GPR77 Antibody Cat. No.: 60-836

GPR77 Antibody

Specifications

HOST SPECIES: Rabbit

SPECIES REACTIVITY: Human

This GPR77 antibody is generated from rabbits immunized with a KLH conjugated IMMUNOGEN: synthetic peptide between 297-325 amino acids from the C-terminal region of human GPR77.

TESTED APPLICATIONS: WB

APPLICATIONS: For WB starting dilution is: 1:1000

PREDICTED MOLECULAR 36 kDa WEIGHT:

Properties

This antibody is purified through a protein A column, followed by peptide affinity PURIFICATION: purification.

CLONALITY: Polyclonal

ISOTYPE: Rabbit Ig

CONJUGATE: Unconjugated

September 29, 2021 1 https://www.prosci-inc.com/gpr77-antibody-60-836.html PHYSICAL STATE: Liquid

BUFFER: Supplied in PBS with 0.09% (W/V) sodium azide.

CONCENTRATION: batch dependent

Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies STORAGE CONDITIONS: care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Additional Info

OFFICIAL SYMBOL: C5AR2

C5a anaphylatoxin chemotactic receptor 2, Complement component 5a receptor 2, G- ALTERNATE NAMES: protein coupled receptor 77, C5AR2, C5L2, GPR77

ACCESSION NO.: Q9P296

PROTEIN GI NO.: 20137533

GENE ID: 27202

USER NOTE: Optimal dilutions for each application to be determined by the researcher.

Background and References

The anaphylatoxins C3a (see MIM 120700), C4a (see MIM 120810), and C5a are cationic fragments generated during the complement cascade that participate in host defense. In the case of inappropriate complement activation, anaphylatoxins may be involved in BACKGROUND: autoimmunity and sepsis. C5L2 is coexpressed with the C5a receptor, C5AR (C5R1; MIM 113995), on polymorphonuclear neutrophils and may modulate C5AR activity (Gerard et al., 2005 [PubMed 16204243]).

REFERENCES: 1) Bamberg, C.E., et al. J. Biol. Chem. 285(10):7633-7644(2010)

2) Cui, W., et al. Mol. Immunol. 46(16):3207-3217(2009)

3) Cui, W., et al. Mol. Immunol. 46(15):3086-3098(2009)

4) Scola, A.M., et al. Mol. Immunol. 46(6):1149-1162(2009)

ANTIBODIES FOR RESEARCH USE ONLY.

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