Suppl. Table 1. Somatic single nucleotide substitution spectrum. Base Pre Pre PV1 PV1 PV2 PV2 substitution Number Frequency Number Frequency Number Frequency C>A at AC 1 0.93 2 1.44 1 0.79 C>A at CC 9 8.41 18 12.95 13 10.24 C>A at GC 2 1.87 4 2.88 6 4.72 C>A at TC 4 3.74 4 2.88 3 2.36 C>G at AC 0 0 1 0.72 1 0.79 C>G at CC 1 0.93 0 0 0 0 C>G at GC 0 0 0 0 1 0.79 C>G at TC 3 2.8 3 2.16 5 3.94 C>T at AC 3 2.8 5 3.6 6 4.72 C>T at CC 21 19.63 22 15.83 23 18.11 C>T at GC 7 6.54 6 4.32 8 6.3 C>T at TC 42 39.25 43 30.94 47 37.01 T>A at AT 0 0 1 0.72 0 0 T>A at CT 1 0.93 2 1.44 2 1.57 T>A at GT 1 0.93 1 0.72 1 0.79 T>A at TT 1 0.93 1 0.72 1 0.79 T>C at AT 5 4.67 10 7.19 2 1.57 T>C at CT 4 3.74 7 5.04 2 1.57 T>C at GT 0 0 6 4.32 1 0.79 T>C at TT 1 0.93 2 1.44 2 1.57 T>G at AT 0 0 0 0 0 0 T>G at CT 1 0.93 1 0.72 1 0.79 T>G at GT 0 0 0 0 0 0 T>G at TT 0 0 0 0 1 0.79 Suppl. Table 2. Somatic single nucleotide substitution frequencies. Position PRE mut. PV1 mut. PV2 mut. Variant Protein Polyphen2 Gene Chr Ref Alt (hg19) frequency frequency frequency classification Change classification ABCA4 chr1 94506881 C T 0.3174 0.3339 0.4076 Missense p.G1136R deleterious ACAD10 chr12 112167698 C T 0.3589 0.3199 0.4155 Silent p.I444I ADAM7 chr8 24350099 C A 0.0000 0.1305 0.0000 Silent p.P548P ADAMTS18 chr16 77325260 G T 0.0000 0.2877 0.0000 Missense p.P1102Q deleterious AIM1L chr1 26648727 G T 0.0411 0.0000 0.0000 Missense p.Q564K deleterious ALKBH8 chr11 107427696 C T 0.3086 0.3440 0.3818 Missense p.G55S neutral ANAPC4 chr4 25391826 T C 0.0000 0.0791 0.0000 Missense p.I195T deleterious AP1M2 chr19 10692467 C T 0.3373 0.3568 0.4225 Missense p.D119N deleterious APBA1 chr9 72071978 G T 0.0000 0.0126 0.0000 Silent p.A531A ARHGEF12 chr11 120317186 C T 0.3298 0.2840 0.3340 Missense p.P474S deleterious ATP2B4 chr1 203689832 C T 0.0318 0.2228 0.0000 Silent p.A854A BAT2 chr6 31600519 G A 0.3145 0.3078 0.3587 Missense p.G1357S none BCL11B chr14 99642049 G A 0.4087 0.3897 0.4942 Missense p.S375F deleterious BCOR chrX 39933735 C T 0.0000 0.0000 0.5494 Silent p.P288P BMPER chr7 34125385 G A 0.3831 0.3361 0.3044 Missense p.D476N deleterious BNC2 chr9 16436444 A G 0.0000 0.1477 0.0000 Missense p.V583A neutral BRAF chr7 140453136 A T 0.3127 0.2505 0.5536 Missense p.V600E deleterious BRIP1 chr17 59763423 A G 0.0000 0.1405 0.0000 Silent p.N893N BUB1B chr15 40494867 C G 0.0000 0.0000 0.2378 Nonsense p.S569* C10orf47 chr10 11912348 G A 0.3160 0.2876 0.3634 Silent p.S417S C20orf197 chr20 58645831 G T 0.0451 0.0000 0.0000 Silent p.L83L C6orf15 chr6 31079426 C T 0.2650 0.2651 0.2796 Missense p.G237E deleterious CAMK2D chr4 114429408 G A 0.0000 0.3089 0.0000 Intron CAMK2G chr10 75608352 G T 0.2061 0.3304 0.3739 Missense p.P170Q deleterious CCDC15 chr11 124857939 G T 0.0000 0.2573 0.0000 Missense p.R606L deleterious CDH7 chr18 63526217 G T 0.3181 0.3044 0.4101 Missense p.D477Y deleterious CDH7 chr18 63547843 C T 0.3333 0.3174 0.4046 Nonsense p.Q691* CHUK chr10 101964833 A G 0.0000 0.1398 0.0000 Missense p.M452T deleterious COL23A1 chr5 177688731 C A 0.0000 0.2225 0.0000 Missense p.G232W COL4A4 chr2 227920728 G A 0.3611 0.3128 0.3764 Silent p.P883P COL5A1 chr9 137658897 C A 0.0000 0.3243 0.0194 Missense p.Q729K none CORO7 chr16 4410357 G T 0.0000 0.0000 0.3160 Missense p.P677Q neutral CRB1 chr1 197446842 A G 0.0000 0.0964 0.0000 Missense p.T1352A deleterious CRISPLD1 chr8 75926328 A G 0.0000 0.1414 0.0000 Missense p.Y206C deleterious CSF2RB chr22 37334437 C A 0.0271 0.3460 0.0000 Missense p.Q863K deleterious CSRP2BP chr20 18123552 G A 0.2298 0.2290 0.2591 Nonsense p.W83* CXorf64 chrX 125955412 C A 0.0000 0.0000 0.6335 Missense p.P264H deleterious DCHS1 chr11 6661413 G A 0.3212 0.3319 0.4032 Nonsense p.R478* DCLK3 chr3 36779176 G T 0.0326 0.0000 0.0000 Silent p.P325P DDC chr7 50611677 C T 0.3477 0.3380 0.3106 Missense p.G36E deleterious DDX24 chr14 94526827 G A 0.3167 0.3372 0.3671 Silent p.L510L DEFA6 chr8 6782360 G A 0.2993 0.3177 0.3537 Missense p.H95Y neutral DFNB31 chr9 117165203 G A 0.3296 0.3240 0.3889 Missense p.A852V deleterious DLGAP4 chr20 35061095 G A 0.3676 0.3244 0.3649 Silent p.Q325Q DNAH10 chr12 124399540 T C 0.0127 0.0000 0.0000 Silent p.N3454N DNAH10 chr12 124399542 T C 0.0128 0.0000 0.0000 Missense p.L3455P deleterious DYNC1LI2 chr16 66766298 T C 0.0000 0.3289 0.0000 Silent p.T291T EIF3IP1 chr7 109600058 A G 0.0293 0.0000 0.0000 Missense p.W14R ELN chr7 73457315 C T 0.2297 0.2356 0.5612 Silent p.G109G EMR1 chr19 6896539 A G 0.3429 0.3478 0.3767 Silent p.G75G FAM188B chr7 30911873 T C 0.3041 0.3252 0.5249 Silent p.F587F FAM8A1 chr6 17601204 G T 0.0000 0.0480 0.0000 Silent p.R188R FAT4 chr4 126372639 G A 0.2916 0.3159 0.3582 Missense p.A3490T deleterious FCN3 chr1 27697366 C T 0.3051 0.3261 0.3572 Missense p.G164E deleterious FCRL5 chr1 157497544 C T 0.2423 0.2397 0.2724 Missense p.G608E deleterious FZR1 chr19 3534500 C T 0.3141 0.3257 0.3971 Missense p.R477C neutral GNAT1 chr3 50231537 G T 0.0000 0.0000 0.3911 Silent p.V197V GPR50 chrX 150345196 G T 0.0000 0.0000 0.7647 Missense p.M1I deleterious HIPK1 chr1 114483097 G T 0.0000 0.0000 0.3056 Missense p.W31L deleterious HTN3 chr4 70898902 C T 0.3261 0.3639 0.3744 Nonsense p.R41* HUNK chr21 33318417 C A 0.0000 0.0000 0.3952 Missense p.P227H deleterious IGSF5 chr21 41165532 C T 0.3551 0.3257 0.4368 Missense p.P374S deleterious INPP5B chr1 38351321 G A 0.3640 0.3608 0.4075 Silent p.I436I INPP5D chr2 234070438 C T 0.0000 0.0000 0.4010 Silent p.D402D IQUB chr7 123101542 G A 0.3161 0.2288 0.5343 Missense p.R626C deleterious ITGA8 chr10 15726089 G T 0.0000 0.0966 0.0000 Missense p.P161Q neutral ITSN1 chr21 35254735 C A 0.0402 0.0000 0.0000 Missense p.N1510K deleterious JAG2 chr14 105615109 C T 0.0000 0.0000 0.3701 Missense p.G665S deleterious KCNJ9 chr1 160053950 T C 0.0000 0.1036 0.0000 Missense p.Y44H deleterious KIF5C chr2 149866859 C A 0.0000 0.0000 0.4101 Missense p.Q921K deleterious LEFTY2 chr1 226125324 G A 0.2682 0.2820 0.2985 Silent p.F306F LMAN1 chr18 57006063 T A 0.3384 0.3150 0.4078 Nonsense p.R360* LOC100507055 chr12 133181077 C T 0.0000 0.0785 0.0000 Intergenic LOC402160 chr4 2460844 G A 0.3287 0.3431 0.4079 Intergenic LOC645676 chr1 155532876 C T 0.2695 0.2502 0.2938 Missense p.L261F LPP chr3 188326976 C T 0.0000 0.0000 0.0233 Missense p.P153S neutral LRMP chr12 25232349 C T 0.3445 0.3462 0.4187 Missense p.P30L deleterious LRRC8C chr1 90178400 C T 0.3177 0.3296 0.3995 Missense p.P91S neutral LZTS2 chr10 102763394 C T 0.0000 0.3362 0.0000 Missense p.T180M deleterious MAP3K3 chr17 61769747 C T 0.0000 0.0221 0.0000 Silent p.S540S MLL2 chr12 49448153 T C 0.3092 0.3479 0.4152 Silent p.V149V MTMR11 chr1 149906363 C A 0.0000 0.2259 0.0000 Silent p.S175S MUC16 chr19 9056225 C A 0.0197 0.0000 0.0000 Silent p.L10407L MUC16 chr19 9070052 C T 0.3372 0.3226 0.3807 Silent p.E5798E MUC16 chr19 9085017 G A 0.3060 0.2993 0.3365 Silent p.F2266F MUC16 chr19 9085057 G A 0.2716 0.2915 0.3207 Missense p.S2253F none MYH2 chr17 10426927 C T 0.0164 0.0000 0.0000 Silent p.E1786E MYH2 chr17 10440818 G A 0.3277 0.3441 0.4076 Silent p.F543F MYO1E chr15 59519686 C G 0.3066 0.3232 0.5701 Missense p.G205A deleterious MYO9A chr15 72146889 G A 0.3282 0.3197 0.5669 Nonsense p.R2059* NEFM chr8 24775926 T C 0.0000 0.0624 0.0000 Missense p.V853A deleterious NOL12 chr22 38083955 G A 0.3353 0.3293 0.3685 Missense p.R41Q deleterious NRAS chr1 115256529 T C 0.0000 0.0551 0.0000 Missense p.Q61R neutral NRAS chr1 115256530 G T 0.0000 0.1822 0.0000 Missense p.Q61K deleterious NUB1 chr7 151073752 C T 0.0000 0.0000 0.2713 Silent p.A532A NUP155 chr5 37301594 G A 0.2962 0.2369 0.3754 Missense p.S1169F neutral NUP37 chr12 102470609 T C 0.0000 0.1296 0.0000 Missense p.R247G deleterious ODZ3 chr4 183594331 G T 0.0153 0.0000 0.0000 Nonsense p.G429* ODZ3 chr4 183601766 G T 0.3283 0.3282 0.3662 Missense p.W570C deleterious ODZ4 chr11 78780946 C T 0.0000 0.0615 0.0000 Missense p.R15H OR11L1 chr1 248004389 G A 0.2358 0.2252 0.2700 Silent p.I270I OR9K2 chr12 55524218 G A 0.2635 0.2955 0.3628 Missense p.M222I neutral OVCH1 chr12 29649206 G A 0.3478 0.3160 0.3729 Silent p.S63S PAMR1 chr11 35456144 C T 0.3319 0.3137 0.4004 Missense p.M514I neutral PCM1 chr8 17843021 T C 0.0000 0.1451 0.0000 Silent p.L1392L PELP1 chr17 4579137 G A 0.3129 0.3250 0.3851 Silent p.I341I PGBD1 chr6 28269512 T C 0.0606 0.0000 0.0000 Silent p.D627D PIK3CA chr3 178952085 A G 0.0000 0.1122 0.0000 Missense p.H1047R deleterious PLD3 chr19 40876142 C A 0.0000 0.3267 0.0000 Missense p.Q226K deleterious PLOD1 chr1 12034860 C T 0.3373 0.3356 0.4106 Missense p.P727S deleterious PQLC1 chr18 77679306 G A 0.0000 0.1343 0.0000 Silent p.Y162Y PTGER3 chr1 71418665 C T 0.3356 0.3411 0.4087 Intron PTPRT chr20 40980824 C A 0.0315 0.0000 0.0000 Silent p.V554V RAD50 chr5 131973778 G A 0.0000 0.0000 0.0292 Missense p.E1161K deleterious RAD54B chr8 95399294 G C 0.0363 0.0000 0.0000 Missense p.L635V RECQL4 chr8 145737837 C A 0.0000 0.0000 0.3474 Missense p.W998L deleterious RGNEF chr5 73188000 A T 0.3338 0.3042 0.3906 Missense p.N1171Y neutral RIMS1 chr6 72678741 G A 0.3409 0.3322 0.3698 Missense p.E74K neutral RYR1 chr19 38946164 G A 0.3548 0.3231 0.4127 Silent p.L550L SEMA3E chr7 82997041 T G 0.3913 0.4812 0.3082 Missense p.E730A neutral SERPINB7 chr18 61449677 G A 0.2906 0.3189 0.3625 Missense p.G24E neutral SGSM1 chr22 25255792 T C 0.0000 0.0422 0.0000 Missense p.L304P neutral SLC22A10 chr11 63057779 C T 0.3323 0.3383 0.4106 Missense p.R48C deleterious SLITRK1 chr13 84454538 C A 0.2174 0.3223 0.3844 Missense p.D369Y deleterious SPATA17 chr1 217955596 C T 0.2313 0.2427 0.2682 Silent p.I268I ST6GAL1 chr3 186760941 A G 0.0000 0.0179 0.0000 Silent p.V150V SULT1C2 chr2 108917375 G T 0.0000 0.0000 0.3683 Missense p.W120L deleterious SV2C chr5 75427614 G T 0.0000 0.0122 0.0000 Missense p.K13N neutral SYTL2 chr11 85445660 C A 0.0680 0.0000 0.0000 Missense p.A237S neutral TAAR1 chr6 132966335 A G 0.0000 0.0558 0.0000 Missense p.C270R deleterious TAS2R38 chr7 141673292 G A 0.3684 0.4871 0.2838 Silent p.F66F TCHHL1 chr1 152057922 C T 0.2329 0.2472 0.2738 Missense p.E746K deleterious TECRL chr4 65147222 G A 0.3256 0.3022 0.3652 Silent p.F296F TLR10 chr4 38774816 C G 0.3697 0.3678 0.4370 Missense p.R799P deleterious TMEM109 chr11 60687246 C T 0.3362 0.3229 0.3955 Silent p.L27L TMEM201 chr1 9667714 C A 0.0000 0.4204 0.0000 Silent p.P420P TSN chr2 122516309 C T 0.3255 0.3225 0.4231 Nonsense p.R62* TTN chr2 179409212 G A 0.3442 0.3346 0.4125 Missense p.A29347V neutral TTN chr2 179615786 C T 0.3111 0.3171 0.3715 Missense p.D3781N TTN chr2 179629403 G A 0.3096 0.2936 0.3590 Missense p.S3280F deleterious TXNDC2 chr18 9886223 G T 0.0000 0.2925 0.0000 Nonsense p.G18* ULBP1 chr6 150290473 G T 0.0000 0.3232 0.0000 Missense p.W201L deleterious VWCE chr11 61058805 C A 0.0000 0.3494 0.0000 Missense p.G76W deleterious WDFY4 chr10 49931482 C T 0.2487 0.3253 0.3814 Missense p.T154M deleterious WDR64 chr1 241929525 C T 0.4739 0.4989 0.5783 Silent p.P361P XKR7 chr20 30585013 C A 0.0000 0.0890 0.0000 Missense p.P498Q deleterious ZBTB49 chr4 4322600 C A 0.0000 0.0000 0.3763 Missense p.Q619K neutral ZKSCAN3 chr6 28333607 C A 0.0000 0.2357 0.0000 Missense p.H388N deleterious ZMYND10 chr3 50380598 C A 0.0482 0.0000 0.3606 Missense p.A184S neutral ZNF193 chr6 28200526 G A 0.0000 0.0680 0.0000 Missense p.G252E neutral ZNF423 chr16 49669750 C A 0.0909 0.0000 0.0000 Missense p.G1105C neutral ZNF446 chr19 58991961 G A 0.4085 0.3973 0.4197 Silent p.K407K ZNF652 chr17 47390148 G A 0.3433 0.3504 0.3732 Silent p.I320I ZNF677 chr19 53741012 A G 0.0000 0.0890 0.0000 Missense p.I323T deleterious ZNF750 chr17 80789160 C A 0.0000 0.2662 0.0000 Missense p.G391W neutral Suppl. Table 3. Cancer genes in aneuploidy regions.

Region CNA type Sample Cancer Gene Census ABL2, AF1Q, ARNT, BCL9, ELK4, PRE (clonal) FCGR2B, FH, H3F3A, HRPT2, IRTA1, 1q Trisomy PV1 (clonal) MDM4, MUC1, NTRK1, PBX1, PDE4DIP, PV2 (clonal) PMX1, PRCC, SDHC, SLC45A3, TPM3, TPR 5p Trisomy PV1 (clonal) IL7R, LIFR

PRE (clonal) CCND3, DAXX, DEK, FANCE, HIST1H4I, 6p Trisomy PV1 (clonal) HMGA1, HSPCB, IRF4, PIM1, POU5F1, PV2 (clonal) SFRS3, TFEB, TRIM27 CARD11, EGFR, ETV1, HNRNPA2B1, PRE (subclonal) 7p Trisomy HOXA11, HOXA13, HOXA9, IKZF1, PV2 (clonal) JAZF1, PMS2 PRE (subclonal) AKAP9, BRAF, CDK6, CREB3L2, ELN, 7q Trisomy PV1 (clonal) EZH2, HIP1, HLXB9, KIAA1549, MET, PV2 (clonal) MLL3, SBDS, SMO, TIF1, TRB@ BMPR1A, CCDC6, COPEB, D10S170, FAM22A, FAM22B, FGFR2, GATA3, 10 Monosomy PRE (subclonal) KIF5B, LCX, MLLT10, MYST4, NCOA4, NFKB2, PRF1, PTEN, RET, SSH3BP1, SUFU, TCF7L2, TLX1, TNFRSF6, VTI1A AF15Q14, BLM, BUB1B, C15orf21, 15 Trisomy PV2 (clonal) C15orf55, CRTC3, FLJ27352, IDH2, NTRK3, PML, TCF12 CBFA2T3, CBFB, CDH1, CDH11, CYLD, 16q Monosomy PV1 (subclonal) FANCA, HERPUD1, MAF PRE (clonal) 20p Trisomy PV1 (clonal) --- PV2 (clonal) PV1 (subclonal) Y Deletion CRLF2, P2RY8 PV2 (subclonal)

Note: There are also focal amplification of the 4 TR genes loci: TRA (14q11.2), TRB (7q34), TRG (7p14), TRD(14q11.2) Suppl. Table 4. RNA-seq log2 normalized gene counts for genes belonging tp tyrosine kinase receptor family, RAS/MAPK and AKT/mTOR signaling pathways. Vem-naive Gene Pathway Chr PV1 norm PV2 norm norm ADAR PI3K/AKT 1q21.3 16.78 16.10 16.57 AKT1 PI3K/AKT 14q32.32 14.88 14.91 14.29 AKT1S1 mTOR 19q13.33 14.38 13.64 14.67 AKT2 PI3K/AKT 19q13.1-q13.2 15.26 14.13 14.64 AKT3 PI3K/AKT 1q44 14.44 15.23 13.13 APC PI3K/AKT 5q21-q22 13.12 13.11 13.21 ARAF MAPK Xp11.4-p11.2 13.33 12.96 13.35 BAD PI3K/AKT 11q13.1 9.65 11.38 10.42 BRAF MAPK 7q34 12.53 12.60 11.79 BTK PI3K/AKT Xq21.33-q22 12.81 8.67 13.55 CAB39 mTOR 2q37.1 14.05 13.96 14.59 CAB39L mTOR 13q14.2 11.52 11.69 11.33 CASP9 PI3K/AKT 1p36.21 11.92 12.23 11.90 CCND1 PI3K/AKT 11q13 15.87 14.42 15.47 CD14 PI3K/AKT 5q31.1 14.44 11.98 15.60 CDC42 PI3K/AKT 1p36.1 15.10 15.90 15.37 CDKN1B PI3K/AKT 12p13.1-p12 13.29 13.70 14.13 CHUK mTOR 10q24-q25 13.65 13.16 12.58 CSNK2A1 PI3K/AKT 20p13 15.96 15.59 14.21 CTNNB1 PI3K/AKT 3p21 17.89 18.77 16.88 DDIT4 mTOR 10q22.1 15.42 15.69 15.97 DDIT4L mTOR 4q24 8.35 8.34 9.60 DEPTOR mTOR 8q24.12 10.22 12.17 9.35 EDNRA GPCR/other 4q31.22 10.94 9.09 10.20 EDNRB GPCR/other 13q22 13.76 17.64 14.85 EGFR RTK 7p12 8.92 7.71 10.01 EIF2AK2 PI3K/AKT 2p22-p21 14.34 14.01 14.31 EIF4B mTOR 12q13.13 17.32 17.89 15.85 EIF4E mTOR 4q21-q25 13.69 13.80 12.91 EIF4EBP1 mTOR 8p12 14.63 14.47 12.75 EIF4EBP2 mTOR 10q21-q22 15.42 14.99 14.31 ELK1 PI3K/AKT Xp11.2 13.61 13.33 12.68 EPHA2 RTK 1p36 12.22 10.16 13.21 EPHA3 RTK 3p11.2 8.71 8.68 7.94 EPHA4 RTK 2q36.1 12.71 13.56 10.85 EPHA5 RTK 4q13.1 12.03 12.47 9.97 EPHB3 RTK 3q21-qter 7.24 6.78 10.61 EPHB4 RTK 7q22 14.60 15.03 13.45 ERBB2 RTK 17q21.1 13.90 14.00 12.27 ERBB3 RTK 12q13 16.58 17.95 15.15 FGFR1 RTK 8p12 13.92 14.98 13.15 FGFR3 RTK 4p16.3 4.78 5.14 5.19 FGFR4 RTK 5q35.1-qter 11.06 11.92 10.09 FKBP1A mTOR 20p13 16.74 16.53 15.25 FKBP8 mTOR 19p12 14.92 15.55 15.00 FOS PI3K/AKT 14q24.3 15.27 14.11 14.03 FRS2 RTK 12q15 13.13 12.89 12.70 GJA1 PI3K/AKT 6q21-q23.2 11.54 11.75 12.19 GRB10 PI3K/AKT 7p12.2 13.46 14.62 12.89 GRB2 PI3K/AKT 17q24-q25 14.17 13.83 14.68 GRIN2A GPCR/other 16p13.2 9.40 6.60 7.43 GRM1 GPCR/other 6q24 4.39 12.91 3.97 GRM3 GPCR/other 7q21.1-q21.2 6.83 6.88 6.42 GSK3B mTOR 3q13.3 14.27 14.58 13.58 HGF RTK 7q21.1 9.78 7.39 10.21 HIF1A mTOR 14q23.2 15.45 15.99 14.59 HRAS MAPK 11p15.5 11.88 12.43 11.67 HSPA4 mTOR 5q31.1 16.55 16.08 15.03 HSPB1 PI3K/AKT 7q11.23 16.50 15.80 15.36 IGF1 PI3K/AKT 12q23.2 10.93 10.67 10.12 IGF1R RTK 15q26.3 14.99 16.26 13.63 IGFBP3 mTOR 7p13-p12 12.58 12.09 15.91 IKBKB mTOR 8p11.2 14.12 14.06 14.59 ILK PI3K/AKT 11p15.4 8.67 7.24 9.88 INSR mTOR 19p13.3-p13.2 13.64 13.80 13.84 IRAK1 PI3K/AKT Xq28 15.25 14.15 14.68 IRS1 PI3K/AKT 2q36 11.83 10.75 10.38 JUN MAPK 1p32-p31 13.38 11.34 14.05 KIT RTK 4q11-q12 8.73 3.37 10.62 KRAS MAPK 12p12.1 13.54 13.34 13.06 KSR1 MAPK 17q11.2 11.96 11.77 13.36 LAMTOR3 MAPK 4q23 12.59 13.57 13.04 MAP2K1 MAPK 15q22.1-q22.33 13.77 14.12 13.39 MAP2K2 MAPK 19p13.3 14.60 14.73 14.29 MAP2K3 MAPK 17q11.2 14.19 13.67 13.22 MAP2K4 MAPK 17p12 13.02 12.97 12.69 MAP2K5 MAPK 15q23 12.26 12.86 11.58 MAP2K6 MAPK 17q24.3 5.63 10.58 9.46 MAP2K7 MAPK 19p13.3-p13.2 13.68 13.23 13.33 MAP3K1 MAPK 5q11.2 14.09 14.21 14.21 MAP3K2 MAPK 2q14.3 13.33 13.37 14.37 MAP3K3 MAPK 17q23.3 13.54 13.00 14.02 MAP3K4 MAPK 6q26 12.29 12.67 12.18 MAP3K8 MAPK 10p11.23 11.28 9.70 12.37 MAP4K1 MAPK 19q13.1-q13.4 11.62 6.33 13.83 MAPK1 MAPK 22q11.21 15.35 15.06 14.58 MAPK10 MAPK 4q22.1-q23 5.00 5.91 6.95 MAPK11 MAPK 22q13.33 12.28 13.50 12.50 MAPK12 MAPK 22q13.33 12.31 12.56 13.02 MAPK13 MAPK 6p21.31 10.82 8.38 12.70 MAPK14 MAPK 6p21.3-p21.2 14.22 14.12 13.68 MAPK3 MAPK 16p11.2 13.16 13.29 12.59 MAPK6 MAPK 15q21 14.07 14.49 13.01 MAPK7 MAPK 17p11.2 12.39 11.76 12.45 MAPK8 PI3K/AKT 10q11.22 12.58 13.36 12.52 MAPK8IP2 MAPK 22q13.33 5.27 5.30 9.13 MAPK9 MAPK 5q35 12.90 12.87 13.30 MAPKAP1 mTOR 9q33.3 14.44 14.40 13.48 MAPKAPK2 MAPK 1q32 15.25 15.46 15.62 MAPKAPK3 MAPK 3p21.3 13.87 13.68 13.66 MAX MAPK 14q23 14.15 14.07 14.24 MEF2C MAPK 5q14 11.99 11.83 13.52 MET RTK 7q31 8.68 13.19 12.82 MKNK1 MAPK 1p33 13.30 12.73 14.03 MLST8 mTOR 16p13.3 13.14 13.73 12.31 MST1 MAPK 3p21 10.07 10.29 13.14 MTCP1 PI3K/AKT Xq28 8.36 8.01 9.58 MTOR PI3K/AKT 1p36.2 14.83 14.07 14.30 MYC MAPK 8q24.21 14.00 15.93 13.22 MYD88 PI3K/AKT 3p22 14.31 13.65 14.52 MYO1C mTOR 17p13.3 15.95 15.54 15.54 NF1 MAPK 17q11.2 14.95 14.93 14.35 NFATC4 MAPK 14q11.2 11.10 9.60 13.41 NFKB1 PI3K/AKT 4q24 13.66 13.12 13.53 NRAS MAPK 1p13.2 14.88 14.59 13.70 NTRK1 RTK 1q21-q22 8.63 7.42 9.01 NTRK2 RTK 9q22.1 7.11 4.22 8.88 NTRK3 RTK 15q25 4.53 3.86 9.01 PAK1 MAPK 11q13-q14 13.78 13.15 13.59 PDGFRA RTK 4q12 11.33 11.07 12.84 PDGFRB RTK 5q33.1 14.03 12.68 14.23 PDK1 PI3K/AKT 2q31.1 12.11 11.54 14.62 PDK2 PI3K/AKT 17q21.33 11.39 11.43 11.02 PDPK1 PI3K/AKT 16p13.3 13.45 13.03 13.57 PIK3C3 mTOR 18q12.3 14.11 14.11 13.38 PIK3CA PI3K/AKT 3q26.3 13.01 13.49 13.24 PIK3CB mTOR 3q22.3 13.82 14.10 13.78 PIK3CD mTOR 1p36.2 15.63 14.89 14.35 PIK3CG PI3K/AKT 7q22.3 10.00 6.18 12.20 PIK3R1 PI3K/AKT 5q13.1 14.18 14.41 13.94 PIK3R2 PI3K/AKT 19q13.2-q13.4 14.70 14.21 12.88 PLD1 mTOR 3q26 14.77 14.76 12.18 PLD2 mTOR 17p13.1 12.81 12.73 13.39 PPP2CA mTOR 5q31.1 14.54 14.83 14.30 PPP2R2B mTOR 5q32 5.43 7.31 10.57 PPP2R4 mTOR 9q34 15.11 15.40 14.83 PRDX6 MAPK 1q25.1 15.76 16.04 14.69 PRKAA1 mTOR 5p12 14.27 13.86 13.99 PRKAA2 mTOR 1p31 4.23 4.51 8.86 PRKAB1 mTOR 12q24.1-q24.3 13.25 12.82 12.53 PRKAB2 mTOR 1q21.1 14.19 14.05 12.43 PRKAG1 mTOR 12q12-q14 14.18 14.48 13.05 PRKAG2 mTOR 7q36.1 12.89 12.45 12.05 PRKCA PI3K/AKT 17q22-q23.2 11.80 10.39 9.70 PRKCB PI3K/AKT 16p11.2 13.88 12.79 13.29 PRKCE mTOR 2p21 13.30 13.30 11.72 PRKCG mTOR 19q13.4 1.73 3.37 10.26 PRKCZ PI3K/AKT 1p36.33-p36.2 11.37 10.23 11.47 PTEN PI3K/AKT 10q23.3 13.84 14.54 13.95 PTK2 PI3K/AKT 8q24.3 14.32 14.77 13.39 RAC1 MAPK 7p22 16.19 16.47 15.42 RAF1 MAPK 3p25 14.63 13.90 14.77 RASA1 PI3K/AKT 5q13.3 13.48 13.75 13.48 RB1 MAPK 13q14.2 14.75 14.33 14.06 RBL2 PI3K/AKT 16q12.2 13.76 14.09 14.32 RHEB PI3K/AKT 7q36 14.33 15.39 14.53 RHOA PI3K/AKT 3p21.3 16.94 16.68 16.40 RICTOR mTOR 5p13.1 14.16 13.76 13.90 RPS6 mTOR 9p21 17.97 18.88 17.00 RPS6KA1 mTOR 1p 13.45 12.87 13.99 RPS6KA2 mTOR 6q27 15.21 16.51 11.94 RPS6KA5 mTOR 14q31-q32.1 12.89 12.30 11.56 RPS6KB1 mTOR 17q23.1 12.36 12.20 13.35 RPS6KB2 mTOR 11q13.2 12.31 11.90 13.02 RPTOR mTOR 17q25.3 13.43 13.30 12.75 RRAGA mTOR 9p22.1 14.04 14.59 13.18 RRAGB mTOR Xp11.21 11.04 11.82 11.90 RRAGC mTOR 1p34 13.67 13.99 12.97 RRAGD mTOR 6q15-q16 13.97 14.29 13.17 SFN MAPK 1p36.11 5.18 2.63 4.50 SGK1 mTOR 6q23 17.45 16.88 16.12 SHC1 PI3K/AKT 1q21 16.22 15.78 16.10 SMAD4 MAPK 18q21.1 14.40 14.52 13.76 SOS1 PI3K/AKT 2p21 13.77 13.91 14.33 SRF PI3K/AKT 6p21.1 14.91 14.19 13.04 STK11 mTOR 19p13.3 13.29 13.29 13.17 STRADB mTOR 2q33.1 14.26 13.72 12.20 TCL1A PI3K/AKT 14q32.1 5.63 2.63 5.75 TELO2 mTOR 16p13.3 13.72 13.36 13.50 TIRAP PI3K/AKT 11q24.2 11.23 10.97 11.22 TLR4 PI3K/AKT 9q33.1 12.66 12.36 13.25 TOLLIP PI3K/AKT 11p15.5 13.64 13.80 13.28 TP53 MAPK 17p13.1 13.97 14.53 13.14 TSC1 mTOR 9q34 13.51 13.91 13.84 TSC2 mTOR 16p13.3 15.22 13.97 14.56 ULK1 mTOR 12q24.3 13.15 12.66 13.42 ULK2 mTOR 17p11.2 12.66 11.62 12.54 VEGFA mTOR 6p12 14.49 14.82 15.73 VEGFB mTOR 11q13 14.18 14.66 13.79 VEGFC mTOR 4q34.3 9.84 7.82 10.58 WASL PI3K/AKT 7q31.3 15.07 14.63 14.37 YWHAQ mTOR 2p25.1 15.75 16.04 14.56