The David Rockefeller Graduate Program 2011-2012 the David Rockefeller Graduate Program 2011-2012

Total Page:16

File Type:pdf, Size:1020Kb

The David Rockefeller Graduate Program 2011-2012 the David Rockefeller Graduate Program 2011-2012 THE DAVID ROCKEFELLER GR ADUATE PROGR AM 2011-2012 Published by The Rockefeller University Office of Communications and Public Affairs The david rockefeller graduate program 2011-2012 PRESIDENT’S MESSAGE 2 DEAN’S MESSAGE 5 ACADEMIC PROgrams 6 RESEARCH Areas 12 FACILITIES 17 STUdent LIFE 20 AdmissiONS AND SCHEDULE OF COUrses 25 LIFE AFTER ROCKEFELLER 30 PRESIDENT’S MESSAGE “For MORE THAN A CENTURY, THE ROCKEFELLER UNIVERSITY HAS FUL- FILLED THE MISSION MY GRANDFATHER HAD ENVISIONED, TO PRODUCE DISCOVERIES THAT WOULD BENEFIT HUMANKIND. IT HAS BECOME ONE OF THE world’s GREAT MEDICAL RESEARCH INSTITUTions.” DAVID ROCKEFELLER, LIFE TRUSTEE For me, neuroscience was love at first sight. Understanding the brain and wanting to know how to deconstruct and resolve its complexity fueled my career initially and still motivates me in my lab today. People fall in love with science at differ- ent times in their lives and bring their own perspective to learning and doing science, but the common denominator is an excitement and curiosity to understand the world around them — that’s what The Rockefeller University’s graduate pro- gram is designed to nurture. It is also what fuels Rockefeller’s world-class faculty, who push the boundaries of knowledge with their innovative approaches to scientific discovery. In an environment without departments that supports freedom to explore different areas of science, both students and faculty chart their own paths. For faculty, it enables research that has led to pioneering discoveries with the potential to erad- icate disease and reduce suffering for millions. For students, it provides flexibility to work with more than one professor on their chosen thesis topic. For both, it enables collaboration and interdisciplinary research, which are the university’s hallmark. Rockefeller is truly unique, as it exists solely to support science; thus, every aspect of the administration is dedicated to the success of our scientists. In fact, every member of our scientific administration is an active faculty member, with an active lab. Vital to the success of the faculty and students in these labs are modern and well-equipped buildings, an infra- structure that has been further strengthened by the recent opening of the Collaborative Research Center, which promotes interactions between scientists in modern lab spaces and open areas. We’re also well served by scientific resource centers that provide state-of-the-art research support services. At Rockefeller, we believe students should learn science by doing science, shoulder to shoulder with some of the world’s leading researchers, who guide and mentor them every step of the way. We care about the learning and progress of every student and want to ensure that each and every experience at Rockefeller is maximized. As a student at Rockefeller, you’ll be part of a diverse and supportive community that is a haven for creative, independent thinkers. Your time will be spent on an extraordinary campus, a green oasis nestled in one of the most exciting cities in the world. Deciding where to pursue your graduate training is not easy, as there are many outstanding institutions from which to choose. However, Rockefeller stands out among its peers, providing developing scientists an unparalleled educational experience. We hope you’ll join us. Marc Tessier-Lavigne President 2 | THE ROCKEFELLER UNIVERSITY THE DAVID ROCKEFELLER GRADUATE PROGRAM 20 11–20 1 2 | 3 4 | THE ROCKEFELLER UNIVERSITY Dean’S MESSAGE “AT ROCKEFELLER, CURIOSITY IS CELEBRATED IN A WAY THAT IS VIRTUALLY UNEQUALED IN THE ACADEMIC UNIVERSE. OUR FACULTY ASK QUESTIONS THAT ARE PUSHING THE VERY BOUNDARIES OF HUMAN KNOWLEDGE. OUR STUDENTS ARE AT THE CENTER OF THIS RESEARCH ENTerprise.” PAUL NURSE, PRESIDENT EMERITUS Rockefeller has a graduate program unlike any in the world. Since its beginning more than 50 years ago, five principles have guided the program: Recruit the best students, regardless of citizenship. International diversity is both intellectually and culturally stimulating. Our global approach is possible because we have significant private support for our students. Our current student popula- tion consists of approximately 200 students from 32 countries. Provide a flexible academic program. Students are all different and have diverse interests and needs. We support indi- vidual development by giving our students the freedom to design their own curricula. They fulfill credit requirements with courses of interest and have the option to conduct several rotations or immediately affiliate with a lab. Provide generous professional and personal support. Relieving worries about practical matters allows our students more time to be creative with their scientific pursuits. They receive a yearly stipend, free health and dental insurance, highly subsidized housing on or near campus and an annual research allowance for travel and lab support. Strongly encourage interactions. Students are often the catalyst for collaborations between labs, and some of the most revolutionary ideas span disciplines. To foster interactions, we have an annual student retreat organized and run by stu- dents, numerous scientific lecture series where students interact with speakers from around the world and a series with speakers from the arts and humanities to provide alternative perspectives. Ensure careful mentoring throughout the graduate career. The freedom of our graduate program requires supportive advice and mentoring. In the first year, counsel is provided by the Dean’s Office, and in later years, by the research adviser and a faculty committee. The program has been an extraordinary success. Of more than 1,000 graduates, two have won the Nobel Prize, 26 are members of the United States National Academy of Sciences and our alumni occupy influential positions in academia, industry and many other fields. Graduate school is an important step in becoming a professional scientist. Although it has a well-defined end point — the Ph.D. degree — it really is just a beginning. All of the things that go into becoming a scientist — learning new ideas, perfect- ing new experimental techniques, refining analytical abilities — are lifelong endeavors. Our goal at Rockefeller is to equip you with both the skills and the self-confidence to begin your journey. Sidney Strickland Dean THE DAVID ROCKEFELLER GRADUATE PROGRAM 20 11–20 1 2 | 5 ACADEMIC PROGRAMS “THERE ARE MANY REASONS THAT THE ROCKEFELLER UNIVERSITY IS SPECIAL. IT’s WONDERFULLY SMALL AND THAT MEANS NO ONE GETS LOST. THE HOPE IS ALWAYS THAT SOME VERY IMPORTANT SCIENCE CAN OCCUR THAT MIGHT NOT EVER HAPPEN OTherwise.” MICHAEL W. YOUNG, VICE PRESIDENT FOR ACADEMIC AFFAIRS For over 100 years, biomedical science has been The Rockefeller University’s singular priority. Founded in 1901 by John D. Rockefeller as The Rockefeller Institute for Medical Research, it was the first institution in the United States devoted solely to understanding the causes of disease. Today, renamed The Rockefeller University, it is one of the foremost research centers in the world, with a world-class faculty including six Nobel Prize laureates and 37 members or foreign associates of the National Academy of Sciences. The graduate program admitted its first students in 1955, and since then more than 1,000 scientists have received degrees from Rockefeller. As a Rockefeller graduate student, you will be part of a diverse community of over 2,000, including students, postdocs, faculty and administrative staff. Though Rockefeller is a small school, our location adjacent to Weill Cornell Medical College, NewYork-Presbyterian Hospital and Memorial Sloan-Kettering Cancer Center puts us at an epicenter of scientific activity. Our students truly have the best of both worlds: a personal, highly flexible training program and access to a broad range of collaborators and resources. PH.D. Program Rockefeller’s Ph.D. program is based on the concept of learning science by doing science, and our laboratories are at the center of the Ph.D. training program. There are 74 laboratories at Rockefeller, each headed by a tenured or tenure-track member of the faculty, that study a wide range of biomedical and related sciences, including biochemistry, structural biology and chemistry; medical sciences and human genetics; molecular, cell and developmental biology; immunology, virology and microbiology; neuroscience; and physics and mathematical biology. Students who arrive with a particular mentor or project in mind may immediately join a laboratory; those who prefer to explore may rotate through several laboratories to gain exposure to different areas of research. Students choose a labora- tory by the end of their first year and present a thesis proposal before the end of their second year. The collegial nature of the laboratory environment links younger students to previous generations from the same lab, as well as to postdocs and faculty mentors. The collaborations that result from these relationships are not only the basis on which our scientific education is built, they are the engine that drives the discovery process. Many collaborations pro- duce exceptional results that lead to publication in prominent journals. And the relationships formed within laboratories often lead to lifelong associations. While formal coursework is minimal, several classes each semester offer foundations in particular specialties, and three required courses taken during the first year serve to develop students’ abilities to critically interpret scientific data, to 6 |
Recommended publications
  • Looking at Earth: an Astronaut's Journey Induction Ceremony 2017
    american academy of arts & sciences winter 2018 www.amacad.org Bulletin vol. lxxi, no. 2 Induction Ceremony 2017 Class Speakers: Jane Mayer, Ursula Burns, James P. Allison, Heather K. Gerken, and Gerald Chan Annual David M. Rubenstein Lecture Looking at Earth: An Astronaut’s Journey David M. Rubenstein and Kathryn D. Sullivan ALSO: How Are Humans Different from Other Great Apes?–Ajit Varki, Pascal Gagneux, and Fred H. Gage Advancing Higher Education in America–Monica Lozano, Robert J. Birgeneau, Bob Jacobsen, and Michael S. McPherson Redistricting and Representation–Patti B. Saris, Gary King, Jamal Greene, and Moon Duchin noteworthy Select Prizes and Andrea Bertozzi (University of James R. Downing (St. Jude Chil- Barbara Grosz (Harvard Univer- California, Los Angeles) was se- dren’s Research Hospital) was sity) is the recipient of the Life- Awards to Members lected as a 2017 Simons Investi- awarded the 2017 E. Donnall time Achievement Award of the gator by the Simons Foundation. Thomas Lecture and Prize by the Association for Computational American Society of Hematology. Linguistics. Nobel Prize in Chemistry, Clara D. Bloomfield (Ohio State 2017 University) is the recipient of the Carol Dweck (Stanford Univer- Christopher Hacon (University 2017 Robert A. Kyle Award for sity) was awarded the inaugural of Utah) was awarded the Break- Joachim Frank (Columbia Univer- Outstanding Clinician-Scientist, Yidan Prize. through Prize in Mathematics. sity) presented by the Mayo Clinic Di- vision of Hematology. Felton Earls (Harvard Univer- Naomi Halas (Rice University) sity) is the recipient of the 2018 was awarded the 2018 Julius Ed- Nobel Prize in Economic Emmanuel J.
    [Show full text]
  • 2011 Annual Report
    Memorial Sloan-Kettering Cancer Center 2011 Annual Report 10 steps closer 10 steps closer Letter from the Chairman and the President 1 1 | First effective treatments for advanced melanoma 5 2 Genomic analysis offers clues to most common | type of ovarian cancer 7 3 Breast cancer surgery: practice-changing | findings for some patients 9 4 New drugs offer survival benefit for men | with metastatic prostate cancer 11 5 | Insights into DNA damage and repair 13 6 Novel stem cell technique shows promise | in treating disease 15 7 Combination therapy may prevent spread | of nasopharyngeal tumors 17 8 Algorithm can predict shape of proteins, | speeding basic cancer research 19 9 Two of 2011’s top five advances in cancer | research led by MSKCC physician-scientists 21 10 | The Josie Robertson Surgery Center 23 The Campaign for Memorial Sloan-Kettering 25 Statistical Profile 27 Financial Summary 29 Boards of Overseers and Managers 31 www.mskcc.org/annualreport Letter from the Chairman and the President The year 2011 was a strong one at Memorial Sloan-Kettering. We continued to lead across “Our success as an institution is due in the spectrum of patient care, research, and training, and laid the groundwork for important progress in the years ahead. great measure to our remarkable staff… We want to begin by saying that our success as an institution is due in great measure to our remarkable staff. On a daily basis, we are inspired by their dedication and compassion, and We are inspired by their dedication Douglas A. Warner III are grateful for the work they do in the service of our patients and our mission.
    [Show full text]
  • Faster Growth with Shorter Antigens Explains a VSG Hierarchy During African Trypanosome Infections: a Feint Attack by Parasites
    bioRxiv preprint doi: https://doi.org/10.1101/131029; this version posted April 26, 2017. The copyright holder for this preprint (which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under aCC-BY-NC-ND 4.0 International license. Faster growth with shorter antigens explains a VSG hierarchy during African trypanosome infections: a feint attack by parasites Dianbo Liu1, Luca Albergante1,2, David Horn1,*, Timothy Newman1,* 1School of Life Sciences, University of Dundee, Dundee, UK 2U900, Institut Curie, 75005, France *These authors contributed equally Correspondence to [email protected] and [email protected] Abstract The parasitic African trypanosome, Trypanosoma brucei, evades the adaptive host immune response by a process of antigenic variation that involves the clonal switching of variant surface glycoproteins (VSGs). The VSGs that periodically come to dominate in vivo display a hierarchy, but how this hierarchy arises is not well-understood. Combining publicly available genetic data with mathematical modelling, we report a VSG-length-dependent hierarchical timing of clonal VSG dominance in a mouse model, revealing an inverse correlation between VSG length and trypanosome growth-rate. Our analysis indicates that, among parasites switching to new VSGs, those expressing shorter VSGs preferentially accumulate to a detectable level that is sufficient to trigger an effective immune response. Subsequent elimination of faster-growing parasites then allows slower parasites with longer VSGs to accumulate. This interaction between the host and parasite is able by itself to explain the temporal distribution of VSGs observed in vivo.
    [Show full text]
  • Resubmission JBC Frescas and De Lange
    Cell Biology: Binding of TPP1 Protein to TIN2 Protein Is Required for POT1a,b Protein-mediated Telomere Protection David Frescas and Titia de Lange J. Biol. Chem. 2014, 289:24180-24187. doi: 10.1074/jbc.M114.592592 originally published online July 23, 2014 Downloaded from Access the most updated version of this article at doi: 10.1074/jbc.M114.592592 http://www.jbc.org/ Find articles, minireviews, Reflections and Classics on similar topics on the JBC Affinity Sites. Alerts: • When this article is cited • When a correction for this article is posted at Rockefeller University Library on August 31, 2014 Click here to choose from all of JBC's e-mail alerts This article cites 29 references, 13 of which can be accessed free at http://www.jbc.org/content/289/35/24180.full.html#ref-list-1 THE JOURNAL OF BIOLOGICAL CHEMISTRY VOL. 289, NO. 35, pp. 24180–24187, August 29, 2014 © 2014 by The American Society for Biochemistry and Molecular Biology, Inc. Published in the U.S.A. Binding of TPP1 Protein to TIN2 Protein Is Required for POT1a,b Protein-mediated Telomere Protection* Received for publication, June 30, 2014, and in revised form, July 22, 2014 Published, JBC Papers in Press, July 23, 2014, DOI 10.1074/jbc.M114.592592 David Frescas and Titia de Lange1 From the Laboratory for Cell Biology and Genetics, The Rockefeller University, New York, New York 10065 Background: Chromosome ends require the TPP1/POT1 heterodimers for protection. Results: A TIN2 mutant that fails to bind TPP1 resulted in phenotypes associated with TPP1/POT1 deletion.
    [Show full text]
  • Analysis of Activation Induced Cytidine Deaminase Using Atomic Force Microscopy by C David J
    Analysis of Activation Induced Cytidine Deaminase using Atomic Force Microscopy by c David J. G. Gale A dissertation submitted to the School of Graduate Studies in partial fulfillment of the requirements for the degree of Master of Science Department of Chemistry Memorial University of Newfoundland April 2021 St. John’s Newfoundland Abstract Activation induced cytidine deaminase (AID) plays a large part within the pathway of immunoresponse. It does so by inserting mutations, during DNA replication, in B cells (immune system cells). This results in a more diverse set of antibodies in each subsequent generation. However, mutations that cause infinite replication with no cellular apoptosis, can lead to cancer. AID has been implicated in cancers which appear independent of the expected environmental causes, such as smoking or UV exposure. The method for AID mutations involves binding to single-strand DNA. Using Atomic Force Microscopy (AFM) we obtained both the geometry or topology, as well as the nanomechanical information about this mutation process and AID. In this thesis, I present the first AFM images of AID, showing direct structural information about the protein. Although the measurements are done in vitro, physiological con- ditions have been approximated in order to get an accurate analysis of the protein system. To allow imaging in buffer, suitable substrates were tested and identified which would bind the protein sufficiently in this high ionic strength environment. Optimized plating and scan conditions for AID in both wet and dry conditions are described, which allow high resolution imaging to be performed that is not often seen in biological systems. Through the many scans and procedural changes it was estab- lished that although difficult it is possible to gain an image of AID through the use ii of AFM.
    [Show full text]
  • Schedule of C Ourses
    2020–2021 Schedule of Courses Schedule The David Rockefeller Graduate Program offers a multiple sclerosis); perception, cognition, and memory (autism, schizophrenia, and Alzheimer’s disease); consciousness (coma selection of courses, many of which students can and persistent vegetative state); mood (depression and anxiety); choose based on their interests and area of thesis motivation (addiction); sensation (pain); motor control (Parkinson’s research. Organized by Rockefeller faculty, and taught disease and ataxia); and trauma (brain or spinal cord injury and stroke). by scientists at the top of their fields, both from within Class length and frequency: Two-hour session, once weekly and outside of the university, these courses provide a Method of evaluation: Attendance, participation in the discussions, stimulating and dynamic curriculum that students can student presentations, and a final speculative paper relating a tailor to fit their personal goals, in consultation with disordered trait to a specific brain circuit the dean of graduate studies. Cell Biology SANFORD M. SIMON and SHAI SHAHAM Biochemical and Biophysical Methods, I & II This advanced course covering major topics in modern cell biology is GREGORY M. ALUSHIN, SETH A. DARST, SHIXIN LIU, and MICHAEL P. ROUT taught by faculty and visitors who are specialists in various disciplines. This course presents the fundamental principles of biochemistry Class length and frequency: Three-hour lecture, once weekly; and biophysics, with an emphasis on methodologies. In addition, two-hour discussion, twice weekly case studies are discussed, examining how physical and chemical methods have been used to establish the molecular mechanisms Prerequisite(s): Good knowledge of textbook cell biology of fundamental biological processes.
    [Show full text]
  • 2020– 2024 Strategic Plan
    2020-2024 STRATEGIC PLAN Amy Shyer, head of the Laboratory of Morphogenesis, studies the mechanical forces and molecular A new plan is intended to cues that guide tissue formation maximize the university’s in a developing embryo. She was scientific impact over the recruited to Rockefeller in 2018. next five years A five-year strategic plan for the university, developed in 2019, sets Investing in the most audacious and a course for new investments in faculty recruitment, technological original scientists in the world acquisitions, translational efforts, and other priorities between 2020 and 2024. The plan, titled “The Convergence of Science and Medicine,” The plan calls for maintaining the open-search process that has was approved by the Board of Trustees at its November 6 meeting. driven tenure-track faculty recruitment over the past decade. A The plan’s development was overseen by President Richard P. Lifton, second key goal is the appointment of new mid-career faculty in two who led a committee of faculty members and administrators through areas: computational biology and neurodegenerative disease. The a review of Rockefeller’s strengths, operations, and aspirations. The pace of hiring will be consistent with past practice: one to two new convergence of basic science, clinical medicine, and therapeutic heads of laboratory per year, maintaining the number of heads of discovery has set the stage for exceptional advances, says Lifton, laboratory at around 75. The plan also underscores the university’s and the plan will build on the technological breakthroughs of the last continued commitment to the recruitment of exceptional graduate decade to lead a new revolution in the development of novel medicine.
    [Show full text]
  • A Model for Interclonal Competition in the Germinal Center: Dynamic Selection Processes By-Pass the Affinity Dead-End of Low Affinity Anti-NP Specific B Cells
    A model for interclonal competition in the germinal center: Dynamic selection processes by-pass the affinity dead-end of low affinity anti-NP specific B cells Der Naturwissenschaftlichen Fakultät der Friedrich-Alexander-Universität Erlangen-Nürnberg zur Erlangung des Doktorgrades Dr. rer nat. vorgelegt von Andreas Acs aus Timisoara Als Dissertation genehmigt von der Naturwissenschaftlichen Fakultät der Friedrich-Alexander-Universität Erlangen-Nürnberg Tag der mündlichen Prüfung: 15. Februar 2019 Vorsitzender des Promotionsorgans: Prof. Dr. Georg Kreimer Gutachter/in: Prof. Dr. Thomas Winkler PD Dr. rer. nat. Dr. habil. med. Dirk Mielenz Table of contents Table of contents 1 Zusammenfassung ............................................................................................................ 1 1 Summary ............................................................................................................................ 2 2 Introduction ....................................................................................................................... 3 2.1 B cell development ........................................................................................................ 3 2.1.1 Stages of B cell development are defined by recombination events of the B cell receptor in the bone marrow ........................................................................................... 3 2.12 GOD – Generation of diversity ................................................................................ 4 2.1.3 Migration of B
    [Show full text]
  • A High-Throughput Approach to Uncover Novel Roles of APOBEC2, a Functional Orphan of the AID/APOBEC Family
    Rockefeller University Digital Commons @ RU Student Theses and Dissertations 2018 A High-Throughput Approach to Uncover Novel Roles of APOBEC2, a Functional Orphan of the AID/APOBEC Family Linda Molla Follow this and additional works at: https://digitalcommons.rockefeller.edu/ student_theses_and_dissertations Part of the Life Sciences Commons A HIGH-THROUGHPUT APPROACH TO UNCOVER NOVEL ROLES OF APOBEC2, A FUNCTIONAL ORPHAN OF THE AID/APOBEC FAMILY A Thesis Presented to the Faculty of The Rockefeller University in Partial Fulfillment of the Requirements for the degree of Doctor of Philosophy by Linda Molla June 2018 © Copyright by Linda Molla 2018 A HIGH-THROUGHPUT APPROACH TO UNCOVER NOVEL ROLES OF APOBEC2, A FUNCTIONAL ORPHAN OF THE AID/APOBEC FAMILY Linda Molla, Ph.D. The Rockefeller University 2018 APOBEC2 is a member of the AID/APOBEC cytidine deaminase family of proteins. Unlike most of AID/APOBEC, however, APOBEC2’s function remains elusive. Previous research has implicated APOBEC2 in diverse organisms and cellular processes such as muscle biology (in Mus musculus), regeneration (in Danio rerio), and development (in Xenopus laevis). APOBEC2 has also been implicated in cancer. However the enzymatic activity, substrate or physiological target(s) of APOBEC2 are unknown. For this thesis, I have combined Next Generation Sequencing (NGS) techniques with state-of-the-art molecular biology to determine the physiological targets of APOBEC2. Using a cell culture muscle differentiation system, and RNA sequencing (RNA-Seq) by polyA capture, I demonstrated that unlike the AID/APOBEC family member APOBEC1, APOBEC2 is not an RNA editor. Using the same system combined with enhanced Reduced Representation Bisulfite Sequencing (eRRBS) analyses I showed that, unlike the AID/APOBEC family member AID, APOBEC2 does not act as a 5-methyl-C deaminase.
    [Show full text]
  • TELOMERE EXTENSION USING MODIFIED TERT Mrna TO
    TELOMERE EXTENSION USING MODIFIED TERT mRNA TO LENGTHEN HEALTHSPAN A DISSERTATION SUBMITTED TO THE NEUROSCIENCES PROGRAM AND THE COMMITTEE ON GRADUATE STUDIES OF STANFORD UNIVERSITY IN PARTIAL FULFILLMENT OF THE REQUIREMENTS FOR THE DEGREE OF DOCTOR OF PHILOSOPHY John Ramunas May 2014 © 2014 by John Ramunas. All Rights Reserved. Re-distributed by Stanford University under license with the author. This work is licensed under a Creative Commons Attribution- Noncommercial 3.0 United States License. http://creativecommons.org/licenses/by-nc/3.0/us/ This dissertation is online at: http://purl.stanford.edu/vb798wq6556 ii I certify that I have read this dissertation and that, in my opinion, it is fully adequate in scope and quality as a dissertation for the degree of Doctor of Philosophy. Helen Blau, Primary Adviser I certify that I have read this dissertation and that, in my opinion, it is fully adequate in scope and quality as a dissertation for the degree of Doctor of Philosophy. Michael Longaker I certify that I have read this dissertation and that, in my opinion, it is fully adequate in scope and quality as a dissertation for the degree of Doctor of Philosophy. Juan Santiago I certify that I have read this dissertation and that, in my opinion, it is fully adequate in scope and quality as a dissertation for the degree of Doctor of Philosophy. Robert Sapolsky Approved for the Stanford University Committee on Graduate Studies. Patricia J. Gumport, Vice Provost for Graduate Education This signature page was generated electronically upon submission of this dissertation in electronic format. An original signed hard copy of the signature page is on file in University Archives.
    [Show full text]
  • Dissertation Published Version
    Zurich Open Repository and Archive University of Zurich Main Library Strickhofstrasse 39 CH-8057 Zurich www.zora.uzh.ch Year: 2018 Biochemical and regulatory aspects of DNA double-strand break repair Godau, Julia Eileen Posted at the Zurich Open Repository and Archive, University of Zurich ZORA URL: https://doi.org/10.5167/uzh-170542 Dissertation Published Version Originally published at: Godau, Julia Eileen. Biochemical and regulatory aspects of DNA double-strand break repair. 2018, University of Zurich, Faculty of Science. Biochemical and Regulatory Aspects of DNA Double-Strand Break Repair Dissertation zur Erlangung der naturwissenschaftlichen Doktorwürde (Dr. sc. nat.) vorgelegt der Mathematisch-naturwissenschaftlichen Fakultät der Universität Zürich von Julia Eileen Godau aus Deutschland Promotionskommission Prof. Dr. Alessandro A. Sartori (Vorsitz und Leitung der Dissertation) Prof. Dr. Joao Matos PD. Dr. Pavel Janscak Prof. Dr. Matthias Altmeyer Zürich, 2018 Contents Abbreviations v Summary vii Zusammenfassung ix 1 Introduction 1 1.1 Genome instability - A hallmark of cancer . 1 1.2 DNA damage response . 2 1.3 DNA repair . 3 1.3.1 DSB repair . 4 1.3.2 Meiotic recombination . 6 1.3.3 Fanconi anemia pathway of ICL repair . 7 1.4 Post-translational modifications . 10 1.5 CtIP . 11 1.5.1 Sae2/Ctp1/CtIP protein family . 11 1.5.2 CtIP promotes DNA-end resection . 13 1.5.3 Regulation of CtIP by PTMs . 15 1.5.4 CtIP and its connection to cancer development and therapy . 18 1.6 SLX4 - A nuclease scaffold . 19 1.7 PIN1 . 22 1.7.1 PIN1 - A molecular switch regulating diverse pathways .
    [Show full text]
  • GEOFFREY BEENE CANCER RESEARCH CENTER 10 Year Report, 2007–2017
    GEOFFREY BEENE CANCER RESEARCH CENTER 10 Year Report, 2007–2017 10 YEAR REPORT | 2007–2017 2 COVER IMAGES, CLOCKWISE FROM TOP LEFT: Tumor- and stromal cell-derived cathepsin S expression in primary breast cancer. Shown here is an immunofluorescence image of a human breast cancer specimen stained for the cysteine protease cathepsin S in red, and tumor cells in green. Cathepsin S expression, which is typically associated with immune cells such as macrophages, is expressed in a subset of breast carcinoma cells, and may endow them with the ability to metastasize to the brain The Iacobuzio lab and Kellan Lutz, an ambassador for the Geoffrey Beene Foundation Epifluorescent imaging of transparent casper zebrafish transplanted with the human-derived PC3 prostate cancer cell line exhibits dissemination solely to the spinal column Epifluorescent imaging of transparent casper zebrafish transplanted with the zebrafish- derived ZMEL1 melanoma cell line exhibits widely disseminated tumors to the skin, eyes, muscles, and brain. Image by Isabella Kim of the White lab Ping Chi and lab members Confocal microscopy shows that the nucleolar structure of hematopoietic stem cells is altered with Stag2 loss of function. Image by Aaron Viny of the Levine lab Scott Lowe and lab member 3 GEOFFREY BEENE CANCER RESEARCH CENTER CONTENTS Welcome . .2 Supporting Innovation through the Years . 5. Milestones . 6 Highlights of Breakthrough Projects . 8 Retreats and Special Conferences . 14. Supporting Novel Research . .16 Faculty . 18. Graduate Students . .19 Q&A with Barry Taylor . .19 Financial Statistics . 20 Research Grants . 21 Publications . 38 Shown are intestinal organoids derived from transgenic shRen mice in which renilla luciferase is suppressed by doxycycline .
    [Show full text]