peptide Dopamine Cysteinyl leukotriene Cholecystokinin Angiotensin Anaphylatoxin Adrenoceptor ADP/UDP-glucose Bradykinin Ghrelin/Motilin Galanin FMLP-related Endothelin Eicosanoid Duff Chemokine Cannabinoid Bombesin Ap A A ( A muscarinic drenomedullin denosine cet elin y y lcholine
) Family ls ls CasA ls ClassB ClassA ClassA ClassA Class A DB 0HM*rA 0 T1 9 H,M 192 HTR1F M 106 *MrgA3 H,M 20 ADRB1 GR17 , P1W18H*P4 4 , RC 3 , Z646H,M 406 FZD6 H,M 331 *RDC1 H,M 244 *GPR49 H 158 OPN1LW H,M 72 *GPR81 H7 1HMOR117H,M 157 OPRL1 H,M 71 *HM74 YL26 , PR 4 , T1 235 *TA12 H,M 149 PPYR1 H, 64 H,M 63 DRD1 CYSLT2 P8 2HMLBR 8HMPR1 8 MS 7 , ER 5 H H,M 354 137 MC5R *EMR2 M H,M 51 271 *CMKBR1L2 *MAS1 H 191 HTR1E H 184 P2RY11 H,M M 179 H,M 105 177 F2RL3 *MrgA2 F2RL1 H 99 H,M 98 MRGX1 LTB4R2 H,M H,M 93 19 H,M 91 ADRA2C FSHR HRH3 H,M 13 H,M 12 H,M 11 *GPR87 GPR86 GPR105 H,M 7 H,M 5 ADORA2A CHRM5 LR 4HM*P5 4 , A126HM*GC1 1 , R232H, 392 GRM2 H, 386 GPR51 H,M 313 *HGPCR19 H, 309 H,M 307 *GPR92 *GPR88 H,M M 226 78 FPR-RS1 TAR1 M 222 H,M 220 TRHR2 TACR3 H, 68 H,M 140 DRD5 *GPR50 H,M H,M 136 H,M 135 134 MC4R MC3R MC2R H,M 55 H,M 54 IL8RB IL8RA H,M M 49 H 50 48 H,M *CMKBR1L1 47 CCBP2 *CCRL2 CCRL1 DAA1 , RX 0 G816HM*2523H,M 273 *P2Y5 H,M 186 LGR8 H H 101 100 MRGX3 MRGX2 H,M 15 H,M 14 ADRA1B ADRA1A R46 , TR 5 , VRA29H,M 239 AVPR1A H,M 153 NTSR2 H,M 67 DRD4 H,M 52 CCXCR1 DB 1HM*rA 0 T2 9 , CKR 8 , GR433H,M 363 *GPR64 H, 281 H,M 280 *EBI2 *CMKLR1 H,M 194 H,M 193 HTR2B HTR2A M 108 M 107 *MrgA5 *MrgA4 H,M 22 H,M 21 ADRB3 ADRB2 FRR48 TE217HM*P5 5 H, 253 *GPR52 H,M 167 PTGER2 M 81 M *FPR-RS4 79 *FPR-RS2 AR 3HMPGR 6 , GR825HGG 3 , T7FL 1 H, 414 413 *TM7SF1L2 *TM7SF1L1 H,M H,M 340 339 GLP1R GCGR H,M 256 H 255 *GPR37 *GPR78 H,M 170 H,M 169 PTGFR PTGER4 H,M 84 H,M 83 GALR3 GALR2 P24 H,M 46 GPR2 P3 6HTX2 7 , GR128H,M 258 *GPR41 H, 254 H, *GPR26 252 *GPR21 H,M 247 H,M 172 *GPR85 H, TBXA2R 245 H,M H,M 242 H,M 241 *LGR6 168 H,M PTGER3 OXTR AVPR2 166 PTGER1 H, H,M 162 161 H HCRTR1 86 H, H,M 85 RHO 160 H,M 159 OPN1SW GPR38 H,M H,M H,M H,M OPN1MW GHSR 375 82 156 155 H, 374 H, M OPRM1 228 OPRK1 GALR1 80 H,M *GPR56 *FLJ14454 370 *TAR3 *FPR-RS3 H H,M 76 75 H,M *TEM5 H,M 366 74 H,M FPRL1 295 73 FPR1 H EDNRB 365 *KIAA0758 H,M H EDNRA 69 *GPR34 H,M 70 H,M 292 H, *DJ287G14 291 H, H,M 143 290 142 H, TG1019 289 NPFF1R FY *GPR31 NMU2R H,M *GPR30 287 H,M *GPR25 H, H, 286 *GPR22 139 285 H,M H,M 284 H, MTNR1B *GPR19 283 209 H,M *GPR18 H, 208 *GPR17 H,M 207 282 *GPR15 GPR68 *GPR1 GPR65 H,M H,M GPR4 H,M 57 *GPCR150 H,M 205 56 204 H,M 203 H,M CXCR4 202 SSTR5 SSTR4 GPR9 H,M H,M SSTR3 53 200 H,M H,M SSTR2 344 199 M CX3CR1 H,M 198 M 197 HTR7 H,M 123 M 196 HTR6 H,M 122 M PTHR2 HTR5B 195 HTR5A 121 *MrgB3 *MrgB2 M HTR4 HTR2C 120 *MrgB1 M M 119 M 118 H, *MrgA19 265 M 117 *MrgA16 *MrgA15 116 M *MrgA14 M 115 *MrgA13 *GPR103 114 M H,M M 261 113 *MrgA12 M H,M 112 *MrgA11 37 111 H,M M *MrgA10 36 H,M M 110 *MrgA9 35 *GPR63 *MrgA8 109 CCR1 H,M *MrgA7 34 CNR2 H,M H,M *MrgA6 33 CNR1 32 H,M BDKRB2 31 H,M H,M BDKRB1 30 178 NMBR H,M H,M 29 GRPR 28 F2RL2 H,M BRS3 27 H,M AGTRL1 H,M H,M 26 174 25 AGTR2 H,M AGTR1 24 H,M GPR73L1 GPR77 23 C5R1 C3AR1 ADMR H,M 92 HRH4 H 88 GNRHR2 H,M 6 H,M ADORA1 3 H,M 2 H,M #1 CHRM3 CHRM2 CHRM1 L15 , P7 4 , GR0 3 MG 1 , R636H, 396 GRM6 H,M 317 *MRGF H, 163 HCRTR2 231 H 230 *TA7 *GPR102 H 77 FPRL2 H,M 145 H,M 144 GPR7 GPR74 H,M H,M 59 58 CXCR6 BLR1 YL16 , P2 4 , T1 234 232 233 *TA11 *TA8 *TA10 H,M 148 H,M H 147 146 NPY2R NPY1R GPR8 H,M 62 H,M 61 H,M 60 CYSLT1 CCKBR CCKAR R26 , P6 5 T1 237 *TA15 M 151 NPY6R H,M 65 DRD2 R36 H,M 66 DRD3 DR2 , HG 4HMPR110HM*RA27HM*A230H, 350 *BAI2 H,M 267 *GRCA H,M 181 H,M 180 P2RY2 P2RY1 H,M 95 H,M 94 TSHR H,M LHCGR 90 HRH2 H,M 10 H,M 9 H,M 8 P2RY12 ADORA3 ADORA2B H,M 4 CHRM4 DAA1 , MG 0 , T1 8 , FS7 7 , LC 5 H, 359 *LEC3 H,M 276 *FKSG79 H,M 190 H,M 189 HTR1D HTR1B M 104 H,M 103 H *MrgA1 102 *MRGD MRGX4 H,M 18 H,M 17 H,M 16 ADRA2B ADRA2A ADRA1D C54 , Mg817MEG 1 , GR530HM*LR 8 H,M 383 *VLGR1 H,M 303 H, 302 H,M H,M 301 300 H,M *GPR75 299 H,M *GPR62 298 *GPR61 *GPR55 *GPR44 *GPR40 H,M 216 H,M 215 H,M H,M 214 213 EDG7 H,M 212 EDG6 H,M 211 EDG5 EDG4 EDG3 EDG2 M 130 M 129 M M *MrgB13 128 127 M *MrgB11 126 M *MrgB10 125 *MrgB8 *MrgB6 *MrgB5 H,M 45 H,M 44 H,M 43 H,M CCR9 42 H,M CCR8 41 H,M CCR7 40 H,M CCR6 39 CCR5 CCR4 CCR3 C23 , Mg414MEG 1 , GR927H, 297 *GPR39 H,M 210 EDG1 M 124 *MrgB4 H,M 38 CCR2 Gene
Database ID M M M Species Orexin/Hypocretin Opsin MAS-related gene Hormone protein Opioid/nociceptin Neuropeptide Y Neuropeptide W Neuropeptide FF Neurotensin Neuromedin U Melatonin Melanocortin hormone Melanin-concentratin Leukotriene KiSS-1 Histamine GNRH Prostanoid PAF
Family g P5 5 , T1 236 *TA14 H,M 150 NPY5R PD 5 , VRB20H,M 240 AVPR1B H,M 154 OPRD1 L 3 AR 1 , GR235H, H,M 305 306 H,M 304 *GPR82 *GPR84 227 *GPR80 H,M 152 TAR2 H, NTSR1 224 *GPR58 H,M H,M 218 219 H,M 217 TACR1 TACR2 H,M 141 EDG8 GPR66 H,M 138 MTNR1A H,M H 133 132 H,M 131 MC1R SLT GPR24 H,M 270 H, 269 *SALPR *HGPCR11 H,M 183 H,M 182 P2RY6 P2RY4 H,M 97 H,M 96 LTB4R GPR54 H,M 89 H,M HRH1 #87 GNRHR TD 6 , GR221HMCLR 3 H,M 335 CALCRL H, 257 *GPR37L1 H,M H,M 251 250 *GPR12 *GPR6 H,M 171 PTGIR H,M 165 H,M 164 PTGDR PTAFR Gene
Database ID M M M M Species endoGPCR Genes Orphan groupA2 Orphan groupA1 Vasopressin/Oxytocin Tachykinin Sphingolipid Purinoceptor Urotensin II Trace amine TRH SPC/LP Somatostatin Serotonin Retinal Relaxin/INSL3 Proteinase-activated Prolactin RF Prokineticin 2 Orphan groupA5 SREB LGR Orphan groupA4 Orphan groupA3 C Family GR329H,M 259 *GPR43 T1 8 , PY025HM*E238H, H, 358 288 *GPR20 *LEC2 H,M H,M H, 201 275 274 SSTR1 H,M #343 *P2Y10 *GPR23 PTHR1 H,M H,M H,M 188 262 187 H, H,M HTR1A 185 #260 RGR *GPR83 LGR7 *GPR45 H,M 176 H,M 175 F2R H,M GPR10 #173 GPR73 GR726HM*R 3 , Z848H,M 408 FZD8 H,M 333 *RRH H,M 246 *GPR27 H, 243 *GPR48 H,M 238 H, GPR14 310 H,M H,M 308 376 *GPR101 *GPR91 *OA1 H,M 223 H,M 221 *GPR57 H 293 TRHR *GPR32 H,M 206 G2A GR 4 H,M 249 H, 248 *GPR3 *SREB3 316 *MRGE H,M 312 *HGPCR2 H,M 229 *TAR4 H,M 225 *PNR Gene
Database ID *PGR6 *PGR5 M M M M *PGR4 M M M *PGR7 M M *PGR14 M M M M M M M M M M M Species Orphan groupA14 Orphan groupA13 Orphan groupA12 Orphan groupA11 Orphan groupA10 Orphan groupA9 Orphan groupA8 Orphan groupA7 Orphan groupA6 Glucagon Other Or GHRH GIP releasin Corticotro Calcitonin g p hormone p han Genes in- Family Class B *PGR3 *GPR103L *PGR15L *PGR11 *PGR15 GR022M*M335H 355 *EMR3 M 272 *GPR90 *PGR8 *PGR10 AR 7 H, 279 *AGR9 HH 4 , TR4 1 H, 416 *TPRA40 H,M 342 H, GHRHR 338 H,M 337 H,M 336 H,M GIPR 334 CRHR2 CRHR1 CALCR HMPI2 314 *HUMNPIIY20 L2 4 H, 341 GLP2R H, 332 H, 394 *RE2 GRM4 H,M 390 *RAI3 H 315 H,M *MRG 311 *H963 H,M 296 M 294 *GPR35 *GPR33 *PGR13 *PGR12 MG 318 *MRGG ON 2 , GR6 9 H,M H,M 399 398 *GPRC6A GRM8 H,M 320 H,M 319 *OPN4 *OPN3 *PGR1 *PGR2
Gene 323 322 278 266 264 327 263 325 330 326 329 328 321 324 268 277 Database ID H H,M H,M H H,M H,M H H,M H,M H H H H,M H,M H,M M M M H ,M ,M MGM 9 H,M 393 GRM3 ,M MGM 9 H, 395 GRM5 ,M MGM 9 H, 397 GRM7 ,M ,M M M M M *PGR17 M M M M M M M *PGR21 *PGR19 M M M M M *PGR25 M Species Other OrphanGenes Proto-cadherin Latrophilin like receptor(EMR) EGF-like DAF angiogenesis inhibitor Brain-s intestinal Vasoactive PACA Secretin Parathyroid hormone Other OrphanGenes Orphan groupB3 Orphan groupB2 Orphan groupB1 Other OrphanGenes Orphan groupN1 Smoothened Frizzled glutamate Metabotro GPRC5 GABA- Calcium-sensin P B p ecifi , mucin p p e ic p c tide Family g - Class F/S No class Class C CLR 6 H,M 361 *CELSR2 Z242H,M 402 FZD2 Z545H,M 405 FZD5 Z444H,M 404 H,M 403 FZD4 FZD3 *PGR28 CLR 6 H,M 360 *CELSR1 H,M H,M 353 352 H, 351 H, *EMR1 349 H,M CD97 348 H,M *BAI3 347 H, *BAI1 345 H,M VIPR2 346 VIPR1 ADCYAP1R1 SCTR GR5 8 H,M 388 *GPRC5C MH41H,M 411 SMOH H,M 401 FZD1 H,M 391 GRM1 H,M 387 H,M H,M 385 384 *GPRC5B GABBR1 CASR *PGR16 KA12 371 *KIAA1828 H, 357 *LEC1 GR5 8 H,M 389 *GPRC5D CLR 6 H,M 362 *CELSR3 T7F 1 H,M 412 *TM7SF1 T7F 1 H,M 415 *TM7SF3 H,M 407 FZD7 H,M 373 *ETL *PGR24 *PGR22 Z949H,M 409 FZD9 *PGR23 *PGR20 *PGR18 Z1 1 H 410 FZD10 *PGR27 *PGR26
Gene 400 356 364 372 368 379 378 377 369 367 382 381 380 Database ID H H H,M H,M H,M H H H,M H,M H,M H H,M H,M H,M H,M H ,M ,M ,M ,M ,M ,M M M M M M M M M M M M M M M M M Species