Inhibitors Product Data Sheet

Levomefolic acid • Agonists

Cat. No.: HY-14781 CAS No.: 31690-09-2

Molecular Formula: C₂₀H₂₅N₇O₆ •

Molecular Weight: 459.46 Screening Libraries Target: Endogenous Metabolite; Reactive Oxygen Species Pathway: Metabolic Enzyme/Protease; Immunology/Inflammation; NF-κB Storage: Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month

SOLVENT & SOLUBILITY

In Vitro H2O : 5 mg/mL (10.88 mM; Need ultrasonic) DMSO : < 1 mg/mL (insoluble or slightly soluble)

Mass Solvent 1 mg 5 mg 10 mg Concentration Preparing 1 mM 2.1765 mL 10.8823 mL 21.7647 mL Stock Solutions 5 mM 0.4353 mL 2.1765 mL 4.3529 mL

10 mM 0.2176 mL 1.0882 mL 2.1765 mL

Please refer to the solubility information to select the appropriate solvent.

BIOLOGICAL ACTIVITY

Description Levomefolic acid (5-MTHF) is the natural, active form of folic acid used at the cellular level for DNA reproduction, the cysteine cycle and the regulation of homocysteine among other functions. IC50 value: Target: Folate analogLevomefolic acid has been proposed for treatment of cardiovascular disease and advanced cancers such as breast and colorectal cancers. Levomefolic acid (5-MTHF) has the prominent antioxidant activity. A high dose of 5-MTHF or folic acid does not influence Natural killer (NK) cell function in vitro.

CUSTOMER VALIDATION

• J Mol Med (Berl). 2019 Aug;97(8):1183-1193.

See more customer validations on www.MedChemExpress.com

Page 1 of 2 www.MedChemExpress.com REFERENCES

[1]. Hirsch S, et al. Natural killer cell cytotoxicity is not regulated by folic acid in vitro. Nutrition. 2013 Jan 9. pii: S0899-9007(12)00404-2.

[2]. Liu Y, Green TJ, Wong P, Kitts DD. Microencapsulation of L-5-methyltetrahydrofolic Acid with ascorbate improves stability in baked bread products. J Agric Food Chem. 2013 Jan 9;61(1):247-54.

[3]. Merola N, Alonso FJ, Ros G, Castón MJ. Antioxidant activity comparison between [6S]-5-methyltetrahydrofolic acid calcium salt and the related racemate form. Food Chem. 2013 Jan 15;136(2):984-8.

[4]. Liu Y, Tomiuk S, Rozoy E, et al. Thermal oxidation studies on reduced folate, L-5-methyltetrahydrofolic acid (L-5-MTHF) and strategies for stabilization using food matrices. J Food Sci. 2012 Feb;77(2):C236-43.

[5]. Bashir M Rezka, Guido R.M.M Haenena, Wim J.F van der Vijgha, et al. Tetrahydrofolate and 5-methyltetrahydrofolate are folates with high antioxidant activity. Identification of the antioxidant pharmacophore. 2003,555(3):601-605.

[6]. Levomefolic acid

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Caution: Product has not been fully validated for medical applications. For research use only. Tel: 609-228-6898 Fax: 609-228-5909 E-mail: [email protected] Address: 1 Deer Park Dr, Suite Q, Monmouth Junction, NJ 08852, USA

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