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FDA-APPROVED DRUGS TO TREAT SCHIZOPHRENIA

Generic (Brand) Name Indications Formulations Notable Side Effects ATYPICAL ANTIPSYCHOTIC DRUGS

Aripiprazole (Abilify®) Schizophrenia, Tablet, orally disintegrating tablet, short- Dizziness, insomnia, akathisia, activation, nausea, vomiting, sedation acute agitation acting intramuscular injection

(Abilify Discmelt®) Schizophrenia Orally disintegrating tablet

(Abilify Maintena®) Schizophrenia Long-acting intramuscular injection

Asenapine (Saphris®) Schizophrenia Orally disintegrating tablet May increase risk for diabetes and dyslipidemia, EPS (dosage dependent), hyperprolactinemia (dosage dependent), sedation, weight gain, akathisia, neuroleptic malignant syndrome, tardive dyskinesia

Clozapine (Clozaril®, Treatment-resistant Tablet, orally disintegrating tablet Increases risk for diabetes and dyslipidemia, increased salivation Leponex®) schizophrenia, (possibly severe), sweating, agranulocytosis, sedation, weight gain, suicidal behavior constipation, hypotension, seizures associated with schizophrenia

Iloperidone (Fanapt®) Schizophrenia Tablet May increase risk for diabetes and dyslipidemia, EPS (dosage dependent), hyperprolactinemia (dosage dependent), sedation, weight gain, akathisia, neuroleptic malignant syndrome, tardive dyskinesia

Lurasidone (Latuda®) Schizophrenia Tablet May increase risk for diabetes and dyslipidemia, EPS (dosage dependent), hyperprolactinemia (dosage dependent), sedation, weight gain, akathisia, neuroleptic malignant syndrome, tardive dyskinesia

Olanzapine (Zyprexa®) Schizophrenia, Tablet, orally disintegrating tablet, short- Increases risk for diabetes mellitus and dyslipidemia, sedation, acute agitation acting intramuscular injection weight gain, hyperprolactinemia, constipation, hypotension, seizures

(Zyprexa® Relprevv™) Schizophrenia Long-acting intramuscular injection

(Zyprexa® Zydis®) Schizophrenia Orally disintegrating tablet

Paliperidone Schizophrenia, Tablet May increase risk for diabetes and dyslipidemia, EPS (dosage (Invega®) schizoaffective dependent), hyperprolactinemia (dosage dependent), sedation, disorder weight gain, tachycardia, headache

(Invega® Sustenna®) Schizophrenia Long-acting intramuscular injection

Quetiapine (Seroquel®, Schizophrenia Tablet May increase risk for diabetes and dyslipidemia, dizziness, sedation, Seroquel® XR) weight gain, constipation, hypotension

Risperidone Schizophrenia Tablet, orally disintegrating tablet, oral May increase risk for diabetes and dyslipidemia, EPS (dosage (Risperdal®) solution, long-acting intramuscular dependent), hyperprolactinemia (dosage dependent), sedation, injection weight gain, akathisia, neuroleptic malignant syndrome, tardive dyskinesia (Risperdal® Consta®) Schizophrenia Long-acting intramuscular injection

(Risperdal® M-Tab®) Schizophrenia Orally disintegrating tablet

Ziprasidone (Geodon®) Schizophrenia, Capsule, short-acting Possible activating side effects at very low to low dosages, sedation, acute agitation intramuscular injection hypotension, akathisia Continued on back. # Continued from front. & Clip doi:10.3928/02793695-20131106-79 information andreviewed by apsychiatrist before publication. Available prescribing product whichis information was also usedinthecreation ofthischart, Sources. Stahl, S.M.(2006). treatments forpatients. sourceDisclaimer. isforeducational ofdrug information whenprescribing usedasaprimary onlyandshouldnotbe purposes The informationinthischart a mutually misciblesolvents. given to thepatient;oral liquiddosageformthatcontains solution=homogeneous oneormore chemical substances dissolved inasolvent of ormixture liquid thatcontains dissolved medications; oral concentrate =liquidpreparation ofincreased strength andreduced volume thatisusually diluted before seconds, whenplaced onorunderthetongue; inhalationpowder =medication elixir=sweetened, released into thelungsviaaninhaler; hydroalcoholic Key. Tablet =Medication pressed orcompacted into asolidto swallowed; be orally disintegrating tablet=disintegrates rapidly, usually withinamatter of Note. EPS=extrapyramidal symptoms. (Stelazine Trifluoperazine (Navane Thiothixene (Mellaril Thioridazine (Compazine Prochlorperazine (Orap Pimozide (Trilafon Perphenazine Molindone (Adasuve Loxapine Haloperidol (Prolixin Fluphenazine (Thorazine Chlorpromazine CONVENTIONAL ANTIPSYCHOTIC DRUGS Generic (Brand)Generic Name Does nothave FDA Does approval forthisindication. FDA-APPROVEDDRUGS TO TREATSCHIZOPHRENIA Save: ® ) ® ® ® ® ) ) ® ) ) ® ) (Loxitane

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Schizophrenia Schizophrenia Schizophrenia Schizophrenia Tourette’s syndrome Schizophrenia Schizophrenia Schizophrenia acute agitation Schizophrenia, Schizophrenia acute agitation Schizophrenia, Schizophrenia acute agitation Schizophrenia, Indications Essential psychopharmacology: Essential psychopharmacology: The prescriber’s guide a

, Capsule, short-acting intramuscular Capsule, short-acting Tablet, oral concentrate intramuscular injection Tablet, suppository, short-acting Tablet intramuscular injection Tablet, oral concentrate, short-acting Tablet Inhalation powder intramuscular injection Capsule, oral concentrate, short-acting intramuscular injection acting long- intramuscular injection, short-acting Tablet, oral concentrate, intramuscular injection long-acting intramuscular injection, acting Tablet, oral concentrate, oral elixir, short- intramuscular injection short-acting Tablet, capsule, oral solution,suppository, intramuscular injection Tablet, oral concentrate, short-acting injection medications for psychiatric illnesses information oncurrentA handysource ofup-to-date Formulations

(Rev., updated ed.). New York: Cambridge Press. University sedation, hypotension, constipation, hyperprolactinemia, dystonia Neuroleptic malignant syndrome, akathisia, EPS,tardive dyskinesia, dystonia, sedation, hypotension, constipation, hyperprolactinemia Neuroleptic malignant syndrome, akathisia, EPS,tardive dyskinesia, syndrome, EPS,akathisia, tardive dyskinesia, dystonia Sedation, weight gain,hyperprolactinemia, neuroleptic malignant hyperprolactinemia, photosensitivity dyskinesia, sedation, weight gain,hypotension, constipation, Neuroleptic malignant syndrome, akathisia, EPS,tardive sedation, hypotension, constipation, hyperprolactinemia, dystonia Neuroleptic malignant syndrome, akathisia, EPS,tardive dyskinesia, sedation, hypotension, constipation, hyperprolactinemia, dystonia Neuroleptic malignant syndrome, akathisia, EPS,tardive dyskinesia, hypotension, constipation, hyperprolactinemia, dystonia retinopathypigmentary (at highdosages), sedation, weight gain, Neuroleptic malignant syndrome, akathisia, EPS,tardive dyskinesia, EPS, akathisia, tardive dyskinesia, dystonia Hypotension, hyperprolactinemia, neuroleptic malignant syndrome, dystonia neuroleptic malignant syndrome, EPS,akathisia, tardive dyskinesia, Sedation, constipation, hypotension, hyperprolactinemia, hyperprolactinemia, dystonia dyskinesia, sedation, weight gain,hypotension, constipation, Neuroleptic malignant syndrome, akathisia, EPS,tardive sedation, constipation, hyperprolactinemia, dystonia Neuroleptic malignant syndrome, akathisia, EPS,tardive dyskinesia, Altered taste, sedation updated annually with the mostcurrently available Notable SideEffects

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