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COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY VOLUME LXX 00_Symp70_frontmatter 5/22/06 12:11 PM Page ii

www.cshl-symposium.org Institutions that have purchased the hardcover edition of this book are entitled to online access to the Symposium Web site. Please contact your institution’s library to gain access to the Web site. The site contains the full text articles from the 2005 Symposium and the Symposia held in 1998–2004 as well as archive photographs and selected papers from the 61-year history of the annual Symposium. If a token number is given above, you will need to activate the token to gain access. If you have previously registered and activated your online account for any prior volume without the use of a token, then you do not have to register again. If you do not have an account number or a token number, or are experiencing access problems, please contact Kathy Cirone, CSHL Press Subscription Manager, at 1-800-843-4388, extension 4044 (Continental U.S. and Canada), 516-422-4100 (All other locations), [email protected], or [email protected]. 00_Symp70_frontmatter 5/22/06 12:11 PM Page iii

COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY VOLUME LXX

Molecular Approaches to Controlling Cancer

www.cshl-symposium.org

Meeting Organized by Bruce Stillman and David Stewart COLD SPRING HARBOR LABORATORY PRESS 2005 00_Symp70_frontmatter 5/22/06 12:11 PM Page iv

COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY VOLUME LXX

©2005 by Cold Spring Harbor Laboratory Press International Standard Book Number 0-87969-773-3 (cloth) International Standard Book Number 0-87969-774-1 (paper) International Standard Serial Number 0091-7451 Library of Congress Catalog Card Number 34-8174

Printed in the United States of America All rights reserved COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY Founded in 1933 by REGINALD G. HARRIS Director of the Biological Laboratory 1924 to 1936 Previous Symposia Volumes

I (1933) Surface Phenomena XXXV (1970) Transcription of Genetic Material II (1934) Aspects of Growth XXXVI (1971) Structure and Function of Proteins at the Three- III (1935) Photochemical Reactions dimensional Level IV (1936) Excitation Phenomena XXXVII (1972) The Mechanism of Muscle Contraction V (1937) Internal Secretions XXXVIII (1973) Chromosome Structure and Function VI (1938) Protein Chemistry XXXIX (1974) Tumor Viruses VII (1939) Biological Oxidations XL (1975) The Synapse VIII (1940) Permeability and the Nature of Cell Membranes XLI (1976) Origins of Lymphocyte Diversity IX (1941) Genes and Chromosomes: Structure and Organization XLII (1977) Chromatin X (1942) The Relation of Hormones to Development XLIII (1978) DNA: Replication and Recombination XI (1946) Heredity and Variation in Microorganisms XLIV (1979) Viral Oncogenes XII (1947) Nucleic Acids and Nucleoproteins XLV (1980) Movable Genetic Elements XIII (1948) Biological Applications of Tracer Elements XLVI (1981) Organization of the Cytoplasm XIV (1949) Amino Acids and Proteins XLVII (1982) Structures of DNA XV (1950) Origin and Evolution of Man XLVIII (1983) Molecular Neurobiology XVI (1951) Genes and Mutations XLIX (1984) Recombination at the DNA Level XVII (1952) The Neuron L (1985) Molecular Biology of Development XVIII (1953) Viruses LI (1986) Molecular Biology of Homo sapiens XIX (1954) The Mammalian Fetus: Physiological Aspects of De- LII (1987) Evolution of Catalytic Function velopment LIII (1988) Molecular Biology of Signal Transduction XX (1955) Population Genetics: The Nature and Causes of Genetic LIV (1989) Immunological Recognition Variability in Population LV (1990) The Brain XXI (1956) Genetic Mechanisms: Structure and Function LVI (1991) The Cell Cycle XXII (1957) Population Studies: Animal Ecology and LVII (1992) The Cell Surface Demography LVIII (1993) DNA and Chromosomes XXIII (1958) Exchange of Genetic Material: Mechanism and Con- LIX (1994) The Molecular Genetics of Cancer sequences LX (1995) Protein Kinesis: The Dynamics of Protein XXIV (1959) Genetics and Twentieth Century Darwinism Trafficking and Stability XXV (1960) Biological Clocks LXI (1996) Function & Dysfunction in the Nervous System XXVI (1961) Cellular Regulatory Mechanisms LXII (1997) Pattern Formation during Development XXVII (1962) Basic Mechanisms in Animal Virus Biology LXIII (1998) Mechanisms of Transcription XXVIII (1963) Synthesis and Structure of Macromolecules LXIV (1999) Signaling and Gene Expression in the Immune System XXIX (1964) Human Genetics LXV (2000) Biological Responses to DNA Damage XXX (1965) Sensory Receptors LXVI (2001) The Ribosome XXXI (1966) The Genetic Code LXVII (2002) The Cardiovascular System XXXII (1967) Antibodies LXVIII (2003) The Genome of Homo sapiens XXXIII (1968) Replication of DNA in Microorganisms LXVIX (2004) Epigenetics XXXIV (1969) The Mechanism of Protein Synthesis

Front Cover (Paperback): Detail of a French anticancer poster, “Vaincre le Cancer,” by Bernard Vellemot (courtesy of the National Library of Medicine). Authorization to photocopy items for internal or personal use, or the internal or personal use of specific clients, is granted by Cold Spring Harbor Laboratory Press, provided that the appropriate fee is paid directly to the Copyright Clearance Center (CCC). Write or call CCC at 222 Rosewood Drive, Danvers, MA 01923 (978-750-8400) for information about fees and regulations. Prior to photocopying items for educational classroom use, contact CCC at the above address. Additional information on CCC can be obtained at CCC Online at http://www.copyright.com/ All Cold Spring Harbor Laboratory Press publications may be ordered directly from Cold Spring Harbor Laboratory Press, 500 Sunnyside Boulevard, Woodbury, NY 11797-2924. Phone: 1-800-843-4388 in Continental U.S. and Canada. All other locations: (516) 422-4100. FAX: (516) 422-4097. E-mail: [email protected]. For a complete catalog of all Cold Spring Harbor Laboratory Press publications, visit our World Wide Web Site http://www.cshlpress.com/ Web Site Access: Institutions that have purchased the hardcover edition of this book are entitled to online access to the companion Web site at www.cshl-symposium.org. For assistance with activation, please contact Kathy Cirone, CSHL Press Subscription Manager, at [email protected]. 00_Symp70_frontmatter 5/22/06 12:11 PM Page v

Symposium Participants

ABATE-SHEN, CORY, Dept. of Medicine, UMDNJ-Robert ATTARDI, LAURA, Dept. of Radiation Oncology, Stanford Wood Johnson Medical School, Piscataway, New Jersey University, Stanford, California ABURATANI, HIROYUKI, Lab. for Systems Biology and AUBIN, REMY, Div. of Cell and Molecular Biology, Medicine, University of Tokyo, Tokyo, Japan Health Products and Food Biologicals Branch, Centre ACKERMAN, ANN for Biologics Research, Health Canada, Ottawa, On- ADAMS, DAVID, Dept. of Informatics, The Wellcome tario, Canada Trust Sanger Institute, Hinxton, Cambridge, United AUSTIN, RICK, Dept. of Biology, Amgen, Inc., South San Kingdom Francisco, California ADAMS, JERRY, Molecular Genetics of Cancer, Walter BADER, ANDREAS, Dept. of Molecular and Experimental and Eliza Hall Institute of Medical Research, Mel- Medicine, The Scripps Research Institute, La Jolla, bourne, Victoria, Australia California AIKHIONBARE, FELIX, Dept. of Medicine, Morehouse BAGCHI, ANINDYA, Cold Spring Harbor Laboratory, Cold School of Medicine, Atlanta, Georgia Spring Harbor, New York AL-HAJJ, MUHAMMAD, Oncology Disease Area, Novartis BAKIN, ANDREI, Dept. of Cancer Genetics, Roswell Park Institutes for BioMedical Research, Cambridge, Mas- Cancer Institute, Buffalo, New York sachusetts BALLESTEROS, ANITA, Cancer Cell, Cell Press, Cam- ALBERTS, BRUCE, Dept. of Biochemistry and Biophysics, bridge, Massachusetts University of California, San Francisco BANSAL, SANJAY, Dept. of Pharmacology and Therapeu- ALLIO, THERESA, Dept. of Mouse Genome Informatics, tics, Roswell Park Cancer Institute, Buffalo, New York The Jackson Laboratory, Bar Harbor, Maine BARBACID, MARIANO, Centro Nacional de investiga- ALLISON, JAMES, Immunology Program, Howard Hughes ciones Ontologica, Madrid, Spain Medical Institute, Memorial Sloan-Kettering Cancer BARGONETTI, JILL, Dept. of Biological Sciences, Hunter Center, New York, New York College, City University of New York, New York AMARIGLIO, NINETTE, Dept. of Pediatric Hematology and BARNHART, BRYAN, Dept. of Cancer Biology, University Oncology, Chaim Sheba Medical Center, Tel of Pennsylvania, Philadelphia Hashomer, Israel BAYLIN, STEPHEN, Oncology Center, Johns Hopkins Uni- AMSON, ROBERT, Dept. of Cancer Research, Molecular versity School of Medicine, Baltimore, Maryland Engines Laboratories, Paris, France BEACHY, PHILIP, Dept. of Molecular Biology and Genet- ANDL, CLAUDIA, Dept. of Medicine and Genetics, Uni- ics, Johns Hopkins University School of Medicine, versity of Pennsylvania, Philadelphia Baltimore, Maryland ANN, DAVID, Dept. of Molecular Pharmacology and Tox- BENEZRA, ROBERT, Dept. of Cell Biology, Memorial icology, University of Southern California, Los Ange- Sloan-Kettering Cancer Center, New York, New York les, California BENTIVEGNA, STEVEN, Dept. of Pharmacogenomics, ANTONOVA, LILIA, Dept. of Pathology and Molecular Pfizer, Inc., Groton, Connecticut Medicine, Queen’s University, Kingston, Ontario, BENTON, GEOFFREY, Dept. of Pathology, University of Canada California, San Francisco ARAI, YOSHIO, Dept. of Radiation Oncology, Veteran’s BENVENUTI, SILVIA, The Oncogenomics Center, Institute Administration Medical Center, University of Pitts- for Cancer Research and Treatment, Candiolo, Torino, burgh, Pittsburgh, Pennsylvania Italy ARMANIOS, MARY, Dept. of Oncology, Johns Hopkins BENZINGER, ANNE, Dept. of Molecular Oncology, Max- University School of Medicine, Baltimore, Maryland Planck-Institute for Biochemistry, Martinsried, Ger- ARNONE, MARC, Dept. of Oncology Biology, Glaxo- many SmithKline, Collegeville, Pennsylvania BERBERICH, MATTHEW, Dept. of Molecular Biophysics ARVA, NICOLETA, Dept. of Biology, Hunter College, City and Biochemistry, Yale University, New Haven, Con- University of New York, New York necticut ASHKENAZI, AVI, Dept. of Molecular Oncology, Genen- BERNARDS, RENÉ, Dept. of Molecular Carcinogenesis, tech, Inc., South San Francisco, California The Netherlands Cancer Institute, Amsterdam, The ASHWORTH, ALAN, The Breakthrough Breast Cancer Re- Netherlands search Centre, Chester Beatty Laboratories, Institute of BERNS, ANTON, Dept. of Molecular Genetics, The Nether- Cancer Research, London, United Kingdom lands Cancer Institute, Amsterdam, The Netherlands ATTAR, RICHARDO, Dept. of Oncology Drug Discovery, BEVERLY, LEVI, Dept. of Molecular and Cellular Oncoge- Bristol-Myers Squibb, Princeton, New Jersey nesis, The Wistar Institute, Philadelphia, Pennsylvania

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vi SYMPOSIUM PARTICIPANTS

BIHANI, TEERU, Dept. of Molecular Pharmacology and Medical School, Lebanon, New Hampshire Cancer Therapeutics, Roswell Park Cancer Institute, CHAN, KELVIN, Dept. of Obstetrics and Gynecology, Uni- Buffalo, New York versity of Hong Kong, Hong Kong BILLOTTET, CLOTILDE, Dept. of Cell Signalling, Ludwig CHEN, EMILY, Dept. of Cell Biology, The Scripps Re- Institute for Cancer Research, London, United King- search Institute, La Jolla, California dom CHEUNG, ANN, Center for Cancer Research, Massachusetts BISHOP, J. MICHAEL, Dept. of Microbiology, University Institute of Technology, Cambridge, Massachusetts of California, San Francisco CHODANKAR, RAJAS, Prostate Cancer Center, Cedars- BISSELL, MINA, Div. of Life Sciences, Lawrence Berke- Sinai Medical Center, Los Angeles, California ley National Laboratory, Berkeley, California CHONG, SHAORONG, Dept. of Research, New England BITTINGER, MARK, Dept. of Target Support and Valida- BioLabs, Inc., Beverly, Massachusetts tion, Merck Research Laboratories, Boston, Mas- CHOU, CHEN-KUNG, Dept. of Life Science, Chang Gung sachusetts University, Tao-Yuan, Taiwan, Republic of China BLANK, JUTTA, Dept. of Discovery Technologies, Novartis COCHRAN, ANDREA, Dept. of Protein Engineering, Institutes for BioMedical Research, Basel, Switzerland Genentech, Inc., South San Francisco, California BLUME-JENSEN, PETER, Dept. of Molecular Oncology, COCHRAN, BRENT, Dept. of Physiology, Tufts University Merck Research Laboratories, Boston, Massachusetts School of Medicine, Boston, Massachusetts BOMMI-REDDY, ARCHANA, Dept. of Medical Oncology, COLLIER, LARA, Dept. of Genetics, Cell Biology and De- Dana-Farber Cancer Institute, Boston, Massachusetts velopment, Cancer Center, University of Minnesota, BORZILLO, GARY, Dept. of Cancer Biology, Pfizer, Inc., Minneapolis Groton, Connecticut COMB, MICHAEL, President, Cell Signaling Technology, BRACHMANN, SASKIA, Dept. of Medical Oncology, Dana- Beverly, Massachusetts Farber Cancer Institute, Boston, Massachusetts CONNELL, LAUREEN, Genes & Development, Cold Spring BRADY, MARK, Dept. of Surgery and Oncology, Univer- Harbor Laboratory Press, Cold Spring Harbor, New sity of Liverpool, Liverpool, United Kingdom York BRAHMBHATT, HIMANSHU, Dept. of Cancer Research, En- COOMBER, DAVID, Institute of Molecular and Cellular Bi- GeneIC Pty, Ltd., Sydney, New South Wales, Australia ology, Proteos, Singapore BRENNER, SYDNEY, The Salk Institute for Biological COOPMAN, PETER, Unité Mixte de Recherche, Centre Na- Studies, La Jolla, California tional de la Recherche Scientifique, University of BRIESEWITZ, ROGER, Dept. of Pharmacology, Ohio State Montpellier, Montpellier, France University, Columbus, Ohio COQUERET, OLIVER, Cancer Center Paul Papin, INSERM, BRUGGE, JOAN, Dept. of Cell Biology, Harvard Medical Angers, France School, Boston, Massachusetts CORMIER, CATHERINE, Cold Spring Harbor Laboratory, BRUMMER, TILMAN, Cancer Research Program, Garvan Cold Spring Harbor, New York Institute of Medical Research, Darlinghurst, Sydney, COURTNEIDGE, SARA, Cell Adhesion and Extracellular New South Wales, Australia Matrix Program, The Burnham Institute, La Jolla, Cal- BURGESS, DARREN, Cold Spring Harbor Laboratory, Cold ifornia Spring Harbor, New York COVELLO, KELLY, Dept. of Cell and Developmental Biol- BURNS, ALEXANDER, Metabolic Diseases Branch, Na- ogy, University of Pennsylvania, Philadelphia tional Institute of Diabetes and Digestive and Kidney CRAWFORD, SARAH, Dept. of Biology, Southern Con- Diseases, National Institutes of Health, Bethesda, necticut State University, New Haven, Connecticut Maryland CRAWFORD, YONGPING, Dept. of Angiogenesis Research, BUTT, ALISON, Cancer Research Program, Garvan Insti- Genentech, Inc., South San Francisco, California tute of Medical Research, Darlinghurst, Sydney, New CULLINAN, EMILY, Dept. of Oncology, Lexicon Genetics, South Wales, Australia Inc., The Woodlands, Texas CAI, WEI-WEN, Dept. of Molecular and Human Genetics, CURTIS, DANIEL, Dept. of Developmental and Molecular Baylor College of Medicine, Houston, Texas Pathways, Novartis Institutes for BioMedical Re- CAMPBELL, ROBERT, Dept. of Scientific Computing, search, Cambridge, Massachusetts Serono Research Institute, Rockland, Massachusetts DACKOUR, RADUWAN, Dept. of Otolaryngology, Long Is- CAMPISI, JUDITH, Div. of Life Sciences, Lawrence Berke- land Jewish Medical Center, New Hyde Park, New York ley National Laboratory, Berkeley, California DAI, CHENGKAI, Whitehead Institute for Biomedical Re- CAO, LIU, Genetics of Development and Diseases search, Cambridge, Massachusetts Branch, National Institute of Diabetes and Digestive DAKIC, ALEKSANDAR, Dept. of Immunology, Walter and and Kidney Diseases, National Institutes of Health, Eliza Hall Institute of Medical Research, Parkville, Bethesda, Maryland Victoria, Australia CAPOBIANCO, ANTHONY, Dept. of Molecular and Cellular DANKORT, DAVID, Cancer Research Institute, Compre- Oncogenesis, The Wistar Institute, Philadelphia, Penn- hensive Cancer Center, University of California, San sylvania Francisco CAPUTTO, BEATRIZ, Dept. of Biological Chemistry, DAS, BIKUL, Dept. of Hematology and Oncology, Hospi- CIQUIBIC, National University of Córdoba, Córdoba, tal for Sick Children, Toronto, Ontario, Canada Argentina DE LANGE, TITIA, Dept. of Cell Biology and Genetics, CARMANY, GEORGE Rockefeller University, New York, New York CARRIERE, CATHERINE, Dept. of Medicine, Dartmouth DEPINHO, RONALD, Dept. of Medical Oncology, Dana- 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Farber Cancer Institute, Boston, Massachusetts versity School of Medicine, New Haven, Connecticut DE SAUVAGE, FREDERIC, Dept. of Molecular Oncology, FOLKMAN, JUDAH, Dept. of Surgery, Children’s Hospital, Genentech, Inc., South San Francisco, California Harvard Medical School, Boston, Massachusetts DEY, ANWESHA, Institute of Molecular and Cell Biology, FOREMAN, KENNETH, Dept. of Cancer Chemistry, OSI Proteos, Singapore Pharmaceuticals, Inc., Farmingdale, New York DICKINS, ROSS, Cold Spring Harbor Laboratory, Cold FOURNIER, ALAINA, Dept. of Pharmacology, University Spring Harbor, New York of Pennsylvania, Philadelphia DILLIN, ANDREW, Lab. of Molecular and Cell Biology, FRIDMAN, JORDAN, Dept. of Preclinical Biology, Incyte The Salk Institute for Biological Studies, La Jolla, Corporation, Wilmington, Delaware California FRIEDMAN, LORI, Dept. of Research, Genentech, Inc., DI MARCOTULLIO, LUCIA, Dept. of Experimental South San Francisco, California Medicine and Pathology, University La Sapienza, FRIEND, STEPHEN, Dept. of Molecular Profiling and Can- Rome, Italy cer Research, Merck Research Laboratories, West DRAETTA, GIULIO, Dept. of Cancer Research, Merck Re- Point, Pennsylvania search Laboratories, Boston, Massachusetts FUTREAL, ANDREW, Cancer Genome Project, The Well- DRAGESET, VILDE, Dept. of Genetics, The Norwegian Ra- come Trust Sanger Institute, Hinxton, Cambridge, dium Hospital, Oslo, Norway United Kingdom DU, YI-CHIEH NANCY, Dept. of Cancer Biology and Ge- GALAKTIONOV, KONSTANTIN, Dept. of Molecular and Hu- netics, Memorial Sloan-Kettering Cancer Center, New man Genetics, Baylor College of Medicine, Houston, York, New York Texas DUAN, ZHENFENG, Dept. of Hematology and Oncology, GALLOWAY, DENISE, Dept. of Cancer Biology, Fred Massachusetts General Hospital, Boston, Massachusetts Hutchinson Cancer Research Center, Seattle, Wash- EBERT, JOAN, Cold Spring Harbor Laboratory Press, ington Woodbury, New York GANN, ALEXANDER, Cold Spring Harbor Laboratory EILERS, MARTIN, Institute of Molecular Biology and Tumor Press, Woodbury, New York Research, University of Marburg, Marburg, Germany GANN, LILIAN, Cold Spring Harbor Laboratory, Cold EINBOND, LINDA, Dept. of Rehabilitation Medicine, Spring Harbor, New York Columbia University, New York, New York GAO, ZHIJIAN, Dept. of Hematology and Oncology, Mas- EISENMAN, ROBERT, Div. of Basic Sciences, Fred Hutchin- sachusetts General Hospital, Boston, Massachusetts son Cancer Research Center, Seattle, Washington GAO, HUI, Biosciences NOVUM, Karolinska Institute, ELLEDGE, STEPHEN, Dept. of Genetics, Harvard Medical Huddinge, Sweden School, Boston, Massachusetts GARY, SYDNEY, Cold Spring Harbor Laboratory, Cold EMERY, CAROLINE, Dept. of Medical Oncology, Dana- Spring Harbor, New York Farber Cancer Institute, Boston, Massachusetts GEIGER, THOMAS, Dept. of Molecular Genetics, The ENOMOTO, TAKEHARU, Lineberger Comprehensive Can- Netherlands Cancer Institute, Amsterdam, The Nether- cer Center, University of North Carolina, Chapel Hill lands EPPING, MIRJAM, Dept. of Molecular Carcinogenesis, The GERHARD, DANIELA, National Cancer Institute, National Netherlands Cancer Institute, Amsterdam, The Nether- Institutes of Health, Bethesda, Maryland lands GIBSON, NEIL, Dept. of Research, OSI Pharmaceuticals, EPSTEIN, CHARLES, Cambridge Genomics Center, Sanofi- Inc., Farmingdale, New York Aventis, Cambridge, Massachusetts GIL, GERMAN, Dept. of Pediatrics, Robert Wood Johnson ERDMANN, DIRK, Dept. of Oncology, Novartis Pharma Medical School, Cancer Institute of New Jersey, New AG, Basel, Switzerland Brunswick, New Jersey ERNKVIST, MIRA, Dept of Oncology and Pathology, GIL, JESUS, Cold Spring Harbor Laboratory, Cold Spring Karolinska Institute, Stockholm, Sweden Harbor, New York EVAN, GERARD, Dept. of Cellular and Molecular Pharma- GIRNUN, GEOFFREY, Dept. of Cancer Biology, Dana-Far- cology, Cancer Research Institute, Comprehensive ber Cancer Institute, Harvard Medical School, Boston, Cancer Center, University of California, San Francisco Massachusetts FAGA, GIOVANNI, Dept. of Experimental Oncology, Eu- GODBOLE, MADAN, Dept. of Endocrinology, Sanjay ropean Institute of Oncology, Milan, Italy Gandhi Postgraduate Institute of Medical Sciences, FAN, HUNG, Dept. of Molecular Biology and Biochem- Lucknow, India istry, Cancer Research Institute, University of Califor- GOELET, PHILLIP, Road to the Cure, San Diego, California nia, Irvine GOLDBERG, ITZHAK, Dept. of Radiation Oncology, Long Is- FEINBERG, ANDREW, Epigenetics Unit, Johns Hopkins land Jewish Medical Center, New Hyde Park, New York University School of Medicine, Baltimore, Maryland GONZALEZ, MICHAEL, Medical Research Council Cancer FERBEYRE, GERARDO, Dept. of Biochemistry, Université Cell Unit, Hutchison/MRC Research Centre, Cam- de Montréal, Montréal, Québec, Canada bridge, United Kingdom FERO, MATTHEW, Div. of Clinical Research, Fred Hutchin- GORDAN, JOHN, Abramson Family Cancer Research In- son Cancer Research Center, Seattle, Washington stitute, University of Pennsylvania, Philadelphia, FLANNERY, ANGELA, Dept. of Genetic Research and Devel- Pennsylvania opment, AstraZeneca, Macclesfield, United Kingdom GOROVITS, NAIRA, Cold Spring Harbor Laboratory, Cold FLAVELL, MADLYN, Guilford, Connecticut Spring Harbor, New York FLAVELL, RICHARD, Dept. of Immunobiology, Yale Uni- GORRINI, CHIARA, Dept. of Experimental Oncology, 00_Symp70_frontmatter 5/22/06 12:11 PM Page viii

viii SYMPOSIUM PARTICIPANTS

European Institute of Oncology, Milan, Italy HARRIS, CRAFFORD, Dept. of Drug Discovery, R.W. GRADI, ALESSANDRA, Dept. of Molecular Oncogenesis, Johnson Pharmaceutical Research Institute, Raritan, Regina Elena Cancer Institute, Rome, Italy New Jersey GRAEBER, THOMAS, Dept. of Molecular and Medical HE, LIN, Cold Spring Harbor Laboratory, Cold Spring Pharmacology, University of California, Los Angeles Harbor, New York GRAHAM, ROBERT, Victor Chang Cardiac Research Insti- HEMANN, MICHAEL, Cold Spring Harbor Laboratory, tute, Darlinghurst, Sydney, Australia Cold Spring Harbor, New York GRAUSENBURGER, REINHARD, Dept. of Medical Biochem- HERBERT, TASINO, Dept. of Biology, Southern Connecti- istry, Medical University of Vienna, Vienna, Austria cut State University, New Haven, Connecticut GRAY, JOE, Lawrence Berkeley National Laboratory, HERGOVICH LISZTWAN, JOANNA, Novartis Pharma AG, Berkeley, California and University of California, San Basel, Switzerland Francisco HERMAN, JAMES, Bunting Blaustern Cancer Research GREIDER, CAROL, Dept. of Molecular Biology and Genet- Center, Sidney Kimmel Comprehensive Cancer Cen- ics, Johns Hopkins University School of Medicine, ter, Johns Hopkins University School of Medicine, Baltimore, Maryland Baltimore, Maryland GROSSEL, MARTHA, Dept. of Zoology, Connecticut Col- HERMEKING, HEIKO, Dept. of Molecular Oncology, Max- lege, New London, Connecticut Planck-Institute for Biochemistry, Martinsried, Ger- GRUBER, MICHAELA, Abramson Family Cancer Research many Institute, University of Pennsylvania, Philadelphia HERSCHKOWITZ, JASON, Dept. of Genetics and Molecular GRUBOR, VLADIMIR, Cold Spring Harbor Laboratory, Biology, University of North Carolina, Chapel Hill Cold Spring Harbor, New York HEUER, TIMOTHY, Dept. of Cellular Pharmacology, Ex- GRUENEBERG, DORRE, RNAi Consortium, Broad Insti- elixis, Inc., South San Francisco, California tute, Massachusetts Institute of Technology, Cam- HICKEY, MICHELE, Dept. of Cell and Molecular Biology, bridge, Massachusetts University of Pennsylvania, Philadelphia GUARDIOLA-SERRANO, FRANCISCA, Dept. of Molecular HICKS, JAMES, Cold Spring Harbor Laboratory, Cold Hematology, University of Frankfurt Medical School, Spring Harbor, New York Frankfurt am Main, Germany HILL, REGINALD, Dept. of Genetics, Lineberger Compre- GUO, BING, Dept. of Oncology Research, Wyeth, Pearl hensive Cancer Center, University of North Carolina, River, New York Chapel Hill GUO, AILAN, Dept. of Research, Cell Signaling Technol- HILLAN, KENNETH, Dept. of Research, Genentech, Inc., ogy, Beverly, Massachusetts South San Francisco, California GUPTA, PIYUSH, Dept. of Biology, Whitehead Institute for HIPPO, YOSHITAKA, Cold Spring Harbor Laboratory, Cold Biomedical Research, Massachusetts Institute of Tech- Spring Harbor, New York nology, Cambridge, Massachusetts HOFFMANN, INGRID, Dept. of Cell Cycle Control and Car- HA, TAEKJIP, Dept. of Physics, University of Illinois, cinogenesis, German Cancer Research Center, Heidel- Urbana berg, Germany HABER, DANIEL, Cancer Center, Massachusetts General HOHENADL, CHRISTINE, Research Institute of Virology Hospital, Charlestown, Massachusetts and Biomedicine, University of Veterinary Medicine, HABIB, TANIA, Dept. of Comparative Medicine, Univer- Vienna, Austria sity of Washington, Seattle HOLST, CHARLES, Dept. of Molecular Oncology, Genen- HAGEMEIER, CHRISTIAN, Children’s Hospital, Charité, tech, Inc., South San Francisco, California Humboldt-University, Berlin, Germany HU, ZHIYUAN, Dept. of Genetics, Lineberger Compre- HAHN, MEINHARD, Dept. of Molecular Genetics, German hensive Cancer Center, University of North Carolina, Cancer Research Center, Heidelberg, Germany Chapel Hill HALEY, JOHN, Dept. of Translational Research, OSI Phar- HUANG, CHI-YING, Dept. of Molecular and Genomic maceuticals, Inc., Farmingdale, New York Medicine, National Health Research Institutes, Zhu- HALL, MARK, Dept. of Biochemistry, St. Jude Children’s nan, Taiwan, Republic of China Research Hospital, Memphis, Tennessee HUANG, FEI, Dept. of Oncology Biomarkers and Clinical HALL, IRA, Cold Spring Harbor Laboratory, Cold Spring Discovery Technology, Bristol-Myers Squibb, Prince- Harbor, New York ton, New Jersey HAMLIN, JOYCE, Dept. of Biochemistry and Molecular HUGHES, CHRISTINA, Dept. of Medical Oncology, Dana- Genetics, School of Medicine, University of Virginia, Farber Cancer Institute, Boston, Massachusetts Charlottesville IACOVIDES, DEMETRIS, Comprehensive Cancer Center, HAN, TAE-HEE, Dept. of Molecular Cell Biology, University of California, San Francisco Sungkyunkwan University School of Medicine, Su- IANARI, ALESSANDRA, Dept. of Experimental Medicine won, South Korea and Pathology, University La Sapienza, Rome, Italy HANAHAN, DOUGLAS, Dept. of Biochemistry and Bio- IGGO, RICHARD, Dept. of Molecular Oncology, Swiss In- physics, University of California, San Francisco stitute for Experimental Cancer Research, Epalinges, HANNON, GREGORY, Cold Spring Harbor Laboratory, Switzerland Cold Spring Harbor, New York INGLIS, JOHN, Cold Spring Harbor Laboratory Press, HARLOW, ED, Dept. of Biological Chemistry and Molec- Woodbury, New York ular Pharmacology, Harvard University School of ISHIDA, SEIKO, Dept. of Biochemistry, Comprehensive Medicine, Boston, Massachusetts Cancer Center, University of California, San Francisco 00_Symp70_frontmatter 5/22/06 12:11 PM Page ix

SYMPOSIUM PARTICIPANTS ix

ISHOV, ALEXANDER, Dept. of Anatomy and Cell Biology, Institute for Biological Studies, La Jolla, California University of Florida, Gainesville KARRETH, FLORIAN, Abramson Family Cancer Research ITO, YOSHIAKI, RUNX Study Group, Institute of Molecu- Institute, University of Pennsylvania, Philadelphia lar and Cell Biology, Proteos, Singapore KASTAN, MICHAEL, Dept. of Hematology and Oncology, ITOH, REINA, Dept. of Tumor Virology, Research Insti- St. Jude Children’s Research Hospital, Memphis, Ten- tute for Microbial Disease, Osaka University, Osaka, nessee Japan KENNY, PARAIC, Div. of Life Sciences, Lawrence Berke- IWAKUMA, TOMOO, Dept. of Molecular Genetics, M.D. An- ley National Laboratory, Berkeley, California derson Cancer Center, University of Texas, Houston KIBERSTIS, PAULA, Science, American Association for the IWATA, KENNETH, Dept. of Cancer Research, OSI Phar- Advancement of Science, Washington, D.C. maceuticals, Inc., Uniondale, New York KIM, JIYOUNG, Dept. of Biochemistry, Tufts University JACKS, TYLER, Center For Cancer Research, Howard School of Medicine, Boston, Massachusetts Hughes Medical Institute, Massachusetts Institute of KIM, MARIANNE, Dept. of Medicine, Mount Sinai School Technology, Cambridge, Massachusetts of Medicine, New York, New York JAKUBCZAK, JOHN, Pfizer Global Research and Develop- KING, MARY-CLAIRE, Div. of Medical Genetics, Univer- ment, Pfizer, Inc., Groton, Connecticut sity of Washington, Seattle JANE-VALBUENA, JUDIT, Dept. of Medical Oncology, KIVIHARJU, TAIJA, Molecular Cancer Biology Program, Dana-Farber Cancer Institute, Boston, Massachusetts University of Helsinki, Helsinki, Finland JAT, PAMJIT, Dept. of Neurodegenerative Disease, Insti- KIYOKAWA, ETSUKO, Dept. of Tumor Virology, Research tute of Neurology, University College, London, United Institute for Bacterial Diseases, University of Osaka, Kingdom Osaka, Japan JECHLINGER, MARTIN, Dept. of Cancer Biology and Ge- KOGISO, TOMOMI, International Medical Center of Japan, netics, Memorial Sloan-Kettering Cancer Center, New Tokyo, Japan York, New York KONDURI, SANTHI, Dept. of Pharmacology and Therapeu- JI, PENG, Dept. of Developmental and Molecular Biol- tics, Roswell Park Cancer Instititute, Buffalo, New ogy, Albert Einstein College of Medicine, Bronx, New York York KOTANIDES, HELEN, Dept. of Molecular and Cell Biol- JOHNSON, LEISA, Dept. of Molecular Biology, Genentech, ogy, ImClone Systems, Inc., New York, New York Inc., South San Francisco, California KRUCHER, NANCY, Dept. of Biology, Pace University, JOHNSON, MARK Pleasantville, New York JOHNSON, TOM, Dept. of Radiation Oncology, Stanford KUILMAN, THOMAS, Dept. of Molecular Genetics, The University, Stanford, California Netherlands Cancer Institute, Amsterdam, The Nether- JOUKOV, VLADIMIR, Dept. of Cancer Biology, Dana-Far- lands ber Cancer Institute, Boston, Massachusetts KUMAR, CHANDRA, Dept. of Tumor Biology, Schering- JOYCE, JOHANNA, Dept. of Cancer Biology and Genetics, Plough Research Institute, Kenilworth, New Jersey Memorial Sloan-Kettering Cancer Center, New York, KURKI, SARI, Molecular Cancer Biology Program, Uni- New York versity of Helsinki, Helsinki, Finland JUNTTILA, MELISSA, Dept. of Medical Biochemistry, Uni- LADANYI, MARC, Dept. of Pathology, Memorial Sloan- versity of Turku, Turku, Finland Kettering Cancer Center, New York, New York KACZMAREK, LEONARD, Dept. of Pharmacology, Yale LAMONTAGNE, KENNETH, Drug Discovery, Johnson and University School of Medicine, New Haven, Con- Johnson Pharmaceutical Research and Development, necticut Raritan, New Jersey KAELIN, WILLIAM, Dept. of Adult Oncology, Dana-Far- LANDER, ERIC, The Broad Institute, Massachusetts Insti- ber Cancer Institute, Boston, Massachusetts tute of Technology, Cambridge, Massachusetts KAKUMOTO, KYOKO, Dept. of Molecular Oncology, LANE, KEARA, Center for Cancer Research, Mas- Osaka Bioscience Institute, Osaka, Japan sachusetts Institute of Technology, Cambridge, Mas- KALLURI, RAGHU, Dept. of Medicine, Beth Israel Dea- sachusetts coness Medical Center, Boston, Massachusetts LANE, DAVID, Executive Director, Institute of Molecular KALPANA, GANJAM, Dept. of Molecular Genetics, Albert and Cell Biology, Proteos, Singapore Einstein College of Medicine, Bronx, New York LEE, CHANG WOO, Research Institute, National Cancer KALRA, DEEPAK, Dept. of Cardiology, Children’s Hospi- Center, Goyang, South Korea tal, Harvard Medical School, Boston, Massachusetts LEE, SOYOUNG, Dept. of Hematology and Oncology, KAMATA, TOHRU, Dept. of Molecular Biology and Bio- Charité, Universitätsmedizin Berlin, Berlin, Germany chemistry, Shinshu University School of Medicine, LEES, JACQUELINE, Dept. of Biology, Center for Cancer Matsumoto, Japan Research, Massachusetts Institute of Technology, KAN, JULIE, Dept. of Cancer Biology, OSI Pharmaceuti- Cambridge, Massachusetts cals, Inc., Farmingdale, New York LEHMKUHL, KRISTINA, Dept. of Biological Sciences, Ohio KANG, HYUNG-GYOO, Dept. of Pathology, Children’s University, Athens, Ohio Hospital, University of Southern California, Los An- LENG, MEI, Dept. of Biochemistry, Baylor College of geles, California Medicine, Houston, Texas KANNIUS-JANSON, MARIE, Dept. of Cell and Molecular LEPRINCE, DOMINIQUE, Lille Institute of Biology, Centre Biology, Gothenburg University, Gothenburg, Sweden National de la Recherche Scientifique, Lille, France KARLSEDER, JAN, Dept. of Regulatory Biology, The Salk LETAI, ANTHONY, Dept. of Medical Oncology, Dana- 00_Symp70_frontmatter 5/22/06 12:11 PM Page x

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Farber Cancer Institute, Boston, Massachusetts MARCUS, EMILIE, Cell, Cell Press, Cambridge, Mas- LEVINE, ARNOLD, School of Natural Sciences, Institute sachusetts for Advanced Studies, Princeton, New Jersey MARGALIT, OFER, Dept. of Pediatric Hematology and On- LI, XINGNAN, Dept. of Cell Biology, University of Al- cology, Chaim Sheba Medical Center, Tel-Hashomer, abama, Birmingham Israel LI, RONG, Dept. of Biochemistry and Molecular Genet- MARINE, JEAN-CHRISTOPHE, Lab. for Molecular Cancer ics, University of Virginia, Charlottesville Biology, Flanders Interuniversity Institute for Biotech- LIN, ATHENA, Dept. of Pharmacology and Therapeutics, nology, Ghent, Belgium Roswell Park Cancer Institute, Buffalo, New York MARKOVINA, STEPHANIE, Dept. of Medicine and Hema- LIN, LING, Metabolic Diseases Branch, National Institute tology, University of Wisconsin, Madison of Diabetes and Digestive and Kidney Diseases, Na- MARSHALL, DEBORAH, Dept. of Oncology Research, Cen- tional Institutes of Health, Bethesda, Maryland tocor, Inc., Radnor, Pennsylvania LINDEMANN, RALPH, Lab. of Gene Regulation, Cancer MARTE, BARBARA, Nature, Nature Publishing Group, Immunology Program, Peter MacCallum Cancer Cen- London, United Kingdom tre, East Melbourne, Victoria, Australia MARTIN, STEVEN, Dept. of Molecular and Cell Biology, LIU, HUIPING, Ben May Institute for Cancer Research, University of California, Berkeley University of Chicago, Chicago, Illinois MARTINS, CARLA, Comprehensive Cancer Center, Uni- LIU, JIANHONG, Dept. of Biology, MethylGene, Inc., versity of California, San Francisco Montréal, Québec, Canada MASSAGUÉ, JOAN, Dept. of Cell Biology, Genetics Pro- LIU, KUN-HSIANG, Dept. of Genomics, Biomedical Engi- gram, Memorial Sloan-Kettering Cancer Center, New neering Center, Industrial Technology Research Insti- York, New York tute, Hsinchu, Taiwan, Republic of China MASUDA, KAZUHIRO, BioFrontier Laboratories, Kyowa LIU, XIANGDONG, Dept. of Drug Discovery and Develop- Hakko Kogyo Co., Ltd., Tokyo, Japan ment, Incyte Corporation, Wilmington, Delaware MATAPURKAR, ANAGHA, Cold Spring Harbor Laboratory, LIU, XUESONG, Dept. of Cancer Research, Abbott Labo- Cold Spring Harbor, New York ratories, Abbott Park, Illinois MAZUREK, ANTHONY, Cold Spring Harbor Laboratory, LIU, XUESONG, Dept. of Oncology, Lexicon Genetics, Cold Spring Harbor, New York Inc., The Woodlands, Texas MCCORMICK, FRANK, Cancer Research Institute, Com- LIU, YING, Dept. of Cancer and Immunogenetics, prehensive Cancer Center, University of California, Weatherall Institute of Molecular Medicine, J.R. Hos- San Francisco pital, Oxford, United Kingdom MCLEAN, ADELE, Dept. of Molecular Genetics, Institute LIU, ZHAOLI, Dept. of Cell Biology, University of Al- of Biomedical and Life Sciences, University of Glas- abama, Birmingham gow, Glasgow, Scotland, United Kingdom LIVINGSTON, DAVID, Dept. of Cancer Biology, Dana-Far- MCMAHON, MARTIN, Cancer Research Institute, Com- ber Cancer Institute, Harvard School of Medicine, prehensive Cancer Center, University of California, Boston, Massachusetts San Francisco LOWE, SCOTT, Howard Hughes Medical Institute, Cold MEANI, NATALIA, FIRC Institute of Molecular Oncology Spring Harbor Laboratory, Cold Spring Harbor, New Foundation, European Institute of Oncology, Milan, York Italy LU, XIN, Dept. of Molecular Biology, Princeton Univer- MEDICO, ENZO, Institute for Cancer Research and Treat- sity, Princeton, New Jersey ment, University of Torino School of Medicine, Can- LU, XIN, Lab. of Tumour Suppression, Ludwig Institute diolo, Torino, Italy for Cancer Research, London, United Kingdom MELLMAN, IRA, Dept. of Cell Biology, Yale University LUCIANI, GLORIA, Dept. of Internal Medicine, Medical School of Medicine, New Haven, Connecticut University of Vienna, Vienna, Austria MENDOZA, MICHAEL, Div. of Digestive Diseases, Univer- LUK, JOHN, Dept. of Surgery, University of Hong Kong, sity of California, Los Angeles Hong Kong MENON, RADHA, Dept. of Immunology and Molecular Di- LYONS, JESSE, Comprehensive Cancer Center, Univer- agnostics, Federal Drug Administration, Rockville, sity of California, San Francisco Maryland LÜSCHER, BERNHARD, Dept. of Biochemistry and Molec- MEYERSON, MATTHEW, Dept. of Molecular Oncology, ular Biology, RWTH University, Aachen, Germany Dana-Farber Cancer Institute, Boston, Massachusetts MACDIARMID, JENNIFER, Dept. of Cancer Research, En- MILLER, ABIGAIL, Cancer Research Institute, Compre- GeneIC Pty, Ltd., Sydney, New South Wales, Australia hensive Cancer Center, University of California, San MACDONALD, GWEN, Dept. of Biochemistry, Cancer Re- Francisco search Institute, Queen’s University, Kingston, On- MILLS, ALEA, Cold Spring Harbor Laboratory, Cold tario, Canada Spring Harbor, New York MACLEOD, KAY, Ben May Institute for Cancer Research, MIRANTI, CINDY, Dept. of Microbiology,Van Andel Re- University of Chicago, Chicago, Illinois search Institute, Grand Rapids, Michigan MAJID, ANEELA, Toxicology Unit, Medical Research MISCHEK, DANIELA, Research Institute of Virology and Council, Leicester, United Kingdom Biomedicine, University of Veterinary Medicine, MAJUMDER, SADHAN, Dept. of Molecular Genetics, M.D. Vienna, Austria Anderson Cancer Center, University of Texas, Houston MITRA, KOYEL, Dept. of Molecular Genetics, Albert Ein- 00_Symp70_frontmatter 5/22/06 12:11 PM Page xi

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stein College of Medicine, Bronx, New York Spring Harbor, New York MITTAL, VIVEK, Cold Spring Harbor Laboratory, Cold OH, HYUN JUNG, Dept. of Biological Sciences, Korea Ad- Spring Harbor, New York vanced Institute of Science and Technology, Daejeon, MOHI, M. GOLAM, Dept. of Medicine, Div. of Hematol- South Korea ogy and Oncology, Beth Israel Deaconess Medical OH, SANG-PHIL, Dept. of Biological Sciences, Korea Ad- Center, Boston, Massachusetts vanced Institute of Science and Technology, Daejeon, MONKKONEN, MIA, Molecular Cancer Biology Program, South Korea University of Helsinki, Helsinki, Finland OHTA, NORIO, BioFrontier Laboratories, Kyowa Hakko MOORES, SHERI, Dept. of Oncology and Supportive Care, Kogyo Co., Ltd., Tokyo, Japan GlaxoSmithKline, Collegeville, Pennsylvania OLIVE, KENNETH, Abramson Family Cancer Research In- MORFORD, LORRI, Dept. of Microbiology, Immunology and stitute, University of Pennsylvania, Philadelphia Molecular Genetics, University of Kentucky, Lexington OLOFSSON, BEATRIX, Dept. of Biochemistry, Drexel Uni- MORI, SEIICHI, Institute for Genome Sciences and Policy, versity College of Medicine, Philadelphia, Pennsylvania Duke University, Durham, North Carolina ONEYAMA, CHITOSE, Lab. of Molecular Oncology, Osaka MORONI, MARIA CRISTINA, Dept. of Experimental Oncol- Bioscience Institute, Osaka, Japan ogy, European Institute of Oncology, Milan, Italy OPAVSKY, RENE, Dept. of Human Cancer Genetics, Ohio MORRISON, DEBRA, Dept. of Medicine, Mount Sinai State University, Columbus, Ohio School of Medicine, New York, New York O’SHEA, CLODAGH, Comprehensive Cancer Center, Uni- MORRISON, SEAN, Howard Hughes Medical Institute, versity of California, San Francisco University of Michigan, Ann Arbor OZER, HARVEY, University Hospital Cancer Center, MROCZKOWSKI, BARBARA, Dept. of Structural Biology, UMDNJ-New Jersey Medical School, Newark, New Pfizer Global Research and Development, Pfizer, Inc., Jersey San Diego, California PALAKURTHI, SANGEETHA, Dept. of Cancer Bioscience, MU, DAVID, Cold Spring Harbor Laboratory, Cold Spring AstraZeneca, Waltham, Massachusetts Harbor, New York PANDOLFI, PIER-PAOLO, Memorial Sloan-Kettering Can- MUJTABA, SYED, Dept. of Physiology and Biophysics, cer Center, New York, New York Mount Sinai School of Medicine, New York, New York PAPAGEORGIS, PANAGIOTIS, Dept. of Genetics and Ge- MURPHY, DANIEL, Cancer Research Institute, Compre- nomics, Boston University School of Medicine, hensive Cancer Center, University of California, San Boston, Massachusetts Francisco PARADA, LUIS, Center for Developmental Biology, South- MUTHUSWAMY, SENTHIL, Cold Spring Harbor Labora- western Medical Center, University of Texas, Dallas tory, Cold Spring Harbor, New York PARK, JAEHONG, Dept. of Biological Chemistry and MYSINGER, CYNTHIA, Cancer Research Institute, Univer- Molecular Pharmacology, Institute of Proteomics, sity of California, San Francisco Harvard Medical School, Cambridge, Massachusetts NAGAHARA, HIKARU, Sanno Hospital, International Uni- PAVLETICH, NIKOLA, Structural Biology Program, Memorial versity of Health and Welfare, Tokyo, Japan Sloan-Kettering Cancer Center, New York, New York NAHLE, ZAHER, Dept. of Internal Medicine, Washington PENDE, MARIO, Necker Institute, INSERM, Paris, France University, St. Louis, Missouri PERSSON, JENNY, Dept. of Laboratory Medicine, Div. of NAKADA, DAISUKE, Div. of Biological Science, Nagoya Pathology, Lund University, Malmö, Sweden University Graduate School of Science, Nagoya, Japan PERVIN, SHEHLA, Dept. of Obstetrics and Gynecology, NAKADE, KOJI, BioResource Center, RIKEN, Ibaraki, University of California, Los Angeles Japan PETERS, GORDON, Dept. of Molecular Oncology, London NAKAGAMA, HITOSHI, Div. of Biochemistry, National Research Institute, London, United Kingdom Cancer Center Research Institute, Tokyo, Japan PETERSON, JANE, Div. of Extramural Research, National NARAMURA, MAYUMI, Dept. of Medicine, ENH Research Human Genome Research Institute, National Institutes Institute, Evanston, Illinois of Health, Bethesda, Maryland NARITA, MASAKO, Cold Spring Harbor Laboratory, Cold PHAN, VERNON, Cancer Research Institute, Comprehen- Spring Harbor, New York sive Cancer Center, University of California, San NARITA, MASASHI, Cold Spring Harbor Laboratory, Cold Francisco Spring Harbor, New York PHILBRICK, WILLIAM, Technical Advisory Committee, NAVIN, NICHOLAS, Cold Spring Harbor Laboratory, Cold Yale University School of Medicine, New Haven, Spring Harbor, New York Connecticut NEILL, USHMA, Journal of Clinical Investigation, PICCINI, ANTONELLA, Cold Spring Harbor Laboratory, Columbia University, New York, New York Cold Spring Harbor, New York NICASSIO, FRANCESCO, FIRC Institute Molecular Oncol- PICKERING, CURTIS, Dept. of Pathology, University of ogy Foundation, European Institute of Oncology, California, San Francisco Milan, Italy PIERCE, AISLING, Dept. of Molecular Biology, National NILSSON, JEANETTE, Dept. of Cell and Molecular Biol- Institute for Cellular Biotechnology, Dublin City Uni- ogy, Gothenburg University, Gothenburg, Sweden versity, Dublin, Ireland NOLAN, DANIEL, Cold Spring Harbor Laboratory, Cold PODSYPANINA, KATRINA, Dept. of Cell Biology, Memo- Spring Harbor, New York rial Sloan-Kettering Cancer Center, New York, New NUNEZ, SABRINA, Cold Spring Harbor Laboratory, Cold York 00_Symp70_frontmatter 5/22/06 12:11 PM Page xii

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POLAKIEWICZ, ROBERTO, Dept. of Research, Cell Signal- Genomics Institute of the Novartis Research Founda- ing Technology, Beverly, Massachusetts tion, San Diego, California POLITI, KATERINA, Dept. of Cancer Biology and Genetics, ROZENBLATT-ROSEN, ORIT, Dept. of Molecular Oncol- Memorial Sloan-Kettering Center, New York, New ogy, Dana-Farber Cancer Institute, Boston, Mas- York sachusetts POLLOCK, MILA, Cold Spring Harbor Laboratory Library, RUEFLI-BRASSE, ASTRID, Dept. of Biology, Amgen, Inc., Cold Spring Harbor, New York South San Francisco, California PONDER, BRUCE, Dept. of Oncology, Hutchison/MRC RUGGIERI, ROSAMARIA, Dept. of Oncology and Cell Biol- Research Centre, Cambridge, United Kingdom ogy, North Shore-Long Island Jewish Institute for POORTINGA, GRETCHEN, Div. of Research, Peter MacCal- Medical Research, Manhasset, New York lum Cancer Centre, East Melbourne, Victoria, Aus- RUSSO, GIAN-LUIGI, Dept. of Biochemistry, Istituto tralia Scienze dell’Alimentazione, Avellino, Italy PORTER, JESS, School of Medicine, University of Penn- RYEOM, SANDRA, Dept. of Cell Biology, Harvard Univer- sylvania, Philadelphia sity School of Medicine, Boston, Massachusetts POWERS, SCOTT, Cold Spring Harbor Laboratory, Cold SABAPATHY, KANAGA, Div. of Cellular and Molecular Spring Harbor, New York Research, National Cancer Centre, Singapore PRIVES, CAROL, Dept. of Biological Sciences, Columbia SACCHI, NICOLETTA, Dept. of Cancer Genetics, Roswell University, New York, New York Park Cancer Institute, Buffalo, New York QIAN, YUEWEI, Lilly Research Laboratories, Eli Lilly and SAFRAN, MICHAL, Dept. of Adult Oncology, Dana-Farber Company, Indianapolis, Indiana Cancer Institute, Boston, Massachusetts QUON, KIM, Dept. of Biology, Amgen, Inc., South San SAITO, TSUYOSHI, Dept. of Pathology, Memorial Sloan- Francisco, California Kettering Cancer Center, New York, New York RABBITTS, PAMELA, Dept. of Medicine, Medical School, SANSAL, ISABELLE, Dept. of Medical Oncology, Dana- University College, London, United Kingdom Farber Cancer Institute, Boston, Massachusetts RABBITTS, TERENCE, Lab. of Molecular Biology, Medical SANTARIUS, THOMAS, Cancer Genome Project, The Well- Research Council, Cambridge, United Kingdom come Trust Sanger Institute, Hinxton, Cambridge, RABINOVSKY, ROSALIA, Dept. of Medical Oncology, United Kingdom Dana-Farber Cancer Institute, Boston, Massachusetts SAPLIS, RACHEL, Dept. of Genetics, Cellular Biology, and RAFFANIELLO, ROBERT, Dept. of Medical Laboratory Sci- Development, Cancer Center, University of Min- ences, School of Health Professions, Hunter College, nesota, Minneapolis City University of New York, New York SARAMAKI, OUTI, Dept. of Cancer Genetics, Institute of RAMSEY, MATTHEW, Dept. of Genetics, University of Medical Technology, University of Tampere, Tam- North Carolina, Chapel Hill pere, Finland RAUCH, JENS, Molecular Oncology Clinical Cooperation SAUNDERS, DARREN, Cancer Research Program, Garvan Group, Ludwig-Maximilians University of Munich, Institute of Medical Research, Darlinghurst, Sydney, Munich, Germany New South Wales, Australia RAUHALA, HANNA, Institute of Medical Technology, Uni- SAUNUS, JODI, School of Molecular and Microbial Sci- versity of Tampere, Tampere, Finland ences, University of Queensland, St. Lucia, Australia RECHAVI, GIDEON, Dept. of Pediatric Hematology and SAWYERS, CHARLES, Dept. of Medicine, University of Oncology, Chaim Sheba Medical Center, Tel- California, Los Angeles Hashomer, Israel SAYEED, SHEIKH, Dept. of Pharmacology and Therapeu- REPELLIN, CLAIRE, Dept. of Molecular Genetics, Univer- tics, Roswell Park Cancer Institute, Buffalo, New York sity of Glasgow,Glasgow, Scotland, United Kingdom SCHAFFER, JAMES, Dept. of Healthcare Information Tech- RICHARDSON, CELESTE, Dept. of Oncology, Novartis In- nology, Philips Research, Briarcliff Manor, New York stitutes for BioMedical Research, Cambridge, Mas- SCHLEGEL, ROBERT, Dept. of Oncology, Novartis Insti- sachusetts tutes for BioMedical Research, Cambridge, Mas- RICHMOND, JODI, Dept. of Pharmacogenomics, Pfizer, sachusetts Inc., Groton, Connecticut SCHLIEKELMAN, MARK, Dept. of Genetics, University of RIKOVA, KLARISA, Dept. of Research, Cell Signaling North Carolina, Chapel Hill Technology, Beverly, Massachusetts SCHMITT, CLEMENS, Dept. of Hematology and Oncology, ROBERTS, CHARLES, Dept. of Pediatric Oncology, Dana- Max-Delbrück-Center for Molecular Medicine, Farber Cancer Institute, Boston, Massachusetts Berlin, Germany ROCHE, SERGE, Centre de Recherches de Biochimie SCHNEIDER, GÜNTER, Dept. of Internal Medicine, Techni- Macromoléculaire, Centre National de la Recherche cal University of Munich, Munich, Germany Scientifique, Montpellier, France SCHUBERT, CHARLOTTE, Nature Medicine, Nature Pub- RODRIGUEZ, ELENA, Dept. of Molecular and Cell Biol- lishing Group, New York, New York ogy, University of California, Berkeley SCHWEIZER, LIANG, Dept. of Oncology Drug Discovery, RODRIGUEZ, ROBERTO, Dept. of Vascular Biology, Chil- Bristol-Myers Squibb, Princeton, New Jersey dren’s Hospital, Boston, Massachusetts SCOTT, CLARE, Cold Spring Harbor Laboratory, Cold ROOF, DAVID, Dept. of Molecular and Cell Biology, Cy- Spring Harbor, New York tokinetics, Inc., South San Francisco, California SEBASTIAN, THOMAS, Lab. of Protein Dynamics and Sig- ROTTMANN, SABINE, Dept. of Cell and Cancer Biology, naling, National Cancer Institute, Frederick, Maryland 00_Symp70_frontmatter 5/22/06 12:11 PM Page xiii

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SELIVANOVA, GALINA, Microbiology and Tumor Biology Netherlands Cancer Institute, Amsterdam, The Nether- Center, Karolinska Institute, Stockholm, Sweden lands SELLERS, WILLIAM, Div. of Neoplastic Disease Mecha- SPECTOR, DAVID, Cold Spring Harbor Laboratory, Cold nisms, Dana-Farber Cancer Institute, Harvard Medical Spring Harbor, New York School, Boston, Massachusetts SPECTOR, MONA, Cold Spring Harbor Laboratory, Cold SERRANO, MANUEL, Centro Nacional de investigaciones Spring Harbor, New York Ontologica, Madrid, Spain STEWART, DAVID, Meetings and Courses Programs, Cold SHACHAF, CATHERINE, Dept. of Medical Oncology, Stan- Spring Harbor Laboratory, Cold Spring Harbor, New ford University, Stanford, California York SHERR, CHARLES, Dept. of Tumor Cell Biology, Howard STILLMAN, BRUCE, President and CEO, Cold Spring Har- Hughes Medical Institute, St. Jude Children’s Re- bor Laboratory, Cold Spring Harbor, New York search Hospital, Memphis, Tennessee SUH, KWANG, Lab. of Cellular Carcinogenesis and Tu- SHI, HUA, Dept. of Molecular Biology and Genetics, Cor- mor Promotion, National Cancer Institute, National In- nell University, Ithaca, New York stitutes of Health, Bethesda, Maryland SHIEH, SHEAU-YANN, Institute of Biomedical Sciences, SUKEZANE, TAIKO, Lab. of Molecular Oncology, Osaka Academia Sinica, Taipei, Taiwan, Republic of China Bioscience Institute, Osaka, Japan SHIH, HSIU-MING, Institute of Biomedical Sciences, SWAIN, AMANDA, Sect. of Gene Function and Regulation, Academia Sinica, Taipei, Taiwan, Republic of China Institute of Cancer Research, London, United Kingdom SHIMIZU, TAKESHI, Dept. of Biochemistry and Molecular SYMONS, MARC, Dept. of Oncology and Cell Biology, Biology, Pennsylvania State University, University North Shore-Long Island Jewish Institute for Medical Park, Pennsylvania Research, Manhasset, New York SHUKLA, NEERAV, Dept. of Pediatrics, Memorial Sloan- SÜLTMANN, HOLGER, Dept. of Molecular Genome Analy- Kettering Cancer Center, New York, New York sis, German Cancer Research Center, Heidelberg, Ger- SHUREIQI, IMAD, Dept. of Clinical Cancer Prevention, many M.D. Anderson Cancer Center, University of Texas, TANAKA, HISASHI, Div. of Basic Sciences, Fred Hutchin- Houston son Cancer Research Center, Seattle, Washington SIBSON, DAVID, J.K. Douglas Laboratories, Clatterbridge TARABAN, VADIM, Tenovus Research Laboratory, Uni- Cancer Research Trust, Clatterbridge Hospital, versity of Southampton, Southampton, United King- Bebington, Wirral, United Kingdom dom SIDENIUS, NICOLAI, Dept. of Transcriptional Mecha- TELERMAN, ADAM, Dept. of Cancer Research, Molecular nisms, FIRC Institute of Molecular Oncology Founda- Engines Laboratories, Paris, France tion, Milan, Italy TERAI, KENTA, Dept. of Tumor Virology, Research Insti- SILVA, RICARDO, Dept. of Hematology and Oncology, St. tute for Microbial Diseases, Osaka University, Osaka, Jude Children’s Research Hospital, Memphis, Ten- Japan nessee TERZIAN, TAMARA, Dept. of Molecular Genetics, Sect. of SILVESTRE, DAVID, Dept. of Biological Chemistry, Cancer Genetics, M.D. Anderson Cancer Center, Uni- CIQUIBIC, National University of Córdoba, Córdoba, versity of Texas, Houston Argentina TESSIER-LAVIGNE, MARC, Dept. of Research, Genentech, SIMIN, KARL, Dept. of Genetics, Lineberger Comprehen- Inc., South San Francisco, California sive Cancer Center, University of North Carolina, TEWS, BJOERN, Dept. of Molecular Genetics, German Chapel Hill Cancer Research Center, Heidelberg, Germany SLACK, FRANK, Dept. of Molecular, Cellular, and Devel- THEILLET, CHARLES, Genotypes et Phenotypes Tu- opmental Biology, Yale University, New Haven, Con- moraux, INSERM, Montpellier, France necticut THIAGALINGAM, SAM, Dept. of Medicine and Genetics, SLAMON, DENNIS, Dept. of Medicine, Hematology and Boston University School of Medicine, Boston, Mas- Oncology, University of California, Los Angeles sachusetts SLATE, DORIS, Dept. of Scientific Licensing, Johnson and THOMPSON, CRAIG, Abramson Family Cancer Research Johnson Pharmaceutical Research and Development, Institute, University of Pennsylvania, Philadelphia San Diego, California THUERIGEN, DIRK, Div. of Molecular Genetics, German SLIWKOWSKI, MARK, Dept. of Translational Oncology, Cancer Research Center, Heidelberg, Germany Genentech, Inc., South San Francisco, California TLSTY, THEA, Dept. of Pathology, School of Medicine, SMALL, MICHAEL, Div. of Extramural Research, National University of California, San Francisco Cancer Institute, National Institutes of Health, TRABONI, CINZIA, Dept. of Biochemistry, Institute for Re- Bethesda, Maryland search in Molecular Biology, Pomezia, Italy SMIRNOV, DENIS, Dept. of Research and Development, TREANOR, LOUISE, Dept. of Pathology, Unversity of Ed- Immunicon Corp., Huntingdon Valley, Pennsylvania inburgh, Edinburgh, Scotland, United Kingdom SOENGAS, MARIA, Dept. of Dermatology, University of TSAI, HSIN-YUE, Dept. of Biochemistry, Ohio State Uni- Michigan, Ann Arbor versity, Columbus, Ohio SONG, YURONG, Dept. of Genetics, Lineberger Compre- TSE, ARCHIE, Dept. of Medicine, Memorial Sloan-Ketter- hensive Cancer Center, University of North Carolina, ing Cancer Cancer, New York, New York Chapel Hill TSUCHIHASHI, ZENTA, Dept. of Pharmacogenomics, Bris- SPARMANN, ANKE, Dept. of Molecular Genetics, The tol-Myers Squibb, Princeton, New Jersey 00_Symp70_frontmatter 5/22/06 12:11 PM Page xiv

xiv SYMPOSIUM PARTICIPANTS

TSUCHIYA, NAOTO, Dept. of Biochemistry, National Can- WILKINSON, JOHN, Unit for Laboratory Animal Medicine, cer Center Research Institute, Tokyo, Japan University of Michigan, Ann Arbor TUVESON, DAVID, Dept. of Hematology and Oncology, WINTER, CHRISTOPHER, Dept. of Target Support and Val- Abramson Family Cancer Research Institute, Univer- idation, Merck Research Laboratories, Boston, Mas- sity of Pennsylvania, Philadelphia sachusetts UREN, ANTHONY, Dept. of Molecular Genetics, The WITTE, OWEN, Howard Hughes Medical Institute, Insti- Netherlands Cancer Institute, Amsterdam, The Nether- tute for Stem Cell Biology and Medicine, University of lands California, Los Angeles UZIEL, TAMAR, Dept. of Tumor Cell Biology, St. Jude WONG, SUNNY, Dept. of Biology, Massachusetts Institute Children’s Research Hospital, Memphis, Tennessee of Technology, Cambridge, Massachusetts VAFAI, SCOTT, Dept. of Cancer Biology, Dana-Farber WORKMAN, PAUL, Dept. of Cancer Therapeutics, Institute Cancer Institute, Boston, Massachusetts of Cancer Research, Sutton, Surrey, United Kingdom VAN DYCK, FREDERIK, Dept. of Human Genetics, Lab. for XIA, MINGXUAN, Dept. of Biomedical Genetics, University Molecular Oncology, University of Leuven, Leuven, of Rochester Medical Center, Rochester, New York Belgium XIONG, YUE, Dept. of Biochemistry and Biophysics, Uni- VAN DYKE, TERRY, Dept. of Biochemistry, University of versity of North Carolina, Chapel Hill North Carolina, Chapel Hill XU, JUN, Dept. of Oncology Research, Wyeth, Pearl VAN LOHUIZEN, MAARTEN, Dept. of Moleular Genetics, River, New York The Netherlands Cancer Institute, Amsterdam, The XU, LEI, Center for Cancer Research, Massachusetts In- Netherlands stitute of Technology, Cambridge, Massachusetts VARMUS, HAROLD, President and CEO, Memorial Sloan- XU, QING, Dept. of Medical Oncology, Dana-Farber Can- Kettering Cancer Center, New York, New York cer Institute, Boston, Massachusetts VENKATARAMAN, CHANDRASEKAR, Dept. of Cancer Re- XU, RUI-MING, Cold Spring Harbor Laboratory, Cold search, Eli Lilly and Company, Indianapolis, Indiana Spring Harbor, New York VIGNERON, ARNAUD, Cancer Center Paul Papin, XU, XINGZHI, Dept. of Biology, Beckman Research Insti- INSERM, Angers, France tute, City of Hope Medical Center, Duarte, California VILENCHIK, MARIA, Dept. of Oncology, Hoffmann-La YAMACI, REZAN, Dept. of Molecular Biology and Genet- Roche, Inc., Nutley, New Jersey ics, Bogazici University, Istanbul, Turkey VILLANUEVA, JESSIE, Dept. of Pharmacology, University YAMADA, N. ALICE, Dept. of Biosciences, Lawrence Liv- of Pennsylvania, Philadelphia ermore National Laboratory, Livermore, California VINCENT, SYLVIE, Dept. of Molecular Technology, YAMASAKI, LILI, Dept. of Biological Sciences, Columbia AVEO Pharmaceuticals, Cambridge, Massachusetts University, New York, New York VINSON, CHARLES, Lab. of Metabolism, National Insti- YANCOPOULOS, GEORGE, Regeneron Pharmaceuticals, tutes of Health, Bethesda, Maryland Inc., Tarrytown, New York VREDEVELD, LIESBETH, Dept. of Molecular Genetics, The YANG, QUAN, Dept. of Therapeutics, IBEX Pharmaceuti- Netherlands Cancer Institute, Amsterdam, The Nether- cals, Inc.,Montréal, Québec, Canada lands YARDEN, RONIT, Dept. of Surgical Oncology, Chaim WALLACE, DOUGLAS, Center for Molecular and Mito- Sheba Medical Center, Tel-Hashomer, Israel chondrial Medicine and Genetics, University of Cali- YIM, SUN HEE, Lab. of Metabolism, National Cancer Insti- fornia, Irvine tute, National Institutes of Health, Bethesda, Maryland WANG, GREG, Biomedical Sciences Program, School of YOON, SUNG OK, Dept. of Cellular Immunology, Ochsner Medicine, University of California at San Diego, La Jolla Clinic Foundation, Jefferson, Louisiana WANG, LIANG, Cold Spring Harbor Laboratory, Cold ZENDER, LARS, Cold Spring Harbor Laboratory, Cold Spring Harbor, New York Spring Harbor, New York WATNICK, RANDOLPH, Dept. of Surgery, Children’s Hos- ZHANG, HONGBING, Dept. of Hematology, Brigham and pital, Harvard Medical School, Boston, Massachusetts Women’s Hospital, Harvard Medical School, Boston, WEI, GANG, Dept. of Tumorigenesis, Lankenau Institute Massachusetts for Medical Research, Wynnewood, Pennsylvania ZHANG, QIAN, Dept. of Genetics, Biochemistry, and Bio- WEINMANN, ROBERTO, Dept. of Oncology Drug Discov- physics, Lineberger Comprehensive Cancer Center, ery, Bristol-Myers Squibb, Princeton, New Jersey University of North Carolina, Chapel Hill WEINREICH, MICHAEL, Van Andel Research Institute, ZHANG, XIAOSHAN, Dept. of Molecular Genetics, M.D. Grand Rapids, Michigan Anderson Cancer Center, University of Texas, Houston WEISSMAN, SHERMAN, Dept. of Genetics, Yale University ZHANG, YANPING, Dept. of Radiation Oncology, Univer- School of Medicine, New Haven, Connecticut sity of North Carolina, Chapel Hill WENDEL, HANS-GUIDO, Cold Spring Harbor Laboratory, ZHOU, ZONGXIANG, Dept. of Biomedical Sciences, Cor- Cold Spring Harbor, New York nell University, Ithaca, New York WERB, ZENA, Dept. of Anatomy, University of Califor- VAN DER MEIJDEN, CAROLINE, Cold Spring Harbor Labo- nia, San Francisco ratory, Cold Spring Harbor, New York WESTBROOK, TREY, Dept. of Genetics, Harvard Univer- VAN DE WETERING, ChRISTOPHER, Dept. of Pathology, sity School of Medicine, Boston, Massachusetts University of Iowa Hospitals and Clinics, Iowa City 00_Symp70_frontmatter 5/22/06 12:11 PM Page xv

First row: Craig Thompson delivering eulogy for Stanley Korsmeyer (on screen, S. Korsmeyer [l] and M. Hengartner [r]) Second row: R. Eisenman, C. Thompson, and J. Adams; Z. Werb; J. Kan, G. Borzilllo Third row: P. Kenny, M. Bissell, M. Godbole; J. Inglis, J. Allison 00_Symp70_frontmatter 5/22/06 12:11 PM Page xvi

First row: L. Schweizer, R. Scotillo, M. Jechlinger; J.D. Watson, S. Brenner Second row: R. Bernards, T. de Lange; B. Alberts, E. Harlow, H. Varmus; S. Lowe, S. Elledge Third row: Watching Symposium in Grace lobby; G. Gupta, P. Gupta, R. Saplis Fourth row: G. Enikolopov, R. Attar; T. Tlsty; Y. Song, S.O. Yoon, J. Villanueva 00_Symp70_frontmatter 5/22/06 12:11 PM Page xvii

First row: B. Luscher, S. Rottmann; C. Schubert, K. Quon, G. Peters, C. Martins, M. Fero Second row: E. Harlow, D. Esposito; Under the tent Third row: C. Miranti, S. Wong, E. Medico; A. Fournier, H.-G. Kang, I. Sansal Fourth row: P. Coopman, R. Yarden; M. Barbacid, S. Courtneidge 00_Symp70_frontmatter 5/22/06 12:11 PM Page xviii

First row: G. MacDonald, S. Benvenuti, J. Saunus, K. Chan; C. Shachaf, O. Margalit, G. Rechavi, N. Amariglio Second row: J. Lees, G. Evan, C. Sherr; J. Bargonetti, H. Ozer; M. Kastan, J. Lees, T. Van Dyke Third row: C. Greider, R. DePinho; J.D. Watson, M. Tessier-Lavigne; J. Folkman Fourth row: Cancer Genome Project Discussion Panel (l–r) E. Lander, S. Brenner, H. Varmus, B. Alberts, J. Brugge, J. Peterson, A. Barker; C. Prives 00_Symp70_frontmatter 5/22/06 12:11 PM Page xix

First row: L. Attardi; K. Hillan, D. Stewart, sporting the Symposium T-shirt; D. Wallace; M. Bishop Second row: M. Eilers, M. Van Lohuizen; A. Gradi, N. Sacchi Third row: H.-G. Wendell, B. Clarkson; J. Massagué, B. Stillman, R. Benezra Fourth row: C. Andl, D. Thuerigen; M. Hickey, K. Olive, K. Covello, M. Gruber 00_Symp70_frontmatter 5/22/06 12:11 PM Page xx

First row: H. Rauhala, O. Saramaki; N. Sacchi, L. Parada Second row: A. Ballesteros, A. Ashworth; B. Marte, G. Hannon; E. Lander Third row: B. Tews, M. Hahn, D. Spector; Posters under the tent Fourth row: D. Lane; R. Kalluri; M. Meyerson, D. Haber, M. Ladanyi 00_Symp70_frontmatter 5/22/06 12:11 PM Page xxi

First row: G. Poortinga, C. Billottet, A. Majid; C. Scott, S. Smith Second row: R. Kalluri, M. Tessier-Lavigne, D. Hanahan; A. Majid, M. Junttila Third row: C. Abate-Shen, A. Cheung, K. Lane; C. Sawyers, Dorcas Cummings Lecture; F. McCormick; T. Jacks giving Summary Fourth row: Symposium picnic 00_Symp70_frontmatter 5/22/06 12:11 PM Page xxii 00_Symp70_frontmatter 5/22/06 12:11 PM Page xxiii

Dedication

Stan Korsmeyer passed away on March 31, 2005, at the age of 54. Ironically, he died of lung cancer. He had been looking forward to attending this meeting focused on molecular approaches to controlling cancer, a subject he dedicated his life to. Despite being gravely ill, he registered for the meeting. In the meeting book, he is listed as one of the participants and, in spirit, he was. Stan grew up on a hog farm in southern Illinois. He did not start out to be a research scientist. In college, he became interested in science and decided to go to medical school. He went through internship and residency at the University of California, San Francisco, followed by a fellowship at the NIH. He arrived in Bethesda at the time when physi- cians were first learning molecular biology and applying it to cancer research. In those days, the cancer research meeting was the Cold Spring Harbor Symposium on Viral Oncogenes. It was through the scientific exchange at that Stanley J. Korsmeyer meeting that Stan and others in the community came to re- 1950–2005 alize that chromosomal translocations might represent oncogenic events that could be molecu- larly characterized. Stan started working on this problem as a postdoctoral fellow in the laboratories of Phil Leder and Tom Waldman. Armed with that training, he joined the faculty at Washington University in St. Louis as an assistant professor. Stan did not start out as a central figure in the outstanding hematology and oncology faculty assembled there by Stuart Kornfield. Stan stood at the edge of that group, bridging it to molecular biology. However, even then, Stan was quickly moving to the center of our community. By characterizing chromosomal translocations, Stan’s laboratory was one of the groups that cloned the oncogenes Bcl-2 and MLL. By the time of the 1994 CSHL Symposium on Cancer, Stan’s work led many of us to consider the role of apoptosis in cancer. That was the first meeting where we started to discuss whether the regulation of programmed cell death played a critical role in the pathogenesis of cancer. Stan believed understanding apoptosis might contribute to new therapies for cancer. Stan’s work over the next few years brought him to the leading edge of biology. His ground- breaking work defining the Bcl-2 family members as interactive partners controlling the rheostat of apoptosis moved him to center stage. In 1998, Stan was recruited to Harvard University to nu- cleate a research program in apoptosis. With his positive and interactive personality, he quickly became a leader at the Dana-Farber Cancer Center. At every scientific meeting, Stan was the one asking the probing questions and suggesting col- laborations that would lead to the answers to those questions. Stan had that unique capability of organizing people, focusing them on the activity at hand, and, even though they’d never done it before, giving them the skills to go out and do research on the murky waters of cancer biology. In closing, we remember him as a friend, colleague, and a real leader in this community, and for the positive interactions that he spurred within the cancer biology community. It is in that spirit that CSHL dedicates this volume to his memory.

Craig B. Thompson

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Foreword

During the past quarter century or so, much effort has been devoted toward the understanding of the molecular basis of cancer. We now understand that cancer is primarily a genetic disease of mutations in the tumor genome acquired over a lifetime. The products of oncogenes and tumor suppressor genes have been placed into pathways of gene networks that are altered in tumor cells compared to normal cells in tissue. Furthermore, we also understand that tumors function as abnormal organs, forming an architecture of a number of different cell types and recruiting a blood supply, albeit an irregular one. There have been many Symposia in this series that dealt with cancer directly, and even more that focused on basic biology that contributed greatly to understanding cancer. As a result of some interesting developments in cancer diagnosis and therapy over the past five years, it was appropriate that a Symposium be devoted for the first time to molecular approaches to cancer therapy. Several examples now exist of targeted therapy that works in patients that have been profiled based on genetic diagnosis of the patient’s tumor. Additionally, therapies targeting the tumor as an organ, such as anti-angiogenic therapy, are now used in the clinic with modest success. The hope is that this type of molecular approach to cancer therapy will accelerate and become more effective in the future. In organizing this Symposium with help from Terri Grodzicker, we relied on the assistance of a number of colleagues for suggestions for speakers. They included David Livingston, Craig Thompson, and Scott Lowe, and we thank them for their valuable advice. We also thank the first evening speakers, Dennis Slamon, Harold Varmus, Mina Bissell, and Jim Allison, for providing an overview of the areas to be covered. This year’s Reginald Harris Lecture was delivered by Titia de Lange on telomere biology and genomic stability. We particularly thank Tyler Jacks for delivering a thoughtful and realistic summary of where we are in relation to our goal. Charles Sawyers, who conveyed the excitement which many of us feel knowing that some inroads into treating cancer will be made by targeted therapies, presented the Dorcas Cummings Lecture to the local community and the attending scientists. The effort put into the Dorcas Cummings Lec- ture by Charles and the summary by Tyler resulted in highlights of the meeting. This Symposium was attended by 515 scientists and clinicians, and the program included 71 oral presentations and 241 poster presentations. Bruce Alberts chaired a discussion of the pro- posal to analyze the genomes of all major human cancers to advance cancer diagnosis and therapy approaches. Essential funds to run this meeting were obtained from the National Cancer Institute, a branch of the National Institutes of Health. In addition, financial help from the corporate benefactors, sponsors, affiliates, and contributors of our meetings program is essential for these Symposia to remain a success, and we are most grateful for their continued support. We thank Val Pakaluk and Mary Smith in the Meetings and Courses office for their efficient help in organizing the Symposium. Joan Ebert, Patricia Barker, and Susan Schaefer in the Cold Spring Harbor Laboratory Press, headed by John Inglis, ensured that this volume would be pro- duced. We thank them for their dedication to producing high-quality publications.

Bruce Stillman David Stewart April 2006

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