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Wellcome Investigators March 2011

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Wellcome Investigators March 2011 Wellcome Trust Investigator Awards Feedback from Expert Review Group members 28 March 2011 1 Roughly 7 months between application and final outcome The Expert Review Groups 1. Cell and Developmental Biology 2. Cellular and Molecular Neuroscience (Zaf Bashir) 3. Cognitive Neuroscience and Mental Health 4. Genetics, Genomics and Population Research (George Davey Smith) 5. Immune Systems in Health and Disease (David Wraith) 6. Molecular Basis of Cell Function 7. Pathogen Biology and Disease Transmission 8. Physiology in Health and Disease (Paul Martin) 9. Population and Public Health (Rona Campbell) 2 Summary Feedback from ERG Panels • The bar is very high across all nine panels • Track record led - CV must demonstrate a substantial impact of your research (e.g. high impact journals, record of ground breaking research, clear upward trajectory etc) To paraphrase Walport ‘to support scientists with the best track records, obviously appropriate to the stage in their career’ • Notable esteem factors (but note ‘several FRSs were not shortlisted’) • Your novelty of your research vision is CRUCIAL. Don’t just carry on doing more of the same • The Trust is not averse to risk (but what about ERG panel members?) • Success rate for short-listing for interview is ~15-25% at Senior Investigator level (3-5 proposals shortlisted from each ERG) • Fewer New Investigator than Senior Investigator applications – an opportunity? • There are fewer applications overall for the second round, but ‘the bar will not be lowered’ The Challenge UoB has roughly 45 existing Wellcome Trust-funded Programme and Project Grants amounting to ~£4m p.a. in direct funds (plus ~£1.1m via ‘FEC’) How do we maximise the number of successful proposals? Do we carpet bomb the Trust with proposals? Do we work together strategically to identify and support individuals to maximise their chances of success? This scheme may not be the most suitable for you at this specific time (EC/EU, BBSRC, MRC… etc) 3 Timeline of application process Applications are accepted by the Trust on a rolling basis Upcoming Expert Review Group meeting dates • June / July 2011 • October / November 2011 • February 2012 • April / May 2012 • September 2012 The UoB Process - I CV check by Wellcome Trust (please provide confirmation email) Submit an outline proposal by email to Lorna Colquhoun in RED ([email protected]) which includes the following: • Your CV (in the format required by the Trust) • Your research vision (1000-3000 words) and how this addresses one of the Trust’s five major challenges • Details of total funding requested (to the nearest £100k) • Summary of any discussions with your Dean or Head of School • Summary of requirements for for strategic or capital investment prior to submission to Trust (note that the Trust do NOT necessarily expect this level of support) 4 The UoB Process - 2 Your proposal will be reviewed by an Advisory Group comprising: • Guy Orpen (PVC-Research; Chair) • Clive Orchard (Dean FMVS) • Peter Mathieson (Dean FMD) • Jon Keating (Dean FS) • Jeremy Tavaré (Research Director FMVS) • Andrew Dick (Research Director FMD) • Alistair Hetherington (Research Director FS) • Specialist (e.g. ERG) members co-opted as appropriate • Lorna Colquhoun (RED) The UoB Process - 3 The purpose of the UoB internal process is to: • Prepare you for an application at the most appropriate time in you career to maximise the chance of success (i.e. optimise your CV) • Advise you on how to best enhance your research vision • Avoid you being barred from reapplying at a critical career stage if unsuccessful (1/2 years) • Ensure competition between our own candidates at individual ERG panel meetings is avoided • Rationalise the number of proposals being put forward AS REQUESTED OF US BY THE TRUST At all times your FRD and RED/Finance will work with you to prepare and/or improve your proposal (if you so wish!). ERG panel members also available for expert advice. 5 The UoB Process - 4 A letter of support signed by the PVC-R is required and will be prepared by your HoS, Dean and FRD together with RED and you. This will need to detail how the ‘University’ has: • Supported your career to date • Committed to and invested in your research area • Will continue to support your research going forward Questions? Slides and notes will be made available; including ERG panel membership 6 Cell and Developmental Biology Cells, their behaviour, lifecycle and interactions with their environment. Its remit includes: • Developmental biology including neurodevelopment at all stages • Stem cells • Cell biology • Cell cycle • Extracellular matrix • Cell migration • Cell signalling • Membranes and receptors • Gene expression where the study is focused on the biology of cell function Cell and Developmental Biology • Professor Frank Grosveld (Chair), Erasmus Medical Centre, Rotterdam • Professor Dame Linda Partridge (Deputy Chair), UCL • Dr James Briscoe, MRC National Institute for Medical Research • Professor Karl Kadler, University of Manchester • Professor Robb Krumlauf, Stowers Institute for Medical Research • Professor Peter Parker, King's College London and London Research Institute, CRUK • Dr Catherine Rabouille, Hubrecht Institute, • Professor Margaret Robinson, University of Cambridge • Professor Graham Warren, Max F Perutz Laboratories • Professor Fiona Watt, Cancer Research UK Cambridge Research Institute 7 Cellular and Molecular Neuroscience To improve understanding of how the brain functions at the molecular and cellular level. Its remit includes: • Basic neurobiology • Neural signalling and function • Sensory neuroscience • Autonomic Nervous System • Neuro-immunology • Genetics with detailed phenotypic assessments at the cellular level Cellular and Molecular Neuroscience • Professor David Attwell (co-Chair), UCL • Professor David Rubinsztein (co-Chair), University of Cambridge • Professor Zafar Bashir, University of Bristol • Professor Patrick Chinnery, Newcastle University • Professor Charles ffrench-Constant, University of Edinburgh • Professor Gero Miesenboeck, University of Oxford • Professor Trevor Owens, University of Southern Denmark • Professor Giampietro Schiavo, London Research Institute, CRUK • Professor Lawrence Wilkinson, Cardiff University 8 Cognitive Neuroscience and Mental Health To improve understanding of how the brain functions at the cognitive level, and to find improved approaches for treating brain and mental health disorders. Its remit includes: • Systems-based research including cognition and behavioural neuroscience • Neurological disorders • Mental health disorders • Translational neuroscience including cognitive interventions • Genetics with detailed clinical phenotypic assessments Cognitive Neuroscience and Mental Health • Professor Dorothy Bishop (co-Chair), University of Oxford • Professor Roger Lemon (co-Chair), UCL • Professor Anke Ehlers, King's College London • Professor Derek Jones, Cardiff University • Professor Michael Morgan, City University of London • Professor Anna Christina Nobre, University of Oxford • Professor David Porteous, University of Edinburgh • Professor Edward Watkins, University of Exeter • Professor Simon Wessely, King's College London • Professor Daniel Wolpert, University of Cambridge 9 Genetics, Genomics and Population Research To improve understanding genetic variation in individuals and across populations. Its remit includes: • Studies of interactions between genes and environment • Bioinformatics and statistics as generic tools • Genetic/genome evolution • Population based genetics • Genetics in Health and Disease Genetics, Genomics and Population Research • Professor Andrew Morris (Chair), University of Dundee • Professor John Danesh (Deputy Chair), University of Cambridge • Dr Inês Barroso, Wellcome Trust Sanger Institute, Hinxton • Dr Ewan Birney, European Bioinformatics Institute, Hinxton • Professor George Davey Smith, University of Bristol • Professor Cathryn Lewis, Institute of Psychiatry, KCL • Professor James Lupski, Baylor College of Medicine, USA • Professor Gilean McVean, University of Oxford • Professor Nazneen Rahman, Institute of Cancer Research • Dr Camilla Stoltenberg, Norwegian Institute of Public Health, Olso 10 Immune System in Health and Disease To improve understanding of the immune system. Its remit includes: • Cellular and molecular immunology • Inflammation, allergy and auto-immunity • The immune response to infection • Immunity and disease susceptibility/resistance • Identification and early-stage development of vaccine candidates and adjuvants Immune System in Health and Disease • Professor Paul Lehner (Chair), University of Cambridge • Professor Tim Elliott (Deputy Chair), University of Southampton • Dr Berndt Arnold, German Cancer Research Centre, Heidelberg • Professor Paul Crocker, University of Dundee • Professor David Goldblatt, Institute of Child Health, UCL • Dr Jean Langhorne, MRC National Institute for Medical Research • Professor Fiona Powrie, University of Oxford • Dr Felix Randow, MRC Laboratory of Molecular Biology, Cambridge • Professor Alexander Rudensky, Memorial Sloan-Kettering Cancer Centre, New York, USA • Professor David Wraith, University of Bristol 11 Molecular Basis of Cell Function Focused on the structural, biophysical and biochemical properties of genes, chromosomes and proteins. Its remit includes: • The fundamentals of gene expression (alternative splicing, imprinting, methylation, transcription, translation, DNA repair and DNA replication) • Chromosome structure/biology and the
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