The Road to Discovery: a Short History of Cold Spring Harbor Laboratory
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Volume Xlvii--Part 1 Cold Spring Harbor Symposia on Quantitative Biology
COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY VOLUME XLVII--PART 1 COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY VOLUME XLVII STRUCTURES OF DNA COLD SPRING HARBOR LABORATORY 1983 COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY VOLUME XLVII 1983 by The Cold Spring Harbor Laboratory International Standard Book Number 0-87969-046-1 International Standard Serial Number 0091-7451 Library of Congress Catalog Card Number 34-8174 Printed in the United States of America All rights reserved COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY Founded in 1933 by REGINALD G. HARRIS Director of the Biological Laboratory 1924 to 1936 Previous Symposia Volumes I (1933) Surface Phenomena XXIH (1958) Exchange of Genetic Material: Mechanism and II (1934) Aspects of Growth Consequences IU (1935) Photochemical Reactions XXIV (1959) Genetics and Twentieth Century Darwinism IV (1936) Excitation Phenomena XXV (! 960) Biological Clocks V (1937) Internal Secretions XXVI (1961) Cellular Regulatory Mechanisms VI (1938) Protein Chemistry XXVII (1962) Basic Mechanisms in Animal Virus Biology VII (1939) Biological Oxidations XXVIU (1963) Synthesis and Structure of Macromolecules VIII (1940) Permeability and the Nature of Cell Membranes XXIX (1964) Human Genetics IX (1941) Genes and Chromosomes: Structure and Organization XXX (1965) Sensory Receptors X (1942) The Relation of Hormones to Development XXXI (1966) The Genetic Code XI (1946) Heredity and Variation in Microorganisms XXXII (1967) Antibodies XII (1947) Nucleic Acids and Nucleoproteins XXXIU (1968) -
Barbara Mcclintock
Barbara McClintock Lee B. Kass and Paul Chomet Abstract Barbara McClintock, pioneering plant geneticist and winner of the Nobel Prize in Physiology or Medicine in 1983, is best known for her discovery of transposable genetic elements in corn. This chapter provides an overview of many of her key findings, some of which have been outlined and described elsewhere. We also provide a new look at McClintock’s early contributions, based on our readings of her primary publications and documents found in archives. We expect the reader will gain insight and appreciation for Barbara McClintock’s unique perspective, elegant experiments and unprecedented scientific achievements. 1 Introduction This chapter is focused on the scientific contributions of Barbara McClintock, pioneering plant geneticist and winner of the Nobel Prize in Physiology or Medicine in 1983 for her discovery of transposable genetic elements in corn. Her enlightening experiments and discoveries have been outlined and described in a number of papers and books, so it is not the aim of this report to detail each step in her scientific career and personal life but rather highlight many of her key findings, then refer the reader to the original reports and more detailed reviews. We hope the reader will gain insight and appreciation for Barbara McClintock’s unique perspective, elegant experiments and unprecedented scientific achievements. Barbara McClintock (1902–1992) was born in Hartford Connecticut and raised in Brooklyn, New York (Keller 1983). She received her undergraduate and graduate education at the New York State College of Agriculture at Cornell University. In 1923, McClintock was awarded the B.S. -
Curriculum Vitae
Curriculum vitae BRUCE WILLIAM STILLMAN PLACE AND DATE OF BIRTH October 16, 1953, Melbourne, Australia ADDRESS Cold Spring Harbor Laboratory 1 Bungtown Road Cold Spring Harbor, New York 11724 Phone: (516) 367-8383 Email: [email protected] NATIONALITY Australian; Permanent Resident, U.S.A. EDUCATION Glen Waverley High School, Victoria, Australia (1966-69) Sydney Boys’ High School, N.S.W., Australia (1970-71) B.Sc., First Class Honours, University of Sydney (1972-75) Ph.D., Australian National University (1976-79) POSITIONS Postgraduate Student, Department of Microbiology John Curtin School of Medical Research Australian National University (1976-1979) Postdoctoral Fellow, Cold Spring Harbor Laboratory (1979-80) Staff Investigator, Cold Spring Harbor Laboratory (1981-82) Senior Staff Investigator, Cold Spring Harbor Laboratory (1983-1985) Professor, Cold Spring Harbor Laboratory (1985 - present) Assistant Director, Cold Spring Harbor Laboratory (1990-1993) Director, Cold Spring Harbor Laboratory Cancer Center (1992-present) Director, Cold Spring Harbor Laboratory (1994-2003) (Chief Executive Officer title added by CSHL Board, November 2000) President, Cold Spring Harbor Laboratory, (2003-present) Curriculum vitae: Bruce W. Stillman 2 HONORS and AWARDS Commonwealth Postgraduate Award (1976-1978); Damon Runyon-Walter Winchell Cancer Fund Fellow (1979-1980); Rita Allen Foundation Scholar (1982-1987); Merit Award - National Institutes of Health (1986); The Royal Society (London), Elected Fellow (1993); Julian Wells Medal and Lecture, Genome -
Dr Bruce William Stillman AO
Dr Bruce William Stillman AO The degree of Doctor of Science (honoris causa) was conferred upon Dr Bruce Stillman AO at the Faculty of Economics and Business graduation ceremony held at 2.00pm on 9 May 2008. The Deputy Chancellor Mr Alan Cameron AM conferring the honorary degree upon Dr Stillman, photo, copyright Memento Photography. Citation Deputy Chancellor, I have the honour to present Bruce William Stillman for admission to the degree of Doctor of Science (honoris causa). Dr Bruce Stillman is President of Cold Spring Harbor Laboratory. A native of Australia, he obtained a Bachelor of Science degree with honors at The University of Sydney and a PhD at the John Curtin School of Medical Research at the Australian National University. He then moved to Cold Spring Harbor Laboratory as a Postdoctoral Fellow in 1979 and has been at the Laboratory ever since, being promoted to the scientific staff in 1981. Dr. Stillman has been Director of the Cancer Center at Cold Spring Harbor Laboratory since 1992, a position he still holds. In 1994, he succeeded Nobel Prize winner Dr James D Watson as Director of Cold Spring Harbor Laboratory and was appointed President in 2003. Dr Stillman's research focuses on the mechanism and regulation of duplication of DNA and chromatin in cells, a process that ensures accurate inheritance of genetic information from one cell generation to the next. For these research accomplishments, Dr Stillman has received a number of honors including election as a Fellow of The Royal Society in 1993. In 1994, Dr Stillman was awarded the Julian Wells Medal and in 1999, Dr Stillman was appointed an Officer of the Order of Australia for service to scientific research. -
Famous Female Scientists
Appendix B: Scientific Contributions of Thirteen Outstanding Female Scientists Scientific Contributions of Thirteen Outstanding Female Scientists Gerty Cori, with her husband, received international recognition for discovering how glucose converts to glycogen (Cori cycle). This husband and wife team won the 1947 Nobel Prize in physiology or medicine for “discovering the course of the catalytic conversion of glycogen” (mechanism for blood glucose regulation). Cori’s later studies on enzymes and hormones advanced research in diabetes treatment, contributing new understandings that missing enzymes resulted from defective genes. This laid the foundation for future studies of genetic defects in humans. Her research profoundly affected diabetes treatment, allowing physicians to understand how the body stores glucose by converting it predominantly into glycogen, which the body then uses for energy. Despite her significant research, she fought discrimination and nepotism within the Gerty Radnitz Cori scientific community. In 1947, the same year she became the first American woman and the (1896–1954) third worldwide to receive a Nobel Prize in the sciences, she achieved full professor status in biochemistry at Washington University, St. Louis. In 1950, President Harry Truman appointed her to the Board of Directors of the National Science Foundation. Considered the most famous of all women scientists, this Polish researcher “extraordinarie” was the first person (male or female) to win two Nobel Prizes. At age 16, she had already won a gold medal at the Russian lycée in Poland upon completion of her secondary education. In 1891, almost penniless, she began her education at the Sorbonne in Paris and later became the first woman professor to teach there. -
Mothers of Invention: Women in Technology
Mothers of Invention: Women in Technology n old adage counsels, “Maternity Rideout (AZT), M. Katherine Holloway and is a matter of fact… paternity is Chen Zhao (protease inhibitors), and Diane a matter of opinion.” And indeed, Pennica (tissue plasminogen activator).2 Awhen it comes to people, the evidence of By 1998, women accounted for 10.3 who physically bears the child is visible and percent of all U.S.–origin patents granted undeniable. With the gestation of ideas, annually. Innovation professionals believe this however, lineage is less clear. percentage will continue to increase. A recent The evidence for women’s role in survey of one thousand U.S. researchers technology has been obscured historically. yielded the names of twenty U.S. scientists Only two percent of the fi ve hundred Nobel under the age of forty who have demonstrated Prize Laureates recognized for scientifi c once-in-a-generation insight. Nine of them— achievement are women. As recently as the almost half—are women.3 Jennifer A. Kurtz early 1980s, U.S. Patent and Trademark Offi ce records show that only 2.8 percent of patents Research Fellow, Indiana went to women each year. This participation Business Research Center, rate did not differ much from the 1 percent or Women must Kelley School of Business, so of patents that went to women in the period increasingly pursue Indiana University from 1790 to 1895.1 Young women have had relatively few role science and models to encourage their pursuit of scientifi c and technological adventures. That pattern has technology to ensure begun to change as women are increasingly that the future needs present in all dimensions of the innovation life cycle: knowledge creation, technology transfer, for a skilled U.S. -
Balcomk41251.Pdf (558.9Kb)
Copyright by Karen Suzanne Balcom 2005 The Dissertation Committee for Karen Suzanne Balcom Certifies that this is the approved version of the following dissertation: Discovery and Information Use Patterns of Nobel Laureates in Physiology or Medicine Committee: E. Glynn Harmon, Supervisor Julie Hallmark Billie Grace Herring James D. Legler Brooke E. Sheldon Discovery and Information Use Patterns of Nobel Laureates in Physiology or Medicine by Karen Suzanne Balcom, B.A., M.L.S. Dissertation Presented to the Faculty of the Graduate School of The University of Texas at Austin in Partial Fulfillment of the Requirements for the Degree of Doctor of Philosophy The University of Texas at Austin August, 2005 Dedication I dedicate this dissertation to my first teachers: my father, George Sheldon Balcom, who passed away before this task was begun, and to my mother, Marian Dyer Balcom, who passed away before it was completed. I also dedicate it to my dissertation committee members: Drs. Billie Grace Herring, Brooke Sheldon, Julie Hallmark and to my supervisor, Dr. Glynn Harmon. They were all teachers, mentors, and friends who lifted me up when I was down. Acknowledgements I would first like to thank my committee: Julie Hallmark, Billie Grace Herring, Jim Legler, M.D., Brooke E. Sheldon, and Glynn Harmon for their encouragement, patience and support during the nine years that this investigation was a work in progress. I could not have had a better committee. They are my enduring friends and I hope I prove worthy of the faith they have always showed in me. I am grateful to Dr. -
Annotated Bibliography: Women in Physics, Astronomy, and Related Disciplines
Annotated Bibliography: Women in Physics, Astronomy, and Related Disciplines Abir Am, Pnina and Dorinda Outram, eds. Uneasy Careers and Intimate Lives: Women in Science, 1787-1979. New Brunswick, NJ: Rutgers University Press, 1987. Abir Am and Outram’s volume includes a collection of essays about women in science that highlight the intersection of personal and professional spheres. All of the articles argue that the careers of women scientists are influenced by their family lives and that their family lives are impacted because of their scientific careers. This text is significant in two ways: first, it is one of the earliest examples of scholarship that moves beyond the recovering women in science, but placing them in the context of their home and work environments. Second, it suggests that historians of science can no longer ignore the private lives of their historical subjects. This volume contains four articles relating to women in physics and astronomy: Marilyn Bailey Ogilvie’s “Marital Collaboration: An Approach to Science” (pages 104-125), Sally Gregory Kohlstedt’s “Maria Mitchell and the Advancement of Women in Science” (pages 129-146), Helena M. Pycior’s “Marie Curie’s ‘Anti-Natural Path’: Time Only for Science and Family” (pages 191-215), and Peggy Kidwell’s “Cecelia Payne-Gaposchkin: Astronomy in the Family” (pages 216-238). As a unit, the articles would constitute and interesting lesson on personal and professional influences. Individually, the articles could be incorporated into lessons on a single scientist, offering a new perspective on their activities at work and at home. It complements Pycior, Slack, and Abir Am’s Creative Couples in the Sciences and Lykknes, Opitz, and Van Tiggelen’s For Better of For Worse: Collaborative Couples in the Sciences, which also look at the intersection of the personal and professional. -
Timeline of Genomics (1901–1950)*
Research Resource Timeline of Genomics (1901{1950)* Year Event and Theoretical Implication/Extension Reference 1901 Hugo de Vries adopts the term MUTATION to de Vries, H. 1901. Die Mutationstheorie. describe sudden, spontaneous, drastic alterations in Veit, Leipzig, Germany. the hereditary material of Oenothera. Thomas Harrison Montgomery studies sper- 1. Montgomery, T.H. 1898. The spermato- matogenesis in various species of Hemiptera and ¯nds genesis in Pentatoma up to the formation that maternal chromosomes only pair with paternal of the spermatid. Zool. Jahrb. 12: 1-88. chromosomes during meiosis. 2. Montgomery, T.H. 1901. A study of the chromosomes of the germ cells of the Metazoa. Trans. Am. Phil. Soc. 20: 154-236. Clarence Ervin McClung postulates that the so- McClung, C.E. 1901. Notes on the acces- called accessory chromosome (now known as the \X" sory chromosome. Anat. Anz. 20: 220- chromosome) is male determining. 226. Hermann Emil Fischer(1902 Nobel Prize Laure- 1. Fischer, E. and Fourneau, E. 1901. UberÄ ate for Chemistry) and Ernest Fourneau report einige Derivate des Glykocolls. Ber. the synthesis of the ¯rst dipeptide, glycylglycine. In Dtsch. Chem. Ges. 34: 2868-2877. 1902 Fischer introduces the term PEPTIDES. 2. Fischer, E. 1907. Syntheses of polypep- tides. XVII. Ber. Dtsch. Chem. Ges. 40: 1754-1767. 1902 Theodor Boveri and Walter Stanborough Sut- 1. Boveri, T. 1902. UberÄ mehrpolige Mi- ton found the chromosome theory of heredity inde- tosen als Mittel zur Analyse des Zellkerns. pendently. Verh. Phys -med. Ges. WÄurzberg NF 35: 67-90. 2. Boveri, T. 1903. UberÄ die Konstitution der chromatischen Kernsubstanz. Verh. Zool. -
Jacsue Kehoe 320
EDITORIAL ADVISORY COMMITTEE Marina Bentivoglio Larry F. Cahill Stanley Finger Duane E. Haines Louise H. Marshall Thomas A. Woolsey Larry R. Squire (Chairperson) The History of Neuroscience in Autobiography VOLUME 4 Edited by Larry R. Squire ELSEVIER ACADEMIC PRESS Amsterdam Boston Heidelberg London New York Oxford Paris San Diego San Francisco Singapore Sydney Tokyo This book is printed on acid-free paper. (~ Copyright 9 byThe Society for Neuroscience All Rights Reserved. No part of this publication may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopy, recording, or any information storage and retrieval system, without permission in writing from the publisher. Permissions may be sought directly from Elsevier's Science & Technology Rights Department in Oxford, UK: phone: (+44) 1865 843830, fax: (+44) 1865 853333, e-mail: [email protected]. You may also complete your request on-line via the Elsevier homepage (http://elsevier.com), by selecting "Customer Support" and then "Obtaining Permissions." Academic Press An imprint of Elsevier 525 B Street, Suite 1900, San Diego, California 92101-4495, USA http ://www.academicpress.com Academic Press 84 Theobald's Road, London WC 1X 8RR, UK http://www.academicpress.com Library of Congress Catalog Card Number: 2003 111249 International Standard Book Number: 0-12-660246-8 PRINTED IN THE UNITED STATES OF AMERICA 04 05 06 07 08 9 8 7 6 5 4 3 2 1 Contents Per Andersen 2 Mary Bartlett Bunge 40 Jan Bures 74 Jean Pierre G. Changeux 116 William Maxwell (Max) Cowan 144 John E. Dowling 210 Oleh Hornykiewicz 240 Andrew F. -
Genetics Society of America
Genetics Society of America 1992 Records, Proceedings and Reports Published as supplementary material in GENETICS, Volume 131 Prepared by The Secretary Shirleen Roeder Department of Biology Yale University New Haven, Connecticut s2 BOARDS, COMMITTEES AND REPRESENTATIVES FOR 1992 BOARD OF DIRECTORS John C. Lucchesi, President Karen Artzt A. Dale Kaiser, Vice-president Welcome Bender Shirleen Roeder, Secretary Nina V. Fedoroff Carol S. Newlon, Treasurer Barry S. Ganetzky Leland H. Hartwell, Past President Christine Guthrie John W. Drake, Editor H. Robert Horvitz GENETICSEDITORIAL BOARD John W. Drake, Editor Maureen R. Hanson Sally Lyman Allen Robert K. Herman Karen Artzt Alan G. Hinnebusch Douglas E. Berg Richard R. Hudson David Botstein Nancy A. Jenkins John E. Boynton Mark Johnston Anthony H. D. Brown Elizabeth Jones Benjamin Burr Cathy C. Laurie Marian Carlson Wen-Hsiung Li Deborah Charlesworth Trudy F. C. Mackay Peter Cherbas Patricia J. Pukkila Arthur Chovnick Trudi Schiipbach Andrew G. Clark William F. Sheridan Thomas W. Cline Michael J. Simmons Rowland H. Davis Montgomery Slatkin Robin E. Denell Gerald R. Smith Norman R. Drinkwater Steven D. Tanksley Walter F. Eanes Elizabeth Thompson Victoria G. Finnerty Bruce S. Weir Margaret T. Fuller Fred Winston Roger E. Ganschow ADMINISTRATIVE OFFICE Elaine Strass, Executive Director Barbara Abbott, Publicat~nsAssistant/ASHG Membership Coordinator Sharon Adler, Accounting Assistant Judy Ashton, Oflce Coordinator Candis Galkin, Accounting Assistant Gloria Garber, Membership and Meetings Assistant Karen Gould, Comptroller/Manager of Administration Margot Kiley, GSA Membership Coordinator Krista Koziol, Publications Manager Anne Marie Langevin, GSA Meetings Manager Marsha Ryan, ASHG Meetings Manager Jane Salomon, ASHG Special Projects Manager COMMITTEES Leland H. -
Commentary on the Nobel Prize That Has Been Granted in Medicine-Physiology, Chemistry and Physics to Noteable Female Scientists
Gaceta Médica de México. 2015;151 Contents available at PubMed www.anmm.org.mx PERMANYER Gac Med Mex. 2015;151:264-8 www.permanyer.com GACETA MÉDICA DE MÉXICO HISTORY AND PHILOSOPHY OF MEDICINE Commentary on the Nobel Prize that has been granted in Medicine-Physiology, Chemistry and Physics to noteable female scientists Arturo Zárate*, Leticia Manuel Apolinar, Renata Saucedo and Lourdes Basurto © Permanyer Publications 2015 .rehsilbup eht fo noissimrep nettirw roirp eht tuohtiw gniypocotohp ro decudorper eb yam noitacilbup siht fo trap oN trap fo siht noitacilbup yam eb decudorper ro Endocrinology, Diabetesgniypocotohp and Metabolism Researchtuohtiw eht Unit, Centro Médicoroirp Nacional, Institutonettirw Mexicano del Seguronoissimrep Social (IMSS),fo México,eht D.F., México .rehsilbup Abstract The Nobel Prize was established by Alfred Nobel in 1901 to award people who have made outstanding achievements in physics, chemistry and medicine. So far, from 852 laureates, 45 have been female. Marie Curie was the first woman to receive the Nobel Prize in 1903 for physics and eight years later also for chemistry. It is remarkable that her daughter Irene and her husband also received the Nobel Prize for chemistry in 1935. Other two married couples, Cori and Moser, have also been awarded the Nobel Prize. The present commentary attempts to show the female participation in the progress of scientific activities. (Gac Med Mex. 2015;151:264-8) Corresponding author: Arturo Zárate, [email protected] KEY WORDS: Nobel Prize. Nobel Prize winning women. Female scientists. to be awarded every year. Since 1901, this prize has ntroduction I been awarded in the areas of physics, chemistry, phys- iology and medicine to 852 persons, out of which 45 In the year of 2014, the Medicine Nobel Prize was have been women1.