INDEX

Volume 146, October-December 1964

Acetazoleamide, influence of altitude on anticon- Atropine, compared with dicyclomine, 354 vulsant action, 160 effect on sympathetic ganglia, 335 3-Acetyl strophanthidin, effect on salivary potas- Autonomic ganglia, modification of transmission sium, 298 by drugs, 335 Acetyicholine, effect on myometriuxn, 313 Axeirod, J., see Glowinski, J., 48 effect on sympathetic ganlia, 335 see Snyder, S. H., 276 electrophoretic application to olfactory bulb, 16 excitation of muscle spindle afferent nerves, 344 BAL, see dimercaprol, 236 inhibition of egg deposition by a rotifer, 123 Barium, ganglion stimulation, 327 pulmonary reflexogenic activity, 404 Behavior, effect of chlorpromazine and imipramine Acheson, G. H., see Siegel, I. A., 298 on, 377 Acidic lipids, stimulant, released from intestine, effects of d-amphetamine and reserpine on, 167 215 5-hydroxytryptamine and self-stimulation, 147 Active transport, effect of ouabain in frog sar- Benzquinamide, antagonism of 5-hydroxytryp- torius muscle, 307 tamine, 400 Addiction to morphine, acute and chronic in spinal Berlin, M. and Rylander, R. , 236 dog, 385 Bevan, J. A., Murphy, T. M. and Hardy, P. M., 404 Addicts, potentiation of morphine by serum from Blood levels of drugs, calculation of kinetic con- human morphine addicts, 139 stants from, 271 Adrenal cortex, and circadian phase dependent Blood pressure, effect of hydroxyethyl starch as a toxicity of methopyrapone, 395 plasma expander, 359 Adrenergic drugs, effect on intestinal motility and Bloom, F. E., Costa, E. and Salmoiraghi, C. C., 16 release of stimulant lipids, 215 Boyd, E. S., see Stark, P., 147 Adrenergic receptors, effect of isopropylmethox- Bradykinin, antagonized by dicyclomine, 354 amine, 129 antidiuretic effect through ADH release, 24 -Adrenergic receptors, effect of pronethalol on Brain, uptake of mercury influenced by dimer- heart, 318 caprol, 236 Albuquerque, E. X. and Smith, C. M., 344 Bretylium, effect on segmental vascular reac- Alpers, H. S., see Shore, P. A., 194 tivity, 200 Altitude, influence on responses to electroshock Brom-lysergic acid diethylamide (BOL), and self- and to convulsant and anticonvulsant drugs, stimulation, 147 160 Busfield, D., see Shore, P. A., 194 p-Aminohippurate, influence of thyroxine and analogues on renal uptake, 294 Calcergy, production and inhibition by various Amphetamine, antagonism of reserpine-induced agents, 252 depression of conditioned behavior, 369 Calcium, chronotropic action on sinoatrial node, neuromuscular block as a component of toxicity, 111 175 effect on normal myometrium and uterine leio- d-Amphetamine, effects on operant behavior, 167 myoma, 313 Analgesia, comparison of drugs on tooth pulp Carbachol, pulmonary reflexogenic activity, 404 thresholds, 1 Carbonic anhydrase, effect of aromatic com- A.ndrogen hydroxylase, enhancement of activity pounds, 66 in liver microsomes by phenylbutazone, 225 Carboxypeptidase A, effect of aromatic com- Angiotensin, effect on blood vessels, 200 pounds, 66 Apticholinergic drugs, effect on egg deposition by Carboxypeptidase B, inhibition by aromatic com- a rotifer, 123 pounds, 66 Anticonvulsant drugs, influence of altitude on Carlini, G. R. S., Fischer, G. A. and Giarman, action, 160 N. J., 74 Antidiuretic hormone, release by bradykinin, 24 Carotid bodies, responses to drugs when tem- Anti-inflammatory substances, from pleural fluid, porally separated from aortic bodies, 33 258 Caruso, P. L., see Selye, H., 252 Aortic bodies, responses to drugs when temporally Castillo, L. S. and Timiras, P. S., 160 separated from carotid bodies, 33 Catalase, inhibition by aromatic compounds, 66 Aronson, A. L. and Hammond, P. B., 241 Catecholamine, disposition in develoning rat, 48 409 410 INDEX

labile stores in brain demonstrated by fluores- Dextran, compared with hydroxyethyl starch as cence microscope, 186 plasma expander, 359 Central nervous system, effect of drugs on chlor- Dicyclomine , antispasmodic actions compared promazine-induced depression, 180 with atropine, 354

localization of labile stores of monoamines, 186 2 - Diethoxyphosphenyl - thioethyldimethylamine role of 5-hydroxytryptamine on self-stimulation, acid oxalate (217 AO), effect on sympathetic 147 ganglia, 335 Chemoreceptors, responses of temporally sepa- fl-Diethylaminoethyl diphenyipropylacetate hy- rated aortic and carotid bodies to drugs, 33 drochloride, see SKF-525A, 265 Chen, K. K., see Kikuchi, K., 365 Digital computer programming of kinetics of drug Chlorpromazine, effect on pigeon behavior corn- distribution, 271 pared with imiprarnine, 377 Dimercaprol (BAL), effect on distribution of effect on tooth pulp threshold, 1 mercury, 236 -induced depression, effect of drugs, 180 Dimercaptopropanol (BAL), effect on distribution release of 5-HT from neoplastic mast cells, 74 and excretion of lead, 241 Choline phenyl ether , pulmonary reflexogenic 2,4-Dimethylphenacyl tetramethylammonium, activity, 404 pulmonary reflexogenic activity, 404 Cholinergic drugs, effect on egg deposition by a Diphenylhydantoin, influence of altitude on anti- rotifer, 123 convulsant action, 160 Cholinergic excitation of muscle spindle afferent Diuretics, comparison of natriuretic effects with nerves, 344 that of SKF-525A, 265 Chu, E. W., see Snyder, S. H., 276 DMPP, effect on myometrium, 313 Chymotrypsin, anti-inflammatory effect, 258 pulmonary reflexogenic activity, 404 Circadian rhythm, influence on effects of metho- Dopa decarboxylase inhibition, dissociation from pyrapone, 395 norepinephrine depletion, 42 Clift, J. W., see Kiplinger, G. F., 139 Drug absorption, use of goldfish, 80 Cocaine, effect on segmental vascular reactivity, 200 Eades, C. G., see Martin, W. R., 385 effects on operant behavior, 167 Electrophoretic application of drugs to rabbit Compound 48/80, effect on calcification of tissues, olfactory bulb, 16 252 Electroshock, influence of altitude on response, 160 Computer programming of kinetics of drug dis- seizure threshold, effect of hypertonic urea, 154 tribution, 271 Enzyme inhibition, by aromatic and nonaromatic Comroe, J. H., Jr. and Mortimer, L., 33 compounds, 66 Conditioned behavior, antagonistic effects of Epinephrine, effect on hindlimb vascular resist- amphetamine and reserpine on, 369 ance, 02 and Rb uptake, 117 Conney, A. H. and Schneidman, K., 225 effect on intestinal motility and release of stimu- see Kuntzman, R., 280 lant lipids, 215 Constantine, J. W. and Knott, C., 400 Ertel, R. J., Halberg, F. and Ungar, F., 395 Convulsant drugs, influence of altitude on action, Erulkar, S. D., see Csillik, B., 186 160 Ethylenediaminetetraacetic acid (EDTA), effect Corticosteroids, metabolism by liver microsomes on distribution and excretion of lead, 241 and effect of phenylbutazone, 225 Costa, E., see Bloom, F. E., 16 Fischer, G. A., see Carlini, G. R. S., 74 Csillik, B. and Erulkar, S. D., 186 Fosdick, L. S., see Sark.ar, N., 258 Cyanide, effects on temporally separated aortic Fouts, J. R., see Rogers, L. A., 286 and carotid bodies, 33 Fuller, R. W., see Stark, P., 147

Darmstoff, effect on intestinal motility and release Gabel, L. P., Winbury, M. M., Rowe, H. and of stimulant lipids, 215 Grandy, R. P., 117 Decarboxylase, see dopa decarboxylase, 42 Ganglia, effect of barium, 327 inhibitors, and self-stimulation, 147 modification of transmission by drugs, 335 Dehydrogenases, inhibition by aromatic com- Giarman, N. J., see Carlini, G. R. S., 74 pounds, 66 Gillis, C. N., 54 O-Demethylating system, kinetic properties, 61 Glowinski, J., Axelrod, J., Kopin, I. J. and Wurt- Depletion of norepinephrine by l-metaraminol, 194 man, R. J., 48 Development, influence on norepinephrine disposi- Glycogen in liver, effect of SKF 525A, 286 tion in rat, 48 Goldfish, for study of drug absorption, 80 INDEX 411

Goldman, H., see Lindner, L. A., 123 Kidney, action of ouabain on excretory anecha- Gourley, D. R. H., 307 nisms and Na-K ATP-ase, 92 Grandy, R. P., see Gabel, L. P., 117 effects of malachite green, 87 Gray, G. W., 215 natriuretic effect of SKF-525A, 265 Gucinski, S. P., see Levy, G., 80 Kikuchi, K. and Chen, K. K., 365 Kinetic analyses of drug absorption and disap- Halberg, F., see Ertel, R. J., 395 pearance, 271 Hammond, P. B., see Aronson, A. L., 241 Kiplinger, G. F. and Clift, J. W., 139 Hardinge, M. G., see Peterson, D. I., 175 Knott, C., see Constantine, J. W., 400 Hardy, P. M., see Bevan, J. A., 404 Koch-Weser, J., 318 Heart, direct negative chronotropic effect of 5- Kopin, I. J., see Glowinski, J., 48 hydroxytryptamine, 209 Kuhn, W. L., see McGrath, W. R., 354 effect of pronethalol, 318 Kuntzman, R., Jacobson, M., Schneidman, K. and effect of rhodexin A, 365 Conney, A. H., 280 effects of pentobarbital and calcium on rate, 111 microsomes and retention of norepinephrine, 54 Langer, S. Z. and Trendelenburg, U., 99 rate, influence of veratramine, norepinephrine Lavender, A. R. and Pullman, T. N., 87 and histamine, 99 Lead, effect of chelating agents on distribution Hexamethonium, antagonism of barium-induced and excretion, 241 ganglion stimulation, 327 Leiomyomata, effects of drugs on contractile Histamine, antagonized by dicyclomine, 354 activity, 313 effect on calcification of tissues, 252 Levine, R. J. and Sjoerdsma, A., 42 interaction with veratramine on atrial rate, 99 Levy, B., 129 reversal of chlorpromazine-induced depression, Levy, G. and Gucinski, S. P., 80 180 Lewis, R. E., see McGrath, W. R., 354 Histochemical localization of monoamines in Lindner, L. A. and Goldman, H., 123 central nervous system, 186 Lipids, stimulant, released from intestine, 215 Hook, J. B. and Williamson, H. E., 265 Little, J. M., see Nepomuceno, C. G., 294 Hydroxyethyl starch, effects on circulation corn- Liver microsomal metabolism of drugs and ster- pared with blood replacement fluids, 359 oids, 280 5-Hydroxytryptamine (5-HT), antagonism by Lobeline, pulmonary reflexogenic activity, 404 benzquinamide, 400 Local anesthetic drugs, effect on intestinal motil- effect on calcification of tissues, 252 ity and release of stimulant lipids, 215 electrophoretic application to olfactory bulb, 16 negative chronotropic effect on sinoatrial node, McGrath, W. R., Lewis, R. E. and Kuhn, W. L., 209 354 possible role in self-stimulation, 147 Malachite green, renal actions, 87 release from neoplastic mast cells induced by Malnic, G., see Rocha e Silva, M., Jr., 24 reserpine and chlorpromazine, 74 Martin, W. R. and Eades, C. G., 385 uptake by uterus, heart and spleen, 276 Mast cells, neoplastic, effect of reserpine and chlorpromazine on 5-HT content, 74 Imipramine, effect on pigeon behavior compared Mastocalcergy, see calcergy, 252 with chlorpromazine, 377 Mathematical analysis of drug distribution, 271 effects on operant behavior, 167 Mecamylamine, antagonism of barium-induced Inflammation, antagonistic effect of chymotryp- ganglion stimulation, 327 sin, 258 Membranes, use of goldfish for permeation kinet- Intestinal motility, effect of stimulant lipids, 215 ics, 80 Iproniazid, effect on microsomal drug metabolism, Mercury, uptake by brain, 236 286 Metanicotine, pulmonary reflexogenic activity, N -Isopropylmethoxamine, effect on adrenergic 404 responses, 129 l-Metaraminol, binding and depletion of norepi- effect on intestinal motility and release of stimu- nephrine, 194 lant lipids, 215 Methacholine (Mecholyl), effect on sympathetic Isoproterenol, effect on myometrium, 313 ganglia, 335 pulmonary reflexogenic activity, 404 Jacobson, M., see Kuntzman, R., 280 Methopyrapone (SU-4885), effects dependent on James, T. N., 209 circadian rhythm, 395 412 INDEX

Methoxamine, influence on adrenergic responses, effect on hindlimb vascular resistance, 02 up- 129 take and Rb86 uptake, 117 3-Methylcholanthrene, effect on liver metabolism effect on myometrium, 313 of corticosteroids, 225 electrophoretic application to olfactory bulb, 16 a-Methyl dopa and related substances on decar- interaction with veratramine on atrial rate, 99 boxylase and norepinephrine depletion, 42 physiological disposition in developing rat, 48 a-Methyl-m-tyramine, mechanism of norepineph- retention by heart subcellular fraction, 54 rine depletion, 194 a-Methyl-m-tyrosine , mechanism of norepineph- Olfactory bulb, neuron responses to electro- rine depletion, 194 phoretically applied drugs, 16 Microsomal drug metabolism, effect of SKF 525A Ouabain, effect on potassium flux in skeletal and iproniazid, 286 muscle, 307 Microsomes, comparison of original and induced effect on renal excretory mechanisms and 0-demethylases, 61 Na-K ATP-ase, 92 heart, retention of norepinephrine, 54 Oxidation of drugs and steroids by liver micro- in liver, metabolism of drugs and steroids, 280 somes, 280 Mitchell, C. L., 1 see Straw, R. N., 7 Monoamine oxidase inhibitors, and self-stimula- Palmer, R. F. and Nechay, B. R., 92 tion, 147 Pentazocine, effect on brain stem tooth pulp- Monoamines, labile stores in brain, 186 evoked potentials, 7 Morphine, acute and chronic addiction in spinal Pentobarbital, effect on brain stem tooth pulp- dog, 385 evoked potentials, 7 effect on brain stem tooth pulp-evoked poten- effect on tooth pulp threshold, 1 tials, 7 rate decreasing effect on sinoatrial node, 111 effect on tooth pulp threshold, 1 Pentylenetetrazol, influence of altitude on action, potentiation of effect by serum from morphine- 160 tolerant animals, 139 Peroxidase, effect of aromatic compounds, 66 Mortimer, L., see Comroe, J. H., Jr., 33 Peterson, D. I., Hardinge, M. G. and Tilton, B. E., Murphy, T. M., see Bevan, J. A., 404 175 Muscle, skeletal, effect of ouabain on potassium Phenylbutazone, enhancement of steroid hy- flux, 307 droxylase activity, 225 spindle afferent, nerve excitation by cholinergic Phenyldiguanide, effects on temporally separated substances, 344 aortic and carotid bodies, 33 Myometrium, see uterus, 313 Philodina acuticornis, egg deposition influenced by drugs, 123 Nalorphine, effect in acute and chronic addiction Physostigmine, effect on sympathetic ganglia, 335 in spinal dog, 385 Pilocarpine, effect on sympathetic ganglia, 335 effect on brain stem tooth pulp-evoked poten- Pipradrol, effects on operant behavior, 167 tials, 7 Plasma substitutes, hydroxyethyl starch corn-#{149} Natriuresis, effect of SKF-525A and other drugs, pared with others, 359 265 Polymyxin, effect on calcification of tissues, 252 Nechay, B. R., see Palmer, R. F., 92 Potassium, effect on normal myometrium and Nepomuceno, C. G. and Little, J. M., 294 uterine leiomyoma, 313 Nethalide, see pronethalol, 318 fluxes in muscle, effect of ouabain, 307 Netter, K. J. and Seidel, G., 61 salivary, effect of acetyl strophanthidin on, 298 Neuromuscular blocking action of amphetamine, Potentiation, of morphine effect by serum from 175 morphine-tolerant animals, 139 Nicotine, effects on temporally separated aortic Pronethalol, direct and adrenergic blocking ac- and carotid bodies, 33 tions on heart, 318 pulmonary reflexogenic activity, 404 Pullman, T. N., see Lavender, A. R., 87 p-Nitroanisole, microsomal demethylation, 61 Pulmonary artery reflexogenic area, effect of p-Nitrophenol, microsomal demethylation, 61 nicotinic and muscarinic drugs, 404 Norepinephrine, depletion and l-metaraminol binding, 194 depletion, dissociation from dopa decarboxylase Receptors, effect of pronethalol on heart, 318 inhibition, 42 Rech, R. H., 369 effect on blood vessels, 200 Reed, D. J. and Woodbury, D. M., 154 INDEX 413

Reserpine, and retention of norepinephrine by Snyder, S. H., Wurtman, R. J., Axelrod, J. and heart microsornes in vitro, 54 Chu, E. W., 276 depression of conditioned behavior antagonized Spinal cord, role in morphine addiction, 385 by reserpine, 369 Stark, P., Boyd, E. S. and Fuller, R. W., 147 effect on intestinal motility and release of stimu- Stein, A. A., see Rosenblum, I., 313 lant lipids, 215 Steroid hydroxylases, enhancement of activity in enhancement of d-amphetamine effect on oper- liver microsomes by phenylbutazone, 225 ant behavior, 167 similarity to drug metabolizing enzymes in liver release of 5-HT from neoplastic mast cells, 74 microsornes, 280 reversal of chlorprornazine-induced depression, Stimulant lipids, 215 180 Straw, R. N. and Mitchell, C. L., 7 Rhodexin A, cardiovascular actions of, 365 Strychnine, influence of altitude on action, 160 Rocha e Silva, M., Jr. and Malnic, G., 24 Succinylcholine excitation of muscle spindle Rogers, L. A. and Fouts, J. R., 286 afferent nerves, 344 Rosenberg, F. J. and Savarie, P. J., 180 Rosenblum, I. and Stein, A. A., 313 Takeshige, C. and Volle, R. L., 327, 33.5 Rotifers, influence of cholinergic drugs on egg Tetraethylammonium, effect on segmental vascu - deposition, 123 lar reactivity, 200 Rowe, H., see Gabel, L. P., 117 influence of thyroxine and analogues on renal Rubidium-86, effect of drugs on uptake in dog uptake, 294 hindlimb, 117 Tetramethylammonium, effect on sympathetic Rylander, R., see Berlin, M., 236 ganglia, 335 Thompson, W. L. and Walton, R. P., 359 Salivary glands, effect of acetyl strophanthidin Thyroxine and analogues, effect on renal uptake on potassium, 298 of para-aminohippurate and tetraethylam- Salmoiraghi, G. C., see Bloom, F. E., 16 monium, 294 Sanders, P. G., see Wiegand, R. G., 271 Tilton, B. E., see Peterson, D. I., 175 Sarkar, N. and Fosdick, L. S., 258 Timiras, P. S., see Castillo, L. S., 160 Savarie, P. J., see Rosenberg, F. J., 180 Tolerance to morphine, production of morphine Schaer, H., 111 potentiating serum, 139 Schneidman, K., see Conney, A. H., 225 p-Tolylether of choline (TEC), and retention of see Kuntzman, R., 280 norepinephrine by heart microsomes in vitro, Schulman, M. P., see Vogel, W. H., 66 54 Seidel, G., see Netter, K. J., 61 Tooth pulp evoked potentials, effects of drugs on, 7 Self-stimulation, effect of 5-hydroxytryptamine, Tooth pulp thresholds, as analgesic test, 1 147 Toxicity of amphetamine, neuromuscular blocking Selye, H., Tuchweber, B. and Caruso, P. L., 252 action as a component, 175 Serotonin, effects on temporally separated aortic Trachea, effect of benzquinamide and 5-hydroxy- and carotid bodies, 33 tryptamine, 400 see 5-hydroxytryptamine, 74, 147, 209 Trendelenburg, U., see Langer, S. Z., 99 uptake by uterus, heart and spleen, 276 Tuchweber, B., see Selye, H., 252 Tyramine, effect on retention of norepinephrine by Serum, rnorphine-potentiating properties, 139 heart microsomes in vitro, 54 Shore, P. A., Busfield, D. and Alpers, H. S., 194 Siegel, I. A. and Acheson, G. H., 298 Sinoatrial node, effects of pentobarbital and cal- LJngar, F., see Ertel, R. J., 395 cium on rate, 111 Urea, hypertonic, on brain excitability and elec- of heart, effect of 5-hydroxytryptamine on, 209 trolyte distribution, 154 Sjoerdsma, A., see Levine, R. J., 42 Uterus, effects of drugs on contractile activity, 313 SKF 525A, effect on microsomal drug metabolism, uptake and release of serotonin (5-hydroxy- 286 tryptamine), 276 natriuretic effect in dogs, 265 Smith, C. B., 167 Vaillant, G. E., 377 Smith, C. M., see Albuquerque, E. X., 344 Vascular reactivity, segmental, effect of drugs, 200 Smooth muscle, effect of dicyclomine on guinea- Vasopressin, effect on hindlimb, 117 pig ileum, 354 Veratramine, action of atrial pacemaker, 99 Snyder, R., see Vogel, W. H., 66 Veratridine, effect on sympathetic ganglia, 327 414 INDEX

Vogel, W. H., Snyder, R. and Schulman, M. P., 66 Winbury, i\1. M., see Gabel, L. P., 117 Volle, R. L., see Takeshige, C., 327, 335 Woodbury, D. M., see Reed, D. J., 154 Wurtman, R. J., see Glowinski, J., 48 Walton, R. P., see Thompson, W. L., 359 see Snyder, S. H., 276 Wiegand, R. G. and Sanders, P. G., 271 Williamson, H. E., see Hook, J. B., 265 Zimmerman, B. G., 200

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