Author Manuscript Published OnlineFirst on October 5, 2010; DOI: 10.1158/1535-7163.MCT-10-0376 AuthorPublished manuscripts OnlineFirst have been peeron Octoberreviewed and 5, 2010accepted as for10.1158/1535-7163.MCT-10-0376 publication but have not yet been edited. Identification of Predictive Markers of Response to the MEK1/2 Inhibitor Selumetinib (AZD6244) in KRAS-Mutated Colorectal Cancer John J. Tentler1, Sujatha Nallapareddy1, Aik Choon Tan1, Anna Spreafico1, Todd M. Pitts1, M. Pia Morelli1, Heather M. Selby1, Maria I. Kachaeva1, Sara A. Flanigan1, Gillian N. Kulikowski1, Stephen Leong1 John J. Arcaroli1, Wells A. Messersmith1 and S. Gail Eckhardt1 Author Affilliations: Division of Medical Oncology1, University of Colorado Denver Anschutz Medical Campus, Aurora, Colorado Running Title: Predictive Biomarkers for Selumetinib in CRC Key Words: MEK inhibitors, predictive biomarkers, colorectal cancer Abbreviations: CRC: colorectal cancer; MAPK: mitogen activated protein kinase; MEK: MAPK/ERK kinase; EGFR: epidermal growth factor receptor; FZD2: frizzled homolog 2 Financial Support: Research grants CA106349 (SGE); CA079446 (SGE), CA46934 (NCI Cancer Center Support Grant); AstraZeneca Inc. Research Agreement (AS, SGE); Cancer League of Colorado Seed Grant (JJT). Requests for reprints: John J. Tentler, Ph.D. 12801 E 17th Ave, MS 8117, Aurora, CO 80045. email:
[email protected]; 1 1 Potential Conflicts of Interest: Research funding provided by AstraZeneca to AS, SGE. Author manuscripts have been peer reviewed and accepted for publication but have not yet been edited. Copyright © 2010 American Association for Cancer Research 1 Downloaded from mct.aacrjournals.org on September 30, 2021. © 2010 American Association for Cancer Research. Author Manuscript Published OnlineFirst on October 5, 2010; DOI: 10.1158/1535-7163.MCT-10-0376 Author manuscripts have been peer reviewed and accepted for publication but have not yet been edited.