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(12) United States Patent (10) Patent No.: US 9,283,215 B2 Zeldis (45) Date of Patent: *Mar

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(12) United States Patent (10) Patent No.: US 9,283,215 B2 Zeldis (45) Date of Patent: *Mar US009283215 B2 (12) United States Patent (10) Patent No.: US 9,283,215 B2 Zeldis (45) Date of Patent: *Mar. 15, 2016 (54) METHODS FORTREATING MULTIPLE (2013.01); A61 K3I/4439 (2013.01); A61 K MYELOMAUSING 4-(AMINO)-2- 31/475 (2013.01); A61 K3I/515 (2013.01); (2,6-DIOXO(3-PIPERIDYL))-ISOINDOLINE- A6 IK3I/573 (2013.01); A61 K3I/675 SES COMBINATION WITH (2013.01); A61 K3I/704 (2013.01); A61 K 31/7048 (2013.01); A61 K35/12 (2013.01); (71) Applicant: Celgene Corporation, Summit, NJ (US) A61K39/00II (2013.01); A61 K39/3955 (2013.01); A61K 45/06 (2013.01); A61 K (72) Inventor: Jerome B. Zeldis, Princeton, NJ (US) 2300/00 (2013.01) (58) Field of Classification Search (73) Assignee: Celgene Corporation, Summit, NJ (US) CPC ........... A61K 31/4462: A61K 31/4035; A61 K (*) Notice: Subject to any disclaimer, the term of this 31f445 patent is extended or adjusted under 35 USPC .......................................... 514/323,329–330 U.S.C. 154(b) by 0 days. See application file for complete search history. This patent is Subject to a terminal dis claimer. (56) References Cited (21) Appl. No.: 14/201,069 U.S. PATENT DOCUMENTS (22) Filed: Mar. 7, 2014 3.536.809 A 10, 1970 Applezweig 3,598,123 A 8, 1971 Zaffaroni et al. O O 3,845,770 A 11/1974 Theeuwes et al. (65) Prior Publication Data 3,916,899 A 1 1/1975 Theeuwes et al. US 2014/0186404 A1 Jul. 3, 2014 4,008,719 A 2f1977 Theeuwes et al. 4,810,643 A 3, 1989 Souza Related U.S. Application Data 4,999.291 A 3, 1991 Souza 5,059,595 A 10/1991 Le Grazie (63) Continuation of application No. 13/782,728, filed on 5,073,543 A 12/1991 Marshall et al. Mar. 1, 2013, now Pat. No. 8,673.939, which is a continuations ofs application No. s 13/488,888,s s filed on (Continued)Cont d Jun. 5, 2012, now Pat. No. 8,648,095, which is a FOREIGN PATENT DOCUMENTS continuation of application No. 12/640,702, filed on Dec. 17, 2009, now Pat. No. 8,198.306, which is a WO WO92, 14455 9, 1992 continuation of application No. 10/438,213, filed on WO WO94/20085 9, 1994 May 15, 2003, now Pat. No. 7,968,569. (Continued) (60) Provisional application No. 60/380,842, filed on May 17, 2002, provisional application No. 60/424,600, OTHER PUBLICATIONS filed on Nov. 6, 2002. U.S. Appl. No. 60/499,723, Markian. (51) Int. Cl. (Continued) A6 IK3I/445 (2006.01) A6 IK3I/4462 (2006.01) A6 IK3I/4035 (2006.01) Primary Examiner — Jeffrey S Lundgren 3. f 3.08: Assistant Examiner — Chris Simmons A6 IK3I/40 (2006.01) (74) Attorney, Agent, or Firm — Jones Day A6 IK3I/425 (2006.01) A6 IK3I/55 (2006.01) (57) ABSTRACT A6 IK 45/06 (2006.01) A6 IK3I/4439 (2006.01) Methods of treating, preventing and/or managing cancer as A 6LX3/573 (2006.01) well as and diseases and disorders associated with, or char A6 IK3I/98 (2006.01) acterized by, undesired angiogenesis are disclosed. Specific A6 IK3I/475 (2006.01) methods encompass the administration of an immunomodu A6 IK3I/675 (2006.01) latory compound alone or in combination with a second A6 IK3I/704 (2006.01) active ingredient. The invention further relates to methods of A6 IK3I/7048 (2006.01) reducing or avoiding adverse side effects associated with A6 IK35/12 (2015.01) chemotherapy, radiation therapy, hormonal therapy, biologi A 6LX39/395 (2006.01) cal therapy or immunotherapy which comprise the adminis A6 IK39/00 (2006.01) tration of an immunomodulatory compound. Pharmaceutical (52) U.S. Cl. compositions, single unit dosage forms, and kits suitable for CPC ............... A6 IK3I/454 (2013.01); A61 K3I/00 use in methods of the invention are also disclosed. (2013.01); A61 K3I/198 (2013.01); A61 K 31/40 (2013.01); A61 K31/4035 (2013.01); A6 IK3I/425 (2013.01); A61 K3I/445 28 Claims, 1 Drawing Sheet US 9,283,215 B2 Page 2 (56) References Cited 2004.0029832 A1 2/2004 Zeld is 2004/OO77685 A1 4/2004 Figg et al. U.S. PATENT DOCUMENTS 2004f0077686 A1 4/2004 Dannenberg et al. 2004/OO87546 A1 5, 2004 Zeld is 5, 120,548 6, 1992 McClelland et al. 2004/0091455 A1 5, 2004 Zeld is 5,134,127 7, 1992 Stella et al. 2004/O122052 A1 6/2004 Muller et al. 5,229,496 7, 1993 Deeley et al. 2004/0266809 A1 12/2004 Emanuel et al. 5,354,556 10, 1994 Sparks et al. 2008. O145368 A1 6/2008 Zeld is 5,385,901 1, 1995 Kaplanet al. 2008/0292583 A1 11/2008 Zelds 5,391485 2, 1995 Deeley et al. 2009/0010877 A1 1/2009 Zeld is 5,393,870 2, 1995 Deeley et al. 2009/0123416 A1 5, 2009 Zelds 5,528,823 6, 1996 Rudy, Jr. et al. 2010/0093.683 A1 4/2010 Zeld is 5,580,755 12, 1996 Souza 2010, 0196369 A1 8, 2010 Zeld is 5,591,767 1/1997 Mohr et al. 2010.0260719 A1 10, 2010 Zelds 5,593.990 1/1997 D'Amato 2012, 0035145 A1 2/2012 Zeld is 5,629,327 5, 1997 D'Amato 2012/0135042 A1 5, 2012 Zeld is 5,635,517 6, 1997 Muller et al. 2013,0183381 A1 7/2013 Zeld is 5,639,476 6, 1997 Oshlack et al. 2015,0190386 A1 7, 2015 Zelds 5,674,533 10, 1997 Santus et al. 5,698,579 12, 1997 Muller FOREIGN PATENT DOCUMENTS 5,712,291 1, 1998 D'Amato 5,731,325 3, 1998 Andrulis, Jr. et al. WO WO98,035O2 1, 1998 5,733,566 3, 1998 Lewis WO WO 98.5417O 12/1998 5,798,368 8, 1998 Muller et al. WO WOO 1/70275 9, 2001 5,874.448 2, 1999 Muller et al. WO WOO1? 87307 11, 2001 5,877,200 3, 1999 Muller WO WO O2, 15926 2, 2002 5,929, 117 7, 1999 Muller et al. WO WO O2/O59 106 8, 2002 5,955,476 9, 1999 Muller et al. WO WO O2/O64083 8, 2002 6,020,358 2, 2000 Muller et al. WO PCT/USO3/11578 4/2003 6,071,948 6, 2000 D'Amato WO WOO3,O86373 10, 2003 6,114,355 9, 2000 D'Amato 6,140,346 10, 2000 Andrulis, Jr. et al. OTHER PUBLICATIONS 6,228,879 5, 2001 Green et al. 6,235,756 5, 2001 D'Amato U.S. Appl. No. 60/372,348, Hariri et al. 6,281.230 8, 2001 Muller et al. U.S. Appl. No. 10/732,867, D'Amato et al. 6,316,471 11, 2001 Muller et al. U.S. Appl. No. 09/545,654, D'Amato. 6,326,388 12, 2001 Man et al. U.S. Appl. No. 09/287,377, D'Amato. 6,335,349 1, 2002 Muller et al. Carstensen, 1995, Drug Stability. Principles & Practice. 2". ed., 6,380,239 4, 2002 Muller et al. Marcel Dekker, New York, NY pp. 379-380. 6,395,754 5, 2002 Muller et al. Corral et al., 1999. “Immunomodulation by thalidomide and 6,403,613 6, 2002 Man et al. thalidomide analogues.” Ann. Rheum. Dis. 58(Suppl 1):I107-113. 6,420,414 T/2002 D'Amato Craig et al., 1967. "Potential anticancer agents. III. 6,458,810 10, 2002 Muller et al. 2-phthalimidoaldehydes and derivatives.” Potential Anticancer 6,469,045 10, 2002 D'Amato 6,476,052 11, 2002 Muller et al. Agents III 10:1071-1073. 6,518.298 2, 2003 Green et al. D'Amato et al., 2001, “Mechanism of action of thalidomide and 6,555,554 4, 2003 Muller et al. 3-aminothalidomide in multiple myeloma.” Semin Oncol. 28:597 6,673,828 1, 2004 Green et al. 601. 7,323.479 1, 2008 Zeld is D'Amato et al., 1994, “Thalidomide is an Inhibitor of Angiogenesis'. 7,393,862 T/2008 Zeld is Proc. Natl. Acad. Sci. 91:4082-4085. 7,435,745 10, 2008 D'Amato De et al., 1976, "Hansch analysis for some antineoplastic 7.468,363 12, 2008 Zeld is glutarimides,” J. Indian Chem. Soc. I.III: 825-826. 7,968,569 6, 2011 Zeld is De et al., 1976, "Possible antineoplastic agents: III. Synthesis of 8,188,118 5, 2012 Zeld is 6-alkyl-2-4'-methoxyphthalimido and 6-alkyl-3-3'-4'- 8, 198,262 6, 2012 Zeld is dimethoxyphenylglutarimides,” J. Indian Chem. Soc. I.III: 1122 8,722,647 5, 2014 Zeld is 1125. 8,759,375 6, 2014 Zeld is 2001 OO18445 8, 2001 Huang et al. Dredge et al., 2002, “Novel thalidomide analogues display anti 2001.0056114 12, 2001 D'Amato angiogenic activity independently of immunomodulatory effects.” 2002fOO35090 3, 2002 Zeldis et al. Br. J. Cancer 87(10): 1166-1172. 2002/0045643 4, 2002 Muller et al. Folkman et al., 1983, "Angiogenesis inhibition and tumor regression 2002fOO52398 5, 2002 D'Amato caused by heparin or a heparin fragment in the presence of cortisone.” 2002.0054899 5, 2002 Zeld is Science 221(4612):719-725. 2002fOO61923 5, 2002 D'Amato Gershbein, 1991, “The thalidomide analog, EM 12, enhances 1.2- 2002/O128228 9, 2002 Hwu dimethylhydrazine-induction of rat colon adenocarcinomas. Cancer 2002fO161023 10, 2002 D'Amato Letters 60: 129-133. 2002/0173658 11, 2002 Muller et al. 2002/0183360 12, 2002 Muller et al. Grabstald et al., 1965, "Clinical experiences with thalidomide in 2003/0013739 1, 2003 Masferrer patients with cancer.” Clinical Pharmacology and Therapeutics 2003/0028028 2, 2003 Man et al.
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