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Tanibirumab (CUI C3490677) Add to Cart 5/17/2018 NCI Metathesaurus Contains Exact Match Begins With Name Code Property Relationship Source ALL Advanced Search NCIm Version: 201706 Version 2.8 (using LexEVS 6.5) Home | NCIt Hierarchy | Sources | Help Suggest changes to this concept Tanibirumab (CUI C3490677) Add to Cart Table of Contents Terms & Properties Synonym Details Relationships By Source Terms & Properties Concept Unique Identifier (CUI): C3490677 NCI Thesaurus Code: C102877 (see NCI Thesaurus info) Semantic Type: Immunologic Factor Semantic Type: Amino Acid, Peptide, or Protein Semantic Type: Pharmacologic Substance NCIt Definition: A fully human monoclonal antibody targeting the vascular endothelial growth factor receptor 2 (VEGFR2), with potential antiangiogenic activity. Upon administration, tanibirumab specifically binds to VEGFR2, thereby preventing the binding of its ligand VEGF. This may result in the inhibition of tumor angiogenesis and a decrease in tumor nutrient supply. VEGFR2 is a pro-angiogenic growth factor receptor tyrosine kinase expressed by endothelial cells, while VEGF is overexpressed in many tumors and is correlated to tumor progression. PDQ Definition: A fully human monoclonal antibody targeting the vascular endothelial growth factor receptor 2 (VEGFR2), with potential antiangiogenic activity. Upon administration, tanibirumab specifically binds to VEGFR2, thereby preventing the binding of its ligand VEGF. This may result in the inhibition of tumor angiogenesis and a decrease in tumor nutrient supply. VEGFR2 is a pro-angiogenic growth factor receptor tyrosine kinase expressed by endothelial cells, while VEGF is overexpressed in many tumors and is correlated to tumor progression. Check for active clinical trials using this agent. (NCI Thesaurus) Synonyms & Abbreviations: (see Synonym Details) tanibirumab TTAC-0001 External Source Codes: NCI Thesaurus Code C102877 (see NCI Thesaurus info) PDQ Closed Trial Search ID 738495 PDQ Open Trial Search ID 738495 (check for NCI PDQ open clinical trial info) Other Properties: Name Value Source DATE_FIRST_PUBLISHED 2012-08-13 PDQ DATE_LAST_MODIFIED 2012-08-29 PDQ FR 3 MSH HM D000911 MSH MDA 20120310 MSH NCI_THESAURUS_CODE C102877 PDQ ORIG_STY Drug/agent PDQ RN 0 MSH SC 1 MSH SOS targets VEGFR2 MSH SRC Arch Pharm Res. 2011 Aug;34(8):1223-6. MSH TERMUI T819268 MSH TERMUI T819269 MSH TH NLM (2012) MSH Additional Concept Data: (none) URL to Bookmark: https://ncim.nci.nih.gov/ncimbrowser/ConceptReport.jsp?dictionary=NCI Metathesaurus&code=C3490677 Synonym Details: Term Source Type Code tanibirumab MSH NM C570591 Tanibirumab NCI PT C102877 tanibirumab PDQ PT CDR0000738495 TTAC-0001 MSH PCE C570591 TTAC-0001 NCI CCN C102877 TTAC-0001 PDQ CON CDR0000738495 https://ncim.nci.nih.gov/ncimbrowser/pages/concept_details.jsf?dictionary=NCI%20Metathesaurus&code=C3490677&type=all 1/79 5/17/2018 NCI Metathesaurus Relationships with other NCI Metathesaurus Concepts: Parents | Children | Broader | Narrower | Siblings | Other Parent Concepts: Relationship Rel. Attribute Name Rel. Source Parent isa Monoclonal Antibodies NCI Parent Pharmaceutical Preparations PDQ Child Concepts: (none) Broader Concepts: Relationship Rel. Attribute Name Rel. Source Broader mapped_to Monoclonal Antibodies MSH Narrower Concepts: (none) Sibling Concepts: Relationship Rel. Attribute Name Rel. Source Sibling Abortifacient Agents CSP Sibling antagonists & inhibitors CSP Sibling Anti-Allergic Agents CSP Sibling Anti-Infective Agents CSP Sibling Anti-Inflammatory Agents CSP Sibling antiarthritic agent CSP Sibling antidiuretic CSP Sibling Antidote CSP Sibling Antimetabolites CSP Sibling Antineoplastic Agents CSP Sibling Antirheumatic Agents CSP Sibling Antispasmodic Agent CSP Sibling Biological Factors CSP Sibling Carcinogen CSP Sibling Cardiovascular Agents CSP Sibling Chelating Agents CSP Sibling Chemical Surfactants CSP Sibling Choleretic agent CSP Sibling Cryoprotective Agent CSP Sibling dental agent CSP Sibling Diuretic CSP Sibling expectorant/mucolytic CSP Sibling eye agent CSP Sibling Fertility Agents CSP Sibling Gastrointestinal Agents CSP Sibling Gout Suppressants CSP Sibling Hematologic Agents CSP Sibling hyperglycemic agent CSP Sibling Hypoglycemic Agents CSP Sibling Immunomodulators CSP Sibling Mitogens CSP Sibling Multidrug Resistance Modulator CSP Sibling Muscle relaxants CSP Sibling Mutagen CSP Sibling Neuromuscular Blocking Agents CSP Sibling neuropharmacologic agent CSP Sibling nonenzyme proteolytic agent CSP Sibling Oxytocics CSP Sibling Pesticide CSP Sibling Photosensitizing Agent CSP Sibling Progestins CSP Sibling psychopharmacologic agent CSP Sibling Pyrogen CSP Sibling Radioprotective Agent CSP Sibling Radiosensitizing Agent CSP Sibling stimulant/agonist CSP Sibling Teratogen CSP Sibling Tocolytic Agents CSP Sibling Vitamins CSP Sibling weight control agent CSP Sibling XomaZyme CSP Sibling Antibodies, Monoclonal, Murine-Derived MSH Sibling controlled substance MSH Sibling Cosmeceuticals MSH Sibling Counterfeit Drugs MSH Sibling Designer Drugs MSH Sibling Dosage Forms MSH Sibling Drugs, Chinese Herbal MSH Sibling Drugs, Essential MSH Sibling Drugs, Non-Prescription MSH https://ncim.nci.nih.gov/ncimbrowser/pages/concept_details.jsf?dictionary=NCI%20Metathesaurus&code=C3490677&type=all 2/79 5/17/2018 NCI Metathesaurus Sibling Drug Combinations MSH Sibling Generic Drugs MSH Sibling Humanized Monoclonal Antibody MSH Sibling infliximab MSH Sibling Investigational New Drugs MSH Sibling Materia Medica MSH Sibling Medical Marijuana MSH Sibling Nostrums MSH Sibling Pharmaceutical Preparations, Dental MSH Sibling Pharmaceutic Aids MSH Sibling Placebos MSH Sibling Plant Extracts MSH Sibling Prescription Drugs MSH Sibling Prodrugs MSH Sibling Single-Chain Variable Fragment MSH Sibling Solutions MSH Sibling Street Drugs MSH Sibling Veterinary Drugs MSH Sibling Xenobiotics MSH Sibling 3H1 Aluminum Hydroxide-Precipitated Anti-Idiotype Monoclonal Antibody NCI Sibling A33 monoclonal antibody NCI Sibling Abciximab NCI Sibling adalimumab NCI Sibling Adecatumumab NCI Sibling Agonistic Anti-CD40 Monoclonal Antibody ADC-1013 NCI Sibling Alpha-Beta T-Cell Receptor Antibody NCI Sibling Amatuximab NCI Sibling Anrukinzumab NCI Sibling Anti-A33 Monoclonal Antibody KRN330 NCI Sibling Anti-A5B1 Integrin Monoclonal Antibody PF-04605412 NCI Sibling Anti-AGS-16 Monoclonal Antibody AGS-16M18 NCI Sibling Anti-AGS-8 Monoclonal Antibody AGS-8M4 NCI Sibling Anti-ALK-1 Monoclonal Antibody PF-03446962 NCI Sibling Anti-alpha5beta1 Integrin Antibody MINT1526A NCI Sibling Anti-alphaVbeta3 Monoclonal Antibody EMD 525797 NCI Sibling Anti-amyloid Monoclonal Antibody NEOD001 NCI Sibling Anti-ANG2 Monoclonal Antibody MEDI-3617 NCI Sibling Anti-angiopoietin Monoclonal Antibody AMG 780 NCI Sibling Anti-AXL Monoclonal Antibody-MMAE Conjugate NCI Sibling Anti-B7-H3 Antibody DS-5573a NCI Sibling Anti-c-fms Monoclonal Antibody AMG 820 NCI Sibling Anti-c-KIT Monoclonal Antibody KTN0158 NCI Sibling Anti-c-Met Monoclonal Antibody ABT-700 NCI Sibling Anti-c-Met Monoclonal Antibody ARGX-111 NCI Sibling Anti-c-MET Monoclonal Antibody LY2875358 NCI Sibling Anti-C-met Monoclonal Antibody SAIT301 NCI Sibling Anti-CA19-9 Monoclonal Antibody 5B1 NCI Sibling Anti-CD122 Humanized Monoclonal Antibody Mik-Beta-1 NCI Sibling Anti-CD123 Monoclonal Antibody CSL360 NCI Sibling Anti-CD123 Monoclonal Antibody KHK2823 NCI Sibling Anti-CD157 Monoclonal Antibody MEN1112 NCI Sibling Anti-CD19 Antibody-drug Conjugate SGN-CD19B NCI Sibling Anti-CD19 Monoclonal Antibody NCI Sibling Anti-CD20 Monoclonal Antibody PRO131921 NCI Sibling Anti-CD20 Monoclonal Antibody SCT400 NCI Sibling Anti-CD20 Monoclonal Antibody TL011 NCI Sibling Anti-CD22 Monoclonal Antibody-MMAE Conjugate DCDT2980S NCI Sibling Anti-CD25-PBD Antibody-drug Conjugate ADCT-301 NCI Sibling Anti-CD25 Monoclonal Antibody NCI Sibling Anti-CD2 Monoclonal Antibody NCI Sibling Anti-CD30/CD16A Monoclonal Antibody AFM13 NCI Sibling Anti-CD30 Monoclonal Antibody MDX-1401 NCI Sibling Anti-CD30 Monoclonal Antibody XmAb2513 NCI Sibling Anti-CD33/CD3 BiTE Antibody AMG 330 NCI Sibling Anti-CD33 Monoclonal Antibody BI 836858 NCI Sibling Anti-CD37 Monoclonal Antibody BI 836826 NCI Sibling Anti-CD38 Monoclonal Antibody MOR03087 NCI Sibling Anti-CD3 Monoclonal Antibody NCI Sibling Anti-CD40 Monoclonal Antibody NCI Sibling Anti-CD44 Monoclonal Antibody RO5429083 NCI Sibling Anti-CD45 Monoclonal Antibody NCI Sibling Anti-CD45 Monoclonal Antibody AHN-12 NCI Sibling Anti-CD45 Monoclonal Antibody BC8 NCI Sibling Anti-CD47 Monoclonal Antibody CC-90002 NCI Sibling Anti-CD47 Monoclonal Antibody Hu5F9-G4 NCI Sibling Anti-CD4 Monoclonal Antibody NCI Sibling Anti-CD52 Monoclonal Antibody NCI Sibling Anti-CD5 Monoclonal Antibody NCI https://ncim.nci.nih.gov/ncimbrowser/pages/concept_details.jsf?dictionary=NCI%20Metathesaurus&code=C3490677&type=all 3/79 5/17/2018 NCI Metathesaurus Sibling Anti-CD6 Monoclonal Antibody NCI Sibling Anti-CD70 Antibody-drug Conjugate SGN-CD70A NCI Sibling Anti-CD70 Monoclonal Antibody ARGX-110 NCI Sibling Anti-CD70 Monoclonal Antibody MDX-1411 NCI Sibling Anti-CD73 Monoclonal Antibody BMS-986179 NCI Sibling Anti-CD73 Monoclonal Antibody MEDI9447 NCI Sibling Anti-CD7 Monoclonal Antibody NCI Sibling Anti-CD8 Monoclonal Antibody NCI Sibling Anti-CD98 Monoclonal Antibody IGN523 NCI Sibling Anti-CEA/Anti-HSG Bispecific Monoclonal Antibody TF2 NCI Sibling Anti-CEACAM1 Monoclonal Antibody CM-24 NCI Sibling Anti-CEA Antibody NCI Sibling Anti-CEA BiTE Monoclonal Antibody MEDI-565 NCI Sibling Anti-CLDN6 Monoclonal Antibody IMAB027 NCI Sibling Anti-CSF1R
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