Working with Hazardous Chemicals
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(PAC) Rev 24 Based on Applicable Aegls, Erpgs, Or Teels (Chemicals Listed by CASRN) PAC Rev 24 – August 2008
Table 3: Protective Action Criteria (PAC) Rev 24 based on applicable AEGLs, ERPGs, or TEELs (Chemicals listed By CASRN) PAC Rev 24 – August 2008 Table 3 presents a listing of chemicals and PAC data based on the Chemical Abstract Service Registry Numbers (CASRNs)1 of the chemicals. Chemicals without an identified CASRN number are issued an identification number, preceded by the letter “z,” for purposes of the PAC data set. The columns presented in Table 3 provide the following information: Heading Definition No. The ordered numbering of the chemicals as they appear in this listing by CASRN. Chemical Name The common name of the chemical. CASRN The Chemical Abstract Service Registry Number for this chemical. TEEL-0 This is the threshold concentration below which most people will experience no appreciable risk of health effects. This PAC is always based on TEEL-0 because AEGL-0 or ERPG-0 values do not exist. PAC-1 Based on the applicable AEGL-1, ERPG-1, or TEEL-1 value. PAC-2 Based on the applicable AEGL-2, ERPG-2, or TEEL-2 value. PAC-3 Based on the applicable AEGL-3, ERPG-3, or TEEL-3 value. Units The units for the PAC values (ppm or mg/m3). Additional information on the chemicals presented here is provided in PAC Tables 1, 2, and 4. Table 3, other PAC Tables, introductory/explanatory material (including a glossary of acronyms and abbreviations), definitions of PAC values, and alternative methods of displaying PAC information are available electronically at: http://www.hss.energy.gov/HealthSafety/WSHP/chem_safety/teel.html. -
Campro Catalog Stable Isotope
Introduction & Welcome Dear Valued Customer, We are pleased to present to you our Stable Isotopes Catalog which contains more than three thousand (3000) high quality labeled compounds. You will find new additions that are beneficial for your research. Campro Scientific is proud to work together with Isotec, Inc. for the distribution and marketing of their stable isotopes. We have been working with Isotec for more than twenty years and know that their products meet the highest standard. Campro Scientific was founded in 1981 and we provide services to some of the most prestigious universities, research institutes and laboratories throughout Europe. We are a research-oriented company specialized in supporting the requirements of the scientific community. We are the exclusive distributor of some of the world’s leading producers of research chemicals, radioisotopes, stable isotopes and environmental standards. We understand the requirements of our customers, and work every day to fulfill them. In working with us you are guaranteed to receive: - Excellent customer service - High quality products - Dependable service - Efficient distribution The highly educated staff at Campro’s headquarters and sales office is ready to assist you with your questions and product requirements. Feel free to call us at any time. Sincerely, Dr. Ahmad Rajabi General Manager 180/280 = unlabeled 185/285 = 15N labeled 181/281 = double labeled (13C+15N, 13C+D, 15N+18O etc.) 186/286 = 12C labeled 182/282 = d labeled 187/287 = 17O labeled 183/283 = 13C labeleld 188/288 = 18O labeled 184/284 = 16O labeled, 14N labeled 189/289 = Noble Gases Table of Contents Ordering Information.................................................................................................. page 4 - 5 Packaging Information .............................................................................................. -
European Journal of Chemistry 5 (4) (2014) 681‐694
European Journal of Chemistry 5 (4) (2014) 681‐694 European Journal of Chemistry Journal homepage: www.eurjchem.com Synthesis, reactions and applications of pyranotriazolopyrimidines Ashraf Hassan Fekry Abd El‐Wahab a,b,*, Ibrahim Ali Radini a and Hany Mostafa Mohamed a,b a Chemistry Department, Faculty of Science, Jazan University, 2097, Jazan, Saudi Arabia b Chemistry Department, Faculty of Science, Al‐Azhar University, 11884, Nasr City, Cairo, Egypt *Corresponding author at: Chemistry Department, Faculty of Science, Jazan University, 2097, Jazan, Saudi Arabia. Tel.: +966.054.0963753. Fax: +966.017.3230028. E‐mail address: [email protected] (A.H.F.A. El‐Wahab). REVIEW INFORMATION ABSTRACT This review deals with synthesis, reactions and their applications of pyranotriazolo‐ pyrimidines. The main purpose of this review is present a survey of literatures on the reactivity of amino imino derivatives and carboxylic acid derivatives. Some of these reactions have been applied successfully to the synthesis of biological important compounds. DOI: 10.5155/eurjchem.5.4.681‐694.1087 Received: 30 April 2014 Received in revised form: 27 May 2014 Accepted: 27 May 2014 Online: 31 December 2014 KEYWORDS Naphthols Pyrimidine Biological activity Pyranopyrimidines α‐Cyanocinnamonitriles Carboxylic acid derivatives 1. Introduction chemical and biological view points, due to their diverse pharmacological activities, such as antitumor potency [19,20], Pyran derivatives have attracted a great deal of interest inhibition of KDR kinase [21], antifungal effect [22] and owing to their antimicrobial activity [1‐7], inhibition of influ‐ macrophage activation [23]. enza, virus sialidase [8], mutagenic activity [9], activity as antiviral [10], anti‐proliferaction agents [11], sex pheromones [12], antitumor [13] and anti‐inflammatory agents [14]. -
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SYNTHESIS OF FUSED AND NONFUSED HETEROCYCLES FROM 5- AND 8-SUBSTITUTED 3-HYDRAZINO-l,2,4-TRIAZINO[5,6-Z>]INDOLE Hamida Abdel Hamid, Ahmed Mousaad, El Sayed Ramadan and El Sayed H. El Ashry* Chemistry Department, Faculty of Science, Alexandria University, Alexandria, Egypt Abstract: The 7-and 10-substituted 1,2,4-triazolo[4\3':2,3][l,2,4]triazino[5,6-i]indoles were prepared by the reaction of 5- and 8-substituted-3-hydrazino-l,2,4-triazino[5,6-i>]indole with formic acid ortriethyl orthoformate. Reaction of the hydrazines with acetylacetone, ethyl acetoacetate and ethyl cyanoacetate gave the respective biheterocycles containing pvrazole and pyrazolone rings. Reaction of the hydrazines with carbondisulphide, thiourea, urea, ethyl chloroformate as well as nitrous acid have been investigated. Reaction of 5-allyl-3-methylthio-1,2,4-triazino[5,6-6]indole with ethanolamine followed by cyclization gave the imidazotriazinoindole. INTRODUCTION The l,2,4-triazino[5,6-i]indole ring has been found to be a useful carrier for various functional groups for developing antiviral and antibacterial activities [1-8], The imidazo, pyrimido or triazolo-1,2,4- triazino[5,6-6]indoles showed also antiviral and antibacterial properties [9], The arylidene moiety of 3- arylidene and heterocyclic formylidenehydrazono-l,2,4-triazino[5,6-&]indole derivatives has been found to play a role on their activity against Staphylococcus aureus and Bacillus cereus as well as Ρ 388 lymphocytic leukemia [8]. The 3-hydrazino-1,2,4-triazino[5,6-A]indole and 3-hydrazino-5,6-diphenyl-l,2,4-triazine have an effect on the carbohydrate metabolism and lipid components in rat [10,11], The regioselective annelation of a triazole ring to the 1,2,4-triazino[5,6-b] indole either via the dehydrative cyclization of the respective hydrazide or the dehydrogenative cyclization of the hydrazones has been reported [12-16]. -
(12) Patent Application Publication (10) Pub. No.: US 2011/0004.002 A1 Maywald Et Al
US 2011 00040O2A1 (19) United States (12) Patent Application Publication (10) Pub. No.: US 2011/0004.002 A1 Maywald et al. (43) Pub. Date: Jan. 6, 2011 (54) PROCESS FOR PREPARING ALKYL 2-ALKOXYMETHYLENE-44-DIFLUORO-3- OXOBUTYRATES O O (I) (75) Inventors: Volker Maywald, Ludwigshafen F (DE); Sebastian Peer Smidt, OR, Offersheim (DE); Bernd Wolf, F Fussgoenheim (DE); Christopher Koradin, Ludwigshafen (DE); b Thomas Zierke, Boehl-Iggelheim Rreacting (DE); Michael Rack, Eppelheim (DE); Michael Keil, Freinsheim (DE) (II) O Correspondence Address: ls BRINKS, HOFER, GILSON & LIONE HC OR, P.O. BOX 110285 alkyl acetate RESEARCH TRIANGLE PARK, NC 27709 (US) (III) ROM (73) Assignee: BASF SE, Ludwigshafen (DE) alkoxide, (21) Appl. No.: 12/919,842 where M is a sodium or potassium ion, and (22) PCT Filed: Feb. 27, 2009 (IV) (86). PCT No.: PCT/EP09/52378 S371 (c)(1), OR, (2), (4) Date: Aug. 27, 2010 F alkyl (30) Foreign Application Priority Data difluoroacetate Feb. 29, 2008 (EP) .................................. O81021974 without additional solvent to form an enolate (V) Publication Classification (V) OM O (51) Int. Cl. F N CO7D 231/4 (2006.01) OR, CD7C 69/66 (2006.01) (52) U.S. Cl. ...................................... 548/374.1; 560/177 b) releasing the corresponding alkyl 4,4-difluoroacetoacetate (I) from the enolate (V) by means of acid, c) removing the salt formed from cation Mandacid anion as (57) ABSTRACT a solid and d) converting (I), without isolation from the crude reaction A process for preparing alkyl 2-alkoxymethylene-4,4-dif mixture, to the alkyl 2-alkoxymethylene-4,4-difluoro-3- luoro-3-oxobutyrates (VI) oxobutyrate (VI), and the use of (VI) for preparing 1-methyl-3-difluoromethyl pyrazol-3-ylcarboxyates VII (VI) (VII) OR, FHC COOR. -
Hazardous Substances (Chemicals) Transfer Notice 2006
16551655 OF THURSDAY, 22 JUNE 2006 WELLINGTON: WEDNESDAY, 28 JUNE 2006 — ISSUE NO. 72 ENVIRONMENTAL RISK MANAGEMENT AUTHORITY HAZARDOUS SUBSTANCES (CHEMICALS) TRANSFER NOTICE 2006 PURSUANT TO THE HAZARDOUS SUBSTANCES AND NEW ORGANISMS ACT 1996 1656 NEW ZEALAND GAZETTE, No. 72 28 JUNE 2006 Hazardous Substances and New Organisms Act 1996 Hazardous Substances (Chemicals) Transfer Notice 2006 Pursuant to section 160A of the Hazardous Substances and New Organisms Act 1996 (in this notice referred to as the Act), the Environmental Risk Management Authority gives the following notice. Contents 1 Title 2 Commencement 3 Interpretation 4 Deemed assessment and approval 5 Deemed hazard classification 6 Application of controls and changes to controls 7 Other obligations and restrictions 8 Exposure limits Schedule 1 List of substances to be transferred Schedule 2 Changes to controls Schedule 3 New controls Schedule 4 Transitional controls ______________________________ 1 Title This notice is the Hazardous Substances (Chemicals) Transfer Notice 2006. 2 Commencement This notice comes into force on 1 July 2006. 3 Interpretation In this notice, unless the context otherwise requires,— (a) words and phrases have the meanings given to them in the Act and in regulations made under the Act; and (b) the following words and phrases have the following meanings: 28 JUNE 2006 NEW ZEALAND GAZETTE, No. 72 1657 manufacture has the meaning given to it in the Act, and for the avoidance of doubt includes formulation of other hazardous substances pesticide includes but -
OZO-L-CYCLOPBNTBNE. 1-CAEBOXYLATE and ETHYL 2-METHYL-3-OXOCYCLOPENTANECAKBOXYLATE
PART I THE SYNTHESES AND EEACTIONS OF METHYL 2-METHYL-^-OZO-l-CYCLOPBNTBNE. 1-CAEBOXYLATE AND ETHYL 2-METHYL-3-OXOCYCLOPENTANECAKBOXYLATE PAET II A STUDY OF THE REACTIONS OF GRIGNARD REAGENTS WITH ESTERS OF LEVULINIC ACID DISSERTATION Presented. In Partial Fulfillment of the Requirements for the Degree Doctor of Philosophy in the Graduate School of the Ohio State University By James Li McPherson, B.S., M.A, The Ohio State University 1955 Approved by: Adviser ACKNOWLEnXSMEWT It is a pleasure to express ray deep appreciation to Dr. Melvin S. Nevraan who suggested this problem, and whose advice and encouragement were an invaluable aid throughout this investigation, and to extend to the Upjohn Company, Kalamazoo, Michigan, ray sincere appreciation for a fellowship in connection with this work. il TABLE OF CONTENTS Aoknowledgeinent Part I The Syntheses and Beaotlons of Methyl S-raethyl-l-oxo-l-cyclopentene- 1-carhoxylate (IX) and ethyl 2-methyl~5-oxocyclopentanecarboxylate (Vl) Chapter Page I Introduction 1 II Synthesis 1. Discussion of Results 12 2. Flor Sheet (Fig. 5) 15 5. Diethyl 2-cyanc«3-taethylhutanedioate (ll) l6 k . Diethyl 2-cyano-2.-(2-oyanoethyl)-3- methylhutanedioate (ill) l8 5, Tfiethyl ^-metbyl-l, $,4-pentanetricarhoxylate (l?) 19 6 , Diethyl 2-methyl-3"Oxo«l,it— cyclopentane dicarhoxylate (v) 22 7, Ethyl 2~methyl-3-oxocyclopentanecar'boxylate (Vl) 2 k 8 , 2«Methyl*-3-'Oxo"l-cyclopentene-*l« carhoxylic acid (VIIl) 26 9* 2r^ethyl-3»-oxocyclopentaneoarh0xylic acid 29 10 0 Methyl 2p-methyl"3~oxo«l-cyclopentene" 1-carhoxylate (ix) 52 11. Ethyl 2-methyl~3'*oxor«l-cyclopentene" Imcarhoxylate (VIl) 55 III Reactions 1. -
Synthesis and Reactions of Novel Thienotetrahydroisoquinoline Compounds
Synthesis and reactions of novel thienotetrahydroisoquinoline compounds Remon M. Zaki*, Adel M. Kamal El-Dean, Shaban M. Radwan Chemistry Department, Faculty of Science, Assiut University, Assiut 71516, Egypt Síntesis y reacciones de nuevos compuestos de tienotetrahidroisoquinolina Síntesi i reaccions de nous derivats de tientetrahidroisoquinolina Recibido:2 de octubre de 2011; aceptado: 16 de febrero de 2012 RESUMEN for synthesis of triazepinopyrimido 10. Reaction of 1 with carbon disulfide in pyridine afforded the pyrimidinethione La cloroacetilación de 1-Aminocarboxamida 1 propor- 13 which underwent double Mannich reaction to give the cionó la cloroacetilamina 2 la cual experimentó el cierre novel thiadiazinopyrimido compound 14. Reaction of tet- del anillo al ser sometida a reflujo con anhídrido acético rahydroisoquinoline thione 15 with 2-chloromethylbenz- para proporcionar el derivado clorometilpirimido 3. Este imidazole followed by Thorpe-Zeigler cyclization to afford último compuesto experimenta reacciones de sustitución the aminobenzoimidazolyl 18 which proved its versatil- nucleofílica con varias aminas primarias y secundarias ity as starting material for synthesis of novel heterocyclic que, a través de la reacción de Mannich proporcionaron compounds 19-22. las imidazopirimidotienoisoquinolinas 5a-c. El compuesto 1 reacciona con anhídrido ftálico en ácido acético y DMF Keywords: Imidazole, Triazepine, Thiadiazine, Pyrimidine, para proporcionar phthalimido- e isoindolopymimidotieno- synthesis, reactions tetrahidroisoquinolinas -
Spectra Library Index Ichem/SDBS Raman Library
Ichem / SDBS Raman スタンダードライブラリー 株式会社 エス・ティ・ジャパン S p e c t r a L i b r a r y I n d e x (Ver. 40) Ichem / SDBS Raman Library ライブラリー名:ラマンスタンダードライブラリー 商品番号:60001-40 株式会社 エス・ティ・ジャパン 〒103-0014 東京都中央区日本橋蛎殻町 1-14-10 Tel: 03-3666-2561 Fax:03-3666-2658 http://www.stjapan.co.jp 1 【販売代理店】(株)テクノサイエンス Tel:043-206-0155 Fax:043-206-0188 https://www.techno-lab-co.jp/ Ichem / SDBS Raman スタンダードライブラリー 株式会社 エス・ティ・ジャパン ((1,2-DIETHYLETHYLENE)BIS(P-PHENYLENE))DIACETATE ((2-(3-BENZYLSULFONYL-4-METHYLCYCLOHEXYL)PROPYL)SULFONYLMETHYL)BENZENE ((2,4,6-TRIOXOHEXAHYDRO-5-PYRIMIDINYL)IMINO)DIACETIC ACID ((2-CARBOXYETHYL)IMINO)DIACETIC ACID ((2-HYDROXYETHYL)IMINO)DIACETIC ACID ((2-NITROBENZYL)IMINO)DIACETIC ACID ((2-SULFOETHYL)IMINO)DIACETIC ACID ((3-(1-BROMO-1-METHYLETHYL)-7-OXO-1,3,5-CYCLOHEPTATRIEN-1-YL)OXY)DIFLUOROBORANE ((N-BENZYLOXYCARBONYL-L-ISOLEUCYL)-L-PROLYL-L-PHENYLALANYL)-N(OMEGA)-NITRO-L-ARGININE 4-NITROBENZYL ESTER (-)-2-AMINO-1-BUTANOL (-)-2-AMINO-6-MERCAPTOPURINE RIBOSIDE (-)-6,8-P-MENTHADIEN-2-OL (-)-DIACETYL-L-TARTARIC ACID (-)-DIBENZOYL-L-TARTARIC ACID (-)-DI-P-ANISOYL-L-TARTARIC ACID (-)-DI-P-TOLUOYL-L-TARTARIC ACID (-)-KAURENE (-)-MENTHOL (-)-MYRTENOL (-)-N,N,N',N'-TETRAMETHYL-D-TARTARDIAMIDE (-)-N,N'-DIBENZYL-D-TARTRAMIDE (+)-1,3,3-TRIMETHYLNORBORNANE-2-ONE (+)-2-(2,4,5,7-TETRANITRO-9-FLUORENYLIDENEAMINOOXY)PROPIONIC ACID (+)-2-AMINO-1-BUTANOL (+)-2-PINENE (+)-3,9-DIBROMOCAMPHOR (+)-3-CARENE (+)-5-BROMO-2'-DEOXYURIDINE (+)-AMMONIUM 3-BROMO-8-CAMPHORSULFONATE (+)-CAMPHOR (+)-CAMPHOR OXIME (+)-CAMPHORIC ACID (+)-CATECHIN (+)-DI-P-ANISOYL-D-TARTARIC -
Nicolet Vapor Phase
Nicolet Vapor Phase Library Listing – 8,654 spectra This library is one the most comprehensive collections of vapor phase FT-IR spectra. It is an invaluable tool for scientist involved in investigations on gas phase materials. The Nicolet Vapor Phase Library contains 8654 FT-IR spectra of compounds measured in gas phase. Most spectra were acquired by the Sigma-Aldrich Co. using product samples. Additional spectra were collected by Hannover University, University of Wurzburg and Thermo Fisher Scientific applications scientists. Spectra were collected using sampling techniques including heated or room temperature gas cell or a heated light-pipe connected to the outlet of a gas chromatograph. Nicolet Vapor Phase Index Compound Name Index Compound Name 8402 ((1- 5457 (-)-8-Phenylmenthol; (-)-(1R,2S,5R)-5- Ethoxycyclopropyl)oxy)trimethylsilane Methyl-2-(2-phenyl-2-propyl)cyc 4408 (+)-1,3-Diphenylbutane 1095 (-)-Carveol, mixture of isomers; p- 4861 (+)-1-Bromo-2,4-diphenylbutane Mentha-6,8-dien-2-ol 2406 (+)-3-(Heptafluorobutyryl)camphor 3628 (-)-Diisopropyl D-tartrate 2405 (+)-3-(Trifluoroacetyl)camphor 1427 (-)-Limonene oxide, cis + trans; (-)-1,2- 281 (+)-3R-Isolimonene, trans-; (1R,4R)- Epoxy-4-isopropenyl-1-methyl (+)-p-Mentha-2,8-diene 1084 (-)-Menthol; [1R-(1a,2b,5a)]-(-)-2- 289 (+)-Camphene; 2,2-Dimethyl-3- Isopropyl-5-methylcyclohexanol methylenebicyclo[2.2.1]heptane 2750 (-)-Menthoxyacetic acid 3627 (+)-Diisopropyl L-tartrate 1096 (-)-Myrtanol, cis-; (1S,2R)-6,6- 2398 (+)-Fenchone; (+)-1,3,3- Dimethylbicyclo[3.1.1]heptane-2-metha -
Air Toxics Report
Toxicological Advisory Committee AIR TOXICS REPORT Prepared for State of Vermont Agency of Natural Resources February, 1998 Table of Contents I. Executive Summary 1 II. Review of Hazardous Ambient Air Standards 7 III. Measurement of Hazardous Air Contaminants in 19 Ambient Air IV. Priority Compounds 27 V. Management Options 56 VI. Risk Issues 58 VII. Future Actions 63 Appendix A Category I - Algorithm and Tables Appendix B Category II and Category III Tables Appendix C Air Monitoring Data - Tables Appendix D Research Status Report-Mercury Deposition and Effects in the Lake Champlain Basin Appendix E The Toxicological Advisory Committee List of Acronyms ACGIH - American Conference of Governmental Industrial Hygienists AEGL - Acute Exposure Guideline Level Agency - Vermont Agency of Natural Resources Category I - A contaminant that is known or suspected to be a carcinogen. Category II - A contaminant that is a noncarcinogen with potential/systemic effects due to long term exposure. Category III - A contaminant that is a noncarcinogen considered to have primarily short term irritant effects. CPF - Cancer Potency Factor CPFi - Inhalation Cancer Potency Factor CPFo- Oral Cancer Potency Factor Committee - Toxicological Advisory Committee HAAS - Hazardous Ambient Air Standard HEAST - Health Effects Summary Tables, US EPA IARC - International Agency for Research on Cancer IRIS - Integrated Risk Information System database, US EPA MDL - Method Detection Limit NCI - National Cancer Institute NIOSH - National Institute for Occupational Safety and Health NTP - National Toxicological Program OSHA - United States Department of Labor Occupational Safety and Health Administration PAH - Polynuclear Aromatic Hydrocarbons PCB - Polychlorinated Biphenyl PCDD/PCDF - Polychlorinated Dibenzo-P-Dioxins/Furans PEL - Permissible Exposure Limit, derived by OSHA REL - Recommended Exposure Limit, derived by NIOSH RfC - Inhalation Reference Concentration TLV - Threshold Limit Value, derived by ACGIH US EPA - United States Environmental Protection Agency VOC - Volatile Organic Compound I. -
Ep 3043784 B9
(19) *EP003043784B9* (11) EP 3 043 784 B9 (12) CORRECTED EUROPEAN PATENT SPECIFICATION (15) Correction information: (51) Int Cl.: Corrected version no 1 (W1 B1) A61K 31/085 (2006.01) C07C 255/54 (2006.01) (2006.01) Corrections, see C07D 213/85 Claims EN 1, 8, 10 (86) International application number: (48) Corrigendum issued on: PCT/US2014/054375 20.11.2019 Bulletin 2019/47 (87) International publication number: (45) Date of publication and mention WO 2015/035223 (12.03.2015 Gazette 2015/10) of the grant of the patent: 15.05.2019 Bulletin 2019/20 (21) Application number: 14842085.4 (22) Date of filing: 05.09.2014 (54) ARYL ETHERS AND USES THEREOF ARYLETHER UND VERWENDUNGEN DAVON ARYLÉTHERS ET UTILISATIONS DE CEUX-CI (84) Designated Contracting States: • RIZZI, James P. AL AT BE BG CH CY CZ DE DK EE ES FI FR GB Irving, TX 75063 (US) GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO • SCHLACHTER, Stephen, T. PL PT RO RS SE SI SK SM TR Dallas, TX 75208 (US) • WALLACE, Eli, M. (30) Priority: 09.09.2013 US 201361875674 P Richardson, TX 75080 (US) 11.04.2014 US 201461978421 P • WANG, Bin Dallas, TX 75229 (US) (43) Date of publication of application: • WEHN, Paul 20.07.2016 Bulletin 2016/29 Dallas, TX 75205 (US) • XU, Rui (60) Divisional application: Dallas, TX 75205 (US) 18185557.8 / 3 417 851 • YANG, Hanbiao 18185565.1 / 3 417 852 Coppell, TX 75019 (US) 19192594.0 (74) Representative: Mewburn Ellis LLP (73) Proprietor: Peloton Therapeutics, Inc.