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Research Report 2009 Ce — MM — — Research Report 2009 Ce — M —M — Research Report 2009 3 3 Director’s Intro — The Austrian Academy of > p. 8—10 Sciences — Research at CeMM — Prudence and > p. 11—17 > p. 20—21 Vigilance — Justice and Wisdom — Faith > p. 22—29 > p. 32—39 and Constancy — Liberality — CeMM Sabbatical > p. 42—51 > p. 54—61 Visiting Scientist — CeMM/MUV Interdisciplinary > p. 64—65 PostDocs — CeMM PostDocs — CeMM PhD program — > p. 66—68 > p. 69—72 > p. 73—76 CeMM Principal Investigators — CeMM Retreat — > p. 77—85 > p. 86—87 CeMM Landsteiner Lecture — CeMM Scientific > p. 88—89 Advisory Board — CeMM Christmas Party — CeMM > p. 90—91 > p. 92—93 Building — CeMM Directory — CeMM Publications > p. 96—97 > p. 98—101 > p. 102—103 2009 — CeMM Facts and Figures — CeMM Health > p. 104—107 Research Bond — CeMM Sponsoring Info — Glossary > p. 108—109 > p. 110—111 of Molecular Medicine — Acknowledgements > p. 112—113 > p. 116 What a critical year! We almost completed The Scientific Advisory Board, fearlessly cap- As in the previous years, CeMM has profited construction of our new building, to be ready to tained by Prof. David Livingston of the Dana- tremendously of the training of 22 PhD students, move in late spring 2010. We witnessed an Farber Cancer Research Institute and Harvard who participate in several PhD programs hosted CeMM explosion of support on the whole concept of University, visited us in November. One of by the MUV. They form the foundations of bridging basic molecular and post-genomic the recommendations expressed at the previous CeMM’s trans-disciplinary knowledge base and research with the chances and difficulties of the meeting was to push towards medicine. They are a constant source of creativity. As of 2010, Research clinical realm. It is becoming more and more were happy about the progress obtained and we will also start a postdoctoral program aimed obvious that the revolutionary molecular knowl- encouraged us to intensify the thrust. Our col- at offering the same degree of organized edge on human individuals and on particular laboration with the Medical University of Vienna medicine-science cross-training to postdoc fel- diseases will drastically change medicine. Most (MUV), that sort of surrounds us like a womb, lows. In 2009, we have had numerous attractive Report importantly, it may well change our basic philo- is of course critical for this and many events international speakers, offering to the entire sophical perception on human individuality. We and initiatives in 2009 contributed to this goal. MUV campus at the General Hospital, another start evaluating in great detail not only the body We were very happy that CeMM Principal chance to meet and discuss with CeMM members plan (genome) as it is modified by our personal Inves tigator Christoph Binder became Professor and with the speakers. CeMM’s Landsteiner 2009 history with our environment (epi-genome), of Atherosclerosis Research at the Medical Uni- lecture, held by Dr. Vishva Dixit of Genentech versity and congratulate him. His dual appoint- has again been a highlight for the community. Introduction by Giulio Superti-Furga but also how this plan, by being relentlessly exe- cuted, results in the variety of molecular and ment with the Department of Laboratory Probably the most important event of 2009 was cellular networks that make us unique as individ- Medicine is, similar to Sylvia Knapp’s dual affilia- the search for new Principal Investigators, oper- uals. Diseases affect these networks by putting tion with the Department of Medicine I, Division ated with the help of colleagues from the MUV, them out of balance. In essence, at CeMM we of Infectious Diseases and Tropical Medicine, the Vienna Biocenter and the Universities of characterize these fundamental molecular net- one of the vital umbilical cords that link CeMM Graz and Innsbruck. We had 184 applicants, works, look at their pathological malformations to the Medical University. We are indebted to many of which were excellent. Scientific achieve- and develop ideas on how to restore them. Prof. Oswald Wagner and Prof. Christoph Zielin- ments and vision, but also strategic fit with ski who represent the pillars of this collaborative CeMM’s focus on innate immunity, cancer, and Did we make enough progress this year? I believe set-up. CeMM has also profited very much vascular biology, were the important selection we did. The young Principal Investigators from the interdisciplinary fellows Stephan Blüml criteria. We will present the new Principal Inves- were successful in establishing their laboratories, and Viola Bergdorff, who, working in both tigators in next year’s report, but I would like publishing their initial findings and obtaining insti tutions, CeMM and the Medical University, to already thank everybody involved in the long additional funding from grants. Sebastian Nijman have contributed to enhance the flow of cultural hiring process. obtained two large grants and the “Wiener exchange. For this, we are grateful to Prof. Josef Zukunftspreis” (Vienna Prize for the Future), Smolen and Prof. Stephan Wagner for these How to move towards therapy? Principal thus confirming the appropriateness of CeMM interesting joint projects. Investigator Christoph Binder is making to bet on very young, internationally recruited, important progress towards the identification scientists. CeMM published important papers In the spirit of enhancing medical knowledge at of so-called “natural antibodies” that could be in cancer genetics and innate immunity, includ- CeMM it has been a privilege and also thrilling exploited therapeutically to treat or prevent ing the identification of a gene form that increases to host Prof. Eric Haura, Director of the Lung cardiovascular disease. 2009 was the year where the likelihood of a blood cancer and the identifi- Comprehensive Research Center of the Lee Moffitt ideas on combination therapy came of age at cation of a protein fighting infections. We also Cancer and Research Center in Florida, U.S.A, CeMM, both from a theoretical point of view proposed a new experimental therapy for acute for a sabbatical period in the director’s laboratory. (including interesting discussions with visitor lung injury and pneumonia and published a Eric’s experimental enthusiasm, personal drive Joe Lehár), from an experimental point of warning paper on the use of digitalis-like drugs in and patient-oriented perspective had an inspira- view (for example with Principal Investigator cancer treatment. This shows that our transla- tional effect on the laboratory and resulted in a Sebastian Nijman’s search for cancer vulner- tional-medical vocation is indeed becoming more few interesting successful studies on systems- abilities) and also from a therapeutic perspective evident. Most importantly, the organization has level approaches to lung cancer therapy. We are (where initial results from using different grown together through a nice and natural effort, hoping to establish an institutional tie with the kinase inhibitors are very encouraging at the with full awareness that special dedication had to “Moffitt” to continue the exciting collaboration. cellular level). go into forging relationships when groups are Along these lines are our efforts to use proteom- geographically separated. To all CeMM scientists ics as a discovery tool in a clinical setting. We and administration personnel goes our apprecia- have started a large proteomics-based collabora- tion and gratitude. Thank you! tion with the Department of Ophthalmology, led by Prof. Ursula Schmidt-Erfurt, to obtain a molecular characterization of the content of ocu- lar fluids in healthy individuals as well as in patients with the most threatening and abundant eye disorders. Giulio Superti-Furga, CeMM Scientific Director If you were wondering how the perspective of this photograph in front of the academy building came about: Photographer Michale Sazel and I were allowed to jump on the stage of a tow-away truck that was idle in front of the building! Ce — M —M — Research Report 2009 Ce — M —M — Research Report 2009 10 11 Without doubt, robust biological and patho- Finally, we again include our “CeMM Health logical systems are more easily made vulnerable Research Bond” to highlight our pact with by simultaneous attacks. As part of the necessary society. We envision a society that is increasingly toolbox, we have started gaining access to a aware of the opportunities that the ongoing The Statues chemical biology platform, partially financed biomedical revolution is offering and that gives by a grant of the GenAU program (Genome us input and feedback, and a society that is Austria, BMWF) respectfully called PLACEBO cheering on the sidelines for CeMM’s team of in the Academy (for Platform Austria for Chemical Biology) that mostly young researchers and that is willing links chemistry, pharmacology and disease biol- to support it, also financially. Awareness about Interview with Prof. Artur Rosenauer ogy groups across Austria to do focused chemical health and research can always be improved. by Prof. Giulio Superti-Furga screens on interesting assays and chemical CeMM wishes for a society that is serious about proteomics to identify targets. The name makes fighting infections, cancer and deaths from it clear that chemistry is used as a research tool, cardiovascular disease. In return, we promise but of course we envisage insights that can be our most serious engagement, fortified by the exploited therapeutically. PLACEBO is part of virtues mentioned above. a European network of chemical biology labora- tories called EU-OPENSCREEN that is seeking This is number three in the “Blue Books” series infrastructure funds from the European Union. that symbolize the research lab notebooks that we use daily. As in the past, you hold in your To structure this year’s report we have chosen hand the testimonial of our work. A very long to refer to the privilege of being associated with list of people that we wish to thank is at the end the Austrian Academy of Sciences.