EDCTP portfolio: medical interventions against poverty-related infectious diseases

(2014-2019)

Non-phase diagnostic Phase Ia/b Phase IIa/b Phase III Phase IV Observational study trial

VirTUAL CAPRISA 018 POR TB CHAPS STOP PREGART CAP-TB DREAMM Uganda, South Africa South Africa South Africa, Tanzania South Africa, Uganda Ethiopia, Kenya, Ethiopia, Uganda Tanzania, Mozambique Cameroon, Malawi, Mozambique Tanzania

MoxiMultiDoseMod PROMISE-EPI MMVC AMBITION-cm PZQ4PSAC 5FC HIV-Crypto Predict TB DIAMA DR Congo, Ghana Burkina Faso, Zimbabwe Burkina Faso, Kenya, Botswana, Malawi, Cote d’Ivoire, Kenya Ethiopia, Uganda South Africa Benin, Cameroon, DR Congo, Sierra Leone, Tanzania South Africa, Uganda, Zimbabwe Ethiopia, Guinea, Mali, Nigeria, Rwanda, Senegal PEAU-EBOV-RDC PanACEA PfTBV CHAPAS-4 AfriKADIA TREATS RaPaed TB Ethiopia, Malawi, Mali, Burkina Faso, Guinea, Uganda, Zambia, Zimbabwe Ethiopia, Kenya, Sudan, South Africa, Zambia Malawi, South Africa, Stop TB/HIV at one Mozambique, Nigeria, Rwanda, Liberia, Mali Uganda Tanzania Ethiopia, Nigeria South Africa, Senegal, Tanzania CAP012 SAMBA Trial MIMVac-Africa BREATHER Plus COAST-Nutrition PEOPLE PreFIT South Africa, Zambia CLICK-TB Burkina Faso, Gabon, Kenya, South Africa, Uganda, Kenya, Uganda Comoros, Madagascar Mozambique, South Africa, Screen TB South Africa Mozambique, Tanzania Zimbabwe Uganda Ethiopia, The Gambia, Namibia, South Africa, Uganda MMVC PREV-PKDL VITALITY priMe FibroScHot XACT III The Gambia, Kenya StatinTB Ethiopia, Kenya, Sudan, Zambia, Zimbabwe Gabon, Kenya, South Africa, Uganda Mozambique, South Africa, DIAMA South Africa Uganda Tanzania, Uganda Zimbabwe Benin, Cameroon, DR Congo, Ethiopia, Guinea, Mali, Nigeria, PfTBV ShigOraVax META TRIAL THECA PEP4LEP SeroSelectTB Rwanda, Senegal Burkina Faso, Guinea, Simplici-TB Burkina Faso, Zambia Tanzania Burkina Faso, DR Congo, Ethiopia, Mozambique, Ethiopia, Tanzania, TriageTB Liberia, Mali Gabon, Malawi, Mozambique, Ghana, Madagascar Tanzania South Africa South Africa, Tanzania, Uganda The Gambia, South Africa, MIMVac-Africa PREPARE INTENSE-TBM BabyGel PediCAP STool4TB Uganda Burkina Faso, Gabon, DATURA South Africa, Uganda Cote d’Ivoire, Madagascar, South Africa, Uganda, Eswatini, Mozambique, Mozambique, Tanzania Cameroon, Guinea, South Africa, Uganda Zambia, Zimbabwe Uganda Tanzania, Uganda ETEC Vaccine Efficacy PREVAC-UP PROTID ETEC, ETVAX NIFTY ERASE-TB The Gambia, Zambia WANECAM II Guinea, Liberia, Mali, Tanzania, Uganda Zambia Senegal, Uganda Mozambique, Tanzania, Burkina Faso, Gabon, Mali, Sierra Leone Zimbabwe Niger ShigOraVax WANECAM II DIAGMAL LIFE Study TB TRIAGE+ Burkina Faso, Zambia PAMAFRICA Burkina Faso, Gabon, Burkina Faso, Ethiopia, Mozambique, Tanzania Lesotho, South Africa Intervention Burkina Faso, Gabon, Mali, Niger Kenya, Namibia, Sudan Drugs Mozambique, Uganda IMPROVE AfriKADIA Vaccines SINDOFO Kenya, Malawi, Tanzania Ethiopia, Kenya, Diagnostics Burkina Faso, Kenya, Sudan, Uganda Mozambique Other IMPROVE-2 DiTECT-HAT Product-focused implementation HAT-r-ACC Kenya, Malawi Cote d’Ivoire, Burkina Faso, research Malawi, Uganda, Zambia DR Congo, Guinea Disease MAMAH FREEBILY HIV and HIV associated infections EMPIRICAL Gabon, Mozambique Madagascar, Gabon Tuberculosis Code d’Ivoire, Malawi, Mozambique, Uganda, Malaria ASAAP SOLID Zambia, Zimbabwe Neglected infectious diseases Benin, Burkina Faso, Tanzania, Zambia GREAT Gabon, Ghana, Mali Emerging diseases Kenya, Uganda, Zambia Lower respiratory tract infections PYRAPREG LAMP4Yaws Burkina Faso, DR Congo, Cameroon, Cote d’Ivoire, Diarrhoeal diseases Neo bnAb The Gambia, Mali, Mozambique Ghana Population Mozambique, Tanzania MoxiMultiDoseMod AdjustEBOVGP-Dx Adults (18yr and above) DR Congo, Ghana DR Congo Adolescents (10yr-17yr) PrEPVacc Children (2yr-9yr) Mozambique, Tanzania, Infants (above 1mo-1yr) Uganda HAT-r-ACC MobEBO-DRC Malawi, Uganda, Zambia DR Congo Pregnant women and/or MTBVAC-Newborns newborns (birth to 1mo) South Africa

14 15