Authors: Pallavi Subhraveti Ron Caspi Peter Midford Peter D Karp An online version of this diagram is available at BioCyc.org. Biosynthetic pathways are positioned in the left of the cytoplasm, degradative pathways on the right, and reactions not assigned to any pathway are in the far right of the cytoplasm. Transporters and membrane proteins are shown on the membrane. Ingrid Keseler Periplasmic (where appropriate) and extracellular reactions and proteins may also be shown. Pathways are colored according to their cellular function. Gcf_001463765Cyc: Aureimonas sp. AU4 Cellular Overview Connections between pathways are omitted for legibility. Anamika Kothari

lipid II (meso diaminopimelate containing)

FtsW HtpX MntH RS14400

lipid II (meso diaminopimelate containing)

Hormone Biosynthesis Polyprenyl Biosynthesis Polymeric Aldehyde Degradation glutaminyl-tRNA gln Aminoacyl-tRNA Charging Macromolecule Modification tRNA-uridine 2-thiolation Compound N 6 -(3-methylbut- a [protein]- 4-methyl-5-(2- a [protein]-L- L-rhamnulose a [protein]-L- biosynthesis via transamidation and selenation (bacteria) Degradation a sulfurated + an L-cysteinyl- indole-3-acetate di-trans,poly-cis methylglyoxal degradation I 2-en-1-yl)- adenosylcobinamide a purine 2-oxoglutarate NADPH NAD a [glutamine- phosphooxyethyl) glutamate-O 5 L-aspartate ATP HMP-PP 1-phosphate Cys ATP methionine Tetrapyrrole Biosynthesis [sulfur carrier] 37 synthetase]- [tRNA ] biosynthesis -undecaprenyl muropeptide adenosine ribonucleoside thiazole -methyl-ester biotin peptide- cys 5'-triphosphate L-tyrosine glu IV (bacteria) phosphate biosynthesis purine nucleotides degradation II (aerobic) Nucleoside and Nucleotide Degradation degradation methylglyoxal in tRNA methionine superpathway of pyrimidine Si-specific NAD(P)(+) bifunctional (indol-3-yl) (2E,6E)-farnesyl superpathway of heme b L-alanyl-γ-D- lactoylglutathione aspartyl/ (S)-S-oxide IPP superpathway of heme b siroheme biosynthesis cysteine deoxyribonucleosides degradation transhydrogenase: thiamine chemotaxis rhamnulose- aminoacyl-tRNA acetonitrile diphosphate biosynthesis from glutamate glutamyl-meso-2,6- lyase: tRNA (N6-isopentenyl bifunctional asparaginyl beta- bifunctional [glutamine biotin--[acetyl- reductase desulfurase: phosphate response hydrolase: biosynthesis from glycine AMP 2'-deoxycytidine diaminopimeloyl- adenosine(37)-C2)- adenosylcobinamide hydroxylase AUL35_RS17575 1-phosphate CoA-carboxylase] MsrA: msrA AUL35_RS13495 synthetase] synthase: regulator protein- AUL35_RS10920 uroporphyrinogen-III sufS D-alanine (R)-S- methylthiotransferase kinase/ domain-containing NAD(P)(+) aldolase/ (indol-3-yl) isoprenyl glu an [L-cysteine adenylyltransferase/ AUL35_RS18765 ligase: peptide- an L-glutamyl- gly uroporphyrinogen-III lactoylglutathione MiaB: miaB adenosylcobinamide- protein: glutamate short-chain aminoacyl-tRNA acetamide transferase: glutamate-- multifunctional 2',3'- nucleoside transhydrogenase [glutamine synthetase]- AUL35_RS14600 methionine gln [tRNA Gln ] C-methyltransferase: desulfurase]-S- phosphate AUL35_RS15240 thiamine methylesterase: dehydrogenase: hydrolase: AUL35_RS00400 tRNA ligase: 5-aminolevulinate cyclic-nucleotide 2'- deaminase: hydroxyacylglutathione succinate (Re/Si-specific): adenylyl-L-tyrosine (S)-S-oxide amidase: cobA sulfanyl-L-cysteine guanylyltransferase: phosphate cheB AUL35_RS04615 AUL35_RS05050 Asp-tRNA(Asn) AUL35_RS01900 synthase: hemA phosphodiesterase/ AUL35_RS16290 thymidine γ hydrolase: gloB dehydrogenase, aspartyl/ AUL35_RS08910 phosphorylase: reductase glutamate AUL35_RS07300 precorrin-1 L-alanyl- -D- cobU synthase: biotinyl-5'- /Glu-tRNA(Gln) di-trans,octa-cis 5-aminolevulinate [+ 3 isozymes] hydrophobic AUL35_RS08920 AUL35_RS15810 chemotaxis-specific synthase: glutamate-- 5'-nucleotidase/ thymidine glutamyl-meso- asparaginyl beta- AUL35_RS03450 adenylate MsrA: msrA amidotransferase: (indol-3-yl)acetate -undecaprenyl tRNA ligase: uroporphyrinogen-III 3'-nucleotidase: GMP IMP (R)-lactate membrane anchor adenosyl- hydroxylase protein-glutamate a protein-L- gltD gltB a [TusA sulfur- phosphorylase: diaminopimelate DHAP (S)-lactaldehyde a tRNA Cys gatB gatA gatC diphosphate AUL35_RS00350 porphobilinogen C-methyltransferase: AUL35_RS11190 2'-deoxyuridine protein: sdhD cobinamide domain-containing methyltransferase cys methionine- [+ 5 isozymes] an L-glutamyl- deoA + a [glutamine a 5-phosphooxy- undecaprenyl- synthase: hemB carrier protein]-S- phosphate a purine NADH NADP CheB: cheB (S)-S-oxide Glu cobA multifunctional 2',3'- IMP protein: synthetase]-O thiamine L-glutamyl- diphosphate [tRNA ] sulfanyl-L-cysteine N 6 -(3-methylbut- ribonucleoside ammonium adenosine cyclic-nucleotide 2'- dehydrogenase: thymine AUL35_RS20870 4 phosphate Gln 5'-deoxyadenosine an unsulfurated -(5'-adenylyl) [tRNA ] phosphatase: porphobilinogen precorrin-2 L-alanyl-D- 2-en-1-yl)-2- met 5'-diphosphate α phosphodiesterase/ guaB [sulfur carrier] -L-tyrosine a [protein]- - AUL35_RS11365 pyruvate (methylsulfanyl) MeOH adenosine 5'-nucleotidase/ glutamate a [protein]- L-glutamate Asp-tRNA(Asn) di-trans,octa-cis hydroxymethylbilane adenosine 37 a [TusD sulfur- deaminase: 3'-nucleotidase: XMP L-Ala-D/L-Glu 3-hydroxy- succinate /Glu-tRNA(Gln) -undecaprenyl (S)-4-amino-5- synthase: hemC in tRNA carrier protein]-S- add AUL35_RS11190 epimerase: L-aspartate amidotransferase: phosphate oxopentanoate 2-deoxy-α- sulfanyl-L-cysteine multifunctional 2',3'- uracil AUL35_RS01875 gatB gatA gatC preuroporphyrinogen sirohydrochlorin D-ribose 1- inosine guanosine cyclic-nucleotide 2'- L-alanyl-L- a peptidoglycan with a [glutamine a protein-L- phosphate ditrans,octacis- an [HPr]- phosphoenol ditrans,octacis- a mature an L-asparaginyl- queuosine at sirohydrochlorin phosphodiesterase/ glutamate γ chitin a cytidine 34 undecaprenyldiphospho- (L-alanyl- -D-glutamyl- undecaprenyldiphospho- peptidoglycan synthetase]-O Asn glu position 34 lys methionine- an L-glutaminyl- tRNA charging phosphopentomutase: L-histidine pyruvate (n) [tRNA ] ATP roseoflavin chelatase: a [TusE sulfur purine-nucleoside purine-nucleoside 5'-nucleotidase/ 4 Asp Ile2 Gln β L-lysyl-D-alanyl-D- in tRNA (R)-S-oxide [tRNA ] 5-aminolevulinate AUL35_RS17425 N-acetyl-(N-acetyl- -D- N-acetyl-(N- (meso-DAP -(5'-adenylyl) of a tRNA 5'-phosphate AUL35_RS08530 34 carrier protein]-S phosphorylase: phosphorylase: 3'-nucleotidase: peptide- a uridine in tRNA glucosaminyl)muramoyl- alanine) pentapeptide acetylglucosaminyl) containing) -L-tyrosine uroporphyrinogen-III -sulfanylcysteine AUL35_RS17395 AUL35_RS17395 AUL35_RS11190 2-deoxy-D-ribose phosphoenolpyruvate- beta-N- methionine glu glu porphobilinogen L-alanyl-γ-D-glutamyl-L- muramoyl-L-alanyl-γ- a tRNA siroheme -protein acetylhexosaminidase: aminoacyl-tRNA tRNA glutamyl- tRNA (R)-S-oxide synthase: hemB 5-phosphate lysyl-D-alanyl-D-alanine D-isoglutaminyl-N-(β- bifunctional uroporphyrinogen tRNA 2- glu lytic murein bifunctional [glutamine AUL35_RS03310 hydrolase: Q(34) synthetase lysidine(34) reductase hypoxanthine guanine xanthosine ala phosphotransferase: ptsP D-asparaginyl)-L-lysyl- riboflavin kinase/ a tRNA Ala ala tRNA asp asp ser a tRNA ser gly a tRNA Gly decarboxylase: thiouridine(34) transglycosylase: synthetase] AUL35_RS10920 GluQRS: synthetase MsrB: msrB elongator porphobilinogen deoxyribose- phosphoenolpyruvate- beta-N- Met glutamate-- Ile His Trp Leu Tyr Pro Arg Cys Thr Phe AUL35_RS12605 D-alanyl-D-alanine AUL35_RS16945 adenylyltransferase/ AUL35_RS16445 FAD synthetase: TilS: tilS Met met initiator tRNA met ile a tRNA his a tRNA trp a tRNA leu a tRNA tyr a tRNA pro a tRNA arg a tRNA cys a tRNA thr a tRNA phe a tRNA synthase phosphate monofunctional acetylhexosaminidase: aminoacyl-tRNA tRNA tRNA ligase: -protein AUL35_RS06710 peptide- Lys Val biosynthetic [+ 6 isozymes] [glutamine synthetase]- hydrolase: lys a tRNA val a tRNA hydroxymethylbilane coproporphyrinogen III MnmA: mnmA aldolase: phosphotransferase: ptsP nagZ methionine alanine- AUL35_RS01900 aspartate- serine- glycine-- asn tRNA Asn gln a tRNA Gln xanthine guanine purine-nucleoside heme a biosynthesis deoC peptidoglycan monofunctional adenylyl-L-tyrosine AUL35_RS05050 glutamyl- a lysidine 34 synthase: hemC dehydrogenase: deaminase: phosphorylase: roseoflavin (R)-S-oxide methionine-- methionine-- -tRNA glutamate-- -tRNA isoleucine-- histidine-- tryptophan- leucine-- tyrosine-- proline-- arginine-- -tRNA cysteine-- threonine- tRNA ligase: phenylalanine-- 34 transglycosylase: phosphorylase: Ile2 oxygen-dependent a 2-thiouridine guaD AUL35_RS17395 biosynthetic a mature GlcNAc-1,6- N-acetyl-D- queuosine at in tRNA reductase tRNA ligase: tRNA ligase: lysine--tRNA ligase: ligase: tRNA ligase: ligase: tRNA ligase: tRNA ligase: -tRNA tRNA ligase: tRNA ligase: tRNA ligase: valine--tRNA ligase: tRNA ligase: ligase: tRNA ligase: -tRNA AUL35_RS01565 tRNA ligase: pheS xdhA xdhB an [HPr protein]- AUL35_RS15810 chitin adenine preuroporphyrinogen coproporphyrinogen in tRNA D-glyceraldehyde mtgA π pyruvate peptidoglycan peptidoglycan anhMurNAc- glucosamine position 34 protoheme N -phospho- (n) dinucleotide MsrB: msrB AUL35_RS00175 AUL35_RS00175 AUL35_RS01005 alaS AUL35_RS00350 aspS AUL35_RS06700 AUL35_RS06760 ligase: trpS AUL35_RS12690 AUL35_RS14360 AUL35_RS14585 AUL35_RS16680 AUL35_RS16710 serS AUL35_RS17870 ligase: thrS AUL35_RS01575 AUL35_RS03400 acetaldehyde transglycosylase: γ Asn of a tRNA Asp a [protein]-L- oxidase: hemF protoheme IX tRNA uridine-5- 3-phosphate L-histidine (meso-DAP L-Ala- -D-Glu- asn tRNA carboxymethylaminomethyl(34) xanthine a peptidoglycan with di-trans,octa-cis mtgA containing) DAP-D-Ala a [glutamine- methionine an L-methionyl- farnesyltransferase: an L-methionyl- an L-lysyl- an L-alanyl- an L-glutamyl- an L-aspartyl- an L-isoleucyl- an L-histidyl- an L-tryptophanyl- an L-leucyl- an L-tyrosyl- an L-prolyl- an L-valyl- an L-arginyl- an L-seryl- an L-cysteinyl- an L-threonyl- an L-phenylalanyl- an L-asparaginyl- an L-glutaminyl- protoporphyrinogen IX synthesis GTPase MnmE: mnmE (L-alanyl-γ-D-glutamyl- -undecaprenyl synthetase]- [elongator a glycyl-[tRNA Gly ] AUL35_RS01425 xanthine thymine degradation ADP [initiator tRNA Met ] [tRNA Lys ] [tRNA Ala ] [tRNA Glu ] [tRNA asp ] [tRNA Ile ] [tRNA His ] [tRNA Trp ] [tRNA Leu ] [tRNA Tyr ] [tRNA Pro ] [tRNA Val ] [tRNA Arg ] [tRNA ser ] [tRNA Cys ] [tRNA Thr ] [tRNA Phe ] [tRNA Asn ] [tRNA Gln ] L-lysyl-D-alanyl-D- diphosphate L-tyrosine tRNA Met ] protoporphyrinogen ferroheme o tRNA uridine-5- dehydrogenase a peptidoglycan di-trans,octa-cis uroporphyrinogen-III alanine) pentapeptide oxidase HemJ: hemJ carboxymethylaminomethyl(34) accessory protein thymine acetyl-CoA superpathway of purine deoxyribonucleosides degradation dimer (E. faeciums) -undecaprenyl uroporphyrinogen heme A synthase: synthesis enzyme MnmG: mnmG XdhC: xdhC diphosphate AUL35_RS00685 decarboxylase: protoporphyrin IX a 5-carboxymethylaminomethyl- [+ 2 isozymes] AUL35_RS12605 34 5,6-dihydrothymine 2'-deoxyguanosine β 2-thiouridine in tRNA a mature peptidoglycan sn-glycerol a CDP- ditrans,octacis- N-acetyl- -D- a [protein]-L- an [amino-group deferrochelatase/ ferroheme i urate a 3-oxoacid succinyl-CoA oleoyl-CoA H O NADH Nucleoside and Nucleotide Biosynthesis dihydropyrimidinase: (meso-diaminopimelate undecaprenyldiphospho- glucosaminyl-(1 a tRNA precursor β 2 carrier protein]- coproporphyrinogen III peroxidase 2'-deoxyadenosine 3-phosphate diacylglycerol -isoaspartate ATP hydA containing) N-acetyl-(N- -> 4)-N-acetyl- protein-L- C-terminal-γ- EfeB: efeB heme A synthase: β isoaspartate O- Fatty Acid and Lipid Biosynthesis superpathway of pyrimidine oxygen-dependent AUL35_RS00685 dihydropyrimidinase: purine-nucleoside acetylglucosaminyl) -D-muramate adenylate/guanylate (L-glutamate 5- inosine-5'-phosphate biosynthesis I 5-aminoimidazole ribonucleotide biosynthesis I ferrochelatase: a 5-aminomethyl-2- 3-oxoacid CoA- methyltransferase: tol-pal system- NAD(+) superpathway of guanosine superpathway of adenine salvage pyrimidine deoxyribonucleotide coproporphyrinogen hydA phosphorylase: lytic murein CDP-diacylglycerol-- muramoyl-L-alanyl- ribonuclease D: cyclase domain- semialdehyde-2-N-acetyl- ribonucleotides de novo biosynthesis AUL35_RS16925 thiouridine 34 in tRNA adenosine transferase associated diphosphatase: nucleotides de novo biosynthesis I adenosine nucleotides phosphorylation oxidase: hemF hydroxyferroheme i transglycosylase: glycerol-3-phosphate 3- γ-D-isoglutaminyl- AUL35_RS16665 containing protein: yl)-L-glutamategamma- palmitate biosynthesis (type II fatty acid synthase) UTP and CTP dephosphorylation I 3-(carbamoylamino)- deaminase: AUL35_RS17395 subunit A: beta-N- AUL35_RS12335 acyl-CoA nudC octanoyl-[acyl-carrier de novo biosynthesis I PRPP purine-nucleoside AUL35_RS16945 phosphatidyltransferase: N-(β-D-asparaginyl) protein-L- AUL35_RS07965 glutamyl- gondoate biosynthesis gln AIR dTMP dCMP protoheme 2-methylpropanoate add AUL35_RS05840 acetylhexosaminidase: ribonuclease thioesterase: protein] biosynthesis hydrogencarbonate 5-(carboxyamino)imidazole adenine protoporphyrinogen IX phosphorylase: pgsA -L-lysyl-D-alanine isoaspartate(D- phosphate (anaerobic) IMP dTMP kinase: (d)CMP kinase: UTP [+ 6 isozymes] AUL35_RS03310 D: rnd adenylate/guanylate ybgC reduced β- an [amino-group (mitochondria, yeast) ribonucleotide synthase: amidophosphoribosyltransferase: AUL35_RS17395 purine-nucleoside 3-oxoacid CoA- aspartate) O- reductase: an acetoacetyl-[acp] IMP asp AUL35_RS00165 AUL35_RS12365 a 5-methylaminomethyl- beta-N- cyclase domain- nicotinamide D- carrier protein]- protoporphyrinogen phosphorylase: transferase: AMP argC a malonyl-[acp] an oleoyl-[acp] AUL35_RS18750 AUL35_RS02470 dTDP dCDP 2-thiouridine 34 in tRNA CTP synthase: nucleoside CMP 1-(3-sn- methyltransferase: containing protein: an acetoacetyl-[acp] glutamine- IMP oxidase HemJ: hemJ ferroheme a 2'-deoxyinosine a mature peptidoglycan a mature peptidoglycan monofunctional AUL35_RS20340 acetylhexosaminidase: ribonucleotide C-terminal-γ- 3-oxoacyl-[acyl- N5-CAIR 5-phospho-β- adenine deaminase: AUL35_RS00300 triphosphate AUL35_RS17395 phosphatidyl) a nucleoside 5'- AUL35_RS16750 AUL35_RS05535 3-oxoacyl-[acyl- hydrolyzing dehydrogenase: gly nucleoside- nucleoside- (R)-3-amino-2- with (L-alanyl-γ-D- strand (non- biosynthetic nagZ a tRNA a protein L-β- oleate (5-phospho- carrier-protein] adenylosuccinate D-ribosylamine AUL35_RS11725 hydrolase: 2-deoxy-α-D- -sn-glycerol monophosphate cyclic-AMP carrier-protein] carbamoyl- guaB diphosphate diphosphate protoporphyrin IX methylpropanoate glutamyl-meso-2,6- reducing terminus) peptidoglycan isoaspartate L-glutamyl)- reductase: fabG beta-ketoacyl-ACP synthase: 5-(carboxyamino)imidazole adenine deaminase: CTP AUL35_RS13905 ribose 1-phosphate 3-phosphate a 2,3,4-saturated reductase: fabG phosphate kinase: kinase: a 5-methylaminomethyl- diaminopimeloyl-D- transglycosylase: succinate N-acetyl-D- α-methyl ester L-glutamate a (3R)-3- synthase I: fabB AUL35_RS04010 ribonucleotide mutase: purE phosphoribosylamine- AUL35_RS00585 deferrochelatase/ 3-oxoacyl-CoA GlcNAc synthase: XMP AMP AUL35_RS02335 AUL35_RS02335 2-(S-geranyl) nucleoside phosphopentomutase: alanine) tetrapeptide mtgA muramate a (3R)-3-hydroxybutanoyl-[acp] hydroxybutanoyl-[acp] beta-ketoacyl-ACP -glycine ligase: purD peroxidase Storage Compound Biosynthesis UDP carA carB CAIR thiouridine 34 in tRNA triphosphate AUL35_RS17425 dTTP dCTP EfeB: efeB 3-hydroxyacyl- synthase II: fabF di-trans,octa-cis 3-hydroxyacyl- glutamine- adenylo-succinate hydrolase: 2-deoxy-D-ribose a peptidoglycan ACP dehydratase phosphoribosylaminoimidazolesuccinocarboxamide hypoxanthine ferrochelatase: polyhydroxybutanoate biosynthesis -undecaprenyl ACP dehydratase carbamoyl asp hydrolyzing GMP GAR AUL35_RS13905 5-phosphate dimer (E. faecium FabZ: fabZ adenylosuccinate synthase: AUL35_RS09525 AUL35_RS16925 diphosphate FabZ: fabZ phosphate synthase: guaA a 5-methylaminomethyl- UMP , tetrapeptide) an (11Z)-3-oxo-icos-11-enoyl-[acp] lyase: phosphoribosylglycinamide xanthine CDP 3-hydroxyacyl-[acyl- 3-hydroxyacyl- protoheme acetyl-CoA 2-(Se-phospho) deoxyribose- AUL35_RS09555 SAICAR formyltransferase: phosphoribosyltransferase: adenine and multifunctional 2',3'- carrier-protein] [acyl-carrier- 3-oxoacyl-[acyl- aspartate GMP 34 a ring-opened 7- lipid II (meso AUL35_RS02280 adenosine selenouridine in tRNA phosphate ditrans,octacis- (indol-3- a nucleoside sn-glycerol a peptide with a supercoiled protein] AUL35_RS00610 acetyl-CoA C- cyclic-nucleotide 2'- purine ribonucleosides degradation methylguanine an N-modified coenzyme A dehydratase carrier-protein] carbamoyltransferase adenylosuccinate aldolase: dGTP undecaprenyldiphospho- diaminopimelate yl)pyruvate RNA an N-terminal duplex DNA dehydratase AMP hypoxanthine salvage VI acetyltransferase: phosphodiesterase/ aminoacyl-[tRNA] GTP triphosphate 3-phosphate FabA: fabA reductase: fabG catalytic subunit: FGAR CMP deoC in DNA N-acetyl-(N- containing) glycerol-3- L-alanine DNA FabA: fabA guanylate kinase: lyase: AUL35_RS09555 phosphoribosyltransferase: hpt AUL35_RS00975 5'-nucleotidase/ AUL35_RS14495 acetylglucosaminyl) adenylate/guanylate phosphate helicase a (3R,11Z)-3-hydroxy- AUL35_RS02395 adenosine [+ 2 isozymes] a 5-methylaminomethyl- multifunctional 2',3'- 3'-nucleotidase: indolepyruvate a (2E)-but-2-enoyl-[acp] AICAR phosphoribosylformylglycinamidine 34 D-glyceraldehyde adenosine muramoyl-L-alanyl-γ-D- cyclase domain- DNA- RecQ: a (2E)-but-2-enoyl-[acp] icos-11-enoyl-[acp] adenylate kinase: 2-selenouridine cyclic-nucleotide 2'- AUL35_RS11190 acetaldehyde bifunctional DNA- monofunctional aminoacyl-tRNA ferredoxin dehydrogenase: aminopeptidase synthase: purL purQ purS IMP adenosine kinase: 3-phosphate deoxyguanosinetriphosphate isoglutaminyl-L-lysyl- containing protein: directed RNA recQ N-carbamoyl- AUL35_RS16580 acetoacetyl-CoA in tRNA phosphodiesterase/ formamidopyrimidine biosynthetic hydrolase: oxidoreductase AUL35_RS18250 N: pepN enoyl-ACP 3-hydroxyacyl-[acyl- GDP bifunctional AUL35_RS06885 uridine adenosine triphosphohydrolase: (glycyl) -D-alanyl-D-alanine AUL35_RS07965 polymerase: acyl-CoA/acyl-ACP L-aspartate 5'-nucleotidase/ glycosylase/ 5 peptidoglycan AUL35_RS10920 glycerol-3- ATP- reductase FabI: fabI carrier-protein] phosphoribosylaminoimidazolecarboxamide FGAM guanine and guanosine salvage II AUL35_RS16705 subunit alpha: AMP acetoacetyl- 3'-nucleotidase: deaminase: DNA-(apurinic transglycosylase: aminoacyl-tRNA adenylate/guanylate rpoC rpoB phosphate dependent dehydrogenase: dehydratase dihydroorotase: ADP formyltransferase/IMP cyclohydrolase: purH AUL35_RS20905 enoyl-ACP Amine and Polyamine Biosynthesis CoA add or apyrimidinic mtgA cyclase domain- [+ 2 isozymes] DNA AUL35_RS05265 FabA: fabA AUL35_RS15610 phosphoribosylformylglycinamidine AUL35_RS11190 pyrimidine deoxyribonucleotides monofunctional hydrolase: dehydrogenase: reductase FabI: fabI nucleoside- vitamin B12- reductase: tRNA processing acetyl-CoA ala a peptide helicase [+ 2 isozymes] FAICAR cyclo-ligase: AUL35_RS02275 dephosphorylation site) lyase: mutM biosynthetic AUL35_RS05050 containing protein: AUL35_RS09405 3-hydroxyacyl- dihydroorotase: diphosphate dependent vitamin B12- guanosine phbB cytidine xanthosine adenosine inosine guanosine triphosphate (indol-3 yl) putrescine nucleoside triphosphate 2'-deoxyguanosine peptidoglycan lipid II (meso di-trans,octa-cis AUL35_RS05535 DHAP RecG: recG a butanoyl-[acp] ACP dehydratase AUL35_RS14500 kinase: ribonucleotide dependent bifunctional putrescine homospermidine homospermidine (3R)-3- acetyl-CoA RNA a single a butanoyl-[acp] AIR biosynthesis I a polycistronic pyrophosphohydrolase: a [DNA]- 2,6-diamino-4- transglycosylase: diaminopimelate -undecaprenyl cyclic-GMP FabZ: fabZ AUL35_RS02335 reductase: ribonucleotide phosphoribosylaminoimidazolecarboxamide biosynthesis III biosynthesis II biosynthesis I hydroxybutanoyl- poly-[(R)-3- a 5'-phospho- 4-oxo-2-pentenal an N-modified an uncharged stranded DNA beta-ketoacyl-ACP (S)-dihydroorotate tRNA precursor mazG nucleotide- hydroxy-5-(N-methyl) mtgA containing) diphosphate AUL35_RS00615 reductase: formyltransferase/IMP cyclohydrolase: purH CoA hydroxybutanoate] [DNA] tRNA beta-ketoacyl- arg dCTP dCMP purine-nucleoside purine-nucleoside purine-nucleoside purine-nucleoside 3'-phosphate formamidopyrimidine amino acid synthase II: fabF a (2E,11Z)-icosa-2,11-dienoyl-[acp] AUL35_RS00615 guanine arg putrescine putrescine pseudouridine ACP synthase quinone-dependent adenosine phosphorylase: phosphorylase: phosphorylase: phosphorylase: di-trans,octa-cis beta-ketoacyl-ACP homospermidine homospermidine class I poly(R)- degradation a peptidoglycan II: fabF dihydroorotate GTP IMP dUTP diphosphatase: nucleotides AUL35_RS17395 AUL35_RS17395 AUL35_RS17395 AUL35_RS17395 -undecaprenyl synthase I: fabB enoyl-ACP dADP xanthine synthase: synthase: hydroxyalkanoic dimer (S. aureus) beta-ketoacyl- dGDP reductase FabI: fabI dehydrogenase: pyrimidine deoxyribonucleotides de novo biosynthesis I phosphoribosyltransferase: agmatine AUL35_RS16910 AUL35_RS16910 acid synthase: a tRNA precursor a tRNA precursor pseudouridine AUL35_RS17065 degradation III diphosphate ACP synthase sym- sym- α-D-ribose- a 3-oxohexanoyl-[acp] enoyl-ACP AUL35_RS10650 AUL35_RS00610 L-ornithine phaC with a 5' with a 5' pseudouridine nucleoside triphosphate I: fabB PRPP nucleoside- nucleoside- adenine and adenosine salvage III agmatinase: homospermidine homospermidine 1-phosphate reductase FabI: fabI orotate UDP CTP extension and extension and a kinase: pyrophosphohydrolase: AMP a 7,8-dihydro- a reduced 3-benzyl-3,6 - (2S)- 3-oxoacyl-[acyl- diphosphate hypoxanthine phosphoenol N-β-aspartyl- diphosphate vitamin B12-dependent nucleoside triphosphate speB ornithine a long 3' trailer short 3' extension AUL35_RS01780 mazG phosphopentomutase: ubiquinone-6 acetoacetate succinyl-CoA H O stearoyl-CoA H O γ-L-glutamyl- an L-cysteinyl- a 3-oxohexanoyl-[acp] kinase: phosphoribosyltransferase: hpt poly-[(R)-3- AMP nucleosidase: 8-oxoguanine electron-transfer bis(cysteinylglycine) 2 methylsuccinyl- 2 L-arginine gly Pro carrier-protein] a gondoyl-[acp] kinase: agmatinase: decarboxylase: pseudouridine dUTP dUMP AUL35_RS17425 GTP acetyl-CoA dGDP pyruvate [tRNA ] orotate AUL35_RS02335 ribonucleotide reductase: hydrolase: AUL35_RS13905 hydroxybutanoate] in DNA flavoprotein - 6-(hydroxymethyl) CoA D-alanine reductase: fabG AUL35_RS02335 adenine CDP speB AUL35_RS03525 5'-phosphate AUL35_RS15760 3-oxoacyl-[acyl- phosphoribosyltransferase: AUL35_RS00615 GMP ribonuclease P D-ribose 5- -diketopiperazine purine-nucleoside dUDP adenine 3-oxoacid CoA- tol-pal system- isoaspartyl carrier-protein] AUL35_RS15660 dATP vitamin B12-dependent putrescine putrescine ribonuclease D: protein component: pseudouridine- phosphate electron transfer glutathione a (3R)-3-hydroxyhexanoyl-[acp] dGTP phosphorylase: 5-hydroxy-CTP 5-hydroxy-CMP bifunctional DNA- ribosome 3-oxoadipyl- associated Cys- ribonucleotide reductase: ribonuclease AUL35_RS10365 5'-phosphate flavoprotein- transferase: peptidase/L- reductase: fabG AUL35_RS17395 nucleoside-diphosphate AUL35_RS12335 formamidopyrimidine membrane CoA pyruvate synthase: tRNA(Pro) AUL35_RS00615 D: rnd ubiquinone AUL35_RS20340 biogenesis acyl-CoA asparaginase: 3-hydroxyacyl- a (3R)-3- orotidine 5'- adenosine kinase: AUL35_RS02335 ribonuclease glycosidase: glycosylase/ dipeptidase: thiolase: kinase: pyk gshB deacylase: biotin-carboxyl carrier ribonuclease D: a tRNA precursor oxidoreductase: 3-oxoacid CoA- GTPase Der: thioesterase: AUL35_RS15540 ACP dehydratase hydroxyhexanoyl-[acp] phosphate dUTP dCDP D: rnd ribonuclease PH: AUL35_RS01785 DNA-(apurinic AUL35_RS05185 pcaF ybaK protein assembly AUL35_RS12335 with a short AUL35_RS15775 transferase AUL35_RS01665 ybgC FabZ: fabZ adenosine AUL35_RS08655 uracil or apyrimidinic 3-hydroxyacyl- orotidine-5'- dUTP diphosphatase: nucleoside-diphosphate 3' extension subunit A: [+ 5 isozymes] 3-hydroxyacyl-[acyl- a [biotin carboxyl- deaminase: site) lyase: mutM 3-benzyl-3,6 - norophthalmate ACP dehydratase phosphate guanine and guanosine salvage AUL35_RS17065 kinase: AUL35_RS02335 an oxidized AUL35_RS05840 4-methyl-3- pyruvate arg asp carrier-protein] carrier protein]-L-lysine superpathway of pyrimidine add H + ubiquinol-6 bis(cysteinyl)- 6- gly dGTP stearate cys a tRNA Pro FabZ: fabZ decarboxylase: nucleoside triphosphate electron-transfer H + oxoadipyl-CoA dehydratase biotin--[acetyl- nucleobases salvage dCTP a tRNA (hydroxymethyl) phosphate 3-hydroxyacyl- pyrF pyrophosphohydrolase: ribonuclease D: a [DNA]- a 5'-phospho- 7,8-dihydro- flavoprotein GDP FabA: fabA CoA-carboxylase] inosine precursor with ribonuclease PH: AUL35_RS12335 nucleotide- 4-oxo-2-pentenal -diketopiperazine [acyl-carrier- uracil guanosine mazG xanthine and Carbohydrate Degradation [DNA] 8-oxoguanine acetoacetyl-CoA succinate ligase: UMP a 5' extension AUL35_RS08655 ribonuclease Entner-Doudoroff pathway I 3'-phosphate protein] uracil purine-nucleoside xanthosine salvage D-galactosamine and N- heparin degradation a (2E)-hex-2-enoyl-[acp] AUL35_RS14600 UMP kinase: purine-nucleoside dUMP D: rnd dehydratase phosphoribosyltransferase: phosphorylase: D-glucopyranose acetyl-D-galactosamine a [biotin carboxyl- AUL35_RS00410 phosphorylase: CMP ribonuclease P FabA: fabA AUL35_RS17415 AUL35_RS17395 thymidylate synthase: degradation heparin an N-acetyl-β- DNA with adenine:7,8- an insertion enoyl-ACP carrier protein]-N phosphorylation protein component: 6-phosphate + phosphoenol UMP AUL35_RS17395 AUL35_RS00905 N-acetyl-D- 34 acetoacetate menadione NADH H a RNA-DNA hybrid lauroyl-CoA H O (S)-NADHX sec 6 guanine xanthosine heparinase: a 5,10-gly a uridine D-hexosaminide dihydro-8- 2 sequence ser a tRNA reductase FabI: fabI -biotinyl-L-lysine UDP AUL35_RS10365 glucose-6- dADP pyruvate a (2E)-hex-2-enoyl-[acp] CMP galactosamine AUL35_RS12785 methylenetetrahydrofolate in tRNA oxoguanine mismatch element IS30 NAD(P)H-hydrate enoyl-ACP nucleoside- UMP kinase: hypoxanthine dTMP purine-nucleoside protein S-nitrosylation phosphate 4-deoxy-2-O-sulfo- DDE-type xanthine (d)CMP kinase: 6-phosphate dehydratase: reductase FabI: fabI AUL35_RS00410 phosphorylase: dehydrogenase: β beta-N- integrase/ acyl-CoA/acyl-ACP diphosphate dTMP kinase: AUL35_RS12365 and denitrosylation N-acetylglucosamine- -L-erythro-hex-4- acetoacetate--CoA NADH-quinone ribonuclease tol-pal system- AUL35_RS08590 phosphoribosyltransferase: AUL35_RS17395 Metabolic Regulator Biosynthesis zwf tRNA uridine-5- acetylhexosaminidase: A/G-specific transposase/ serine- dehydrogenase: a [biotin carboxyl- kinase: UDP xanthine AUL35_RS00165 CDP xanthine 6-phosphate enopyranuronosyl-(1,4)-D-N ligase: AUL35_RS15055 oxidoreductase: nuoN HI: rnhA associated a hexanoyl-[acp] AUL35_RS00610 a [protein]- carboxymethylaminomethyl(34) adenine recombinase: NAD(P)H-hydrate -tRNA AUL35_RS05265 carrier-protein dimer]- AUL35_RS02335 phosphoribosyltransferase: 6-phospho deacetylase: nagA -sulfoglucosamine 6-O-sulfate acetoacetate--CoA AUL35_RS14610 nuoK AUL35_RS03310 ribonuclease HII: pyruvate acyl-CoA gln nucleoside-diphosphate hypoxanthine dTDP nucleoside- L-cysteine glycosylase: dehydratase: 6 xanthine ppGpp metabolism D-glucono- synthesis GTPase MnmE: mnmE kinase: pyk AUL35_RS06085 ligase: [+ 2 isozymes] N -biotinyl-L-lysine kinase: AUL35_RS02335 AUL35_RS00610 trehalose biosynthesis I ligase: AUL35_RS08125 AUL35_RS14625 nuoI beta-N- AUL35_RS01630 thioesterase: beta-ketoacyl-ACP UTP phosphoribosyltransferase: hpt nucleoside-diphosphate diphosphate phosphoribosyltransferase: trehalose biosynthesis V trehalose biosynthesis IV 1,5-lactone D-galactosamine mutY AUL35_RS14280 serS acetyl-CoA acetyl-CoA hypoxanthine an uncharged tRNA uridine-5- nuoH AUL35_RS14640 acetylhexosaminidase: ybgC an insertion[+ 5 isozymes] synthase II: fabF UTP kinase: AUL35_RS02335 kinase: 6-phosphate NADH carboxylase AUL35_RS00610 D-glucopyranose tRNA 6-phosphogluconolactonase: β carboxymethylaminomethyl(34) nuoE AUL35_RS14655 nagZ sequence IS30 a hexanoyl-[acp] carboxylase CTP synthase: phosphoribosyltransferase: hpt AUL35_RS02335 pppGpp α 4-deoxy- -L-erythro-hex-4- beta-ketoacyl-ACP GMP a glycogen UDP-α-D-glucose -maltose a [protein] 3- pgl synthesis enzyme MnmG: mnmG acetoacetyl-CoA AUL35_RS14660 DNA a nucleoside 5'- pyruvate carboxyltransferase biotin AUL35_RS00300 CTP synthase: dTTP 6-phosphate enopyranuronosyl-(1,4)-D-N diphosphate an apurinic site with integrated an L-seryl- synthase I: fabB beta-ketoacyl- AUL35_RS00300 CTP glycogen debranching maltose alpha-D- nitrosothio- AMP monophosphate dATP laurate subunit beta: carboxylase IMP XMP D-gluconate -sulfoglucosamine 6-O-sulfate an N-acetyl-β- adenine within DNA transposon [tRNA sec ] ACP synthase protein GlgX: glgX glucosyltransferase: treS L-alanine D-tagatofuranose an alcohol a 3-oxooctanoyl-[acp] AUL35_RS11000 subunit: accC CTP CTP bifunctional (p)ppGpp trehalose-6- 6-phosphate a 5-carboxymethylaminomethyluridine 34 D-hexosamine maltose alpha-D- a 7,8-dihydrofolate + II: fabF a [carboxyl-carrier synthetase/guanosine- glycogen debranching phosphate 6-phosphate NAD menadiol glucosyltransferase: treS phosphogluconate in tRNA protein dimer]-N 6 - protein GlgX: glgX 3-oxoacyl-[acyl- beta-ketoacyl- 3',5'-bis(diphosphate) 3'- synthase: α,α-trehalose dehydratase: a maltodextrin carrier-protein] ACP synthase carboxybiotinyl-L-lysine pyrophosphohydrolase: AUL35_RS08795 AUL35_RS15275 glycogen degradation II N,6-O-disulfo-D-glucosamine I: fabB AUL35_RS15665 a [protein]- (1S,2R)-1- a [protein chain an N-terminal- a 5'-phospho- (E)-4-hydroxy-3- reductase: fabG malto-oligosyltrehalose S-nitrosoglutathione D-tagatofuranose a purine base a lipid II a peptidoglycan a [DNA]-3'- an acyl-CoA H O a [protein]- α,α-trehalose glycine betaine L-cysteine glu a (6S)-5- ser C-(indol-3- (R)-β-lysine elongation factor L-methionyl-L- 2 methylbut-2-en- synthase: treY KDGP 1,6-bisphosphate a glycogen lesion in DNA hydroxyl [DNA] L-tyrosine dGDP a (3R)-3-hydroxyoctanoyl-[acp] a 3-oxooctanoyl-[acp] 6-phosphate biosynthesis I (Gram- S-(hydroxymethyl) formyltetrahydrofolate yl)glycerol EF-P]-L-lysine 34 threonyl-[protein] 1-yl diphosphate polysaccharide flavodoxin- vitamin B12- GTP ppGpp negative bacteria) Aromatic Compound glutathione glycogen/starch/ 3-phosphate biosynthesis a maltooligosyl-trehalose trehalose- tagatose- bifunctional DNA- monofunctional cisplatin damage tol-pal system- dependent dependent 3-hydroxyacyl- 3-oxoacyl-[acyl- peptidoglycan biosynthesis I Cell Structure Biosynthesis Biosynthesis dehydrogenase/ 2-dehydro-3-deoxy- D-galactose degradation I (Leloir pathway) alpha-glucan N-sulfo-D-glucosamine tyrosine lipid IV biosynthesis (P. putida) Kdo transfer to phosphatase: choline bisphosphate formamidopyrimidine biosynthetic bifunctional EF-P lysine type I methionyl response ATP- associated (E)-4-hydroxy- ribonucleotide ACP dehydratase carrier-protein] (meso-diaminopimelate containing) A lipid IV biosynthesis (E. coli) cellulose class III alcohol phosphogluconate phosphorylase: tryptophan autokinase: A lipid IV I (E. coli) malto-oligosyltrehalose otsB choline β peptidoglycan folylpolyglutamate aminoacylase aminopeptidase: 3-methylbut- FabZ: fabZ reductase: fabG A nucleoside- bifunctional (p)ppGpp chorismate biosynthesis I -D- aldolase: glycosylase/ synthase: dependent acyl-CoA reductase: UDP-N-acetyl- a (3R)-3- biosynthesis trehalohydrolase: treZ dehydrogenase: dehydrogenase: aldolase: glgP transglycosylase: synthase/ GenX: genX map 2-enyl- a [protein]-AUL35_RS20095 a (3R)-3- diphosphate synthetase/guanosine- α,α-trehalose galactopyranose AUL35_RS14835 DNA-(apurinic AUL35_RS11005 DNA ligase: thioesterase: AUL35_RS00615 3-hydroxyacyl-[acyl- a (3R)-3- α-D-glucosamine hydroxydecanoyl- UDP-N-acetyl- CMP-Kdo lipid IV (E. coli) betA AUL35_RS14035 AUL35_RS08800 mtgA dihydrofolate diphosphate L-tyrosine hydroxytetradecanoyl- UDP-N-acetyl- A cellulose kinase: 3',5'-bis(diphosphate) 3'- α,α-trehalose D-erythrose aldose 1- an α-limit dextrin or apyrimidinic trpB AUL35_RS10665 ybgC GDP carrier-protein] hydroxyoctanoyl-[acp] UDP-N-acetylglucosamine [acp] α-D-glucosamine betaine aldehyde D-tagatose- synthase: synthase: ispG phosphate [acp] α AUL35_RS02335 4-phosphate S-(hydroxysulfenamide) epimerase: D-glucosamine site) lyase: mutM [a protein chain an N-terminal L- 2-C-methyl-D- dehydratase 1-carboxyvinyltransferase: -D-glucosamine UDP- pyrophosphohydrolase: 3-deoxy-7- D-glyceraldehyde bisphosphate 3-hydroxyacyl- 3-deoxy-D-manno- glutathione pyruvate 4-alpha- di-trans,octa-cis AUL35_RS10995 D-glyceraldehyde elongation factor met threonyl-[protein] erythritol-2,4- acyl-ACP--UDP-N- forming AUL35_RS15665 betaine-aldehyde 3-phosphate AUL35_RS07165 aldolase, a peptidoglycan FabA: fabA ACP dehydratase murA phosphoheptulonate glucanotransferase: -undecaprenyl EF-P]-N-(β-L- [DNA] a carboxylate cyclodiphosphate acetylglucosamine O- acyl-ACP--UDP-N- octulosonic acid cellulose dehydrogenase: galactose class II, non- a [DNA]- 3-phosphate trp FabZ: fabZ UDP-N-acetyl-α- synthase class II: type I malQ a 5'-phospho- a modified diphosphate lysyl)-L-lysine 34 acetylglucosamine O- transferase: synthase betB mutarotase: catalytic subunit: nucleotide- 4-oxo-2-pentenal a (6S)-5- a (2E)-oct-2-enoyl-[acp] D-glucosamine- acyltransferase: lpxA 3-deoxy- AUL35_RS01925 glyceraldehyde- a debranched [DNA] nucleobase 3-hydroxyacyl- acyltransferase: lpxA AUL35_RS06625 catalytic GDP AUL35_RS10440 AUL35_RS03090 L-arabinose 3'-phosphate formyltetrahydrofolate enolpyruvate glycine betaine D-arabino- 3-phosphate α-limit dextrin [acyl-carrier- UDP-3-O-[(3R)-3- subunit: hydroxylamine α degradation I enoyl-ACP UDP-3-O-[(3R)-3- α-Kdo-(2->6)- heptulosonate dehydrogenase: -D- protein] fatty acid elongation -- saturated UDP-N- hydroxydecanoyl]- bcsA reductase FabI: fabI hydroxymyristoyl]-N- lipid IV (E. coli) 7-phosphate gap galactopyranose D-glyceraldehyde glycogen/starch/ a 1-acyl-2- 2,3-bis-O- a peptide with (3R,5S)-3- acetylmuramate α A DHAP L-arabinopyranose a single a [DNA]-3'- + a 5'-phospho- (S)-1-pyrroline- dehydratase N-acetyl- -D- cellulose 3-phosphate NAD F6P acetyl-CoA propanoyl-CoA palmitoyl-CoA H O enoyl-ACP acetyl-α-D-glucosamine alpha-glucan arachidonoyl- (geranylgeranyl) 2 an N-terminal hydroxy-1- FabA: fabA dehydrogenase: glucosamine 3-dehydroquinate stranded DNA hydroxyl [DNA] 5-carboxylate dADP reductase FabI: fabI UDP-3-O-acyl-N- 13-DPG phosphorylase: bifunctional an acetoacetyl-[acp] murB UDP-3-O-acyl-N- synthase: D-glucopyranose sn-glycerol -sn-glycerol L-methionine pyrroline-5- acetylglucosamine ammonium glgP CTP CTP proline vitamin B12- a (2E)-oct-2-enoyl-[acp] ala UDP-N-acetyl- acetylglucosamine α-Kdo-(2->4)- AUL35_RS16200 α-D-galactose L-ribulose 3-phosphate 1-phosphate carboxylatepyrroline-5- an octanoyl-[acp] deacetylase: phosphoglycerate UDP-α-D-glucose exodeoxyribonuclease NAD- fructose-6- acetyl-CoA C- tol-pal system- dehydrogenase/L- dependent α-D-muramate deacetylase: α-Kdo-(2->6)- 1-phosphate type I methionyl carboxylate AUL35_RS03685 3-dehydroquinate kinase: pgk α-D- VII large subunit: dependent phosphate acetyltransferase: associated glutamate gamma- ribonucleotide beta-ketoacyl-ACP acyl-CoA/acyl-ACP AUL35_RS03685 lipid IV (E. coli) ribulokinase: phosphatidate CDP-archaeol aminopeptidase: reductase: UDP-3-O-(3- A glucopyranose AUL35_RS06840 DNA ligase aldolase: fsa AUL35_RS08135 acyl-CoA reductase: dehydrogenase: UDP-N- glu UDP-3-O-(3- 3-phospho- glucokinase: AUL35_RS02795 cytidylyltransferase: synthase: semialdehyde map AUL35_RS06355 synthase II: fabF hydroxymyristoyl) type II 3- 1-phosphate exodeoxyribonuclease LigA: ligA fructose-6- [+ 2 isozymes] thioesterase: AUL35_RS00615 AUL35_RS05265 acetylmuramate-- hydroxydecanoyl) D-glycerate AUL35_RS03415 L-ribulose 5- AUL35_RS00395 AUL35_RS01135 dehydrogenase Hyp beta-ketoacyl-ACP -α-D-glucosamine dehydroquinate queuosine biosynthesis I (de novo) VII small subunit: phosphate ybgC [+ 2 isozymes] a 3-oxoacyl-[acp] L-alanine ligase: glutamate -α-D-glucosamine phosphate PutA: putA ADP synthase I: fabB UDP-3-O-(3- dehydratase: aroQ 2,3-bisphosphoglycerate- UDP- alpha-D-glucose AUL35_RS03650 racemase: UDP-3-O-(3- AUL35_RS01490 aldolase: fsa hydroxymyristoyl) dependent phosphate-specific [DNA] NMN a CDP-1-acyl- 3-oxopentanoyl- glu met a peptide an octanoyl-[acp] AUL35_RS09455 3-dehydroshikimate preQ glucose 4- unsaturated a 3-oxodecanoyl-[acp] hydroxymyristoyl) 0 phosphoglycerate AMP 2-arachidonoyl- CoA UDP-N-acetyl- glucosamine N- NADPH-dependent 7- epimerase D-xylose phosphoglucomutase: CDP-archaeol palmitate 3-oxoacyl- glucosamine N- mutase: a single-stranded D-glyceraldehyde glycerol α-D-muramoyl- D-glt acyltransferase: shikimate cyano-7-deazaguanine GalE: galE degradation I AUL35_RS06595 D-xylulose a ribonucleoside dihydroxyacetone 3-oxoacyl-[acyl- [acyl-carrier- acyltransferase: AUL35_RS03430 oligodeoxyribonucleotide 3-phosphate beta-ketoacyl- L-alanine lpxD dehydrogenase: reductase QueF: queF 5-phosphate 5'-monophosphate carrier-protein] lpxD ACP synthase protein] UDP-2-N,3-O-bis[(3R)- AUL35_RS12595 preQ 2-phospho- D-xylose UDP-2-N-[(3R)-3- 1 β reductase: fabG I: fabB reductase: 3-hydroxytetradecanoyl]- xylose (1,4)- -D-xylan UDP-N- hydroxydodecanoyl]- D-glycerate fabG α shikimate D-glucopyranose degradation a 5,10- a 2-thiouridine 34 32 an [L-cysteine a carboxy- a [ThiI sulfur- a peptide with a mismatched an N-terminal- D-ribulose beta-ketoacyl- acetylmuramoyl- -D-glucosamine tRNA guanosine(34) phosphopyruvate α-D- isomerase: a cytosine L-threo-3- acetyl-CoA a (3R)-3-hydroxydecanoyl-[acp] 3-O-[(3R)-3- UDP-α-D- desulfurase]-S- adenylated- cys carrier protein]- cys an N-terminal L-methionyl-L- 1-phosphate salicyl-CoA L-alanine--D- UDP-2,3- transglycosylase Tgt: tgt glucopyranose xylA 6-phosphate methylenetetrahydrofolate in tRNA in tRNA phenylserine DNA base pair ACP synthase hydroxydecanoyl]- hydratase: galactose D-mannose degradation a (1->4)-β-D-xylan DNA mismatch alanyl-[protein] a 2,3,4-saturated a (3R)-3-hydroxyacyl- shikimate kinase: 1-phosphate D-xylulose sulfanyl-L-cysteine [ThiS sulfur- L-cysteine L-proline bifunctional acetyl-CoA II: fabF 3-hydroxyacyl- glutamate ligase: α-D-glucosamine diacylglucosamine a 7-aminomethyl-7- AUL35_RS00290 3-hydroxyacyl- fatty acyl-[acp] [acyl-carrier protein] AUL35_RS16195 1,4-beta-xylanase: carrier protein] repair salicylyl-CoA carboxylase AUL35_RS03625 diphosphatase: 34 ACP dehydratase [acyl-carrier- deazaguanosine in tRNA phosphoenol xylulokinase: D-mannopyranose AUL35_RS15310 tRNA uridine-5- tRNA 2- protein MutS: L-fuculose- 5-hydroxylase/ biotin UDP-2,3- AUL35_RS01885 alpha-D-glucose a (1->4)-β-D-xylan cysteine low specificity L- type I methionyl FabZ: fabZ protein] shikimate 3- pyruvate 6-phosphate carboxymethylaminomethyl(34) prolyl phosphate diacylglucosamine tRNA preQ1(34) S- phosphate-specific xylB mannose-1-phosphate thiocytidine(32) cysteine desulfurase: threonine aldolase: AUL35_RS12535 aminopeptidase: oxidoreductase: carboxylase dehydratase meso- UDP-N-acetyl- UDP-2,3- phosphate oligosaccharide synthesis GTPase MnmE: mnmE aminopeptidase: pip aldolase: 3-hydroxyacyl-[acyl- α diphosphatase: adenosylmethionine pyruvate phosphoglucomutase: D-xylulose guanylyltransferase/ synthetase desulfurase: sufS AUL35_RS16980 DNA map AUL35_RS20890 subunit: accC FabA: fabA diaminopimelate -D-muramoyl-L- diacylglucosamine 3-phosphoshikimate 1- AUL35_RS08090 carrier-protein] AUL35_RS01885 ribosyltransferase- kinase: pyk AUL35_RS06595 5-phosphate mannose-6- tRNA uridine-5- TtcA: ttcA sufS mismatch gentisyl-CoA [+ 3 isozymes] alanyl-D-glutamate diphosphatase 3-hydroxyacyl- peptidoglycan maturation (meso-diaminopimelate containing) carboxyvinyltransferase: isomerase QueA: queA phosphate isomerase: carboxymethylaminomethyl(34) repair protein dehydratase UDP-2,3- D-glucopyranose a [ThiI sulfur- an N-terminal L- malonyl-CoA LpxI: lpxI aroA melibiose degradation synthesis enzyme MnmG: mnmG 32 an [L-cysteine FabA: fabA ACP UDP-N- diacylglucosamine pyruvate AUL35_RS16840 β-D-xylopyranose a 2-thiocytosine benzaldehyde a peptide pro MutS: mutS glycolaldehyde 5-enolpyruvoyl- an epoxyqueuosine 34 in tRNA 6-phosphate a thiocarboxylated- ala carrier protein]- gly met alanyl-[protein] DHAP dehydratase lipid II (meso F6P in tRNA desulfurase]- a properly matched acetylmuramoyl- diphosphatase lipid X shikimate 3- ala [ThiS sulfur- S-sulfanyl- a (2E)-dec-2-enoyl-[acp] FabZ: fabZ diaminopimelate containing) melibiose L-cysteine AMP DNA base pair enoyl-ACP L-alanyl-D- LpxI: lpxI phosphate tRNA a 5-aminomethyl-2- carrier protein] L-cysteine lipid-A-disaccharide monofunctional a 7,8-dihydrofolate 34 a 2,3,4-saturated reductase a trans-2-enoyl- glutamate--2, 6- chorismate epoxyqueuosine(34) thiouridine in tRNA enoyl-ACP lipid X (P. putida) synthase: biosynthetic fatty acyl-[acp] FabI: fabI [acyl-carrier protein] diaminopimelate synthase: reductase QueG: queG alpha-glucosidase/alpha- reductase FabI: fabI AUL35_RS00360 peptidoglycan ligase: galactosidase: melA [+ 2 isozymes] lipid-A-disaccharide aroC 34 MoO - N,N',N''- sn-glycero-3- an N-terminal- enoyl-ACP AUL35_RS03610 D-ala lipid A disaccharide transglycosylase: a queuosine in tRNA 3-methyl-2- 5,10-methylene- 2 4-hydroxy- synthase: molybdopterin triacetylchitotriose phospho-N- L-allo-threonine asp O-ureido-L- L-methionyl-L- glu ala digallate a protein reductase FabI: fabI (E. coli) mtgA chorismate oxobutanoate tetrahydromethanopterin cys L-threonine AUL35_RS00360 D-galactopyranose D-glucopyranose cofactor (arachidonoyl) homoserine seryl-[protein] tannase/feruloyl enoyl-ACP UDP-N-acetyl- D-alanine--D- tetraacyldisaccharide a nascent peptidoglycan ATP- a decanoyl-[acyl-carrier protein] lipid A ethanolamine esterase family reductase α-D-muramoyl- alanine ligase: 4'-kinase: with (L-alanyl-γ-D-glutamyl- 3-methyl-2-oxobutanoate beta-N- dependent disaccharide low specificity L- argininosuccinate low specificity L- type I methionyl glutamate-- alpha/beta FabI: fabI L-alanyl-γ-D- AUL35_RS03665 AUL35_RS06620 meso-2,6-diaminopimeloyl-D- Fatty Acid and Lipid Degradation hydroxymethyltransferase: molybdenum acetylhexosaminidase: protease beta-ketoacyl-ACP CDP-diacylglycerol (P. putida) lipoprotein posttranslational modification glycerophosphodiester threonine aldolase: synthase: threonine aldolase: aminopeptidase: cysteine ligase: hydrolase: glutamyl-meso-2,6- alanyl-D-alanine) pentapeptide AUL35_RS07715 cofactor sulfurase: nagZ subunit synthase II: fabF biosynthesis II enoyl-ACP D-alanyl-D-alanine tetraacyldisaccharide lipid IV (E. coli) AUL35_RS07900 A β AUL35_RS03500 phosphodiesterase: AUL35_RS16980 AUL35_RS18575 AUL35_RS16980 map AUL35_RS06815 HslV: hslV reductase diaminopimelate 4'-kinase: a [prolipoprotein]- oleate -oxidation 3-methyl-2-oxobutanoate beta-N- beta-ketoacyl-ACP penicillin-binding fatty acid β-oxidation I (generic) AUL35_RS00435 gallate DHAP FabI: fabI AUL35_RS06620 L-cysteine hydroxymethyltransferase: acetylhexosaminidase: a peptide synthase I: fabB UDP-N- protein 2: Mo(O)(S)- AUL35_RS03310 an N-terminal γ-L-glutamyl- lipid IV prolipoprotein oleate a (3Z)-alk-3- panB acetaldehyde canavaninosuccinate glycolaldehyde acetylmuramoylalanyl- A a nascent peptidoglycan AUL35_RS03605 a mature peptidoglycan with molybdopterin ala gly gly met L-seryl-[protein] D-alanine a 3-oxododecanoyl-[acp] (P. putida) diacylglyceryl enoyl-CoA sn-glycerol D-glutamyl-2, 6- with (L-alanyl-γ-D-glutamyl- (L-alanyl-γ-D-glutamyl-meso- long-chain-fatty- cofactor anandamide sn-glycerol a nascent peptidoglycan transferase: N,N'- N-acetyl-D- 3-phosphate diaminopimelate--D- meso-2,6-diaminopimeloyl- 2,6-diaminopimeloyl-D-alanyl- acid--CoA ligase: 3-oxoacyl-[acyl- 3-phosphate with D,D cross-links (meso- AUL35_RS06370 2-dehydropantoate THMPT diacetylchitobiose glucosamine alanyl-D-alanine ligase: D-alanine) tetrapeptide D-alanine) pentapeptide AUL35_RS01290 carrier-protein] glycerol-3- phosphatidylserine and diaminopimelate containing) a [prolipoprotein]- reductase: fabG phosphatidylethanolamine AUL35_RS03615 S-1,2-diacyl-sn- a (2E)-2- phosphate 1-O- L,D-transpeptidase: L,D-transpeptidase: oleoyl-CoA biosynthesis I glyceryl-L-cysteine enoyl-CoA di-trans,octa-cis a [bis(guanylyl an N-terminal- 6-O-trans- a (1->4)- acyltransferase α 37 UDP-N-acetyl- AUL35_RS08870 AUL35_RS08870 cob(II)inamide UDP- -D-glucose an adenosine a peptide with a γ-L-glutamyl-(S)- a (3R)-3-hydroxydodecanoyl-[acp] PlsY: plsY acyl-CoA -undecaprenyl molybdopterin) cofactor cys DMAPP gly 3',5'-ADP L-methionyl-L- met methoxy-mycolyl- α-D-glucan a CDP-diacylglycerol α-D-muramoyl- [+ 4 isozymes] a nascent peptidoglycan with [+ 4 isozymes] a mature peptidoglycan a mature peptidoglycan a 2,3,4-saturated acyl-CoA ATP in tRNA leader sequence a 1-acyl-sn signal peptidase II: dehydrogenase: phosphate chaperone]-L-cysteine 2-aminobutanoate 3'(2'),5'-bisphosphate valyl-[protein] trehalose 6- 1,4-alpha- phosphatidylcholine/ γ (L-alanyl-γ-D-glutamyl-meso- with (L-alanyl-γ-D-glutamyl- with D,D cross-links (meso- fatty acid dehydrogenase: a 2,3,4- bifunctional 3-hydroxyacyl- -glycerol 3- L-alanyl- -D- AUL35_RS10840 AUL35_RS00970 long-chain-fatty- phosphate glucan phosphatidylserine a nascent peptidoglycan 2,6-diaminopimelate) tripeptide a nascent peptidoglycan meso-2,6-diaminopimeloyl- AUL35_RS01520 saturated (3R)-3- nucleotidase CysQ: glutamate N- trehalose- ACP dehydratase glutamyl-meso-2,6- di-trans,octa-cis diaminopimelate containing) acid--CoA ligase: tRNA (adenosine(37)-N6) branching phosphate with L,D cross links (meso- with (L-alanyl-γ-D-glutamyl- D-alanine) tetrapeptide [+ 3 isozymes] a 2,3,4- cob(I)yrinic acid a,c-diamide undecaprenyl- signal glutathione AUL35_RS06640 type I methionyl acetyltransferase/ phosphatase: FabZ: fabZ synthase: diaminopimeloyl- -undecaprenyl an (S-diacyl-sn- a lipoprotein AUL35_RS01290[+ 3 isozymes] hydroxyacyl-CoA cysteine protein 1-acyl-sn-glycerol- diaminopimelate containing) meso-2,6-diaminopimeloyl- a 2,3,4-saturated adenosyltransferase: cobO phosphate glucose -dimethylallyltransferase peptidase synthase: aminopeptidase: AUL35_RS19085 D-alanyl-D-alanine phosphate glyceryl)-L-cysteinyl- (2E,9Z)- saturated (3S)-3- desulfurase: 3'(2'),5'-bisphosphate amino-acid trehalose-otsB GlgB: glgB 3-hydroxyacyl-[acyl- 3-phosphate glycine) tetrapeptide signal peptide fatty acyl CoA phosphotransferase: MiaA: miaA I: lepB gshB map CDP-diacylglycerol--serine [apolipoprotein] octadecenoyl-CoA hydroxyacyl-CoA cob(I)yrinic acid a,c-diamide sufS nucleotidase acetyltransferase a (1,6)-α-D- carrier-protein] acyltransferase: a mature peptidoglycan with signal peptide AUL35_RS00705 trans-methoxy- phospho-N- γ adenosyltransferase: CysQ: cysQ ArgJ: argJ glucosyl-(1,4) O-phosphatidyltransferase: (L-alanyl- -D-glutamyl-meso- apolipoprotein N- C1 Compound Utilization and Assimilation 6 mono-mycolate dehydratase AUL35_RS16325 peptidase AUL35_RS16420 a [bis(guanylyl N -(3-methylbut- N-acetyl-L- α pssA acetylmuramoyl- a mature peptidoglycan 2,6-diaminopimelate) tripeptide acyltransferase: lnt an N-terminal - -glucan FabA: fabA 1-acyl-sn-glycerol- a 3-sn-phosphatidyl- gluconeogenesis I Carbohydrate Biosynthesis α SppA: sppA α molybdopterin) 2-en-1-yl)- ophthalmate AMP methionine pentapeptide- with L,D cross-links (meso- a mature peptidoglycan O-antigen building blocks biosynthesis (E. coli) UDP- -D-glucose an N-acyl-(S-diacyl- coenzyme A -D-glucopyranosyl- UMP ala a leader sequence a peptide met L-valyl-[protein] 3-phosphate L-serine (S)-3-hydroxy-(9Z) formaldehyde oxidation cofactor chaperone]- adenosine 37 transferase: diaminopimelate containing) with (L-alanyl-γ-D-glutamyl- biosynthesis sn-glyceryl)-L- formaldehyde oxidation formate adenosylcobinamide diphosphoundecaprenol a (2E)-dodec-2-enoyl-[acp] UDP-α-D- α-D- a peptide -octadecenoyl-CoA a 2,3,4-saturated a 2,3,4-saturated VII (THF pathway) formate assimilation into 5,10- in tRNA acyltransferase: phosphatidylserine AUL35_RS03620 meso-2,6-diaminopimeloyl- (S)-malate D-glucopyranose 3-ketoacyl- II (glutathione-dependent) oxidation to CO triphosphate S-sulfanyl-L-cysteine D-glucopyranose cysteinyl-[lipoprotein] fatty acyl CoA 3-oxoacyl-CoA methylenetetrahydrofolate 2 AUL35_RS10770 decarboxylase: glycine) tetrapeptide galactose glucopyranose 6-phosphate CoA thiolase: enoyl-ACP a 1,2-diacyl- UDP- glucose-6- 6-phosphate formaldehyde AUL35_RS02490 1-phosphate alpha-D-glucose AUL35_RS00975 reductase FabI: fabI sn-glycerol undecaprenyldiphospho- malate galactopyranose glucose-1-phosphate phosphate formaldehyde formate formate an L-1- N-acetylmuramoyl-L- thymidylyltransferase phosphate-specific formate-- formate a 2'- an unstable enoyl-ACP 3-phosphate dehydrogenase: mutase: glf isomerase: 3-oxo-(9Z)- N-methyl-L- phosphatidylethanolamine alanyl-γ-D-glutamyl-meso UDP-Galf RfbA: rfbA phosphoglucomutase: dehydrogenase cob(II)alamin 3-methylbutanoate deoxyribonucleoside RNA dihydroxyacetone carbonic acid RecA filament- reductase FabI: fabI phosphatidate AUL35_RS10575 dTDP-α-D-glucose AUL35_RS06575 5-oxo-L-proline metabolism octadecenoyl-CoA a 5,10- tetrahydrofolate ATP ATP [DNA] a PII protein AUL35_RS06595 S-(hydroxymethyl) a tRNA precursor tryptophan GTP DNA complex -2,6-diaminopimeloyl- α F6P α-D-glucopyranose 3-ketoacyl- methylenetetrahydrofolate ligase: subunit alpha: 5'-triphosphate UTP dihydroxyacetone cytidylyltransferase: glycogen biosynthesis III (from -maltose 1-phosphate) glutathione CTP DNA a dodecanoyl-[acp] D-alanyl-D-alanine dTDP- 1-phosphate a [protein] with a [protein] with AUL35_RS04895 AUL35_RS01040 kinase: dhaL diguanylate AUL35_RS00395 CoA thiolase: bifunctional an N 10 - acetate- carbonic repair undecaprenyldiphospho- oxaloacetate glucose 4,6- glutamine-- an N-terminal an N-terminal acetyl-CoA glutathione- CO ribonuclease PH: AUL35_RS11840 cyclase: a CDP- D-glucopyranose UTP--glucose- AUL35_RS08135 methylenetetrahydrofolate 2 cob(I)yrinic acid a,c-diamide -CoA DNA [protein-PII] N-methyl-L- anhydrase: protein muramoylpentapeptide beta-N- ADP-α-D-glucose dehydratase: fructose-6- L-glutamine L-glutamate dependent formyltetrahydrofolate CCA tRNA AUL35_RS08655 dhaL diacylglycerol pyruvate 6-phosphate 1-phosphate 3-ketoacyl- dehydrogenase/ adenosyltransferase: ligase: acs polymerase III: uridylyltransferase: tryptophan AUL35_RS12825 AUL35_RS18035 RecO: beta-ketoacyl-ACP acetylglucosaminyltransferase: rfbB phosphate formaldehyde bifunctional nucleotidyltransferase: (Kdo) -lipid A phosphoenolpyruvate uridylyltransferase CoA thiolase: methenyltetrahydrofolate AUL35_RS16420 AUL35_RS03705 AUL35_RS10810 dihydroxyacetone oxidase: solA [+ 5 isozymes] a stabilizedrecO 2 murG methylenetetrahydrofolate synthase II: fabF dTDP-4-dehydro- transaminase dehydrogenase: AUL35_RS04990 [+ 11 isozymes] kinase subunit c-di-GMP biosynthesis I (E. coli) lipid II (meso carboxykinase: GalU: galU AUL35_RS00975 cyclohydrolase FolD: folD cob(I)yrinic acid a,c-diamide RecA filament- beta-ketoacyl-ACP 6-deoxy-α-D- (isomerizing) AUL35_RS18075 dehydrogenase/ 3-methylbutanoyl- a nucleoside DhaK: dhaK α α AUL35_RS10925 adenosyltransferase: cobO RNA CO H O DNA complex laurate -Kdo-(2->4)- -Kdo- diaminopimelate : glmS UDP-α-D-glucose a [protein] with Degradation/ a 5,10- methenyltetrahydrofolate diphosphate diphosphate 2 2 synthase I: fabB trehalose-6- glucopyranose γ (7Z)-hexadecenoyl-CoA S-(hydroxymethyl) AMP CoA a tRNA a uridylylated formaldehyde (2->6)-lipid IV (E. coli) containing) -L-glutamyl Utilization/ methenyltetrahydrofolate cyclohydrolase FolD: folD DHAP trp lipidA A biosynthesis an N-terminal 5- PII protein long-chain-fatty- CDP-diacylglycerol phosphoenol phosphate dTDP-4- D-glucosamine 5-phosphate glutathione glutathione containing a [DNA] lauroyl acyltransferase: oxo-L-proline acyl-CoA Assimilation - Other bifunctional a 5,10- adenosylcobalamin acid--CoA ligase: biosynthesis I pyruvate synthase: dehydrorhamnose 6-phosphate dehydrogenase/ triphosphate 3' CCA end a 3-oxotetradecanoyl-[acp] dehydrogenase: acrylonitrile methylenetetrahydrofolate AUL35_RS01290 α-Kdo-(2->4)-α-Kdo-(2->AUL35_RS02185 phosphopyruvate AUL35_RS08795 3,5-epimerase: rfbC phosphoglucosamine class III alcohol methenyltetrahydrofolate Glycolysis AUL35_RS00970 degradation I dehydrogenase/ DHAP 6)-(lauroyl)-lipid IV (E. coli) hydratase: dTDP-4-dehydro- mutase: dehydrogenase: bifunctional 3-oxoacyl-[acyl- lauroyl-CoA A β-L-rhamnose [+ 3 isozymes] methenyltetrahydrofolate AUL35_RS00290 AUL35_RS03980 AUL35_RS14035 methylenetetrahydrofolate 4 carrier-protein] myristoyl-acyl carrier acrylonitrile cyclohydrolase FolD: folD UDP-N-acetyl-α-D-muramoyl- an O - a 2'- an N-terminal- an N-terminal- a glucosylated dTDP-4- α-D-glucosamine glycolysis III (from glucose) (2E,7Z)- dehydrogenase/ di-trans,octa-cis- a [protein]- an acyl-[acyl- + L(or D)-O- protein-dependent 2-phospho- alpha-D-glucose 5-oxo-L-proline γ methylthymine deoxyribonucleoside L-methionyl-L- malonyl-CoA H a protein L-methionyl- pyrazinamide glycogenin reductase: fabG α α an N 10 - L-alanyl- -D-glutamyl-L- L-cysteine [DNA] sn-glycerol phosphate-specific , -trehalose dehydrorhamnose 1-phosphate hexadecenoyl-CoA S-formylglutathione methenyltetrahydrofolate undecaprenyl phosphate carrier protein] phosphoserine 1,4-alpha- acyltransferase: D-glycerate lysyl-D-alanyl-D-alanine in DNA 5'-triphosphate cysteinyl-[protein] glycyl-[protein] amidase: + H + 3-phosphate 6-phosphate reductase: rfbD 5-oxoprolinase formyltetrahydrofolate cyclohydrolase FolD: folD ATP-dependent H FliI a (3R)-3-hydroxytetradecanoyl-[acp] AUL35_RS02185 phosphoglucomutase: bifunctional UDP-N- D-glucopyranose AUL35_RS07300 phosphoserine glucan dTDP-β-L- subunit acrylamide S-formylglutathione Clp protease: glycerol-3- α α AUL35_RS06595 trehalose- acetylglucosamine formyltetrahydrofolate a 5,10- type III polyketide phosphatase branching -D-Kdo-(2->4)- -D- hydrolase: fghA phospho-N- methylated-DNA-- phosphate DNA polymerase type I methionyl AUL35_RS16815 clpX type I methionyl bifunctional phosphatase: rhamnose glucokinase: PxpB: pxpB methylenetetrahydrofolate synthase: SerB: serB protein 3-hydroxyacyl- stearate biosynthesis phosphate 1-O- Kdo-(2->6)-lipid A (E. coli) diphosphorylase/ (S)-3-hydroxy-(7Z) deformylase: purU acetylmuramoyl- [protein]-cysteine S- acyltransferase III subunit delta: aminopeptidase: aminopeptidase: nicotinamidase/ AUL35_RS03415 amidase: AUL35_RS12320 ATP-dependent Clp 2+ 2+ ACP dehydratase acyltransferase 3-phospho- otsB glucosamine-1- methyltransferase: GlgB: glgB Mg MgtA Mg II (bacteria and plants) glu -hexadecenoyl-CoA AUL35_RS07300 formate pentapeptide- PlsX: plsX AUL35_RS12680 map protease ATP-binding map pyrazinamidase: serine FabZ: fabZ PlsY: plsY D-glycerate phosphate N- D-glucopyranose formate AUL35_RS06910 α,α-trehalose transferase: [+ 13 isozymes] subunit ClpA: clpA pncA a glycogen a 1-acyl-sn phosphoglycerate Calvin-Benson-Bassham cycle acetyltransferase 6-phosphate pyrazine-2- 3-hydroxyacyl-[acyl- a palmitoyl-[acp] acrylate AUL35_RS03620 octoketide -glycerol 3- GlmU: glmU an N-terminal L- a peptide an N-terminal carboxylate carrier-protein] beta-ketoacyl- kinase: pgk maltose alpha-D- glucose-6- a [protein]-S- 2+ CadA Cd 2+ phosphate a thymine in DNA acyl-carrier protein an acyl phosphate met cysteinyl-[protein] met glycyl-[protein] Cd dehydratase ACP synthase glucosyltransferase: CO N-acetyl-α-D- phosphate 3-oxo-(7Z)- methyl-L-cysteine [DNA] D-ribulose-1,5- 2 undecaprenyl-diphospho-N- UMP 1-acyl-sn-glycerol- phosphatidylcholine 13-DPG treS glucosamine isomerase: hexadecenoyl-CoA FabA: fabA II: fabF bisphosphate N 6 -L-threonylcarbamoyladenosine 37 acetylmuramoyl-L-alanyl-γ-D- 3-phosphate biosynthesis VI ribulose 1,5- 1-phosphate AUL35_RS06575 Amine and Polyamine Degradation beta-ketoacyl- maltose alpha-D- -modified tRNA biosynthesis 3-ketoacyl- glutamyl-L-lysyl- D-alanyl-D-alanine acyltransferase: bisphosphate Cd 2+ CadA Cd 2+ a (2E)-tetradec-2-enoyl-[acp] a CDP- triose-phosphate type I glucosyltransferase: bifunctional UDP-N- CoA thiolase: ACP synthase AUL35_RS16325 choline α carboxylase: F6P diacylglycerol isomerase: glyceraldehyde- -D- treS acetylglucosamine AUL35_RS08135 ethanolamine utilization I: fabB urea degradation II 6 enoyl-ACP a 3-oxooctadecanoyl- 1-acyl-sn-glycerol- AUL35_RS09435 glucopyranose AUL35_RS02830 thr N-acetylglucosamine allantoin degradation UDP-N-acetyl-α-D- a [protein]- an O - a [DNA]-3'- 4-nitrophenyl L-fuculose 3-phosphate ADP-α-D-glucose diphosphorylase/ 3-ketoacyl- choline-O-sulfate di-trans,octa-cis- 2-methylbutanoate a uracil in DNA cadaverine putrescine (S)-NADPHX α-amylose [acp] 3-phosphate 1-phosphate α-maltose threonylcarbamoyl- degradation II to glyoxylate I muramoyl-L-alanyl-γ-D- L-cysteine methylguanine 1-phosphate repressor LexA reductase FabI: fabI phosphatidylcholine/ triose-phosphate dehydrogenase: glucosamine-1- ethanolamine degradation undecaprenyl phosphate hydroxyl palmitate heme b CcmA AMP synthase: CoA thiolase: N-acetyl-D- in DNA NAD(P)H-hydrate 1,4-alpha- heme b enoyl-ACP acyltransferase: phosphatidylserine isomerase: gap phosphate N- urea glutamyl-L-lysyl-D-alanine 3-oxoacyl- β AUL35_RS01550 AUL35_RS00975 (S)-(+)-allantoin dehydratase: transcriptional glucan reductase FabI: fabI AUL35_RS10770 synthase: AUL35_RS00310 D-ribulose 3-phospho- -D-fructose 1,6- (L-threonylcarbamoyl) ethanolamine glucosamine choline sulfate urease: [acyl-carrier- D-glyceraldehyde acetyltransferase N-acetylglucosamine acetate- exodeoxyribonuclease uracil-DNA homospermidine L-fuculose- AUL35_RS08590 repressor branching a 1,2-diacyl- AUL35_RS19085 DHAP 5-phosphate bisphosphate adenylate (5Z)-tetradecenoyl-CoA allantoinase AUL35_RS13305 phospho-N- methylated-DNA-- arylesterase: protein] 3-phosphate ribose-5- D-glycerate GlmU: glmU ammonia- kinase: choline- -CoA III: AUL35_RS19835 glycosylase: synthase: phosphate LexA: lexA protein a myristoyl-[acp] sn-glycerol PuuE: puuE ureC [protein]-cysteine S- AUL35_RS18510 NAD(P)H-hydrate a reduced reductase: α-maltose 1- phosphate tRNA (adenosine(37)-N6)- lyase: eutB eutC AUL35_RS18305 sulfatase: betC acetylmuramoyl- ligase: acs AUL35_RS15780 AUL35_RS16910 aldolase: 3-phosphate UDP-N-acetyl- acyl-CoA N-acetyl-D- allantoate methyltransferase: exodeoxyribonuclease dehydratase: cleaved GlgB: glgB H O c-type phosphate isomerase α fructose- urease subunit pentapeptide- AUL35_RS08090 2 cytochrome fabG phosphatidate a phosphatidylcholine -D-glucosamine threonylcarbamoyltransferase dehydrogenase: glucosamine choline AUL35_RS06910 III: xth [+ 2 isozymes] repressor LexA cytochrome beta-ketoacyl-ACP bisphosphate acetaldehyde gamma: transferase: AUL35_RS14280 amylopectin c oxidase an oxidized a (3R)-3- cytidylyltransferase: alpha-1,4-glucan-- RpiA: rpiA phosphoglycerate complex ATPase subunit (2S)-2- synthase II: fabF aldolase class II: AUL35_RS01520 6-phosphate choline allantoicase: AUL35_RS03620 4-nitrophenol palmitate N-(4-aminobutyl) NADPH O c-type hydroxyoctadecanoyl- ribulose-phosphate D-ribose 5- type 1 TsaE: tsaE AUL35_RS13295 2 AUL35_RS00395 GDP-mannose biosynthesis maltose-1-phosphate kinase: pgk N-acetylglucosamine- methylbutanoyl- AMP diphosphate a 2'- -cadaverine a reduced beta-ketoacyl-ACP phosphate AUL35_RS09430 [+ 3 isozymes] dehydrogenase: alc ammonium a [protein]-S- a [DNA]-3'- an apyrimidinic uracil DHAP (S)-lactaldehyde cytochrome [acp] fructose- maltosyltransferase: 3-epimerase: [+ 2 isozymes] alcohol 6-phosphate a guanine in DNA CoA deoxyribonucleoside synthase I: fabB a CDP- 6 (2E,5Z)- betA methyl-L-cysteine hydroxyl site in DNA H O c-type 3-hydroxyacyl- D-glucopyranose AUL35_RS06475 class I fructose- an N -L- dehydrogenase undecaprenyl-diphospho-N UMP 2 cytochrome diacylglycerol bisphosphate AUL35_RS13420 D-xylulose transketolase: tkt glycogen biosynthesis I (from ADP-D-Glucose) deacetylase: nagA (S)-ureidoglycolate 5'-monophosphate cytochrome ACP 6-phosphate 13-DPG bisphosphate threonylcarbamoyladenine 37 tetradecenoyl-CoA AdhP: adhP -acetylmuramoyl-L-alanyl-γ- an oxidized aldolase class II: glucose-6- a (1->4)- 5-phosphate D-glucosamine betaine aldehyde c oxidase a 3-oxohexadecanoyl-[acp] dehydratase D-sedoheptulose aldolase: in tRNA acetyl-CoA ureidoglycolate D-glutamyl-L-lysyl- D-alanine O c-type AUL35_RS09430 α-D-glucan 2 FabZ: fabZ phosphate 7-phosphate 6-phosphate a cytochromereduced 3-oxoacyl-[acyl- D-glucopyranose 6-phosphate AUL35_RS08950 betaine-aldehyde lyase: class I fructose- isomerase: 1,4-alpha- transketolase: tkt bifunctional enoyl- ethanol H O c-type 3-hydroxyacyl- dehydrogenase: AUL35_RS13350 β-D-fructofuranose a [lipoyl-carrier a (1->4)- 2 carrier-protein] bisphosphate AUL35_RS06575 glucan CoA hydratase/ quinoxaline-2- a [release factor]- (2R,3S)-3- a double alpha-D-glucose (3E,5Z)-tetradeca- (S)-3-hydroxy-(5Z) isobutanoate an alkylated DNA 6 α RS08905 cytochrome reductase: fabG [acyl-carrier- aldolase: F6P betB aryl-carrier protein carboxyl adenylate DL-allothreonine 1-phosphate L-glutamine isopropylmalate protein]-N -[(R) stranded DNA a protein -D-glucan an oxidized branching phosphate-specific triose-phosphate phosphate glyoxylate 1,4-alpha- protein] D-sedoheptulose 3,5-dienoyl-CoA -tetradecenoyl-CoA α-D-glucosamine peptide chain 3-isopropylmalate -dihydrolipoyl]- DNA O c-type AUL35_RS08950 protein isomerase: acetyltransferase: glycine betaine 2 dehydratase mannose-1-phosphate phosphoglucomutase: 6-phosphate release factor dehydratase L-lysine topoisomerase glucan cytochromea reduced a (3R)-3-hydroxyhexadecanoyl-[acp] 1,7-bisphosphate AUL35_RS02975 dihydrolipoyl metalloprotease GlgB: glgB D-glyceraldehyde AUL35_RS06595 AUL35_RS09435 Pentose Phosphate Pathways DNA-3- class I fructose- large subunit: leuC branching H O c-type FabA: fabA fatty acid biosynthesis guanylyltransferase/ F6P acyl carrier protein: acetate--CoA serine N(5)-glutamine dehydrogenase: (ATP- TldD: tldD 2 3-phosphate α-D-glucopyranose triose-phosphate methyladenine bisphosphate protein cytochrome cytochrome 3-hydroxyacyl- initiation (type II) mannose-6- a GlgE-glycogen triose-phosphate acetyl phosphate AUL35_RS02415 ligase: acs hydroxymethyltransferase: methyltransferase: 3-isopropylmalate AUL35_RS12880 hydrolyzing) c oxidase an oxidized a (2E)-octadec- class II fructose- class I fructose- 1-phosphate isomerase: pentose phosphate (3E,5Z)- 3-oxo-(5Z)- glycosylase: aldolase: GlgB: glgB ACP dehydratase phosphate isomerase: isomerase: AUL35_RS00780 prmC dehydratase dihydrolipoyl subunit B: gyrB O c-type 2-enoyl-[acp] acyl carrier protein: AUL35_RS08950 5 a peptide 2 bisphosphatase: bisphosphate AUL35_RS00310D-glyceraldehyde pathway (oxidative branch) I tetradecadienoate tetradecenoyl-CoA AUL35_RS04120 a [release factor]-N starch FabZ: fabZ acetyl-CoA β-D-fructose 1,6- AUL35_RS16840 AUL35_RS09435 glucose-1-phosphate DHAP acetate/propionate F6P AUL35_RS02160 small subunit: leuD dehydrogenase: [+ 2 isozymes] cytochrome enoyl-ACP glpX aldolase: 3-phosphate 3-ketoacyl- -methyl-L-glutamine (2S)-2- a negatively 3-hydroxyacyl-[acyl- acetyl-CoA bisphosphate D-mannopyranose triose-phosphate adenylyltransferase: D-glucopyranose family kinase: isobutanoyl-CoA diphosphate a [lipoyl-carrierlpdA reductase AUL35_RS08950 CoA thiolase: AMP a DNA containing isopropylmalate supercoiled DNA carrier-protein] carboxylase 6-phosphate class 1 fructose- glgC type I 6-phosphate AUL35_RS02980 acetaldehyde an alkylated D-glyceraldehyde protein]-N 6 -[(R class II fructose- α isomerase: glucose-6- a quinoxaline-2- gly an apurinic/ DHAP FabI: fabI carboxyltransferase UDP- -D-galactofuranose bisphosphatase: glyceraldehyde- AUL35_RS08135 nucleobase )-lipoyl]-L-lysine dehydratase bisphosphatase: phosphomannomutase: AUL35_RS00310 a (1->4)-α-D-glucan ADP-α-D-glucose phosphate carboxyl-[aryl- apyrimidinic site enoyl-ACP subunit beta: biosynthesis β-D-fructoseAUL35_RS06480 1,6- 3-phosphate (3Z)-dodec- acetate AMP FabA: fabA glpX AUL35_RS16835 dehydrogenase: Aromatic Compound Degradation carrier protein] reductase AUL35_RS11000 bisphosphate DHAP glycogen dehydrogenase: 3-enoyl-CoA class 1 fructose- α-D-mannose UDP-α-D-glucose zwf a (2E)-hexadec-2-enoyl-[acp] FabI: fabI malonyl-CoA synthase gap 6-phospho bisphosphatase: 4-hydroxyphenylacetate 1-phosphate UDP-glucose 4- GlgA: glgA D-glucono- 4-sulfocatechol chlorpyrifos degradation degradation an N 6 -L- an N-terminal an [RNA]-3'- 6-O-cis-methoxy- enoyl-ACP a stearoyl-[acp] ACP S- AUL35_RS06480 epimerase GalE: galE 1,5-lactone a peptidoglycan (2S)- D-sedoheptulose mannose-1-phosphate α α 13-DPG degradation a sulfurated 37 an L-arginyl- O-succinyl-L- (S)-2- an unfolded malonyltransferase: UDP- -D-galactose a (1->4)- -D-glucan (2E)-dodec- threonylcarbamoyladenine 3-sulfo-L- dimer (generic) glu ribonucleoside- ethylmalonyl-CoA 1-phosphate phenyl acetate mycolyl-trehalose reductase FabI: fabI guanylyltransferase/ 6-phosphogluconolactonase: (4-hydroxyphenyl) [tRNA Arg ] homoserine aminobutanoate protein F6P fructose- chlorpyrifos [sulfur carrier] in tRNA alanyl-[protein] 2',3'- methylmalonyl- 6-phosphate fabD mannose-6- UDP-galactopyranose PRPP biosynthesis 1,4-alpha-glucan 2-enoyl-CoA acetate enoyl-ACP bisphosphate phosphoglycerate pgl 4-hydroxyphenylacetate 4-sulfocatechol phosphotriesterase: cyclophosphate CoA epimerase: trehalose- glucose-6- phosphate isomerase: mutase: glf branching kinase: pgk protocatechuate lytic murein RNA 2',3'-cyclic class I fructose- chaperonin reductase FabI: fabI a malonyl-[acp] D-ribose 5- aldolase class II: D-gluconate 3-monooxygenase: AUL35_RS10175 AUL35_RS07420 arylesterase: phosphatase: AUL35_RS16840 protein GlgB: glgB 3,4-dioxygenase: tRNA (N(6)-L- O-succinylhomoserine transglycosylase: glutamate-- phosphodiesterase: bisphosphate GroEL: groL phosphate UDP-Galf AUL35_RS09430 3-phospho- 6-phosphate AUL35_RS09605 arginyltransferase: otsB stearate phosphate diethylthiophosphate threonylcarbamoyladenosine(37) sulfhydrylase: AUL35_RS16945 cysteine ligase: methylmalonyl- AUL35_RS18510 trehalose- a palmitoyl-[acp] isomerase: GDP-α-D- ribose-phosphate (S)-3- (3,4-dihydroxyphenyl) pcaH pcaG AUL35_RS00810 an [RNA]-3'-thpR aldolase: ketoacyl-ACP class I fructose- a glycogen D-glycerate decarboxylating 6- -C(2))- methylthiotransferase AUL35_RS15410 AUL35_RS06815 CoA cis-methoxy- AUL35_RS06575 mannose pyrophosphokinase: prs hydroxydodecanoyl-CoA acetate 3-sulfomuconate [+ 6 isozymes] ribunucleoside- AUL35_RS08950 a protein long-chain-fatty- synthase III: fabH bisphosphate phosphogluconate epimerase: mce mono-mycolate long-chain fatty D-glucopyranose PRPP 2,3-bisphosphoglycerate- MtaB: mtaB acid--CoA ligase: aldolase: dehydrogenase: gnd an N-terminal L- 2'-phosphate (2R)- acetate phenol acid activation 6-phosphate dependent GlcNAc-1,6- γ-L-glutamyl-(S)- AUL35_RS01290 AUL35_RS08950 Arg arginiyl-3-sulfo- ethylmalonyl-CoA NADP-dependent 6 a tRNA succinate a lipid II D-erythrose an acetoacetyl-[acp] a long-chain phosphoglycerate 2-hydroxy-5- a 2-methylsulfanyl-N -L- L-homocysteine anhydro-MurNAc- 2-aminobutanoate DHAP phosphogluconate protocatechuate degradation diethylphosphate 37 an unsulfurated L-alanyl-[protein] palmitate stearoyl-CoA mutase: carboxymethylmuconate threonylcarbamoyladenine 5'-deoxyadenosine met pentapeptide fatty acidlong-chain-fatty- dehydrogenase: gndA 3-oxododecanoyl-CoA II (ortho-cleavage pathway) 4-sulfomuconolactone [sulfur carrier] AUL35_RS03430 semialdehyde in tRNA long-chain-fatty- acid--CoA ligase: D-ribulose 2-phospho- 3-ketoacyl- acid--CoA ligase: AUL35_RS01290 5-phosphate protocatechuate a long-chain D-glycerate CoA thiolase: AUL35_RS01290 protocatechuate a nascent peptidoglycan an N-terminal an N-formyl-L- 4-nitrophenyl hydrogen succinate 6-O-trans-keto- a 2,3,4- fatty acyl-CoA AUL35_RS00975 an L-arginyl- 2-oxoglutarate leukotriene-D4 a holo [PedD acyl- A(H2) phosphopyruvate 3,4-dioxygenase: (meso-DAP containing) 3-sulfino-L- methionylaminoacyl- D-ala peroxide mycolyl-trehalose saturated (3R)-3- 5-carboxymethyl-2- [tRNA Arg ] carrier protein] butanoate semialdehyde palmitoyl-CoA Secondary Metabolite Biosynthesis hydratase: pcaH pcaG 2-maleylacetate methyl parathion degradation alanyl-[protein] tRNA NAD-dependent 6-phosphate hydroxyacyl-CoA Amino Acid Biosynthesis decanoyl-CoA hydroxymuconate acetoacetyl- AUL35_RS00290 3-carboxy-cis,cis-muconate ACP S- succinate- trehalose- lytic murein CoA acyl-CoA membrane malonyltransferase: arylesterase: catalase/ semialdehyde phosphatase: methylerythritol phosphate pathway I β phosphoenol pyruvate Fermentation methyl parathion transglycosylase: peptide D-amino-acid reductase: L-histidine biosynthesis flexixanthin preQ biosynthesis -carotene 3-carboxy- arginyltransferase: dipeptidase: fabD peroxidase otsB superpathway of branched chain amino acid biosynthesis L-lysine biosynthesis I L-arginine biosynthesis II (acetyl cycle) 0 pyruvate dehydrogenase: deformylase: transaminase: AUL35_RS18510 dehydrogenase: trehalose- L-proline biosynthesis L-methionine biosynthesis III biosynthesis biosynthesis fermentation cis,cis-muconate AUL35_RS16945 AUL35_RS00810 AUL35_RS05185 a malonyl- HPI: katG phbB D-glyceraldehyde AUL35_RS00970 (3E,5R)-5-carboxy-2- AUL35_RS13635 AUL35_RS17910 AUL35_RS10320 trans-keto- a 2,3,4-saturated I (from L-glutamate) pyruvate pyruvate to ethanol II cycloisomerase: 3-oxoadipate phosphotriesterase: [+ 6 isozymes] [PedD acyl- PRPP N-acetylglutamyl- 3-phosphate [+ 3 isozymes] oxohept-3-enedioate succinate mono-mycolate 3-oxoacyl-CoA pyruvate uracil degradation all-trans-lycopene all-trans-lycopene kinase: pyk pyruvate AUL35_RS05830 AUL35_RS10175 carrier protein] thr asp phosphate L-homoserine GTP an N-terminal L- butanoate 4-nitrophenol I (reductive) carotenoid lycopene a mature peptidoglycan a nascent peptidoglycan leukotriene-E4 A H O glu 1-deoxy-D-xylulose- ubiquinone- (2E)-dec-2-enoyl-CoA (2-carboxy-2,5-dihydro- Arg a L-methionylaminoacyl- gly 2 ATP acetolactate aspartate kinase: GTP beta-cyclase pyruvate a tRNA arginiyl-3-sulfino- formate pyruvate uracil 1,2-hydratase: dependent 5-oxofuran-2-yl)-acetate with (L-alanyl-γ-D-glutamyl- (meso-DAP containing) tRNA D-glt BamA phosphoribosyltransferase threonine synthase: ilvN AUL35_RS16090 N-acetyl- glutamate 5-kinase: homoserine O- 5-phosphate cyclohydrolase dimethylthiophosphate 4-nitrophenol L-alanyl-[protein] AUL35_RS13590 7,8- CrtY: crtY pyruvate (4Z)-2-oxohept- meso-2,6-diaminopimeloyl- with GlcNAc terminus potassium- regulatory subunit: ammonia- AUL35_RS00865 gamma- AUL35_RS02765 acetyltransferase: synthase: I FolE: folE γ-carotene 4-carboxymuconolactone L-aspartyl-4-phosphate γ-L-glutamyl rhodopin dihydroneopterin dehydrogenase: 4-enedioate parathion degradation D-alanine) tetrapeptide K + transporting K + AUL35_RS06755 lyase glutamyl- AUL35_RS16300 AUL35_RS01495 decarboxylase: pcaC 5-phosphate 3'-triphosphate poxB ATPase ATP IlvA: ilvA (S)-2-acetolactate phosphate 5,6-dihydrouracil lycopene (S)-3- aspartate- O-acetyl-L- acetaldehyde (4,5-dihydro-5- phosphoribosyltransferase: (2Z)-2-aminobut- reductase: 1-deoxy-D-xylulose 6-carboxytetrahydropterin beta-cyclase hydroxydecanoyl-CoA parathion 34 a thiocarboxylated a [protein] N- 4-methyl-3- ketol-acid homoserine hydrogen sulfide oxofuran-2-yl)-acetate pyruvate coenzyme A an apo [peptidyl- a uridine carbamoyl a holo [BryU acyl- a ribonucleoside D-glucopyranose L-threonine 3- a nucleoside AUL35_RS06750 2-enoate semialdehyde acetylglutamate argC dihydropyrimidinase: 5-phosphate synthase: AUL35_RS07515 CrtY: crtY [SAMP] C- L-ornithine terminal-formyl- oxoadipate- reductoisomerase: alcohol (4S)-4-hydroxy-2- carrier protein] in tRNA phosphate carrier protein] diphosphate O-phosphate triphosphate dehydrogenase: kinase: argB hydA 3,4- 3-oxoadipate enol- terminal glycine L-methionine vitamin B12- glucose 1- nucleoside enol-lactone 1-(5-phospho- ilvC 6-carboxy-5,6,7,8- β dehydrogenase oxoheptanedioate phosphotriesterase: 3-oxoadipate AUL35_RS17695 gln N-acetyl-L-glutamate L-glutamate-5- dihydropyrimidinase: didehydrorhodopin -carotene lactonase: pcaD paraoxon degradation ACP S- dehydrogenase: threonine- β-D-ribosyl)-ATP (2R)-2,3- glu N-acetyl-L-glutamate tetrahydropterin AdhP: adhP AUL35_RS10175 pyruvate, dependent triphosphate enol- 5-semialdehyde semialdehyde holo-ACP tRNA 2- malonyltransferase: AUL35_RS15005 phosphate dihydroxy-3- L-aspartate 4- bifunctional hydA lycopene 3-oxodecanoyl-CoA ornithine peptide ribonucleotide hydrolase: lactonase: phosphoribosyl- 3-oxoadipate phosphate fabD decarboxylase: semialdehyde glutamate N- glutamine- N-acetylornithine beta- ethanol paraoxon synthase: thiouridine(34) carbamoyltransferase: deformylase: reductase: glucose 1- AUL35_RS13905 ATP 2-iminobutanoate methylbutanoate 3-ureidopropanoate MEP dikinase: a malonyl- (R)-1-amino-AUL35_RS08485 pcaD acetyltransferase/ hydrolyzing bifunctional aminotransferase: L-homocysteine cyclase 3-ketoacyl- diethylthiophosphate 4-nitrophenol AUL35_RS15650 synthase argF AUL35_RS13635 AUL35_RS00615 dehydrogenase: a nucleoside 4-methyl-3- diphosphatase: dihydroxy-acid 4-hydroxy- AUL35_RS01300 [BryU acyl- a 2'- 2-propanol O amino-acid carbamoyl- glutamate N- AUL35_RS15450 CrtY: crtY 7-carboxy-7- CoA thiolase: succinate semialdehyde MnmA: mnmA AUL35_RS10815 diphosphate oxoadipate AUL35_RS12445 dehydratase: tetrahydrodipicolinate bifunctional 2-C- phosphotriesterase: carrier protein] deoxyribonucleoside -2-phosphate acetyltransferase phosphate acetyltransferase/ (S)-1-pyrroline- methionine methionine deazaguanine AUL35_RS00975 D-glucono- β ilvD synthase: methyl-D-erythritol myxocoxanthin AUL35_RS10175 3',5'-ADP a holo [peptidyl- an N-terminal L- 5'-diphosphate 1-(5-phospho- - ArgJ: argJ synthase: 5-carboxylate synthase: synthase: phosphoenol 34 1,5-lactone amino-acid + carrier protein] a [SAMP] C- a 2-thiouridine formate dihydroxy-acid AUL35_RS15695 4-phosphate octanoyl-CoA diphosphate H L-citrulline methionyl-[protein] D-ribosyl)-AMP 2-oxobutanoate carA carB acetyltransferase pyrroline-5- metH metH pyruvate fermentation to acetoin III AMP pyruvate terminal glycine in tRNA dehydratase: (2S,4S)-4- β-alanine cytidylyltransferase/ beta-carotene phosphoribosyl- hydroxy-2,3,4,5- ArgJ: argJ carboxylate 2-C-methyl-D- ketolase: acyl-CoA diethylphosphate diethylphosphate 4-nitrophenol acetolactate AUL35_RS10435 carbamoyl phosphate L-ornithine succinate AMP tetrahydrodipicolinate reductase: met erythritol 2,4- AUL35_RS07710 preQ pyruvate dehydrogenase: cyclohydrolase: synthase: ilvN 3-methyl-2- N-acetyl-L-ornithine L-threonine 0 4-hydroxy- AUL35_RS06355 cyclodiphosphate AUL35_RS00970 hisI AUL35_RS00865 oxobutanoate biosynthesis deoxyflexixanthin a [2-oxoglutarate- an apo-[LYS2 L- an [amino-group carrier (3R)-3- tetrahydrodipicolinate alanine synthase: ubiquinone- [+ 3 isozymes] a sulfurated coenzyme A an (R)-2- an N α -methyl aci-nitroethane a holo [BryP acyl- D-glucopyranose [DNA] 1-(5-phospho-β-D-ribosyl)- (S)-2-aceto-2- pro SAM dehydrogenase 2-aminoadipyl- protein]-C-terminal-γ- hydroxyoctadecanoyl- thr reductase: racemization AUL35_RS00230 dependent pyruvate [sulfur carrier] halocarboxylate L-amino acid carrier protein] 5-[(5-phosphoribosylamino) hydroxybutanoate 2-isopropylmalate branched-chain ubiquinone- (2E)-oct-2-enoyl-CoA Amino Acid Degradation E2 protein] N 6 - carrier-protein] (L-glutamyl)-L-glutamate glucose 1- DNA CoA AUL35_RS03425 L-homoserine 4-(cytidine 5'- dehydrogenase: poxB acetoacetyl- threonine methylideneamino]imidazole- synthase: leuA octanoyl-L-lysine ACP S- dehydrogenase: polymerase ketol-acid amino acid ala diphospho)-2-C- dependent pyruvate nitronate acetylglutamate CoA ammonia- 4-carboxamide (S)-2,3,4,5- ornithine homoserine kinase: ubiquinone- holo-ACP HAD family malonyltransferase: AUL35_RS10815 IV: dinB reductoisomerase: aminotransferase: alanine methyl-D-erythritol dehydrogenase: poxB L-leucine degradation I L-proline degradation I N-methyl-L- monooxygenase: kinase: argB reductase: lyase (2S)-2- tetrahydrodipicolinate carbamoyltransferase: AUL35_RS01390 flexixanthin dependent pyruvate L-threonine L-tryptophan degradation to L-arginine degradation lipoyl synthase: hydrolase: fabD [+ 6 isozymes] 1-(5-phosphoribosyl)-5- ilvC AUL35_RS09010 superpathway of L-serine racemase: O-phospho- 4-(cytidine 5'- acetaldehyde tryptophan a malonyl- an [amino-group carrier glucose 1- a 2'- phbB IlvA: ilvA 2,3,4,5- argF degradation I L-histidine synthase: AUL35_RS15650 AUL35_RS17240 AUL35_RS10680 [(5- phosphoribosylamino) isopropylmalate and glycine biosynthesis I dehydrogenase: poxB 2-amino-3-carboxymuconate II (AST pathway) oxidase: solA protein]-C-terminal- dehydrogenase: 3-oxooctadecanoyl- (R)-2,3-dihydroxy- branched-chain alr L-homoserine diphospho)- (S)-3- degradation II [BryP acyl- deoxyribonucleoside 2-oxobutanoate methylideneamino]imidazole-4- 3-isopropylmalate tetrahydropyridine- leu semialdehyde pro lipA [+ 4 isozymes] γ AUL35_RS15005 CoA 3-methylpentanoate amino acid L-tryptophan biosynthesis D-ala threonine 2-C-methyl-D- hydroxyoctanoyl-CoA carrier protein] -(5-phospho-L- 5'-monophosphate carboxamide isomerase: hisA dehydratase 2,6-dicarboxylate N- 3-phospho-D-glycerate branched-chain thr arg a holo-[LYS2 L- D-glucono- dihydroxy-acid aminotransferase: synthase: erythritol kinase: acetoin trp bifunctional a [2-oxoglutarate 3',5'-ADP acetaldehyde nitrite glutamyl)-L-glutamate small subunit: leuD succinyltransferase: phosphoglycerate amino acid threonine his an unsulfurated 2-aminoadipyl- formaldehyde 1,5-lactone phosphoribulosylformimino- dehydratase: AUL35_RS06330 AUL35_RS01610 proline L-citrulline degradation 5'-deoxyadenosine dehydrogenase a halide anion an (S)-2- an L-amino acid dapD dehydrogenase: AUL35_RS01350 aminotransferase: ammonia- tryptophan 2,3- met carrier-protein] AICAR-phosphate ilvD 3-isopropylmalate chorismate gln 2-phospho-4-(cytidine astaxanthin biosynthesis (bacteria, fungi, algae) dehydrogenase/L- 6 [sulfur carrier] hydroxycarboxylate dioxygenase: 2 E2 protein] N N-succinyl-2-amino- AUL35_RS04000 AUL35_RS09010 lyase N -succinyl- dihydroxy-acid dehydratase L-citrulline thr 5'-diphospho)-2-C- 3-oxooctanoyl-CoA AUL35_RS09830 glutamate gamma- -lipoyl-L-lysine val 6-ketopimelate 3-phosphooxypyruvate IlvA: ilvA N-Formyl-L- urocanate L-arginine L-citrulline imidazole dehydratase: large subunit: leuC L-glutamate methyl-D-erythritol β branched-chain (2Z)-2-aminobut- semialdehyde anthranilate -carotene 3-ketoacyl- kynurenine ornithine glycerol AUL35_RS10435 argininosuccinate phosphoserine biosynthesis III bifunctional 2-C- ATP amino acid 2-enoate dehydrogenase synthase: an L-1- a peptide with 6 527 38- (3R)-3- 2-isopropylmaleate CoA thiolase: aminotransferase: carbamoyltransferase: an L-lysyl- an apo-[aryl- an (S)-2- a [histone]-N - a guanine a uridine phosphate synthase: transaminase: methyl-D-erythritol Metabolic Clusters biosynthesis PutA: putA phosphatidyl- coenzyme A an N-terminal a phenyl acetate hydroxypentanoyl- histidinol (3S)-3-methyl-2- AUL35_RS04905 beta-carotene AUL35_RS00975 (S)-1-pyrroline- argF Lys halocarboxylate acetyl-L-lysine in 16S rRNA 40 in tRNA a protein AUL35_RS18575 AUL35_RS03995 4-phosphate AUL35_RS06330 2 carbamoyl [tRNA ] carrier protein] synthase: oxopentanoate 3-isopropylmalate N-succinyl-L,L-2,6- 2-oxoglutarate 4-methyl-2- N -succinyl- 5-carboxylate sn-glycerol Xaa-L-proline 16S rRNA RluA family CoA histidinol glutamate cytidylyltransferase/ ketolase: 4-imidazolone- phosphate acetoacetyl- hisH hisF dehydratase diaminopimelate hexanoyl-CoA oxopentanoate L-ornithine (guanine(527)-N(7) pseudouridine dehydrogenase: branched-chain L-arginino-succinate anthranilate O-phospho-L-serine synthase: 2-C-methyl-D- AUL35_RS07710 N-end rule pathway I (prokaryotic) ADP histone endopeptidase La: CoA small subunit: leuD PRPP β 2-iminobutanoate L-kynurenine 5-propanoate glutamine- holo-ACP HAD family )-methyltransferase synthase: arylesterase: amino acid succinyl- -cryptoxanthin F0F1 ATP bifunctional leucyl AUL35_RS16825 reductase: hisD D-erythro-1- gltD gltB erythritol 2,4- leucyl/phenylalanyl- acyl-CoA hydrolase: deacetylase: 3-isopropylmalate diaminopimelate argininosuccinate hydrolyzing synthase: aminopeptidase: 7 RsmG: rsmG AUL35_RS16625 AUL35_RS18510 AICAR (imidazol-4- aminotransferase: cyclodiphosphate synthase: lysylphosphatidylglycerol AUL35_RS17240 AUL35_RS10655 an N - phbB dehydratase phosphoserine glu echinenone tRNA--protein dehydrogenase: 2 carbamoyl- AUL35_RS15650 3-oxopentanoyl- his AUL35_RS09010 desuccinylase: lyase: argH anthranilate N -succinyl- L-glutamate-5- flippase/synthetase AUL35_RS02360 methylguanine 527 [+ 2 isozymes] a peptide yl)-glycerol phosphatase SerB: serB synthase: AUL35_RS01635 AUL35_RS00970 3-methylbutanoyl- [+ 4 isozymes] a pseudouridine 38- large subunit: leuC dapE phosphoribosyltransferase: trpD transferase: L-glutamate 5- semialdehyde phosphate MprF: mprF CoA 3-phosphate branched-chain AUL35_RS00230 a [protein] AUL35_RS01640 CoA N-formimino- in 16S rRNA 40 in tRNA an N-terminal AUL35_RS14430 [+ 3 isozymes] synthase: acetate a phenol imidazoleglycerol- amino acid (2R,3S)-3- arg beta-carotene N-terminal L- AUL35_RS01645 isovaleryl-CoA 2-oxobutanoate 3-hydroxy- L-glutamate semialdehyde bifunctional 3',5'-ADP a holo-[aryl- a peptide with acetate a [histone]-L-lysine L,L-diaminopimelate ser 2-C-methyl-D-erythritol- zeaxanthin arginyl-[protein] carA carB an (S)-2- a proteinogenic phosphate aminotransferase: isopropylmalate N-(5-phosphoribosyl)-anthranilate ketolase: leucyl-L-arginine AUL35_RS01650 (2E)-hexenoyl-CoA dehydrogenase: L-kynurenine proline carrier protein] a halide anion an N-terminal 2,4-cyclodiphosphate 3-O-L-lysyl-1-O- amino acid 3-isopropylmalate AUL35_RS07710 a tRNA Lys hydroxycarboxylate L-proline dehydratase AUL35_RS06330 diaminopimelate serine [+ 3 isozymes] AUL35_RS02915 dehydrogenase/L- carbamate phosphatidylglycerol dehydrogenase: phosphoribosylanthranilate flavodoxin- 3-hydroxyechinenone kynureninase: HisB: hisB epimerase: hydroxymethyltransferase: leucyl/phenylalanyl- ATP 3-methylcrotonyl- N 2 - glutamate gamma- 3-(imidazol-4- ile leuB isomerase: AUL35_RS11015 dependent kynU semialdehyde AUL35_RS02595 AUL35_RS00780 canthaxanthin tRNA--protein CoA propanoyl-CoA N-formyl- succinylglutamate yl)-2-oxopropyl (2S)-2-isopropyl- (E)-4-hydroxy- beta-carotene dehydrogenase L-cysteine biosynthesis I 1-(2-carboxyphenylamino)-1- adonixanthin transferase: (S)-3- L-glutamate succinylglutamate adenine 2503 a [protein]- a DNA methyl 966 a supercoiled phosphate ketolase: acetyl/propionyl/ 3-hydroxyanthranilate AsbD acyl- a guanine an L-aspartyl- a [protein]- 3-oxosuccinate L-homoserine meso-diaminopimelate deoxy-D-ribulose 5-phosphate gly 3-methylbut- AUL35_RS14430 a [protein] hydroxyhexanoyl-CoA PutA: putA coenzyme A adenosylcobinamide dihydrolipoamide CAIR an N-terminal desuccinylase: in 23S rRNA L-cysteine phosphotriester in 16S rRNA Asn duplex DNA L-histidine histidinol- 2-enyl- AUL35_RS07710 N-terminal L- methylcrotonyl- N-formylglutamate CO carrier protein [tRNA ] hypoxanthine biosynthesis 2 bifunctional 16S rRNA indole-3-glycerol L-lysyl-[protein] CoA carboxylase AUL35_RS07425 pyruvate Asp-tRNA(Asn) UvrD-helicase sensor histidine 5-(carboxyamino) phosphate ser diphosphate leucyl-L-lysine amidohydrolase: glu adenosylcobinamide (guanine(966)-N(2) diaminopimelate phosphate subunit alpha: dehydrogenase /Glu-tRNA(Gln) domain-containing xanthine kinase KdpD: imidazole transaminase: ammonia assimilation cycle III synthase: ispG propanoyl AUL35_RS17000 23S rRNA methylated-DNA-- kinase/ )-methyltransferase L-phenylalanine asp decarboxylase: lysA synthase TrpC: trpC AUL35_RS06945 2-amino-3- glu holo-ACP complex amidotransferase: protein: dehydrogenase: AUL35_RS08540 ribonucleotide AUL35_RS16305 4-methyl-2- serine (E)-4-hydroxy-3- adonirubin phosphate (adenine(2503)-C(2) [protein]-cysteine S- biosynthesis I myo-inositol 3-oxohexanoyl-CoA carboxymuconate- synthase: adenosylcobinamide- dihydrolipoamide 2 RsmD: rsmD gatB gatA gatC AUL35_RS06130 a [protein]- mutase: purE oxopentanoate aspartate kinase: acetyltransferase: (1S,2R)-1-C-(indol-3- methylbut-2-en- [+ 2 isozymes] glu )-methyltransferase methyltransferase: an N - xdhA xdhB L-histidinol ammonium acetate/propionate AUL35_RS15650 phosphate acetyltransferase: 966 an L-asparaginyl- [+ 5 isozymes] 6,8- N-phospho- AIR AUL35_RS16090 lys AUL35_RS20080 yl)glycerol 3-phosphate biosynthesis TCA cycle 6-semialdehyde L-methionine degradation RlmN: rlmN AUL35_RS06910 methylguanine phosphate chorismate branched-chain 1-yl diphosphate acetyl-CoA C- 3-methylglutaconyl- family kinase: guanylyltransferase: AUL35_RS00265 [tRNA Asn ] a single dihydroxypurine L-histidine L-aspartyl- D-glucopyranose I (to L-homocysteine) in 16S rRNA amino acid serine O- glu glutamine 4-hydroxy- acetyltransferase: CoA L-tryptophan cobU stranded DNA histidinol- chorismate mutase: 4-phosphate tryptophan synthase: AUL35_RS02980 a holo-[AsbD acyl- S-acetyldihydrolipoamide acetyltransferase: synthetase: 3-methylbut- 6-phosphate TCA cycle I (prokaryotic) degradation I 2503 3',5'-ADP AUL35_RS06185 aminotransferase: AUL35_RS11005 trpB (3S,3'S)- AUL35_RS08135 a 2-methyladenine a [protein]-S- adenosyl-cobinamide phosphatase: cysE glutamate 2-enyl met 5'-deoxyadenosine carrier protein] [DNA] AUL35_RS09010 aspartate- AUL35_RS15245 astaxanthin [+ 2 isozymes] propanoate L-serine degradation (via anthranilate) in 23S rRNA met methyl-L-cysteine phosphate hisN prephenate ser 2-oxoglutarate synthase: methionine branched-chain semialdehyde glycine indole type I glutamate- diphosphate acetyl-CoA L-cysteine degradation III L-alanine O-acetyl-L-serine gltD gltB Ins(3)P trp adenosyltransferase: histidinol prephenate amino acid dehydrogenase: hydrogen sulfide biosynthesis IV -ammonia 4-hydroxy- reductase: butanoyl-CoA HMG-CoA biosynthesis III 3-methylbut- ispH tryptophan 2,3- AUL35_RS10735 dehydratase: aminotransferase: AUL35_RS17695 ligase: glnA ser 34 histidinol tryptophan synthase: inositol oxaloacetate acyl-CoA hydroxymethylglutaryl- cys dioxygenase: SAM an N-terminal an L-phenylalanyl- lysine within a [protein]-S- a uridine an (S)-2- a guanine 46 a cytidine 34 an L-glutamyl- all-trans AUL35_RS21970 AUL35_RS06330 thr 2-enyl L-serine an octanoyl-[acp] chlorophyll a a DNA segment L-aspartate 4- cysteine synthase AUL35_RS11005 trpB IPP monophosphatase: dehydrogenase: Phe gcv protein H sulfanyl-L-cysteine in tRNA halocarboxylate in tRNA Gln neurosporene dehydrogenase: cys diphosphate citrate (Si)-synthase: gltA CoA lyase: ammonia-lyase: N-Formyl-L-AUL35_RS09830 arginyl-[protein] [tRNA ] in tRNA [tRNA ] purine 3-phenyl-2- semialdehyde A: AUL35_RS00550 low specificity L- glutamate AUL35_RS09475 AUL35_RS00970 tRNA tRNA (cytidine(34) lycopene hisD cysteine ammonium gln reductase: AUL35_RS02930 AUL35_RS10255 kynurenine Asp-tRNA(Asn) recombinase oxopropanoate leu threonine aldolase: synthase: [+ 3 isozymes] 2-aminoprop- (guanosine(46)-N7) -2'-O)- beta- homoserine desulfurase: cysteine ispH [+ 2 isozymes] tRNA 2- /Glu-tRNA(Gln) xanthine RecA: recA histidinal AUL35_RS16980 trp gltD gltB type 2 isopentenyl- acetoacetate 2-enoate leucyl/phenylalanyl- lipoyl(octanoyl) HAD family chlorophyllase: -methyltransferase methyltransferase: cyclase dehydrogenase: sufS synthase A: cysK thiouridine(34) amidotransferase: dehydrogenase: [+ 3 isozymes] gly diphosphate myo-inositol crotonyl-CoA tRNA--protein transferase hydrolase: AUL35_RS13650 TrmB: trmB AUL35_RS05005 a DNA segment CrtY: crtY [+ 5 isozymes] malate dehydrogenase: 3-mercaptopyruvate an N 7 - a 2'-O- gatB gatA gatC xdhA xdhB histidinol AUL35_RS09665 ala Delta-isomerase: (S)-malate citrate SAH synthase AUL35_RS17240 transferase: LipB: lipB 46 34 an L-glutaminyl- in reverse β [+ 2 isozymes] AUL35_RS10575 L-arginine methylguanine methylcytidine 8-hydroxypurine -zeacarotene dehydrogenase: AUL35_RS06485 MnmA: mnmA [+ 5 isozymes] [tRNA Gln ] phe cys degradation L-kynurenine AUL35_RS14430 in tRNA in tRNA orientation hisD aconitate hydratase 3-mercaptopyruvate adenosylhomocysteinase: a [glycine-cleavage L-homoserine III (arginine 2-iminopropanoate chlorophyllide a phytol glu AUL35_RS10960 acyl-carrier protein complex H protein] 34 AcnA: acnA (S)-3- sulfurtransferase: L-phenylalanyl-L- a [protein]- a 2-thiouridine a (2R)-2- DMAPP class II fumarate decarboxylase/ kynureninase: 6 his sseA a tRNA Phe N -octanoyl-L-lysine a halide anion hydratase: fumC hydroxybutanoyl-CoA agmatinase pathway) kynU arginyl-[protein] L-cysteine in tRNA hydroxy fatty acid fumarate cis-aconitate arg L-homocysteine aconitate hydratase anthranilate AcnA: acnA hydrogen sulfide pyruvate L-glutamine pyruvate Cofactor, Carrier, and Vitamin Biosynthesis an (R)-2- guanine 37 1498 degradation I an N-terminal an L-phenylalanyl- coenzyme A [EntF L-seryl- a protein with glutathione pheophytin a a uracil roseoflavin DNA with lesion β-zeacarotene acetoacetyl-CoA agmatine Phe Hyp L-lysyl-[protein] [tRNA Phe ] carrier protein] a disulfide bond halocarboxylate in tRNA in 16S rRNA L-glutamine L-asparagine tRNA 16S rRNA bifunctional excinuclease lycopene cob(II)yrinate a,c- [2Fe-2S] iron-sulfur degradation II agmatinase: degradation I L-glutamate gln 4-hydroxyproline riboflavin kinase/ cob(II)yrinate a,c-diamide ubiquinol-8 biosynthesis flavin biosynthesis I (bacteria and plants) thiamine diphosphate NAD salvage superpathway of adenosylcobalamin salvage from cobinamide I thiamine diphosphate dipyrromethane succinate D-threo-isocitrate acetyl-CoA C- (guanosine(37)-N1) (uracil(1498)-N(3))- ABC subunit beta- diamide biosynthesis I cluster biosynthesis adenosylcobalamin NADP-dependent speB degradation I glutamate holo-ACP HAD family epimerase: FAD synthetase: biosynthesis II (late (early decarboxylation) biosynthesis II (Bacillus) pathway III (to biosynthesis III cofactor biosynthesis acetyltransferase: leucyl/phenylalanyl- chlorophyllase: -methyltransferase methyltransferase: UvrB: uvrB cyclase (early cobalt insertion) salvage from cobalamin (Staphylococcus) isocitrate dehydrogenase: AUL35_RS00975 synthase: synthase: glutaredoxin hydrolase: AUL35_RS10230 AUL35_RS06710 cobalt incorporation) all-trans- 2-(2-carboxy-4- nicotinamide riboside) cob(II)inamide ADP-forming succinate- gln agmatinase: asn tRNA--protein AUL35_RS13650 1 TrmD: trmD 3 AUL35_RS06810 [+ 2 isozymes] CrtY: crtY 2-(2-carboxy-4- an apo-[hydroxymethylbilane AUL35_RS01760 gltD gltB AUL35_RS17240 an N - an N - roseoflavin DNA without 7,8-dihydro- uroporphyrinogen-III L-cysteine desulfurase -CoA ligase: sucC sucD [+ 2 isozymes] glutamate speB glu transferase: AUL35_RS15650 3: grxC 37 1498 (4R)-4-hydroxy- octaprenyl GTP methylthiazol-5- + methylguanine methyluracil uroporphyrinogen-III uroporphyrinogen-III 4-hydroxybenzoate HMP-PP NADP cob(I)yrinic acid a,c-diamide cob(I)alamin HMP-PP methylthiazol-5- synthase]-L-cysteine synthase: asparaginase: [+ 5 isozymes] [+ 4 isozymes] D-proline 5'-phosphate lesion β-carotene diphosphate yl)ethyl phosphate NAD-glutamate AUL35_RS14430 Phe uroporphyrinogen-III yl)ethyl phosphate acetyl-CoA putrescine AUL35_RS08980 glu a holo-[EntF in tRNA in 16S rRNA C-methyltransferase: cysteine adenosyltransferase: gltD gltB dehydrogenase: a protein with pheophorbide a phytol C-methyltransferase: GTP succinyl-CoA 2-oxoglutarate asp cobA desulfurase: 4-hydroxybenzoate AUL35_RS16420 a [hydroxymethylbilane glu AUL35_RS12805 3',5'-ADP L-seryl-carrier GSSG cobA cyclohydrolase thiamine L-phenylalanyl- reduced L- a (2R)-2- precorrin-1 sufS NAD + cob(II)alamin thiamine synthase] ES intermediate 2-oxoglutarate a tRNA Phe protein] a halide anion octaprenyltransferase: cob(I)yrinic acid a,c-diamide 2 L-lysyl-[protein] hydroxy fatty acid precorrin-1 II RibA: ribA phosphate phosphate cysteine residues AUL35_RS01535 2,5-diamino-6- adenosyltransferase: cobO uroporphyrinogen-III an S-sulfanyl-[L- synthase: NAD(+) cob(I)yrinic acid synthase: hydroxymethylbilane uroporphyrinogen-III (5-phospho-D- 2-oxoglutarate C-methyltransferase: cysteine desulfurase] AUL35_RS18765 diphosphatase: a,c-diamide AUL35_RS18765 synthase: hemC C-methyltransferase: 4-hydroxy-3- ribosylamino) [corrinoid adenosyltranferase]-cob(II)inamide dehydrogenase an sn-glycero-3- cobA 5-methoxy-6- 37 UDP a carotenoid thiamine nudC adenosyltransferase: a [hydroxymethylbilane [EntB aryl- an L-arginyl- a guanine acetoacetyl-CoA D-glyceraldehyde cobA octaprenylbenzoate pyrimidin- thiamine E1 component: NaMN coenzyme A a protein phospho-N-(acyl) a chlorophyll Ins(2)P phosphate AUL35_RS16420 synthase] ES intermediate methylbenzimidazole carrier protein] [tRNA Arg ] in tRNA vitamin B12- ψ-end group precorrin-2 4(3H)-one phosphate 3 AUL35_RS12855 ethanolamine tRNA 3-hydroxybutyryl- aldehyde lycopene synthase: NMN cob(I)yrinic acid inositol dependent precorrin-2 an S-sulfanyl-[cysteine bifunctional synthase: hydroxymethylbilane (guanosine(37)-N1) CoA dehydrogenase beta- AUL35_RS03450 a,c-diamide nicotinate-nucleotide-- monophosphatase: ribonucleotide desulfurase]-[disordered- diaminohydroxyphosphoribosylaminopyrimidine multifunctional 2',3'- AUL35_RS03450 synthase: hemC holo-ACP chlorophyllase: -methyltransferase dehydrogenase: iron-sulfur cyclase precorrin-2 C(20)- [corrinoid adenosyltranferase]-cob(I)inamide adenosyltransferase: dimethylbenzimidazole glycerophosphodiester AUL35_RS09475 reductase: form scaffold deaminase/5-amino-6-(5-phosphoribosylamino) cyclic-nucleotide 2'- synthase: arginyltransferase: AUL35_RS13650 TrmD: trmD AUL35_RS16405 subunit: paoA CrtY: crtY methyltransferase: 2-octaprenylphenol a [hydroxymethylbilane Secondary Metabolite Degradation phosphodiesterase: an N 1 - (S)-3- [+ 2 isozymes] AUL35_RS00615 protein] complex uracil reductase RibD: ribD thiamine phosphodiesterase/ cobO thiamine phosphoribosyltransferase: AUL35_RS15650 AUL35_RS00810 a carotenoid cobI cob(I)yrinic acid a,c-diamide synthase] ES intermediate AUL35_RS00435 37 D-glycerate sirohydrochlorin phosphate cob(II)alamin- 4 Respiration cobT methylguanine hydroxybutanoyl- myo-inositol β 2-polyprenylphenol 5-amino-6-(5- 5'-nucleotidase/ adenosyltransferase: phosphate dUDP -end group phospho-D- [corrinoid hydroxymethylbilane anhydromuropeptides recycling I in tRNA CoA precorrin-3A 6-hydroxylase: ubiB 3'-nucleotidase: AUL35_RS16420 myo-inositol degradation I D-threitol a holo-[EntB aryl- a chlorophyllide phytol ribosylamino)uracil adenosyltranferase] synthase: hemC 2-oxoglutarate decarboxylation to succinyl-CoA 5-methoxy-6- 3',5'-ADP an N-terminal an N- AUL35_RS11190 degradation a tRNA Arg sn-glycerol a [cysteine desulfurase]- 3-(all-trans cob(I)yrinic acid a,c-diamide GlcNAc-1,6- nicotinate carrier protein] arginyl-[protein] D-ribulose bifunctional 1-(β-D a holo-[hydroxymethylbilane methylbenzimidazole 3-phosphate acylethanolamine S-sulfanyl-[disordered- -octaprenyl) adenosyltransferase: cobO a [2-oxoglutarate anhMurNAc- cobalt- 5-phosphate diaminohydroxyphosphoribosylaminopyrimidine thiamine myo-inositol D-threitol ribotide phosphate benzene-1,2-diol ribofuranosyl) thiamine synthase] L-Ala-γ-D-Glu- form scaffold deaminase/5-amino-6-(5-phosphoribosylamino) diphosphate dehydrogenase D-threitol sirohydrochlorin bifunctional 2- 3,4- nicotinamide adenosylcobinamide cob(I)alamin- 6 DAP-D-Ala inositol 2- protein] complex E2 protein] N 2-oxoglutarate dehydrogenase: precorrin-3B cysteine polyprenyl-6- dihydroxy-2- uracil reductase RibD: ribD [corrinoid thiamine dehydrogenase: RNase III mRNA a 5,6- 5-amino-6-(5- bifunctional -lipoyl-L-lysine AUL35_RS11835 3-aci- a 2-(all-trans- dCDP adenosyltranferase] diphosphokinase: dehydrogenase 5-methoxybenzimidazole NaMN methyl red pheophytin b 20 D-ribofuranose rhodopin precorrin-3B C(17)- desulfurase: hydroxyphenol butanone-4- phospho-D- iolG nitropropanoate processing polyprenyl)phenol dihydrouracil Ins(1)P adenosylcobinamide cob(I)yrinic acid AUL35_RS19365 2-oxoglutarate E1 component: D-erythrulose ribokinase: vitamin B12- methyltransferase: sufS methylase/3- phosphate substrate in tRNA lycopene ribitylamino)uracil kinase/adenosylcobinamide- molybdenum cofactor biosynthesis dehydrogenase AUL35_RS12855 tRNA inositol dependent cobalt-factor III an S-sulfanyl-[cysteine demethylubiquinol 3- synthase: a,c-diamide N-acetyl-β-D- L-alanyl-γ-D- scyllo-inosose 2-polyprenylphenol AUL35_RS13085 beta- cobJ phosphate thiamine E1 component: nicotinate-nucleotide-- nitronate FMN-dependent dihydrouridine(20/ monophosphatase: ribonucleotide desulfurase]-S- O-methyltransferase ribB superpathway of pyridoxal 5'-phosphate biosynthesis and salvage adenosyltransferase: glucosamine-1,6- glutamyl-meso-2,6- chlorophyllase: 6-hydroxylase: ubiB ribokinase: cyclase guanylyltransferase: cobU diphosphate molybdate AUL35_RS12855 myo-inosose-2 dimethylbenzimidazole monooxygenase: ribonuclease III: NADH- 20a) synthase AUL35_RS09475 reductase: precorrin-4 sulfanyl-[disordered- UbiG: ubiG 1-deoxy-L- AUL35_RS16420 anhydro-N-acetyl- diaminopimeloyl- D-sorbitol degradation I AUL35_RS13650 a 3-(all-trans AUL35_RS04185 CrtY: crtY D-erythrose [+ 2 isozymes] dehydratase: iolE D-erythrulose phosphoribosyltransferase: AUL35_RS10680 AUL35_RS15640 azoreductase: DusA: dusA [+ 2 isozymes] AUL35_RS00615 form scaffold 2-methoxy- glycero-tetrulose cob(I)yrinic acid a [2-oxoglutarate a [2-oxoglutarate β-D-muramate D-alanine -polyprenyl) D-ribofuranose 1'-hydroxy- precorrin-4 C(11)- ARP 4-phosphate adenosyl-cobinamide phosphate molybdenum 3D-(3,5/4)- 4-phosphate cobT AUL35_RS14920 a uracil 20 in tRNA myo-inositol protein] complex 6-(all-trans- 4-phosphate a,c-diamide molybdopterin dehydrogenase dehydrogenase beta-N- D-sorbitol benzene-1,2-diol 5-phosphate CDP γ-carotene methyltransferase: 5,6-dimethylbenzimidazole ABC 6 6 trihydroxycyclohexane- cobalt-precorrin-3 octaprenyl)phenol D-erythrose- adenosyltransferase: E2 protein] N E2 protein] N -S- acetylhexosaminidase: L-iditol 2- [unspecified bifunctional transporter 3-oxopropanoate RNase III pheophorbide b phytol cobM -dihydrolipoyl- succinyldihydrolipoyl- 1,2-dione nitrite degradation an mRNA fragment 6,7-dimethyl-8- 4-phosphate nicotinate-nucleotide-- adenosylcobinamide cobO ATP-binding AUL35_RS03310 L-alanyl-γ-D- dehydrogenase: 5-methoxybenzimidazole processing N,N-dimethyl-1,4- adenosylcob(III) L-lysine L-lysine 3D-(3,5/4)- D-erythrose nicotinate products] anthranilate precorrin-5 a [cysteine ribityllumazine dehydrogenase: dimethylbenzimidazole kinase/adenosylcobinamide- protein: modC beta-N- glutamyl-meso- AUL35_RS07125 ribotide phosphate product mRNA phenylenediamine alamin-[corrinoid molybdopterin trihydroxycyclohexane- 4-phosphate keto-D-fructose desulfurase]-(S- 2-methoxy-6-all synthase: gap phosphoribosyltransferase: phosphate acetylhexosaminidase: diaminopimelate sulfanyl) -[disordered- AUL35_RS00760 4-phospho- cobT adenosyltranferase] molybdate adenine 1,2-dione acylhydrolase 2 trans-octaprenyl- guanylyltransferase: cobU nagZ cobalt-precorrin-4 dinucleotide (decyclizing): iolD Alcohol Degradation form scaffold 1,4-benzoquinol D-erythronate cob(I)yrinic acid 2-oxoglutarate a DNA containing 1,6-anhydro-N- 5-hydroxybenzimidazole NaMN a sialyloligosaccharide 3-aminopropanal δ protein] complex 6,7-dimethyl-8-(1- α-ribazole 5'-phosphate adenosylcobinamide-GDP a,c-diamide dehydrogenase hydrogen selenide O-acetyl-L-serine an apurinic/ canavaninosuccinate trans-aconitate (S)-5-hydroxyisourate D-glycerate an aldehyde -carotene bifunctional molybdopterin acetyl-β-muramate 5-deoxy-D-glucuronate precorrin-6A demethylmenaquinone D-ribityl)lumazine adenosyltransferase: E1 component: β-D-fructofuranose glycerol and glycerophosphodiester degradation apyrimidinic site trans-aconitate 2- betaine-aldehyde 2-hydroxy-3- zinc-binding lycopene molybdotransferase anhydro-N- ethanol glycerol degradation V hydroxyisourate methyltransferase/2- AUL35_RS16420 AUL35_RS12855 5-deoxy- methyltransferase: dehydrogenase: oxopropionate alcohol beta- cobalt- riboflavin synthase: (3R)-3-hydroxy-2-oxo- adenosylcobinamide-GDP MoeA: acetylmuramic degradation II nicotinate-nucleotide-- exo-alpha-sialidase: hydrolase: uraH superpathway of β-D- glucuronate glycerol cysteine argininosuccinate betB reductase: dehydrogenase: cyclase methoxy-6-polyprenyl- AUL35_RS00765 4 phosphooxybutanoate ribazoletransferase: cobS cob(I)yrinic acid 2-oxoglutarate dimethylbenzimidazole AUL35_RS12170 endonuclease AUL35_RS16375 precorrin-5A a [cysteine desulfurase]- AUL35_RS00335 acid kinase: glycerol synthase lyase: argH (E)-3- (S)-2-oxo-4- AUL35_RS14725 AUL35_RS07510 CrtY: crtY 1,4-benzoquinol a,c-diamide dehydrogenase glucuronosides degradation isomerase: iolB ethanol III: nth [scaffold protein- phosphoserine AUL35_RS04160 phosphoribosyltransferase: exo-alpha-sialidase: A: cysK β-alanine tartronate methylase UbiE: ubiE riboflavin adenosyltransferase: MoO - complex 5-dehydro-2- alcohol [+ 2 isozymes] (methoxycarbonyl) hydroxy-4-carboxy- an alcohol α-carotene precorrin-6B (2Fe-2S)] complex 2 N-acetyl-D- F6P cobT AUL35_RS12175 transaminase: adenosylcobalamin 5'-phosphate a β-D-glucuronoside pent-2-enedioate 5-ureidoimidazoline semialdehyde 6-methoxy-3- cobO molybdopterin dihydrolipoyllysine- muramate 6- deoxy-D-gluconate a glycerophosphodiester dehydrogenase bifunctional AUL35_RS03995 dihydroxyacetone L-canavanine fumarate cobalt- methyl-2-all- cofactor residue phosphate 5-dehydro-2- glycerol AdhP: adhP acetate riboflavin kinase/ 4-phosphooxy- adenosylcobalamin L-selenocysteine a 3'-terminal a 5'-phospho- precorrin-5B trans-octaprenyl- succinyltransferase: N-acetylmuramic deoxygluconokinase: acetaldehyde dihydroxyacetone 5-hydroxybenzimidazole nicotinate N-acetylneuraminate an oligosaccharide a [co-chaperone]- FAD synthetase: L-threonine coenzyme A biosynthesis glycerophosphodiester unsaturated sugar [DNA] cobalt-precorrin- 1,4-benzoquinol odhB acid 6-phosphate iolC kinase subunit ribotide phosphate [scaffold protein- AUL35_RS06710 4-hydroxythreonine- I (prokaryotic) phosphodiesterase: glycerol kinase 5B (C(1))- precorrin-7 etherase: D-glucopyranuronate 5-dehydro-2-deoxy-D- DhaK: dhaK (2Fe-2S)] complex 4-phosphate adenosylcobalamin AUL35_RS00435 GlpK: glpK methyltransferase: FMN (R)-4'- AUL35_RS18925 gluconate 6-phosphate D-glyceraldehyde UDP-N-acetyl- decaprenyl-diphospho-N- a 3,5,7,9,11,13,15- 6-O-α-mycolyl- pyruvate dehydrogenase phosphopantothenate N-acetyl-D- DHAP a negatively AUL35_RS08495 3-phosphate thiazole component of thiamine diphosphate biosynthesis II α acetylmuramoyl-pentapeptide glutathione coenzyme A VibB glycerophosphoserine hepta-oxo- β-carotene a dipeptide D-glycerate an aldehyde 3-demethylubiquinol-8 bifunctional PdxA: bifunctional glucosamine acetate -D-glucosamine hypoglycin A supercoiled DNA trehalose 6- cobalt- 2-oxoisovalerate decarboxylation to isobutanoyl-CoA sn-glycerol 3-phosphate hexadecanoyl-[PKS-acp] DNA 2-hydroxy-3- aldehyde riboflavin kinase/ AUL35_RS04390 phosphopantothenoylcysteine 6-phosphate aldo/keto beta-carotene membrane phosphate precorrin-6A a [chaperone-ATP]- 1-deoxy-D-xylulose- aldehydo-D-glucuronate trehalose- precorrin-8x bifunctional 2- FAD synthetase: decarboxylase/ cys a [ThiS sulfur- acetate--CoA undecaprenyldiphospho- reductase: 15,15'-dioxygenase, topoisomerase dipeptidase: oxopropionate dehydrogenase [co-chaperone]- 4-hydroxythreonine- an [apo BCAA N-acetylglucosamine- glycerol-3-phosphate glycerophosphodiester phosphatase: cobalt-precorrin- polyprenyl-6- 5-phosphate phosphopantothenate-- carrier protein] ligase: acs muramoylpentapeptide beta-N- holo-ACP Brp/Blh family: IV subunit B: parE AUL35_RS05185 reductase: iron-sulfur [scaffold protein- AUL35_RS06710 4-phosphate dehydrogenase 6-phosphate glucuronate DHAP 3-oxopropanoate dehydrogenase: phosphodiesterase: AUL35_RS09870 6A reductase: precorrin-8X hydroxyphenol synthase: cysteine ligase CoaBC: coaBC gamma- synthase: AUL35_RS21685 AUL35_RS14725 subunit: paoA otsB (R)-4'- cysteine 6 deacetylase: nagA isomerase: acetylglucosaminyltransferase: [+ 14 isozymes] [+ 2 isozymes] methylmutase: (2Fe-2S)] complex AUL35_RS01495 dehydrogenase E2 protein] N alpha-ketoacid AUL35_RS18250 acetyl-CoA glutamyltransferase: ggt AUL35_RS00435 9-hydroxy-3,5,7,11,13,15- a proteinogenic tartronate α, α'-trehalose AUL35_RS08500 methylase/3- FAD phosphopantothenoyl- desulfurase: uxaC murG AUL35_RS15650 all-trans-retinal a relaxed DNA a carboxylate AUL35_RS08525 PdxA: pdxA -lipoyl-L-lysine dehydrogenase D-glucosamine glycerol-3-phosphate hexaoxohexadecanoyl- amino acid semialdehyde 6-α-mycolate cobalt- demethylubiquinol 3- L-cysteine sufS 1-deoxy-D- 3-amino-1- dihydrolipoyl subunit beta: 6-phosphate dehydrogenase: [PKS-acp] precorrin-6B O-methyltransferase bifunctional an [L-cysteine a carboxy- D-fructuronate sn-glycerol hydrogenobyrinate xylulose 5- hydroxyacetone dehydrogenase: AUL35_RS04520 phosphoglucosamine AUL35_RS09405 decaprenyl-pyrophosphoryl- UDP 3',5'-ADP a holo-[VibB aryl- ser UbiG: ubiG phosphopantothenoylcysteine desulfurase]-S- adenylated-[ThiS acetyl-CoA hypoglycin B L-cysteinylglycine 3-phosphate a [chaperone- phosphate 1-phosphate pyridoxine lpdA mutase: (N-acetylglucosamine)-N- carrier protein] an [2Fe-2S] decarboxylase/ D-glyceraldehyde sulfanyl-L-cysteine sulfur-carrier protein] ADP]-[disordered- dihydrolipoyl AUL35_RS03980 DHAP acetylmuramyl-(pentapeptide) cluster protein ubiquinol-8 tetrahydrofolate biosynthesis pyridoxamine 3-phosphate D-galactonate degradation form scaffold pyridoxine 5'- phosphopantothenate-- pyridoxal cysteine gly dehydrogenase: α-D-glucosamine cobalt-precorrin-7 protein] complex phosphate cysteine ligase CoaBC: coaBC 1-deoxy-D-xylulose- an [apo BCAA D-mannonate (7,8-dihydropterin- AUL35_RS12880 1-phosphate 10 a 2,3,4-saturated hydrogenobyrinate kinase pyridoxal desulfurase: an [apo BCAA dehydrogenase D-galactonate an L-methionyl- an N - an N-terminal L- an L-arginyl- D-arabinofuranose a [protein]-L- 6-yl)methyl synthase: 5-phosphate dehydrogenase 6 glycerophosphoglycerol hydantoin a uridine in tRNA acetaldehyde butan-1-ol citrate a,c-diamide kinase sufS Met Arg 1,2-diacyl-sn- ω 4-aminobenzoate PdxY: 4'-phosphopantetheine 6 E2 protein] N -S-[2- mannonate D-galacturonate formyltetrahydrofolate glutamyl-[protein] 5-phosphate proline ( = 180) bifunctional cobalt- AUL35_RS01975 synthase: E2 protein] N bifunctional UDP-N- [initiator tRNA ] [tRNA ] CTP diphosphate pdxY PdxY: methylpropanoyl]dihydrolipoyl- galactonate Detoxification glycerol 3-phosphate dihydropyrimidinase: 3-deoxy-8- tRNA peptidylprolyl aldehyde zinc-binding aconitate precorrin-7 (C(5))- cobaltochelatase: AUL35_RS01495 -dihydrolipoyl- acetylglucosamine dehydratase: degradation I an [Fe-S cluster pdxY pantetheine- a thiocarboxylated- L-lysine dehydratase: hydA phosphooctulonate dihydrouridine isomerase: dehydrogenase alcohol methyltransferase/ cobS cobT dihydropteroate L-lysine diphosphorylase/ uxuA glycerophosphodiester hydratase phosphate 1-deoxy-D-xylulose [ThiS sulfur- aldehydo-D- dihydropyrimidinase: synthase DusB: AUL35_RS16165 (NADP(+)): dehydrogenase: cobalt-precorrin- cobaltochelatase biosynthesis 2-iminoacetate glucosamine-1- dgoD reactive oxygen species degradation methionyl-tRNA arginyltransferase: phosphatidate synthase: kdsA AcnA: acnA synthase: folP pyridoxine pyridoxamine 5-phosphate carrier protein] mannonate galacturonate phosphodiesterase: subunit CobN: cobN chaperone]-ATP adenylyltransferase: glucuronate arsenate arsenate formyltransferase: AUL35_RS00810 cytidylyltransferase: hydA AUL35_RS00225 [+ 4 isozymes] AUL35_RS05250 AUL35_RS07510 6B (C(15))- 5'-phosphate 5'-phosphate phosphate N- dehydratase: 2-dehydro-3-deoxy- AUL35_RS00435 KDO-8P a 5,6-dihydrouridine a [protein]-L- D-threo-isocitrate coaD isomerase: detoxification detoxification AUL35_RS13640 AUL35_RS00395 acetate 1-butanal methyltransferase: cob(II)yrinate 7,8- phosphopantothenate biosynthesis I acetyltransferase uxuA D-galactonate N-carbamoylglycine proline (ω = 0) 3'-dephospho- thiazole synthase: uxaC superoxide III (thioredoxin) in tRNA AUL35_RS08520 a,c-diamide GlmU: glmU 2-dehydro-3- II (glutaredoxin) an N-terminal dihydropteroate pyridoxamine pyridoxamine AUL35_RS03445 2-dehydro-3- D-tagaturonate pyridoxal CoA α superoxide dismutase: arsenate an N-formyl- a tRNA Arg L-arginiyl-L- glycerol sn-glycerol bifunctional 3-methyl-2-oxobutanoate 5-phosphate 5-phosphate N-acetyl- -D- deoxy-D-gluconate deoxygalactonokinase: arsenate a CDP-2,3,4-saturated- cobalt-precorrin-8 thiazole component of thiamine diphosphate biosynthesis I dephospho- 2-methyladeninyl adenosylcobamide AUL35_RS09015 arsenate reductase L-methionyl- a tetrahydrofolate glutamyl-[protein] 3-phosphate folylpolyglutamate oxidase: oxidase: 2-[(2R,5Z)-2-carboxy- glucosamine tagaturonate AUL35_RS10425 arsenate diacylglycerol 3-methyl-2-oxobutanoate CoA kinase: 4-methylthiazol-5(2H)- biosynthesis from adenosylcobinamide-GDP 2-dehydro-3-deoxy- superoxide dismutase: (glutaredoxin): arsC [initiator tRNA met ] synthase/ AUL35_RS07925 AUL35_RS07925 pyridoxal 1-phosphate reductase: reductase hydroxymethyltransferase: AUL35_RS12590 ylidene]ethyl phosphate D-galactonate AUL35_RS03125 cys dihydrofolate pyridoxamine pyridoxamine kinase bifunctional UDP-N- AUL35_RS07585 (glutaredoxin) arsenate reductase AUL35_RS07715 2-methyladenine 6-phosphate 5'-phosphate 5'-phosphate : arsC (glutaredoxin): arsC a [glycine-cleavage 1402 dimethyl(3- synthase: PdxY: coenzyme A acetylglucosamine KDGP D-altronate hydrogen peroxide an N-terminal L- an L-arginyl- a single- sn-glycero-3- a cytidine L-malic 3-methyl-2-oxobutanoate arsenite complex H protein] uroporphyrinogen-I chloroacetaldehyde D-glycerate oxopropyl) 7,8-dihydropterin cobyrinate cysteine AUL35_RS10995 oxidase: pdxH oxidase: pdxH pdxY nicotinate-nucleotide-- diphosphorylase/ [+ 2 isozymes] a sulfurated [sulfur carrier] SAM aspartyl-[protein] Arg stranded RNA phosphoethanolamine in 16S rRNA semialdehyde 2-dehydro-3-deoxy-6- 6 [tRNA ] desulfurase: hydroxymethyltransferase: 2-(2-carboxy-4- glucosamine-1- altronate arsenite N -octanoyl-L-lysine 16S rRNA aldehyde glyoxylate/ aldehyde sulfanium 7,8-dihydrofolate dimethylbenzimidazole phosphogalactonate uroporphyrinogen guanine panB adeninyl adenosylcobamide biosynthesis methylthiazol-5- dehydratase: catalase: (cytidine(1402)-2'-O) dehydrogenase hydroxypyruvate dehydrogenase betaine-aldehyde sufS monoglutamate phosphoribosyltransferase: phosphate N- 2-dehydro-3-deoxy- decarboxylase: deaminase: an [L-cysteine from adenosylcobinamide-GDP aldolase: glycerophosphodiester dehydrogenase: PLP yl)ethyl phosphate cobT acetyltransferase phosphogluconate AUL35_RS15465 AUL35_RS01700 arginyltransferase: polyribonucleotide -methyltransferase: AUL35_RS12605 (NADP(+)): reductase A: (NADP(+)): guaD desulfurase]-S- a [ThiS sulfur- 2-dehydropantoate AUL35_RS10420 lipoyl phosphodiesterase: betB benzimidazolyl adenosylcobamide GlmU: glmU aldolase: altronate [+ 2 isozymes] AUL35_RS00810 nucleotidyltransferase: pnp a 2'-O- rsmI AUL35_RS05250 AUL35_RS17500 AUL35_RS05250 7,8- cob(II)yrinate sulfanyl-L-cysteine carrier protein] H O hydroxyl radical arsenite synthase: lipA AUL35_RS00435 coproporphyrinogen I biosynthesis from adenosylcobinamide-GDP 2-methyladenine UDP-N-acetyl- AUL35_RS08800 dehydratase: 2 1402 2-chloroacetate hydroxypyruvate (S)-malate DMSP dihydrolumazine a,c-diamide cysteine adenine D-glyceraldehyde arsenite methylcytidine adenosylcobinamide- ribotide phosphate α-D-glucosamine AUL35_RS12145 pyruvate desulfurase: a 7,8-dihydrofolate 3-phosphate O an N-terminal a single- in 16S rRNA benzimidazole D-glyceraldehyde 2 a [glycine-cleavage a nucleoside nicotinate-nucleotide-- GDP UDP-N-acetylglucosamine 2-dehydro- a tRNA Arg L-arginiyl-L- ethanolamine sn-glycerol sufS β pyruvate 5'-deoxyadenosine 6 an unsulfurated diphosphate stranded RNA dihydrofolate -alanine (R)-pantoate 1-carboxyvinyltransferase: 3-phosphate 3-deoxy-D- met complex H protein] N aspartyl-[protein] 3-phosphate a [ThiI sulfur- a carboxy- nicotinate-nucleotide-- dimethylbenzimidazole [sulfur carrier] D-glyceraldehyde reductase: adenosylcobinamide- murA gluconate -[(R)-lipoyl]-L-lysine thiamine diphosphate carrier protein]-S- adenylated-[ThiS dimethylbenzimidazole phosphoribosyltransferase: 3-phosphate AUL35_RS00900 GDP UDP-N-acetyl-α- biosynthesis I (E. coli) tyr sulfanyl-L-cysteine sulfur-carrier protein] pantoate--beta-alanine phosphoribosyltransferase: cobT 1-deoxy-D-xylulose- ribazoletransferase: D-glucosamine- 6-O-cis-keto- 2-[(2R,5Z)- a tetrahydrofolate ligase: AUL35_RS17340 cobT a [pyruvate dehydrogenase E2 RNase R degradation a cytidine 1402 5-phosphate adenine ribotide cobS enolpyruvate H + hydrogencarbonate coenzyme A 1-hydroxyneurosporene (E)-caffeoyl-CoA D-glycerate an aldehyde mycolyl-trehalose N-ethylmaleimide 2-carboxy-4- benzimidazole a sulfurated [sulfur carrier] SAM protein] N 6 -octanoyl-L-lysine substrate RNA in 16S rRNA synthase: adenosylcobinamide- phosphate KDGP adenosylcobinamide- ribotide UDP-N- 16S rRNA carotenoid electron transfer glyoxylate/ aldehyde 6-phosphate alkene methylthiazol-5(2H (R)-pantothenate GDP Coα-[α-(2- trehalose- AUL35_RS01495 a thiocarboxylated- GDP phosphate acetylmuramate (cytosine(1402)-N(4) flavoprotein hydroxypyruvate dehydrogenase )-ylidene]ethyl methyladenin-9-yl)]-Co carbonic 1,2-hydratase: reductase: HMP-PP 1-deoxy-D-xylulose [ThiS sulfur- dehydrogenase: 2-dehydro-3-deoxy- ribonuclease CoA pyrophosphatase: )-methyltransferase subunit alpha: reductase A: (NADP(+)): phosphatase: phosphate 2-iminoacetate type I pantothenate β-adenosylcobamide anhydrase: AUL35_RS13590 nemA 5-phosphate carrier protein] adenosylcobinamide- murB phosphogluconate R: rnr AUL35_RS04985 RsmH: rsmH AUL35_RS16410 AUL35_RS17500 AUL35_RS05250 otsB adenosylcobinamide- lipoyl synthase: lipA an N 4 - 1,1'-dihydroxy- kinase: AUL35_RS12450 GDP 5'-phosphate aldolase: AUL35_RS12825 trehalose-cis-keto- N-ethylsuccinimide GDP UDP-N-acetyl- 1402 a carboxylate thiamine methylcytidine neurosporene hydrocaffeoyl-CoA hydroxypyruvate mono-mycolate thiazole synthase: bis(guanylyl molybdopterin) ribazoletransferase: α AUL35_RS08800 phosphate (R)-4'-phosphopantothenate ribazoletransferase: -D-muramate in 16S rRNA AUL35_RS03445 cofactor sulfurylation cobS a nucleoside 5'- synthase: cobS pyruvate a [pyruvate dehydrogenase CO H O a diribonucleotide 3',5'-ADP 4'-phosphopantetheine 5-methylbenzimidazolyl adenosylcobamide Coα-[α-(2- 5'-deoxyadenosine 2 2 monophosphate AUL35_RS18765 2-[(2R,5Z)-2-carboxy- Coα-[α-(adenin-9-yl)]- met E2 protein] N 6 -lipoyl-L-lysine an unsulfurated [sulfur carrier] biosynthesis from adenosylcobinamide-GDP folate transformations III (E. coli) Coα-[α- methyladenin-7-yl)]-Co 4-methylthiazol-5(2H)- cys Coβ-adenosylcobamide thiamine (benzimidazolyl)]-Co β-adenosylcobamide UDP-N-acetyl- Inorganic Nutrient Metabolism ylidene]ethyl phosphate phosphate 5-methylbenzimidazole β-adenosylcobamide 5'-phosphate α-D-muramoyl- a tetrahydrofolate cysteine molybdopterin biosynthesis synthase: L-alanyl-γ-D- 7,8-dihydrofolate adenine 2030 5'-phosphate desulfurase: (aminomethyl) a 5-L-glutamyl- NADPH H + phylloquinone NAD(P)H H + a ribonucleoside a single 1-hydroxyneurosporene α-D-lyxopyranose D-glycerate propanoyl-CoA 15-cis-phytoene AUL35_RS03450 nicotinate-nucleotide-- glutamyl-meso-2,6- glyphosate degradation III methylphosphonate assimilatory an amino acid monoglutamate in 23S rRNA D-cysteine sufS phosphonate degradation assimilatory [peptide] triphosphate stranded DNA D-lyxose/D- dimethylbenzimidazole methionine diaminopimelate degradation I sulfate reduction IV 23S rRNA carotenoid glyoxylate/ acryloyl-CoA phytoene dihydrofolate an [L-cysteine Coα-[α-(adenin-7-yl)]- sulfate reduction III mannose family D-cysteine thiamine phosphoribosyltransferase: synthase: ATP (adenine(2030)-N(6) 1,2-hydratase: hydroxypyruvate reductase: desaturase: reductase: Coα-[α- desulfurase]-S- Coβ-adenosylcobamide GTP (aminomethyl)phosphonate glyphosate dihydrofolate NAD(P)H:quinone sugar isomerase: desulfhydrase: metH methylphosphonate sulfate )-methyltransferase reductase A: phosphate cobT AUL35_RS00900 sulfanyl-L-cysteine cys phosphonate sulfate reductase: oxidoreductase: DNA primase: AUL35_RS13590 AUL35_RS08005 crtI (benzimidazolyl)]-Co bis(guanylyl sulfate gamma- RlmJ: rlmJ AUL35_RS06525 AUL35_RS17500 AUL35_RS07645 NAD salvage pathway I (PNC VI cycle) β cysteine molybdopterin- phosphonate sulfate wrbA AUL35_RS06180 an N 6 - all-trans 9,15,9'-tri-cis adenosylcobinamide- 5-methylbenzimidazole serine -adenosylcobamide molybdopterin) GTP 3',8- C-P lyase adenylyltransferase: glutamyltransferase: ggt AUL35_RS00900 D-xylulose acryloyl-CoA desulfurase: cysteine synthase C-P lyase adenylyltransferase: methyladenine 2030 neurosporene hydroxypyruvate pyruvate -ζ-carotene GDP ribotide phosphate a 7,8-dihydrofolatehydroxymethyltransferase:a 5-methyltetrahydrofolate cofactor cyclase (acetamidomethyl)phosphonate system protein cysD cysN sufS desulfurase: adenylyltransferase system protein cysD cysN in 23S rRNA NAD + AUL35_RS00780 MoaA: moaA PhnL: phnL APS α 5,6,7,8- a (6S)-5- a [bis(guanylyl sufS MoeB: moeB PhnL: phnL APS an -(5-L- + + ssDNA/pppN(pN) thiamine NAD(+) adenosylcobinamide- (8S)-3',8-cyclo-7,8- phosphonate C- α [+ 2 isozymes] NADP NAD(P) phylloquinol bifunctional formyltetrahydrofolate molybdopterin) an [L-cysteine a carboxy-adenylated -D-ribose-1-[N- α [+ 2 isozymes] glutamyl)- a peptide tetrahydrofolate hybrid diphosphate diphosphatase: nudC dihydroguanosine P lyase system -D-ribose-1- n -1 GDP methylenetetrahydrofolate 5-formyltetrahydrofolate cofactor [bis-MGD cofactor desulfurase]-S- [small subunit of (phosphonomethyl) adenylyl-sulfate phosphoadenylyl- amino acid 5'-triphosphate protein PhnL: phnL methylphosphonate- ribazoletransferase: thymidylate dehydrogenase/ cyclo-ligase: chaperone]-S- chaperone]- sulfanyl-L-cysteine molybdopterin synthase] glycine] 5-triphosphate kinase: cysC sulfate reductase: cyclic pyranopterin [+ 2 isozymes] 5-triphosphate NAD(+) synthase: cobS synthase: methylenetetrahydrofolate methenyltetrahydrofolate AUL35_RS03855 sulfanyl-L-cysteine bis-MGD alpha-D-ribose 1- AUL35_RS19920 monophosphate α-D-ribose 1- alpha-D-ribose 1- PAPS α undecaprenyl-diphospho-N 3 AUL35_RS09425 AUL35_RS00905reductase [NAD(P)H]: metF methylphosphonate UDP-N-acetyl- -D-glucosamine + an N -methyladenine an organic sn-glycerol 6,8- α α a 5,10- cyclohydrolase FolD: folD a 5,10- synthase (acetamidomethylphosphonate) methylphosphonate sulfite γ D-glucopyranose maltopentaose NAD(P)H a plastoquinone H a holo [PedN acyl- 2-chloroacetate pyruvate Co -[ -(5- 5-triphosphate -acetylmuramoyl-L-alanyl- - in DNA hydroperoxide 3-phosphate dihydroxypurine ser nicotinate adenine dinucleotide NMN methylenetetrahydrofolate methenyltetrahydrofolate MoaC: moaC 5-triphosphate 5-triphosphate phosphoadenylyl- carrier protein] methylbenzimidazolyl)]- diphosphatase: D-glutamyl-L-lysyl- D-alanine alkylhydroperoxidase L-glyceraldehyde haloacid xanthine pyruvate a thiocarboxylated diphosphatase: sulfate reductase: assimilatory sulfite ACP S- L-serine Coβ-adenosylcobamide bifunctional cyclic pyranopterin alpha-D-ribose 1- AUL35_RS03150 undecaprenyldiphospho- 4-alpha- domain protein: dehalogenase dehydrogenase: carboxylase: nicotinate-nucleotide sulfo-bis(guanylyl [small subunit of reductase (NADPH) NAD(P)H:quinone DNA-3- 3-phosphate 5'-phosphate methylenetetrahydrofolate menaquinol-7 biosynthesis methylphosphonate α-D-ribose-1-[N- AUL35_RS03150 AUL35_RS19920 malonyltransferase: type II: ammonia-lyase: folate polyglutamylation molybdopterin) molybdopterin synthase] phosphate α muramoylpentapeptide beta-N- glucanotransferase: oxidoreductase: methyladenine AUL35_RS06020 reductase: mgrA xdhA xdhB pyc adenylyltransferase: 5-triphosphate -D-ribose-1- : AUL35_RS19910 fabD AUL35_RS11785 AUL35_RS10255 dehydrogenase/ S-adenosyl-L- (phosphonomethyl) sulfite acetylglucosaminyltransferase: malQ a malonyl[PedN L-glyceraldehyde AUL35_RS21455 cofactor all-trans- hydroxymethylpyrimidine diphosphatase: methylphosphonate wrbA glycosylase I: tag an alcohol urate oxaloacetate methenyltetrahydrofolate methionine salvage II glycine] 5-phosphate hydrogen sulfide murG acyl-carrier 3-phosphate glycolate pyruvate a tetrahydrofolate heptaprenyl 1,4-dihydroxy- salvage AUL35_RS03150 5-phosphate α α cyclohydrolase FolD: folD alpha-D-ribose 1- NaMN nicotinamide Co -[ -(5- diphosphate 2-naphthoate α-D-ribose-1-(2-N- alpha-D-ribose 1- protein] 10 4-amino-2-methyl-5- methylphosphonate ditrans,octacis-undecaprenyldiphospho- maltose maltotetraose + an apurinic site methylbenzimidazolyl)]- an N - SAH acetamidomethylphosphonate) methylphosphonate UDP a plastoquinol NAD(P) 3-methyladenine β serine formate-- bifunctional molybdopterin pyrimidinemethanol 5-phosphate C- N-acetyl-(N-acetylglucosaminyl)muramoyl- within DNA Co -adenosylcobamide formyltetrahydrofolate adenosylhomocysteinase: bifunctional 5-phosphate 5-phosphate C- bifunctional hydroxymethyltransferase: tetrahydrofolate folylpolyglutamate P-lyase PhnJ: hydrogen sulfide L-alanyl-γ-D-glutamyl-L-lysyl-D-alanine AUL35_RS10960 hydroxymethylpyrimidine alpha-D-ribose 1- P-lyase PhnJ: nicotinate nicotinamidase/ AUL35_RS00780 ligase: synthase/ glutathione AUL35_RS03190 L-homocysteine kinase/ methylphosphonate 5- AUL35_RS03190 phosphoribosyltransferase: pyrazinamidase: pncA AUL35_RS04895 dihydrofolate biosynthesis demethylmenaquinol-7 α (2Z,4E)-2- phosphomethylpyrimidine phosphate C-P-lyase 5-phospho- -D-ribose UDP-N-acetyl-α-D-glucosamine undecaprenyl-diphospho-N-acetylmuramoyl-L- poly-3- S-(2-hydroxyacyl) (R)-3- phosphoenol pncB a 5,10- synthase: carbon-phosphorus D-glucopyranose maltohexaose L,L- 4-hydroxybenzoate ferroheme o a D-hexose PhnJ: AUL35_RS03190 1,2-cyclic phosphate alanyl-γ-D-glutamyl-L-lysyl- D-alanyl-D-alanine hydroxyoctanoate glutathione hydroxybutanoate hydroxyhexa- pyruvate 10 tetrahydrofolate salvage from thioredoxin kinase: thiD lyase complex diaminopimelate nicotinate methylenetetrahydrofolate an N - AUL35_RS10995 cys glu methionine bifunctional cytidylyl selenate reduction 2,4-dienedioate 5,10-methenyltetrahydrofolate HMP-P 4-hydroxybenzoate 3-hydroxybutyrate synthase: metH demethylmenaquinone molybdenum pathway carbon-phosphorus subunit PhnI: thiosulfate oxidation III (multienzyme complex) undecaprenyldiphospho- LL-diaminopimelate 4-oxalocrotonate heme A synthase: glucokinase: pyruvate bifunctional formyltetrahydrofolate 4-alpha- 3-monooxygenase: dehydrogenase: glutathione- methyltransferase/2- cofactor sulfurylation lyase complex subunit AUL35_RS03195 muramoylpentapeptide beta-N- aminotransferase: tautomerase: AUL35_RS03415 glutathione- folylpolyglutamate bifunctional a 5,10- bifunctional 5-phospho-α- polyhydroxyalkanoate hydroxyacylglutathione AUL35_RS08635 AUL35_RS00685 kinase: pyk peroxide a tetrahydrofolate cytidylyl molybdenum an oxidized PhnI: AUL35_RS03195 selenate acetylglucosaminyltransferase: glucanotransferase: pobA AUL35_RS12735 menaquinol-8 biosynthesis glutaredoxin glutamate-- methenyltetrahydrofolate met methoxy-6-polyprenyl- α-D-ribose 1,5- a [SoxY protein]-L-cysteine depolymerase: phaZ hydrolase: gloB AUL35_RS09660 synthase/ folylpolyglutamate bifunctional cofactor (trioxo) thioredoxin hydroxymethylpyrimidine D-ribose 1,2- sulfate murG malQ D-hexose 6- redox reactions redox reactions cysteine ligase: 1,4-benzoquinol 5-phospho-α-D-ribose (S)-2,3,4,5- protocatechuate acetoacetate (3E)-2-oxohex- ferroheme a pyruvate dihydrofolate synthase/ methylenetetrahydrofolate kinase/ bisphosphate cyclic phosphate adenylyltransferase: phosphate AUL35_RS06815 methionine methylase UbiE: ubiE 1,2-cyclic phosphate tetrahydrodipicolinate 3-enedioate demethylmenaquinol-8 GSSG glutathione synthase: dihydrofolate dehydrogenase/ phosphomethylpyrimidine cysD cysN adenosyltransferase: an [MCD cofactor ribose 1,5- adenosine 5'- ditrans,octacis-undecaprenyldiphospho-N- poly-3- poly-3- a 2-hydroxy bifunctional AUL35_RS10995 synthase: methenyltetrahydrofolate thioredoxin- kinase: thiD UDP maltopentaose maltose glutathione γ-L-glutamyl- AUL35_RS10735 menaquinol-7 chaperone]-MCD bisphosphate phosphoselenate acetyl-(N-acetyl-β-D-glucosaminyl)muramoyl-L- hydroxyoctanoate hydroxyoctanoate carboxylate demethylmenaquinone a 5,10- AUL35_RS10995 lipoate biosynthesis cyclohydrolase FolD: folD disulfide phosphokinase: a [SoxY protein]-S- L-cysteine an N 10 - cysteine HMP-PP α-D-ribose 1,5- alanyl-γ-D-glutamyl-L-lysyl-D-alanyl-D-alanine methyltransferase/2- glutathione- a reduced methylenetetrahydrofolate an N 10 - and incorporation I SAM reductase: phnN sulfosulfanyl-L-cysteine glutathione formyltetrahydrofolate desulfurase: methoxy-6-polyprenyl- disulfide glutaredoxin formyltetrahydrofolate trxB α-D-ribose 1,5-bisphosphate bisphosphate reductase: synthase: phosphoribosylglycinamide sufS PRPP cytochrome c: DNA combined with N,N'- 1,4-benzoquinol an octanoyl-[acp] D-glucopyranose a maltodextrin (2R,3S)-3- glutaredoxin gshB formyltransferase: a [cytidylyl molybdenum selenite AUL35_RS09020 a proteinogenic leukotriene-C4 2-nonaprenylphenol 2-hydroxyisobutyramide a folate ethanol γ-carotene D-glucopyranose methylase UbiE: ubiE gor menaquinol-6 biosynthesis thiamine ribose 1,5-bisphosphate exogenous DNA to form diacetylchitobiose isopropylmalate lipoyl(octanoyl) AUL35_RS02280 cofactor chaperone]- amino acid beta-N- 3: grxC a reduced [+ 2 isozymes] a recombinational junction dihydrofolate 3-isopropylmalate catalase: carotenoid xylose dimethylmenaquinone transferase glutathione diphosphate cytidylyl molybdenum phosphokinase: phnN Holliday junction a protein with menaquinol-9 biosynthesis thioredoxin acyl carrier NADP acetylhexosaminidase: 2-polyprenylphenol amidase: isomerase: methyltransferase: LipB: lipB a tetrahydrofolate demethylmenaquinol-6 salvage III a [SoxY protein]-S- a [SoxY protein]-S 4-alpha- resolvase RuvX: ruvX reductase: dehydrogenase: AUL35_RS01700 1,2-hydratase: reduced L- molybdenum a [lipoyl-carrier protein] cofactor (sulfo-dioxo) protein activation biosynthesis PRPP AUL35_RS03310 6-hydroxylase: ubiB AUL35_RS07300 xylA AUL35_RS19285 glutathione disulfanyl-L-cysteine -sulfanyl-L-cysteine glucanotransferase: crossover junction AUL35_RS00900 leuB [+ 2 isozymes] AUL35_RS13590 N 6 -octanoyl-L-lysine bifunctional thiamine diphosphate gamma- cysteine residues demethylmenaquinol-9 cofactor sulfulylation malQ beta-N- menaquinol-8 demethylmenaquinone thiamine NAD + selenodiglutathione glutamyltransferase: ggt endodeoxyribonuclease 3-(all-trans-nonaprenyl) 2-hydroxy-2- 4-methyl-2- 1'-hydroxy- keto-D-fructose (eukaryotes) lipoyl an apo acyl- acetylhexosaminidase: a 7,8-dihydrofolate acetaldehyde bifunctional MoO - methyltransferase/2- RuvC: ruvC benzene-1,2-diol methylpropanoate oxopentanoate γ-carotene 3 diphosphokinase: NAD kinase: RdgB/HAM1 family resolution of recombinational demethylmenaquinone synthase: lipA carrier proteinholo-ACP nagZ molybdopterin methoxy-6-polyprenyl- AUL35_RS19365 AUL35_RS18330 non-canonical junction formation N-acetyl-D- methyltransferase/2- a [lipoyl-carrier thiamine synthase: α γ a maltodextrin maltose cofactor molybdenum 1,4-benzoquinol + purine NTP an -( -L-glutamyl) of two intact strands 6 NADP diphosphate leukotriene-D4 glucosamine methoxy-6-polyprenyl- protein]-N -[(R)- methylase UbiE: ubiE diphosphate AUL35_RS15650 -L-amino acid cofactor sulfurase: a holo acyl- pyrophosphatase: a [SoxY protein]-S-(2- 1,4-benzoquinol Mo(O) (S)-AUL35_RS03500 dihydrolipoyl]-L-lysine menaquinol-6 glutathioselenol 2 carrier protein RdgB/HAM1 family non- rdgB sulfodisulfanyl)-L-cysteine methylase UbiE: ubiE molybdopterin canonical purine NTP inorganic a plant soluble 1518 55 menaquinol-9 cofactor a proteinogenic D-glucopyranose maltotriose a glucan adenine / a uridine a monocarboxylic pyrophosphatase: rdgB diphosphatase: glutathione heteroglycan 1519 2-decaprenylphenol hydroxypyruvate MeOH acetamide urea cycle amino acid adenine in 16S rRNA in tRNA acid amide inorganic AUL35_RS04720 16S rRNA tRNA catalase: 2-polyprenylphenol amidase: hydroxypyruvate amidase: diphosphatase: hydrogen selenide 4-alpha- 4-alpha- (adenine(1518)-N(6)/ pseudouridine(55) AUL35_RS01700 phosphate 6-hydroxylase: ubiB AUL35_RS07300 isomerase: hyi AUL35_RS07300 AUL35_RS04720 arg glucanotransferase: glucanotransferase: adenine(1519)-N(6))- synthase TruB: truB [+ 2 isozymes] gamma- dimethyltransferase malQ malQ 3-(all-trans-decaprenyl) a pseudouridine 55 tartronate phosphate sulfate activation glutamyltransferase: ggt RsmA: rsmA a monocarboxylate formaldehyde acetate ammonium N 6 -dimethyladenine 1518 benzene-1,2-diol in tRNA semialdehyde for sulfonation argininosuccinate a plant soluble /N 6 -dimethyladenine 1519 maltose a glucan D-glucopyranose lyase: argH glutamine- an α-(γ-L-glutamyl) in 16S rRNA polyphosphate metabolism L-cysteinylglycine heteroglycan sulfate hydrolyzing -L-amino acid sulfate carbamoyl- adenylyltransferase: L-arginino- long chain polyphosphate L-ornithine phosphate cysD cysN succinate an (S-diacyl-sn- a long-linear a (1->4)- synthase: an L-1- D-glucopyranose maltotetraose α-D-glucopyranose sucrose adenosyl-cob(III) ribulose cytidine APS glyceryl)-L-cysteinyl- α-D-glucan α uroporphyrinogen-III 4-guanidinobutyramide propionamide carA carB phosphatidylethanolamine -D-glucan yrinate a,c-diamide nucleoside [apolipoprotein] uroporphyrinogen-III cobyric acid deaminase: polyphosphate kinase: adenylyl-sulfate carbamoyl amidase: ribulokinase: amidase: 4-alpha- 4-alpha- C-methyltransferase: synthase: AUL35_RS16290 AUL35_RS00640 kinase: cysC phosphate amylosucrase: AUL35_RS07300 AUL35_RS02795 AUL35_RS07300 exopolyphosphatase: argininosuccinate ornithine apolipoprotein N- glucanotransferase: glucanotransferase: cobA AUL35_RS08570 RNA degradosome AUL35_RS17550 [+ 3 isozymes] AUL35_RS02255 synthase: carbamoyltransferase: L(or D)-ribulose PAPS acyltransferase: lnt malQ malQ polyphosphate kinase: AUL35_RS18575 argF precorrin-2 4-guanidinobutanoate adenosylcobyrate 5-phosphate propanoate uridine L-citrulline AUL35_RS02260 a (1->4)- a 2-acyl-1-lyso- an N-acyl-(S-diacyl- a short 1,4- D-fructofuranose maltose maltotriose α-D-glucan phosphatidylethanolamine sn-glyceryl)-L- α-D-glucan cysteinyl-[lipoprotein] long chain polyphosphate

2-amino-6-[1-hydroxyethyl]- a pseudouridine 1915 a 5' triphospho- CTP Carboxylate Degradation glycyl-glycine glutathione chlorobactene rhodopin 5,6-dihydrouracil L-fuconate methylglyoxal 7-methyl-7,8-dihydropterin in 23S rRNA [mRNA] 2'-deoxycytidine 23S rRNA 2-amino-4-hydroxy-6- RNA carotenoid carotenoid NAD-dependent L-fuconate glyoxalase: 5'-triphosphate propanoyl CoA hydroxymethyldihydropteridine (pseudouridine(1915)- pyrophosphohydrolase: 1,2-hydratase: 1,2-hydratase: dihydropyrimidine dehydratase: AUL35_RS18440 pyruvate fermentation pyruvate decarboxylation to acetyl CoA I superpathway of acetate deaminase: degradation I 3-oxoadipate gamma- N(3))-methyltransferase to acetate IV diphosphokinase: folK AUL35_RS02725 AUL35_RS13590 AUL35_RS13590 dehydrogenase AUL35_RS10460 [+ 3 isozymes] AUL35_RS15405 utilization and formation degradation glutamyltransferase: ggt [1-(2-amino-7-methyl-4-oxo- RlmH: rlmH a [pyruvate an N 3 - a 5'-phospho- 1,1'-dihydroxy-1,1',2,2'- subunit PreA: preA 2-dehydro-3- propanoyl-CoA 7,8-dihydro-3H-pteridin- 1-hydroxychlorobactene (R)-lactate UTP pyruvate dehydrogenase methylpseudouridine 1915 [mRNA] tetrahydrolycopene uracil deoxy-L-fuconate acyl-CoA acetate acetate- 3-oxoadipate 6-yl)]ethyl diphosphate E2 protein] N 6 pyruvate γ in 23S rRNA carboxylase -CoA 3-oxoacid CoA- -L-glutamyl- -lipoyl-L-lysine acetate/propionate L-cysteinylglycine subunit beta: pyruvate ligase: acs transferase: glycylglycine dihydrolipoyl family kinase: AUL35_RS06960 dehydrogenase: AUL35_RS20340 (S)-methylmalonyl- dehydrogenase: AUL35_RS02980 AUL35_RS00275 3-oxoacid CoA- 2,5-diamino-6-(5- 5,6- CoA lpdA 6-(hydroxymethyl) a 5-carboxymethylaminomethyluridine 34 α-L- dCTP acetyl-CoA formate pdhA transferase 2-heptaprenylphenol an α-limit dextrin 2-phosphoglycolate L-iditol acetyl phosphate acetyl-CoA phospho-D-ribitylamino) Leu dihydrothymine rhamnopyranose methylmalonyl- dihydrolipoyl -7,8-dihydropterin in tRNA 2'-deoxycytidine subunit A: pyrimidin-4(3H)-one tRNA (cytidine(34) NAD-dependent L-iditol 2- CoA epimerase: bifunctional enoyl- dehydrogenase: bifunctional 2-amino-4-hydroxy-6- 4-alpha- L-rhamnose 5'-triphosphate AUL35_RS05840 -2'-O)- 2-polyprenylphenol phosphoglycolate dihydropyrimidine dehydrogenase: AUL35_RS07420 CoA hydratase/ AUL35_RS12880 a [pyruvate diaminohydroxyphosphoribosylaminopyrimidine hydroxymethyldihydropteridine glucanotransferase: mutarotase: deaminase: a [pyruvate pyruvate 3-oxoadipyl-CoA methyltransferase: 6-hydroxylase: ubiB phosphatase: gph dehydrogenase phosphate dehydrogenase deaminase/5-amino-6-(5-phosphoribosylamino) diphosphokinase: folK malQ AUL35_RS04605 AUL35_RS07125 AUL35_RS15405 methylmalonyl- dehydrogenase dehydrogenase 6 α subunit PreA: preA β acetyltransferase: E2 protein] N -S- (7,8-dihydropterin- AUL35_RS05005 3-(all-trans-heptaprenyl) a -limit dextrin -L- CoA E2 protein] N 6 - complex bifunctional enoyl- 3-oxoadipyl-CoA uracil reductase RibD: ribD a 5-carboxymethylaminomethyl- glycolate keto-L-sorbose dUTP AUL35_RS02975 acetyldihydrolipoyl- 5-amino-6-(5-phospho- 6-yl)methyl benzene-1,2-diol with short branches thymine rhamnopyranose epimerase: mce dihydrolipoyl-L-lysinedihydrolipoamide CoA hydratase/ thiolase: pcaF 2'-O-methyluridine 34 in tRNA Leu L-lysine phosphate D-ribitylamino)uracil diphosphate (R)-methylmalonyl- acetyltransferase: acetyl phosphate glycolate and acetyltransferase: CoA AUL35_RS00265 acetyl-CoA glyoxylate AUL35_RS02975 methylmalonyl- acetate/propionate degradation II CoA family kinase: mutase: scpA AUL35_RS02980 glycolate acetyl-CoA glycolate succinyl-CoA acetate D-gluconate oxidase: glcF glcE degradation glyoxylate

D-gluconate malate synthase G: gluconokinase: AUL35_RS11185 AUL35_RS12615 D-gluconate (S)-malate 6-phosphate a reduced a reduced a reduced plastocyanin plastocyanin plastocyanin an oxidized an oxidized an oxidized phosphonate plastocyanin plastocyanin plastocyanin an (aminoalkyl)phosphonate phosphate thiamine molybdate D-ribopyranose D-ribopyranose L-arabinose L-arabinose queuosine ammonium an alkylphosphonate 3-O-L-lysyl-1-O- phosphatidylglycerol

cytochrome cytochrome cytochrome RS14850 RS10490 RS07155 AraH PhnC RS17895 RS18860 Amt MprF ThiQ ModC c oxidase c oxidase c oxidase

phosphonate D-ribopyranose D-ribopyranose L-arabinose L-arabinose thiamine molybdate an (aminoalkyl)phosphonate queuosine phosphate ammonium 3-O-L-lysyl-1-O- O O O an alkylphosphonate phosphatidylglycerol 2 2 2 H O H O H O 2 2 2 This diagram was automatically generated by SRI International Pathway Tools version 25.0, authors S. Paley and P.D. Karp.