(12) United States Patent (10) Patent No.: US 9,283,215 B2 Zeldis (45) Date of Patent: *Mar
US009283215 B2 (12) United States Patent (10) Patent No.: US 9,283,215 B2 Zeldis (45) Date of Patent: *Mar. 15, 2016 (54) METHODS FORTREATING MULTIPLE (2013.01); A61 K3I/4439 (2013.01); A61 K MYELOMAUSING 4-(AMINO)-2- 31/475 (2013.01); A61 K3I/515 (2013.01); (2,6-DIOXO(3-PIPERIDYL))-ISOINDOLINE- A6 IK3I/573 (2013.01); A61 K3I/675 SES COMBINATION WITH (2013.01); A61 K3I/704 (2013.01); A61 K 31/7048 (2013.01); A61 K35/12 (2013.01); (71) Applicant: Celgene Corporation, Summit, NJ (US) A61K39/00II (2013.01); A61 K39/3955 (2013.01); A61K 45/06 (2013.01); A61 K (72) Inventor: Jerome B. Zeldis, Princeton, NJ (US) 2300/00 (2013.01) (58) Field of Classification Search (73) Assignee: Celgene Corporation, Summit, NJ (US) CPC ........... A61K 31/4462: A61K 31/4035; A61 K (*) Notice: Subject to any disclaimer, the term of this 31f445 patent is extended or adjusted under 35 USPC .......................................... 514/323,329–330 U.S.C. 154(b) by 0 days. See application file for complete search history. This patent is Subject to a terminal dis claimer. (56) References Cited (21) Appl. No.: 14/201,069 U.S. PATENT DOCUMENTS (22) Filed: Mar. 7, 2014 3.536.809 A 10, 1970 Applezweig 3,598,123 A 8, 1971 Zaffaroni et al. O O 3,845,770 A 11/1974 Theeuwes et al. (65) Prior Publication Data 3,916,899 A 1 1/1975 Theeuwes et al. US 2014/0186404 A1 Jul. 3, 2014 4,008,719 A 2f1977 Theeuwes et al. 4,810,643 A 3, 1989 Souza Related U.S.
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