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Research Report 2010 Research Report2010 www.cemm.at Research Report 2010 Research Report 2010 Director’s Intro — Research at CeMM — p. 6—9 p. 10—71 CeMM Principal Investigators — CeMM PhD p. 74—83 Program — CeMM as Spring board for Careers — p. 86—88 p. 89—91 CeMM Landsteiner Lecture — CeMM Constantin p. 94—97 Spiegelfeld Lecture — CeMMinar Series ­ — p. 98—101 p. 102—103 CeMM Retreat — CeMM Social Activities – CeMM p. 106—107 p. 108—111 Art Façade — CeMM Directory — CeMM Publications p. 114—121 p. 124—125 2010 — CeMM Facts and Figures — Sponsor the p. 128—129 p. 132—135 CeMM Brain Lounge — Acknowledgements — p. 136—137 p. 140—141 How to reach CeMM p. 142 Previous page: Level 04, Room 04.205 Functional Genomics Each and every CeMM member is crammed into one laboratory to symbolize many functions and talents superimposed and also to remember the crowded times in the Vienna Competence Center laboratories located in Lazarettgasse 19, where CeMM HQ were located until August 2010. Last year I began the introduction to the 2009 The celebration of the opening of the façade in Thus, CeMM trains young researchers that are research report with “What a year!”. So how then February set off the year magnificently. We had competitive at the highest international level! do I describe 2010: a period that saw CeMM finally the honour of the presence of Minister Beatrix In return, 2011 will see the beginning of three move into and occupy a tailor-made beautiful Karl in one of the first events she had attended new CeMM Principal Investigators (PIs): CeMM building in the middle of the country’s medical since taking up office, and holding on to a nice Kaan Boztug, from the University of Hannover action? Finally all scattered CeMM research groups glass of sparkling wine, despite the cold, every- Medical School, Joanna Loizou, from Cancer have come together under one roof! Apart body gladly drank with her to the new era that Research UK in London and Andreas Bergthaler, from the minor upheaval of the actual move, a the event seemed to herald. During the week from the Institute of Systems Biology in Seattle. Research logistical challenge per se, and the difficulties in July when the first people began to move into While this will not yet fill the new building associated with jump-starting the infrastructure the new building, we welcomed scientifically entirely, it will bring additional life to the 6th necessary to serve a demanding community of curious and very supportive Federal President and 7th floors and represent a phenomenal boost Report hard-working researchers, what an exhilarating Heinz Fischer and his wife Margaret Fischer. to CeMM research activities and competencies. and up-lifting year 2010 has been! Jokingly, we It might easily have been the sunniest day of We are also very happy to have secured as CeMM said that the five years preceding the move were the year, as the photographs remind us, and in Adjunct Principal Investigator Thijn Brummel- our “purgatory” years, testing our fitness and many respects the visit represented a particularly kamp, who in 2011 will join the Netherlands 2010 worthiness of the upgrade to first-class. Now that memorable and symbolic start of our newly Cancer Institute from the Whitehead Institute we can stand on our own terrace on the 8th floor, accommodated research activities. Once these of Biomedical Research in Cambridge, USA. with views of not only the medical campus but activities picked up pace, our main supporter At CeMM, Thijn will co-tutor PhD students and Introduction by Giulio Superti-Furga the entire city, below us a stunning work of art in and privileged partner, Minister Beatrix Karl, research projects. the form of a gigantic glass façade and above us, visited us again, this time inside the building. on a bright day, only some scattered fluffy clouds, We discussed the research program and societal Having our own building has also importantly we get paradisiacal emotions. mission of CeMM and, importantly, inaugurated increased our laboratory support facilities such the laboratory ironically named PLACEBO as health and safety and administration (finances The building is full of light, due to the large (Platform Austria for Chemical Biology), the and public relations). Moreover, in many respects windows and the “transparent” architecture gateway to some of our translational activities. we have simply become better organized. Denise of its creator, Ernst Kopper. Depending on the Stefan Kubicek, from Stuart Schreiber’s Barlow, a CeMM PI, has done a wonderful job weather, the beautiful façade reflects sky, clouds, laboratory at the Broad Institute of Harvard in starting a regular and exciting seminar series surrounding trees and buildings in a different University/MIT, had just joined CeMM to head (called CeMM-inars), weekly faculty lunches and, way, interweaving it with its own pattern and PLACEBO. Two events in the second half of together with Eva Schweng, is also supervising inside illumination, leading to an attractive ever- the year characterize the outreach part of CeMM’s common get-togethers and seminars with the changing appearance. When we come to work mission. In October the fine-looking lecture adjacent Center for Translational Medicine in the each morning, we still feel a bit incredulous that hall on the 8th floor housed the first Constantin Anna Spiegel building of the Medical University CeMM has such a superb home. The work of art Spiegelfeld Lecture on drug discovery and of Vienna. The enthusiasm and good will of by Peter Kogler, who designed the façade, imme- development with all its technical, commercial Medical University of Vienna Vice-Rector Oswald diately gained a lot of fans, not only among the and public health implications. George Poste, Wagner and colleague Hans Wojta were critical fifty plus sponsors who each contributed to a a towering figure in the field, inaugurated the for creating an inclusive and collaborative spirit “section” and whom I would like to thank here lecture series with a “big bang” sort of talk that between us. Mischa Pilz and his IT team have set again, but also among students, campus visitors created a lot of resonance. In December we had up large flat screens in the entrance hall on the and even construction workers. Here is an the CeMM Science Day where research projects 3rd and 8th floors to advertise all events. I take example for illustration: on the day the last façade in the institute were presented to the public. the occasion to welcome and thank everybody, piece was put into place, the artist and I visited The event was attended by the President of the especially Gabriel O’Riordain. That we are getting the building, which was at that time unfinished, Austrian Academy of Sciences and was very well better organized also became apparent on the with only concrete floors. We met a woman received so we plan to repeat it annually. The Karl occasion of a few social events that surprised us working on the first floor tiles in a room close Landsteiner lecture, presented by the Howard on account of the creativity and intensity that to the façade window and asked her sceptically Hughes Medical Institute Investigator Helen accompanied them. After a lukewarm after- what it was all about. Not knowing who we were, Hobbs in the great hall of the Academy building, barbeque party in the summer I had frankly she expressed her views frankly and produced was once again a resounding success. wondered if CeMM, as a group, would be able to a spontaneous, funny and charming approval. party at all. I was soon proven to be completely We knew then it was going to be a success. An important milestone in 2010 was the wrong by a phantasmagorical Halloween party graduation of the first wave of CeMM PhD organized by the CeMM PhD students, who students (Roland Jäger, Ana Zivkovic and Irena decorated the building and themselves, as well Vlatkovic) as well as the start of our third PhD as the entire CeMM community. Scientific programme. Also, we are exceptionally proud advisory board (SAB) member Hidde Ploegh, that Post-doctoral fellow Oliver Hantschel, from of the Whitehead Institute in the USA, happened my own group, accepted a position as Assistant to be in town and willingly dropped by, and was Professor in a new department headed by the immediately “transylvanized” and completely American molecular cancer research pioneer drawn into the party action. He left enthusiastic: Doug Hanahan, which is affiliated with the “It was incredible, all SAB members should have cancer research foundation at the Swiss Federal experienced this!”. Institute of Technology (École Polytechnique Fédérale De Lausanne, EPFL) in Lausanne. Ce — M —M — Research Report 2010 6 7 An even larger party, enlarged to include partners and clinical trials, it turns out that CeMM has and families, was the Christmas get-together, produced the first and second most highly cited with games, performances and the exchange of papers of the last two years in the whole of presents from a large potluck heap. I am deeply Austria (Bürckstümmer et al, Nature Immunology thankful to all the people who contributed to 2009 and Olcaydu et al. Nature Genetics 2009). make CeMM a work hard/party hard place This is in all disciplines! While experts would within such a short time, for this is a critical caution that these results can be biased and may requisite of all successful research institutions look different in the future, it clearly tells us that I have experienced. So, how about our output? CeMM is on the right track! So young but already so clearly on the research map, and under sub- As the health activist and philanthropist Mary optimal conditions.
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