molecules Article Verbascoside-Rich Abeliophyllum distichum Nakai Leaf Extracts Prevent LPS-Induced Preterm Birth Through Inhibiting the Expression of Proinflammatory Cytokines from Macrophages and the Cell Death of Trophoblasts Induced by TNF-α Ho Won Kim 1, A-Reum Yu 1, Minji Kang 2, Nak-Yun Sung 3 , Byung Soo Lee 3 , Sang-Yun Park 3 , In-Jun Han 3, Dong-Sub Kim 3 , Sang-Muk Oh 4, Young Ik Lee 5, Gunho Won 6, Sung Ki Lee 7,* and Jong-Seok Kim 1,* 1 Myunggok Medical Research Institute, College of Medicine, Konyang University, Daejeon 35365, Korea;
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[email protected] (A.-R.Y.) 2 Department of Medical Science, Chungnam National University, Daejeon 35365, Korea;
[email protected] 3 Division of Natural Product Research, Korea Prime Pharmacy CO. LTD., Jeonnam 58144, Korea;
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[email protected] (D.-S.K.) 4 Department of Biochemistry, College of Medicine, Konyang University, Daejeon 35365, Korea;
[email protected] 5 Industrial Bioresource Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon 35365, Korea;
[email protected] 6 Centers for Disease Control & Prevention National Institute of Health 187, Chungcheongbuk-do 28159, Korea;
[email protected] 7 Department of Obstetrics and Gynecology, Konyang University Hospital, Daejeon 35365, Korea * Correspondence:
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[email protected] (J.-S.K.); Tel.: +82-42-600-9114 (S.K.L.); +82-42-600-8648 (J.-S.K.) Academic Editors: Maurizio Battino, Jesus Simal-Gandara and Esra Capanoglu Received: 2 September 2020; Accepted: 5 October 2020; Published: 7 October 2020 Abstract: Background: Preterm birth is a known leading cause of neonatal mortality and morbidity.