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Summer 2020 Re Visiting a Past Event
REINVENTING AMERICAN DEMOCRACY FOR THE 21ST CENTURY THE INTERSECTION OF DEMOCRACY & RELIGION A Nation in Crisis SUMMER 2020 RE VISITING A PAST EVENT Policy Perspectives on Police Use of Lethal Force As America reckons with its relationship to police violence, we are reminded that progress can be slow. It has been more than five years since the deaths of Michael Brown and Eric Garner. On February 4, 2015, the Academy convened a discussion at the University of California, Berkeley, led by Andrea Roth (Assistant Professor of Law, University of California, Berkeley School of Law) and Franklin Zimring (William G. Simon Professor of Law, University of California, Berkeley School of Law) about the hundreds of people who are killed each year by police, the racial disparity among the victims, and the incomplete data that make analyzing the problem so difficult. The conversation also covered the effectiveness of various avenues for police reform. To read the full transcript of this event (published in the Spring 2015 issue of the Bulletin) and hundreds of other Stated Meetings from the last twenty years, please visit amacad.org/bulletin. A video of this event and many others can be found at youtube.com/americanacad. For more information about Academy events, please visit www.amacad.org/events. SUMMER 2020 CONTENTS Features 16 Letters from Members Letters upon election are an Academy tradition. Letters of reflection are something new. 20 Online Discussions A series of virtual programs on topics related to the COVID-19 pandemic. CONTENTS 4 Our Work 4 Reinventing American Democracy for the 21st Century 9 New Issue of Dædalus Explores the Intersection of Democracy & Religion 12 A New Profile of Humanities Departments Members 25 Noteworthy 9 Departments 3 From the President 28 From the Archives ON THE COVER: Several hundred doctors, nurses, and medical professionals gathered on June 5, 2020, in St. -
Summaries of FY 2001 Activities Energy Biosciences
Summaries of FY 2001 Activities Energy Biosciences August 2002 ABSTRACTS OF PROJECTS SUPPORTED IN FY 2001 (NOTE: Dollar amounts are for a twelve-month period using FY 2001 funds unless otherwise stated) 1. U.S. Department of Agriculture Urbana, IL 61801 Biochemical and molecular analysis of a new control pathway in assimilate partitioning Daniel R. Bush, USDA-ARS and Department of Plant Biology, University of Illinois at Urbana- Champaign $72,666 (21 months) Plant leaves capture light energy from the sun and transform that energy into a useful form in the process called photosynthesis. The primary product of photosynthesis is sucrose. Generally, 50 to 80% of the sucrose synthesized is transported from the leaf to supply organic nutrients to many of the edible parts of the plant such as fruits, grains, and tubers. This resource allocation process is called assimilate partitioning and alterations in this system are known to significantly affect crop productivity. We recently discovered that sucrose plays a second vital role in assimilate partitioning by acting as a signal molecule that regulates the activity and gene expression of the proton-sucrose symporter that mediates long-distance sucrose transport. Research this year showed that symporter protein and transcripts turn-over with half-lives of about 2 hr and, therefore, sucrose transport activity and phloem loading are directly proportional to symporter transcription. Moreover, we showed that sucrose is a transcriptional regulator of symporter expression. We concluded from those results that sucrose-mediated transcriptional regulation of the sucrose symporter plays a key role in coordinating resource allocation in plants. 2. U. -
REPORTER No 6396 W E D N E S D Ay 23 S E P T E M B E R 2015 V O L C X Lv I N O 1
CAMBRIDGE UNIVERSITY REPORTER NO 6396 W ED N E S D AY 23 S EPTEMBER 2015 V OL CXLV I N O 1 CONTENTS Notices Notices by Faculty Boards, etc. Calendar 2 Natural Sciences Tripos, Part II (Biological Notice of a Discussion on Tuesday, 13 October and Biomedical Sciences), 2015–16 11 2015 2 Natural Sciences Tripos, Part III (Experimental Preacher at Mere’s Commemoration in 2016 2 and Theoretical Physics) and Master of Nomination of the Proctors and Deputy Advanced Studies in Physics, 2015–16 12 Proctors for 2015–16 2 Form and conduct of examinations, 2016 Annual Reports 2 Asian and Middle Eastern Studies Tripos, Examination results statistics 2 Part II, 2016: correction 13 Vacancies, appointments, etc. Obituaries Electors to the Professorship of Comparative Obituary Notices 14 Philology 3 Graces Electors to the Professorship of Immunology 3 Grace submitted to the Regent House on Electors to the Sir Patrick Sheehy 23 September 2015 14 Professorship of International Relations 3 Acta Electors to the Professorship of Medieval History 4 Approval of Grace submitted to the Regent Electors to the William Wyse Professorship of House on 29 July 2015 14 Social Anthropology 4 Vacancies in the University 4 End of the Official Part of the ‘Reporter’ Elections, appointments, reappointment, and College Notices grants of title 5 Elections 15 Awards, etc. Vacancies 16 Scholarships and Prizes, etc. awarded 7 Other Notices 17 Events, courses, etc. Notice by the University Bellringer 17 Announcement of lectures, seminars, etc. 8 External Notices Notices by the General Board University of Oxford 17 Regulations for the University Library 9 The Cambridge Humanities Research Grants Scheme 9 Regulations for examinations Classical Tripos, Part II 10 Modern and Medieval Languages Tripos, Part IB 10 Bachelor of Theology for Ministry 10 PLISUB HED BY AUTHORITY 2 CAMBRIDGE UNIVERSITY REPORTER 23 September 2015 NOTICES Calendar 1 October, Thursday. -
An Interview with Ewine Van Dishoeck
Issue 52 j October 2018 . Dear Colleagues, Welcome to the 5th anniversary edition of AstroPAH! What better way to cele- brate this festive occasion with you than with a show of lasers as featured on our cover. This year’s Nobel Prize in physics went to Arthur Ashkin, Gerard´ Mourou and Donna Strickland for their ground-breaking work in creating tools made of light. As the cover reveals, this has been of utmost importance to multiple fields amongst which astronomy and chemistry. Noteworthy is that Donna Strickland is the 3rd woman ever to win a Nobel Prize in physics (and the 1st in over 50 years). We would further like to celebrate our anniversary with a tribute to our Kavli-price winner Ewine van Dishoeck, who was awarded this ”Nobel-price for astronomy” for her ”combined contributions to observational, theoretical, and laboratory astrochemistry, elucidating the life cycle of interstellar clouds and the formation of stars and planets” Enjoy our interview with her in the In Focus. Of course our newsletter itself is also ’In Focus’ with some nice numbers from your feedback, showing our impact in the community. Thanks to all of you who responded to our survey! We will take your feedback into account to improve our newsletter and continue to keep you updated on the rich field of PAH-related research. We also thank everyone who has sent their paper abstracts to us, in this issue and all previous ones. Once again, our abstract section is full of interesting papers on the- oretical, experimental, and observational studies of astronomical PAHs and so much more. -
2019 Annual Report
BECKMAN CENTER 279 Campus Drive West Stanford, CA 94305 650.723.8423 Stanford University | Beckman Center 2019 Annual Report Annual 2019 | Beckman Center University Stanford beckman.stanford.edu 2019 ANNUAL REPORT ARNOLD AND MABEL BECKMAN CENTER FOR MOLECULAR AND GENETIC MEDICINE 30 Years of Innovation, Discovery, and Leadership in the Life Sciences CREDITS: Cover Design: Neil Murphy, Ghostdog Design Graphic Design: Jack Lem, AlphaGraphics Mountain View Photography: Justin Lewis Beckman Center Director Photo: Christine Baker, Lotus Pod Designs MESSAGE FROM THE DIRECTOR Dear Friends and Trustees, It has been 30 years since the Beckman Center for Molecular and Genetic Medicine at Stanford University School of Medicine opened its doors in 1989. The number of translational scientific discoveries and technological innovations derived from the center’s research labs over the course of the past three decades has been remarkable. Equally remarkable have been the number of scientific awards and honors, including Nobel prizes, received by Beckman faculty and the number of young scientists mentored by Beckman faculty who have gone on to prominent positions in academia, bio-technology and related fields. This year we include several featured articles on these accomplishments. In the field of translational medicine, these discoveries range from the causes of skin, bladder and other cancers, to the identification of human stem cells, from the design of new antifungals and antibiotics to the molecular underpinnings of autism, and from opioids for pain -
Science & Policy Meeting Jennifer Lippincott-Schwartz Science in The
SUMMER 2014 ISSUE 27 encounters page 9 Science in the desert EMBO | EMBL Anniversary Science & Policy Meeting pageS 2 – 3 ANNIVERSARY TH page 8 Interview Jennifer E M B O 50 Lippincott-Schwartz H ©NI Membership expansion EMBO News New funding for senior postdoctoral In perspective Georgina Ferry’s enlarges its membership into evolution, researchers. EMBO Advanced Fellowships book tells the story of the growth and ecology and neurosciences on the offer an additional two years of financial expansion of EMBO since 1964. occasion of its 50th anniversary. support to former and current EMBO Fellows. PAGES 4 – 6 PAGE 11 PAGES 16 www.embo.org HIGHLIGHTS FROM THE EMBO|EMBL ANNIVERSARY SCIENCE AND POLICY MEETING transmissible cancer: the Tasmanian devil facial Science meets policy and politics tumour disease and the canine transmissible venereal tumour. After a ceremony to unveil the 2014 marks the 50th anniversary of EMBO, the 45th anniversary of the ScienceTree (see box), an oak tree planted in soil European Molecular Biology Conference (EMBC), the organization of obtained from countries throughout the European member states who fund EMBO, and the 40th anniversary of the European Union to symbolize the importance of European integration, representatives from the govern- Molecular Biology Laboratory (EMBL). EMBO, EMBC, and EMBL recently ments of France, Luxembourg, Malta, Spain combined their efforts to put together a joint event at the EMBL Advanced and Switzerland took part in a panel discussion Training Centre in Heidelberg, Germany, on 2 and 3 July 2014. The moderated by Marja Makarow, Vice President for Research of the Academy of Finland. -
Immune Homeostasis
IMMUNE HOMEOSTASIS FUNDED PROJECTS FROM THE INNOVATION WORKSHOP 18-20 JULY 2017 AIMS THE SANDPIT PROCESS CAN BE BROKEN DOWN The immune system continues to intrigue and test us: as we get closer to finding ways of harnessing or modulating immune responses, new and unexpected consequences and INTO SEVERAL STAGES: challenges present themselves, often testing even our most fundamental understanding. Cancer Research UK and Arthritis Research UK came together to engage the research community to tackle the specific challenge of understanding how the immune system regulates itself under normal physiological conditions (immune homeostasis), how it is • Defining the scope of the challenge dysregulated in different diseases and how we can stimulate the immune response to prevent • Sharing understanding of the challenge and expertise brought to the sandpit by or treat disease (immunotherapy). participants We brought together researchers and clinicians in the fields of inflammatory disease, cancer, • Evolving common languages and terminologies amongst people from a diverse theoretical physics, computational medicine and other areas, whose expertise could be applied range of backgrounds and disciplines to the key questions concerning immune homeostasis. This workshop encouraged participants from a diverse range of backgrounds to melt barriers, develop a common language to promote • Breaking down preconceptions of researchers and stakeholders collaboration, and suggest new ways to harness the immune system to treat disease. • Taking part in break-out sessions focussed on challenges, using creative thinking techniques Director • Capturing outputs in the form of highly innovative feasibility study proposals The role of the Director was to work with the facilitators to lead the event and guide the process • A funding decision on those proposals at the sandpit, using “real time” peer-review. -
Plant Development Series Editor Paul M
VOLUME NINETY ONE CURRENT TOPICS IN DEVELOPMENTAL BIOLOGY Plant Development Series Editor Paul M. Wassarman Department of Developmental and Regenerative Biology Mount Sinai School of Medicine New York, NY 10029-6574 USA Olivier Pourquié Institut de Génétique et de Biologie Cellulaire et Moléculaire (IGBMC) Inserm U964, CNRS (UMR 7104) Université de Strasbourg Illkirch France Editorial Board Blanche Capel Duke University Medical Center Durham, NC, USA B. Denis Duboule Department of Zoology and Animal Biology NCCR ‘Frontiers in Genetics’ Geneva, Switzerland Anne Ephrussi European Molecular Biology Laboratory Heidelberg, Germany Janet Heasman Cincinnati Children’s Hospital Medical Center Department of Pediatrics Cincinnati, OH, USA Julian Lewis Vertebrate Development Laboratory Cancer Research UK London Research Institute London WC2A 3PX, UK Yoshiki Sasai Director of the Neurogenesis and Organogenesis Group RIKEN Center for Developmental Biology Chuo, Japan Philippe Soriano Department of Developmental and Regenerative Biology Mount Sinai Medical School New York, USA Cliff Tabin Harvard Medical School Department of Genetics Boston, MA, USA Founding Editors A. A. Moscona Alberto Monroy VOLUME NINETY ONE CURRENT TOPICS IN DEVELOPMENTAL BIOLOGY Plant Development Edited by MARJA C. P. TIMMERMANS Cold Spring Harbor Laboratory Cold Spring Harbor New York, USA AMSTERDAM • BOSTON • HEIDELBERG • LONDON NEW YORK • OXFORD • PARIS • SAN DIEGO SAN FRANCISCO • SINGAPORE • SYDNEY • TOKYO Academic Press is an imprint of Elsevier Academic Press is an imprint of Elsevier 525 B Street, Suite 1900, San Diego, CA 92101-4495, USA 30 Corporate Drive, Suite 400, Burlington, MA 01803, USA 32, Jamestown Road, London NW1 7BY, UK Linacre House, Jordan Hill, Oxford OX2 8DP, UK First edition 2010 Copyright Ó 2010 Elsevier Inc. -
The Roles of Atf3 in Stress-Regulated Signal Transduction
THE ROLES OF ATF3 IN STRESS-REGULATED SIGNAL TRANSDUCTION AND CELL DEATH IN PANCREATIC BETA-CELLS DISSERTATION Presented in Partial Fulfillment of the Requirements for the Degree Doctor of Philosophy in the Graduate School of The Ohio State University By Matthew G. Hartman, B.S. * * * * * The Ohio State University 2005 Dissertation Committee: Approved by Dr. Tsonwin Hai, Advisor Dr. Gary Kociba Advisor Dr. James DeWille Molecular, Cellular and Developmental Biology Program Dr. John Oberdick ABSTRACT Currently there are 20 million people diagnosed with diabetes in the United States and the incidence is expected to increase by 42% over the next twenty years. Type 1, or insulin-dependent diabetes, is an autoimmune disorder characterized by infiltration of activated T-lymphocytes into the pancreas. Auto- reactive immune cells initiate β-cell destruction by several mechanisms including secretion of soluble factors (cytokines), direct cell-cell contact, and activation of osmotic lysis signals. Type 2, or insulin-independent diabetes, is characterized by insulin resistance in the peripheral tissues such as the liver, fat, and skeletal muscle. Phosphorylation of key substrates involved in the insulin signal transduction pathway by stress-activated protein kinases contributes to the insulin resistance and prevents the uptake of glucose from the blood. Recent reports suggest that type 2 diabetes is a slower progressing form of type 1 and that β-cell apoptosis contributes to the pathogenesis of both forms. Activating Transcription Factor 3 (ATF3) is a member of the ATF/CREB family of transcription factors which regulate gene expression through their ability to bind a common DNA sequence motif (TGACGTCA). -
Born in Geneva in 1955) Is a Swiss-French Biologist
C.V. Prof Denis Duboule Denis Duboule ForMemRS (born in Geneva in 1955) is a Swiss-French biologist. He earned his PhD in Biology in 1984 and is currently Professor of Developmental Genetics and Genomics at the EPFL and at the department of Genetics and Evolution of the University of Geneva. Since 2001, he is also the Director of the Swiss National Research Center ‘Frontiers in Genetics’. He has notably worked on Hox genes, a group of genes involved in the formation of the body plan and of the limbs. Denis Duboule obtained a PhD from the University of Geneva in 1984. After questioning Karl Illmensee's claims of having cloned a mouse, Duboule departed to work as a postdoc and then a group leader at the University of Strasbourg, with Pierre Chambon. In 1988, he became a group leader at the European Molecular Biology Laboratory in Heidelberg, Germany. In 1992, he obtained a tenure at the Geneva University. From 1997, he has headed the Department of Genetics and Evolution (formerly Zoology and Animal Biology) Since 2001, he has also chaired the NCCR Frontiers in Genetics and, since 2006, he is a full professor at the EPFL. Denis Duboule has a longstanding interest in the function and regulation of Hox genes, a family of genes responsible for the organization and evolution of animal body plans. These genes have been a paradigm to understand embryonic patterning, in developmental, evolutionary and pathological contexts. Denis Duboule's contributions are thus in the field of vertebrate developmental genetics with some interface with medical genetics and evolutionary biology. -
Table of Contents (PDF)
September 25, 2018 u vol. 115 u no. 39 From the Cover 9714 Social networks and partisan bias E9153 mRNA-based cancer vaccine E9182 Gene therapy and muscular dystrophy 9672 Ion-conducting perovskite materials 9779 Arginine deprivation and tuberculosis Contents THIS WEEK IN PNAS 9641 In This Issue Cover image: Pictured is a cliff exposed by glacial retreat. Douglas Guilbeault et al. found that in bipartisan social LETTERS (ONLINE ONLY) networks, liberals’ and conservatives’ interpretations of data on Arctic sea ice E9026 Pitfall of big databases became more accurate and less biased Zhangqiang You, Junhua Hu, Qing Wei, Chunwang Li, Xiaofei Deng, and Zhigang Jiang upon exposure to each other’s opinions E9029 Reply to You et al.: The World Database on Protected Areas is an invaluable in the absence of political imagery. resource for global conservation assessments and planning However, such effects were not Paul R. Elsen, William B. Monahan, and Adina M. Merenlender observed when participants were exposed to each other’s opinions in the presence of political party logos. The OPINION—Leading scientists discuss current issues results suggest that exposure to 9642 Reconsidering bioenergy given the urgency of climate protection opposing views can reduce partisan bias John M. DeCicco and William H. Schlesinger in interpretation of climate data, but only in the absence of political cues. See the article by Guilbeault et al. on pages PROFILE 9714–9719. Image courtesy of Unsplash/ 9646 Profile of Yuval Peres Yiran Ding. Sandeep Ravindran See Inaugural Article on page 9666 COMMENTARIES 9649 More security may actually make us feel less secure Vesla M. -
From Telomeres to Empathy Highlights from the EMBO Meeting 2010 by CRISTINA JIMÉNEZ
AUTUMN 2010 encounters Newsletter of the European Molecular Biology Organization From telomeres to empathy Highlights from The EMBO Meeting 2010 BY CRISTINA JIMÉNEZ ◗ In the early 1980s, after a meeting at the Gordon Research Conference, Elizabeth Blackburn and Jack Szostak discovered that telo meres include a specifi c DNA sequence. 29 years on, the fortuitous encounter resulted in a Nobel Prize for discovering the structure Elizabeth Frans de Waal Blackburn of molecular caps called telomeres and for working out how they protect chromosomes from degradation. This is only one fi brillation, a condition in Richard example of how necessary meetings can be for the advancement of sci- which there is uncoordinated Losick ence. They provide a perfect setting for junior researchers to approach contraction of the cardiac prospective supervisors – and vice versa. They can lead to new part- muscle of the ventricles in the nerships between research groups working in similar fi elds. And they heart, making them quiver also inspire open discussion and collaboration between institutions. rather than contract properly. The EMBO Meeting, held in September in Barcelona, gathered more Haïssaguerre explained how than 1,300 researchers from a broad scope of disciplines, extending he is currently having great from synthetic, developmental and evolutionary biologists to plant success in curing hundreds of scientists and neuroscientists. “Postdocs and PhD students are the patients every year from this main benefi ciaries of these meetings,” pointed out Luis Serrano, who sort of arrhythmia. Austin co-organized the meeting with Denis Duboule. Smith, the other prize winner, | Barcelona © Christine Panagiotidis The meeting kicked off on Saturday 4 September with Richard Losick gave a lecture on stem cells and the Design principles of pluripotency.