0 1 0 2 Acknowledgements T

HFSPO is grateful for the support of the following organizations: O R

Australia R E P

National Health and Medical Research Council (NHMRC) L

Canada A Canadian Institute of Health Research (CIHR) Natural Sciences and Engineering Research Council (NSERC)

European Union N U European Commission - A Directorate General Information Society (DG INFSO) European Commission - Directorate General Research (DG RESEARCH)

France Communauté Urbaine de Strasbourg (CUS) Ministère des Affaires Etrangères et Européennes (MAEE) Ministère de l’Enseignement Supérieur et de la Recherche (MESR) Région Alsace

Germany Federal Ministry of Education and Research (BMBF)

India Department of Biotechnology (DBT), Ministry of Science and Technology

Italy Ministry of Education, University and Research (CNR)

Japan Ministry for Economy, Trade and Industry (METI) Ministry of Education, Culture, Sports, Science and Technology (MEXT)

Republic of Korea Ministry of Education, Science and Technology (MEST)

New Zealand Health Research Council (HRC)

Norway Research Council of Norway (RCN)

Switzerland State Secretariat for Education and Research (SER)

United Kingdom The International Human Frontier Science Biotechnology and Biological Sciences Research Program Organization (HFSPO) Council (BBSRC) 12 quai Saint Jean - BP 10034 Medical Research Council (MRC) 67080 Strasbourg CEDEX - Fax. +33 (0)3 88 32 88 97 United States of America e-mail: [email protected] National Institutes of Health (NIH) Web site: www.hfsp.org National Science Foundation (NSF) Japanese web site: http://jhfsp.jsf.or.jp HUMAN FRONTIER SCIENCE PROGRAM

The Human Frontier Science Program is unique, supporting international collaboration to undertake innovative, risky, basic research at the frontiers of the life sciences. Special emphasis is HFSPO given to the support and training of independent young Registre des Associations de Strasbourg investigators, beginning at the postdoctoral level. The Program is Volume 58- Folio 99 Achevé d’imprimé en juillet deux mille onze implemented by an international organisation, supported sur les presses de Faber financially by Australia, Canada, France, , India, Italy, Japan, the Republic of Korea, New Zealand, Norway, Switzerland, The International Human Frontier Science Program Organization (HFSPO) the United Kingdom, the United States of America, and the 12 quai Saint Jean European Union. Since 1990, nearly 6000 awards have been made BP 10034 to researchers from more than 70 countries. Of these, 16 HFSP 67080 Strasbourg CEDEX France awardees have gone on to receive the Nobel Prize. Fax. +33 (0)3 88 32 88 97 e-mail: [email protected] Web site: www.hfsp.org Japanese web site: http://jhfsp.jsf.or.jp

© Photos: HFSPO thanks Rae Silver, Frederick MacKintosh and Michael Elowitz for supplementary photos, in addition to those provided by Sandro Weltin (p. 7, 17, 27, 39, 53), Toru Nakahara (p.10), Musashi University (p. 12), BNP Paribas Real Estate (p.15), the Ravi Studio, Thiruvananthapuram (p. 9, 41) and those taken from the website of the Max Planck Institute of Molecular Cell and , Dresden (p. 25), iStockphoto (cover), iStockphoto (p.16), iStockphoto (p.26), shutterstock/ arteretum (p.6), shutterstock/ Michael Pettigrew (p.52), shutterstock/ Nancy Kennedy (p.68). 78143•HFSP-RA-2011-chap1_HFSP-RA-2011-chap1 15/06/11 16:06 Page3

APRIL 2010 - MARCH 2011 ANNUAL REPORT 78143•HFSP-RA-2011-chap1_HFSP-RA-2011-chap1 15/06/11 16:06 Page4

Table of contents

The following documents are available on the HFSP web site www.hfsp.org

Joint Communiqués (Tokyo 1992, Washington 1997, Berlin 2002, Bern 2004, Ottawa 2007, Canberra 2010): http://www.hfsp.org/about-us/governance/intergovernmental-conference Statutes of the International Human Frontier Science Program Organization: http://www.hfsp.org/about-us/governance/statutes Guidelines for the participation of new members in the HFSP: http://www.hfsp.org/about-us/new-membership General Reviews of the HFSP (1996, 2001, 2006-2007, 2010): http://www.hfsp.org/about-us/reviews-hfsp Updated and previous lists of awards, including titles and abstracts: http://www.hfsp.org/awardees 78143•HFSP-RA-2011-chap1_HFSP-RA-2011-chap1 15/06/11 16:06 Page5

INTRODUCTION 7 Introduction 8 Highlights in FY 2010 9 Message of the Secretary General 10 Board of Trustees 12 Council of Scientists 14 Secretariat 15

CHAPTER 1 - FELLOWSHIP PROGRAM 17 1.1 Introduction 18 1.2 Long-Term and Cross-Disciplinary Fellowships 18 1.3 Fellowship Awards in 2011 20 1.4 Short-Term Fellowships 22 1.5 Career Development Awards 23 1.6 Career Development Awards in 2011 24 1.7 The 2011 Review Committee for Fellowships 25

CHAPTER 2 - RESEARCH GRANT PROGRAM 27 2.1 Overview of the Grant Program 28 2.2 Young Investigator Grants 30 2.3 Program Grants 30 2.4 Research Grant Awards in 2011 31 2.5 The 2011 Review Committee for Research Grants 36

CHAPTER 3 - OUTREACH AND NETWORKING 39 3.1 HFSP Nakasone Award 40 3.2 Awardees Meeting 41 3.3 Communications 42 3.4 Alumni network 44 3.5 Honours and Prizes 45

CHAPTER 4 - BUDGET AND FINANCE 59 4.1 Guidelines for HFSPO funding 54 4.2 Key financial figures for FY 2010 54 4.3 FY 2010 financial summary 61 4.4 Budget for program activities FY 2011 63

APPENDIX 77 A.1 History of the Program 70 A.2 Joint Communiqué of the Intergovernmental Conference on the Human Frontier Science Program, Canberra, 28 May 2010 72 A.3 Summary of decisions of the Board of Trustees in 2010 74 A.4 Long-Term and Cross-Disciplinary Fellowships awarded in 2010 75 A.5 Short-Term Fellowships awarded in 2010 77 A.6 Career Development Awards made in 2010 78 A.7 Research Grants awarded in 2010 79 78143•HFSP-RA-2011-chap1_HFSP-RA-2011-chap1 15/06/11 16:07 Page6

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Introduction

Introduction

Highlights in FY 2010 Message of the Secretary General Board of Trustees Council of Scientists Secretariat

Ernst-Ludwig WINNACKER (Secretary General), Toru NAKAHARA (Deputy Secretary General), Front: Jill HUSSER

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Introduction Since 1990, 865 Research Grants involving 3,279 scientists, 2,520 Long-Term, 68 Cross-Disciplinary Fellowships and 164 Career Development Awards have been awarded. Researchers from more than 70 countries have received HFSP funding so far.

The focus of research supported by HFSP is on the complex mechanisms of living organisms, ranging from the biomolecular level to that of behaving organisms. The life sciences have undergone a revolution in recent years, emerging as a leading The Human Frontier Science Program (HFSP) scientific area with a convergence of interest from promotes fundamental research in the life other disciplines such as physics, mathematics, sciences with special emphasis on novel and , computer science and engineering on interdisciplinary research, international and in solving biological questions. HFSP aims to stay at the particular intercontinental collaboration and forefront of research by involving scientists from support for young investigators. Since its outside the life sciences as part of research establishment in 1989, HFSP has demonstrated collaborations and as postdoctoral fellows. To this end, the value of creating a framework for the Young Investigator and Program Grants are competitive, collaborative, international research specifically geared to fostering interactions between scientists from different disciplines and this is a major of the highest caliber and of providing young factor in the review of applications in these programs. scientists with the opportunity to emerge as In addition, HFSP has extended its commitment talented researchers capable of shaping the to interdisciplinary research by introducing science of the future. Cross-Disciplinary Fellowships to equip young scientists from outside biology with the skills needed The International Human Frontier Science Program to tackle problems in the life sciences. Organization (HFSPO) implements the Program through the following mechanisms of research A program dedicated to the frontiers of science must support, details of which can be found in Chapters 1 support the next generation of researchers, who are in and 2 of this report: the strongest position to open new avenues of research. Several of the HFSP programs are specifically ■ Long-Term Fellowships – for young scientists within targeted towards early career scientists: the Fellowship three years of obtaining their PhD who wish to programs, Career Development Award and Young broaden their scientific experience in a foreign Investigator Grants. In addition, Program Grant teams laboratory. are encouraged to include young scientists with the result that a significant number of scientists under ■ Cross-Disciplinary Fellowships – modeled on the the age of 40 participate in this program. Taking these Long-Term Fellowships but specifically for scientists researchers together, approximately 70% of annual with Ph.Ds in non-biological disciplines who seek HFSP funds are awarded to early career researchers. training in the life sciences. The HFSPO is governed by a Board of Trustees (Board) ■ Career Development Awards – for former HFSP consisting of representatives of the MSPs. The Board Fellows to help them set up their own independent is advised by a scientific advisory body, the Council laboratories in the home country. of Scientists (Council) and the Organization is run from the Secretariat in Strasbourg, France. ■ Young Investigator Grants – grants for interdisciplinary teams of young researchers who are within the first five years of their first independent positions and The HFSPO is financed and managed by located in different countries. representatives of the Management Supporting Parties (MSPs). The MSPs are those countries that ■ Program Grants – for interdisciplinary teams of directly fund the HFSP Programs plus the European researchers in different countries at any stage of Union, which represents the EU countries that do their career. not contribute directly. The MSPs are: Australia, Canada, France, Germany, India, Italy, Japan, the Republic of Korea, New Zealand, Norway, Switzerland, the United Kingdom, the United States of America and the European Union. Japan provided about 49.3% of MSPs’ contributions for FY 2010.

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Highlights in FY 2010

Karl DEISSEROTH receives the 2010 Nakasone Award from President Akito ARIMA

● The 6th Intergovernmental Conference was held on 28 May in Canberra, Australia.

● The HFSP alumni network was launched with two inaugural meetings, one in Montreal, Canada, on 29 July and the other in Tokyo, Japan, on 9 October.

● The new web site was launched in February 2011.

● The recipient of the HFSP Nakasone Award 2010 was , , USA. ● The recipient of the HFSP Nakasone Award 2011 is Michael ELOWITZ, California Institute of Technology, USA.

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Message from the Secretary General

THE ‘RAISON D’ÊTRE’ OF HFSP

It is of crucial importance for any funding agency to challenge its raison-d’être, especially in times of financial exertion. What then is the unique spirit of HFSP? Where exactly is the special niche of HFSP in the plethora of research funding agencies? What is so special about HFSP?

The international character of HFSP One of its unique assets is the international and more often intercontinental character of its programs. HFSP funds program grants composed of teams of two to four scientists, independent of where they are located in the world, as long as the PI is from one of the 13 participating member countries plus the EU. There is no necessity for multilateral agreements between different funding agencies or governments. The HFSP Ernst-Ludwig WINNACKER, concept is much in line with a recent study of the Secretary General of HFSPO Royal Society on global scientific collaborations, which strongly argues for strengthening support for international science. It “warns governments against viewing multinational research efforts as “easy targets” for spending cuts during tight fiscal times. This could isolate national science activities, threatening quality and impact” (Nature 471, 559 (2011).

The spirit of Canberra The contributions of participating MSPs to HFSP’s budget are voluntary. Every three years an Intergovernmental Conference (IGC) sets the budget of HFSP for the next three years. At the last IGC in May 2010 in Canberra, the representatives of all member countries except France and Japan (which remains by far the major contributor) promised an increase in their HFSP contributions of 4% per year for 2011-2013. During the discussions, it became clear that the policies of HFSP and its efforts to fund the frontiers of the life sciences are highly appreciated. We are most grateful to members of the Board and their respective governments or agency directors for their generous support of HFSP even though the financial crisis has reached all of them.

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Financial challenges HFSP tries to be at the heart of these developments. Support from France diminished with the loss of the It has long fostered interdisciplinarity but has realized contribution of the Ministry of Foreign Affairs (about that interdisciplinarity alone is not sufficient as the 900,000 EUR) while the contributions from the cornerstone of its funding policy even if it can create Ministry of Higher Education and Research, the City of added value. We therefore advise our review Strasbourg and the Region of Alsace were kept committees to focus on innovative frontier research, constant or were even slightly increased. We hope which implies a need to take risks. Though risk-taking and expect that the missing portion from France will entails the possibility of failure, such approaches may be compensated for by contributions from other also pay off handsomely. Let us not forget that HFSP ministries and that France, as host country of the has funded 16 Nobel Prize winners in the past, long Secretariat of HFSP, will soon return to the level of its before they were awarded this unique distinction. The original commitment. list of winners of other prizes, as documented in this report, demonstrates the distinguished nature of our For FY 2011, Japan’s contribution will be reduced by grantees. Thus, we hope to continue in the tradition of 4.75 million USD. This will bring the Japanese excellence, which has served the scientific community contribution to around 44% of 2011 contributions. and HFSP so well in the past, building on the recent The reduction has to be seen in the context of the developments of modern biology. enormous and unique contribution of Japan to the Program from its beginnings. Japan has contributed I am grateful to our supporters, the members of our around 720 million USD to HFSP over the last 21 years, review committees, the numerous mail reviewers and as compared to approximately 373 million USD from the members of our small office in Strasbourg who all other participating member countries together. work unremittingly and with utmost diligence, Should this proportion decrease over the next decade, devotion and professionalism. Japan expects a progressive increase in contribution from the other participating countries to permit HFSP to fulfill its mission. It is important to dwell on these financial issues since the Program as such is in high demand and since its success rates have already reached a lower limit.

Support of frontier research A strong and important asset of HFSP is its focus on frontier research. Since its establishment, HFSP has directed its funding efforts to “complex mechanisms of living organisms”. This proposal by former Japanese Prime Minister Nakasone, which was later refined, appears extremely farsighted. A quarter of a century ago when HFSP was conceived, the recombinant DNA debate was already rampant both in the US and in Europe. Nevertheless it was hard to predict how it would change the course of biology. After a long Cinderella-type existence, biology has now moved into center stage, with the computer-sciences, engineering, mathematics and other natural sciences converging into it to finally make biology quantitative.

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Board of Trustees

Akito ARIMA, President of HFSPO

President Akito ARIMA, Musashi Gakuen, Tokyo, Japan

Vice-Presidents Isabella BERETTA, State Secretariat for Education and Research, Switzerland Kathie OLSEN, National Science Foundation, USA

Australia Warwick ANDERSON, National Health and Medical Research Council Emmanuel PAPADAKIS, National Health and Medical Research Council

Canada Pierre CHARTRAND, Canadian Institutes of Health Research (until February 2011) Danielle MÉNARD, Natural Sciences and Engineering Research Council Kelly VANKOUGHNET, Canadian Institutes of Health Research (from February 2011)

France Jacques DEMOTES-MAINARD, Ministère de l’Enseignement Supérieur et de la Recherche (from November 2010) Fatima OUALI, Ministère des Affaires Etrangères et Européennes (until March 2011) Raymond PAMPHILE, Ministère de l’Enseignement Supérieur et de la Recherche (until November 2010)

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Germany United Kingdom Frank LAPLACE, Federal Ministry of Education and Janet ALLEN, Biotechnology and Biological Sciences Research (from November 2010) Research Council Ingrid OHLERT, Deutsche Forschungsgemeinschaft Mark PALMER, Medical Research Council Ulrich SCHLÜTER, BMBF, Forschungszentrum Jülich (until October 2010) United States of America Kathie OLSEN, National Science Foundation India (until May 2010) Avadhesha SUROLIA, National Institute of Sally ROCKEY, National Institutes of Health Immunology Joann ROSKOSKI, National Science Foundation Krishnaswamy VIJAYRAGHAVAN, National Centre for (from August 2010) Biological Sciences European Union Italy Wolfgang BOCH, Information Society and Media Piergiorgio STRATA, National Institute of Directorate-General, European Commission Ruxandra DRAGHIA AKLI, Directorate-General Glauco TOCCHINI-VALENTINI, National Research Research, European Commission Council Auditors Japan Patrick PIERRAT, KPMG-SEGEC, France Akito ARIMA, Musashi Gakuen, Tokyo Akira HOSAKA, Ministry of Economy, Trade and Nobutaka HIROKAWA, University of Tokyo Industry (METI), Japan Meredith STEIN, National Institutes of Health, USA Republic of Korea Un-Woo LEE, Ministry of Education, Science and Technology (until May 2010) Ki Dong SONG, Ministry of Education, Science and Technology (from May 2010 until March 2011) Seong-Geun BAE, Ministry of Education, Science and Technology (from March 2011) Yoo-Hun SUH, Seoul National University

New Zealand Graeme FRASER, Health Research Council for New Zealand

Norway Dag AKSNES, University of Bergen (until December 2010) Rein AASLAND, University of Bergen (from January 2011)

Switzerland Isabella BERETTA, State Secretariat for Education and Research Pierre MAGISTRETTI, Ecole Polytechnique Fédérale de Lausanne and Lausanne University

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Australia Suzanne CORY, The Walter and Eliza Hall Institute of Medical Research, Parkville

Canada Leah KESHET, University of British Columbia, Vancouver

France Council of Scientists , Institut Pasteur, Paris Germany Hans-Georg RAMMENSEE, Eberhard-Karls-University, Tübingen

India Madan RAO, Raman Research Institute and National Centre for Biological Sciences, Bangalore Satyajit RATH, National Institute of Immunology, New Delhi

Italy Salvatore OLIVIERO, Department of , University of Siena

Japan Rae SILVER, Chair of the Council of Scientists Shuh NARUMIYA, University of Kyoto

Republic of Korea Young-Joon KIM, Yonsei Institute, Seoul

Chair: New Zealand Rae SILVER, , New York USA Kenneth McNATTY, Victoria University of Wellington

Vice-Chair Norway Young-Joon KIM, Yonsei Genome Institute, Seoul, Svein DAHL, University of Tromsø Republic of Korea Switzerland Pico CARONI, Friedrich Miescher Institute for Biomedical Research, Basel

United Kingdom Judith ARMITAGE,

United States of America Rae SILVER, Columbia University, New York Susan TAYLOR, University of California, San Diego

European Union Sten GRILLNER, Karolinska Institute, Stockholm

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Secretariat

12 quai Saint Jean, Strasbourg (France)

\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\ \\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\ Executive Office Administration and Finance Ernst-Ludwig WINNACKER (Germany), Secretary Isabelle HEIDT-COQUARD (France), Manager General Sarah NAETT CAZAU (New Zealand), Assistant Toru NAKAHARA (Japan), Deputy Secretary General Jennifer SAYOL (France), Assistant Jill HUSSER (UK), Assistant \\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\ \\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\ IT Systems Scientific Affairs and Communications Xavier SCHNEIDER (France), Manager Martin REDDINGTON (UK), Director Rosalyn HUIE (UK), Assistant \\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\ Administrative Officer \\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\ Akihiko TANAKA (Japan), from May 2010 Research Grants Geoffrey RICHARDS (UK), Director Carole ASNAGHI (France), Assistant Armelle KOUKOUI (Bénin), Assistant

\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\ Fellowships Guntram BAUER (Germany), Director Marie-Claude PERDIGUES (France), Assistant Carine SCHMITT (France), Assistant

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Chapter 1

Fellowship Program

1.1 Introduction 1.2 Long-Term and Cross-Disciplinary Fellowships 1.3 Fellowship Awards in 2011 1.4 Short-Term Fellowships 1.5 Career Development Awards 1.6 Career Development Awards in 2011 1.7 The 2011 Review Committee for Fellowships Left to right: Marie-Claude PERDIGUES, Guntram BAUER and Carine SCHMITT

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1.1 1.2

INTRODUCTION LONG-TERM AND CROSS-DISCIPLINARY FELLOWSHIPS

The Fellowship Program provides postdoctoral Long-Term Fellowships are intended to encourage training opportunities for talented young young researchers with a background in the life scientists in the world's best laboratories and at sciences to seek additional research expertise and the same time facilitates the mobility of young training in other fields within biology. Applicants who propose a significant change in research direction and scientists between countries. With the increased whose research project is original and represents a complexity of science and scientific methodology, departure from their Ph.D work or previous research the process of learning new approaches requires are particularly encouraged. Statistics for this program longer periods of research experience before are shown in Fig. 1-1. independence can be achieved by the young investigator. Applicants for HFSP Fellowships are Cross-Disciplinary Fellowships are intended for encouraged to seek training in new fields in order postdoctoral fellows with a Ph.D degree in the physical to broaden their scientific experience. Upon sciences, chemistry, mathematics, engineering, completion of the fellowship, these well-trained computer sciences etc. who wish to receive training in the life sciences. The first awards in this category scientists are expected to be able to promote were made in 2005 and since then the applications for truly frontier research in the life sciences. this program have accounted for about 7-10% of annual fellowship submissions (Table 1-1). Applicants Initial postdoctoral support from HFSP funds three for this program are encouraged to propose a years of research in a new country. The option to significant change in discipline (e.g. from physics to defer the third fellowship year offers maximum cell biology) but should demonstrate how their specific flexibility at a critical stage of career advancement. expertise will bear on the biological question under A follow-up mechanism allows HFSP fellows to study and how the host laboratory will benefit from establish their own independent laboratories by their particular skills. means of the HFSP Career Development Award. The program mainly attracts applicants from chemistry and physics. Applications from engineers, biophysicists, mathematicians and computer scientists are also regularly submitted. This range of expertise is exceptional for a fellowship program that supports research in fundamental biological research. The broad acceptance of the Cross-Disciplinary Fellowships outside the life sciences shows that HFSP’s aim to provide a bridge across disciplinary boundaries is indeed being fulfilled.

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Awardees in both programs are required to be within Table 1-1: three years of receiving their Ph.D at the time of Annual number of reviewed fellowship application. They are expected to have at least one applications and awards (numbers for award year first author publication and must not have worked in 2011 may still be subject to change). the host institution for more than 12 months at the Long-Term Fellowships (since 2002) start of their fellowship. Award Number of Success Female awardees Fellows in both programs receive identical support year applications awards rate (%) Number % for three years, and those who wish to extend their 2002 567 94 17 27 29 research training have the possibility of deferring the 2003 639 90 14 29 32 2004 673 90 13 29 32 start of their third year for up to two years while being 2005 609 89 15 22 25 supported through other funding sources. The third 2006 629 83 13 29 35 and final year of support can either be used in the 2007 614 95 15 32 34 host laboratory or for a final year of postdoctoral 2008 580 89 15 32 36 training in a laboratory in the home country. The 2009 633 109 17 39 36 fellowship provides an annual stipend and a research 2010 592 75 13 32 43 and travel allowance. HFSP fellows with children also 2011 699 76 11 18 24 qualify for a child allowance. TOTAL 6235 890 14 289 32

The lists of Long-Term and Cross-Disciplinary Fellows Cross-Disciplinary Fellowships (since 2005) who started their project in FY 2010 are given in Appendix 4. Award Number of Success Female awardees year applications awards rate (%) Number % 2005 65 12 18 1 8 Fig. 1-1: 2006 55 10 18 2 20 Long-Term Fellowship applications, awards and 2007 54 5 9 0 0 success rates (1990-2011) 2008 56 11 20 1 9 2009 39 10 26 2 20 2010 55 11 20 1 9 2011 63 9 14 2 22 TOTAL 387 68 18 9 13

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1.3

FELLOWSHIP AWARDS

IN 2011 Fig. 1-2: Host country distribution of Long-Term and Cross-Disciplinary Fellowship awardees for FY 2011 as decided by the Board in March 2011

At its meeting in March 2011, the Board recommended 85 awards for the coming fiscal year. Of the 762 applications for award year 2011, 37 % of the applications were made by female candidates. Table 1-2 gives an overview of the distribution of the 2011 applicants and fellows according to their nationality and Fig. 1-2 an overview of the distribution of the 2011 awardees according to their host country. The call for applications is announced annually in major scientific journals and through the HFSP web site. The deadline for the electronic submission of fellowship applications was 9 September 2010. All applications were screened by the Secretariat for compliance with formal criteria and with the scientific scope of the Program.

Each application was assigned to two members of the Review Committee for a first evaluation during which the committee members each ranked around 50-60 applications. Some applications for which the expertise was not available within the Review Committee were also sent to external mail reviewers. The Secretariat then ranked the applications on the basis of this evaluation. In the discussions during the Review Committee meeting on 17-19 January 2011, the top applications were scored again by the entire committee and the most highly qualified candidates were recommended for funding.

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Table 1.2: Nationality of Long-Term (LTF) and Cross-Disciplinary Fellowship (CDF) applicants and awardees for FY 2011

Total Total LTF LTF CDF CDF Nationality applicants awardees applicants awardees applicants awardees

Australia 17 1 17 1 0 0 Canada 18 2 18 2 0 0 EU 163 18 148 (a) 18 (a’) 15 (c) 0 France 109 9 102 8 7 1 Germany 55 11 51 10 4 1 India 24 2 21 0 3 2 Italy 36 4 35 4 1 0 Japan 49 8 48 8 1 0 Korea938211 New Zealand 4 0 4 0 0 0 Norway000000 Switzerland 6 1 6 1 0 0 UK2302102 0 USA 44 5 38 5 6 0 Others 205 21 182 (b) 17 (b’) 23 (d) 4 (d’) TOTAL 762 85 699 76 63 9

Long-Term Fellowship applicants: Cross-Disciplinary Fellowship applicants: (a) EU: (c) EU: 5 Austria, 9 Belgium, 2 Bulgaria, 1 Czech Republic, 1 Austria, 1 Estonia, 1 Lithuania, 1 Netherlands, 3 Estonia, 4 Finland, 9 Greece, 6 Hungary, 5 Ireland, 3 Poland, 3 Portugal, 1 Romania, 4 Spain 14 Netherlands, 11 Poland, 11 Portugal, 3 Romania, (d) Others: 56 Spain, 9 Sweden 1 Argentina, 1 Belarus, 1 Cameroon, 2 China, 7 Israel, (b) Others: 1 Madagascar, 2 Malaysia, 1 Mexico, 1 Philippines, 1 Algeria, 16 Argentina, 1 Bangladesh, 6 , 1 Russia, 5 dual nationality 1 Cameroon, 4 Chile, 17 China, 4 Taiwan, 1 Colombia, 4 Croatia, 1 Egypt, 1 Ethiopia, 3 Iran, 42 Israel, 1 Macedonia, 1 Malaysia, 7 Mexico, 1 Pakistan, 1 Peru, 1 Philippines, 4 Russia, 1 Serbia, 4 Singapore, 1 South Africa, 1 Sri Lanka, 1 Thailand, 8 Turkey, 3 Ukraine, 1 Venezuela, 1 Vietnam, 43 dual nationality

Long-Term Fellowship awardees: Cross-Disciplinary Fellowship awardees: (a’) EU: (d’) Others: 1 Austria, 1 Greece, 5 Netherlands, 2 Poland, 2 Portugal, 2 Israel, 1 Iran/USA, 1 Switzerland/USA 6 Spain, 1 Sweden (b’) Others: 2 China, 2 Taiwan, 5 Israel, 2 Mexico, 1 Thailand, 1 Canada/Poland, 1 France/Germany, 1 Israel/USA, 1 Italy/USA, 1 Lebanon/Switzerland

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1.4

Fig. 1-3: SHORT-TERM Short-Term Fellowship applicants, awardees and FELLOWSHIPS success rate from the same fiscal year (1994-2009).

The Short-Term Fellowship program enabled researchers early in their career to spend two weeks to three months working in a laboratory in another country to learn new techniques or establish new collaborations. The Board decided not to accept any further Short-Term Fellowship applications as of 1 April 2010.

Before the program was discontinued, Short-Term Fellowship applications were accepted throughout the year. Thus, it was possible to apply in one fiscal year but be awarded the fellowship and be paid in the following fiscal year (in the case of a submission at the end of the fiscal year).

A list of the applicants who applied in FY 2009 and who were awarded the Short-Term Fellowship in FY 2010 is given in Appendix 5.

The number of applications received during each fiscal year since 1994 and the number of awards made among these applications is shown in Fig. 1-3. The figure also indicates the success rate for this program. The average female success rate is 37%.

In fiscal years 1990 to 1993, a total of 89 Short-Term Fellowships were awarded. The exact number of eligible applications is not available for this period, since in 1989 and 1990 only awardees were registered in the database.

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1.5

The first Career Development Awards were made in CAREER March 2003. Reviews have been conducted by the Council. Since the inception of this award, DEVELOPMENT 402 applications from 29 different countries have been submitted and 164 young scientists have received the AWARDS award. Each year this network expands as more and more fellows seek to establish their independent laboratories (Table 1-3). The list of award recipients It is often difficult for young investigators to obtain for FY 2010 is given in Appendix 6. independent funding to pursue their own line of research early in their career. To this end, HFSPO initiated the Career Development Award which facilitates the fellow’s transition from postdoctoral Table 1-3: researcher to independent scientist, providing further CDA applications and awards since the beginning of the program prospects for becoming an established investigator in the home country. The support helps young Award Number of Success Female awardees investigators develop their own research programs, year applications awards rate (%) Number % thus building a global culture of independent young 2003 22 8 36 researchers who are open to new ideas and 2004 41 17 41 5 29 international collaboration. 2005 47 18 38 2 11 2006 51 29 57 6 21 The objective of the award is to enable former 2007 48 24 50 6 25 2008 57 20 37 5 25 Long-Term or Cross-Disciplinary Fellows to establish 2009 49 24 49 2 8 their own independent research teams after return 2010 47 16 34 2 13 to the home country. Awardees have the opportunity 2011 40 8 20 1 13 to intensify their international collaborations and TOTAL 402 164 41 29 18 experimental endeavors on emerging subjects in the life sciences by drawing on their experience during their HFSP fellowship. Unlike fellowship stipends that are awarded to outstanding candidates to carry out a specific project, this award is meant to support the initiation of an independent research program that builds on the accomplishments of the fellowship tenure but also includes new elements of inter- national collaboration.

The Career Development Award provides 300,000 USD of support over three years and is open only to former HFSP Fellows who have completed at least two years of tenure in the host laboratory. Applicants must either be in the process of obtaining or already hold a position in the home country in which they are able to conduct independent research.

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1.6

CAREER Current fellows receive the information about the call DEVELOPMENT for applications by email. By the deadline on 14 October 2010, a total of 40 applications were AWARDS IN 2011 received. Former fellows from award years 2004-2008 were eligible to apply. Applications were assigned for review to all members of the Council who ranked and commented according to the selection criteria set out in the application guidelines. Each application was also sent to at least two external mail reviewers who were asked to provide written comments. After initial ranking by the Council members and further discussions during the meeting on 3-4 March 2011, 8 applications were recommended for funding. These were approved by the Board.

Fig. 1-4: Distribution of nationalities of CDA awardees for FY 2011

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France Marie-Anne FELIX, Université Paris Diderot Ludger JOHANNES, Institut Curie, Paris 1.7 Christophe MULLE, Université de Bordeaux 2

Germany Suzanne EATON, Max Planck Institute of Molecular Cell Biology and Genetics, Dresden Jörg ENDERLEIN, Georg August University, Göttingen Jane PARKER, Max-Planck Institute of Breeding Research, Cologne

India THE 2011 Vijayalakshmi RAVINDRANATH, Indian Institute of REVIEW COMMITTEE Science, Bangalore Italy FOR FELLOWSHIPS Diego DI BERNARDO, Telethon Institute of Genetics and Medicine, Naples

Japan Hiroyuki NAKAHARA, RIKEN Brain Science Institute, Saitama Osamu NUREKI, Tokyo Institute of Technology, Kanagawa

Republic of Korea Ildoo HWANG, Pohang University of Science and Technology Narry KIM, Seoul National University

New Zealand Nigel BIRCH, University of Auckland

Suzanne EATON, Chair of the Norway Fellowship Review Committee Finn-Eirik JOHANSEN, University of Oslo

Switzerland Jean PIETERS, University of Basel Ariel RUIZ I ALTABA, University of Geneva Chair Suzanne EATON, Max Planck Institute of Molecular United Kingdom Cell Biology and Genetics, Dresden, Germany , , University of Bath Vice-Chair Georges LACAUD, University of Manchester Ludger JOHANNES, Institut Curie, Paris, France

United States of America Australia Cecilia CLEMENTI, Rice University, Houston Kum Kum KHANNA, The Queensland Institute of Medical Research, Brisbane Barbara FINLAY, Cornell University, Ithaca

Canada Other David DANKORT, McGill University, Montreal Orly REINER, Weizmann Institute of Science, Rehovot, Israel European Union Wanjin HONG, National University of Singapore Felix RITORT, University of Barcelona, Spain Isabelle VERNOS, Centre for Genomic Regulation, Delegate of the Council of Scientists Barcelona, Spain Judith ARMITAGE, University of Oxford, UK

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Chapter 2

Research Grant Program

2.1 Overview of the Grant Program 2.2 Young Investigator Grants 2.3 Program Grants 2.4 Research Grant Awards in 2011 2.5 The 2011 Review Committee for Research Grants

Left to right: Geoffrey RICHARDS, Armelle KOUKOUI and Carole ASNAGHI

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2.1

the Research Grant Review Committee in OVERVIEW January examines and ranks each category OF THE separately. GRANT PROGRAM The moving frontiers The biggest challenge for the Review Committee is to identify novel frontier research applications often incorporating diverse expertise from both the Research Grants are awarded for innovative biological and physical sciences. For this the collaborative projects of fundamental biological Committee must include members familiar with research carried out by an international, and disciplines such as chemistry, physics, mathematics preferably intercontinental, team of two to four and engineering in addition to the more traditional biological sciences. The range of applications is such scientists having their laboratories in different that the Committee may lack the expertise necessary countries. Somewhat rarely a team is selected to assess the contribution of some of the team with five members, but the majority of larger members. In these cases we solicit opinions from mail teams have a weak link or show a redundancy reviewers working in departments that may be in expertise so that the overall research plan is unfamiliar with the Program. Fortunately, not only do not convincing. Grants are awarded for a period we observe the same willingness to help in the review of three years to teams who propose to combine process from such experts as those in more traditional their expertise to approach problems in the life biological departments, but also we often receive sciences that could not be answered by individual spontaneous remarks confirming the originality and interest of the project. However these same specialist laboratories. Emphasis is placed on the innovative reviewers sometimes point out that the ‘innovative’ nature of the collaboration often involving novel approach is routine in their discipline and that combinations of expertise. Particular attention furthermore the applicant’s grasp of the approach is is given to collaborations that bring together superficial. scientists from different disciplines (e.g. biology, chemistry, physics, mathematics, computer The concept of novelty is related to the development science and engineering). Applicants are expected of certain fields or techniques. A novel technology to develop new lines of research, rather than (microscopy, protein labelling, transgenic models, continue their ongoing program, and so as to computational programs etc.) may become widely available within two or three years of its first encourage novel ideas and innovative appearance in the HFSP competition and will start to approaches, preliminary results are not required. appear as a tool in a large number of applications. The Principal Applicant’s laboratory must be Similarly a project considered cutting-edge one year located in one of the member countries while may be considered as routine a couple of years later. the other team members may be situated In fact, in the absence of technological breakthroughs, anywhere in the world. fields can appear to stagnate for a year or two while teams concentrate on exploiting the last wave of There are two categories of grant: Young innovation. This may well be high quality science Investigator Grants for groups of young scientists destined for major journals, but the Committee members must have sufficient stature so as to decide establishing their research groups, and Program whether an approach has become standard or is truly Grants for scientists at any stage of their careers. innovative. The applications are processed in parallel but

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We have observed a growing willingness to collaborate effectively. While teams now have every opportunity to exchange on a daily basis via the web, despite this ease of communication, successful teams seem increasingly inclined to organize regular meetings to discuss problems face to face, or to visit each others’ laboratories for a few weeks so as to understand the scope of their partners contributions. The overall impression is that scientists are learning the interest of making such collaborations reality (rather than continuing their ongoing projects in parallel). This aspect is considered very seriously by the Review Committee which gives considerable importance to the details of interactions between the team members that are presented in the full application. With the expansion of HFSP membership in recent years the possible combinations have increased considerably (notably because of the role of the Principal Applicant in choosing team members) and we are seeing changes in the profiles of collaborations.

Interdisciplinarity in research grants Since 2001 HFSP has emphasized the importance of interdisciplinarity in the grants program. The 2008 Review Committee asked for more freedom in weighting the innovative, international and interdisciplinary components when assessing applications and this has been implemented since. In 2009, this change resulted in the reduction in the percentage of scientists coming from institutes outside the life sciences to about 19% in the awarded category and was a close match between ‘input’ and ‘output’ and this situation has been maintained in both the 2010 and 2011 cycles. This appears to represent an equilibrium point for the program and although interdisciplinarity will continue to be followed, it will no longer be featured as a separate item in the annual report.

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2.2 2.3

YOUNG INVESTIGATOR PROGRAM GRANTS GRANTS

The Young Investigator Grant scheme was introduced These are awarded to teams of independent in the 2001 award year to encourage collaboration researchers at any stage of their careers. The research between young scientists who are within five years team is expected to develop new lines of research of obtaining their first independent positions. Young through the collaboration. Applications including Investigator Grant teams receive 250 thousand USD independent investigators early in their careers are per year for two members, 350 thousand USD for three encouraged. Priority is given to new, innovative members, and 450 thousand USD for four or more. research projects for which preliminary results may Local collaborations in the same country are permitted not necessarily be available. Funding is based on team but teams only receive funds equivalent to 1.5 team size and is the same as for the Young Investigators members and then only if the collaboration is truly including the rules concerning team members from interdisciplinary. This measure aims to facilitate the the same country. The quality of applications in this formation of teams involving scientists from different competition has been boosted by the arrival of a disciplines since it is often difficult for scientists, cohort of younger investigators more familiar with especially younger investigators, to find appropriate interdisciplinary research, many of who have now partners internationally. In the 2011 award year, established their laboratories more than five years applications from Young Investigators represented ago and are no longer eligible for the Young about 21% of the letters of intent received. While in Investigator competition. 2009 and 2010 these applications had a similar success rate to those submitted for Program Grants they were somewhat more successful in 2011 and represented 33% of the final awards.

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2.4

RESEARCH GRANT AWARDS IN 2011

Awardees starting their research work in FY 2011 were selected among the applications received in reply to the call published in the international scientific journals Science and Nature and on the HFSP website. The call was also publicized via the web sites or newsletters of relevant scientific societies. A two-step review process was used. Guidelines and application forms for both the letter of intent (the first step) and for full applications (the second step) were provided on the web, and the submission and review of applications were entirely electronic. The deadline for letters of intent was 31 March 2010. Interest in the 2011 cycle was essentially the same as in the 2010 cycle (Fig. 2-1).

Fig. 2-1: Research Grant applications and awards

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The 674 letters of intent received were initially Each full application was evaluated by mail (external) screened on the basis of formal eligibility. This reviewers who submitted a written report and by two included 7 renewal applications from Young members of the Review Committee for Research Investigator teams (a trial initiative authorised by the Grants. Scientific merit, innovation and inter- Board in December 2009). Only a few letters of intent disciplinarity were the most important criteria in the were rejected on the grounds of eligibility. Since 2005, evaluation of the projects. Internationality, and triage has been introduced to reduce the response especially intercontinentality, and the participation time for inappropriate applications; a small scientific of researchers early in their careers also ranked highly, committee including the Chair and Vice-Chair of the not only in the case of Young Investigator but also in Review Committee screened the letters of intent and Program Grant applications. The Young Investigators’ those that did not meet the scientific aims of the applications were reviewed separately in the same Program, 36 applications in all, did not enter the full manner as Program Grants. The Review Committee review process. The Principal Applicant was informed met on 24-26 January 2011 in Strasbourg to discuss as soon as possible so that the team might apply for the 88 full applications and recommended 33 for funding elsewhere. Each remaining letter of intent awards, 11 Young Investigator and 22 Program Grants, was evaluated by two Review Committee members. with a reserve list of 2 Program Grants should funds be The top-scoring projects were examined by a Selection available. The final selection of awards was made by Committee consisting of previous and past members the Council and financial considerations (budgetary of the Review Committees. The Selection Committee restrictions) were taken into account by the Board met from 21 June to 23 June to discuss some 40% of before the recommendations were approved. Both the original submissions (260 new applications and 7 awardees and unsuccessful applicants received Young Investigator renewal applications) and following feedback from the committee in the form of a short these discussions, 91 applicants were invited to submit summary. a full application. None of the Young Investigator renewal applications were considered sufficiently Fig. 2-1 shows the number of applications and awards convincing to justify a full application, but the between award years 2002 and 2011. Between 1990 committee recommended that the initiative should and 2001 there was a single step procedure with an be continued. Teams that were not asked to submit average success rate of c.13%. This was simplified full applications were given brief feedback concerning from 2002 onwards by the introduction of shorter the selection procedure, the evaluation criteria and Letters of Intent where applicants outline their the general classification of their application. collaboration and project. Following an initial review by members of the Grant Review Committee, a Invitations were sent out immediately after the smaller Selection Committee invites full applications Selection Committee meeting. The deadline for the for the more promising proposals. submission of full applications was 14 September 2010. All but three of the invited teams submitted full The numbers of applications and awards using this applications which were reviewed. two step procedure from 2002 onwards are shown in Table 2-1.

Table 2-1: Research Grant applications and awards each year since 2002 (2 step procedure)

Award Letters Full applications Success rate* Total cost in their Awards year of intent invited (%) 1st year (USD million) 2002 548 72 37 51.4 12.35 2003 549 80 31 39.0 10.85 2004 733 67 33 49.2 11.75 2005 719 86 34 39.5 12.75 2006 749 80 32 40.0 11.05 2007 756 80 35 44.3 12.70 2008 774 88 32 36.8 10.65 2009 600 88 35 39.8 12.1 2010 675 84 34 40.5 11.25 2011 674 88 33 37.5 11.40 TOTAL 865**

* based on full applications ** Grand total of awards (1990-2011)

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Fig. 2-2: Countries in which Principal Investigators are working

(a) EU Letter of Intent (c) EU awarded PG: 7 Austria, 3 Belgium, 3 Czech Republic, 4 Denmark, PG: 2 Spain 9 Finland, 5 Greece, 3 Hungary, 9 Ireland, 10 Netherlands, 1 Poland, 2 Portugal, 1 Romania, Others: CDA awardees not in a MSP 26 Spain, 12 Sweden Letter of Intent: 5 Israel (4 PG and 1 YI) and 1 China (YI) YI: 2 Austria, 1 Belgium, 1 Czech Republic, 1 Denmark, Invited: 1 Israel (PG) 1 Finland, 2 Ireland, 6 Netherlands, 4 Spain, Awarded: 1 Israel (PG) 2 Sweden

(b) EU Invited PG: 1 Belgium, 1 Denmark, 1 Netherlands, 2 Portugal, 4 Spain, 1 Sweden YI: 1 Ireland, 1 Netherlands

Table 2-2: Gender distribution in award year 2011

Letter of Intent Invited Program Young Program Young Female No. Scientists 321 76 42 8 % 18.8% 19.7% 18.2% 12.5% Male No. Scientists 1383 310 189 56 % 81.1% 80.3% 81.8% 87.5% TOTAL No. Scientists 1706* 386 231 64

* Program: 2 info refused

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Table 2-3: The distribution of female scientists in awarded applications is the following:

Total Female % Female (2010) Female PI (2010) Program 73 13 17.8 20.0 1 5 Young 32 3 9.4 34.7 0 3 TOTAL 105 16 15.2 23.3 1 8

Fig. 2-3: Countries in which awardees are working

Principal Investigators Co-Investigators EU: 2 Spain. EU: 2 Austria, 1 Belgium, 1 Denmark, 1 Netherlands, Non MSPs: 1 Israel 1 Poland, 1 Spain, 1Sweden Non MSPs: 1 China, 1 Egypt, 3 Israel

(Figs. 2-2, 2-3, Table 2-4) Distribution of awards per country

Fig 2-2 shows the distribution of Principal Investigators for the 2011 awards among various countries and Fig. 2-3 shows the total number of scientists in different countries participating in the international teams. The largest number of applications came from Principal Investigators in the USA and nearly one third of successful applicants (all team members) were working in the USA.

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Table 2-4: Number of applicants and awardees listed by country of institution

Letter of Intent Invited Awarded PG=Program Grants Program Young Total Program Young Total Program Young Total YI=Young Investigators Australia 92 16 108 14 3 17 729* Canada 90 29 119 7 5 12 3 1 4 EU 254(a) 52(a) 306(a) 36(b) 7(b) 43(b) 7(c) 3(c) 10(c) France 100 19 119 13 3 16 3 2 5 Germany 108 32 140 16 7 23 9 3 12 India 17 7 24 1 0 1 0 0 0 Italy 82 16 98 7 7 11 4 0 4 Japan 118 24 142 15 9 24 6 6 12 Korea 12 5 17 1 0 1 0 0 0 New Zealand 18 2 20 4 0 4 1 0 1* Norway 14 3 17 0 0 0 0 0 0 Switzerland 38 13 51 10 3 13 1 3 4 UK 199 34 233 25 5 30 7 2 9 USA 429 104 533 62 15 77 22 7 29 Non MSPs 321 30(a’) 165(a’) 20(b’) 3(b’) 23(b’) 3(c’) 3(c’) 6(c’) TOTAL 1706 386 2092 231 64 295 73 32 105

* 1 awardee moved from New Zealand to Australia during the selection process.

(a) EU Letter of Intent (a’) Non MSPs Letter of Intent PG: 20 Austria, 16 Belgium, 8 Czech Republic, PG: 7 Argentina, 3 Belarus, 6 Brazil, 1 Burkina Faso, 13 Denmark, 1 Estonia, 17 Finland, 7 Greece, 6 Chile, 10 China, 2 Taiwan, 2 Croatia, 2 Cuba, 8 Hungary, 16 Ireland, 1 Lithuania, 42 Netherlands, 1 Egypt, 61 Israel, 1 Kazakhstan, 1 Malaysia, 9 Mexico, 7 Poland, 8 Portugal, 2 Romania, 54 Spain, 1 Peru, 1 Philippines, 5 Russia, 9 Singapore, 2 South 34 Sweden Africa, 1 Turkey, 2 Uruguay, 1 Vietnam, YI: 4 Austria, 5 Belgium, 1 Czech Republic, 3 Denmark, 1 Grenada 2 Finland, 1 Greece, 1 Hungary, 3 Ireland, YI: 1 Brazil, 1 Chile, 6 China, 2 Taiwan, 1 Iceland, 12 Netherlands, 2 Poland, 2 Portugal, 1 Slovakia, 11 Israel, 1 Kenya, 1 Malaysia, 4 Mexico, 1 Serbia, 11 Spain, 4 Sweden 1 Singapore

b) EU Invited PG: 2 Austria, 4 Belgium, 4 Denmark, 1 Finland, 1 Ireland, (b’) Non MSPs Invited 11 Netherlands, 1 Poland, 2 Portugal, 7 Spain, PG: 1 Brazil, 1 Croatia, 1 Egypt, 13 Israel, 2 Mexico, 3 Sweden 2 Singapore YI: 1 Austria, 1 Belgium, 1 Ireland, 2 Netherlands, YI: 1 China, 2 Israel 2 Spain (c’) Non MSPs Awarded (c) EU Awarded PG: 1 Egypt, 2 Israel PG: 1 Austria, 1 Denmark, 1 Netherlands, 1 Poland, YI: 1 China, 2 Israel 2 Spain, 1 Sweden YI: 1 Austria, 1 Belgium, 1 Spain

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2.5

THE 2011 REVIEW COMMITTEE FOR RESEARCH GRANTS

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Italy Lucia BANCI, University of Florence, Sesto Fiorentino

Japan Naoki SUGIMOTO, Konan University, Kobe

Republic of Korea Yunje CHO, Pohang University of Science and Technology, Hyoja Dong

New Zealand John David FRASER, University of Auckland School of Frederick MACKINTOSH, Chair of the Research Grant Review Committee Medicine

Norway Chair Aurora MARTINEZ, University of Bergen Frederick MACKINTOSH, Vrije University, Amsterdam, Netherlands Switzerland Carl PETERSEN, Brain Mind Institute (EPFL), Lausanne Vice-Chair Jyotsna DHAWAN, National Center for Biological United Kingdom Sciences, Bangalore, India Declan BATES, University of Leicester Thomas DUKE, University College London Rose ZAMOYSKA, Research University of Edinburgh

Australia United States of America Robert SAINT, University of Melbourne, Victoria Cheng-Ming CHIANG, UT Southwestern Medical Center, Dallas Canada Mary DICKINSON, Baylor College of Medicine, Paul WISEMAN, McGill University, Montreal Houston Wendy SUZUKI, New York University European Union Elizabeth SZTUL, University of Alabama at Frederick MACKINTOSH, Vrije University, Amsterdam, Birmingham Netherlands Claire WALCZAK, Indiana University, Bloomington Maria SANCHEZ-VIVES, Hospital Clínic of Barcelona, Spain Other Misha TSODYKS, Weizmann Institute of Science, France Rehovot, Israel Cécile SYKES, Institut Curie, Paris Delegate from the Council of Scientists Germany Pascale COSSART, Institut Pasteur, France Michael BRECHT, Humboldt-University, Berlin Jan LOHMANN, University of Heidelberg

India Jyotsna DHAWAN, National Center for Biological Sciences, Bangalore

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Chapter 3

Outreach and Networking

3.1 HFSP Nakasone Award 3.2 Awardees Meeting 3.3 Communications 3.4 Alumni network 3.5 Honours and Prizes

Left to right: Martin REDDINGTON, Rosalyn HUIE (Communications) and Xavier SCHNEIDER (IT manager and webmaster)

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3.1

HFSP NAKASONE

AWARD Michael ELOWITZ, California Institute of Technology, recipient of the HFSP Nakasone Award 2011 for his key studies on noise in gene expression.

The 2011 HFSP Nakasone Award for Michael ELOWITZ honoured by many awards, including the Presidential of the California Institute of Technology Early Career Award for Scientists and Engineers, the most prestigious award given by the U.S. government The idea to establish the prestigious HFSP to early career scientists. Nakasone Award was proposed in July 2009 during the HFSP 20th anniversary celebrations in The letter of nomination clearly outlined the Tokyo in the presence of former Prime Minister importance of Michael Elowitz’s contribution to the frontier of biology: cells must function reliably despite Nakasone. The award honours the vision of inherent stochasticity, or noise, due to the small copy former Prime Minister Nakasone for his efforts number of their components. Prior to Dr. Elowitz’s to launch a program of support for international work, such cellular noise was treated as a mysterious collaboration and to foster early career scientists property, or a nuisance, with no clear way of in a global context. evaluating its extent and functional impact. Dr. Elowitz’s work introduced the conceptual and The HFSP Nakasone Award is designed to honour experimental tools to detect gene expression noise scientists who have undertaken frontier-moving and distinguish it from other sources of variability, to research in biology, encompassing conceptual, quantify its level, and to evaluate its effect on cellular experimental or technological breakthroughs. Both function. Genetic noise is now considered a core senior and junior scientists are eligible and aspect of biology, that functions actively in diverse peer-recognised excellence is the major criterion for cellular functions,including differentiation, regulation, selection. Awardees receive an unrestricted research and . grant of USD 10,000, a medal and a personalised certificate. The award ceremony is held at the annual The impact of this insight is profound. Noise has gone HFSP Awardees Meeting where the awardee delivers from being a curiosity of cellular life to a key process the HFSP Nakasone Lecture. The prize is open to all whose effects must be considered in almost any scientists, not only those who have received funding analysis of biological systems. Thus, stem cell within the HFSP. differentiation and reprogramming are thought to be enabled by stochastic processes, and developmental The 2011 HFSP Nakasone Award was conferred upon cell fates are controlled by noise. It is now even Michael Elowitz of the California Institute of possible to engineer synthetic circuits that exploit or Technology for his pioneering work on the importance reduce noise. Due to the conceptual and technical of noise in gene expression. Michael Elowitz is breakthroughs of Dr. Elowitz, noise is now recognized Professor of Biology, Bioengineering and Applied as an essential and functional ‘text-book’ element that Physics, Bren Scholar and Howard Hughes Medical distinguishes and enables the core cellular behaviours Institute (HHMI) Investigator. His work has been of life.

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discussions, plus the Indian guests. The meeting was generously supported by the Department of Science and Technology and the Department of Biotechnology 3.2 of the Government of India. The meeting was organized by colleagues from the National Centre for Biological Sciences in Bangalore and the Rajiv Ghandi Centre for Biotechnology in Thiruvananthapuram. It featured 28 talks from HFSP awardees. A special ”Spotlight on India” session highlighted the work of current and former HFSP awardees from India. The program also included specialized sessions, so-called “chalkboard sessions”, which enable scientists working in similar fields to get to know each other early in the AWARDEES MEETING meeting. The meeting opened with a ceremony during which the first HFSP Nakasone Award was conferred upon Tenth HFSP Awardees Meeting, Kovalam, Kerala, Karl Deisseroth of Stanford University for his India, 31 October – 3 November 2010 pioneering work on optogenetic methods, which are currently revolutionizing neuroscience research. He The HFSP Awardees Meetings have become an then held the first Nakasone Lecture in which he important event in the HFSP calendar. Their aim demonstrated the many neurobiological themes that is to bring together Grant, Fellowship and Career are being approached using this new set of Development Awardees from all over the world technologies. and from different scientific disciplines to Two special lectures introduced the international present and discuss their work. These HFSP community to issues that are of importance in interactions have become a source of new India. Eminent cardiologist, Prof. M.S. Valiathan talked inspiration for awardees and have led to new about approaches to traditional Ayurveda medicine collaborations. that aim to understand its scientific underpinnings. This was followed by a lecture by Dr. M.K. Bhan from The 10th HFSP Awardees Meeting was held in idyllic the Department of Biotechnology, Government of surroundings in Kerala, in the South of India. All India, on the enormous challenges faced by India in current awardees were invited, as well as the newly developing its scientific capacity and, conversely, on awarded Young Investigator Grant and Career the importance of science in the transformation Development Awardees to encourage these young of India. laboratory leaders to make new contacts in the HFSP community. In addition, 30 young faculty members The meeting was rounded off by a fascinating talk by from Indian institutions were invited to allow them Svante Pääbo from the Max Planck Institute for to gain direct experience of HFSP-funded science and Evolutionary Anthropology in Leipzig, Germany, about to get to know their peers in different countries. his pioneering work on ancient DNA, which led to his publication of the draft genome sequence of The meeting attracted 174 members of the HFSP Neanderthal nuclear DNA in May 2010. community for three full days of talks, posters and

Participants at a chalkboard session

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3.3

COMMUNICATIONS

HFSP’s communication efforts have been discussion forum is available, which allows alumni to intensified over the last year in order to publicise discuss issues of international and frontier science the opportunities provided by the Program and and will be used by the Secretariat to stimulate the exciting results obtained by HFSP awardees. discussion of matters relating to the organization of A key component of our outreach was the awardees and alumni meetings. development of a new HFSP web site, which was launched in February 2011. The redesign places The number of awardees’ articles featured on the web site has increased significantly now that it is possible the science funded by HFSP much more to monitor publication output systematically with a predominantly on the home page. In addition, a weekly alert of new publications entered into the Web clearer distinction is now made between of Science, a leading bibliographic database. HFSP program announcements, awardees’ articles and awardees publish approximately 1000 papers per year other news. citing our support.

A new feature on the site is a section “Frontier News and information about recent awardees’ articles Science”, which features ongoing updates on HFSP continues to be posted on the social networking sites, success stories and other issues relating to Facebook and Twitter. Currently over 500 people follow international, frontier science. Among the articles HFSP on Facebook and approximately 150 on Twitter. posted shortly after the launch of the site are profiles In addition, there is a small but growing HFSP group on of two young postdoctoral fellows who chose the professional networking site LinkedIn for HFSP laboratories in Japan for their HFSP Fellowships and, alumni. conversely, of a young Japanese scientist who “followed his instinct” to go to the best laboratory in An occasional newsletter is sent to approximately the USA to pursue his scientific interests and who 6000 subscribers with announcements of calls for discusses the steps he took to return to Japan. Another applications and news of updates to the web site. The article, by biophysicist James Spudich from Stanford newsletter has been hosted by the University of University, reflects on the impact of a 1993 HFSP- Rennes, France for several years but has now been funded project that stimulated the development of moved to the new HFSP web site. the whole field of single molecule studies. Improvements have also been made in publicizing The web site also features a special section for HFSP the awards made by the Program. Information is sent alumni that allows members of the HFSP community to institutional press contacts to encourage them to to search for collaborators and to make contact with feature HFSP-funded research and to mention HFSP HFSP alumni in their home countries or institutions. support. The mention of HFSP in press releases or More than 500 current and former awardees, members blogs is still modest but was significantly increased of the Board, Council and Review Committees have in 2010 compared to previous years. signed up so far with information on their affiliations, scientific interests and techniques used. In addition, a Outreach to the scientific community has also been

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improved with attendance at international scientific meetings. HFSP was represented with an information booth at the Joint Annual Meeting of the American Society of Plant Biologists and the Canadian Society of Plant Physiologists, Montreal in June 2010 and at the EMBO Meeting, Barcelona in September 2010.

Fourteen HFSP fellows were among the 675 participants of the 60th Nobel Laureate Meeting in Lindau (Germany). Efforts in reaching out to the global network of young scientists will continue with a new Memorandum of Understanding between HFSP and the Council for the Lindau Nobel Laureate Meetings regulating the participation of HFSP fellows until 2013.

HFSP participation in scientific meetings and science policy meetings:

2010 Presentation at the Institute of Molecular Biosciences 24 May, Brisbane, Australia 4 October, Kyoto, Japan Presentation at the Queensland Institute for German-Japanese Science and Innovation Forum, Medical Research 6 October, Tokyo, Japan 25 May, Brisbane, Australia Alexander von Humboldt Foundation, 4th Forum 60th Meeting of Nobel Laureates on the Internationalisation of Sciences and 27 June–2 July, Lindau, Germany Humanities EuroScience Open Forum 10-11 October, Berlin, Germany 2-7 July, Turin, Italy Sino-German Center 10th Anniversary German Research Council, Emmy-Noether-Annual 19 October, Beijing, People’s Republic of China Meeting Presentation at the retreat of Ph. D students of the 16-18 July, Potsdam, Germany Institute of Cancer Research, University of Zurich Plant Biology 2010, Joint Annual Meeting of the 25 October, Interlaken, Switzerland American Society of Plant Biologists & the University of Bonn meeting on ‘Perspektiven und Canadian Society of Plant Physiologists Chancen für Nachwuchswissenschaftlerinnen 31 July–4 August, Montreal, Canada Karrieremöglichkeiten in Deutschland und Europa’ Vallee Foundation Summer Symposium 15 November, Bonn, Germany 2-3 August, Boston, USA European Research Council Workshop ‘Best The EMBO Meeting 2010 Practices in Starting Grants’ Brussels 4-8 September, Barcelona, Spain 18/19 November, Brussels, Belgium Kavli Prize International Science Forum 6 September, Stockholm, Sweden Meeting of the German Association of Naturalists 2011 and Physicians (GDNA) Centenary of Max-Planck Society 17-21 September, Dresden, Germany 11 January, Berlin, Germany 7th Annual meeting of the Science and Technology Indian Young Investigators Meeting in Society Forum 13-17 February, Bhubaneswar, India 3-5 October, Kyoto, Japan Presentation at the University of Pretoria Joint DFG-JST Funding Agency Presidents’ Meeting 31 March, Pretoria, South Africa

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3.4 The year 2010 saw the launch of the HFSP Alumni Network. The alumni initiative satisfies the longstanding wish of HFSP awardees to have a better way to intensify their networking. In the long-term, the initiative may also help in communicating the success of HFSP funded science in the countries that provide financial support for the Program and throughout the scientific communities that take center stage in HFSP HFSP programs. Personal exchanges during the Awardees Meetings and feedback from previous ALUMNI NETWORK HFSPO reviews encouraged the Secretariat to organise two meetings in FY 2010.

The Montreal Botanical Garden provided the delightful setting for the first meeting of HFSP alumni (29 July 2010) that brought together over 30 scientists from Eastern Canada for an entire day with interesting talks and posters. Prof. Anja Geitmann, initiator of this very first HFSP alumni meeting, welcomed the participants. The scientific presentations showed the whole breadth of HFSP science and the alumni used the time to exchange and connect beyond an informal level. The discussions of this very first meeting already proved to be very useful in connecting HFSP scientists in the same region and even across the city with new collaborations emerging. In a general discussion participants discussed the benefits for individual alumni and agreed unanimously that the international scope of the HFSP should be reflected in its alumni network. They suggested that regional meetings in key locations may take turns with meetings connected to large international scientific conferences bringing together HFSP alumni from around the world.

The second meeting of HFSP alumni took place on the Todai-Campus of the University of Tokyo Medical School on 9 October 2010. Amidst the functional research buildings, the Seihoku-Gallery appears as a true marvel of modern Japanese architecture with its cathedral-like Yayoi-Auditorium. Over 60 alumni of the greater Tokyo region listened to research updates by their colleagues and seized the opportunity to learn about ongoing activities during the poster session. The open discussion demonstrated that Japanese scientists are vocal with their points of view when it comes to barriers for international collaborations and researcher mobility. Participants agreed that the HFSP alumni network may help in promoting a greater awareness about opportunities to work abroad among young Japanese researchers. The importance of local or regional meetings was emphasized by one participant who commented that he finally found a collaborator using at a remote end of his own campus.

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3.5

HONOURS AND AWARDS

HFSP GRANTEES AWARDED THE NOBEL PRIZE

Grant awarded Nobel Prize Christiane NÜSSLEIN-VOLHARD 1993 1995 (Physiology or Medicine) Rolf ZINKERNAGEL 1994 1996 (Physiology or Medicine) Stanley PRUSINER 1994 1997 (Physiology or Medicine) John WALKER 1996 1997 (Chemistry) Steven CHU 1993 1997 (Physics) 1994 2001 (Physiology or Medicine) Tim HUNT 1992/1997 2001 (Physiology or Medicine) John SULSTON 1991 2002 (Physiology or Medicine) Peter AGRE 2000 2003 (Chemistry) Linda BUCK 1995 2004 (Physiology or Medicine) Avram HERSHKO 1998 2004 (Chemistry) Roger KORNBERG 1990/1993/1997/2000 2006 (Chemistry) Roger TSIEN 1995 2008 (Chemistry) Jack SZOSTAK 2000 2009 (Physiology or Medicine) Venkatraman RAMAKRISHNAN 2000/2009 2009 (Chemistry) Ada YONATH 2003 2009 (Chemistry)

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The following section lists HFSP awardees who have been honoured with awards and prizes in FY 2010.

Year of HFSP Award 2010 Name Nationality Current affiliation award

AGENCE NATIONALE DE LA RECHERCHE

Programme Retour Aude PANATIER France University of Montreal, Canada LT 2007 Post-doctorants Olivier RIVOIRE France The Rockefeller University, New York, USA CDF 2006

AMERICAN ACADEMY OF ARTS AND SCIENCES MEMBERS Physics David WEITZ Canada/USA , Cambridge, USA PG 2005 Chemistry Martin GRUEBELE USA University of Illinois at Urbana-Champaign, USA PG 2004

Biological David FERSTER USA Northwestern University, Evanston, USA RG 1999 Sciences Michael LEVITT USA Stanford University School of Medicine, Palo Alto, USA PG 2008 Joseph SUDHOF USA Stanford University School of Medicine, Palo Alto, USA RG 1995

FOREIGN HONORARY MEMBER

Evolutionary and Linda PARTRIDGE UK University College London, UK and Max Planck RG 1993 population biology Institute for the Biology of Ageing, Cologne, and ecology Germany

AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE FELLOWS

Biological Joerg BOHLMANN Germany University of British Columbia, Vancouver, Canada YI 2001 Sciences Roger BRENT USA Fred Hutchinson Cancer Research Center, Seattle, USA RG 1990 Donald BRYANT USA Pennsylvania State University, University Park, USA RG 1997 Patrick SCHNABLE USA Iowa State University, Ames, USA RG 1997 Germany/ Max-Planck Institute for Developmental Biology, RG 1997, PG USA Tübingen, Germany 2001, 2007 William WICKNER USA Dartmouth Medical School, Hannover, USA RG 1991, PG 2001 Engineering Richard WILLSON USA University of Houston, USA RG 1993 Neuroscience Edward CALLAWAY USA The Salk Institute for Biological Sciences, La Jolla, USA PG 2009 Roger TRAUB USA IBM T.J. Watson Research Center, Yorktown Heights, USA RG 1990, 1995 Medical Sciences Gideon DREYFUSS USA University of Pennsylvania School of Medicine, Philadelphia, USA RG 1998 Psychology George MANGUN USA University of California, Davis, USA RG 1997

AUSTRIAN ASSOCIATION OF SMALL AND MIDDLE-SIZED ENTERPRISES

Wilhelm Exner Bertil ANDERSSON Sweden Nanyang Technological University, Singapore RG 1996 Medal

BAYER SCIENCE AND EDUCATION FOUNDATION

Early Excellence Oliver DAUMKE Germany Max-Delbrück Centre for Molecular Medicine, Berlin, LT 2005, in Science Award Germany CDA 2009 Hansen Family Stefan HELL Germany Max Planck Institute for Biophysical Chemistry, PG 2010 Award Göttingen, Germany

CNRS Silver Medal Daniel METZGER France Institut de Génétique et de Biologie Moléculaire RG 1999 et Cellulaire, Illkirch-Graffenstaden

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EUROPEAN MOLECULAR BIOLOGY ORGANISATION MEMBERS Anna AKHMANOVA Netherlands Erasmus University Medical Center, Rotterdam, PG 2008 The Netherlands Yves BARRAL France Swiss Federal Institute of Technology (ETH), Zurich, LT 1996 Switzerland Michael BATE UK University of Cambridge, UK RG 1995 Michel BORNENS France Institut Curie, Paris, France RG 1999, PG 2004 Nicholas BROWN USA Gurdon Institute and University of Cambridge, UK PG 2008 Jason CHIN UK MRC Lab. of Molecular Biology, Cambridge, UK YI 2009 Maria Pia COSMA Italy Center for Genomic Regulation, Barcelona, Spain PG 2010 Marie-Anne FELIX France Université Paris Diderot, France LT 1994, PG 2001 Keith GULL UK University of Oxford, UK PG 2004 Canada/Germany University College London, UK LT 1995, RG 2000 Karl-Peter HOPFNER Germany University of Munich, Germany YI 2005 Zachary MAINEN USA Institute Gulbenkian de Ciência, Oeiras, Portugal PG 2010 Erez RAZ Israel Max-Planck-Institute for Biophysical Chemistry, LT 1994 Göttingen, Germany Carol ROBINSON UK Cambridge University, UK PG 2002 Irmgard SINNING Germany University of Heidelberg, Germany RG 2000 Miltos TSIANTIS Greece/UK University of Oxford, UK ST 1999, PG 2010

ASSOCIATE MEMBERS Michael R. GREEN USA University of Massachusetts Medical School, RG 2000 Worcester, USA Thomas JESSELL UK Columbia University College of Physicians & PG 2001 Surgeons, New York, USA Thomas POLLARD USA Yale University, New Haven, USA RG 2000 Clifford TABIN USA Harvard Medical School, Boston, USA RG 1993

GOLD MEDAL Jason W. CHIN UK MRC Laboratory of Molecular Biology, Cambridge, YI 2009 UK

YOUNG INVESTIGATOR Davide CORONA Italy Istituto Telethon Dulbecco, Palermo, Italy LT 2000, CDA 2004 Oliver DAUMKE Germany Max-Delbrück Center for Molecular Medicine, LT 2005, CDA 2009 Berlin, Germany Taija MÄKINEN Finland Cancer Research UK London Research Institute LT 2004 Silvio RIZZOLI Romania European Neuroscience Institute, Göttingen, LT 2005 Germany Kevin VERSTREPEN Belgium Flanders Institute for Biotechnology (VIB), YI 2007 Heverlee, Belgium Daniel WILSON UK Ludwig-Maximilians-University of Munich, Germany YI 2008

EPPENDORF INTERNATIONAL AND SCIENCE

Eppendorf and Christopher GREGG Canada Harvard University, Cambridge, USA LT 2007 Science Prize for Neurobiology

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EUROPEAN RESEARCH COUNCIL

Advanced Grants Finland University of Helsinki, Finland PG 2001 Bruno AMATI Italy/ European Institute of Oncology, Milan, Italy RG 1997 Switzerland Bruno ANTONNY France Institut de Pharmacologie Moléculaire et Cellulaire, RG 1999 CNRS, Valbonne, France Simon BOULTON UK Cancer Research UK London Research Institute, LT 1998 South Mimms, UK Patrik BRUNDIN Sweden Lund University, Sweden PG 2009 Belgium Flanders Institute for Biotechnology (VIB), Ghent, Belgium RG 1995 Antony CARR UK University of Sussex, Brighton, UK RG 2000 Howard CEDAR Israel The Hebrew University Medical School, Jerusalem, Israel RG 1995 Vincent CROQUETTE France Ecole Normale Supérieure, Paris PG 2007 Mario DE BONO Malta MRC Lab. of Molecular Biology, Cambridge, UK PG 2005 Bart DE STROOPER Belgium Flanders Institute for Biotechnology (VIB), Ghent, Belgium ST 1994, RG 1996 Elisabetta DEJANA Italy Foundation IFOM (Firc Institute for Molecular Oncology, RG 1997 Milan, Italy) Manel ESTELLER Spain Bellvitge Institute for Biomedical Research (IDIBE), PG 2007 L’Hospitalet de Llobregat, Spain Jonas FRISEN Sweden Karolinska Institute, Huddinge, Sweden PG 2004 Wulfram GERSTNER Germany EPFL, Lausanne, Switzerland ST 1995 Rainer GOEBEL Germany University of Maastricht, The Netherlands YI 2001 Peter JONAS Germany Institute of Science and Technology, Austria RG 1998 Ole KIEHN Denmark Karolinska Institute, Huddinge, Sweden RG 1995, PG 2002 Tony KOUZARIDES UK University of Cambridge, UK RG 1998 Nils-Goeran LARSSON Sweden Karolinska Institute, Huddinge, Sweden RG 1999 Vivek MALHOTRA USA Centre for Genomic Regulation (CRG), Barcelona, Spain PG 2001 France International School for Advanced Studies, Trieste, RG 1990, 1995, Italy PG 2002 Richard MORRIS UK University of Edinburgh, UK RG 1990, 1994, PG 2001, 2006 Gioacchino NATOLI Italy European Institute of Oncology, Milan, Italy YI 2005 Bradley NELSON USA Swiss Federal Institute of Technology (ETH), Zurich, PG 2006 Switzerland Linda PARTRIDGE UK University College London, UK and Max Planck Institute RG 1993 for the Biology of Ageing, Cologne, Germany Matthias PETER Switzerland Swiss Federal Institute of Technology (ETH), Zurich, RG 2000 Switzerland Andreas PLUECKTHUN Germany/ University of Zurich, Switzerland RG 1993, PG 2001 Switzerland Benjamin PODBILEWICZ Mexico Technion- Israel Institute of Technology, Haifa, Israel LT 1992, PG 2001 Erez RAZ Israel Max-Planck-Institute for Biophysical Chemistry, LT 1994 Göttingen, Germany Carol V. ROBINSON UK University of Cambridge, UK PG 2002 Giorgio SCITA Italy Foundation IFOM (Firc Institute for Molecular Oncology, PG 2003 Milan, Italy) Jesper SVEJSTRUP Denmark Cancer Research UK London Research Institute, RG 1997 South Mimms, UK Dirk TRAUNER Austria Ludwig-Maximilians-University Munich, Germany PG 2005, 2009 Rienk VAN GRONDELLE Netherlands Vrije Universiteit, Amsterdam, The Netherlands RG 1995, PG 2006 Alfred WITTINGHOFER Germany Max-Plank Institute for Molecular Physiology, RG 1995, 2000 Dortmund, Germany

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EUROPEAN RESEARCH COUNCIL

Starting Grants Gonen ASHKENASY Israel Ben Gurion University of the Negev, Beer Sheva, Israel LT 2002, CDA 2006 Jost ENNINGA Germany Institut Pasteur, Paris, France LT 2005 Nathalie BALABAN Israel/France Hebrew University, Jerusalem, Israel YI 2005 Jérôme BOISBOUVIER France CNRS, Grenoble, France LT 2001, CDA 2004, YI 2006 Jonathan COLEMAN Ireland Trinity College, Dublin, Ireland YI 2005 Frederic GEISSMANN France Hopital Necker, Paris, France LT 2000 Joost GRIBNAU Netherlands Erasmus University Medical Center, Rotterdam, LT 2001, CDA 2004 The Netherlands Stephan GRUBER Austria Max Planck Institute of , Martinsried, LT 2007 Germany Uri HASSON Israel Universita degli Studi di Trento, Italy LT 2004 Peter JANSSEN Belgium Catholic University of Louvain, Belgium LT 2001, CDA 2005 Luca JOVINE Italy Karolinska Institute, Huddinge, Sweden LT 2001 Sebastien KADENER Argentina/ The Hebrew University, Jerusalem, Israel LT 2003, CDA 2009 Israel Helder MAIATO Portugal University of Porto, Portugal YI 2010 Sophie MARTIN Switzerland University of Lausanne, Switzerland LT 2003, CDA 2008 Tam MIGNOT France CNRS, Marseille, France YI 2008 Marcelo NOLLMANN Argentina/ INSERM, Montpellier, France LT 2006, CDA 2009 Spain Vikram PANSE India Swiss Federal Institute of Technology (ETH), Zurich, LT 2000 Switzerland Suman PEEL India University of Bristol, UK LT 2007 James POULET UK Max Delbrück Centre for Molecular Medicine, LT 2005 Berlin, Germany Botond ROSKA Hungary Friedrich Miescher Institute, Basel, Switzerland ST 2000, YI 2003 Gerhard SCHRATT Germany University of Heidelberg, Germany LT 2002, CDA 2006 Maya SCHULDINER Israel Weizmann Institute of Science, Rehovot, Israel LT 2002, CDA 2008 Maria Teresa TEIXEIRA Portugal École Normale Supérieure, Lyon, France LT 2000 Nicolas THOMA Germany Friedrich Miescher Institute, Basel, Switzerland LT 2002 Pavel TOMANCAK Czech Max Planck Institute of Molecular Cell Biology and YI 2008 Republic Genetics, Dresden, Germany Rein ULIJN Netherlands University of Strathclyde, Glasgow, UK PG 2008 Gijs JL WUITE Netherlands University of Cambridge, UK PG 2010 Roie YERUSHALMI Israel Hebrew University, Jerusalem, Israel LT 2005, CDA 2008 Helder MAIATO Portugal University of Porto, Portugal YI 2010 Tam MIGNOT France CNRS, Marseille, France YI 2008

FEDERATION OF EUROPEAN NEUROSCIENCE SOCIETIES

Boehringer-Ingelheim Fekrije SELIMI France Université Pierre et Marie Curie, Paris, France LT 2001 FENS Research Award 2010

GAIRDNER FOUNDATION

Canada Gairdner Pierre CHAMBON France Institut de Génétique et de Biologie Moléculaire et RG 1991, 1999 International Cellulaire, Illkirch-Graffenstaden, France Award

GERMAN RESEARCH COUNCIL

Leibniz Prize Petra SCHWILLE Germany Dresden University of Technology, Germany PG 2002, 2005

YAD HANADIV FOUNDATION

Michael Bruno Nir FRIEDMAN Israel Hebrew University, Jerusalem, Israel PG 2005 Memorial Award

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INSTITUTE OF MEDICINE

Member Netherlands The Rockefeller University, New York, USA RG 1997

JAPAN ACADEMY

Japan Academy Keiji TANAKA Japan The Tokyo Metropolitan Institute of Medical Science, RG 1995 Prize Japan

LOUIS JEANTET FOUNDATION

Louis Jeantet Austin SMITH UK Wellcome Trust Centre for Stem Cell Research, RG 1996, 2000 Prize for Medicine University of Cambridge, UK

NATIONAL ACADEMY OF SCIENCES

Award in Chemical Stephen BENKOVIC USA Pennsylvania State University, University Park, USA PG 2007 Sciences Members Philip BENFEY USA Duke University, Durham, USA RG 1995 Susan GOLDEN USA University of California, San Diego, USA RG 1996 James HABER USA Brandeis University, Waltham, USA RG 2000 Barbara IMPERIALI USA Massachusetts Institute of Technology, Cambridge, PG 2006 USA Patricia KUHL USA University of Washington, Seattle, USA RG 1999 Terrence SEJNOWSKI USA Salk Institute for Biological Studies, La Jolla, USA RG 1996, 2000 David WEITZ Canada Harvard University, Cambridge, USA PG 2005 Zena WERB Canada/USA University of California, San Francisco, USA RG 1999 King-Wai YAU USA Johns Hopkins University School of Medicine, RG 2000 Baltimore, USA Foreign Wolfgang BAUMEISTER Germany Max-Planck Institute for Biochemistry, RG 1995, PG 2003 Associates Martinsried, Germany France Institut National de la Santé et de la Recherche PG 2007 Médicale (INSERM), Paris , France

NATIONAL INSTITUTES FOR HEALTH

Pioneer Award Pamela BJORKMAN USA Howard Hughes Medical Institute, Pasadena, USA RG 1993 David KLEINFELD USA University of California, San Diego, USA PG 2004 Andres MARICQ USA University of Utah, Salt Lake City, USA PG 2006 Miguel NICOLELIS Brazil Duke University, Durham, USA RG 1999

NATIONAL SCIENCE FOUNDATION

National Medal Stephen BENKOVIC USA Pennsylvania State University, University Park, USA PG 2007 of Science USA Massachusetts Institute of Technology, Cambridge, USA RG 1992 Stanley PRUSINER USA University of California, San Francisco, USA RG 1994

NORWEGIAN ACADEMY OF SCIENCE AND LETTERS

Kavli Prize in USA Yale University, New Haven, USA RG 1990, 1994, Neuroscience PG 2005 Joseph SUDHOF USA Stanford University School of Medicine, Palo Alto, RG 1995 USA

OFFICE OF SCIENCE AND TECHNOLOGY OF THE PRESIDENT (OSTP)

Presidential Early Joshua SHAEVITZ USA , USA YI 2008 Career Award for Scientists and Engineers

PEW CHARITABLE TRUST

Pew Scholar in the Susan SCHWAB USA Skirball Institute of Biomolecular Medicine, LT 2009 Biomedical New York University, USA Sciences

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ROSENSTIEL BASIC MEDICAL SCIENCES RESEARCH CENTER

Lewis Rosenstiel Jules HOFFMANN France Université de Strasbourg, France RG 1995 Award for Distinguished work in Basic Medical Science

ROYAL SOCIETY

Fellow Paul BRAKEFIELD UK Institute of Biology, Leiden University, RG 1998 The Netherlands Andrea Hilary BRAND UK/USA Wellcome Trust/Cancer Research UK Gurdon Institute, RG 1997 University of Cambridge, UK Raymond DOLAN Ireland University College London, UK PG 2004 Angus LAMOND UK University of Dundee, UK PG 2001 Germany University of Cambridge, UK RG 1999 Foreign Member Edmond FISCHER USA University of Seattle, Washington, USA RG 1994 Detlef WEIGEL Germany/ Max-Planck Institute for Developmental Biology, RG 1997, PG 2001, USA Tübingen, Germany 2007

CHICA UND HEINZ SCHALLER FOUNDATION

Chica und Heinz Gerhard SCHRATT Germany University of Heidelberg, Germany LT 2002, CDA 2006 Schaller Preis

SCIENCE MAGAZINE

Essays on Science Christopher GREGG Canada Harvard University, Cambridge, USA LT 2007 and Society Grand Prize Winner 2010

THIRD WORLD ACADEMY OF SCIENCES

TWAS Prize Satyajit MAYOR India National Centre for Biological Sciences, Bangalore, RG 1996, PG 2005 India

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Chapter 4

Budget and Finance

4.1 Guidelines for HFSPO funding 4.2 Key financial figures for FY 2010 4.3 FY 2010 Financial Summary 4.4 Budget for program activities FY 2011

Left to right: Jennifer SAYOL, Isabelle HEIDT-COQUARD, Sarah NAETT-CAZAU and Akihiko TANAKA

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4.1 4.2

GUIDELINES FOR KEY FINANCIAL HFSPO FUNDING FIGURES FOR FY 2010

HFSP is supported by voluntary contributions At HFSPO, the fiscal year (FY) extends from 1 April to from its MSPs: Australia, Canada, France, 31 March of the following year. Germany, India, Italy, Japan, Republic of Korea, New Zealand, Norway, Switzerland, the United Figures are reported in million USD unless stated otherwise. Different exchange rates are used in this Kingdom, the United States of America and the report for different purposes: European Union. ● IGC Canberra reference rates: these are used to MSPs hold regular IGCs at which the intended monitor the implementation of the IGC budgetary level of contribution for the next budgetary guideline in USD over extended periods and avoid period is established as a guideline for the Board. the risk of any distortion arising from variations The last IGC in Canberra in May 2010 established in the exchange rate. Reference rates may differ a three-year indicative budgetary guideline for from actual rates. the period FY 2011 to FY 2013. ● FY 2010 budget rate: the exchange rate used for the budget. In principle, the Canberra guideline is based on a 4% annual increase of MSPs’ contributions. The ● FY 2010 daily accounting rates: these are used for Canberra IGC guideline was established in local HFSPO’s legal accounts and their consolidation in currency (LC). USD reference rates were set for EUR or in USD. They are updated daily on the basis the next three years (Table 4-1). of data published by the European Central Bank.

The average actual exchange rates governing transactions between the USD and the main currencies used by HFSPO in FY 2010 were close to those used in the budget.

Table 4-1: Exchange rates used in FY 2010 report

Exchange rates 1 USD = CAD CHF EUR GBP Ottawa IGC for 2008-2010 1.3 1.24 0.8 0.55 Budget FY 2010 1.00 1.14 0.75 0.65 Actual FY 2010 (average) 1.01 1.01 0.75 0.64 Canberra IGC for 2011 to 2013 1.00 1.14 0.75 0.65

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4.2.1

CONTRIBUTIONS

Some contributions received in FY 2010, the last year of the Ottawa three-year budgetary guideline, are significantly different from the 2010 goal signed in Ottawa in 2007. Japan and France have considerably reduced their contributions. Contributions received from MSPs during FY 2010 are shown in the agreed currencies in Table 4-2.

Table 4-2: Contributions received in FY 2010 in currencies (1 April 2010 to 31 March 2011) Payments Comparison with Ottawa Goal Ottawa Plan B Joint Comparison with Actual payment Actual payment Communiqué Ottawa goal LC in USD (at for 2010 (Local Currency) accounting rate) USD USD Australia 598 000 USD $ 598 000 $ 598 000 0 Canada 1 465 480 CAD $ 1 440 869 $ 1 190 000 250 869 EU 4 153 000 EUR $ 5 334 334 $ 5 191 000 143 334 France 1 504 600 EUR $ 1 999 928 $ 2 966 000 -966 072 Germany 3 649 000 EUR $ 5 036 716 $ 4 561 000 475 716 India 879 000 EUR $ 879 000 $ 879 000 0 Italy 799 313 EUR $ 1 092 495 $ 981 000 111 495 Japan 29 522 758 USD $ 29 522 758 $ 31 248 000 -1 725 242 Korea 694 000 USD $ 694 000 $ 694 000 0 New-Zealand 113 000 USD $ 113 000 $ 113 000 0 Norway 541 000 USD $ 541 000 $ 541 000 0 Switzerland 850 000 CHF $ 818 436 $ 638 000 180 436 UK 1 210 000 GBP $ 1 815 784 $ 2 263 000 -447 216 USA 9 930 320 USD $ 9 930 320 $ 10 137 000 -206 680

$ 59 816 640 $ 62 000 000 -2 183 360 96.5% Goal compared to real payment The total level of contributions paid for FY2010, corresponded to 96.5 % of Ottawa plan B goal. ● For FY 2010, Japan decreased its contribution by 5.5%, paying 1.725 million USD less than the Ottawa goal. ● France has settled 67 % of the Ottawa financial guideline1, contributing 0.966 million USD less than the Ottawa goal. ● The contribution from the UK was also below the guideline, due to exchange rate fluctuations. ● The US has paid 9.930 million USD, 0.207 million USD less than the Ottawa goal. ● As of 31 March 2010, the Indian contribution remained unpaid, but the contribution was officially confirmed and thus can be reported in accordance with HFSPO’s financial guidelines. All other MSPs matched or increased their FY 2010 contribution, providing a total of 59.817 million USD.

Table 4-2 indicates a 2.183 million USD shortfall in payments with respect to the Ottawa goal. However, since the budgeted contribution was 60.140 million USD, as shown in Table 4-5, the budgetary goal was almost attained.

1 In FY 2009, France contributed 74% of the Ottawa goal.

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Since the beginning of the Program and at end of FY 2011, 1.093 billion USD has been received from the joint contributions of all MSPs (Table 4-3). Japan is an exceptionally generous contributor, providing 66.1 % of the total (722.4 million USD paid since 1989). The next most significant contributors are the USA (12.4 %), the European Union (5.3 %) and Germany (5.1 %).

Table 4-3: Actual contributions from MSPs per fiscal year at budget exchange rate (million USD)

European New Switzer- Annual Australia Canada France Germany India Italy Japan Korea Norway UK USA TOTAL Union Zealand land increase FY 1989 - - - 0.460 - - 0.020 9.940 ------10.420 FY 1990 - 0.200 - 1.650 0.290 - 0.330 28.950 ------31.420 201.5% FY 1991 - 0.000 0.150 1.620 0.910 - 0.440 28.440 - - - 0.400 - 0.040 32.000 1.8% FY 1992 - 0.400 0.180 1.320 0.770 - 0.190 29.570 - - - 0.400 0.510 0.040 33.380 4.3% FY 1993 - 0.330 0.910 1.250 0.810 - 0.180 31.300 - - - 0.400 0.540 3.500 39.220 17.5% FY 1994 - 0.540 1.110 1.560 0.990 - 0.180 34.010 - - - 0.400 0.590 3.500 42.880 9.3% FY 1995 - 0.530 1.000 1.740 1.220 - 0.190 35.650 - - - 0.590 0.580 3.500 45.000 4.9% FY 1996 - 0.260 0.920 1.370 1.170 - 0.180 36.730 - - - 0.510 0.630 4.000 45.770 1.7% FY 1997 - 0.250 0.870 1.470 1.020 - 0.170 37.380 - - - 0.530 0.760 4.000 46.450 1.5% FY 1998 - 0.450 1.110 1.700 1.250 - 0.290 35.840 - - - 0.580 0.760 4.500 46.480 0.1% FY 1999 - 0.440 1.680 1.750 1.600 - 0.290 35.770 - - - 0.610 0.750 5.000 47.890 3.0% FY 2000 - 0.450 1.520 1.580 2.100 - 0.260 37.380 - - - 0.550 0.750 5.500 50.090 4.6% FY 2001 - 0.510 0.870 1.160 2.840 - 0.680 37.050 - - - 0.520 0.800 7.390 51.820 3.5% FY 2002 - 0.830 2.380 1.400 1.530 - - 31.250 - - - 0.530 1.550 8.600 48.070 -7.2% FY 2003 - 0.810 4.720 1.910 3.940 - - 31.250 - - - 0.630 1.470 10.400 55.130 14.7% FY 2004 - 0.850 4.080 2.070 3.430 - 2.120 31.250 - - - 0.690 1.630 9.500 55.620 0.9% FY 2005 0.470 0.870 4.510 2.170 3.500 - 0.840 31.250 0.550 - - 0.690 1.720 9.000 55.570 -0.1% FY 2006 0.485 0.960 4.690 2.350 3.820 - 0.880 31.250 0.570 0.095 - 0.690 1.790 9.000 56.580 1.8% FY 2007 0.504 1.200 5.500 2.800 4.700 0.780 1.400 31.250 0.600 0.099 - 0.800 2.200 9.000 60.833 7.5% FY 2008 0.534 1.313 5.573 3.034 4.913 0.812 0.909 31.300 0.624 0.103 0.500 0.784 2.238 9.364 62.000 1.9% FY 2009 0.566 1.238 5.454 2.318 4.853 0.844 1.034 31.248 0.658 0.108 0.520 0.770 1.877 9.832 61.320 -1.1% FY 2010 0.598 1.465 5.537 2.006 4.865 0.879 1.066 29.523 0.694 0.113 0.541 0.746 1.862 9.930 59.825 -2.4% FY 2011 Budget 0.622 1.611 5.739 2.071 5.060 0.914 1.088 24.773 0.722 0.118 0.563 0.664 1.935 9.930 55.810 -6.7%

TOTAL 3.8 15.5 58.5 40.8 55.6 4.2 12.7 722.4 4.4 0.6 2.1 12.5 24.9 135.5 1 093.6 0.3% 1.4% 5.3% 3.7% 5.1% 0.4% 1.2% 66.1% 0.4% 0.1% 0.2% 1.1% 2.3% 12.4% 100%

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4.2.2

PAYMENT OF AWARDS

HFSPO paid 59.026 million USD to its awardees during FY 2010, as shown in Table 4-4.

● Research Grant payments amounted to 34 million ● Payments to CDA holders amounted to 6.8 million USD, as shown in Table 4-4. This constitutes around USD and constitute 12% of payments in FY 2010. 57% of payments made in FY 2010. ● Funds paid to the last Short-Term Fellows amounted ● Payments to Long-Term and Cross-Disciplinary to less than 100 000 USD. This program was fellows correspond to 30% of payments in FY 2010. terminated in FY 2010. Actual payments were slightly below budget for two reasons observed each year: ● Resources allocated to the 10th HFSP Awardees - Some payments planned for FY 2010 were Meeting in Kerala, India, and other outreach postponed for reasons such as parental leave or activities, amounted to approximately 400 000 USD. deferral of the third year in the event of repatriation. These payments were transferred to the following fiscal years. - Some fellows terminated earlier than scheduled eg. to take up a permanent position. The annual attrition rate is close to 5% and is taken into account when calculating the number of fellowships fundable each year.

Fig. 4-1: Payments made in FY 2010 by type of award/activity

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4.2.3 With regard to contributions, the Asia Pacific region, including the Japanese contribution, remains the main source of funding, contributing 53.1 % of the total in GEOGRAPHICAL DISTRIBUTION 2010, as compared with 53.5 % in FY 2009. Next year with the continuing decrease, this will fall to 48.7 %. The Asia-Pacific region is followed by Europe, which contributed 27.8 % as compared with 28.6 % in FY 2009 and North America, which contributed 19 % as compared with 17.8 % in FY 2009.

Fig. 4-2: Geographical distribution between 2009 and 2011

Fig. 4-3: Geographical distribution of contribution by country in FY 2010

50 45 40 35 30 25 20 15 10 5 0

Australia Canada E.U. France Germany India Italy Japan Korea New Zealand Norway Switzerland UK USA FY 2010 1.0% 2.4% 9.3% 3.4% 8.1% 1.5% 1.8% 49.3% 1.2% 0.2% 0.9% 1.2% 3.1% 16.6%

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Table 4-4 and Fig. 4-4 show the geographical distribution of award payments.

45.7% of the total amount of awards paid in FY 2010 region, of which 5.88% in Japan (cf. 10.7% for the Asia went to awardees in Europe (cf. 46% in FY 2009). 41.1% Pacific in FY 2009). 4% of awards were paid to awardees was allocated to awardees in North America (cf. 38.5% in non MSPs (cf. 4.8% in FY 2009). in FY 2009). 9.2% went to awardees in the Asia-Pacific

Table 4-4: Geographical distribution of award payments per MSP for the major programs in FY 2010 (million USD)

Long-Term+ Career Research Short-Term MSP % Cross-Disciplinary % Development % Total % Total Grants Fellowships Fellowships Awards Australia 0.771 2.27% 0.283 1.56% 0.200 2.95% 0.008 1.262 2.14% Canada 1.659 4.88% 0.345 1.90% 0.700 10.34% 0.009 2.713 4.60% EU 4.569 13.45% 0.942 5.18% 0.700 10.34% 0.039 6.250 10.59% France 2.145 6.31% 0.660 3.63% 1.072 15.83% - 3.877 6.57% Germany 3.190 9.39% 1.557 8.56% 1.100 16.24% - 5.847 9.91% India 0.100 0.29% - 0.00% 0.100 1.48% - 0.200 0.34% Italy 0.728 2.14% 0.036 0.20% 0.100 1.48% - 0.864 1.46% Japan 2.503 7.37% 0.168 0.92% 0.800 11.81% - 3.471 5.88% Korea 0.116 0.34% - 0.00% - 0.00% - 0.116 0.20% New Zealand 0.382 1.12% - 0.00% - 0.00% - 0.382 0.65% Norway - 0.00% 0.076 0.42% - 0.00% - 0.076 0.13% Switzerland 1.257 3.70% 1.724 9.48% 0.200 2.95% - 3.180 5.39% UK 4.860 14.31% 1.738 9.55% 0.300 4.43% - 6.898 11.69% USA 10.880 32.03% 10.440 57.39% 0.200 2.95% 0.032 21.552 36.51% Non MSPs 0.807 2.38% 0.222 1.22% 1.300 19.20% 0.007 2.337 3.96% Grand Total 33.967 100.0% 18.193 100.0% 6.772 100.0% 0.095 59.026 100.0%

Fig. 4-4: Geographical distribution of total awards over all programs paid by HFSP in FY 2010

New Non Australia Canada EU France Germany India Italy Japan Korea Norway Switzerland UK USA Zealand MSPs % total 2.14% 4.60% 10.59% 6.57% 9.91% 0.34% 1.46% 5.88% 0.20% 0.65% 0.13% 5.39% 11.69% 36.51% 3.96%

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Fig. 4-5: Fig. 4-6: Overview of payments to grant team members Award payments to HFSP fellows in FY 2010 according to country according to host country

Australia 2% Canada 2%

Non MSPs 1% E.U. 5% USA 57% France 4%

Germany 9%

India 0% Italy 0% Japan 1% Korea 0% Norway 0% New Zealand 0%

UK 10% Switzerland 9%

Fig. 4-7: Award payments to CDA holders according to host country

UK 4% USA 3% Switzerland 3% Non MSPs 19% Korea 0% Norway 0% New Zealand 0% Japan 1%

Italy 2% Australia 3%

India 2%2%India

Germany 16% Canada 10% France 16% E.U. 10%10%E.U.

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4.3

FY 2010 FINANCIAL SUMMARY

The accounting summary (Table 4-5) provides an overview of income and expenditures. Together, these result in the net financial position.

Contributions paid in currencies other than the USD are consolidated at the exchange rate of the date of payment.

Table 4-5: HFSPO accounting summary FY 2010 (budget and actual rates)

Income/ current Budget 2010 Report FY 2010 Budget 2010 Report FY 2010 commitments in m LC in m LC in m USD in m USD

1. Contributions 60.140 59.816 Australia USD 0.598 0.598 0.598 0.598 Canada CAD 1.549 1.465 1.549 1.441 European Union EUR 4.153 4.153 5.537 5.334 France EUR 1.692 1.505 2.256 2.000 Germany EUR 3.649 3.649 4.865 5.037 India* USD 0.879 0.879 0.879 0.879 Italy EUR 0.785 0.799 1.047 1.092 Japan USD 29.523 29.523 29.523 29.523 Korea USD 0.694 0.694 0.694 0.694 New Zealand USD 0.113 0.113 0.113 0.113 Norway USD 0.541 0.541 0.541 0.541 Switzerland CHF 0.850 0.850 0.746 0.818 UK GBP 1.210 1.210 1.862 1.816 USA USD 9.930 9.930 9.930 9.930

2.Interest and capital gain (estimate) 1.000 0.490

3. Miscellaneous reimbursements 0.000 0.317 4. Committed funds from previous fiscal year 63.396 64.296 Program Grants 24.350 24.350 Young Investigators 10.600 10.600 Fellowships 21.346 21.346 Career Development Awards 7.100 8.000

Total income 124.536 124.919 Balance (negative) GRAND TOTAL 124.536 124.919 * not yet received

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Table 4-5: HFSPO accounting summary FY 2010 (budget and actual rates) continued

Budget 2010 Report FY 2010 Expenditures/ new commitments in m USD in m USD

1. Administrative expenses 4.739 4.840

2. Program activities 58.948 59.426 Program Grants 23.750 23.716 Young Investigators 10.250 10.250 Fellowships 18.498 18.193 Career Development Awards 6.100 6.772 Short-Term Fellowships 0.000 0.095 Awardees meetings and outreach activities 0.350 0.400

3. Committed funds beyond fiscal year 60.591 58.363

Program Grants 26.000 26.000 Young Investigators 8.600 8.600 Fellowships 20.191 18.163 Career Development Awards 5.800 5.600

Total Expenses 124.278 122.629

Annual balance 0.258 2.290

GRAND TOTAL 124.536 124.919

Financial income Running costs of the HFSP (administrative expenses) and Program activities Income from financial operations amounted to 0.49 million USD, compared to 2.68 million USD last The Organization and its 16 staff members are year. Investments are made in short and medium responsible for the management and implementation term structured products2 and tailored to the of the Program and the fulfilment of its mission. Since payment schedule of awards. All investments comply HFSPO is located in France, its running costs occur with HFSPO’s prudential rules. In FY 2010, three long mostly in EUR. Due to the high impact of the investments initiated in 2007 did not produce a return EUR/USD exchange rate, expenses for FY 2010 on investment. Only the invested capital was amounted to 4.84 million USD, slightly in excess of reimbursed. the 4.74 million USD budgeted. Program expenses reached 59.426 million USD. Research Grant payments are almost on budget, Fellowships are slightly under 2. Monetary mutual funds (SICAV or Société d’Investissement à Capital budget, as several fellows finished their award earlier Variable) and EMTN (Euro Medium Term Notes) with capital guaranty at maturity. than expected and payments to CDA holders are over budget because some payments in FY 2009 were postponed to FY 2010.

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4.4 4.4.1 BUDGET FOR PROGRAM ACTIVITIES CONTRIBUTIONS

FY 2011 The budgetary guideline adopted at the HFSP IGC in Canberra in May 2010 for the period FY 2011-2013, in the currencies of contribution and converted into USD, served as the basis for budgetary planning for FY 2011, as shown in Table 4-6.

Table 4-6: The budgetary guideline from the Canberra Joint Communique (2011-2013) in USD and currency of contribution

BUDGET BUDGET BUDGET MSP rates FY 2011 (+ 4%) USD FY 2012 ( + 4%) USD FY 2013 ( + 4%) USD Exchange in k LC in k LC in k LC AUSTRALIA 622 647 673 USD 622 647 673 CANADA 1 1 611 1 675 1 742 CAD 1 611 1 675 1 742 EU 0.75 5 759 5 989 6 229 € 4 319 4 492 4 672 FRANCE* 0.75 2 071 2 153 2 239 € 1 553 1 615 1 679 GERMANY 0.75 5 060 5 262 5 473 € 3 795 3 947 4 105 INDIA 914 951 989 USD 914 951 989 ITALY 0.75 1 089 1 132 1 177 € 816 849 883 JAPAN 29 523 29 523 29 523 USD 29 523 29 523 29 523 NEW ZEALAND 118 123 128 USD 118 123 128 NORWAY 563 585 608 USD 563 585 608 REPUBLIC OF KOREA 722 751 781 USD 722 751 781 SWITZERLAND 1.14 664 690 718 CHF 757 787 818 UK 0.65 1 936 2 013 2 094 GBP 1 258 1 309 1 361 USA 10 327 10 740 11 170 USD 10 327 10 740 11 170 ALL MSP Actual 60 977 62 236 63 543

JAPAN 48.4% 47.4% 46.5%

* France: indicative figures

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As stated in the Canberra Communiqué (Appendix 2), representatives agreed to continue to support and ensure the future success of the Program. To this end, MSPs other than Japan agreed to increase their contributions by 4% annually, as shown in Table 4-6.

Most MSPs confirmed their contribution for FY 2011 at the Board meeting in March 2011.

Table 4-7: MSPs’ contributions budgeted for FY 2011 in the currency of contribution and USD at budget rate

2011 IGC Budget confirmed by MSPs' Comparison BUDGET INCOME Canberra reference for FY 2011 with FY 2010 2011 in k LC in k LC in k LC in k USD Australia USD 622 622 0 622 Canada CAD 1 611 1 611 0 1 611 EU EUR 4 319 4 319 0 5 759 France (1) EUR 1 553 1 553 0 2 071 Germany EUR 3 795 3 795 0 5 060 India USD 914 914 0 914 Italy EUR 816 816 0 1 089 Japan USD 29 523 24 773 -4 750 24 773 Korea USD 722 722 0 722 New Zealand USD 118 118 0 118 Norway USD 563 563 0 563 Switzerland CHF 757 757 0 664 UK GBP 1 258 1 258 0 1 936 USA USD 10 327 9 930 -397 9 930 TOTAL CONTRIBUTIONS 55 832 Exchange rate : 1 USD = 1 CAD = 1,14 CHF = 0,75 EUR = 0,65 GBP. (1) Indicative figure for France, to be confirmed

The FY 2011 budget will not attain the Canberra goal (60.977 million USD) by 5.155 million USD, mainly due to shortfalls in the Japanese and US contributions and some uncertainty as regards the French contribution, as shown in Table 4-6 and Table 4-7.

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4.4.2

PROGRAM ACTIVITIES

● The Program activity plan, adopted by the Board Table 4-8: on 28 March 2011, followed the recommendation of Funding of Program activities for FY 2011 in the Council. Within the limits of projected budget, number of awards and value the funding capacity for 2011 is as follow: FY 2011 PROGRAM ACTIVITIES Number • 22 Program Grants USD • 11 Young Investigators Program Grants 43.5% 25 200 • 85 Long-Term and Cross-Disciplinary Fellowships, PG 2009/3 26 9 000 • 8 Career Development Awards PG 2010/2 25 8 450 PG 2011/1 22 7 750 ● Program activities in FY 2011 will cost 57.888 Young Investigators 16.5% 9 550 million USD, as shown in Table 4-8. The table also YI 2009/3 9 3 100 shows the nature of these activities. YI 2010/2 9 2 750 YI 2011/1 11 3 700 ● Program activities for FY 2011 also include the 11th Long-Term Fellowships 30.2% 17 506 HFSP Awardees meeting in Montreal, Canada, the LT 2006-7/3 4 204 Nakasone Award 2011, two Alumni network LT 2008/3 34 1 333 meetings, a Career Day in Japan3, attendance at scientific meetings and travel for Council and LT 2009/3 (115) 110 6 306 Review Committee members. Expenses for these LT 2010/2 (86) 85 4 778 will amount to 832 kUSD. LT 2011/1 (85) 85 4 885 Career Development Awards 8.3% 4 800 3. The Career Day is intended to promote mobility among young postdoctoral CDA 2009/3 24 2 400 researchers. CDA 20010/2 16 1 600 CDA 2011/1 8 800 Other activities 1.4% 832 Awardees meetings 250 Program meetings (Review cycle) 400 Outreach activities - Alumni network 142 Nakasone Award 40 TOTAL PROGRAM ACTIVITIES 100% 57 888

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4.4.3

INCOME AND BUDGETED EXPENDITURE FOR FISCAL YEAR 2011

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Table 4-9 presents a prospective financial summary income from investments, the total amount available for FY 2011. On the one hand, HFSPO commits 117.76 will be over 121 million USD, assuming that million USD for Program activities in FY 2011 and outstanding contributions from India and Italy are beyond, including operational costs. On the other received. The equilibrium between income and hand, HFSPO expects to receive 55.83 million USD expenditure shows that HFSPO is operated on a in MSPs’ contributions for FY 2011. Together with sound financial basis. resources from past contributions, interest and

Table 4-9: Overview of HFSPO budget for FY 2011 including all commitments for future years

BUDGET BUDGET BUDGET Canberra BUDGET EXPENDITURES 2011 2011 INCOME 2011 IGC - USD 2011 in m LC in m USD in m LC in m LC in m USD* USD 1. CONTRIBUTIONS n.a. 61.0 55.83 1.HFSP OPERATIONS EUR 3.35 4.47 Australia USD 0.62 0.62 0.62 2. PROGRAM ACTIVITIES USD 57.89 Canada CAD 1.61 1.61 1.61 Program Grants 25.20 25.20 European Union EUR 4.32 5.76 5.76 Young Investigators 9.55 9.55 France (indicative figures) EUR 1.55 2.07 2.07 Fellowships 17.51 17.51 Germany EUR 3.80 5.06 5.06 Career Development Awards 4.80 4.80 India USD 0.91 0.91 0.91 Italy EUR 0.82 1.09 1.09 Awardees meeting 0.25 0.25 Japan USD 24.77 29.52 24.77 Program meetings (Review cycle) 0.40 0.40 Outreach activities - Korea USD 0.72 0.72 0.72 0.14 0.14 Alumni network New Zealand USD 0.12 0.12 0.12 Nakasone Award 0.04 0.04 Norway USD 0.56 0.56 0.56 3. TO BE PAID AS OF 10/3/11 1.25 Switzerland CHF 0.76 0.66 0.66 CDA 2008-2009-2010 0.80 0.80 UK GBP 1.26 1.94 1.94 LT 2010 0.03 0.03 USA USD 9.93 10.33 9.93 Office costs for FY 2010 0.43 0.43 2. INTEREST AND 4. COMMITTED FUNDS BEYOND FY 54.15 54.15 CAPITAL GAIN USD 0.50 Program Grants 23.95 23.95 3. TREASURY as of Young Investigators 10.15 10.15 17/02/2011 USD 62.42 4. CONTRIBUTIONS Fellowships 16.85 16.85 TO BE RECEIVED Career Development Awards 3.20 3.20 (Italy FY 2009 and India FY 2010) USD 2.31 TOTAL EXPENSES + 117.76 TOTAL INCOME + ASSETS USD 121.06 COMMITTED FUNDS

BALANCE (positive) 3.30

GRAND TOTAL USD 121.06 GRAND TOTAL 121.06

* Budget rate

Notes on FY 2010 accounts FY 2010 accounts Table 4-9 shows the accounts for FY 2010, consolidated They follow the French regulations (GAAP) applicable in EUR, which have been prepared by the chartered to not-for-profit organisations. Legal accounts are accountants KPMG-SEGEC. Price Waterhouse Coopers consolidated and stated in EUR. The currency of audited and certified these accounts. HFSPO’s legal consolidation used for HFSPO’s internal reporting, accounts are reported on an accrual basis. Notes on including this annual report, is the USD.

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Appendix

Appendix

A.1 History of the Program A.2 Joint Communiqué of the Intergovernmental Conference on the Human Frontier Science Program, Canberra, 28 May 2010 A.3 Summary of decisions of the Board of Trustees in 2010 A.4 Long-Term and Cross-Disciplinary Fellowships awarded in 2010 A.5 Short-Term Fellowships awarded in 2010 A.6 Career Development Awards made in 2010 A.7 Research Grants awarded in 2010

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procedures. Intergovernmental conferences were held in June and July 1989 in Tokyo and Berlin, respectively, which led to endorsement of the plan by the A.1 participating governments. It was agreed to implement the HFSP for an initial experimental phase of 3 years.

The Secretariat of the Program, the International Human Frontier Science Program Organization, was founded in October 1989 in Strasbourg, France. The first President of the Program was Ambassador Miyazaki (Japan), the first Chairman of the Council of Scientists was Dr. Edward Rall (US) and the first Secretary General was Sir James Gowans, former HISTORY OF THE Secretary of the Medical Research Council, UK. 1990 The peer review process was established and PROGRAM the first awards were made in March.

A1.2 Further development of the Program

Intergovernmental Conferences bring together representatives of the Management Supporting A1.1 Beginnings Parties, i.e. those countries that support the Program directly, plus the European Union, representing the 1986 A feasibility study was carried out by leading remaining EU countries, to discuss overall policy and Japanese scientists under the auspices of the Japanese strategy. Since 2004, they also establish an indicative Prime Minister's Council for Science of Technology, financial framework for the following three years. to explore possible means to encourage international collaboration in basic research. 1st Intergovernmental Conference, Tokyo, Japan, January 1992: This conference recognised the 1987 Discussion was expanded to include scientists achievements made in the initial phase of the from the G7 summit nations and the European Union, Program and the desirability of continuing the HFSP. resulting in the “London Wise Men's Conference” in It was decided to carry out a general review of the April 1987, which endorsed the suggestion. program from both scientific and organisational Prime Minister Nakasone of Japan proposed the Human standpoints. Frontier Science Program at the Venice Economic nd Summit in June. The economic Summit partners and 2 Intergovernmental Conference, Washington, DC, the Chairman of the European Community welcomed USA, May 1997: This conference recognised the the initiative and activities aimed at implementing it achievements made in the initial phase of the as soon as possible were started. Program and the desirability of continuing the HFSP. It was decided to carry out a general review of the 1988 Further international talks were held from program from both scientific and organisational November 1987 to March 1988 in the form of an standpoints International HFSP Feasibility Study Committee, which culminated in April 1988 in the “Bonn Wise 3rd Intergovernmental Conference, Berlin, Germany, Men's conference” - this established an outline of the June 2002: The MSPs agreed to the continuation of program activities and defined the general scientific HFSP for a further five years on the basis of its areas and types of activity to be supported. scientific value and the implementation of a number of initiatives introduced by the Secretary General. Prime Minister Takeshita of Japan reported the A working group was set up to consider the future conclusions of the international feasibility study at finances, status and scope of the Program. the Toronto Economic Summit in June. The assembled Heads of State welcomed the proposal for 4th Intergovernmental Conference, Bern, Switzerland, implementation in the near future. June 2004: The delegates agreed upon a general indicative financial framework for 2005-2007 in order 1989 An International Scientists Committee, which to reach a total budget of 60 million USD and a 50:50 had started work in 1987, gave further shape to the distribution of contributions from Japan and the other Program, defining its organization and the details of countries. An annual increase was recommended to its program activities, research areas and selection maintain the awarding capacity of the Program.

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5th Intergovernmental Conference, Ottawa, Canada, the success of the initiatives since 2000 and a June 2007: The representatives agreed on an bibliometric analysis of awardees’ publications. indicative three year budgetary plan 2008-2010 and A further study of commercialization resulting from endorsed the Board recommendation of March 2007 HFSP funded research was carried out at the request that an annual minimum contribution be required of of the Ministry of Trade, Economy and Industry, Japan. any new MSP. A1.5 Leadership and management 6th Intergovernmental Conference, Canberra, Australia, May 2010: The representatives recognised The MSPs nominate representatives to the Board of the success of HFSP in setting new paradigms for Trustees to take responsibility for the management research and in funding excellent individual and of the Program in collaboration with the Council of collaborative projects over a 20 year period. As the Scientists. A President and two Vice-Presidents are Program enters a new phase of its development, elected by the members from among the Trustees for representatives asked the Board to develop a new a three-year term. The Board of Trustees appoints a financial framework for consideration at the next IGC. Secretary General for a term of three years to execute For the period 2011-2013, an indicative financial the Program in accordance with the decisions of the framework was agreed. Board of Trustees and the Council of Scientists.

A1.3 Membership of HFSPO President of the Board of Trustees Hiromichi MIYAZAKI (Japan) November 1989 – March 1995 HFSPO was established at the initiative of the Japanese Kozo IIZUKA (Japan) April 1995 – March 2000 government, led by Prime Minister Nakasone. Masao ITO (Japan) April 2000 – March 2009 The founding MSPs were Canada, France, Germany, Akito ARIMA (Japan) April 2009 to present European Union, Italy, Japan, the UK and the USA. Switzerland took up membership in 1991. At the Chair of the Council of Scientists 3rd Intergovernmental Conference, Berlin, 2002, MSPs Edward RALL (USA): agreed to take active steps to expand the membership of March 1990 (2nd meeting) to March 1993 (8th meeting), HFSPO to enhance the intercontinental balance of the Klaus-Peter HOFFMANN (Germany) Program and promote international collaboration. The November 1993 (9th meeting) to March 1995 (12th meeting) Pierre CHAMBON (France) Guidelines for membership were subsequently revised March 1996 (13th meeting) and March 1997 (14th meeting) and the Board accepted the following new members: Albert AGUAYO (Canada) March 1998 (15th meeting) and March 1999 (16th meeting) 2004 Australia and Republic of Korea Arturo FALASCHI (Italy) 2006 New Zealand and India March 2000 (17th meeting) and March 2001 (18th meeting) 2008 Norway Pierre MAGISTRETTI (Switzerland) March 2002 (19th meeting) and March 2003 (20th meeting) A1.4 Reviews of HFSP Heinrich BETZ (Germany) March 2004 (21st meeting) Joachim SEELIG (Switzerland) A number of reviews have been carried out at the March 2005 (22nd meeting) and March 2006 (23rd meeting) request of the MSPs. Rudi BALLING (Germany) March 2007 (24th meeting) 1996 General Review: a questionnaire based review, Paul LASKO (Canada) with comments by an expert scientific panel. March 2008 (25th meeting) to March 2010 (27th meeting) Rae SILVER (USA) 2001 Second General Review: a questionnaire based March 2011 (28th meeting) review, with a bibliometric analysis. Secretary General James GOWANS (UK) November 1989 – March 1993 2006 Review of the Human Frontier Program’s Michel CUÉNOD (Switzerland) April 1993 – March 2000 Initiatives 2000-2005: a questionnaire based review to Torsten WIESEL (USA) April 2000 – June 2009 evaluate the success of the initiatives introduced Ernst-Ludwig WINNACKER (Germany) July 2009 to present under the leadership of Secretary General, Torsten Wiesel.

2007 Report of the expert review panel on HFSP: an additional review by a panel of eminent scientists, who were invited to comment on the 2006 report and to identify issues for further evaluation.

2010 Review of the Human Frontier Science Program: a questionnaire based review to evaluate

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b) Representatives agree to commit to continue the A.2 support of the Program and to ensure the future success of HFSP by maintaining the competi- tiveness of its grants and support for exceptional scientists.

Paragraph 2 : Finances a) Representatives acknowledge and commend the lead role of Japan in supporting HFSP.Japan’s vision and its financial support over the past 20 years have ensured that the Program continues to have profound impacts in extending the frontiers of the JOINT COMMUNIQUÉ life sciences. b) Representatives agree to the proposed respective OF THE contributions for the period 2011-2013 as set out in the Annex. INTERGOVERNMENTAL c) Representatives are pleased to note that an equal match between the contribution of Japan and that CONFERENCE ON THE of other MSPs has been achieved. d) Representatives note that this Program, 20 years HUMAN FRONTIER after its foundation, is now entering a new phase of its development. Therefore, representatives request SCIENCE PROGRAM, the HFSPO Board of Trustees to develop a new financial framework based on clearly defined CANBERRA, principles. The IGC asks the Board to establish, as soon as possible, a small working group with clear 28 MAY 2010 Terms of Reference to develop such a framework. The IGC expects an IGC working party to consider the Board recommendations no later than March Representatives of the Management Supporting 2012. Parties (MSPs) of Australia, Canada, France, e) MSPs are encouraged to continue to increase their Germany, Italy, Japan, the Republic of Korea, New contributions so that the overall proportion of Zealand, Switzerland, the United Kingdom of non-Japanese contributions rises steadily over the Great Britain and Northern Ireland, the United years. States of America and of the European Union Paragraph 3 : New membership met at an Intergovernmental Conference (IGC) a) Representatives welcome the membership of on 28 May 2010 in Canberra, Australia, to review Norway as approved by the Board at its meeting in the progress made and to discuss the future of March 2008. the Human Frontier Science Program (HFSP). b) Representatives agree that the organisation should continue to encourage potentially interested parties Paragraph 1 : Continuation of the Human Frontier to apply for membership of HFSP, subject to the Science Program quality and capacity of fundamental biological a) Representatives recognise and applaud the success research conducted by that country, and by its of the HFSP in setting new paradigms in willingness and ability to support the HFSP international research and in supporting financially. exceptional research and fellows over a 20-year c) Negotiations with new countries regarding period. They note with approval the recent positive membership should be on the basis of the new external evaluation of the Program, in particular funding framework the clear success of the scientific programs in d) Representatives note that the contributions of any achieving their aim of stimulating interdisciplinary new members are to be added to the total amount interactions and supporting early career scientists. contributed by the other MSPs. The quality of the output is clearly well above other high impact comparators. The evaluation recognised Paragraph 4 : Next Meeting that HFSP continues to provide opportunities to a) Representatives expect an IGC to be held in order link knowledge areas in novel ways and that the to agree on the new financial framework before Program is more than ever avant-garde among the end of 2012. MSP contributions under the new funding programs globally. framework are to be negotiated in 2013.

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ANNEX

Canberra budgetary guidelines 2011-2013 (in k local currencies)

MSP Currency Budget FY 2011 Budget FY 2012 Budget FY 2013 Australia USD 622 647 673 Canada CAD 1 611 1 675 1 742 EU EUR 4 319 4 492 4 672 France** EUR 1 553 ** 1 615 ** 1 679 ** Germany EUR 3 795 3 947 4 105 India USD 914 951 989 Italy EUR 816 849 883 Japan* USD 29 523 * 29 523 * 29 523 * New Zealand USD 118 123 128 Norway USD 563 585 608 Republic of Korea USD 722 751 781 Switzerland CHF 757 787 818 UK GBP 1 258 1 309 1 361 USA USD 10 327 10 740 11 170

* Japan: a review of the program's performance in Japan will be conducted. This amount is subject to change, depending on its results. ** France: indicative figures The percentage contribution of Japan is 48.4% (FY 2011), 47.4% (FY 2012) and 46.5% (FY 2013). 1 USD=0.75 EUR, 1 CAD, 1.14 CHF and 0.65 GBP

Australia Canada European Union Prof Warwick ANDERSON (Chair of the Conference) Dr Alain BEAUDET Dr Bernard MULLIGAN

France Germany India Dr Kaddour RAISSI Dr Ulrich SCHLÜTER Prof Vijay RAGHAVAN

Italy Japan New Zealand Prof Piergiorgio STRATA Mr Itaru WATANABE Prof Graeme FRASER

Norway Republic of Korea Switzerland Director Anders HANNEBORG Mr Kidong SONG Dr Isabella BERETTA

United Kingdom United States of America Dr Mark PALMER Ms Vanessa RICHARDSON

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A.3

SUMMARY OF DECISIONS OF THE BOARD OF TRUSTEES IN 2010

44th BOARD MEETING (MARCH 2011)

The Board approved the following awards for funding: The Board agreed that the scientific misconduct policy 22 Program Grants (with 2 on the reserve list), statement on the HFSP web site should state that 11 Young Investigator Grants, 76 Long-Term HFSP expects applicants to adhere to the most Fellowships (with 11 on the reserve list), 9 Cross- stringent international criteria of good scientific Disciplinary Fellowships (with 4 on the reserve list) conduct in preparing their application. In addition, and 8 Career Development Awards (with 2 on the links to sources of information about good scientific reserve list). practice will be provided.

To enable the Council to better fulfil its statutory role The Board agreed to update the bylaws to make them as an advisory body to the Board, the Board agreed consistent with French law and to avoid modification to move the Council meeting to the Awardees of the bylaws every time OECD regulations applicable Meeting for a three-year trial period. to HFSP are updated. Any updates will be reviewed by the Budget and Finance Committee and Since the Awardees meeting is incompatible with the communicated to the Board. CDA review cycle, it was agreed to relieve the Council of responsibility for the CDA review and to establish Dr. Palmer and Dr. Rockey were unanimously elected a small review committee for this purpose. to serve as Vice-Presidents of the Board.

In order to maximise opportunities for career The Board approved the program activity plan and development, the Board agreed that CDA holders may budget for FY 2011. set up their independent laboratory either in the home country or in any HFSP member country other The Board approved the Auditors’ Report for FY 2009. than the original host country of the HFSP fellowship. The Board approved the appointment of The Board approved the selection of Dr. Michael Mr. Patrick Pierrat (France), Mr. Phat Do (Canada) and Elowitz, California Institute of Technology, as the Mr. Hideki Sasaki (Japan) as internal auditors for a recipient of the 2011 HFSP Nakasone Award. term of one year.

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A.4

LONG-TERM AND CROSS-DISCIPLINARY FELLOWSHIPS AWARDED IN 2010

1. Long-Term Fellowships1

Name Nationality Host institute Host country

ABOU-KHALIL Rana LEBANON Massachusetts General Hospital, Boston USA ALABERT Constance FRANCE Copenhagen University DENMARK AMUNTS Alexey ISRAEL MRC Laboratory of Molecular Biology, Cambridge UK BERTET Claire FRANCE New York University USA BIELING Peter GERMANY University of California, San Francisco USA BLANCO AGUDO Raquel SPAIN London Research Institute UK BROWN Andre CANADA MRC Laboratory of Molecular Biology, Cambridge UK BUDZOWSKA Magdalena POLAND Harvard Medical School, Boston USA CANDE Jessica USA Institut de Biologie du Développement de Marseille-Luminy FRANCE CANTONE Irene ITALY Imperial College London UK CRAGNOLINI Juan José ARGENTINA/ITALY Whitehead Institute for Biomedical Research, Boston USA DASGUPTA Shamik INDIA University of Oxford UK DE Subhajyoti INDIA Memorial Sloan-Kettering Cancer Center, New York USA DIMITROV Ariane FRANCE Max-Planck-Institute of Molecular Cell Biology and GERMANY Genetics, Dresden DUNLEAVY Elaine IRELAND Lawrence Berkeley National Laboratory USA ELYADA Yishai ISRAEL Duke University, Durham USA GEBHARDT Christof GERMANY Harvard University, Cambridge USA GIELEN Marc FRANCE University College of London UK HILF Ricarda GERMANY Oregon Health and Science University, Portland USA IOVINO Nicola ITALY Institut de Génétique Humaine, Montpellier FRANCE ITZKOVITZ Shalev ISRAEL Massachusetts Institute of Technology, Cambridge USA JACOBS Frank NETHERLANDS University of California, Santa Cruz USA JIN Mi Sun KOREA Purdue University, West Lafayette USA JOESCH KROTKI Maximilian AUSTRIA/CHILE/ Harvard University, Boston USA GERMANY JOSHUA Mati ISRAEL/USA University of California, San Francisco USA KADAJA Meelis ESTONIA The Rockefeller University, New York USA KANG Hae Joo NEW ZEALAND Imperial College London UK KAWAKAMI Takashi JAPAN Massachusetts Institute of Technology, Cambridge USA

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Name Nationality Host institute Host country

KELLER Georg Switzerland Max Planck Institute of Neurobiology, Martinsried GERMANY KIM Jin Hee KOREA Ohio State University, Columbus USA KLINGE Sebastian GERMANY Institute for Molecular Biology and Biophysics, Zurich SWITZERLAND KOENIG Daniel USA Max Planck Institute of Developmental Biology, GERMANY Tubingen KOZIOL Magdalena GERMANY Harvard University, Cambridge USA KUBO Fumi JAPAN University of California, San Francisco USA KYRIAKATOS Alexandros GREECE Ecole Polytechnique Fédérale de Lausanne SWITZERLAND LAEMMERMANN Tim GERMANY National Institutes of Health, Bethesda USA LAGHA Mounia ALGERIA/FRANCE University of California, Berkeley USA LORINCZ Magor ROMANIA Instituto Gulbenkian de Ciência, Oeiras PORTUGAL MA Hansong CHINA University of California, San Francisco USA MACAULEY Matthew CANADA The Scripps Research Institute, La Jolla USA MARSH Joseph CANADA MRC Laboratory of Molecular Biology, Cambridge UK MARTELLO Graziano ITALY University of Cambridge UK MASSARWA Rada ISRAEL University of Colorado at Denver, Aurora USA MATHIEU Johannes GERMANY Boyce Thompson Institute for Plant Research, Ithaca USA MATOS Joao PORTUGAL Cancer Research UK, London Research Institute UK MCMENIMAN Conor AUSTRALIA The Rockefeller University, New York USA MIAO Yansong CHINA University of California, Berkeley USA NAGAI Shigeki JAPAN Stanford University USA NARBONNE Patrick CANADA University of Cambridge UK NEUMULLER Ralph AUSTRIA Harvard Medical School, Boston USA NITYANANDA Vivek INDIA University of London UK NOMA Akiko JAPAN University of Massachusetts, Worcester USA PAULI Andrea GERMANY Harvard University, Cambridge USA PENNINGS Pleuni NETHERLANDS Harvard University, Boston USA PHNG Li-Kun MALAYSIA European Molecular Biology Laboratory, Heidelberg GERMANY RAMIALISON Mirana FRANCE/ Victor Chang Cardiac Research Institute, Sydney AUSTRALIA MADAGASCAR RAND Kasper DENMARK University of Lausanne SWITZERLAND RIVLIN-ETZION Michal FRANCE/ISRAEL University of California, Berkeley USA SCHERZ-SHOUVAL Ruth ISRAEL Massachusetts Institute of Technology, Cambridge USA SCHULZ Edda GERMANY Institut Curie, Paris FRANCE SIEGEL Tim Nicolai GERMANY Institut Pasteur, Paris FRANCE STERN-GINOSSAR Noam ISRAEL University of California, San Francisco USA THOMA Claudio SWITZERLAND Harvard Medical School, Boston USA VERNES Sonja AUSTRALIA/ Research Institute of Molecular Pathology, Vienna AUSTRIA NETHERLANDS VERWEIJ Alexandra PORTUGAL John Innes Centre, Norwich UK VITRE Benjamin FRANCE Ludwig Institute for Cancer Research, La Jolla USA WAI Timothy CANADA/FRANCE Institute for Genetics, Cologne GERMANY WILLIAMS Philip USA Technical University, Munich GERMANY XUE Huiling CHINA Yale University, New Haven USA YAMAGATA Kazuyuki JAPAN Children's Hospital, Boston USA YAN Jing CHINA Stanford University USA YAN Zhiqiang CHINA University of California, San Francisco USA YUN Kijun KOREA Johns Hopkins University, Baltimore USA ZANETTI Giulia ITALY University of California, Berkeley USA ZEQIRAJ Elton UK Mount Sinai Hospital, Toronto CANADA

1 These Long-Term Fellowships were initiated during FY 2010. For a list of fellows awarded in 2011, see HFSP web site (http;//www.hfsp.org)

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2. Cross-Disciplinary Fellowships2

Name Nationality Host institute Host country

BEATUS Tsevi ISRAEL Cornell University, Ithaca USA BORNSCHLÖGL Thomas GERMANY Institut Curie, Paris FRANCE CARBONETTO Peter CANADA/USA University of Chicago USA HADDAD Rafi ISRAEL Harvard University, Boston USA HERMANS Thomas BELGIUM Northwestern University, Evanston USA KONER Apurba Lal INDIA Oxford University UK LAAN Liedewij NETHERLANDS Harvard University, Cambridge USA POTAPOV Alexey RUSSIA National Institutes of Health, Bethesda USA TAL Assaf ISRAEL/USA New York University USA VAN TEEFFELEN Sven GERMANY Princeton University USA WITTE Christopher AUSTRALIA Leibniz Institute for Molecular Pharmacology, Berlin GERMANY

2 These Cross-Disciplinary Fellowships were initiated during FY 2010. For a list of fellows awarded in 2011, see HFSP web site (http;//www.hfsp.org) A.5

SHORT-TERM FELLOWSHIPS AWARDED IN 20103

Name Nationality Host institute Host country

BIRKET Matthew UK Department of Anatomy and Embryology, Leiden NETHERLANDS University DORÉ Kim CANADA Marine Biological Laboratory, Woods Hole USA HARLEY Brendan USA Royal College of Surgeons, Dublin IRELAND MA Hoi Tang HONG KONG Clare Hall Laboratories, London Research Institute UK WINDISCHBERGER Christian AUSTRIA Wellcome Trust Centre for Neuroimaging, UK University College London

3 These Short-Term Fellowships were awarded to applicants in 2009.

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A.6

CAREER DEVELOPMENT AWARDS MADE IN 20104

Name Nationality Institute of CDA Country of CDA

BEN-AROYA Shay Israel Bar-Ilan University, Ramat-Gan Israel CHTANOVA Tatyana Australia Garvan Institute of Medical Research, Sydney Australia EGO-STENGEL Valérie France Institut de Neurobiologie Alfred Fessard, Gif sur Yvette France ELDAR Avigdor Israel Tel-Aviv University Israel FÜRTHAUER Maximilian Austria University of Nice France HSU Shang-Te Danny Taiwan National Tsing-Hua University, Hsinchu Taiwan HUISKEN Jan Germany MPI of Molecular Cell Biology and Genetics, Dresden Germany LINDING Rune Denmark Technical University of Denmark, Lyngby Denmark MARGULIES David Israel Weizmann Institute of Science, Rehovot Israel NEALE Matthew UK University of Sussex, Falmer UK NISHINO Tatsuya Japan National Institute of Genetics, Mishima Japan PRICE Nicholas Australia Monash University, Melbourne Australia SCHMEING Thomas Martin Canada/USA McGill University, Montreal Canada SEITZ Hervé France CNRS / Université Paul-Sabatier, Toulouse France TEIS David Austria Biocenter, Medical University Innsbruck Austria VERMOT Julien France IGBMC, Illkirch France

4 These awards were initiated during FY 2010. For a list of the CDAs awarded in 2011, see the HFSP web site (http://www.hfsp.org/).

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A.7 A new stress-induced program of senescence and its multi-dimensional regulation NARITA Masashi, (Japan), UK OHBAYASHI Tetsuya, Japan

Characterization of light-dependent rhythmic processes in the marine environment TESSMAR-RAIBLE Kristin, (Germany), Austria FALCIATORE Angela, Italy ISHIKAWA Tomoko, Japan RESEARCH GRANTS OLIVERI Paola, (Italy), UK 5 AWARDED IN 2010 2. PROGRAM GRANTS

Note that nationality is given in brackets if different The calcified byssus of Anomia: a unique solution from country of laboratory to underwater adhesion BIRKEDAL Henrik, Denmark 1. YOUNG INVESTIGATORS WAITE Herbert, USA

Nanoelectronic biosensors: novel tools to watch Analysis of “cytoplasmic freezing” – preserving individual enzymes at work cellular architecture BLANK Kerstin, (Germany), Netherlands BRUNNER Damian, (Switzerland), Germany MINOT Ethan, USA FLORIN Ernst-Ludwig, (Germany), USA HOENGER Andreas, (Switzerland), USA Fundamental principles of dynamic running gaits DALEY Monica A, (USA), UK A microfluidic, small molecule approach to HURST Jonathan, USA perturbation of the pluripotency network Stem cell differentiation in 3D nanostructured CHAMBERS Ian, UK environments LEE Luke P., USA ENGLER Adam, USA SCHROEDER Timm, Germany BATTAGLIA Giuseppe, (Italy), UK WANDLESS Thomas, USA

Molecular architecture and mechanical properties Dissecting the molecular mechanisms regulating of the kinetochore: a biophysical approach somatic cell reprogramming GREGAN Juraj, (Slovakia), Austria COSMA Maria Pia, Italy CIMINI Daniela, (Italy), USA CALIFANO Andrea, (Italy), USA TOLIC-NORRELYKKE Iva M., (Croatia), Germany Central auditory processing: from single cells to Mechanochemistry of DNA strand separation by perception and learning of complex sounds helicases DOUPE Allison, (Canada),USA KOVACS Mihaly, Hungary BIALEK William S., USA NEUMAN Keir, USA WILD John Martin, New Zealand

Towards an integrated model of phenotypic Spatiotemporal control of neuronal activity with evolution: the genetic architecture of network holographic patterned illumination dynamics EMILIANI Valentina, (Italy), France LANDRY Christian, Canada CURTIS Jennifer, USA MOHAN Madan Babu, (India), UK ISACOFF Ehud Y., USA RIFKIN Scott, USA PEDARZANI Paola, (Italy),UK

Spatial control of the mitotic checkpoint clock - Mechanistic analysis of neuronal circuit structure dissecting the role of a spindle matrix and function MAIATO Helder, Portugal FRIEDRICH Rainer, (Germany), Switzerland CHEESEMAN Iain, USA SEUNG H. Sebastian, USA WEISS Matthias, Germany YOSHIHARA Yoshihiro, Japan

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The regulation of growth as a driving force for Deliberative decision-making in rats patterning and regeneration REDISH A. David, USA GALLIOT Brigitte, Switzerland DUDCHENKO Paul, (USA), UK DEUTSCH Andreas, Germany LAUWEREYNS Jan, (Belgium), New Zealand IRVINE Kenneth D., USA TSUDA Ichiro, Japan MORATA PÉREZ Gines, Spain WOOD Emma, UK TANAKA Elly, (USA), Germany An interaction map of C. elegans dauer pheromone Optogenetics for small G-proteins and protein compoments and chemoreceptors kinases in neuroscience SENGUPTA Piali, (India), USA KASAI Haruo, Japan CLARDY Jon, USA HAHN Klaus, USA TOUHARA Kazushige, Japan KUHLMAN Brian, USA Role of genetic interactions and recombination in Structure of nascent peptides and kinetic control experimental evolution of Caenorhabditis elegans of co-translational folding on the ribosome TEOTONIO Henrique, Portugal KOMAR Anton, (Russia), USA ROCKMAN Matthew, USA RODNINA Marina, Germany SHRAIMAN Boris, USA SCHWALBE Harald, Germany An interdisciplinary approach to understand the Odor recognition in natural environments: Bayesian development and evolution of leaf shapes inference from insects to mammals TSIANTIS Miltos, (Greece), UK MAINEN Zachary, (USA), Portugal PRUSINKIEWICZ Przemyslaw, Canada LOUIS Matthieu, (Belgium), Spain POUGET Alexandre, (France), USA Chiral effects in DNA supercoilings VAN DER HEIJDEN Gert, (Netherlands), UK Information processing by signal transduction and KORNYSHEV Alexei, (Russia), UK gene regulatory networks in mammalian cells WUITE Gijs J.L., Netherlands MARTINEZ-ARIAS Alfonso, (Spain), UK ZECHIEDRICH Lynn, USA GUNAWARDENA Jeremy, (UK), USA HADJANTONAKIS Anna-Katerina, (UK), USA Synthetic Biology of cell division: reconstructing the bacterial division machinery in the test tube Dynamical coordination in a multi-domain, peptide VICENTE Miguel, Spain antibiotic mega-synthetase MARGOLIN William, USA MOOTZ Henning, Germany RIVAS German, Spain KOMATSUZAKI Tamiki, Japan SCHWILLE Petra, Germany YANG Haw, (Taiwan), USA Viral docking and maturation in whole bacterial Optical interrogation of motor cortex to provide cells at near atomic resolution and in 4 dimensions insight into neuronal control of movement VIOLLIER Patrick, Switzerland MURPHY Timothy H., (USA), Canada HOWARD Martin, UK BOYDEN Edward, USA WRIGHT Elizabeth, USA MARTIN Kevan A. C., (UK), Switzerland Role of genetic interactions and recombination in Nanoscale photoactivation and imaging of synaptic Cycle-quant: defining cell cycle progression and physiology responses to perturbations NÄGERL Valentin, (Germany), France WOLTHUIS Rob, Netherlands HELL Stefan, Germany CARPENTER Anne, USA LI Wen-Hong, USA CHANG Young-Tae, (Korea), Singapore

Mitotic spindles in nematodes: from comparative 5 These awards were initiated during FY 2010. For a list of grant biophysics to evolutionary biology teams awarded in 2011, see the HFSP web site NEEDLEMAN Daniel, USA (http://www.hfsp.org/). DELATTRE Marie, France MÜLLER-REICHERT Thomas, Germany

Spatio-temporal Rho GTPase signaling to the cytoskeleton during neuronal development and repair PERTZ Olivier, Switzerland DANUSER Gaudenz, (Switzerland), USA JEON Noo Li, (USA), Korea

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— 82 — HUMAN FRONTIER SCIENCE PROGRAM

The Human Frontier Science Program is unique, supporting international collaboration to undertake innovative, risky, basic research at the frontiers of the life sciences. Special emphasis is HFSPO given to the support and training of independent young Registre des Associations de Strasbourg investigators, beginning at the postdoctoral level. The Program is Volume 58- Folio 99 Achevé d’imprimé en juillet deux mille onze implemented by an international organisation, supported sur les presses de Faber financially by Australia, Canada, France, Germany, India, Italy, Japan, the Republic of Korea, New Zealand, Norway, Switzerland, The International Human Frontier Science Program Organization (HFSPO) the United Kingdom, the United States of America, and the 12 quai Saint Jean European Union. Since 1990, nearly 6000 awards have been made BP 10034 to researchers from more than 70 countries. Of these, 16 HFSP 67080 Strasbourg CEDEX France awardees have gone on to receive the Nobel Prize. Fax. +33 (0)3 88 32 88 97 e-mail: [email protected] Web site: www.hfsp.org Japanese web site: http://jhfsp.jsf.or.jp

© Photos: HFSPO thanks Rae Silver, Frederick MacKintosh and Michael Elowitz for supplementary photos, in addition to those provided by Sandro Weltin (p. 7, 17, 27, 39, 53), Toru Nakahara (p.10), Musashi University (p. 12), BNP Paribas Real Estate (p.15), the Ravi Studio, Thiruvananthapuram (p. 9, 41) and those taken from the website of the Max Planck Institute of Molecular Cell Biology and Genetics, Dresden (p. 25), iStockphoto (cover), iStockphoto (p.16), iStockphoto (p.26), shutterstock/ arteretum (p.6), shutterstock/ Michael Pettigrew (p.52), shutterstock/ Nancy Kennedy (p.68). 0 1 0 2 Acknowledgements T

HFSPO is grateful for the support of the following organizations: O R

Australia R E P

National Health and Medical Research Council (NHMRC) L

Canada A Canadian Institute of Health Research (CIHR) Natural Sciences and Engineering Research Council (NSERC)

European Union N U European Commission - A Directorate General Information Society (DG INFSO) European Commission - Directorate General Research (DG RESEARCH)

France Communauté Urbaine de Strasbourg (CUS) Ministère des Affaires Etrangères et Européennes (MAEE) Ministère de l’Enseignement Supérieur et de la Recherche (MESR) Région Alsace

Germany Federal Ministry of Education and Research (BMBF)

India Department of Biotechnology (DBT), Ministry of Science and Technology

Italy Ministry of Education, University and Research (CNR)

Japan Ministry for Economy, Trade and Industry (METI) Ministry of Education, Culture, Sports, Science and Technology (MEXT)

Republic of Korea Ministry of Education, Science and Technology (MEST)

New Zealand Health Research Council (HRC)

Norway Research Council of Norway (RCN)

Switzerland State Secretariat for Education and Research (SER)

United Kingdom The International Human Frontier Science Biotechnology and Biological Sciences Research Program Organization (HFSPO) Council (BBSRC) 12 quai Saint Jean - BP 10034 Medical Research Council (MRC) 67080 Strasbourg CEDEX - France Fax. +33 (0)3 88 32 88 97 United States of America e-mail: [email protected] National Institutes of Health (NIH) Web site: www.hfsp.org National Science Foundation (NSF) Japanese web site: http://jhfsp.jsf.or.jp