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J. of Chromatography 1979 Vol.164 No.4 ISSN 0378-4347 VOL. 164 NO.4 DECEMBER 1,1979 (Biomedical Applications, Vol. 6, No.4) THIS ISSUE COMPLETES VOL. 164 ~.JOURNAl OF· CHROMATOGRAPHY BIOMEDICAL APPLICATIONS EDITOR, K. Macek (Prague) CONSULTING EDITOR, M. Lederer (Rome) EDITORIAL BOARD R. F. Adams (North Ryde) B. G. Belenkii (Leningrad) L. D. Bergelson (Moscow) A. A. Boulton (Saskatoon) C. J. W. Brooks (Glasgow) H. Ch. Curtius (Zurich) J. A. F. de Silva (Nutley, N.).) Z. Deyl (Prague) R. A. de Zeeuw (Groningen) J. W. Drysdale (Boston, Mass.) M. G. Horning (Houston, Texas) E. Jellum (Oslo) A. Kuksis (Toronto) H. M. Liebith (Tubingen) M. Novotny (Bloomington, Ind.) P. Padieu (Dijon) N. Seiler (Strasbourg) L. R. Snyder (Tarrytown, N.Y.) W. ). A. VandenHeuvel (Rahway, N.j.) J. Vessman (Molndal) J. Wagner (Leipzig) EDITOR, NEWS SECTION J. F. K. Huber (Vienna) I:LSEVIER SClIOI'iTIFiC PUBLISHING COMPANY AMSTERDAM PUBLICATION SCHEDULE FOR 1979 journol of Chromatography (i ncorporating Chromatographic Reviews) and journal of Chromatography, Biomedical Applications - MONTH D J F M A M JJ A S 0 N D 1978 Journal of 166/1 168/1 169 170/2 171 173/1 174/1 174/2 176/1 176/3 178/1 179/1 180/2 Chromatography 166/2 168/2 170/1 172 173/2 175/1 176/2 177/1 178/2 179/2 167 175/2 177/2 18011 Chromatographic 165/1 165/2 165/3 Reviews Biomedical 162{1 162/2 162/3 162/4 163/1 163/2 163/3 163/4 164/1 164/2 164/3 164/4 Applications -_. _._---. Scope. The journol of Chromatography publishes papers on all aspects of chromatography, electro­ phoresis and related methods. Contributions consist mainly of research papers dealing with chro­ matographic theory, instrumental development and their applications. The section Biomedical Applications, which is under separate editorship, deals with the following aspects: developments in and applications of chromatographic and electrophoretic techniques related to clinical diagnosis (including the publication of normal values); screening and profiling procedures with special refer­ ence to metabolic disorders; results from basic medical research with direct consequences in clinical practice; combinations of chromatographic and electrophoretic methods with other physico­ chemical techniques such as mass spectrometry. In Chromatographic Reviews. reviews on all aspects of chromatography, electrophoresis and related methods are published. Submission of Papers. Papers in English, French and German may be submitted, if possible in three copies. Manuscripts should be submitted to: The Editor of journal of Chromatography. P.O. Box 681. 1000 AR Amsterdam. The Netherlands or to: The Editor of journal of Chromatography. Biomedical Applications. P.O. Box 681.1000 AR Amsterdam, The Netherlands. Reviews are invited or proposed by letter to the Editors and will appear in Chromatographic Reviews or Biomedical Applications. An outline of the proposed review should first be forwarded to the Editors for preliminary discussion prior to preparation. Subscription Orders. Subscription orders should be sent to: Elsevier Scientific Publishing Company. P.O. Box 211, 1000 AE Amsterdam, The Netherlands. The journal of Chromatography, Biomedical Applications can be subscribed to separately. Publication. The journal of Chromatography (including Biomedical Applications and Chromatographic Reviews) has 19 volumes in 1979. The subscription price for 1979 (Vols. 162-180) is Df!. 2356.00 plus Df!. 285.00 (postage) (total ca. US$1288.00). The subscription price for the Biomedical Applications section only (Vols.162-164) is Df!. 384.00 plus Df!. 45.00 (postage) (total ca. US$ 209.00). journals are automatically sent by air mail to the U.S.A. and Canada at no extra costs. and to japan, Australia and New Zealand with a small additional postal charge. Back volumes of the journal of Chromatography (Vols. 1 through 161) are available at Df!. 140.00 (plus postage). Claims for issues not received should be made within three months of publication of the issue. If not, they cannot be honoured free of charge. For customers in the U.S.A. and Canada wishing additional bibliographic information on this and other Elsevier journals, please contact Elsevier/North-Holland Inc., journal Information Centre, 52 Vanderbilt Avenue, New York, N.Y. 10017. Tel: (212) 867-9040. For further information, see page 3 of cover. © ELSEVIER SCIENTIFIC PUBLISHING COMPANY -1979 All rights reserved. No part of this publication may be reproduced, stored in a retrieval system or transmitted in any form or by any means, electronic, mechanical, photocopying, recording or other­ wise, without the prior written permission of the publisher. Elsevier Scientific Publishing Company, P.O. Box 330, 1000 AH Amsterdam, The Netherlands. Submission of an article for publication implies the transfer of tht' ~opyright from the author to the publisher and is also understood to imply that the article is n,,: being considered for publication el.ier,hpr'e. .- Submission to this journal of a paper ent':ils tile aut.,o~'s Irr~v')c~ble and exclusive authorization of the publisher to collect any sums or considerations for copying or reproduction payable by third parties (as mentioned in arti~le 17 paragraph 2 of the Dutch Copyr;.ff.,t Act of 1912 and in the Royal Decree of june 20, 1974 (S. 351) pursua.nt to article 16 b ofthe D"r.ch Copyrig"~ Act ~f 1912) and/or to act 1'1 Qr Oct of Court in ~onnt!ct;c>n rherew.th. ' Print0d in Th~ Nett.(!r1al,ds VOL. 164, NO.4 JOURNAL OF CHROMATOGRAPHY DECEMBER 1,1979 (Biomedical Applications, Vol. 6, No.4) CONTENTS Simultaneous analysis of phenylglycols and phenylethanols in human urine by gas chromatography-mass spectrometry by D.J. Edwards, M. Rizk and J. Neil (Pittsburgh, Pa., U.S.A.) (Received April 10th, 1979) . 407 New procedure for isolation of amino acids based on selective hydrolysis of trimethyl­ silyl derivatives by K.L. Clay and R.C. Murphy (Denver, Colo., U.S.A.) (Received May 25th, 1979) . 417 Determination of erythrocyte amino acids by gas chromatography by W.P. Leighton, S. Rosenblatt and J.D. Chanley (New York, N.Y., U.S.A.) (Received May 18th, 1979) . 427 Determination of tryptophan and several of its metabolites in physiological samples by reversed-phase liquid chromatography with electrochemical detection by D.D. Koch and P.T. Kissinger (West Lafayette, Ind., U.S.A.) (Received August 16th, 1979) . 441 Determination of therapeutic and toxic concentrations of doxepin and loxapine using gas-liquid chromatography with a nitrogen-sensitive detector, and gas chro­ matography-mass spectrometry of loxapine by J. Vasiliades, T.M. Sahawneh and C. Owens (Birmingham, Ala., U.S.A.) (Re- ceived July 9th, 1979) . 457 Measurement of adriamycin (doxorubicin) and its metabolites in human plasma using reversed-phase high-performance liquid chromatography and fluorescence detec­ tion by R.N. Pierce and P.I. Jatlow (New Haven, Conn., U.S.A.) (Received June 1st, 1979) . 471 Reversed-phase liquid chromatographic determination of plasma levels of adriamycin and adriamycinol by S. Eksborg, H. Ehrsson and I. Andersson (Stockholm, Sweden) (Received August 6th, 1979) . 479 Spectrofluorimetric determination of dipyridamole in serum - a comparison of two methods by J.M. Steyn (Bloemfontein, Republic of South Africa) (Received August 8th, 1979) . 487 Notes Aromatic amino acids in amniotic fluid samples analyzed by reversed-phase liquid chromatography with spectrophotometric detection by A.M. Krstulovic and S. Ciriello (Purchase, N.Y., U.S.A.) and L. Bertani-Dziedzic and S.E. Gitlow (New York, N.Y., U.S.A.) (Received August 6th, 1979) ...... .. 495 (Continued overleaf) " - Contents (continued) Rapid liquid chromatographic determination of tryptophan, tyrosine, 5-hydroxy­ indoleacetic acid and homovanillic acid in cerebrospinal fluid by G.M. Anderson, J.G. Young and D.J. Cohen (New Haven, Conn., U.S.A.) (Re­ ceived August 6th, 1979) ..................................... .. 501 High-performance liquid chromatography of hemoglobins. I. Determination of hemo­ globin A 2 by K.M. Gooding, K.-C. Lu and F.E. Regnier (West Lafayette, Ind., U.S.A.) (Re- ceived March 27th, 1979) ........ '. 506 Gas chromatographic determination of (o-methyl-o<-phenylbenzyloxy)acetic acid levels in human serum following therapeutic doses of orphenadrin (Disipal®) by J. Huisman and L.L. Liebregt (Amersfoort, The Netherlands) and J.H.H. Thyssen (Utrecht, The Netherlands) (Received August 6th, 1979) ................ .. 510 Simultaneous determination of disopyramide and its mono-N-dealkylated metabolite in plasma by gas-liquid chromatography by M.-L. Aitio (Turku, Finland) (Received August 6th, 1979) ............. 515 Determination of 1-diethylcarbamoyl-4-methylpiperazine (diethylcarbamazine) in human plasma and urine by G.D. Allen, T.M. Goodchild and B.C. Weatherley (Beckenham, Great Britain) (Received August 6th, 1979) 521 Determination of the diuretic triamterene in the plasma and urine of humans by high­ performance liquid chromatography by R.R. Brodie, L.F. Chasseaud, T. Taylor and L.M. Walmsley (Huntingdon, Great Britain) (Received August 6th, 1979) I......... .. 527 Determination of naftidrofuryl in the plasma of humans by hig~-performanceliquid chromatography by R.R. Brodie, L.F. Chasseaud and T. Taylor (Huntingdon, Great Britain) and J.O. Hunter and P.J. Ciclitira (Cambridge, Great Britain) (Received May 16th, 1979) .................................................. .. 534 High-performance liquid chromatographic determination of glipizide and some other sulfonylurea drugs in serum by E. W~lin-Boll and A. Melander (Malmo and Dalby, Sweden) (Received May 16th, 1979) ............................................... 541 Book Reviews Biological and biomedical applications of isoelectric focusing (edited by N. Catsim­ poolas and J. Drysdale), reviewed by Z. Deyl ........................ .. 547 Affinity chromatography (edited by O. Hoffmann-Ostenhof, M. Breitenbach, F. Koller, D. Kraft and O. Scheiner), reviewed by J. Turkova 548 Author Index. 550 Subject Index 555 7his journal nowayailable on MICROFILM Back volumes up to the end of the 1978 subscription year may be obtained on microfilm • Annual Updates - By summer of each year updates of all journals completing 4 or more volumes since the last update will be­ come available on microfilm.
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