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Annual Report 2005 ANNUAL REPORT 2005 COLD SPRING HA ,§1L._ABORATORY ti COLD SPRINGHARBOR LABORAT( ANNUAL REPORT 2005 © 2006 by Cold Spring Harbor Laboratory Cold Spring Harbor Laboratory One Bungtown Road Cold Spring Harbor, New York 11724 www.cshl.edu Managing Editors Lisa M. Becker, Jeff Picarello Production Editor Rena Steuer Copy Editor Dorothy Brown Development Manager Jan Argentine Project Coordinators Mary Cozza, Maria Fairchild Production Manager Denise Weiss Desktop Editor Susan Schaefer Nonscientific Photography Miriam Chua, Bill Geddes Cover Designer Denise Weiss Book Designer Emily Harste Front cover: Looking across Cold Spring Harbor at Knight House (left) and the newly dedicated Cutting House (right). Both serve as graduate housing for students in the Watson School. (Photo by Miriam Chua.) Back cover: Additional graduate housing located on Uplands Farm dedicated in 2006 in honor of Elisabeth Livingston, William Miller, and Wendy Vander Poel Russell. (Photo by Miriam Chua.) Section title pages: Miriam Chua Press title page: Rena Steuer Contents Officers of the Corporation and Board of Trusteesiv-v Governance vi Committees of the Board vii H. Bentley Glass (1906-2005) viii Ernst Mayr (1904-2005) x PRESIDENT'S REPORT Highlights of the Year 3 CHIEF OPERATING OFFICER'S REPORT 19 RESEARCH 23 Cancer: Gene Expression 25 Cancer: Genetics 46 Cancer: Cell Biology 81 Neuroscience 105 Plant Genetics 150 Bioinformatics and Genomics 169 CSHL Fellows 183 Author Index 187 WATSON SCHOOL OF BIOLOGICAL SCIENCES 189 Dean's Report 191 Courses203 Undergraduate Research Program 211 Partners for the Future 213 Nature Study Program 214 COLD SPRING HARBOR LABORATORY MEETINGS AND COURSES 217 Academic Affairs 218 Symposium on Quantitative Biology 220 Meetings 223 Postgraduate Courses 271 Seminars 329 BANBURY CENTER 331 Executive Director's Report 333 Meetings 338 DOLAN DNA LEARNING CENTER 383 Executive Director's Report 385 2005 Workshops, Meetings, and Collaborations396 COLD SPRING HARBOR LABORATORY PRESS 401 2005 Publications 402 Executive Director's Report 403 FINANCE 407 Financial Statements 408 Financial Support of the Laboratory411 Grants 411 Development 421 Capital and Endowment Contributions422 Annual Contributions425 LABORATORY STAFF 438 iii Officers of the Corporation Eduardo G. Mestre, Chairman Bruce Stillman, Ph.D., President Lola N. Grace, Vice Chairman James D. Watson, Ph.D., Chancellor Edward Travaglianti, Secretary/Treasurer W. Dillaway Ayres, Jr., Chief Operating Officer Board of Trustees Individual Trustees Trudy H. Calabrese Kristina Perkin Davison Joseph T. Donohue Jacob Goldfield Lola N. Grace Laurie J. Landeau, Lloyd Harbor, New York Partner, iEurope Capital Ll-C Managuug Recta, Cleacher .1. Goldfield 8 Co. Managing .ector, Ste., Grace V.M.D. Partners, LLC Capital Management &towel, Inc Stephen M. Lessing Robert D. Lindsay Nancy Marks Eduardo G. Mestre Douglas P. Morris Thomas C. Quick Managing Director, Co-Managing Partner, Cart Marks 8 Co., Inc Vice Chairman, Evercore Chairman and CEO, Pa. Beach, Florida Lehman Brothers Goldberg Lindsay 8 Co. Partners Universal Music Group William S. Robertson David M. Rubenstein Alm Seligson Andrew Solomon Arthur M. Spiro Alan C. Stephenson Naples, Florida Managing Dire,. NAK Internat.. New York, New York Kings Point, New York Penner Cravath Swalne The Carlyle Group Moore, LLP James M. Stone, Ph.D. Jerome Swartz, Ph.D. Edward Travaglianti James D. Watson, Ph.D.Roy J. Zuckerberg Chairman, The Plymouth Old Field, New York President, Commerce Bank Chancellor, New York, New York Rock Company Long Island Cold Spring Harbor Laboratory iv Scientific Trustees Laurence F. Abbott, Ph.D. David Botstein, Ph.D. Titia de Lange, Ph.D. Jeff Hawkins Susan Lee Lindquist, Ph.D. Columbia thWersity College of Director, Lewis-Siger Institute, Leon Hess Professor, The Founder and &earl. (Veda; Director, Whitehead Institute for Physicians and Surgeons Pnrceton (Joversqy Rockefeller University Re.cod Neuroscience Inst. Biomedical Research Bruce Stillman, Ph.D. Robert Tjian, Ph.D. Robert E. Wittes, M.D. President, HHAN Research Laboratory, Physician in Chief, Memorial Cold Spring Harbor Laboratory University of California, Berkeley Sloan- Kettering Cancer Center Honorary Trustees Bayard Clarkson, M.D. John P. Cleary, Esq. Charles F. Dolan Helen Ann Dolan Martha Farish Gerry Memorial Sloan-Kettering Locust Valley. New Y. Oyster Bay, New York Oyster Bay, New York Mill Neck, New Yak Cancer Center, New York Townsend J. Knight, Esq. Evelyn H. Lauder Mary D. Lindsay David L Luke Ill New Yolk, New York Es. Lauder Companies, New York, New York New York, New York William R. Miller William E. Murray, Esq. Wendy Vander Peel Russell Henry Wendt, Ill New York, New York New York, New York Oyster By New York Healdsburg, California V Governance The Laboratory is governed by a Board of Trustees of up to 35 members which meets three or four times a year. Authority to act for the Board of Trustees between meetings is vested in the Executive Committee of the Board of Trustees. The Executive Committee is composed of the Officers of the Board and any other members who may be elected to the Executive Committee by the Board of Trustees. Additional standing and ad hoc committees are appointed by the Board of Trustees to provide guidance and advice in specific areas of the Laboratory's operations. Representation on the Board of Trustees itself is divided between business and community leaders and scientists from major educational and research institutions. The Laboratory is chartered as an educational and research institution by the Board of Regents of the Education Department of the State of New York.It is authorized to operate a graduate program under the name "Cold Spring Harbor Laboratory, Watson School of Biological Sciences" and thereat to confer the degrees of Doctor of Philosophy (Ph.D.), Master of Science (M.S.), and Doctor of Science (Sc.D.), Honorary. It is designated as a "public charity" under Section 501(c)(3) of the Internal Revenue Code. vi Committees of the Board Ad Hoc Commercial Relations Jacob Goldfield Capital Campaign Lola N. Grace James M. Stone, Ph.D., Chair W. Dillaway Ayres, Jr. William S. Robertson W. Dillaway Ayres, Jr. Joseph T. Donohue David Botstein, Ph.D. Nominating Stephen M. Lessing Titia de Lange, Ph.D. Mary D. Lindsay Robert D. Lindsay, Chair John P. Maroney, Esq. Eduardo G. Mestre W. Dillaway Ayres, Jr. Rob Martienssen, Ph.D. Charles V Prizzi Kristina Perkin Davison Alan C. Stephenson, Esq. Peter Quick Eduardo G. Mestre Bruce Stillman, Ph.D. Bruce Stillman, Ph.D. David M. Rubenstein Jerome Swartz, Ph.D. James D. Watson, Ph.D. Bruce Stillman, Ph.D. Roy J. Zuckerberg Roy J. Zuckerberg Audit Dolan DNA Learning Center Lola N. Grace, Chair Robertson Research Fund Arthur M. Spiro Arthur M. Spiro, Chair Carl Schafer,' Chair Alan C. Stephenson, Esq. Marion Wood Ahmed W. Dillaway Ayres, Jr. W. Dillaway Ayres, Jr. Hollis Cline, Ph.D. Development Edward A. Chernoff Lola N. Grace Lola N. Grace Joseph T. Donohue, Chair Eduardo G. Mestre Suzanne Kleinknecht Kristina Perkin Davison Bruce Stillman, Ph.D. Laurie J. Landeau, V.M.D. Laurie J. Landeau, V.M.D. David A. Mick los Robert D. Lindsay Family Representatives Lawrence Scherr, M.D. Nancy Marks Katherine Ernst Bruce Stillman, Ph.D. Thomas C. Quick Walter Meier, M.D. Edward Travaglianti James D. Watson, Ph.D. William S. Robertson Marianne Dolan Weber Roy J. Zuckerberg Tenure and Appointments Higher Education Executive Committee Bruce Stillman, Ph.D., Chair David Botstein, Ph.D. Eduardo G. Mestre, Chair Laurence F. Abbott, Ph.D. Robert D. Lindsay W. Dillaway Ayres, Jr. David Botstein, Ph.D. Alan C. Stephenson, Esq. Joseph T. Donohue Titia de Lange, Ph.D. James M. Stone, Ph.D. Lola N. Grace Susan Lee Lindquist, Ph.D. James D. Watson, Ph.D. Bruce Stillman, Ph.D. Robert E. Wittes, M.D. Edward Travaglianti Research Roy J. Zuckerberg Other Committees Laurence F. Abbott, Ph.D. Finance Holly Cline, Ph.D. Titia de Lange, Ph.D. Lola N. Grace, Chair Building Jacob Goldfield W. Dillaway Ayres, Jr. Arthur Brings Edward Harlow, Ph.D. Jacob Goldfield John R Cleary, Esq. Jeff Hawkins Robert D. Lindsay Helen Ann Dolan Bruce Stillman, Ph.D. William S. Robertson Mary D. Lindsay Robert Tjian, Ph.D. Lad C. Russo Nancy Marks Robert E. Wittes, M.D. Edward Travaglianti Wendy Vander Poel Russell Roy J. Zuckerberg Elizabeth Watson Investment Edward Travaglianti, Chair W. Dillaway Ayres, Jr. `Deceased (2005) vii H. Bentley Glass (1906-2005) H. Bentley Glass, the distinguished geneticist and educator whose intimate involvement with Cold Spring Harbor Laboratory spanned more than 50 years, died on January 16, 2005, one day before he would have celebrated his 99th birthday. Born in Laichoufu, China to Baptist missionary parents, he first came to the United States as a student at Baylor University in Waco, Texas. After graduation, he taught science and coached football for 2 years at Timpson High School, near the Louisiana border, before returning to Baylor for research that led to his master's degree. Already focused on genetics, he moved in 1929 to the University of Texas at Austin for Ph.D. research under the supervision of already famed Drosophila geneticist Herman J. Muller, whose 1926 discovery that X rays induce mutations later led to a 1946 Nobel Prize. Because of his unorthodox social life and left-wing political affiliations, Muller's position as a professor at the University was increasingly unstable, leading to his 1932 move to the Berlin laboratory of Russian-born geneticist, N. Timofeev-Ressovsky. Bentley, whose later career was to mark him as the best of Muller's American stu- dents, used a highly prized National Research Council Postdoctoral Fellowship to also go to Berlin, then the scientific capital of the world. But just before he was to arrive, his potential mentor, the German-Jewish geneticist Curt Stern, fearful that the Nazis would come to power, abruptly decided to remain in the United States.
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