Medical University of Graz

Medical University of Graz YOUR PARTNER IN MEDICAL RESEARCH Medical University of Graz

The university applies a proactive approach ounded in 2004, the Medical University of Doctoral Studies in Medical Sciences, PhD to research management by involving re- Graz is a young university rooted in histo- Programs) and post-graduate programs (e.g. F searchers in international initiatives. The ric ground, as it succeeds the Medical Faculty Public Health). university participates in numerous projects of Karl-Franzens University Graz, which was within the EU Framework Programs and also established in 1863. Research activities cover a broad spectrum of acts as coordinator in several EU-funded pro- clinical and pre-clinical fields, with a special jects. The Medical University of Graz comprises 16 focus on the research areas of Neurosciences, Research Institutes and 23 Clinical Depart- Oncology, Cardiovascular Research, and The Medical University of Graz attaches ments as well as a state-of-the-art Center Molecular Bases of Lipid-Associated Diseases. great importance to quality management and for Medical Research. The number of em- The research profile is also characterized by quality assurance and holds relevant quality ployees is about 1700. Approximately 4500 the topics of biobanking and biomarker re- certifications for all of its spheres of work. students are enrolled in programs of study search and by the cross-sectional theme of (Human Medicine, Dentistry, Nursing Science, sustainable health research. Institutes, Departments & Centers >> Department of Surgery – Division of Neonatology – Division of General Surgery – Respiratory and Allergic Disease Division – Division of Vascular Surgery >> Department of Pediatric and Adolescent Surgery – Division of Cardiac Surgery – Division of General Pediatric Surgery Pre-Clinical Sector – Division of Plastic, Esthetic and Reconstructive – Division of Pediatric Orthopedics >> Institute of Physiology Surgery >> Department of Medical Psychology and >> Institute of Biophysics – Division of Thoracic and Hyperbaric Surgery Psychotherapy >> Institute of Physiological Chemistry – Division of Transplantation Surgery >> Department of Neurosurgery >> Institute of Molecular Biology and Biochemistry >> Department of Dermatology and Venereology >> Department of Neurology >> Institute of Pathophysiology and Immunology – Division of General Dermatology – Division of General Neurology >> Institute of Cell Biology, Histology and Embryology – Division of Environmental Dermatology and – Division of Special Neurology >> Institute of Experimental and Clinical Venereology >> Department of Orthopedic Surgery Pharmacology >> Department of Obstetrics and Gynecology >> Department of Psychiatry >> Institute of Anatomy – Division of General Gynecology >> Department of Radiology >> Institute of Forensic Medicine – Division of Obstetrics and Maternal Fetal – Division of General Radiological Diagnostics >> Institute of Human Genetics Medicine – Division of Vascular and Interventional >> Institute of Hygiene, Microbiology and Radiology Environmental Medicine Clinical Sector – Division of Pediatric Radiology >> Institute of Pathology >> Department of Otorhinolaryngology – Division of Nuclear Medicine Radiology >> Institute of Social Medicine and Epidemiology – Division of General Otorhinolaryngology, Head – Division of Neuroradiology >> Institute for Medical Informatics, Statistics and and Neck Surgery >> Department of Therapeutic Radiology and Documentation – Division of Neuro-Otology Oncology >> Institute of Nursing Science – Division of Phoniatrics, Speech and Swallowing >> Department of Trauma Surgery >> Department of Internal Medicine >> Department of Urology Clinical Sector – Division of Angiology >> Department of Dentistry and Maxillofacial Surgery >> Department of Anesthesiology and Intensive Care – Division of Endocrinology and Metabolism – Division of Orthodontics and Maxillofacial Medicine – Division of Gastroenterology and Hepatology Orthopedics – Division of General Anesthesiology and – Division of Hematology – Division of Prosthodontics, Restorative Intensive Care Medicine – Division of Cardiology Dentistry, Periodontology and Implantology – Division of Anesthesiology for Cardiovascular – Division of Nephrology and Hemodialysis – Division of Preventive and Operative Dentistry, Surgery and Intensive Care Medicine – Division of Oncology Endodontics, Pedodontics and Minimally – Division of Anesthesiology for Neurosurgical – Division of Pulmonology Invasive Dentistry and Craniofacial Surgery and Intensive Care – Division of Rheumatology and Immunology – Division of Oral and Cranio-Maxillofacial Medicine >> Department of Pediatrics and Adolescent Medicine Surgery >> Department of Ophthalmology – Division of General Pediatrics >> Clinical Institute of Medical and Chemical >> Department of Blood Group Serology and – Division of Pediatric Hemato-Oncology Laboratory Diagnostics Transfusion Medicine – Division of Pediatric Cardiology >> Clinical Psychosomatics The Biobank Graz includes: Biobank A cross-sectional biobank – containing essentially unselected pathological samples and clinical data from the Styrian populati- The core asset of Biobank Graz is a large collection of clinical samples on, representing all detected diseases at their natural frequency – actually one of the largest in Europe – comprising millions of well- of occurrence. organized tissue, blood and DNA samples. A disease-focused clinical biobank – providing different types Moreover, Biobank Graz provides powerful logistics and infrastructure enabling the prospective collection of samples and data to be designed of human biological samples of the highest quality and with for the needs specified by customers. detailed clinical follow-up data during the whole course of Its mission is to support research on the cause of disease and the devel- disease, including long term observation for specifically selected opment of improvements in disease diagnosis and treatment. The goal diseases and targeted disease groups. Disease-focused collecti- is to contribute to the improvement and sustainability of healthcare for ons are based on the major research interests of cooperating the general population. Samples from selected patients and donors at institutions. the university hospital who have signed an informed consent declara- tion are deposited in the Biobank Graz. This means that excess tissue and blood samples are collected and placed in storage. The samples Services provided by the Biobank Graz: are harvested in the course of routine interventions done by differ- >>Project development and project coordination ent departments and divisions of the hospital and approved for use in >>Provision of samples and data research projects only after the completion of all necessary laboratory >>Preparation of derivatives (e.g. nucleic acid extraction, etc.) and histopathological analyses. >>Data pre-processing and clearing The Biobank Graz currently contains more than 4.5 million samples, >>Quality assurance measures thus representing a non-selected patient group characteristic of central >>Prospective sample collection; planning and realization of Europe. The Biobank Graz operates a quality management system ac- prospective study cohorts cording to ISO 9001:2008. >>Contact to and networking with other biobanks Graz is home to the headquarters of the European Research Infra- >>Integration of pre-existing collections into the Biobank Graz structure Consortium (ERIC) “Biobanking and Biomolecular Research >>Information for the respective personnel groups/advanced Resources Infrastructure” (BBMRI), which functions at the interface and continued education between biological specimens and data from European patients and >>Consulting and training (legal, ethical, technical and top-level biomedical research. organisational aspects of biobanking) www.medunigraz.at/biobank >>Support at the installation of new biobanks http://bbmri.eu/ LSH 3

MORGEN EPIC LifeLines

MORGEN HP-CVDRF ACS

NLCS BMB KompNet

PBCCBF

PBCCCM

Banu BB

BioPIC NCT

CEPH TUM

CRB Bichat BB MUG

BNA DN GRAZ

Surface is proportional to number of samples

Tissue, Blood, DNA

CNIO Blood, DNA

Biobank 06 BBI ZONCO 3 CNESPS TBGI

25 Biobanks with the highest number of samples. Data source: www.bbmri.eu, April 2009 Center for Medical Research Core Facilities >> CF Molecular Biology The Center for Medical Research (ZMF) at the Medical University of >>CF Mass Spectrometry Graz was established in 2004 in order to provide first-class biomedi- >>CF Microscopy cal research infrastructure for clinicians and basic research scientists. >CF Flow Cytometry Housed within a purpose-built, state-of-the-art building at the heart > of the university hospital campus, the Center comprises more than >>CF Ultrastructure Analysis 4000m² of well-equipped laboratory and office space catering to cut- >>CF Clinical Research Center ting edge basic and applied biomedical and clinical research. >>General & Special Laboratory Facilities Considerable effort has been invested into the development of a mod- >>Cell Culture Facility ular organisational structure to maximize the efficiency and effective- >>Bioinformatics ness of research conducted at the ZMF. Well-equipped conventional >>Biostatistics laboratories and four Core Facilities (Molecular Biology, Mass Spec- >>Seminar Rooms trometry, Microscopy and Biophysics and Flow Cytometry) with the >>ZMF Academy most up-to-date equipment and well-trained technical staff are available to all researchers. Restricted Access Laboratories cater to experi- mentation requiring special safety measures. A distinct feature of the ZMF is a shared Clinical Research Center enabling high quality clinical studies. In addition, the Center boasts the assistance of a Biostatistics Division expert in experimental design and data analysis, whilst an Au- diovisual unit offers state of the art media solutions for optimal data communication. The first-call permanent staff (experienced scientists, skilled techni- cians, and administrative personnel) provides assistance to investi- gators at all stages of the research process, including experimental design, method development, high-throughput sample work-up and data interpretation and presentation.

http://www.medunigraz.at/zmf/

Centre for Knowledge and 10,800 m² for science and industry Technology Transfer in Medicine Advantages of the ZWT (ZWT) >>High-quality, state-of-the-art laboratory, office and communications space >Flexible room layout in laboratories and offices The Centre for Knowledge and Technology Transfer in Medicine > (ZWT) is the first Austrian technology and research centre to achieve >>Immediate access to core facilities on the MED CAMPUS/ full physical and organisational integration into a university campus. Center for Medical Research (ZMF) The ZWT thus offers the perfect venue for cooperation between sci- >>Existing workplace approval for S1 and S2 laboratory use ence and industry. >>Special infrastructure for microenterprises The ZWT is meant to enable cooperation projects between science and >>Special infrastructure for spin-offs (Life Sciences Incubator) industry (mainly in the field of life sciences) on an area of around 9,100 >>Meeting rooms, kitchenettes, bistro m² above ground and 1,700 m² underground. >>Professional facility management The business areas offer optimum conditions for promising work: laboratories with adaptive basic equipment, modern offices and sufficient Technology space for communications infrastructure (conference zones, a café, >>8 x air-renewal with optimised, free cooling potential etc.). >>User-specific utilities (nitrogen, compressed air, etc.) Around half of the ZWT’s available state-of-the-art spaces can be rent- >>Optimum ceiling height for laboratories ed by interested firms from the life sciences sector. >>Ventilated storage area for hazardous substances The ZWT will also house a Life Science Incubator for spin-offs and >>Fibre-optic internet connection start-up companies in the area of life sciences (e.g. pharma, biotech- nology, medical technology). By offering lab and office space, access Building technology to research infrastructure, research and clinical expertise and a wide >>Design meets low energy standards portfolio of services, the Incubator supports young entrepreneurs in >>Electronically controlled sun protection developing their innovative companies. >>Daylight-dependent lighting control The ZWT offers a wide range of benefits. Scientific, economic and -ar >>Emergency-powered ventilation chitectural aspects contribute to the fact that the ZWT - in its own way - represents a unique range of enterprises in the life sciences. http://www.zwt-graz.at/ © Riegler Riewe University Hospital Fact Box >> 390,000 out-patients per year The clinical departments and divisions of the Medical University of >>80,000 in-patients per year Graz are embedded in the hospital complex of the Landeskranken- >>1.2 million treatments per year haus-Univ.Klinikum Graz” (University Hospital Graz), the only tertiary >810,000 treatments for out-patients care hospital in the south of Austria. > >>400,000 treatments for in-patients The LKH University Hospital Graz not only provides basic health ser- >>1,500 beds vices in the metropolitan area of Graz, but also serves as a central – 1,400 general care hospital for the state of Styria and University Hospital for the south of – 17 day clinic Austria. It encompasses all medical disciplines. – 130 intensive care

Since 2011, the University Hospital has been jointly directed by the regional holding of public hospitals on the one hand and the Medical University on the other. This joint governance is based on a cooperation contract between both organizations and ensures that patient care, teaching and research are organized in a coordinated and ef- ficient way.

University Hospital: www.lkh-graz.at Comprehensive Cancer Center Graz: www.ccc-graz.at

Cooperation Fact Box BioTechMed As an institution, the Medical University of Graz is involved in a wide Interuniversity cooperation between the Medical University of spectrum of more than 200 contractually concluded collaborations with Graz, the Graz University of Technology and the University of national institutions, EU partners and international partners worldwide. Collaborating partners include universities and large companies as well Graz as SMEs. In part, the EU-Framework Programs form the basis for these www.biotechmed-graz.at collaborations, i.e. the university is also well-versed in working within and coordinating collaborations in this context. The University’s Inter- EURAXESS national Office and Research Management Unit provide support ser- network of more than two hundred centres and service points vices for international cooperations. for researcher mobility located in 35 European countries http://ec.europa.eu/euraxess/# The University encourages researcher mobility and takes numerous measures to support national cooperations, collaboration with EU EURASIA-PACIFIC-UNINET partners as well as internationalization. Among others, it offers finan- network aims at establishing partnerships between Austrian cial support for research stays through the Visiting Scientists Program universities and institutions in East, Central, and South Asia and sponsored by Bank Austria Unicredit Group. the Pacific region http://www.eurasiapacific.net/

Bank Austria Visiting Scientists Program http://www.medunigraz.at/ba

Member of > Cluster human.technology.styria http://www.humantechnology.at/ > Science Park Graz (academic incubator) http://www.sciencepark.at

> 30 ongoing EU-funded projects Cooperation in publications (2012) Research Management & Services Provided Information >> Information about open calls for applications >>Organization of info events and workshops Several units in the Medical University of Graz offer a wide spectrum >>Proposal Checks of research-related services to ensure that researchers can dedicate as >>Budget planning much time as possible to their research interests and activities: >>Financial Project Reporting (Cost Statements) > Research Management Unit >>Organization of Audits – Research Services and Technology Transfer >>Checking and Drafting of Contracts, Legal Advice – Research Documentation and Evaluation >>Technology Transfer (marketing, patenting, licensing) > Coordination Center for Clinical Trials >>Coordination Center for Clinical Trials > Center for Medical Research (Core Facilities) >>Proofreading and Translation Service > Institute of Medical Informatics, Statistics and Documentation >>Project Management Services > Legal, Personnel and Finance Departments >>Statistics Support > Personnel Development Unit >>Financial Support for Open Access Publications > Ethics Committee >>Research-related programs in continuing education (Scientific Writing, Good Scientific Practice etc.) The University runs a comprehensive Research Information System >Good Scientific Practice Committee including information on researchers, projects, publications, and co- > operation activities: >>Ethics Committee http://research.medunigraz.at

Contact

Medical University of Graz Research Management Unit Phone: +43 316 385 72033 [email protected]

Research Information System: http://research.medunigraz.at