Hazardous Substances (Chemicals) Transfer Notice 2006
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EPA Handbook: Optical and Remote Sensing for Measurement and Monitoring of Emissions Flux of Gases and Particulate Matter
EPA Handbook: Optical and Remote Sensing for Measurement and Monitoring of Emissions Flux of Gases and Particulate Matter EPA 454/B-18-008 August 2018 EPA Handbook: Optical and Remote Sensing for Measurement and Monitoring of Emissions Flux of Gases and Particulate Matter U.S. Environmental Protection Agency Office of Air Quality Planning and Standards Air Quality Assessment Division Research Triangle Park, NC EPA Handbook: Optical and Remote Sensing for Measurement and Monitoring of Emissions Flux of Gases and Particulate Matter 9/1/2018 Informational Document This informational document describes the emerging technologies that can measure and/or identify pollutants using state of the science techniques Forward Optical Remote Sensing (ORS) technologies have been available since the late 1980s. In the early days of this technology, there were many who saw the potential of these new instruments for environmental measurements and how this technology could be integrated into emissions and ambient air monitoring for the measurement of flux. However, the monitoring community did not embrace ORS as quickly as anticipated. Several factors contributing to delayed ORS use were: • Cost: The cost of these instruments made it prohibitive to purchase, operate and maintain. • Utility: Since these instruments were perceived as “black boxes.” Many instrument specialists were wary of how they worked and how the instruments generated the values. • Ease of use: Many of the early instruments required a well-trained spectroscopist who would have to spend a large amount of time to setup, operate, collect, validate and verify the data. • Data Utilization: Results from path integrated units were different from point source data which presented challenges for data use and interpretation. -
Transport of Dangerous Goods
ST/SG/AC.10/1/Rev.16 (Vol.I) Recommendations on the TRANSPORT OF DANGEROUS GOODS Model Regulations Volume I Sixteenth revised edition UNITED NATIONS New York and Geneva, 2009 NOTE The designations employed and the presentation of the material in this publication do not imply the expression of any opinion whatsoever on the part of the Secretariat of the United Nations concerning the legal status of any country, territory, city or area, or of its authorities, or concerning the delimitation of its frontiers or boundaries. ST/SG/AC.10/1/Rev.16 (Vol.I) Copyright © United Nations, 2009 All rights reserved. No part of this publication may, for sales purposes, be reproduced, stored in a retrieval system or transmitted in any form or by any means, electronic, electrostatic, magnetic tape, mechanical, photocopying or otherwise, without prior permission in writing from the United Nations. UNITED NATIONS Sales No. E.09.VIII.2 ISBN 978-92-1-139136-7 (complete set of two volumes) ISSN 1014-5753 Volumes I and II not to be sold separately FOREWORD The Recommendations on the Transport of Dangerous Goods are addressed to governments and to the international organizations concerned with safety in the transport of dangerous goods. The first version, prepared by the United Nations Economic and Social Council's Committee of Experts on the Transport of Dangerous Goods, was published in 1956 (ST/ECA/43-E/CN.2/170). In response to developments in technology and the changing needs of users, they have been regularly amended and updated at succeeding sessions of the Committee of Experts pursuant to Resolution 645 G (XXIII) of 26 April 1957 of the Economic and Social Council and subsequent resolutions. -
United States Patent (19) (11) 4,161,571 Yasui Et Al
United States Patent (19) (11) 4,161,571 Yasui et al. 45 Jul. 17, 1979 (54) PROCESS FOR PRODUCTION OF THE 4,080,493 3/1978 Yasui et al. .......................... 260/879 MALE CANHYDRDE ADDUCT OF A 4,082,817 4/1978 Imaizumi et al. ...................... 526/46 LIQUID POLYMER 4,091,198 5/1978 Smith ..................................... 526/56 75 Inventors: Seimei Yasui, Takarazuka; Takao FOREIGN PATENT DOCUMENTS Oshima, Sonehigashi, both of Japan 2262677 2/1975 France ....................................... 526/56 73) Assignee: Sumitomo Chemical Company, 44-1989 1/1969 Japan ......................................... 526/56 Limited, Osaka, Japan Primary Examiner-William F. Hamrock Attorney, Agent, or Firm-Birch, Stewart, Kolasch and 21 Appl. No.: 843,311 Birch 22 Filed: Oct. 18, 1977 57 ABSTRACT Related U.S. Application Data A process for production of the maleic anhydride ad duct of a liquid polymer having a maleic anhydride 62 Division of Ser. No. 733,914, Oct. 19, 1976, Pat, No. addition amount of 2 to 70% by weight, which com 4,080,493. prises reacting a liquid polymer having a molecular 51 Int. C.’................................................ CO8F 8/46 weight of 150 to 5,000 and a viscosity of 2 to 50,000 cp (52) U.S. C. ...................................... 526/90; 526/192; at 30 C. in the presence of at least one compound, as a 526/209; 526/213; 526/193; 526/195; 526/226; gelation inhibitor, selected from the group consisting of 526/233; 526/237; 526/238; 526/272; 525/285; imidazoles, thiazoles, metallic salts of mercapto 525/249; 525/251; 525/255; 525/245; 525/248 thiazoles, urea derivatives, naphthylamines, nitrosa (58) Field of Search ................ -
Aldrich Organometallic, Inorganic, Silanes, Boranes, and Deuterated Compounds
Aldrich Organometallic, Inorganic, Silanes, Boranes, and Deuterated Compounds Library Listing – 1,523 spectra Subset of Aldrich FT-IR Library related to organometallic, inorganic, boron and deueterium compounds. The Aldrich Material-Specific FT-IR Library collection represents a wide variety of the Aldrich Handbook of Fine Chemicals' most common chemicals divided by similar functional groups. These spectra were assembled from the Aldrich Collections of FT-IR Spectra Editions I or II, and the data has been carefully examined and processed by Thermo Fisher Scientific. Aldrich Organometallic, Inorganic, Silanes, Boranes, and Deuterated Compounds Index Compound Name Index Compound Name 1066 ((R)-(+)-2,2'- 1193 (1,2- BIS(DIPHENYLPHOSPHINO)-1,1'- BIS(DIPHENYLPHOSPHINO)ETHAN BINAPH)(1,5-CYCLOOCTADIENE) E)TUNGSTEN TETRACARBONYL, 1068 ((R)-(+)-2,2'- 97% BIS(DIPHENYLPHOSPHINO)-1,1'- 1062 (1,3- BINAPHTHYL)PALLADIUM(II) CH BIS(DIPHENYLPHOSPHINO)PROPA 1067 ((S)-(-)-2,2'- NE)DICHLORONICKEL(II) BIS(DIPHENYLPHOSPHINO)-1,1'- 598 (1,3-DIOXAN-2- BINAPH)(1,5-CYCLOOCTADIENE) YLETHYNYL)TRIMETHYLSILANE, 1140 (+)-(S)-1-((R)-2- 96% (DIPHENYLPHOSPHINO)FERROCE 1063 (1,4- NYL)ETHYL METHYL ETHER, 98 BIS(DIPHENYLPHOSPHINO)BUTAN 1146 (+)-(S)-N,N-DIMETHYL-1-((R)-1',2- E)(1,5- BIS(DI- CYCLOOCTADIENE)RHODIUM(I) PHENYLPHOSPHINO)FERROCENY TET L)E 951 (1,5-CYCLOOCTADIENE)(2,4- 1142 (+)-(S)-N,N-DIMETHYL-1-((R)-2- PENTANEDIONATO)RHODIUM(I), (DIPHENYLPHOSPHINO)FERROCE 99% NYL)ETHYLAMIN 1033 (1,5- 407 (+)-3',5'-O-(1,1,3,3- CYCLOOCTADIENE)BIS(METHYLD TETRAISOPROPYL-1,3- IPHENYLPHOSPHINE)IRIDIUM(I) -
Ep 2508506 A1
(19) & (11) EP 2 508 506 A1 (12) EUROPEAN PATENT APPLICATION (43) Date of publication: (51) Int Cl.: 10.10.2012 Bulletin 2012/41 C07C 67/343 (2006.01) C07C 227/08 (2006.01) C07F 5/02 (2006.01) C07C 229/34 (2006.01) (21) Application number: 11161611.6 (22) Date of filing: 08.04.2011 (84) Designated Contracting States: (72) Inventor: The designation of the inventor has not AL AT BE BG CH CY CZ DE DK EE ES FI FR GB yet been filed GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR (74) Representative: Kunic Tesovic, Barbara Designated Extension States: Lek Pharmaceuticals d.d. BA ME Sandoz Development Center Slovenia - Patents Verovskova 57 (71) Applicant: LEK Pharmaceuticals d.d. 1526 Ljubljana (SI) 1526 Ljubljana (SI) (54) Preparation of sitagliptin intermediates (57) The invention relates to the preparation of chiral compounds, in particular to the preparation of chiral compounds which may be used as intermediates for the preparation of anti-diabetic agents, preferably sitagliptin. EP 2 508 506 A1 Printed by Jouve, 75001 PARIS (FR) EP 2 508 506 A1 Description Field of the Intention 5 [0001] The present invention relates to the preparation of chiral compounds, in particular to the preparation of chiral compounds which may be used as intermediates for the preparation of anti-diabetic agents, preferably sitagliptin. Background prior art 10 [0002] Type II diabetes mellitus (T2DM) is a global epidemic. Therefore, the research is oriented in the development of selective inhibitors of the enzyme DPP-IV as a promising new treatment for the type II diabetes. -
The Synthesis of 1,2-Azaphospholes, 1,2-Azaphosphorines and 1,2-Azaphosphepines
The Free Internet Journal Review for Organic Chemistry Archive for Arkivoc 2020, i, 472-498 Organic Chemistry The synthesis of 1,2-azaphospholes, 1,2-azaphosphorines and 1,2-azaphosphepines Noha M. Hassanin,a Tarik E. Ali,b,a* Mohammed A. Assiri,b Hafez M. Elshaaer,a and Somaia M. Abdel-Kariema a Department of Chemistry, Faculty of Education, Ain Shams University, Roxy, Cairo, Egypt b Department of Chemistry, Faculty of Science, King Khalid University, Abha, Saudi Arabia Email: [email protected], [email protected] Received 06-28-2020 Accepted 08-26-2020 Published online 10-22-2020 Abstract 1,2-Azaphospholes, 1,2-azaphosphorines and 1,2-azaphosphepines are prominent phosphorus heterocycles and are of interest due to their potent pharmacological activities. In this review, we provide the available literature data on the synthesis of 1,2-azaphospholes, 1,2-azaphosphorines and 1,2-azaphosphepines. Keywords: 1,2-azaphospholes, 1,2-azaphosphorines, 1,2-azaphosphepines, phosphorus heterocycles DOI: https://doi.org/10.24820/ark.5550190.p011.280 Page 472 ©AUTHOR(S) Arkivoc 2020, i, 472-498 Hassanin, N. M. et al. Table of Contents 1. Introduction 2. Synthetic Methods for Functionalized 1,2-Azaphosphole Derivatives 2.1 Cyclization of ethyl N-methyl-3-bromopropylphosphonamidate with NaH 2.2 Cyclization of -aminophosphorus compounds with bases 2.3 Reaction of methyleneaminophosphanes with activated alkenes and alkynes 2.4 Cyclization of 2-[2-(t-butylimino)cyclohexyl]acetonitrile with PCl3 2.5 Cyclization of 2-imino-2H-chromene-3-carboxamide -
Synthesis of C2-Symmetric P-Chiral Bis(Phosphine Borane)
Synthesis of C2-symmetric P-chiral bis(phosphine borane)s and their application in rhodium(I) catalyzed asymmetric transformation by Holly Ann Heath A dissertation submitted in partial fulfillment of the requirements for the degree of Doctor of Philosophy in Chemistry Montana State University © Copyright by Holly Ann Heath (2001) Abstract: A new development for the synthesis C2-Synnnetric P-Chiral Bis(phosphine borane) ligands is reported, These ligands are based on the asymmetric induction of prochiral phosphine ligands with organolithium/chiral diamine complexes. These ligands have been evaluated in asymmetric rhodium(I) catalyzed hydrogenation and [4 + 2] cycloisomerization reactions. Enantiomeric excesses as high as 99% were obtained for ene-diene cycloadditions. Synthesis of C2-Symmetric P-Chiral Bis(phosphine borane)s and Their Application in Rhodium(I) Catalyzed Asymmetric Transformation by Holly Ann Heath A dissertation submitted in partial fulfillment of the requirements for the degree of Doctor of Philosophy in Chemistry Montana State University Bozeman, Montana March 2001 ii APPROVAL of a dissertation submitted by Holly Ann Heath This dissertation has been read by each member of the dissertation committee and has been found to be satisfactory regarding content, English usage, format, citations, bibliographic style, and consistency, and is ready for submission to the College of Graduate Studies. Dr. Thomas Livinghouse < Chairperson, Graduate Committee Date Approved for the Department of Chemistry Dr. Paul A. Grieco Department Head Approved for the College of Graduate Studies Dr. Bruce R. McLeod Graduate Dean Date iii STATEMENT OF PERMISSION TO USE In presenting this dissertation .in partial fulfillment of the requirements for a doctoral degree at Montana State University-Bozeman, I agree that the Library shall make it available to borrowers under rules of the Library. -
Alphabetical Index of Substances and Articles
ALPHABETICAL INDEX OF SUBSTANCES AND ARTICLES - 355 - NOTES TO THE INDEX 1. This index is an alphabetical list of the substances and articles which are listed in numerical order in the Dangerous Goods List in Chapter 3.2. 2. For the purpose of determining the alphabetical order the following information has been ignored even when it forms part of the proper shipping name: numbers; Greek letters; the abbreviations “sec” and “tert”; and the letters “N” (nitrogen), “n” (normal), “o” (ortho) “m” (meta), “p” (para) and “N.O.S.” (not otherwise specified). 3. The name of a substance or article in block capital letters indicates a proper shipping name. 4. The name of a substance or article in block capital letters followed by the word “see” indicates an alternative proper shipping name or part of a proper shipping name (except for PCBs). 5. An entry in lower case letters followed by the word “see” indicates that the entry is not a proper shipping name; it is a synonym. 6. Where an entry is partly in block capital letters and partly in lower case letters, the latter part is considered not to be part of the proper shipping name. 7. A proper shipping name may be used in the singular or plural, as appropriate, for the purposes of documentation and package marking. - 356 - INDEX Name and description Class UN No. Name and description Class UN No. Accumulators, electric, see 4.3 3292 Acid mixture, nitrating acid, see 8 1796 8 2794 8 2795 Acid mixture, spent, nitrating acid, see 8 1826 8 2800 8 3028 Acraldehyde, inhibited, see 6.1 1092 ACETAL 3 1088 -
Hexafluorosilicic Acid
Sodium Hexafluorosilicate [CASRN 16893-85-9] and Fluorosilicic Acid [CASRN 16961-83-4] Review of Toxicological Literature October 2001 Sodium Hexafluorosilicate [CASRN 16893-85-9] and Fluorosilicic Acid [CASRN 16961-83-4] Review of Toxicological Literature Prepared for Scott Masten, Ph.D. National Institute of Environmental Health Sciences P.O. Box 12233 Research Triangle Park, North Carolina 27709 Contract No. N01-ES-65402 Submitted by Karen E. Haneke, M.S. (Principal Investigator) Bonnie L. Carson, M.S. (Co-Principal Investigator) Integrated Laboratory Systems P.O. Box 13501 Research Triangle Park, North Carolina 27709 October 2001 Toxicological Summary for Sodium Hexafluorosilicate [16893-85-9] and Fluorosilicic Acid [16961-83-4] 10/01 Executive Summary Nomination Sodium hexafluorosilicate and fluorosilicic acid were nominated for toxicological testing based on their widespread use in water fluoridation and concerns that if they are not completely dissociated to silica and fluoride in water that persons drinking fluoridated water may be exposed to compounds that have not been thoroughly tested for toxicity. Nontoxicological Data Analysis and Physical-Chemical Properties Analytical methods for sodium hexafluorosilicate include the lead chlorofluoride method (for total fluorine) and an ion-specific electrode procedure. The percentage of fluorosilicic acid content for water supply service application can be determined by the specific-gravity method and the hydrogen titration method. The American Water Works Association (AWWA) has specified that fluorosilicic acid contain 20 to 30% active ingredient, a maximum of 1% hydrofluoric acid, a maximum of 200 mg/kg heavy metals (as lead), and no amounts of soluble mineral or organic substance capable of causing health effects. -
Simultaneous Determination of Some Antiprotozoal Drugs in Different
Abdelaleem and Abdelwahab Chemistry Central Journal 2012, 6:27 http://journal.chemistrycentral.com/content/6/1/27 RESEARCHARTICLE Open Access Simultaneous determination of some antiprotozoal drugs in different combined dosage forms by mean centering of ratio spectra and multivariate calibration with model updating methods Eglal A Abdelaleem and Nada S Abdelwahab* Abstract Background: Metronidazole (MET) and Diloxanide Furoate (DF), act as antiprotozoal drugs, in their ternary mixtures with Mebeverine HCl (MEH), an effective antispasmodic drug. This work concerns with the development and validation of two simple, specific and cost effective methods mainly for simultaneous determination of the proposed ternary mixture. In addition, the developed multivariate calibration model has been updated to determine Metronidazole benzoate (METB) in its binary mixture with DF in Dimetrol® suspension. Results: Method (I) is the mean centering of ratio spectra spectrophotometric method (MCR) that depends on using the mean centered ratio spectra in two successive steps that eliminates the derivative steps and therefore the signal to noise ratio is enhanced. The developed MCR method has been successfully applied for determination of MET, DF and MEH in different laboratory prepared mixtures and in tablets. Method (II) is the partial least square (PLS) multivariate calibration method that has been optimized for determination of MET, DF and MEH in Dimetrol ® tablets and by updating the developed model, it has been successfully used for prediction of binary mixtures of DF and Metronidazole Benzoate ester (METB) in Dimetrol ® suspension with good accuracy and precision without reconstruction of the calibration set. Conclusion: The developed methods have been validated; accuracy, precision and specificity were found to be within the acceptable limits. -
Nomination Background: Methyl Trans
' 7/?1 Methyl styryl ketone 122-57-6 NTP NOMINATION HISTORY AND REVIEW A. Nomination History 1. Nomination Source: NCI 2. Recommendations: -Comparative toxicity studies with methyl vinyl ketone -Metabolism -Carcinogenicity 3. Rationale/Remarks: -Potential for widespread human exposure -Nominated as a result of a class study of a,~-unsaturated ketones -Flavoring and fragrance additive -Natural product -Environmental pollutant -Mutagenic in Salmonella 4. Priority: -High for toxicity studies -Moderate for carcinogenicity s. Date of Nomination: July 1994 B. Interagency Committee for Chemical Evaluation and Coordination Review 1. Date of Review: 2. Recommendations: 3. Priority: 4. NTP Chemical Selection Principles: 5. Rationale/Remarks: 122-57-6 Methyl styryl ketone SUMMARY OF DATA FOR CHEMICAL SELECTION CHEMICAL IDENTIFICATION CAS Registry Number: 122-57-6 Chemical Abstracts Name: 3-Buten-2-one, 4-phenyl- (SCI, 9CI) Svnonvms and Trade Names: Acetocinnamone; benzalacetone; benzylideneacetone; methyl 2 phenylvinyl ketone; methyl styryl ketone; methyl ~-styryl ketone; 4 phenylbutenone; 4-phenyl-3-butene-2-one; 2-phenylvinyl methyl ketone; styryl methyl ketone; MSK FEMA Number: 2881 Related isomers CAS Registry Number: 937-53-1 Chemica] Abstracts Name: 3-Buten-2-one, 4-phenyl-, (Z)- (SCI, 9CI) Synonvms and Trade Names: cis -4-Phenyl-3-buten-2-one; cis -benzalacetone; cis benzylideneacetone; cis-methyl styryl ketone CAS Registry Number: 1896-62-4 Chemical Abstracts Name: 3-Buten-2-one, 4-phenyl-, (E)- (SCI, 9CI) Synonyms and Trade Names: trans-4-Phenyl-3-buten-2-one; trans-benzalacetone; trans benzylideneacetone; trans-methyl styryl ketone; TPBO Structure. Molecular Formula. and Molecular WeiKbt 0 II H•CHCCH3 Mol. wt.: 146.19 Chemical and Phvsical Properties (from Aldrich Chemical Co., 1993, 1994; Budavari, 1989) Description: White to yellow solid with a sweet, pungent, creamy, floral odor Prepared for NCI by Technical Resources, Inc. -
Economic Commission for Europe Inland Transport
ECONOMIC COMMISSION FOR EUROPE INLAND TRANSPORT COMMITTEE INF.6 Working Party on the Transport of Dangerous Goods Joint Meeting of the RID Safety Committee and the Working Party on the Transport of Dangerous Goods (Geneva, 1-10 September 2003) Harmonization with the UN Recommendations on the Transport of Dangerous Goods Bulk containers Transmitted by the Government of the United Kingdom 1. Introduction New provisions for bulk containers from the UN Model Regulations are being proposed for inclusion in RID/ADR based on text prepared by the UN Secretariat and as discussed at the ad hoc Working Group on the Harmonization of RID/ADR/ADN with the UN Recommendations on the Transport of Dangerous Goods that met from 26-28 May 2003. The results of the discussions on this subject are recorded in paragraphs 39 to 46 of the report of the ad hoc Working Group TRANS/WP.15/AC.1/2003/56 and the proposed text for inclusion in RID/ADR in the relevant parts of Addendum 1 to 7 of 2003/56, in particular a new chapter 6.11 and a modified chapter 7.3. 2. Proposal and Justification A new chapter 6.11, reflecting UN chapter 6.8, is contained in 2003/56 Add 6 dealing with the requirements for the design, construction, inspection and testing of bulk containers and new UN chapter 4.3 dealing with the use of bulk containers has been integrated into a modified chapter 7.3 contained in 2003/56 Add 7. Now that there are comprehensive provisions for bulk containers developed at UN level, the UK believes as reflected in paragraph 43 of 2003/56, that these should now apply to carriage in bulk in RID/ADR rather than have two separate systems based on the provisions for bulk containers in UN and the existing provisions in RID/ADR.