R&D Pipeline Update

R&D Pipeline Update The Beginning of What‘s Next

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Capital Markets Day March 10-11, 2021

Bob Reiter Head of R&D, Crop Science Division

35 Cautionary Statements Regarding Forward-Looking Information

This presentation may contain forward-looking statements based on current assumptions and forecasts made by Bayer management.

Various known and unknown risks, uncertainties and other factors could lead to material differences between the actual future results, financial situation, development or performance of the company and the estimates given here. These factors include those discussed in Bayer’s public reports which are available on the Bayer website at http://www.bayer.com/.

The company assumes no liability whatsoever to update these forward-looking statements or to conform them to future events or developments.

2 /// Bayer Capital Markets Day /// The Beginning of What‘s Next /// March 10-11, 2021 1 R&D Strategic Priorities

R&D Strategic Priorities Delivering World Class Innovation

1 Pursuing sustainable innovation to shape the future of agriculture

2 Delivering the leading R&D pipeline in scale, productivity and value

3 Leading the development of next-generation biotech traits

4 Optimizing large and diverse germplasm library with advanced breeding technologies

5 Advancing new approaches in small molecule and biologicals

6 Unlocking opportunities for new business models, powered by data science

3 /// Bayer Capital Markets Day /// The Beginning of What‘s Next /// March 10-11, 2021 2 Leadership

Unmatched R&D Investment Powers Industry-Leading Portfolio Shaping the Future of Agriculture with Sector’s Most Productive Innovation Platform

Ag R&D Investment (€bn)3 R&D Platform #1 in Crop Science

2.0

1.2 1.0 0.8

• Fueled by ~7,100 R&D employees2 in >50 countries Bayer Crop Science Syngenta + Adama1 Corteva BASF Ag

Ag Chem Seed & Traits

1 Represents the legacy Syngenta results plus Adama. Excludes non-agro business sales of ADAMA (nutritional supplements, aromatic products, industrial products). Syngenta Group formal reporting did not begin until H1 2020. 2 Includes permanent and temporary employees 3 Company information ; exchange rate: FY 2019: ~1.14 USD/EUR. 2020 Reported results for all companies except Syngenta = 2019 reported results. Bayer R&D excludes impairment charges.

4 /// Bayer Capital Markets Day /// The Beginning of What‘s Next /// March 10-11, 2021 2 Leadership

>100 Technology Agreements Fuel Open Innovation Model From LEAPS to Licensing, Partnerships Power the Ability to Drive Disruptive and Iterative Innovation

Partner of choice, with >100 technology collaborations, customer-sponsored research initiatives, venture capital agreements and crowdsourcing powering our open innovation model

Sustainable Protein Supply Sustainable Ag Services and Inputs

Solutions to Help Farmers Control Crop Threats

Breakthrough Biology and Next Generation Genomics Transformational Technology/AI Unlocking New Research and Business Models

5 /// Bayer Capital Markets Day /// The Beginning of What‘s Next /// March 10-11, 2021 2 Leadership

Breadth and Depth of Five Core R&D Platforms Power Innovation Convergence of Leading R&D Platforms to Unlock Next Layer of Value Creation in Agriculture

BEST-POSITIONED TO DISCOVER, COMBINE AND TAILOR SOLUTIONS FOR GROWERS

SEEDS & TRAITS CROP PROTECTION DIGITAL AG Breeding Biotech Chemistry Biologicals Data Science

Leading germplasm Extensive protein libraries Strong discovery database of grower libraries and leaders in protein platform for molecules 270,000 microbes #1 and field trial seed Advanced breeding and optimization technology with new modes-of-action in collection and differentiated profiles performance data in the data science technology First to combine RNAi industry application technology with biotech >100,000 2x new small molecule strains characterized every 1.7P calculations >1.5bn datapoints candidates in discovery year with in silico, in vitro >69bn data points of in cloud-based generated by Precision since 2015 and in planta assays product performance under algorithms Genomics team to deliver real-world farmer biotech traits and accelerate 30-60 molecules >1,400 trials management practices >3,200 unique genetic gain selected for field trials in 38 countries in 2020 field testing locations a year new and next-gen. >20 ~80m acres >150m subscribed traits in development Expect >430 deployments ~100 of commercial products in acres across 23 countries annually in corn, new formulations to launch row crops annually soybeans, vegetables Reach >350m in the next decade acres annually

6 /// Bayer Capital Markets Day /// The Beginning of What‘s Next /// March 10-11, 2021 2 Leadership

Meaningful Advancement of Most Valuable R&D Pipeline in Ag in 2020 Converting Industry Leading Investment into New Products for Farmers

Total crop protection Value of Up to €30bn registrations in 2020 1 + >200 in Peak Sales 430 New crop protection ~50% Incremental New hybrids and varieties formulations launched deployed across corn, soybeans 10 New crop protection and vegetables 8 actives advanced

Biotech traits projects 3 advanced to launch phase; models Intacta 2 Xtend, ground- 2 advanced breaking ThryvOn Technology and Corn New model-based pipeline Corn Soybeans Rootworm 3 mgmt. process deployed 2020 Herbicides Fungicides Insecticides Other

1 Represents non-risk adjusted estimated peak sales for the combined breeding, biotech, crop protection and environmental science pipelines, as well as new business models and new value areas.

7 /// Bayer Capital Markets Day /// The Beginning of What‘s Next /// March 10-11, 2021 3 Pipeline Overview

Unmatched Innovation Pipeline is Set to Drive Growth Total Pipeline Peak Sales Potential Up to €30bn2; ~50% Incremental

Corn S&T Other, Vegetables, Soybean S&T Herbicides Fungicides Insecticides Environmental Science Peak Sales Potential ~€10-11bn ~€4-5bn ~€3bn ~€3bn ~€2bn ~€5-6bn

New Hybrids New Varieties New Formulation New Formulation New Formulation Vegetable 150+ Commercialized 150+ Commercialized 35+ Launches in the next 20+ Launches in 20+ Launches in ~130 Hybrids/Varieties Commercialized Annually Annually Annually Decade the next Decade the next Decade

Ongoing New Formulation Launches Expected Expected in the next Decade

Refreshment 20+

Plenexos (Spidoxomat)3

2024 (Isoflucypram) Belt Smart –

Fox Supra (Indiflin®)1 Short Stature Corn Carbon Business Model 2021 Hybrids (Fluoxapiprolin)3

Short Stature Corn Soybean Herbicide New Non-Selective New Fungicide for Decis Phoenix 4th Generation Bollgard 1 Trait Trait Stack with Five- PPO Herbicide Asian Soybean Cotton Trait Rust

2030 Tolerances – Next Generation 3rd Gen. Soybean New Mode of Novel Mite Solution Dicamba-Tolerant Herbicide Tolerance Insect-Control Trait Action Herbicide Canola Trait Select Planned Product Launches Product Planned Select 2025 Traits

Note: Subject to regulatory approvals and pending registrations. Represents a subset of the pipeline. Launches are all approximate. .1 In collaboration with Sumitomo 2 Company estimate 3 Products not registered in all jurisdictions

8 /// Bayer Capital Markets Day /// The Beginning of What‘s Next /// March 10-11, 2021 next-generation biotech traits

35 4 Transformative Technologies

Scale and Expertise in Biotech Crop Development Lead the Industry Developing World-Class Biotech Traits and Crops

Trait Development Process (12-15 years)

Phase 0 Phase 1 Phase 2 Phase 3 Phase 4

Gene/Trait Identification Proof of Concept Early Development Advanced Development Pre-Launch Genomics and High-Throughput Gene Optimization and State- Large-Scale Transformation, Trait Integration, Regulatory Regulatory Submissions & Protein Screening to Identify of-the-Art Genome Editing Commercial Candidate Data Generation Approvals, Seed Bulk-Up, Desired Characteristics Capabilities Drive Product Selection, Pre- Regulatory System Testing and Concept Demonstrations In- Data Generation Pre-Marketing Crop

Competitive Advantage Competitive Advantage Competitive Advantage Competitive Advantage Competitive Advantage Knowledge of optimal New traits are introgressed Unrivaled global regulatory Industry-leading genomics Best-in-class genome editing and genome locations into the most elite germplasm, experience capabilities and germplasm libraries gene expression toolkits drive and stacked with the industry’s precision in gene to phenotype Largest global field-testing Identification of optimal Best-in-class screening capabilities leading traits optimization footprint diversifies geographic agronomic systems (trait, Ability to rapidly test many data insights germplasm, chemistry) for gene combinations to product deployment & customer evaluate stacks recommendations 10 /// Bayer Capital Markets Day /// The Beginning of What‘s Next /// March 10-11, 2021 4 Transformative Technologies

Next-Gen Soy Traits to Offer Greatest Weed Control Flexibility Technologies Provide Solutions to Address Farmer Needs, Herbicide Resistance Challenges

• Glyphosate • HPPD • Glyphosate • HPPD Fourth-Gen herbicide Fifth-Gen • Dicamba • 2,4-D herbicide • Dicamba • 2,4-D Phase 3 tolerances Phase 2 tolerances 5 • Glufosinate 6 • Glufosinate • PPO1

Enables continued use of conservation tillage and no- till systems Control Soybean HT4 Control Soybean HT5 which improve carbon sequestration 2020 Demo Plot in Monmouth, Illinois 2020 Demo Plot in Monmouth, Illinois and soil health (First treatment is dicamba and Enlist @ V3 (3X rate PPO herbicide @ V3 & R1) followed by Liberty and Callisto @ R1) 1 In collaboration with Sumitomo

11 /// Bayer Capital Markets Day /// The Beginning of What‘s Next /// March 10-11, 2021 4 Transformative Technologies

Third-Gen Intacta Further Enhances Insect Control Spectrum Intacta 2 Xtend launches in 2021; Next-Generation Currently in Phase 3

• Builds on the Intacta franchise technologies by 3rd Gen. 3rd Gen. 3rd Gen. delivering Soybean Soybean Soybean multiple Control Insect Control Control Insect Control Control Insect Control modes-of- action for insect Soybean Looper Infested Velvetbean Caterpillar Infested Southern Armyworm Infested control

• Phase 3

• Acre opportunity Reduces insecticide use 3rd Gen. 3rd Gen. 3rd Gen. focused on Brazil market and the Soybean Soybean Soybean environmental impact of the Control Insect Control Control Insect Control Control Insect Control crop protection Black Armyworm Infested South American Podworm Infested Sunflower Looper Infested program

1 Pending regulatory approvals Always read and follow label instructions. Products not registered in all jurisdictions.

12 /// Bayer Capital Markets Day /// The Beginning of What‘s Next /// March 10-11, 2021 4 Transformative Technologies

First Biotech Trait to Launch for Piercing and Sucking Insects NEW: USDA Deregulation of Trait Paves Way for 2021 U.S. Stewarded Ground Breakers Program

• Protein design and optimization resulted in a protein that controls targeted piercing/sucking insect pests through expression in the plant tissues they attack

• Built-in technology will help protect cotton and may help reduce insecticide applications for tarnished plant bugs and thrips species1, providing more management flexibility

Reduces insecticide use and the environmental impact of the crop protection program

1 ThryvOn™ Technology has proven protection against tobacco thrips (Frankliniellafusca); Western flower thrips Glendora, Mississippi, U.S.A. (Frankliniellaoccidentalis); tarnished plant bug (Lygus hesperus); and the Western Tarnished Plant bug (Lygus lineolaris). Scouting is critical to determine which and how many insecticide applications are recommended when economic thresholds are met Planting date May 13, 2020; Picture taken Nov. 4, 2020 13 /// Bayer Capital Markets Day /// The Beginning of What‘s Next /// March 10-11, 2021 4 Transformative Technologies

Next-Gen Insect Control Traits in Corn Launching Near-Term Below- and Above-Ground Insect Control Refresh with Broader Spectrum, Better Efficacy

Aug. 9, 2019 Demo Plot Root Dig in Waterloo, Iowa, U.S. 2018-2019 Season at V5-V6 in Sorriso, MT, Brazil

Root and leaf protection SmartStax® PRO ControlSeeds (Nonand Traits BtSafety) Brazil 4thSeeds Gen.and Traits LepSafety Brazil Non-CRW ensures Protection optimum use of fertilizers • ADVANCING TO LAUNCH: Recent China import approval • NEW: Recent full cultivation approval in Brazil and sunlight paves way for planned commercial launch in 2021-2022 for represents a critical milestone for planned for maximum yield potential. Corn Rootworm 3, i.e. SmartStax PRO and VTPRO4 commercial launch in 2025 • Includes novel RNAi MOA introduced through CRW3 • First 2 new MOA in Brazil for fall armyworm in more • Acre opportunity of >75m than a decade

14 /// Bayer Capital Markets Day /// The Beginning of What‘s Next /// March 10-11, 2021 4 Transformative Technologies

Game-Changing Short Stature Corn Shows Improved Standability High Wind Events in Bayer Field Trials Consistently Demonstrate a Reduction in Severity of Damage

Three Approaches to Short Stature Corn To Provide Market Access Flexibility • In this photograph from Iowa in summer 2020, Short Stature Corn plots (surrounded in red) are still standing, compared to wind Breeding: Phase 3 damaged taller corn that borders it. • Advanced breeding used to introgress naturally occurring short stature characteristic into elite germplasm Biotechnology: Phase 3 • In collaboration with BASF, uses transgene to shorten internodes; enables applicability across wide-array of germplasm Genome Editing: Discovery • Multiple, elegant approaches to generate short-stature corn, creating potential for opportunities in multiple markets

15 /// Bayer Capital Markets Day /// The Beginning of What‘s Next /// March 10-11, 2021 advanced breeding technologies

35 4 Transformative Technologies

Annual Germplasm Upgrade Drives Growth and Attracts Partners Global Germplasm Libraries and Advanced Breeding Tools Deliver High-Performing Seeds

Corn Soybeans Cotton Vegetables

• Deployed >200 new hybrids • Deployed >200 new varieties • Deployed >10 varieties in 2020; • Deploy ~130 varieties in 2020; offer >1,350 hybrids in 2020; offer >850 varieties in offer >25 varieties in the U.S. annually; focus in tomatoes globally the Americas • U.S. lint/acre yield advantage and peppers; sell over 21,000 vegetable hybrids and varieties • >7 bu/acre U.S.A. yield • Top volume XtendFlex with leading varieties; 2020 was in 22 crops annually advantage with leading Soybeans have a 4+ bu/ac 88 lbs./ac advantage for hybrids1 in like-for-like trait advantage vs. Enlist E3 in Deltapine vs. top-planted • Focus on disease resistance package hybrid comparisons germplasm trials2 competitor varieties and yield with new launches

Protect performance with seed-applied Provides for annual price mix gains as growers Digital Ag becomes proof point solutions trade up to higher-performing seeds for performance advantage

1 Bayer estimates – Annual yield advantage calculated each year by comparing 3 leading DEKALB products within each state having a minimum of 100 comparisons to national competitor products containing similar crop protection traits as of February 2021. All comparisons are head-to-head using +- 2RMs and weighted average calculated using 15% moisture. 2 Data as of October 22, 2020. 2020 Bayer Commercial Germplasm Trials (94 locations in 2020 reporting data located in IL, IN,IA, KS, MD, MI, MN, MO, NE, OH, SD, TN, and WI) Bayer Commercial Germplasm Trials = 9 of the top 10 volume forecasted XtendFlex products. 17 /// Bayer Capital Markets Day /// The Beginning of What‘s Next /// March 10-11, 2021 4 Transformative Technologies

Scale and Leading Technology Drives New Seed Development Optimizing Extensive Germplasm Library to Develop New Capabilities for Better Customer Solutions

8–10 Year Product Development Timeline

Grow Selections in New Generation of Vast Library of Every seed Prescribed Field Imaging at scale Germplasm genotyped Protected Culture Experiments Products

Includes hundreds of Proprietary chipping 7 acre, automated Time savings in the Collected >45 million Advanced analytics thousands of unique technology for DNA greenhouse in AZ will lab enables 2 years data points through applied to every sets of genetic genotyping preserves allow 3 planting cycles of germplasm/trait our field imaging decision. Partnership information. Represents seed for subsequent a year, speeding time to combination testing capabilities with Climate Corp. to breeding in 120+ protected culture and market in the field enable next-gen locations/25+ countries field testing product development

Competitive Competitive Competitive Competitive Competitive Competitive Advantage Advantage Advantage Advantage Advantage Advantage Allows us to precisely Pipelines for corn & Enabling faster Improving customer Data accuracy and AI driven, globally create new genetic soybean are 4X & 6X development of new recommendations, analytics throughout connected pipeline is lines needed every larger than 2012 due to products in a better match products the pipeline to unlocking new potential year from a genotyping in the lab protected greenhouse to specific enhance decision fueled by data and proprietary library saving 1 year of testing environment environments making at every stage insights 18 /// Bayer Capital Markets Day /// The Beginning of What‘s Next /// March 10-11, 2021 4 Transformative Technologies Precision Breeding: Moving from Selecting the Best with Breeding 3.0 to Designing the Best Seeds for Farmers Uses Advanced Genetic Models and Selection, Environmental Modeling and Predictive Analytics

Breeders working with new AI algorithms design germplasm combinations • Powered by customer needs and insights, our data scientists generate digital product concepts and Industry’s leading requirements global germplasm • Using our vast germplasm library and pool cutting-edge genomic selection model, AI models – supervised by scientists – design germplasm to meet concepts

• New breeding and selection methods and our automated greenhouse facilities quadruple the rate of product improvement • Prescriptive field testing operations evaluate

potential new products across diverse Sample of DNA growing environments/farming practices to from chipped seed advance best product concepts for is sequenced customers Automated greenhouse facilities advance selected seeds

19 /// Bayer Capital Markets Day /// The Beginning of What‘s Next /// March 10-11, 2021 4 Transformative Technologies

Gene Editing Targets With High Commercial Relevance Accelerating Nearly 200 Target Identified in Several Technically Challenging Focus Areas

Gene Editing Pipeline Targets Across Crops Collaboration with Pairwise Included • Corn crop productivity editing target results in Control short 87 stature corn Edited ~200 phenotype Targets

Controls Edited • Corn crop productivity editing target Crop productivity - Corn Crop productivity - soy results in Crop productivity - canola Crop productivity - wheat increased Disease - Corn Disease - Soybean kernel rows 16 16 20 24 Disease - Wheat

20 /// Bayer Capital Markets Day /// The Beginning of What‘s Next /// March 10-11, 2021 new approaches in crop protection

121 4 Transformative Technologies

Small Molecule Candidates in Discovery Phase Double Driven by Continued Strategic Enhancements to Identify and Optimize Candidates

Redefining Our Approach Supported by Data Science Approaches Drivers Biological Screening increased automation and Weed, Insect and data science > % Fungal Resistance New/unknown70 MoAs of all Phenotyping running Discovery projects Regulatory Pressure finds new starting points (all Indications). missed with conventional on Old Chemistries screening Increasing Regulatory > = Hurdles for New Products Target-based Screening direct focus on new Modes of Action Strong Reliance on x 2New Small Molecules a Few Modes of Action Early Safety Testing Candidates in Discovery drives optimization toward since 2015 registrable compounds

22 /// Bayer Capital Markets Day /// The Beginning of What‘s Next /// March 10-11, 2021 4 Transformative Technologies Well Positioned to Maintain Track Record of Success in Small Molecules Bayer Has Launched At Least One New Active Ingredient (AI) Per Year Since 2007

Industry Leading Performance in CP Development • Across all indications, the company has consistently – and significantly – outperformed all other players in Crop Protection • 15 new AIs launched since 2007; ~10 AI in the current development pipeline Early Safety Testing Focuses Efforts on Registrable Compounds • Increasing regulatory standards globally make it more challenging – and expensive – to bring CP innovation to market • However, Bayer expects to maintain high innovation output, increasing the proportion of novel MoA in the second half of the decade Industry Leading In-House Innovation Engine Supplemented by Strategic Technology Development Agreements • Development capability and capacity to enable key innovation from other ag companies to addresses critical key grower needs not covered by in-house innovation; doing consistently, with 6 co-developments from 2010-2025 • Highly trusted partner to smaller ag players, enabling them to bring their innovative solutions to a broader community of growers.

A Promising Project Pipeline: Active Ingredients in Development Phase of Pipeline (Phases 2-4)

Herbicides Fungicides Insecticides

• Novel PPO Herbicide1 Phase 3 • iblon Advancing to Launch • Plenexos Phase 3

• New Herbicide MOA Phase 3 1 • Fox Supra Phase 4 • Novel Mite Solution Phase 3

• Xivana Phase 4

1 In collaboration with Sumitomo • New Fungicide Phase 2 23 /// Bayer Capital Markets Day /// The Beginning of What‘s Next /// March 10-11, 2021 4 Transformative Technologies

Scale, Innovation Underpin Excellent Life Cycle Management Sustains Value Generation from Crop Protection Small Molecule Chemistry

Enablers of Unique Life Multi-Dimensional 8x Sales Cycle Management in Nematicide Nematicide

Approach to Small Molecule Application Fruits & Grapes & Crop Protection Lifecycle Management Plantations Soil Vegetables & Active Ingredient Stewardship Potatoes NEW!: Example: Fluopyram Expands to Eight Markets Across Two Application • Sustainable and consistent resistance Methods Driving 8X Sales in Eight Years; management Potential to Double in Next Decade Cereals • Responsible maximum soil loading guidelines Foliar Fungicide Application Fungicide Foliar

Rapeseed/Canola Grower Convenience

Vegetables & • Differentiated formulations for the Potatoes application methods • Ready mixture solutions for built-in resistance management and broader spectrum of activity Fruits & • Compatibility for tank mix and rotation Grapes in the program of treatment, especially with biologicals

2013 2014 2015 2016 2017 2018 2019 2020

24 /// Bayer Capital Markets Day /// The Beginning of What‘s Next /// March 10-11, 2021 4 Transformative Technologies

Plenexos: The Next Generation Ketoenol Insecticide First Launches Expected in 2024; > €300m Peak Sales Potential

NEW: First ketoenol insecticide expected to offer both foliar and soil uses

Plenexos will enhance ketoenol insecticides by offering: • High plant mobility, which ensures high efficacy against key sucking pests (aphids, white flies) at low dose rates for foliar and soil uses

• Will feature a broad crop scope, as the ketoenol Spidoxamat2 is suitable for application in arable and horticulture crops Spidoxamat - foliar Spidoxamat - soil (soybeans, cotton, fruits and vegetables) Increases • Regulatory submissions in key markets planned in 2022, productivity approvals expected starting in 2024 per acre through • Targeted markets: LATAM, NA, APAC and TAMECIS1 improved insect control Developed under the guidelines of Bayer’s new Sustainability Development Policy, to meet regulatory requirements of today and tomorrow Untreated Untreated

Always read and follow label instructions. Products not registered in all jurisdictions. 1 TAMECIS stands for Turkey, Africa, Middle East, Commonwealth of Independent States 2 Commercialization is dependent on multiple factors, including successful conclusion of the regulatory process. The information presented herein is provided for educational purposes only and is not and shall not be construed as an offer to sell, or a recommendation to use, any unregistered pesticide for any purpose whatsoever. It is a violation of federal law to promote or offer to sell an unregistered pesticide. 25 /// Bayer Capital Markets Day /// The Beginning of What‘s Next /// March 10-11, 2021 4 Transformative Technologies

New Herbicide Molecule Unlocks Greater Flexibility First New Mode of Action for Post Emergence Weed Control in 30 Years Advances to Phase 3

Potential to build on #1 position in global herbicides1

Enables continued use Glyphosate Glyphosate + Graminicide Mix Partner + New Herbicide of conservation Standard 1 Standard 2 Product concept with new active tillage and no- till systems which improve • NEW: Project advances to Phase 3, following Phase 2 advancement last year carbon sequestration • Allows use in various market segments, beyond traditional nonselective use and soil health • Opens new opportunities for herbicide tolerance trait systems in major crops; discovery program launched

1 Internal estimates

26 /// Bayer Capital Markets Day /// The Beginning of What‘s Next /// March 10-11, 2021 4 Transformative Technologies

Fox Supra Fungicide Upgrades Fox Franchise in Brazil New technology to control Asian Soybean Rust; >€500m Peak Sales Potential Opportunity

Builds on #1 position in soybean fungicides1

• Long-lasting solution to offer unrivaled control of Asian Soybean Rust, the most difficult to control and commercially most relevant disease for soybean growers in Brazil

• Indiflin®2, a new technology which is exceptionally strong in Asian Rust control, is an innovative AI that will be the new technological backbone of the Fox family

• Fox Supra combines the next-generation technology Indiflin®, Increases with Prothioconazole, another leading soy fungicide with a productivity through different mode of action, both helping to reduce the improved development of resistance and to broaden the spectrum of Asian Soybean efficacy to other relevant diseases Rust control

• The outstanding and long-lasting disease control provided by Standard (Fox) Fox Supra Fox Supra will enable growers to increase yield

1 Internal estimates 2 In collaboration with Sumitomo. Always read and follow label instructions. Products not registered in all jurisdictions

27 /// Bayer Capital Markets Day /// The Beginning of What‘s Next /// March 10-11, 2021 4 Transformative Technologies

Exploring New Product Concepts Drives Future Growth for Biologics Open Innovation approach broadens product offerings with exceptional product development and support

4-6 Year Product Development Timeline

Partner of choice for developing biological products including new concepts

Research Field Discovery Grower Support Industry leading Optimization Development portfolio

Vast library of diverse Core competencies in World wide network of Dedicated resources Sustaining today’s microbes for new fermentation and field testing capabilities to understand leading lineup and generation of microbials formulation optimization for early screening and compatibility, pioneering next and biochemicals of microbial products for development of spray rainfastness and generation of agriculture programs stability of biologicals biologicals in jug and on seed Competitive Competitive Competitive Competitive Competitive Advantage Advantage Advantage Advantage Advantage In depth understanding Market leading end Understanding of Exceptional customer Ability to address of genomes and use products with geographic product support with market untapped markets and modes of action results ease of handling for range with precise leading biological work within challenging in novel products customer and good guidance on practical products regulatory constraints shelf life for use worldwide distribution 28 /// Bayer Capital Markets Day /// The Beginning of What‘s Next /// March 10-11, 2021 4 Transformative Technologies ® Serenade : Delivering Biologic Growth in Expanding Markets Accelerated growth in emerging soil and expanding foliar bacterial markets across fruit & vegetable

NEW – Serenade Soil Activ propels growth of Serenade brands >€150M peak net sales in next 10 years

Serenade “lighthouse” brand and unique Bacillus amyloliquiefaciens strain QST 713 delivers sustainable solutions in emerging soil and expanding bacterial disease markets via Tailored Solutions

• Serenade ASO brand offers unique MOA components to 83% Increased biomass control foliar bacterial and fungal diseases, while reducing resistance risk and reducing residues Serenade ASO foliar Serenade Soil Activ • Serenade Soil Activ provides farmers handling efficiency with Sustainably increases low use rates and higher concentration of spores for fast root marketable colonization, generating increased marketable yields with yield with spores improved quality and nutrient density optimized for improved root • Serenade Soil Activ launching in the U.S. and Australia in colonization 2021, in Turkey in 2023 and broader global uses to follow Untreated • Targeted markets: NA, EMEA, APAC and LATAM Untreated Untreated

Always read and follow label instructions. Products not registered in all jurisdictions.

29 /// Bayer Capital Markets Day /// The Beginning of What‘s Next /// March 10-11, 2021 powered by data science

32 4 Transformative Technologies

Data is Digital Currency to Build a Global Integrated Platform Continuous Circle of Value Creation from Richer Data Sets, Leading to Smarter Digital Tools

Drive customer satisfaction Develop better seed and and loyalty, attract more data chemistry products

Gather and Organize Data Align R&D Testing to Reflect Farmer Practices

Visualize and Tabulate Digital Digitize the Pipeline R&D

Data Driven Algorithms for Compare and Benchmark Improved Discovery and Product Development

Advancement and Deployment Diagnose, recommend of new germplasm, traits, and and prescribe molecules

31 /// Bayer Capital Markets Day /// The Beginning of What‘s Next /// March 10-11, 2021 4 Transformative Technologies

Digital Insights Unlock Opportunity to Farm in New & Different Ways Quantitative Comparisons and Analysis Can Further Optimize Performance, Improve Ag Practices

EXAMPLE 1: Seed Advisor Models Improve Productivity Per Acre With Better Seed Placement Recommendations

• Models powered by >6.9m data points BAYER from >8,600 hybrids and >70,000 fields 213 bu/ac • 2017-2020 testing demonstrates 6 bu/ac yield lift using recommendations COMPETITOR “We recommend Bayer products • Product enhancements using FieldView 207 bu/ac that models show will data improve placement accuracy outperform competitor products in the market.”

EXAMPLE 2: Showing Growers the Value of Fungicide Applications Through Their Own Data

• Delaro Performance Showcase highlighted benefits of timely fungicide application with an untreated strip between two Delaro fungicide treated strips • Planting and Delaro application data captured in FieldView • Bayer data demonstrate that 74% of the time, farmers see a positive response from fungicide application

32 /// Bayer Capital Markets Day /// The Beginning of What‘s Next /// March 10-11, 2021 5 Key Takeaways

Key Takeaways Delivering World Class Innovation

1 Pursuing sustainable innovation to shape the future of agriculture

2 Delivering the leading R&D pipeline in scale, productivity and value

3 Leading the development of next-generation biotech traits

4 Optimizing large and diverse germplasm library with advanced breeding technologies

5 Advancing new approaches in small molecules and biologicals

6 Unlocking opportunities for new business models, powered by data science

33 /// Bayer Capital Markets Day /// The Beginning of What‘s Next /// March 10-11, 2021 March 2021 Pipeline Strategic Business Entity R&D Pipeline

/////////// 6 Appendix

Corn R&D Pipeline – Peak Sales Potential: €10-11bn

R&D Target Technology Phase* Enhancement**

Dig Br PBt 1 2 3 4 Dev. Subm. YIELD & ABIOTIC STRESS Annual germplasm upgrades Short Stature Corn Short Stature Corn 1

Seed Placement North America NEW

Seed Density North America2 EMEA LATAM

*R&D Phases: PEST MANAGEMENT 1 – Research, 2 – Early Development, 3 – Late Development, 4 – Registrations Filed Chewing Pests : (Life Cycle Management activities) Above Ground (Lepidoptera) **Product enhancement 4th generation Lepidoptera protection Dev. – Under development; Subm. – Submitted for Registration 5th generation Lepidoptera protection

Below Ground (Coleoptera) Br Breeding – incl. native traits and molecular breeding Corn Rootworm 3 (i.e. SmartStax PRO and VTPRO4) adv. to launch th 4 generation Coleoptera protection PBt Plant Biotech – biotechnology traits

DISEASE MANAGEMENT Dig Digital –models and algorithms that enable digital agricultural tools Plant Health Systems Corn Disease Shield - Annual upgrades Digital Disease Management North America Progress achieved Phases 1 through 4 WEED MANAGEMENT Status indication for Life Cycle Management Items Herbicide tolerance Strategic collaborations 4th generation weed management system Represents annual advancements and upgrades with RHS2 5th generation weed management system Pipeline status highlighting significant development, progress or advancement in R&D Pipeline (pink) and Key Life Cycle RHS2 = Second Generation Roundup Hybridization System 1 In collaboration with BASF 2 Ongoing upgrades to both commercialized and next-generation capabilities Management (blue) work.

35 /// Bayer Capital Markets Day /// The Beginning of What‘s Next /// March 10-11, 2021 6 Appendix

Soybean R&D Pipeline – Peak Sales Potential: €4-5bn

R&D Target Technology Phase* Enhancement**

Dig Br PBt 1 2 3 4 Dev. Subm. YIELD & ABIOTIC STRESS Annual germplasm upgrades High Yielding Soy1 Seed Placement North America

PEST MANAGEMENT Chewing Pests

Insect Protection *R&D Phases: 2nd generation insect protection adv. to launch 1 – Research, 2 – Early Development, 3 – Late Development, 4 – Registrations Filed 3rd generation insect protection **Product enhancement: (Life Cycle Management activities) Nematodes Dev. – Under development; Subm. – Submitted for Registration Plant health systems 2nd generation Soy Cyst Nematode resistance Br Breeding – incl. native traits and molecular breeding DISEASE MANAGEMENT PBt Plant Biotech – biotechnology traits Soy Native Resistance – Annual Upgrades

Digital Disease Management Dig Digital –models and algorithms that enable digital agricultural tools North America

WEED MANAGEMENT

Herbicide tolerance Progress achieved Phases 1 through 4 th 4 generation weed management Status indication for Life Cycle Management Items system Strategic collaborations 5th generation weed management Represents annual advancements and upgrades system Pipeline status highlighting significant development, progress or advancement in R&D Pipeline (pink) and Key Life Cycle 1 In collaboration with BASF Management (blue) work.

36 /// Bayer Capital Markets Day /// The Beginning of What‘s Next /// March 10-11, 2021 6 Appendix Other R&D Pipeline – Peak Sales Potential: ~€5-6bn

R&D Target Technology Phase* Enhancement** R&D Target Technology Phase* Enhancement**

Dig Br PBt CP 1 2 3 4 Dev. Subm. Dig Br PBt CP 1 2 3 4 Dev. Subm. YIELD & ABIOTIC STRESS YIELD & ABIOTIC STRESS Annual germplasm Annual germplasm upgrades upgrades WEED MANAGEMENT 4th Generation Herbicide Tolerance

DISEASE MANAGEMENT PEST MANAGEMENT Disease package annual Chewing Pests upgrade 4th Generation Bollgard Cereals Cotton Sucking Pests Digital disease mgmt (EMEA) NEW ThryvOn Technology adv. to launch (Lygus / Thrips cotton) YIELD & ABIOTIC STRESS

Annual germplasm YIELD & ABIOTIC STRESS upgrades (including podshatter) Annual germplasm upgrades

WEED MANAGEMENT Rice Annual hybrid production Dicamba-Tolerant Canola OSR Seed Treatment DISEASE MANAGEMENT Digital disease mgmt (NA) New Fungicidal Seed Treatment WEED MANAGEMENT

2nd gen weed management Acceleron - Annual upgrades 1 system Redigo FS 25 Early Pipeline Seed Growth Seed New Biological Sugarbeets

Br Breeding – incl. native traits and molecular breeding *R&D Phases: Progress achieved Phases 1 through 4 1 – Research, 2 – Early Development, 3 – Late Development, 4 – Registrations Filed Status indication for Life Cycle Management Items PBt Plant Biotech – biotechnology traits Strategic collaborations Crop Protection – chemical and biological solutions applied as Represents annual advancements and upgrades **Product enhancement: (Life Cycle Management activities) CP seed treatment, foliar or via soil Pipeline status highlighting significant development, progress Dev. – Under development; Subm. – Submitted for Registration or advancement in R&D Pipeline (pink) and Key Life Cycle Dig Digital –models and algorithms that enable digital agricultural tools Management (blue) work. 1 In collaboration with KWS

37 /// Bayer Capital Markets Day /// The Beginning of What‘s Next /// March 10-11, 2021 6 Appendix

Herbicides R&D Pipeline – Peak Sales Potential: ~€3bn

R&D Target Crop Phase* Enhancement**

Corn Soy Other F/V 1 2 3 4 Dev. Subm. New AI Development

Novel PPO Herbicide1 New Herbicide MOA NEW New Herbicide MOA NEW New Herbicide MOA NEW LCM Non-Selective

Improved Dicamba formulations Improved Dicamba & Glyphosate Premix adv. to launch Alion LCM

LCM Selective

Balance Flexx LCM NEW Merlin Flexx / Adengo LCM NEW New Soybean selective herbicide 3-way mixture New Soybean selective herbicide 2-way mixture Warrant LCM adv. to launch

Mateno Complete Pyrasulfotole LCM

Council Star Incelo adv. to launch Betanal LCM NEW Herbicide Formulation for UAV NEW Progress achieved Phases 1 through 4 Corn Corn *R&D Phases: Status indication for Life Cycle Management Items 1 – Research, 2 – Early Development, 3 – Late Development, 4 – Registrations Filed Strategic collaborations Soy Soybeans Represents annual advancements and upgrades **Product enhancement: (Life Cycle Management activities) Other Crops including cereals, oilseed rape, sugarbeets, cotton and rice Pipeline status highlighting significant development, progress Dev. – Under development; Subm. – Submitted for Registration or advancement in R&D Pipeline (pink) and Key Life Cycle

1 Management (blue) work. In collaboration with Sumitomo F/V Fruits and vegetables

38 /// Bayer Capital Markets Day /// The Beginning of What‘s Next /// March 10-11, 2021 6 Appendix

Insecticides R&D Pipeline – Peak Sales Potential: ~€2bn

R&D Target Technology Phase* Enhancement**

Corn Soy Other F/V 1 2 3 4 Dev. Subm. Chewing Pests

Belt Smart Sucking Pests Rice Planthopper Insecticide NEWNEW

New Biological Insecticide Plenexos Novel Mite Solution NEW

Chewing & Sucking Pests

Decis Phoenix NEW

Progress achieved Phases 1 through 4 *R&D Phases: Corn Corn Status indication for Life Cycle Management Items 1 – Research, 2 – Early Development, 3 – Late Development, 4 – Registrations Filed Strategic collaborations Soy Soybeans **Product enhancement: (Life Cycle Management activities) Represents annual advancements and upgrades Dev. – Under development; Subm. – Submitted for Registration Other Crops including cereals, oilseed rape, sugarbeets, cotton or rice Pipeline status highlighting significant development, progress or advancement in R&D Pipeline (pink) and Key Life Cycle Management (blue) work. F/V Fruits and vegetables

39 /// Bayer Capital Markets Day /// The Beginning of What‘s Next /// March 10-11, 2021 6 Appendix

Fungicides R&D Pipeline – Peak Sales Potential: ~€3bn

R&D Target Technology Phase* Enhancement**

Corn Soy Other F/V 1 2 3 4 Dev. Subm. Delaro Complete adv. to launch

Minuet / Serenade Soil Activ NEW Early Pipeline

New Biological Fungicide

New Fungicide NEW

Asian Soybean Rust Fox Supra (Indiflin®) New Fungicide

New AI Development

iblon adv. to launch Xivana NEW LCM Cayunis adv. to launch Delaro forte adv. to launch Prosaro Pro adv. to launch Super Nativo

40 /// Bayer Capital Markets Day /// The Beginning of What‘s Next /// March 10-11, 2021