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Multi-Drug Saliva Test Tube Number: PI4009504 Version: CE1.0 12/18/2018

WP4029U WP4039U WP4049U WP4059U Methylenedioxypyrovalerone Methylenedioxypyrovalerone 500 is a potent chemically related to WP4069U WP4079U WP4089U WP4099U (MDPV) but with greater CNS stimulation properties. The drug WP4109U WP4119U WP4129U is often self-administered by nasal inhalation, smoking or oral This assay provides only a qualitative, preliminary analytical test ingestion. result. A more specific alternate chemical method must be used in The Multi-Drug Saliva Test Tube is intended for simultaneous order to obtain a confirmed analytical result. Gas MTD testing any combination from 2 to 12 (WP4029U-WP4129U) of the chromatography/mass spectrometry (GC/MS) is the preferred Methadone is a narcotic analgesic prescribed for the management of following drugs: confirmatory method. Clinical consideration and professional moderate to severe pain and for the treatment of opiate dependence Amphetamine (AMP), Barbiturates (BAR), Benzodiazepines (BZO), judgment should be applied to any drug of abuse test result, (Heroin, Vicodin, Percocet, morphine).The pharmacology of oral Buprenorphine (BUP), (COC), Methadone (MTD), particularly when preliminary results are positive. methadone is very different from IV methadone. Oral methadone is Methamphetamine (MET), Methylenedioxymethamphetamine partially stored in the liver for later use. IV methadone acts more SUMMARY (MDMA), Morphine (MOP), Oxycodone (OXY), like heroin. AMP (PCP), Marijuana (THC), Tricyclic (TCA), Methadone is a long acting pain reliever producing effects that last Methadone metabolite (EDDP), Cotinine (COT), (KET), Amphetamine is a sympathomimetic amine with therapeutic from twelve to forty-eight hours. Ideally, methadone frees the client Methylenedioxypyrovalerone (MDPV). indications. The drug is often self-administered by nasal inhalation from the pressures of obtaining illegal heroin, from the dangers of The test combinations of Multi-Drug Saliva Test Tube are not or oral ingestion. injection, and from the emotional roller coaster that most opiates constant. Please identify the test combinations through the BAR produce. Methadone, if taken for long periods and at large doses, packaging labels of the products. can lead to a very long withdrawal period. Barbiturates are central nervous system (CNS) depressants. They For in vitro diagnostic use only. For healthcare professional use are used therapeutically as sedatives, hypnotics, and anticonvulsants. MDMA only. Barbiturates are almost always taken orally as capsules or tablets. MDMA is an abbreviation for the chemical The effects resemble those of intoxication with alcohol. Chronic INTENDED USE methylenedioxymethamphetamine MDMA. It has street many name use of barbiturates leads to tolerance and physical dependence. including Ecstasy, X, XTC, E, Love Doves, Clarity, Adam, Disco The Multi-Drug Saliva Test Tube is a lateral flow chromatographic BZO Biscuits and Shamrocks, etc. It is a stimulant with hallucinogenic immunoassay for the detection of drugs and drug metabolites in tendencies, described as an empathogen as it releases mood-altering Benzodiazepines are medications that are frequently prescribed for human saliva at the following cut-off concentrations: chemicals, such as cartooning and L-dopa, in the brain and may the symptomatic treatment of anxiety and sleep disorders. generate feelings of love and friendliness. MDMA is a Class A drug, Cut-off Test Calibrator in the same category as heroin and cocaine. The adverse effects of (ng/ml) BUP MOMA use include elevated , hyperthermia, anxiety, Amphetamine (AMP) d-Amphetamine 50 Buprenorphine is a potent analgesic often used in the treatment of paranoia, and insomnia. Overdoses of MDMA can be fatal, often Barbiturates (BAR) Secobarbital 60 opioid addiction. Therapeutically, Buprenorphine is used as a resulting in heart failure or heart stoke. MDMA belongs to a family Benzodiazepines (BZO) Oxazepam 10 substitution treatment for opioid addicts. Substitution treatment is a of man-made drugs; its relatives include MDA (methylenedioxy form of medical care offered to opiate addicts (primarily heroin Buprenorphine (BUP) Buprenorphine 5 MDMA), the parent drug of MDMA, and MDEA addicts) based on a similar or identical substance to the drug Cocaine (COC) Benzoylecgonine 20 (methylenedioxyethyl MDMA), also known as EVE. They all share normally used. In substitution therapy, Buprenorphine is as Methadone (MTD) Methadone 30 the MOMA-like effects. MDMA is administered either by oral effective as Methadone but demonstrates a lower level of physical Methamphetamine (MET) d-Methamphetamine 50 ingestion or intravenous injection. MDMA tablets come in different dependence. Methylenedioxymethamphetamine 3,4-Methylenedioxymethamphetamin 50 sizes and colors, and often have logos such as doves on them. Its (MDMA) e HCl Substantial abuse of Buprenorphine has also been reported in many clinical dose is 50-100 mg; the threshold toxic dose is 500mg. The Morphine (MOP) Morphine 40 countries where various forms of the drug are available. The drug effects of MDMA begin 30 minutes after intake. They peak in an Oxycodone (OXY) Oxycodone 20 has been diverted from legitimate channels through theft, doctor hour and last for 2-3 hours. it is detectible in the saliva for up to 3 Phencyclidine (PCP ) Phencyclidine 10 shopping, and fraudulent prescriptions, and been abused via days after use. intravenous, sublingual, intranasal and inhalation routes. Marijuana (THC) 11-nor-Δ9-THC-9 COOH 12 MOP Tricyclic Antidepressants (TCA ) 100 COC Methadone metabolite (EDDP) 2-Ethylidene-1,5-dimethyl-3, 20 The opiates such as heroin, morphine, and codeine are derived from Cocaine is a potent CNS stimulant and a local anesthetic derived 3-diphenylpyrrolidine (EDDP) the resin of opium poppy. The principal metabolites of opiates are from the plant (erythroxylum coca). morphine, morphine-3-glucuroride, normorphine and codeine with Cotinine (COT) Cotinine 50 a half-life of about 3 hours. Heroin is quickly metabolized to Ketamine (KET) Ketamine 100 MET morphine. Thus, morphine and morphine glucuronide might both be 1 / 6 found in the saliva of a person who has taken only heroin. The body Cotinine is the first-stage metabolite of nicotine, a toxic alkaloid also changes codeine to morphine. Thus, the presence of morphine that stimulates the autonomic ganglia and central nervous system in PRINCIPLE (or the metabolite, morphine glucuronide) in the saliva indicates humans. Nicotine is a drug to which virtually every member of a heroin, morphine and/or codeine use. tobacco-smoking society is exposed whether through direct contact The Multi-Drug Saliva Test Tube is a competitive immunoassay The window of detection varies for different opiates. Codeine can or second-hand inhalation. Aside from tobacco, nicotine is also that is used to screen for the presence of drugs of abuse in oral fluid. be detected within one hour and up to 7-21 hours after a single oral commercially available as the active ingredient in smoking It is chromatographic absorbent device in which drugs or drug dose. Morphine is detectable for several days after a dose. replacement therapies such as nicotine gum, transdermal patches metabolites in a sample competitively combined to a limited and nasal sprays. Regardless of whether nicotine in a donor was number of antibody-dye conjugate binding sites. OXY derived from tobacco use or through a nicotine-replacement therapy, Oxycodone is a semi-synthetic opioid with a structural similarity to if the metabolite cotinine is present in sufficient concentration, the When the sample is added to the sample well, the sample is codeine. The drug is manufactured by modifying thebaine, an test result will be positive. absorbed into the device by capillary action, mixes with the alkaloid found in the opium poppy. Oxycodone, like all opiate antibody-dye conjugate, and flows across the pre-coated membrane. Although nicotine is excreted in saliva, the relatively short half-life When sample drug levels are zero or below the target cutoff (the , provides pain relief by acting on opioid receptors in the of the drug makes it an unreliable marker for tobacco use. Cotinine, spinal cord, brain, and possibly directly in the affected tissues. detection sensitivity of the test), antibody-dye conjugate binds to however, demonstrates a substantially longer half-life than nicotine, the drug /protein conjugate immobilized in the Test Region (T) of PCP bears a high correlation with plasma cotinine levels and has been the device. This produces a colored Test line that, regardless of its found to be the best marker for smoking status compared with Phencyclidine the commonly referred to as Angel intensity, indicates a negative result. saliva nicotine measurements, breath testing and Dust, can be detected in oral fluid as a result of the exchange of the plasma thiocyanate testing1. When sample drug levels are at or above the target cutoff, the free drug between the circulatory system and the oral cavity. drug in the sample binds to the antibody-dye conjugate preventing KET THC the antibody-dye conjugate from binding to the drug-protein Ketamine is a dissociative anesthetic developed in 1963 to replace conjugate immobilized in the Test Region (T) of the device. This Tetrahydrocannabinol, the active ingredient in the marijuana plant PCP (Phencyclidine). While Ketamine is still used in human prevents the development of a distinct colored band in the test (cannabis sativa), is detectable in oral fluid shortly after use. The anesthesia and veterinary medicine, ii is becoming increasingly region, indicating a potentially positive result. detection of the drug is thought to be primarily due to the direct abused as a street drug. exposure of the drug to the mouth (oral and smoking To serve as a procedure control, a colored line will appear at the administrations) and the subsequent sequestering of the drug in the Ketamine is molecularly similar to PCP and thus creates similar Control Region (C), if the test has been performed properly. buccal cavity. effects including numbness, loss of coordination, sense of invulnerability, muscle rigidity, aggressive I violent behavior, TCA PRECAUTIONS slurred or blocked speech, exaggerated sense of strength, and a Tricyclic Antidepressants (TCA) are commonly used for the blank stare. There is depression of respiratory function but not of 1. This kit is for in vitro use only. Do not swallow. treatment of depressive disorders. TCA overdoses can result in the central nervous system, and cardiovascular function is profound central nervous system depression, cardiotoxicity and maintained. 2. Discard after first use. The test cannot be used more than anticholinergic effects. TCA overdose is the most common cause of once. MDPV death from prescription drugs. TCAs are taken orally or sometimes 3. Do not use test kit beyond expiration date. by injection. TCAs are metabolized in the liver. "", a fonm of designer drugs, also promoted as 'plant food' or 'research chemicals' and is sold mainly in head shops, on the 4. Do not use the kit if the pouch is punctured or not well EDDP Internet, and at other retail locations. Designer drugs were sealed. Methadone (MTD) is a synthetic analgesic drug that is originally developed in recent years to subvert law enforcement and drug 5. Keep out of the reach of children. used in the treatment of narcotic addicts. Among the psychological testing agencies and are advertised a 'legal' high. The technical term 6. Do not read after 5 minutes. effects induced by using methadone are analgesia, sedation and for 'bath salts' is substituted . is respiratory depression. Overdose of methadone may cause coma or synthetic, concentrated version of the stimulant chemical in . 7. The used collector and device should be discarded according even death. It is administered orally or intravenously and is Khat is a plant that is cultivated and used in East Africa and the to local regulations. metabolized in the liver. The kidneys are a major route of Middle East. It has a stimulant effect on the user and can be quite 8. Keep test device in the sealed pouch until use. methadone . Methadone has a biological half-life of 16-50 dangerous. The white crystals resemble legal bathing salts, thus the hours. EDDP (2-Ethyliden-1,5-Dimethyl- 3,3-Diphenylpyrrolidine) name of 'bath salts'. is the most important metabolite of methadone. It is formed by MATERIAL Established as one of the main ingredients for 'bath salts' among N-demethylation and cyclization of methadone in the liver. The other synthetic like , , detection of the metabolite EDDP instead of methadone itself is Material Provided and , MDPV started appearing around 2004 when it useful, because interferences of the patient's metabolism are was popularized as a club drug, often used in combination with avoided. 1. 25 individual sealed pouches, each containing: alcohol, GHB, cannabis and other drugs of abuse, for its desired COT effects such as euphoria, alertness, talkativeness, and sexual arousal. • Test tube • Desiccant There are currently no prescribed uses for the synthetic stimulants. 2. Package insert 2 / 6

GC/MS confirmation if necessary. Material Required But Not Provided QUALITY CONTROL

• Timer Though there is an internal procedural control line in the test device of Control region, the use of external controls is strongly STORAGE AND STABILITY recommended as good laboratory testing practice to confirm the test procedure and to verify proper test performance. Positive and 1. Store at 4 ºC ~30 ºC in the sealed pouch up to the expiration negative control should give the expected results. When testing the date. positive and negative control, the same assay procedure should be adopted. 2. Keep away from direct sunlight, moisture and heat. 3. DO NOT FREEZE. LIMITATIONS OF PROCEDURE

4. Preferably open the pouch only shortly before the test. 1. The test provides only a qualitative, preliminary analytical result. A secondary analytical method must be used to obtain SPECIMEN COLLECTION AND PREPARATION a confirmed result. Gas chromatography/mass spectrometry (GC/MS) is preferred confirmatory methods. The oral fluid specimen should be collected using the collector 2. A positive test result does not indicate the concentration of provided with the kit. Follow the detailed Directions for Use below. drug in the specimen or the route of administration. No other collection devices should be used with this assay. Oral fluid collected at any time of the day may be used. 3. A negative result may not necessarily indicate a drug-free specimen. Drug may be present in the specimen below the TEST PROCEDURE cutoff level of the assay. 4. Do not use samples suspected of deterioration or Allow the test device to reach room temperature [10℃-30°C] prior contamination. Contaminants may interfere with the test and to testing. Do not place anything in the mouth including food, drink, INTERPRETATION OF RESULTS cause false results. gum, or tobacco products for at least 10 minutes prior to collection of oral fluid specimen. Positive (+) 1. Bring the pouch to room temperature before opening it. One colored line appears in the control line region (C). No line EXPECTED VALUES Remove the test from the sealed pouch and use it as soon as appears in the test line region (T). This positive result indicates that possible. the drug concentration exceeds the detectable level. Creatinine: The daily creatinine excretion is usually constant, and 2. Insert the sponge end of the collection stick into the mouth. it is consistent with the muscle mass of the human body3. The DOT Close mouth and gently soak sponge into mouth and swab the Negative (-) provides a guideline that when the urine sample has a creatinine inside of the mouth(cheek) and/or under the tongue to collect Two lines appear. One colored line should be in the control line level of less than 20mg/dL, it is likely diluted2. Even though oral fluid until the sponge becomes completely soft and fully region (C), and another apparent colored line should be in the test creatinine levels differs by age, sex, diet, muscle mass, and local saturated with saliva that the stick of collector will turns into line region (T). This negative result indicates that the drug population distribution4, urine samples with creatinine levels of red. No hard spots should be felt on the sponge when concentration is below the detectable level. lower than 20mg/dL does not occur in natural urine and should be saturated. Do not chew the sponge. (Step1) considered diluted. NOTE: After the sponge inserting into the mouth for over 7 Invalid minutes, the stick of collector does not turn into red. Please Control line fails to appear. Insufficient specimen volume or Nitrite: Even though nitrite is not a normal component of urine; proceed to next step. incorrect procedural techniques are the most likely reasons for urinary tract infections, bacterial contaminations, or improper 3. Remove the sponge from the mouth. With gentle pressure, control line failure. Review the procedure and repeat the test using storage can all cause nitrite levels to be as high as 3.6mg/dL. place the collection stick with saturated sponge into a new test. If the problem persists, discontinue using the lot Nonetheless, nitrite levels above 50 mg/dL are abnormal and are Collection Chamber. (Step 2) immediately and contact your local distributor with the lot number. considered adulterated by the DOT guidelines2. 4. Screw the Collector Cap clockwise to secure the cap and start Glutaraldehyde: Glutaraldehyde is not present in normal urine, the timer. (Step 3) Note: There is no meaning attributed to line color intensity or and many commercially sold adulterants contain glutaraldehyde. 5. Peel off the label to read test results. Wait for the color line(s) width. Therefore, detection of glutaraldehyde in the urine sample should to appear on the test strips. Read results in 5 minutes. Do indicate adulteration. False positive results can results from not read results after 5 minutes. (Step 4) ketoacidosis, starvation, or other metabolic abnormalities, as the bodies generated can react with the glutaraldehyde indicator Send the collector with collected oral fluid to the laboratory for to produce a positive coloration.

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Bleach: The presence of bleach in the urine sample is a sign of Pos. (+) 0 0 0 15 16 +50%Cut-off 30 0 30 0 30 0 30 0 30 MOP 97.9% 100% adulteration. Other oxidative adulterants such as hydrogen peroxide, Neg. (-) 16 16 16 1 0 Pos. (+) 0 0 0 15 16 Drug Conc. MDPV Ferricyanide, Persulfate, Pyridinium Chlorochromate etc can also OXY 97.9% 100% n Neg. (-) 16 16 16 1 0 (Cut-off Range) - + be detected by this test. Pos. (+) 0 0 1 16 16 PCP 100% 97.9% 0%Cut-off 30 30 0 pH: Normal Urine pH is usually from 4.5 to 8.0. Thus, a pH below Neg. (-) 16 16 15 0 0 -50%Cut-off 30 30 0 Pos. (+) 0 0 1 15 16 3.0 or above 11.0 is a sign of adulteration. THC 97.9% 97.9% -25%Cut-off 30 27 3 Neg. (-) 16 16 15 1 0 Cut-off 30 18 12 Specific Gravity: Adults with a normal diet or fluid intake would Pos. (+) 0 0 0 16 16 TCA 100% 100% +25%Cut-off 30 0 30 have urine with a specific gravity between 1.016 and 1.022. Neg. (-) 16 16 16 0 0 +50%Cut-off 30 0 30 Pos. (+) 0 0 2 16 16 Nonetheless, results between 1.001 and 1.035 are still considered EDDP 100% 95.8% Neg. (-) 16 16 14 0 0 Analytical Specificity normal3. The specific gravity of the urine might be elevated by Pos. (+) 0 0 0 16 16 COT 100% 100% high protein concentrations. According to the DOT guidelines2, a Neg. (-) 16 16 16 0 0 urine sample with a specific gravity of less than 1.003 should Pos. (+) 0 0 1 16 16 The following table lists the concentration of compounds (ng/mL) KET 100% 97.9% indicate adulteration. Moreover, results from both the specific Neg. (-) 16 16 15 0 0 above which the Multi-Drug Saliva Test Tube identified positive Pos. (+) 0 0 0 15 16 results at a read time of 5 minutes. gravity test and the creatinine test should be considered as a whole MDPV 97.9% 100% Neg. (-) 16 16 16 1 0 to decide if the sample has been adulterated. Compound ng/mL Amphetamine (AMP) Pyridinium Chlorochromate/ Oxidants: The presence of Analytical Sensitivity d-Amphetamine 50 Pyridinium Chlorochromate in the urine sample is a sign of d,1-Amphetamine 125 adulteration. Other oxidative adulterants such as hydrogen peroxide, Standard drugs were spiked into negative PBS pool to the 13-Phenylethylamine 4,000 Ferricyanide, Persulfate, Pyridinium Chlorochromate etc can also concentration of -50% cutoff, -25% cutoff, cutoff, +25% cutoff and 1,500 be detected by this test. +50% cutoff. The results were summarized below. p-Hydroxyamphetamine 800 (+) 3,4-Methylenedioxyamphelamine (MDA) 150 Drug Conc. AMP BAR BZO BUP n l-Amphetamine 4,000 PERFORMANCE CHARACTERISTICS (Cut-off Range) - + - + - + - + Barbiturates (BAR) 0%Cut-off 30 30 0 30 0 30 0 30 0 Secobarbital 60 -50%Cut-off 30 30 0 30 0 30 0 30 0 Accuracy Amobarbital 60 -25%Cut-off 30 28 2 29 1 26 4 27 3 Alphenol 30 1360 (eighty of each drug)clinical saliva specimens were analyzed Cut-off 30 12 18 12 18 10 20 16 14 Aprobarbital 40 by GC-MS and by each corresponding drug of abuse Test. Samples +25%Cut-off 30 0 30 0 30 0 30 0 30 Butabarbital 15 +50%Cut-off 30 0 30 0 30 0 30 0 30 were divided by concentration into five categories: A (drug-free), B Butathal 20 Butalbital 500 (less than half the cutoff), C (near cutoff negative, between 50% Drug Conc. COC MTD MET MDMA Cyclopentobarbital 120 n below the cutoff and the cutoff concentration), D (near cutoff (Cut-off Range) - + - + - + - + Pentobarbital 60 positive, between the cutoff and 50% above the cutoff 0%Cut-off 30 30 0 30 0 30 0 30 0 Phenobarbital 2000 concentration), and E (high positive, greater than 50% above the -50%Cut-off 30 30 0 30 0 30 0 30 0 Benzodiazepines (BZO) cutoff concentration). Results were as follows: -25%Cut-off 30 26 4 29 1 28 2 25 5 Oxazepam 10 Cut-off 30 14 16 10 20 10 20 14 16 Alprazolam 6 +25%Cut-off 30 0 30 0 30 0 30 0 30 Bromazepam 12 %Agreement with +50%Cut-off 30 0 30 0 30 0 30 0 30 Chlordiazepoxide 12 Drug test Result A B C D E GC/MS Clobazam 6 Pos. (+) Neg. (-) Clorazepate 25 Pos. (+) 0 0 1 16 16 Drug Conc. MOP OXY PCP THC AMP 100% 97.9% n Delorazepam 25 Neg. (-) 16 16 15 0 0 (Cut-off Range) - + - + - + - + Desalkylflurazepam 25 Pos. (+) 0 0 2 16 16 0%Cut-off 30 30 0 30 0 30 0 30 0 BAR 100% 95.8% Diazepam 3 Neg. (-) 16 16 14 0 0 -50%Cut-off 30 30 0 30 0 30 0 30 0 Estazolam 3 Pos. (+) 0 0 1 15 16 -25%Cut-off 30 26 4 28 2 30 0 14 16 BZO 97.9% 97.9% Flunitrazepam 100 Neg. (-) 16 16 15 1 0 Cut-off 30 12 18 12 18 20 10 14 16 a-Hydroxyalprazolam 200 Pos. (+) 0 0 2 15 16 +25%Cut-off 30 0 30 0 30 0 30 0 30 BUP 97.9% 95.8% (±)-Lorazepam 200 Neg. (-) 16 16 14 1 0 +50%Cut-off 30 0 30 0 30 0 30 0 30 Midazolam 25 Pos. (+) 0 0 0 14 16 COC 95.8% 100% Nitrazepam 12 Neg. (-) 16 16 16 2 0 Drug Conc. TCA EDDP COT KET n Norchlordiazepoxide 200 Pos. (+) 0 0 2 16 16 (Cut-off Range) - + - + - + - + MTD 100% 95.8% Nordiazepam 25 Neg. (-) 16 16 14 0 0 0%Cut-off 30 30 0 30 0 30 0 30 0 Temazepam 6 Pos. (+) 0 0 1 16 16 -50%Cut-off 30 30 0 30 0 30 0 30 0 MET 100% 97.9% Triazolam 25 Neg. (-) 16 16 15 0 0 -25%Cut-off 30 25 5 27 3 29 1 27 3 Butethal 30 Pos. (+) 0 0 2 16 16 Cut-off 30 20 10 14 16 12 18 14 16 MDMA 100% 95.8% Cyclopentobarbital 60 Neg. (-) 16 16 14 0 0 +25%Cut-off 30 0 30 0 30 0 30 0 30 Pentobarbital 150 4 / 6

Phenobarbital 30 Cannabinol 31,500 Meprobamate Buprenorphine (BUP) 11-nor-Δ8-THC-9 COOH 2 Ampicillin （except MDPV test） Buprenorphine 5 Δ8-THC 6,000 Amitryptyline Nalidixic acid Buprenorphine-3-D-Glucuronide 10 Δ9-THC 20,000 Ascorbic acid Naproxen Norbuprenorphine 5 Tricyclic Antidepressants (TCA) Niacinamide Buprenorphine-3-D-Glucuronide 10 Nortriptyline 100 Aspartame Nifedipine Buprenorphine Glucuronide 20 250 Atropine Nimesulide Cocaine (COC) 5,000 Benzilic acid Norethindrone Benzoylecgonine 20 20 Benzoic acid Noscapine Cocaine 20 Doxepine 30 d,1- Cocaethylene 25 2,000 Oxalic acid Ecgonine 1,500 10,000 Chloral hydrate Oxolinic acid Ecgoninemethylester 12,500 1,500 Chloramphenicol N-Acetylprocainamide 12,500 6,000 Chlorothiazide Papaverine Chlordiazepoxide 12,500 500 d,1-Chloropheniramine Penicillin-G Methadone (MTD) 5,000 5-Hydroxytryptamine Methadone 30 Hydrochloride 500 Pentazocine Doxylamine 50,000 5,000 Chloroquine Estrone-3-Sulfate 50,000 Methadone metabolite (EDDP) Cholesterol Phencyclidine 50,000 EDDP 20 Trans-2-phenylcyclo- Triamterene Methamphetamine (MET) Meperidine 20,000 Cortisone propylamine d-Methamphetamine 50 Methadone 20,000 Creatinine 60,000 Norfentanyl 20,000 Deoxycorticosterone Phenylpropanolamined,1-Tryptophan p-Hydroxymethamphetamine 400 Phencyclidine 20,000 Dextromethorphan Prednisolone 25,000 Promazine 10,000 Diclofenac Phenolbarbital 3,4-Methylenedioxymethamphetamine(MDMA) 50 Promethazine 5,000 Dicyclomine Prednisone 1- 4,000 10,000 Diflunisal d,1- Procaine 2,000 Prozine 2,500 Digoxin d- (1R,2S)-(-) 400 Cotinine (COT) Diphenhydramine Quinacrine 1-Ephedrine 400 Cotinine 50 β-Estradiol Quinine 800 Nicotine 1,500 Ethyl-p-aminobenzoate Quindine (-)Deoxyephedrine, L-Methamphetamine 3,000 Ketamine (KET) l-Epinephrine Ranitidine Ephedrine 800 Ketamine 100 Erythromycin Salicylic acid Methylenedioxymethamphetamine 50(MDMA 50) norketamine 1,000 Fenoprofen Sulfamethazine 3,4-Methylenedioxymethamphetamine HCl(MDMA) 50 Dextrolphorphan 70 Furosemide Sulindac 3,4-Methylenedioxyamphetamine HCl (MDA) 3,00 Dextrolphantartrate 70 Gentisic acid Tetracycline 3,4-Methylenedioxyethylamphetamine (MDE) 30 D-Norpropxyphene 3,000 Hemoglobin Tetrahydrocortisone, 3-acetate Morphine (MOP) Methylenedioxypyrovalerone (MDPV) Hydralazine Tetrahydrocortisone, 3- (β-d-glucuronide) Morphine 40 Methylenedioxypyrovalerone 500 Hydrochlorothiazide Codeine 10 alpha-PVP 75,000 Hydrocortisone Thiamine Ethylmorphine 24 Mephedrone 75,000 o-Hydroxyhippuric acid Hydromorphine 100 Meprobamate > 100,000 β-Hydroxynorephedrine d,1- Hydrocodone 100 D-Amphetamine 100000 Tolbutamide Levorphanol 400 +Methamphetamine 100000 () Oxycodone 25,000 (+/-)3,4-Methylenedioxymethamphetamine (MDMA) 10000 3-Hydroxytyramine Trimethoprim Morphine 3-13-d-glucuronide 50 Ibuprofen (except AMP test) Oxycodone (OXY) Cross-Reactivity Iproniazid Uric acid Oxycodone 20 (-)Isoproterenol Hydrocodone 6,250 A study was conducted to determine the cross-reactivity of the test Hydromorphone 25,000 BIBLIOGRAPHY OF SUGGESTED READING Levorphanol 12,500 with compounds spiked into drug-free PBS stock. The following components show no cross-reactivity when tested with Multi-Drug Naloxone 12,500 1. Moolchan, E., et al, “Saliva and Plasma Testing for Drugs of Naltrexone 12,500 Saliva Test Tube at a concentration up to 100µg/ml. Abuse: Comparison of the Disposition and Pharmacological Oxymorphone 100 Secobarbital 50,000 Non Cross-Reacting Compounds Effects of Cocaine”, Addiction Research Center, IRP, NIDA, Phencyclidine (PCP) NIH, Baltimore, MD. As presented at the SOFT-TIAFT Phencyclidine 10 Acetaminophen meeting October 1998. Tetrahydrozoline 50,000 Acetophenetidine Ketoprofen Marijuana (THC) Acetylsalicylic acid 2. Kim, I, et al, “Plasma and oral fluid and 11-nor-Δ9 -THC-9-COOH 12 Aminopyrine Loperamide pharmacodynamics after oral codeine administration”, Clin

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Chem, 2002 Sept.; 48 (9), pp 1486-96. 3. Schramm, W. et al, “Drugs of Abuse in Saliva: A Review,” J Anal Tox, 1992 Jan-Feb; 16 (1), pp 1-9 4. McCarron, MM, et al, “Detection of Phencyclidine Usage by Radioimmunoassay of Saliva,” J Anal Tox. 1984 Sep-Oct.; 8 (5), pp 197-201.

INDEX OF SYMBOLS

For in vitro Store between 4℃ diagnostic use only and 30℃

Keep away from Date of manufacture sunlight

Tests per kit Lot number

Keep dry Catalogue number

Do not re-use Use by

Consult instructions Authorized for use Representative

Manufacturer

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