GPR77 Antibody Cat. No.: 60-836 GPR77 Antibody Specifications HOST SPECIES: Rabbit SPECIES REACTIVITY: Human This GPR77 antibody is generated from rabbits immunized with a KLH conjugated IMMUNOGEN: synthetic peptide between 297-325 amino acids from the C-terminal region of human GPR77. TESTED APPLICATIONS: WB APPLICATIONS: For WB starting dilution is: 1:1000 PREDICTED MOLECULAR 36 kDa WEIGHT: Properties This antibody is purified through a protein A column, followed by peptide affinity PURIFICATION: purification. CLONALITY: Polyclonal ISOTYPE: Rabbit Ig CONJUGATE: Unconjugated September 29, 2021 1 https://www.prosci-inc.com/gpr77-antibody-60-836.html PHYSICAL STATE: Liquid BUFFER: Supplied in PBS with 0.09% (W/V) sodium azide. CONCENTRATION: batch dependent Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies STORAGE CONDITIONS: care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. Additional Info OFFICIAL SYMBOL: C5AR2 C5a anaphylatoxin chemotactic receptor 2, Complement component 5a receptor 2, G- ALTERNATE NAMES: protein coupled receptor 77, C5AR2, C5L2, GPR77 ACCESSION NO.: Q9P296 PROTEIN GI NO.: 20137533 GENE ID: 27202 USER NOTE: Optimal dilutions for each application to be determined by the researcher. Background and References The anaphylatoxins C3a (see MIM 120700), C4a (see MIM 120810), and C5a are cationic fragments generated during the complement cascade that participate in host defense. In the case of inappropriate complement activation, anaphylatoxins may be involved in BACKGROUND: autoimmunity and sepsis. C5L2 is coexpressed with the C5a receptor, C5AR (C5R1; MIM 113995), on polymorphonuclear neutrophils and may modulate C5AR activity (Gerard et al., 2005 [PubMed 16204243]). REFERENCES: 1) Bamberg, C.E., et al. J. Biol. Chem. 285(10):7633-7644(2010) 2) Cui, W., et al. Mol. Immunol. 46(16):3207-3217(2009) 3) Cui, W., et al. Mol. Immunol. 46(15):3086-3098(2009) 4) Scola, A.M., et al. Mol. Immunol. 46(6):1149-1162(2009) ANTIBODIES FOR RESEARCH USE ONLY. For additional information, visit ProSci's Terms & Conditions Page. September 29, 2021 2 https://www.prosci-inc.com/gpr77-antibody-60-836.html.