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Conference Ontyph Id 10th INTERNATIONAL CONFERENCE ON TYPH ID & OTHER INVASIVE SALMONELLOSES April 4–6, 2017 | Kampala, Uganda 10th INTERNATIONAL CONFERENCE ON TYPH ID & OTHER INVASIVE SALMONELLOSES WELCOME April 4–6, 2017 | Kampala, Uganda THE WORLD NEEDS ACTION ON TYPHOID — BUILDING EVIDENCE AND REFINING STRATEGIES The Coalition against Typhoid, housed at the Sabin Vaccine Institute, welcomes you to the 10th International Conference on Typhoid and Other Invasive Salmonelloses. We are pleased to provide a forum for more than 300 researchers, policy makers, immunization managers and advocates to come together to share the latest developments and best strategies to reduce the burden of typhoid, paratyphoid and nontyphoidal salmonelloses (NTS) on communities around the world. The conference theme, “From Evidence to Action,” is timely as we prepare for the introduction of new typhoid conjugate vaccines. The research, evidence and ideas shared this week in Kampala will provide the foundation for global action against typhoid, paratyphoid and NTS. Together, we will review crucial developments to reduce the global burden of these diseases, including results from major surveillance projects in Africa and Asia, the potential of human infection models and strategies for countering antibiotic resistance. The program will also highlight outbreak control methods, exciting innovations in diagnostics, water, sanitation and hygiene strategies for prevention, and policy measures aimed at accelerating the implementation of these interventions. The coming availability of a new generation of typhoid conjugate vaccines makes this a pivotal moment for global action on typhoid. These promising new vaccines offer important advantages over prior vaccines, including longer duration of protection, the ability to protect young children, and the potential for administration with other vaccines in routine immunization of infants. As Salmonella bacteria become increasingly resistant to available antibiotic treatments, conjugate vaccines have the potential to dramatically reduce the burden of typhoid around the world and consequently help to prevent the occurrence of antibiotic resistance. Working together to share research and generate evidence to shape solutions is more important than ever. We thank you for joining us and extend our gratitude to the Bill & Melinda Gates Foundation for their generous support of this conference, the world’s only conference devoted to typhoid and other invasive salmonelloses. In addition, we would like to thank the Ministry of Health of the Republic of Uganda for their assistance and hospitality. We look forward to three days of discussion, debate and forging new partnerships in the fight against typhoid. Sincerely, Denise Garrett, MD, MSc Bruce Gellin, MD, MPH Amy Finan Vice President, Typhoid Programs President, Global Immunization Chief Executive Officer Sabin Vaccine Institute Sabin Vaccine Institute Sabin Vaccine Institute Director, Coalition against Typhoid #STOPTYPHOID 1 10th INTERNATIONAL CONFERENCE ON TYPH ID & OTHER INVASIVE SALMONELLOSES WELCOME April 4–6, 2017 | Kampala, Uganda TABLE OF CONTENTS 4 Scientific Organizing Committee 5 Agenda 13 Program 45 Poster Abstracts 87 Conference Information 91 Index THANK YOU TO OUR SPONSORS 10th INTERNATIONAL CONFERENCE ON TYPH ID & OTHER INVASIVE SALMONELLOSES April 4–6, 2017 | Kampala, Uganda SCIENTIFIC ORGANIZING COMMITTEE Adwoa Bentsi-Enchill World Health Organization Zulfiqar Bhutta Aga Khan University Robert Breiman Emory University John Crump University of Otago Hubert Endtz Fondation Mérieux Denise Garrett Sabin Vaccine Institute Melita Gordon University of Liverpool Bernard Lubwama Ministry of Health, Uganda Florian Marks International Vaccine Institute Mark Miller National Institutes of Health Eric Mintz Centers for Disease Control and Prevention Kathy Neuzil University of Maryland School of Medicine Andrew Pollard University of Oxford Samir Saha Child Health Research Foundation Dipika Sur Translational Health Science and Technology Institute ABSTRACT REVIEW PANEL Jason Andrews Stanford University Isaac Bogoch University of Toronto Kashmira Date Centers for Disease Control and Prevention Gordon Dougan Wellcome Trust Sanger Institute Brad Gessner Agence de Médecine Préventive Jan Jacobs Institute of Tropical Medicine Antwerp Gagandeep Kang Christian Medical College, Vellore Sam Kariuki Kenya Medical Research Institute Karen Kotloff University of Maryland School of Medicine Laura Martin GSK Vaccines Institute for Global Health Kim Mulholland London School of Tropical Medicine and Hygiene Ellis Owusu-Dabo Kwame Nkrumah University of Science and Technology Virginia Pitzer Yale School of Public Health Firdausi Qadri International Centre for Diarrhoeal Disease and Research, Bangladesh Farah Qamar Aga Khan University Jeff Stanaway Institute for Health Metrics and Evaluation 4 #STOPTYPHOID AGENDA 10th INTERNATIONAL CONFERENCE ON TYPH ID WELCOMEAGENDA & OTHER INVASIVE SALMONELLOSES April 4–6, 2017 | Kampala, Uganda TUESDAY, APRIL 4 08:30 – 08:35 Welcome Remarks Bruce Gellin, Sabin Vaccine Institute 08:35 – 08:40 Conference Opening Denise Garrett, Sabin Vaccine Institute Body of Evidence: Updates on Global Disease Burden 08:40 – 10:10 PLENARY SESSION MODERATED BY: Thomas Cherian (World Health Organization) & Melita Gordon (University of Liverpool) Looking to the Future: Control of Typhoid 08:40 – 08:55 Anita Zaidi, Bill & Melinda Gates Foundation in the Next Decade 08:55 – 09:10 Progress in Typhoid Fever Epidemiology John Crump, University of Otago Incidence, Presentation and Outcomes of Salmonella Cal MacLennan on behalf of the MAL055 09:10 – 09:25 Bacteraemia Among Young Children in Sub-Saharan RTS,S-AS01 Salmonella Ancillary Study Africa: MAL055 RTS,S-AS01 Salmonella Ancillary Study Enteric Fever Among Outbreaks in Africa: Same Old Foe Sam Kariuki, Kenya Medical 09:25 – 09:40 but Emerging New Challenges in Management Research Institute Clades of Salmonella Associated with Epidemics Nick Feasey, Liverpool School of Tropical 09:40 – 09:55 of Invasive Salmonella Disease Medicine 09:55 – 10:10 QUESTIONS AND DISCUSSION 10:10 – 10:30 Coffee Break and Posters The Devil you Know: Diagnosing and Detecting Enteric Fever 10:30 – 12:30 ORAL ABSTRACT SESSION MODERATED BY: Gagandeep Kang (Christian Medical College, Vellore) & Hubert Endtz (Fondation Mérieux) Evaluation of a New Real-Time PCR to Identify 10:30 – 10:45 S. Typhi, S. Paratyphi A and S. spp. from Patients Stephane Pouzol, Fondation Mérieux with Fever in Bangladesh Identification of a New Serodiagnostic Signature of 10:45 – 11:00 Thomas Darton, University of Oxford Acute Typhoid Fever Using Salmonella Proteome Arrays Antigen Discovery for Improved Diagnosis of Invasive Sara Saleh, Institute of Tropical Medicine, 11:00 – 11:15 Salmonellosis by Targeted Proteomics Antwerp Carriage of Salmonella Typhi Among Vendors Mark Bumano, Makerere University College 11:15 – 11:30 in Two Kampala Markets of Health Sciences Typhoid Outbreak Caused by Drinks Made David Oguttu, Uganda Public Health 11:30 – 11:45 from Contaminated Underground Water Sources Fellowship Program in Kampala, Uganda, January-March, 2015 Salmonella Typhi Bloodstream Infections Among Infants John Lusingu, National Institute 11:45 – 12:00 and Children, Korogwe District Hospital, Tanzania for Medical Research Typhoid Fever in Santiago, Chile: 12:00 – 12:15 Modern Insights Where Historical Data Meet Jillian Gauld, Institute for Disease Modeling Mathematical Modeling Salmonella Typhi Bactericidal Antibody Activity 12:15 – 12:30 is a Correlate of Disease Severity, but Not Protection Andrew Pollard, University of Oxford Against Typhoid Fever 12:30 – 13:30 Lunch and Posters 6 #STOPTYPHOID 10th INTERNATIONAL CONFERENCE ON TYPH ID & OTHER INVASIVE SALMONELLOSES WELCOMEAGENDA April 4–6, 2017 | Kampala, Uganda The Right Shot: Vaccine Session I 13:30 – 15:00 ORAL ABSTRACT SESSION MODERATED BY: John Clemens (International Centre for Diarrhoeal Disease Research, Bangladesh) & Laura Martin (GSK Vaccines Institute for Global Health) Creating a Sustainable Vaccine Landscape: Vinita Vishwanarayan, 13:30 – 13:45 Overcoming Barriers to Vaccine Development Clinton Health Access Initiative and Speed to Market Comparison of Strategies and Thresholds 13:45 – 14:00 for the Vi Conjugate Vaccine Against Typhoid Fever: Nathan Lo, Stanford University A Cost-Effectiveness Modeling Study Development of New Generation Monovalent Typhoid 14:00 – 14:15 Akshay Goel, Biological E Conjugate Vaccine: Vi-CRM197 Live Oral Typhoid Vaccine Ty21a Elicited Cross-Reactive Rezwanul Wahid, University of Maryland 14:15 – 14:30 Multifunctional IL-17A Producing T Cell Responses School of Medicine Against Salmonella enterica Serovars In Humans Exploring S. Typhi-Specific HLA-E-Restricted Immune Mark Rudolph, University of Maryland 14:30 – 14:45 Responses in Pediatric and Adult Ty21a Recipients School of Medicine Using Mass Cytometry Whole Genome Sequence Analysis of Salmonella Typhi 14:45 – 15:00 Isolated in Thailand Before and After the Introduction Zoe Dyson, University of Melbourne of a National Immunisation Program 15:00 – 15:30 Coffee Break and Posters Spotlight on Africa and Asia: Enteric Fever Surveillance 15:30 – 17:45 SYMPOSIUM SESSION CHAIRED BY: Robert Breiman (Emory University) & Megan Carey (Bill & Melinda Gates Foundation) Epidemiology and Disease Burden of Typhoid Fever 15:30 – 15:45 Florian Marks, International Vaccine Institute and iNTS Disease in Sub-Saharan Africa The Severe Typhoid Fever Surveillance in Africa
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