BavenoVII ADVANCED PROGRAMME ADVANCED CONSENSUS WORKSHOP PERSONALIZED CARE IN PORTAL HYPERTENSION Grand Hotel Dino | Baveno, Lake Maggiore, Italy October 29-30, 2021
PEDIATRIC RESEARCH MEETING Primary prophylaxis of variceal hemorrhage, complexities October 31, 2021 in the development of evidence-based approaches in pediatrics
www.baveno7.com BAVENO COOPERATION STEERING COMMITTEE
HONORARY PRESIDENT SCIENTIFIC SECRETARIES Roberto de Franchis, Milan (Italy) Thomas Reiberger Medical University of Vienna CHAIR Department of Internal Medicine III Div. of Gastroenterology & Hepatology , Bern (Switzerland) Jaime Bosch Vienna Hepatic Experimental Hemodynamic Lab
VICE-CHAIR Cristina Ripoll Guadalupe Garcia-Tsao, New Haven (USA) Martin Luther University of Halle-Wittenberg First Department of Internal Medicine Halle (Saale), Germany Juan G. Abraldes, Edmonton (UK) Agustin Albillos, Madrid (Spain) Annalisa Berzigotti, Bern (Switzerland) Gennaro D’Amico, Palermo (Italy) Andrea De Gottardi, Lugano (Switzerland) Alessandra Dell’Era, Milan (Italy) Juan Carlos Garcia-Pagàn, Barcelona (Spain) Joan Genescà, Barcelona (Spain) Aleksander Krag, Odense (Denmark) Wim Laleman, Leuven (Belgium) Vincenzo La Mura, Milan (Italy) Dominique Thabut, Paris (France) Jonel Trebicka, Frankfurt (Germany) Emmanouil Tsochatzis, London (UK) Dominique Valla, Paris (France) Candid Villanueva, Barcelona (Spain)
2 SUPPORTED BY
European Association for the Study of the Liver
American Association for the Study of Liver Diseases
Asian Pacific Association for the Study of the Liver
ENDORSED BY
Associazione Italiana per lo Studio del Fegato
Japanese Society of Hepatology
3 FACULTY
Juan G. Abraldes - Edmonton, Canada Agustin Albillos - Madrid, Spain Salvador Augustin - Barcelona, Spain Anna Baiges - Barcelona, Spain Jasmohan Bajaj - Richmond, Usa Rafael Bañares - Madrid, Spain Marta Barrufet - Barcelona, Spain Annalisa Berzigotti - Bern, Switzerland Jaime Bosch - Bern, Switzerland Christophe Bureau - Toulouse, France Vincenza Calvaruso - Palermo, Italy Andrés Càrdenas - Barcelona, Spain Gennaro D’Amico - Palermo, Italy Roberto de Franchis - Milan, Italy Andrea De Gottardi - Lugano, Switzerland Alessandra Dell’Era - Milan, Italy Angels Escorsell - Barcelona, Spain Jonathan Fallowfield - Edinburgh, United Kingdom Hector Ferral - Evanston, Usa Sven Francque - Antwerp, Belgium Ron Gaba - Chicago, Usa Juan Carlos Garcia Pagàn - Barcelona, Spain Guadalupe Garcia-Tsao - New Haven, Usa Joan Genescà - Barcelona, Spain Susana Gomes Rodrigues - Bern, Switzerland Jordi Gracia - Barcelona, Spain Guohong Han - Xi’an, China Ziv J. Haskal - Charlotteville, Usa Virginia Hernandez-Gea - Barcelona, Spain Jidong Jia - Bejing, China Jean Jacques Kiladjian - Paris, France Aleksander Krag - Odense, Denmark Vincenzo La Mura - Milan, Italy
4 FACULTY
Wim Laleman - Leuven, Belgium Sabela Lens - Barcelona, Spain Xuefeng Luo - Chengdu, China Mattias Mandorfer - Vienna, Austria Sarwa Darwish Murad - Rotterdam, The Netherlands Valerie Paradis - Clichy, France David Patch - London, United Kingdom Salvatore Piano - Padua, Italy Massimo Pinzani - London, United Kingdom Aurelie Plessier - Clichy, France Massimo Primignani - Milan, Italy Bogdan Procopet - Cluj-Napoca, Romania Pierre Emmanuel Rautou - Paris, France Thomas Reiberger - Vienna, Austria Cristina Ripoll - Halle, Germany Marika Rudler - Paris, France Shiv K. Sarin - New Delhi, India Filippo Schepis - Modena, Italy Marco Senzolo - Padua, Italy Vijay Shah - Rochester, Usa Puneeta Tandon - Edmonton, Canada Luis Tellez - Madrid, Spain Dominique Thabut - Paris, France Maja Thiele - Odense, Denmark Jonel Trebicka - Frankfurt, Germany Dhiraj Tripathi - Birmingham, United Kingdom Emmanouil A. Tsochatzis - London, United Kingdom Laura Turco - Modena, Italy Dominique Valla - Clichy, France Candid Villanueva - Barcelona, Spain Ian Wanless - Halifax, Canada Hitoshi Yoshiji - Kashihara, Japan
5 WELCOME ADDRESS
Baveno VII is a sequel of the Baveno I-VI Workshops, which were held every 5 years from 1990 to 2015. All the previous Workshops were successful, as proven by more than 3000 citations of the Workshop reports in the medical literature.
After Baveno VI, important advances have been made in understanding the pathophysiology of portal hypertension, as well as in developing new treatments and new strategies for the management of advanced cirrhosis and portal hypertension. For these reasons, we thought that the time had come to organize a seventh Baveno Workshop.
As for the previous editions, the aim of the Baveno VII Workshop is twofold: first, to review and put into perspective the changes in diagnostic and therapeutic strategies that have occurred in the past 5 years in the field of portal hypertension.
Second, to continue the effort - which had begun in Baveno I thirty years ago - of producing updated definitions and guidelines aimed at improving the management of patients as well as the quality of our future studies.
The Workshop will begin with a brief introduction, followed by three lectures, the first one on the new concept of risk stratification, the second one on competing risks and stages in cirrhosis, and the third on life style and genetic modifiers of progression of compensated advanced chronic liver disease.
6 WELCOME ADDRESS
The structure of the Workshop is similar to that of the previous ones - there will be 4 sessions: each divided into 2-3 parts. The first session will concern the evaluation and risk stratification of patients with cirrhosis, focusing on the HVPG as a gold standard and on non-invasive surrogates for the diagnosis of compensated advanced chronic liver disease, clinically significant portal hypertension and varices. The second session, dedicated to the new clinical scenarios will be divided into three parts. The first one will include four introductory lectures on progression and regression of cirrhosis; the second one will analyze the impact of etiological therapy for cirrhosis, and the third one will deal with the impact of non-etiological novel therapies in cirrhosis. The third session will deal with the different clinical settings and will also be divided into three parts: the first one will be devoted to the prevention of (first) decompensation, the second one to acute variceal hemorrhage, and the third one to the prevention of further decompensation.
The fourth session will be devoted to vascular liver diseases in cirrhosis, and will consist of two parts: the first one on diagnosis and staging, and the second one to treatment. According to the Baveno tradition, at the end of each session, updated consensus statements on the topic of the session will be presented and discussed by the Panels and the Audience.
Roberto de Franchis On behalf of the Baveno Cooperation Steering Committee
7 SCIENTIFIC PROGRAMME
FRIDAY OCTOBER 29
08.00 Welcome and introduction R. de Franchis (Milan) 08.10 LECTURE 1: New concept of risk stratification Speaker: J.G. Abraldes (Edmonton) 08.30 LECTURE 2: Clinical stages and ordinal outcomes in portal hypertension Speaker: G. D’Amico (Palermo) 08.50 LECTURE 3: Lifestyle and genetic modifiers of progression of Compensated Advanced Chronic Liver Disease (cACLD) Speaker: A. Berzigotti (Bern)
09.15-13.00 SESSION 1 EVALUATION AND RISK STRATIFICATION 09.15 PART 1: HVPG as a gold standard Chairpersons: J.C. Garcia-Pagàn (Barcelona), Z. Haskal (Charlotteville) Panelists: H. Ferral (Evanston), R. Gaba (Chicago), F. Schepis (Modena)
10.00 Coffee break and poster viewing
10.30 PART 2: Non-invasive surrogates for cACLD, CSPH, Varices Chairpersons: A. Berzigotti (Bern), J. Genescà (Barcelona) Panelists: J.G. Abraldes (Edmonton), S. Augustin (Barcelona) J. Fallowfield (Edinburgh), M. Thiele (Odense)
13.00-14.00 Lunch break
8 SCIENTIFIC PROGRAMME
FRIDAY OCTOBER 29 14.00-18.20 SESSION 2 NEW SCENARIOS PART 1: Progression and regression of cirrhosis Chairpersons: W. Laleman (Leuven), D. Patch (London) 14.00 PELS in progression. Can they regress? Speaker: I. Wanless (Halifax) 14.20 Fibrogenesis and regression of fibrosis Speaker: M. Pinzani (London) 14.40 Angiogenesis and progression of ACLD Speaker: V. Shah (Rochester) 15.00 Drugs to modify liver fibrosis progression and regression (preclinical and clinical studies) Speaker: J. Gracia (Barcelona) 15.20 PART 2: Impact of etiological therapy for cirrhosis Chairpersons: M. Mandorfer (Vienna), E. Tsochatzis (London) Panelists: S. Francque (Antwerp), J. Jia (Beijing) S. Lens (Barcelona), H. Yoshiji (Kashihara)
16.40 Coffee break and poster viewing
17.10 PART 3: Impact of non-etiological novel therapies in cirrhosis Chairpersons: A. Albillos (Madrid), J. Trebicka (Frankfurt) Panelists: J. Bajaj (Richmond), J. Gracia (Barcelona) A. Krag (Odense), W. Laleman (Leuven), V. Shah (Rochester)
9 SCIENTIFIC PROGRAMME
FRIDAY OCTOBER 29 18.20-19.30 SESSION 3 CLINICAL SETTINGS 18.20 PART 1: Preventing decompensation: review of current evidence Chairpersons: J. Bosch (Bern), C. Ripoll (Halle) Panelists: R. Bañares (Madrid), V. Calvaruso (Palermo), A. Dell’Era (Milan), S. Gomes Rodrigues (Bern), D. Tripathi (Birmingham), C. Villanueva (Barcelona)
10 SCIENTIFIC PROGRAMME
SATURDAY OCTOBER 30
07.30-08.30 Industry Sponsored Breakfast Symposium
SATURDAY OCTOBER 30 Baveno VII Workshop (continued)
08.40-13.40 SESSION 3 CLINICAL SETTINGS (CONTINUED) 08.40 PART 2: Acute variceal bleeding Chairpersons: V. Hernandez-Gea (Barcelona), D. Thabut (Paris) Panelists: A. Càrdenas (Barcelona), A. Escorsell (Barcelona) G. Han (Xi’an), X. Luo (Chengdu), D. Patch (London) B. Procopet (Cluj-Napoca), M. Rudler (Paris)
10.40 Coffee break and poster viewing
11.10 PART 3: Preventing further decompensation Chairpersons: G. Garcia-Tsao (New Haven), T. Reiberger (Vienna) Panelists: C. Bureau (Toulouse), G. D’Amico (Palermo), V. La Mura (Milan) S. Piano (Padua), P. Tandon (Edmonton), L. Turco (Modena)
13.40-14.40 Lunch Break
11 SCIENTIFIC PROGRAMME
SATURDAY OCTOBER 30 14.40-17.40 SESSION 4 VASCULAR LIVER DISORDERS 14.40 PART 1: Splanchnic Vein Thrombosis Chairpersons: S. Sarin (New Delhi), D. Valla (Clichy) Panelists: A. Baiges (Barcelona), M. Barrufet (Barcelona), J.J. Kiladjian (Paris) A. Plessier (Clichy), M. Primignani (Milan) 16.10 PART 2: Other issues in vascular liver disorders Chairpersons: A. De Gottardi(Lugano), P.E. Rautou (Paris) Panelists: S. Murad (Rotterdam), V. Paradis (Clichy) M. Senzolo (Padua), L. Tellez (Madrid) 17.40-17.50 Closing remarks R. de Franchis
12 PEDIATRIC RESEARCH WORKSHOP
SUNDAY OCTOBER 31 Primary prophylaxis of variceal hemorrhage, complexities in the development of evidence-based approaches in pediatrics
08.00-11.30 Introductory Session
08.00 Introduction and goals B.L. Shneider (Houston) 08.10 Morbidity and mortality of first variceal hemorrhage J. Molleston (Indianapolis) 08.40 Experiences with primary prophylaxis M. Duché (Paris) 09.10 Rationale for primary prophylaxis in adults R. de Franchis (Milan) 09.40 Complexity of a randomized clinical trial in pediatrics S.C. Ling (Toronto) 10.10 Introduction of a Pediatric Portal Hypertension Registry B. Shneider (Houston) 10.40 Open Discussion - Q&A
11.30 Lunch on your own
13 PEDIATRIC RESEARCH WORKSHOP
14.00-19.00 Research Plan Discussion
14.00 Introduction and goals B. Shneider (Houston) 14.10 Presentation of the First Variceal Hemorrhage Database J. Pimenta (Belo Horizonte) 14.40 Discussion of First Variceal Hemorrhage Database 15.30 Primary and pre-primary prophylaxis of variceal hemorrhage with the MesoRex Bypass and a MesoRex Bypass Registry R. Superina (Chicago) 16.10 Discussion of MesoRex Bypass Registry 16.40 Break 17.00 Presentation of the Primary Prophylaxis Database T. Grammatikopoulos (London) 17.30 Discussion of the Primary Prophylaxis Database 18.20 Concluding remarks J. Bosch (Berne) 18.30 Plans forward B. Shneider (Houston)
FACULTY
Jaime Bosch - Bern, Switzerland Roberto de Franchis - Milan, Italy Mathieu Duché - Paris, France Tassos Grammatikopoulos - London, United Kingdom Simon C. Ling - Toronto, Canada Jean P. Molleston - Indianapolis, USA Júlio R. Pimenta - Belo Horizonte, Brazil Benjamin L. Shneider - Houston, USA Riccardo Superina - Chicago, USA
14 INDUSTRY SPONSORED BREAKFAST SYMPOSIUM
SATURDAY OCTOBER 30 Controlled expansion tips. Where are we?
07.30 Breakfast
07.45-08.30 20 years of expertise with TIPS Historic overview and future outlook Chairman: T. Reiberger The history of the TIPS procedure, indications, patients and device evolution. Experience with the GORE® VIATORR® TIPS Endoprosthesis J. Bosch The future of small diameter TIPS. What tools do we have to better predict outcomes and minimize post TIPS complications? J. Trebicka
FACULTY
Jaime Bosch - Bern, Switzerland Thomas Reiberger - Vienna, Austria Jonel Trebicka - Frankfurt, Germany
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SCIENTIFIC INFORMATION POSTER EXHIBITION The accepted abstracts will be displayed as electronic posters in the Exhibition Area. The 2 best posters will be awarded at the end of the Workshop EUROPEAN CME ACCREDITATION An application will be made to the EACCME® for CME accreditation of this event. ITALIAN CME ACCREDITATION The Workshop has been assigned 17 CME Italian credits for Physicians. Certificates of granted credits will be sent by e-mail after the Workshop to those who have attended the whole Workshop and filled in all relevant documents.
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GENERAL INFORMATION WORKSHOP SITE Grand Hotel Dino Corso Garibaldi 20 28831 Baveno (VB), Italy HOW TO REACH THE WORKSHOP SITE by plane: 35 km from Milano Malpensa Airport 100 km from Milano Linate Airport by train: from Milano Centrale stop at Stresa (about 1 hour). Baveno is a few minutes by taxi from the train Station in Stresa. Connections with Milano Malpensa Airport: www.milanomalpensa.airport.com/en/from-to Connections with Milano Linate Airport: www.milanolinate.airport.com/en/from-to by car: Baveno can be reached from the highway “Milano-Laghi A8” (direction Gravellona Toce). From here highway “A26”, exit Baveno-Stresa. From the North: Baveno can be reached from the “Gotthard” or “Simplon” passes. OFFICIAL LANGUAGE English is the official language of the Workshop. No simultaneous translation willbe provided. ATTENDANCE CERTIFICATES Attendance Certificates will be made out upon request to all Participants at the end of the Workshop. LUNCH AND COFFEE BREAKS Lunch and coffee breaks will be served in the Workshop venue according to the programme.
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REGISTRATION AND HOTEL ACCOMMODATION REGISTRATION FEES (22% VAT included – vat is quoted according to the actual rate in force. All prices will be updated in case of legal changes in the applicable rate) • EXTENDED FULL REGISTRATION till December 18, 2020 € 1.000,00 • EXTENDED FULL REGISTRATION FOR YOUNG INVESTIGATORS till December 18, 2020 € 400,00 • LATE REGISTRATION after December 18, 2020 € 1.300,00 • LATE REGISTRATION FOR YOUNG INVESTIGATORS after December 18, 2020 € 600,00 • PEDIATRIC SYMPOSIUM € 150,00 * Young investigators must be under 35 years old and still in training at the time of the Workshop. Proof of age and training status is mandatory ** Registation in the Baveno VII Workshop is mandatory to register for the Pediatric Research Workshop To enquire about the opportunity to benefit of Educational Grants please contact the Organizing Secretariat at [email protected] The Registration fee includes: • Admission to scientific sessions • Entrance in the exhibition area • Workshop kit • Coffee Breaks and lunch according to the programme • Attendance Certificate HOTEL ACCOMMODATION Allotments of rooms have been reserved for the Workshop delegates: special rates are available in the selected hotels listed in the Registration and Hotel Accommodation Form HOW TO REGISTER IN THE WORKSHOP AND REQUEST HOTEL ACCOMMODATION Registration and hotel accommodation can be made online through the www.baveno7.com website or by completing the Registration and Hotel Accommodation Form and forwarding it with full payment to the Organizing Secretariat. Registration for the Workshop must be forwarded within October 1, 2021: after this date only on site registrations will be accepted. Hotel Accommodation must be requested within September 1, 2021: after this date the Organizing Secretariat will be unable to guarantee reservations, although every effort will be made to meet delegates’ requirements. All incoming requests will be managed on a “first come first served basis”. PAYMENT OF THE REGISTRATION FEE AND OF HOTEL ACCOMMODATION Online registration and hotel accommodation must be paid by credit card. In case of payment by bank transfer, delegates are requested to fill in the Registration and Hotel Accommodation Form and to send it together with the receipt of payment to the Organizing Secretariat. 18 CONSENSUS WORKSHOP PERSONALIZED CARE BavenoVIIBavenoIN PORTAL HYPERTENSION Grand Hotel Dino | Baveno,VII Lake Maggiore, Italy CONSENSUSOctober 29-30, WORKSHOP 2021 PERSONALIZED CARE IN PORTAL HYPERTENSION
Grand Hotel Dino | Baveno, Lake Maggiore, Italy October 29-30, 2021
Please complete this form and send it to the Organizing Secretariat ADB Eventi&Congressi (fax 0039-051-0959164 / e-mail [email protected]) REGISTRATION AND HOTEL Deadline for registration: October 1, 2021 after this date only on site registration will be possible ACCOMMODATION FORM Deadline for hotel accommodation: September 1, 2021
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REGISTRATION n € REGISTRATION FEES EXTENDED FULL REGISTRATION till December 18, 2020 1000,00 n EXTENDED FULL REGISTRATION FOR YOUNG INVESTIGATORS till December 18, 2020 € 400,00 (22% VAT included - vat is quoted € according to the actual rate in force. n LATE REGISTRATION after December 18, 2020 1.300,00 All prices will be updated in case of legal n LATE REGISTRATION FOR YOUNG INVESTIGATORS after December 18, 2020 € 600,00 changes in the applicable rate) n PEDIATRIC SYMPOSIUM € 150,00 * Young investigators must be under 35 years old and still in training at the time of the congress (October 29, 2021). Proof of age and training status is mandatory ** Registation in the Baveno VII Workshop is mandatory to register for the Pediatric Research Workshop HOTEL ACCOMMODATION HOTEL RATES - PLEASE MAKE YOUR HOTEL AND ROOM CHOICE ON THE LIST BELOW: All rates quoted are per room, per night and include breakfast, service, taxes and private facilities. Rates do not include local city tax, which will be charged directly in the hotel (€ 2,00 per night and per person in **** / € 1,30 per night per person in ***). *all prices quoted include 10% VAT- prices will be updated in case of legal vat applicable rate changes. All requests will be managed on a first come first served basis. Hotel accommodation must be requested within September 1, 2021: after this date the Organizing Secretariat will be unable to guarantee room availability, although every effort will be made to meet delegates’ requirements. Please note that hotel accommodation will not be effective until payment of the whole stay +€ 25,00 per room as processing fee has been received by the Organizing Secretariat.
HOTEL (B&B) HOTEL (B&B) Grand Hotel Dino**** n Double room single use € 160,00 Hotel Al Campanile*** n Double room single use € 110,00 Corso Garibaldi, 20 - Baveno (VB) n Double room € 180,00 Via Antonio Gramsci 3 - Baveno (VB) n Double room € 145,00 Hotel Splendid**** n Double room single use € 140,00 Str. Nazionale del Sempione, 12 n € Baveno (VB) Double room 160,00
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