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NSABB June-July 2005 Meeting Agenda
First Meeting of the National Science Advisory Board for Biosecurity June 30 – July 1, 2005 Hyatt Regency Bethesda 7400 Wisconsin Ave. Bethesda, Maryland, 20814 USA Hotel Phone: 301-657-1234 Agenda Webcast: To watch the live webcast of the meeting, click here. The webcast can only be viewed when the meeting is in session at 8:00am-6:00pm on June 30 and at 8:00am-1:30pm on July 1 Eastern Time. You will need RealOne Player to view the webcast. If you do not already have RealOne Player on your computer, download here. Presentation slides: To access the following PowerPoint presentations, click on the presentation titles below. June 30, 2005 Opening Remarks and Swearing in Ceremony Elias Zerhouni, M.D. Director of the National Institutes of Health (NIH) Chair's Remarks and Agenda Overview Dennis L. Kasper, M.D. NSABB Chair Harvard Medical School Introduction of NSABB Members NSABB Structure and Operations Thomas Holohan, M.D. NSABB Executive Director, NIH Office of Biotechnology Activities Break Perspectives on Biosecurity in the Life Sciences NSABB Voting Members Impetus for NSABB: Enhancing Biosecurity on the Life Sciences Rajeev Venkayya, M.D. Special Assistant to the President, Senior Director for Biological and Chemical Defense White House Homeland Security Council Perspectives on Biosecurity in the Life Sciences NSABB Ex Officio Members Lunch Session I- The Development of Criteria for Identifying Dual Use Research and Research Results Introduction: Issues of Relevance to Criteria Development Arturo Casadevall, M.D., Ph.D. Professor of Medicine and of Microbiology & Immunology and Chief of Infectious Diseases Albert Einstein College of Medicine National Research Council Perspective: Experiments of Concern Ron Atlas, Ph.D. -
USA Education Ph.D., Biology, Massachusetts Institute of Tech
Victor R. Ambros, Ph.D. Silverman Professor of Natural Sciences Program in Molecular Medicine University of Massachusetts Medical School373 Plantation Street, Suite 306 Worcester, MA 01605 (508) 856-6380 [email protected] Personal Born: Hanover, NH, USA on December 1, 1953 Citizenship: USA Education Ph.D., Biology, Massachusetts Institute of Technology, Cambridge, MA 1976-1979 Thesis Title: The protein covalently linked to the 5' end of poliovirus RNA Advisor: Dr. David Baltimore B.S., Biology, Massachusetts Institute of Technology, Cambridge, MA 1971-1975 Professional Appointments Silverman Professor of Natural Sciences 2009-present Co-Director, RNA Therapeutics Institute 2009-2016 Professor, Program in Molecular Medicine 2008-present University of Massachusetts Medical School, Worcester, MA Professor of Genetics, Dartmouth Medical School 2001-2007 Professor, Biological Sciences, Dartmouth Medical School 1996-2001 Associate Professor, Biological Sciences, Dartmouth Medical School 1992-1996 Associate Professor, Department of Cellular and Development Biology, 1988-1992 Harvard University, Cambridge, MA Assistant Professor, Department of Cellular and Development Biology, 1985-1988 Harvard University, Cambridge, MA Postdoctoral Research 1979-1985 Supervisor: Dr. H. Robert Horvitz Massachusetts Institute of Technology, Cambridge, MA Graduate Research 1976-1979 Supervisor: Dr. David Baltimore Massachusetts Institute of Technology, Cambridge, MA Research Assistant 1975-1976 Supervisor: Dr. David Baltimore Center for Cancer Research, -
2012 Annual Report
Memorial Sloan-Kettering Cancer Center 2012 ANNUAL REPORT A SHARED VISION A SINGULAR MISSION Nurse practitioner Naomi Cazeau, of the Adult Bone Marrow Transplant Service. PING CHI PHYSICIAN-SCIENTIST 10 STEPHEN SOLOMON ALEXANDER RUDENSKY INTERVENTIONAL IMMUNOLOGIST RADIOLOGIST 16 12 VIVIANE TABAR The clinicians and scientists of NEUROSURGEON Memorial Sloan-Kettering share a vision and 18 a singular mission — to conquer cancer. STEPHEN LONG STRUCTURAL BIOLOGIST They are experts united against a 20 SIMON POWELL complex disease. Each type of cancer R ADIATION ONCOLOGIST 24 ETHEL LAW is different, each tumor is unique. Set free NURSE PRACTITIONER in surroundings that invite the sharing of 26 ideas and resources, they attack the CHRISTINA LESLIE complexity of cancer from every angle COMPUTATIONAL BIOLOGIST and every discipline. 34 SCOTT ARMSTRONG PEDIATRIC ONCOLOGIST 30 TO JORGE REIS-FILHO EXPERIMENTAL PATHOLOGIST CONQUER 38 CANCER 04 Letter from the Chairman and the President A complete version of this report — 42 Statistical Profile which includes lists of our donors, 44 Financial Summary doctors, and scientists — 46 Boards of Overseers and Managers is available on our website at 49 The Campaign for Memorial Sloan-Kettering www.mskcc.org/annualreport. 4 5 Letter from the Chairman In 2012 the leadership of Memorial Sloan-Kettering endorsed Douglas A. Warner III These programmatic investments require leadership and and the President a $2.2 billion investment in a clinical expansion that will set vision. Our new Physician-in-Chief, José Baselga, joined the stage for a changing care paradigm into the next decade us on January 1, 2013. An internationally recognized and beyond. -
The BBVA Foundation Frontiers of Knowledge Award in Biomedicine Goes to Tony Hunter, Joseph Schlessinger and Charles Sawyers
The BBVA Foundation Frontiers of Knowledge Award in Biomedicine goes to Tony Hunter, Joseph Schlessinger and Charles Sawyers for opening the door to the personalized treatment of cancer The winners represent the three steps in research leading to this advance: Tony Hunter discovered tyrosine kinases, Joseph Schlessinger identified the principle through which they function, and Charles Sawyers brought this knowledge to the clinic and the development of novel cancer therapies Their contributions served initially to treat a variety of leukemia, transforming it from a fatal into a chronic disorder, but have since given rise to effective therapies for lung and breast cancer, melanoma and lymphomas, among other conditions José Baselga, Physician-in-Chief at the Memorial Sloan Kettering Cancer Center in New York and nominator of Charles Sawyers, described the contributions of the three laureates as marking “the birth of personalized anti-cancer medicine” Madrid, January 27, 2015.- The BBVA Foundation Frontiers of Knowledge Award in the Biomedicine category is shared in this seventh edition by Tony Hunter, professor and Director of the Salk Institute Cancer Center in La Jolla, California; Joseph Schlessinger, Chairman of the Department of Pharmacology at Yale University School of Medicine, New Haven, and Charles Sawyers, Human Oncology and Pathogenesis Program Chair at the Memorial Sloan Kettering Cancer Center in New York, for “carving out the path that led to the development of a new class of successful cancer drugs.” For José Baselga, Physician-in-Chief -
Profile of Gary Ruvkun
PROFILE Profile of Gary Ruvkun wash in the faint glow of a fluo- Brush with Molecular Biology rescent lamp, a pair of serpentine The story of Ruvkun’s metamorphosis Anematode worms lie on a Petri from a keen undergraduate into a leading plate, their see-through bodies light in his field of study begins at Har- magnified 100-fold by one of several vard University, where he enrolled in microscopes arrayed in a darkened bay in a Ph.D. program in 1976 upon returning National Academy of Sciences member to the United States. Like many other Gary Ruvkun’s laboratory at Massachu- scientific institutions across the world in setts General Hospital. While one of the the mid-1970s, Harvard was astir with the worms wiggles its way around the plate, promise of recombinant DNA technol- the other shows no signs of life, ogy, and Ruvkun wasted no time em- its midsection ruptured and its innards bracing its tools. “My undergraduate strewn asunder. A filter slides into place, education had not prepared me at all for and the worms are bathed in a dull recombinant DNA, but I immersed my- green haze. The wiggling worm has a bea- self into its culture at Harvard, much of con of nerve cells in its head, the ganglia which was James Watson’s creation from lit up by a genetic trick that has rescued a decade earlier,” Ruvkun says. Propelled the worm from death; its neighbor wears Gary Ruvkun. by a desire to be a part of the culture of no such beacon. The worms were deprived basic molecular biology, all while per- of a tiny RNA molecule, called a micro- forming science with the potential to im- RNA, which helps shepherd them through not 5-year-old children. -
Michael S. Brown, MD
DISTINGUISHED PHYSICIANS AND Michael S. Brown, M.D. Sir Richard Roberts, Ph.D. Winner, 1985 Nobel Prize in Physiology or Medicine Winner, 1993 Nobel Prize in Physiology or Medicine MEDICAL SCIENTISTS MENTORING Winner, 1988 Presidential National Medal of Science A globally prominent biochemist and molecular biologist, DELEGATES HAVE INCLUDED... Dr. Brown received the world’s most prestigious medical Dr. Roberts was awarded the Nobel Prize for his prize for his work describing the regulation of the groundbreaking contribution to discovering RNA splicing. cholesterol metabolism. His work laid the foundation for Dr. Roberts is dedicating his future research to GMO crops the class of drugs now called statins taken daily by more than 20 million and food sources, and demonstrating the effect they have on humanity. — GRANDg MASTERS — people worldwide. Ferid Murad, M.D., Ph.D. Mario Capecchi, Ph.D. Boris D. Lushniak, M.D., M.P.H Winner, 1998 Nobel Prize in Physiology or Medicine Academy Science Director The Surgeon General of the United States (acting, 2013-2014) Winner, 2007 Nobel Prize in Physiology or Medicine A world-renowned pioneer in biochemistry, Dr. Murad’s Winner, 2001 National Medal of Science Rear Admiral Lushniak, M.D., M.P.H., was the United award-winning research demonstrated that nitroglycerin Winner, 2001 Lasker Award States’ leading spokesperson on matters of public health, and related drugs help patients with heart conditions by Winner, 2003 Wolf Prize in Medicine overseeing the operations of the U.S. Public Health Service releasing nitric oxide into the body, thus relaxing smooth Mario Capecchi, Ph.D., a biophysicist, is a Distinguished Commissioned Corps, which consists of approximately muscles by elevating intracellular cyclic GMP, leading to vasodilation and Professor of Human Genetics at the University of Utah School of Medicine. -
2008 Harvard / Paul F
The 2008 Harvard / Paul F. Glenn Symposium on Aging June 23, 2008 Paul F. Glenn Laboratories for the Biological Mechanisms of Aging Welcome to the 3rd Annual Harvard/Paul F. Glenn Symposium on Aging. Each year, the Paul F. Glenn Laboratories host the Harvard Symposium on Aging with a mission to educate the wider research community about advancements in this fast-paced field and to stimulate collaborative research in this area. We have been fortunate to have many of the leaders in the aging field speak at these symposia. As a result, attendees come not only from the Harvard research community but from across the nation and from overseas for this one day event. We are glad you could join us here today. The reasons for accelerating research molecular biology of aging are clear. First and foremost, the number of aged individuals in developed countries is growing rapidly, which is going to place an unprecedented burden on the families and the economies of those nations. Because chronic illness in the elderly is a major medical cost, enormous savings would be achieved if mortality and morbidity could be compressed within a shorter duration of time at the end of life. A study by the RAND Corporation in 2006 concluded that advances in medicine arising from aging research would be 10-100 times more cost-effective than any other medical breakthrough. Advances in aging research have shown that it is possible to extend the healthy lifespan of laboratory animals through genetic and pharmacological means. Many leaders in the aging field predict that significant strides will be made in understanding how human health and lifespan are regulated, leading to novel medicines to forestall and treat diseases of aging such as diabetes, cancer, Alzheimer’s and heart disease. -
A Review of J. Craig Venter's a Life Decoded
A peer-reviewed electronic journal published by the Institute for Ethics and Emerging Technologies ISSN 1541-0099 17(1) – March 2008 A review of J. Craig Venter’s A Life Decoded Randy Mayes, Duke University Journal of Evolution and Technology - Vol. 17 Issue 1 – March 2008 - pgs 71-72 http://jetpress.org/v17/mayes.htm In the early 1980s, a number of researchers suggested sequencing and mapping the human genome to help the science community better understand diseases and evolution. Following the announcement that the human genome had been sequenced, scientists wrote in peer-reviewed journals that we are not as hardwired as was once believed, and that the sequencing of the genome was just the beginning. Today, researchers have a new set of goals. In popular journalism, however, the science was lost in the shuffle. The media focused more on the dynamics of the conflicting philosophies of the private and public projects. This emphasis is also clear in the titles of several books chronicling the Human Genome Project, all appearing prior to the recent release of Craig Venter’s autobiography, A Life Decoded: My Genome: My Life (2007). Readers will find that Robert Cook-Deegan’s The Gene Wars (1995) and The Common Thread by Sir John Sulston and Georgina Ferry (2002), both written by insiders, are biased towards the philosophy of the public project, a commons approach. Sulston is a socialist who grows runner beans and drives a second hand car. By contrast, Venter travels in Lear jets and conducts business from his yacht. Three other books are more objective. -
Signature Redacted Certified By: __Signature Redacted
Genetic Regulation of Cell Extrusion in Caenorhabditis elegans By Vivek Kumar Dwivedi M. Tech. Biochemical Engineering and Biotechnology Indian Institute of Technology Delhi, 2012 Submitted to the Department of Biology in Partial Fulfillment of the Requirements for the Degree of Doctor of Philosophy at the Massachusetts Institute of Technology June 2019 2019 Massachusetts Institute of Technology. All rights reserved. The author hereby grants to MIT permission to reproduce and to distribute publicly paper and electronic copies of this thesis document in whole or in part in any medium now known or hereafter created. Signature redacted Signature of Author: Department of Biology, May 28, 2019 Certified by: __Signature redacted H. Roiert Horvitz Professor of Biology Thesis Supervisor Accepted by: Signature redacted MASSACHUSETS INSTITUTE Amy . eag OF TECHNOLOGY- Professor of Biology Graduate Committee MAY 312 Co-Chair, Biology LIBRARIES ARCHIVES 1 Genetic Regulation of Cell Extrusion in Caenorhabditis elegans by Vivek Kumar Dwivedi Submitted to the MIT Department of Biology on May 28, 2019 in Partial Fulfillment of the Requirements for the Degree of Doctor of Philosophy in Biology Abstract Programmed elimination of cells occurs during animal development and homeostasis to maintain appropriate cell numbers. One evolutionarily conserved method by which organisms eliminate cells in a programmed manner is by cell- autonomous activation of the caspase-mediated apoptosis pathway, which produces a corpse that is engulfed and degraded by phagocytic cells. Cell elimination can also occur by a different method, called cell extrusion, in which the cell to be eliminated is squeezed out from a layer of cells, such as an epithelium. -
100Th RAF Raffle – Kurt Durlesser and Evan Garcia OHRPP Updates
Marcia L. Smith November 14, 2019 2 Welcome & Announcements 2009 - 2019 3 4 Agenda • Office of the Human Research Protection Program ◦ Roll-out of PI and Faculty Assurances – Moore Rhys • Extramural Fund Management ◦ Closing Expired Funds – Will Murdoch ◦ ERS Listserv Changes – Will Murdoch ◦ Ascend: Expenditure Type – Yoon Lee • UCLA Trivia and 100th RAF Raffle – Kurt Durlesser and Evan Garcia OHRPP Updates November 14, 2019 – 100th RAF 2 OHRPP Updates Annual PI and FS Assurances Human Research News Training opportunities 3 Annual PI and Faculty Sponsor Assurances In order to keep track of active studies that don’t require continuing review, OHRPP has worked with ORIS to create a mechanism for a yearly check-in with investigators. 4 Annual PI and Faculty Sponsor Assurances These will be required (in lieu of continuing review) to continue the following types of research: • Certified exempt • Studies determined eligible for expedited review • Research that has progressed to the point of only collecting results of clinical care procedures/tests for follow-up • Research that has progressed to the point of data analysis only • Studies where a UCLA IRB is relying on another IRB 5 Annual PI and Faculty Sponsor Assurances Automatic email notices (with instructions) will be sent out from the webIRB system: - 9 months after the initial approval (or last annual assurance) – 3 months before the assurance is due - 10 months after the initial approval (or last annual assurance) – 2 months before the assurance is due - 11 months after the initial approval (or last annual assurance – 1 month before the assurance is due - 12 months after the initial approval (or last annual assurance) – the day the assurance is due 6 Annual PI and Faculty Sponsor Assurances Important: If the PI (and faculty sponsor, if applicable) doesn’t complete the annual assurance, the study will be administratively closed PI proxies cannot complete the assurance 7 Annual PI and Faculty Sponsor Assurances If the PI has a faculty sponsor, the faculty advisor must complete their assurance first. -
Lasker Awards Honor Trailblazers in Medical Research and Public Service
EMBARGOED FOR RELEASE UNTIL SEPTEMBER 14, 2009 FROM: The Albert and Mary Lasker Foundation New York, New York CONTACT: Rubenstein Communications, Inc. Charles Zehren 212-843-8590 [email protected] Janet Wootten 212-843-8032 [email protected] 2009 LASKER AWARDS HONOR TRAILBLAZERS IN MEDICAL RESEARCH AND PUBLIC SERVICE: John Gurdon and Shinya Yamanaka, for Breakthrough Research in Nuclear Reprogramming and Stem Cells Brian J. Druker, Nicholas B. Lydon and Charles L. Sawyers, for Lifesaving Discoveries in Treatment of Leukemia Michael R. Bloomberg, for Landmark Policy and Philanthropic Initiatives to Reduce Tobacco Use and Foster Public Health New York, Sept. 13, 2009 - The Albert and Mary Lasker Foundation, which for 64 years has championed the greatest breakthroughs in medical research, today announced the winners of the 2009 Lasker Awards for outstanding accomplishments in basic medical and clinical medical research, and public service. The three awards—recognized as the most prestigious medical research awards in the United States today— honor six visionaries whose insight and courage has led to dramatic advances that will prevent disease and prolong life. John Gurdon of Cambridge University and Shinya Yamanaka of Kyoto University will receive the 2009 Albert Lasker Basic Medical Research Award for breakthrough discoveries into the process that instructs specialized adult cells to form stem cells. Brian J. Druker of Oregon Health & Science University, Nicholas B. Lydon, formerly of Novartis, and Charles L. Sawyers of Memorial Sloan-Kettering Cancer Center will receive the 2009 Lasker~DeBakey Clinical Medical Research Award for groundbreaking work on the treatment of chronic myeloid leukemia. New York City Mayor Michael R. -
LLS AR 2005.Pdf
LEUKEMIA LYMPHOMA MYELOMA 2005 Annual Report our mission Cure leukemia, Over its history, the Society has been the recognized leader in the fight against leukemia. Our name change to The Leukemia & Lymphoma lymphoma, Society in 2000 was simply perception catching up to reality. The Hodgkin’s Society’s objective is to find cures for all blood cancers, and to be disease and the leading resource for patients battling all of these cancers. myeloma, and This year, the Society took the first step in making access to specific improve the information and services simpler for patients with these cancers. quality of life We developed a color-coding system for the three main categories of blood cancers: Our new signature colors are green for leukemia, of patients and gold for lymphoma and blue for myeloma. Any information that their families. is relevant to all the diseases is coded burgundy. All print materials prepared for patients during this year reflect the new system, making access to important information and resources more efficient. You’ll also see our new colors in such e-newsletters as LeukemiaLinks, LymphomaLinks and MyelomaLinks. The next step will be to extend the new system to other venues, including access to information on the Society’s Web site. This year’s Annual Report displays the new colors with pride. They represent the ongoing efforts to constantly improve on the ways the Society serves and supports patients and those who love and 2 005 | care for them. AN N U AL R EPOR T leadership message We are fortunate to be able to report that fiscal year 2005 was a banner year for the Society in many ways.