Touro Scholar NYMC Faculty Publications Faculty 4-1-2018 Perioperative Implication of the Endothelial Glycocalyx Jong Wook Song Michael S. Goligorsky New York Medical College Follow this and additional works at: https://touroscholar.touro.edu/nymc_fac_pubs Part of the Medicine and Health Sciences Commons Recommended Citation Song, J., & Goligorsky, M. (2018). Perioperative Implication of the Endothelial Glycocalyx. Korean Journal of Anesthesiology, 71 (2), 92-102. https://doi.org/10.4097/kjae.2018.71.2.92 This Article is brought to you for free and open access by the Faculty at Touro Scholar. It has been accepted for inclusion in NYMC Faculty Publications by an authorized administrator of Touro Scholar. For more information, please contact
[email protected]. Review Article pISSN 2005-6419 • eISSN 2005-7563 KJA Perioperative implication of the Korean Journal of Anesthesiology endothelial glycocalyx Jong Wook Song1,* and Michael S. Goligorsky2,* 1Department of Anesthesiology and Pain Medicine, Yonsei University College of Medicine, Seoul, Korea, 2Renal Research Institute and Departments of Medicine, Pharmacology, and Physiology, New York Medical College, Valhalla, NY, USA The endothelial glycocalyx (EG) is a gel-like layer lining the luminal surface of healthy vascular endothelium. Recent- ly, the EG has gained extensive interest as a crucial regulator of endothelial funtction, including vascular permeability, mechanotransduction, and the interaction between endothelial and circulating blood cells. The EG is degraded by vari- ous enzymes and reactive oxygen species upon pro-inflammatory stimulus. Ischemia-reperfusion injury, oxidative stress, hypervolemia, and systemic inflammatory response are responsible for perioperative EG degradation. Perioperative damage of the EG has also been demonstrated, especially in cardiac surgery.