,8990 5,4772 5,6569 4,8990 4,8990 4,4721 4,8990 6 5,0990 5,4772 6,1644 5,2915 5,2915 5,0990 6,1644 5,8310 5,4772 5,0990 4,4721 4,8990 5,4772 5,0990 4,8990 4,6904 5,2915 5,0990 5,2915 6,1644 6,1644 6 5,0990 4,6904 5,0990 5,4772 5,0990 5,4772 5,2915 4,8990 5,4772 5,2915 4,6904 5,4772 5,0990 5,2915 5,0990 4,8990 5,6569 5,8310 5,6569 6,1644 6,6332 5,4772 5,4772 5,4772 5,4772 5,2915 5,3852 5,9161 5,3852 6,1644 6 5,2915 4,6904 5,2915 6 5,6569 5,0990 5,4772 4,8990 5,1962 5,9161 5,7446 5,0990 5,0990 5,0990 4,2426 4 5,2915 4,2426 5,4772 4,8990 5,0990 5,2915 3,8730 4,6904 4,8990 0 5,2915 5,0990 4,1231 5,1962 5,3852 6,1644 4,6904 5,4772 5,8310 6,1644 6,3246 5,6569 5,0990 4,6904 5,0990 5,2915 4,8990 5,2915 5,6569 5,8310 6,1644 6 6 5,8310 6,1644 5,0990 6,1644 5,4772 5,4772 5,2915 4,6904 5,6569 5,8310 5,8310 5,0990 5,0990 5,0990 5,8310 5,2915 6,1644 6,1644 6 5,8310 5,2915 5,4772 5,2915 5,8310 6 5,8310 5,2915 5,8310 5,8310 4,8990 5,2915 4,6904 5,4772 5,0990 5,0990 4,8990 5,2915 5,6569 6,1644 6,3246 5,2915 5,4772 6,1644 5,8310 5,4772 5,9161 5,3852 5,5678 5,4772 5,8310 4,6904 5,4772 4,2426 6,1644 4,4721 5,4772 5,8310 6 5,3852 5,5678 5,5678 5,0990 4,8990 5,0990 4,4721 4,4721 4 4 3,7417 4,4721 6,3246 6,1644 5 5,0990 5,4772 5,2915 0 1,4142 5 5,3852 5,9161 6 4,4721 5,2915 5,6569 6 6,1644 5,4772 5,2915 4,8990 5,2915 5,4772 5,0990 5,4772 5,8310 6 6,3246 6,1644 6,1644 6 6,3246 5,2915 6,3246 5,6569 5,6569 5,0990 4,8990 5,4772 6 5,6569 5,2915 5,2915 5,2915 6 5,0990 6,3246 6,3246 6,1644 6 5,4772 5,6569 5,4772 6 5,8310 5,6569 5,4772 6 5,6569 5,0990 5,4772 4,8990 5,6569 5,2915 5,2915 5,0990 5,4772 5,8310 6,3246 6,4807 5,4772 5,6569 6 6 5,6569 5,7446 5,1962 5,3852 5,6569 5,6569 4,8990 5,6569 4,4721 6 4,6904 5,6569 5,6569 5,8310 5,5678 5,3852 5,7446 5,2915 5,0990 5,2915 4,6904 4,2426 4,2426 4,2426 4 4,2426 6,1644 6,3246 5,1962 4,8990 5,2915 5,0990 1,4142 0 4,7958 5,1962 5,7446 5,5678 4,7958 4,7958 5,7446 5,3852 5,5678 5,1962 5,1962 5,5678 5,7446 5 5 5 5,3852 5,7446 5,7446 5,3852 6,0828 5,5678 5,9161 5,1962 6,0828 5,5678 5,5678 5,1962 4,5826 4,5826 5,1962 5,1962 4,5826 5 5 5,5678 5 5,9161 5,9161 5,3852 5,5678 4,7958 5,1962 5,1962 5,3852 5,3852 5,1962 5 5 4,7958 4,3589 5,7446 5 5,3852 5,1962 4,7958 5,1962 5,3852 5,7446 6,4031 6,2450 5,1962 5,5678 5,5678 5,3852 5,1962 4,8990 5,4772 4,8990 5,7446 5,5678 5 5,1962 5 5,7446 5,3852 5,3852 5,1962 5,1962 4,6904 5,4772 5,4772 4,7958 4,7958 4,7958 4,3589 4,1231 5 4,1231 5,1962 5 5 5,1962 3,1623 4,5826 4,3589 4,1231 5 4,7958 0 Facts5,2915 4,8990 5,5678 4,3589 4,7958 5,1962 6,0828 6,2450 5 4,7958 4,7958 4,7958 5 5 4,7958 5,3852 5,5678 6,5574 6,5574 6,0828 6,4031 6,2450 5,5678 6,2450 6,4031 5,9161 5 5 5,3852 5,5678 5,5678 5,3852 5 4,5826 5,5678 4,3589 6,0828 6,0828 6,2450 5,5678 5,7446 6,0828 6,2450 6,2450 5 5 4,7958 5,7446 5,3852 4,5826 4,1231 4,5826 5,7446 5,3852 5,1962 5,1962 4,7958 5,7446 5,9161 7,1414 6,0828 6,0828 6,4031 6,5574 6,2450 5,0990 4,2426 4,8990 5,1962 4,7958 4,3589 5,3852 5,3852 6,7082 6,0828 6,5574 6,4031 6,0828 6,1644 5,2915 4,8990 5,5678 5,7446 5,9161 5,3852 5 5,1962 5,3852 5,7446 5,9161 6,4031 6,5574 5,2915 5,3852 5,7446 5,1962 5,3852 5,1962 5,2915 0 4 5 4,5826 4,7958 5 5,7446 6,0828 5 4,5826 5 5,3852 5 5 4,7958 5,3852 5 6,4031 6,2450 5,7446 6,4031 6,2450 5,5678 6,0828 6,2450 5,9161 5 5 5 5,1962 5,5678 5 5 4,3589 5,5678 4,3589 5,9161 5,9161 5,5678 5,3852 5,5678 6,0828 6,2450 6,0828 4,5826 4,1231 5 5,3852 5,1962 4,7958 4,5826 4,5826 5,5678 5,5678 5,1962 5 4,5826 5,7446 5,5678 7 6,2450 5,9161 6,2450 6,4031 5,9161 4,6904 5,2915 4,8990 5,9161 5,5678 5 5,5678 5,3852 6,5574 6,0828 6,4031 6,2450 5,9161 6 5,4772 4,6904 6,0828 5,9161 5,9161 5,1962 5,1962 5,7446 5,3852 5,9161 5,7446 6,2450 6,2450 4,8990 5,5678 5,3852 5,3852 5,9161 5,7446 4,8990 4 0 PX88_neu PX82_neu PX71_neu PX7_neu frei_B frei_A PX97 PX96 PX95 PX94 PX93 PX92 PX91 PX89 PX87 PX86 PX85 PX84 PX83 PX81 PX79 PX78 PX77 PX76 PX75 PX74 PX73 PX72 PX69 PX68 PX67 PX66 PX65 PX64 PX63 PX62 PX61 PX59 PX58 PX57 PX56 PX55 PX54 PX53 PX52 PX51 PX49 PX48 PX47 PX46 PX45 PX44 PX43 PX42 PX41 PX39 PX38 PX37 PX36 PX35 PX34 PX33 PX32 PX31 PX29 PX28 PX27 PX26 PX25 PX24 PX23 PX22 PX21 PX19 PX18 PX17 PX16 PX15 PX14 PX13 PX12 PX11 PX9 PX8 PX6 PX5 PX4 PX3 PX2 PX1 PX9 PX8 PX7 PX6 PX5 PX4 PX3 PX2 PX1

Bezeichnung Bezeichnung Wichtigkeithoch1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Wichtigkeithoch Wichtigkeitnormal 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Wichtigkeitnormal Generation1 1 1 1 1 1 1 1 Generation1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Generation2 www.cemm.at Generation2 Generation3 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Generation3 Generation4 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Generation4 Generation5 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Generation5 1 1 1 1 1 1 1 Generation6 1 1 1 1 1 1 1 Generation6 Generation7 1 1 1 1 1 1 Generation7 Generationkeine1 1 Generationkeine BruderpaarBruder_PX35 1 1 BruderpaarBruder_PX35 BruderpaarBruder_PX42 1 1 BruderpaarBruder_PX42 BruderpaarBruder_PX46 1 1 BruderpaarBruder_PX46 BruderpaarBruder_PX8 1 1 BruderpaarBruder_PX8 BruderpaarBruder_PX81 1 1 BruderpaarBruder_PX81 BruderpaarBruder_PX89 1 1 BruderpaarBruder_PX89 BruderpaarBruder_PX92 1 1 BruderpaarBruder_PX92 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Bruderpaarnein1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Bruderpaarnein AehnlichkeitAehnlich_PX14 1 1 AehnlichkeitAehnlich_PX14 1 AehnlichkeitAehnlich_PX29 1 AehnlichkeitAehnlich_PX29 AehnlichkeitAehnlich_PX3 1 1 AehnlichkeitAehnlich_PX3 1 AehnlichkeitAehnlich_PX32 1 AehnlichkeitAehnlich_PX32 1 AehnlichkeitAehnlich_PX34 1 AehnlichkeitAehnlich_PX34 1 AehnlichkeitAehnlich_PX41 1 1 1 AehnlichkeitAehnlich_PX41 1 AehnlichkeitAehnlich_PX431 AehnlichkeitAehnlich_PX43 1 AehnlichkeitAehnlich_PX441 AehnlichkeitAehnlich_PX44 AehnlichkeitAehnlich_PX45 1 1 AehnlichkeitAehnlich_PX45 AehnlichkeitAehnlich_PX46 1 1 1 1 AehnlichkeitAehnlich_PX46 AehnlichkeitAehnlich_PX47 1 1 1 AehnlichkeitAehnlich_PX47 AehnlichkeitAehnlich_PX53 1 1 1 1 AehnlichkeitAehnlich_PX53 AehnlichkeitAehnlich_PX54 1 1 AehnlichkeitAehnlich_PX54 AehnlichkeitAehnlich_PX58 1 1 AehnlichkeitAehnlich_PX58 AehnlichkeitAehnlich_PX63 1 1 1 AehnlichkeitAehnlich_PX63 AehnlichkeitAehnlich_PX73 1 1 AehnlichkeitAehnlich_PX73 AehnlichkeitAehnlich_PX771 1 1 AehnlichkeitAehnlich_PX77 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Aehnlichkeitnein 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Aehnlichkeitnein 1 1 1 Groessegross 1 1 1 1 1 1 1 1 1 1 1 1 1 Groessegross Groesseklein 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Groesseklein Groessemittel 1 1 1 1 1 1 1 1 1 1 Groessemittel Groesseriesig1 1 1 1 Groesseriesig Haptikhart1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Haptikhart Haptikweich 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Haptikweich Position_allgemeinhaengt1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Position_allgemeinhaengt Position_allgemeinsteht1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Position_allgemeinsteht Position_detailhaengt_mit_Abstand1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Position_detailhaengt_mit_Abstand Position_detailhaengt_ohne_Abstand1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Position_detailhaengt_ohne_Abstand Position_detailsteht1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Position_detailsteht MaterialBeton 1 1 1 1 MaterialBeton MaterialGips 1 1 1 1 1 1 1 1 1 1 1 1 1 MaterialGips MaterialKunstleder 1 1 1 1 1 1 MaterialKunstleder MaterialPapierpaste 1 1 1 1 MaterialPapierpaste MaterialPaste1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 MaterialPaste MaterialPlastik 1 1 1 1 1 MaterialPlastik MaterialPolyester1 1 MaterialPolyester MaterialSilikon 1 1 1 1 1 1 1 1 1 1 MaterialSilikon Aufbauabgegossen 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Aufbauabgegossen Aufbaugebaut1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Aufbaugebaut Aufbaugenaeht 1 1 1 1 1 1 1 1 1 1 1 Aufbaugenaeht Aufbaulaminiert 1 Aufbaulaminiert Aufbau_detailabgegossen 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Aufbau_detailabgegossen Aufbau_detailgebaut1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Aufbau_detailgebaut Aufbau_detailgebaut_gefuellt 1 Aufbau_detailgebaut_gefuellt Aufbau_detailgenaeht_gefuellt 1 1 1 1 Aufbau_detailgenaeht_gefuellt Aufbau_detailgenaeht_hohl 1 1 1 1 1 1 1 Aufbau_detailgenaeht_hohl Aufbau_detaillaminiert_gefuellt 1 Aufbau_detaillaminiert_gefuellt Farbeblau 1 1 1 1 1 1 1 1 Farbeblau Farbebunt 1 Farbebunt FarbeFarbe_X 1 1 FarbeFarbe_X Farbegelb 1 1 1 1 1 1 1 Farbegelb Farbegrau 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Farbegrau Farbegruen 1 Farbegruen Farbegrün 1 Farbegrün Farbehellgruen 1 Farbehellgruen Farbemilch 1 1 Farbemilch Farbeorange.rot1 1 1 1 1 1 1 1 Farbeorange.rot Farberosa 1 Farberosa Farberot 1 1 Farberot Farbeschwarz 1 1 1 1 1 Farbeschwarz Farbeunbekannt 1 1 1 1 1 Farbeunbekannt Farbeweiss1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Farbeweiss Farbbasisfabric 1 1 1 1 1 1 1 1 1 1 1 1 Farbbasisfabric FarbbasisFarbauftrag1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 FarbbasisFarbauftrag FarbbasisMaterialfarbe 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 FarbbasisMaterialfarbe FarbbasisMetallbeine 1 1 1 1 FarbbasisMetallbeine FarbbasisPU.gruen 1 1 FarbbasisPU.gruen FarbbasisSilikon.gruen 1 FarbbasisSilikon.gruen Farbbasisunbekannt 1 1 1 1 Farbbasisunbekannt Farbkombinationblau.orange 1 1 Farbkombinationblau.orange Farbkombinationgelb.weiss 1 1 Farbkombinationgelb.weiss Farbkombinationgrau.gruen 1 1 Farbkombinationgrau.gruen Farbkombinationgrau.milch 1 Farbkombinationgrau.milch Farbkombinationgrau.weiss 1 Farbkombinationgrau.weiss Farbkombinationnein1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Farbkombinationnein Farbkombinationweiss.milch 1 1 1 Farbkombinationweiss.milch Zweites_MaterialHolzkiste 1 1 Zweites_MaterialHolzkiste Zweites_Materialnein1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Zweites_Materialnein Zweites_MaterialPlexiglas 1 1 1 Zweites_MaterialPlexiglas Zweites_MaterialPVC.Folie1 Zweites_MaterialPVC.Folie Einsatz_allgemeineinfach1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Einsatz_allgemeineinfach Einsatz_allgemeinnein1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Einsatz_allgemeinnein Einsatz_detail1Einsatz_Ausguss 1 1 1 1 1 Einsatz_detail1Einsatz_Ausguss Einsatz_detail1Einsatz_Glaslinse 1 1 Einsatz_detail1Einsatz_Glaslinse Einsatz_detail1Einsatz_M1 1 Einsatz_detail1Einsatz_M1 Einsatz_detail1Einsatz_M2 1 Einsatz_detail1Einsatz_M2 Einsatz_detail1Einsatz_M3 1 Einsatz_detail1Einsatz_M3 Einsatz_detail1Einsatz_M4 1 Einsatz_detail1Einsatz_M4 Einsatz_detail1Einsatz_Noppen 1 1 Einsatz_detail1Einsatz_Noppen Einsatz_detail1Einsatz_Schlauch 1 1 Einsatz_detail1Einsatz_Schlauch Einsatz_detail1Einsatz_Staender 1 1 Einsatz_detail1Einsatz_Staender Einsatz_detail1Einsatz_Ventil1 1 1 1 Einsatz_detail1Einsatz_Ventil Einsatz_detail1nein1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Einsatz_detail1nein Einsatz_detail2Einsatz_Glas 1 1 Einsatz_detail2Einsatz_Glas Einsatz_detail2Einsatz_Metall1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Einsatz_detail2Einsatz_Metall Einsatz_detail2Einsatz_Mutation 1 1 1 1 Einsatz_detail2Einsatz_Mutation Einsatz_detail2Einsatz_NA 1 Einsatz_detail2Einsatz_NA Einsatz_detail2Einsatz_Plastik 1 1 1 Einsatz_detail2Einsatz_Plastik Einsatz_detail2Einsatz_Schaumgummi 1 1 Einsatz_detail2Einsatz_Schaumgummi Einsatz_detail2nein1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Einsatz_detail2nein IronieIronie1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 IronieIronie Ironienein1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Ironienein Biomorphbiomorph 1 1 1 1 1 1 1 1 1 1 Biomorphbiomorph Biomorphnein1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Biomorphnein Biomorph_detailbiomorph_andere 1 1 1 1 Biomorph_detailbiomorph_andere Biomorph_detailbiomorph_tailliert 1 1 1 1 1 1 Biomorph_detailbiomorph_tailliert Biomorph_detailnein1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Biomorph_detailnein Schnorchel_allgemeinnein1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Schnorchel_allgemeinnein Schnorchel_allgemeinSchorchel 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Schnorchel_allgemeinSchorchel Schnorchel_detail1nein1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Schnorchel_detail1nein Schnorchel_detail1Schnorchel_schmal 1 1 1 1 1 1 1 1 1 Schnorchel_detail1Schnorchel_schmal Schnorchel_detail1Schnorchel_Variation 1 1 1 1 1 1 1 1 Schnorchel_detail1Schnorchel_Variation Schnorchel_detail2nein1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Schnorchel_detail2nein Schnorchel_detail2Schnorchel_Aufsatz 1 1 Schnorchel_detail2Schnorchel_Aufsatz Schnorchel_detail2Schnorchel_Metall 1 Schnorchel_detail2Schnorchel_Metall Schnorchel_detail2Schnorchel_rund 1 1 1 1 Schnorchel_detail2Schnorchel_rund Schnorchel_detail2Schnorchel_schmal 1 1 1 1 1 1 1 1 1 Schnorchel_detail2Schnorchel_schmal DUO_GruppeDuo 1 1 1 1 1 1 1 1 1 1 DUO_GruppeDuo DUO_GruppeGruppe1 1 1 1 1 1 DUO_GruppeGruppe DUO_Gruppesingle1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 DUO_Gruppesingle Oeffnung_allgemeingeschlossene_Form1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Oeffnung_allgemeingeschlossene_Form Oeffnung_allgemeinHuelle 1 1 1 1 1 1 1 1 1 1 1 1 Oeffnung_allgemeinHuelle Oeffnung_allgemeinMutationA 1 Oeffnung_allgemeinMutationA Oeffnung_allgemeinMutationB 1 Oeffnung_allgemeinMutationB Oeffnung_detailgeschlossene_Form1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Oeffnung_detailgeschlossene_Form Oeffnung_detailHuelle_gefuellt 1 1 1 1 1 Oeffnung_detailHuelle_gefuellt Oeffnung_detailHuelle_leer 1 1 1 1 1 1 1 Oeffnung_detailHuelle_leer Oeffnung_detailMutationA 1 Oeffnung_detailMutationA Oeffnung_detailMutationB 1 Oeffnung_detailMutationB Formmerkmal2_Spoiler 1 1 1 1 Formmerkmal2_Spoiler FormmerkmalHoehle 1 1 FormmerkmalHoehle FormmerkmalKombination 1 FormmerkmalKombination FormmerkmalLoch 1 1 1 1 1 FormmerkmalLoch Formmerkmalmittiger_Einsatz1 1 1 1 1 1 1 1 1 1 Formmerkmalmittiger_Einsatz Formmerkmalnein1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Formmerkmalnein FormmerkmalVertiefung 1 1 1 1 1 1 1 FormmerkmalVertiefung HalbkugelHalbkugel 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 HalbkugelHalbkugel Halbkugelnein1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Halbkugelnein Gereihteinfach 1 1 1 1 1 1 1 1 1 1 Gereihteinfach Gereihtgereiht 1 1 1 1 1 Gereihtgereiht Gereihtnein1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Gereihtnein Konvexkonvex 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Konvexkonvex Konvexnein1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Konvexnein Konkavkonkav 1 1 1 1 Konkavkonkav Konkavnein1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Konkavnein Voluminoesflach1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Voluminoesflach Voluminoesflach.voluminoes 1 1 1 1 1 1 1 1 1 1 1 1 1 Voluminoesflach.voluminoes Voluminoesvoluminoes1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Voluminoesvoluminoes Oberflaecheglatt1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Oberflaecheglatt Oberflaechestruktur 1 1 1 1 1 1 1 1 1 Oberflaechestruktur StrukturMuta1 1 StrukturMuta1 StrukturMuta2 1 StrukturMuta2 StrukturMuta3 1 StrukturMuta3 Strukturnein1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Strukturnein StrukturNoppen 1 1 1 1 StrukturNoppen StrukturRillen 1 1 StrukturRillen Sockelnein1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Sockelnein SockelSockel 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 SockelSockel BeineBeine1 1 1 1 1 1 1 1 1 BeineBeine Beinenein1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Beinenein Zusatztitelja1 1 1 1 1 1 1 1 1 1 Zusatztitelja Zusatztitelnein 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Zusatztitelnein