Multiple Testing Because It Was Booked Out

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Target Group Accommodation Accommodation and food are included in the registra- This is the sixth in a series of annual Summer schools which target people interested in planning and analyzing, e.g. clinical tion fees. studies. Basic knowledge in statistical methodology and work- Universität Salzburg ing skills in using R are assumed and required. How to Get There Deutsche und Österreich-Schweizer Region der

Please see the description (in German) at Time and Date Internationalen Biometrischen Gesellschaft http://www.bifeb.at/ihr-aufenthalt/anreise/ (IBS-DR, ROeS) Tuesday 6 July until Friday 9 July 2021  Please arrive on Tuesday by 14:30 Österreichische Statistische Gesellschaft (ÖSG) Contact & Information  Course finishes Friday by 12:30 For questions, please ask Location Andrea Baumgartner or Arne Bathke Bundesinstitut für Erwachsenenbildung (bifeb) Bürglstein 1-7 Universität Salzburg 5360 Strobl, Austria Hellbrunner Str. 34 5020 Salzburg, Austria Registration / Waiting List Tel. +43 (0)662 8044 5302 Please submit your request for registration by 31 March 2021 [email protected] Summer School 2021 via email to:

Andrea Baumgartner, [email protected]

Please also indicate if you had tried to register for one of the previous Summer Schools in Strobl but could not be admitted Multiple Testing because it was booked out.

Registration Fees 6 – 9 July, 2021 Strobl am Wolfgangsee, Austria Membership in one of the sponsoring societies is mandatory. Please note that some of the societies offer free student Cancellation membership. Due to the unpredictable Covid situation, we are offering a Academic / Government: 410 Euro more generous cancellation policy this year: Your registra- Instructors Business / Industry: 570 Euro tion will only become binding on 31 May 2021. Student: 280 Euro Werner Brannath (Bremen) If you have to cancel, we will try to admit someone from the Thorsten Dickhaus (Bremen) waiting list. However, if this it not possible and your cancellation is on 1 June 2021 or later, your registration fees can- Ludwig Hothorn (Hannover) not be returned. Robin Ristl (Wien)

Whenever more than one particular question is Introduction High-Dimensional Multiple Testing targeted simultaneously using statistical inference procedures, we are in the realm of multiple Robin Ristl, Wien Thorsten Dickhaus, Bremen testing, or multiple comparisons. And, since look- ing at different things simultaneously is rather In this part, we will introduce basic termi- We will present methods for high-dimensional mul- the rule than the exception, profound knowledge nology, concepts, and methods associated tiple testing problems. Special focus will be laid on on how to correctly and validly adjust for multi- with multiple testing, such as type-I-error multiple tests controlling the false discovery rate plicity in inference is paramount for good statisti- inflation and family wise error rate, the (FDR). Applications in genetics and other life scienc- cal practice and research reproducibility. closed-testing principle, as well as different es will be discussed. single-step and multi-step p-value adjust-

The 2021 Summer School in Strobl revisits the ments. basics of multiple testing and then focuses on Applying the max-T-Test and Multiple Mar- different particular aspects and methods such as ginal Models in Preclinic, Clinic, and Epide- graphical test procedures, high-dimensional mul- Graphical Test Procedures and Sim- miology tiple testing, and other approaches to tackle ultaneous Confidence Intervals complex multiplicity challenges. The topics will Ludwig Hothorn, Hannover range from practice-oriented to methodological. Werner Brannath, Bremen Combining two approaches, the maxT test and mul-

The presenters are well-known authorities on tiple marginal methods (both available in the R- To enable confirmatory claims for several multiple testing, and there will be plenty of room package multcomp), allows the solution of complex primary and secondary endpoints, rather for informal discussions with the experts. multiple issues: analysis of multiple correlated, dif- complex multiple testing approaches have ferently-scaled endpoints, multiple times (for infer- been suggested for clinical trials. The optional social program includes a visit to a ence), multiple test statistics, multiple effect sizes Starting with hierarchical testing, we will local award-winning Edelbrand distillery (if the and trend tests considering 'dose' both quantitative- give an introduction to serial and parallel Covid situation allows) and a barbecue evening. ly (as covariate) and qualitatively (as factor). gatekeeping, graphical test procedures and

related testing approaches using clinical On the conference site, there are options for var- trial examples. Simultaneous confidence ious outdoor activities (jogging, football, swim- Lab Exercises Intervals for these complex test procedures ming,…), and participants regularly bring their will also be addressed. portable music instruments along for impromptu Some sessions involve hands-on examples using R. performance sessions. Please bring your own laptop, with R / Rstudio in-

stalled. We will inform you ahead of time regarding

the installation of certain packages.