Authors: Zheng Zhao, Delft University of Technology Marcel A. van den Broek, Delft University of Technology S. Aljoscha Wahl, Delft University of Technology Wilbert H. Heijne, DSM Biotechnology Center Roel A. Bovenberg, DSM Biotechnology Center Joseph J. Heijnen, Delft University of Technology An online version of this diagram is available at BioCyc.org. Biosynthetic pathways are positioned in the left of the cytoplasm, degradative pathways on the right, and reactions not assigned to any pathway are in the far right of the cytoplasm. Transporters and membrane proteins are shown on the membrane. Marco A. van den Berg, DSM Biotechnology Center Peter J.T. Verheijen, Delft University of Technology Periplasmic (where appropriate) and extracellular reactions and proteins may also be shown. Pathways are colored according to their cellular function. PchrCyc: Penicillium rubens Wisconsin 54-1255 Cellular Overview Connections between pathways are omitted for legibility. Liang Wu, DSM Biotechnology Center Walter M. van Gulik, Delft University of Technology L-quinate phosphate a sugar a sugar a sugar a sugar multidrug multidrug a dicarboxylate phosphate a proteinogenic 2+ 2+ + met met nicotinate Mg Mg a cation a cation K + L-fucose L-fucose L-quinate L-quinate L-quinate ammonium UDP ammonium ammonium H O pro met amino acid a sugar a sugar a sugar a sugar a sugar a sugar a sugar a sugar a sugar a sugar a sugar K oxaloacetate L-carnitine L-carnitine L-carnitine 2 phosphate quinic acid brain-specific hypothetical hypothetical hypothetical hypothetical ATP-binding mitochondrial permease high-affinity Na-dependent high-affinity sugar sugar sugar sugar hypothetical hypothetical mitochondrial cation-Cl- potassium L-fucose L-fucose cassette hypothetical MFS quinate quinic acid quinic acid dicarboxylate ammonium ammonium ammonium aquaporin high affinity high affinity hypothetical sugar transport sugar sugar sugar sugar transport sugar transport sugar sugar sugar transport sugar sugar K+/H+ oxaloacetate QA-Y - inorganic inorganic UDP-N-acetylglucosamine- carnitine carnitine carnitine proline methionine uptake nicotinic acid transporter transporter transporter transporter magnesium/ magnesium/ cation cotransporter- transport permease permease multidrug multidrug efflux transport permease permease transport transport transport transport water channel methionine methionine neutral amino protein Stl1 - transporter transporter transporter protein Stl1 - protein Stl1 - transporter transporter protein Stl1 - transporter transporter exchanger Kha1 transporter Oac1 Neurospora phosphate/H+ phosphate -dolichyl-phosphate N- transporter Agp2 transporter Agp2 transporter Agp2 transporter Put4 protein Mup3 - permease Tna1 - encoded by encoded by encoded by encoded by cobalt transport cobalt transport transporter Mmt1 interacting protein Trk2 - fucP - fucP - transport transporter - protein qutD QA-Y - QA-Y - protein protein Mep2 - protein Mep2 - protein Mep3 - protein Aqy2 - permease Mup1 - permease Mup1 - acid permease Saccharomyces Sut2 -Pichia Sut2 -Pichia Sut2 -Pichia Saccharomyces Saccharomyces Sut2 -Pichia Sut2 -Pichia Saccharomyces Sut2 - Sut2 -Pichia -Saccharomyces - Saccharomyces crassa symporter Pho84 cotransporter acetylglucosaminephosphotransferase - Saccharomyces - Saccharomyces - Saccharomyces - Saccharomyces Saccharomyces Saccharomyces DRA0271 - DRA0271 - DRA0271 - DRA0271 - protein sll0671 - protein sll0671 - - Saccharomyces protein CIP1 - Saccharomyces Escherichia Escherichia protein atrB Schizosaccharomyces - Aspergillus Neurospora Neurospora like protein Saccharomyces Saccharomyces Saccharomyces Saccharomyces Saccharomyces Saccharomyces - Neurospora cerevisiae stipitis stipitis stipitis cerevisiae cerevisiae stipitis stipitis cerevisiae Pichia stipitis stipitis cerevisiae cerevisiae [putative - Saccharomyces like protein Alg7 - Saccharomyces cerevisiae cerevisiae cerevisiae cerevisiae cerevisiae cerevisiae cerevisiae Deinococcus Deinococcus Deinococcus Deinococcus Synechocystis sp Synechocystis sp cerevisiae Homo sapiens cerevisiae coli coli - Aspergillus pombe nidulans crassa crassa An02g01730 - cerevisiae cerevisiae cerevisiae cerevisiae cerevisiae cerevisiae crassa hypothetical sequencing cerevisiae An04g02720 - radiodurans radiodurans radiodurans radiodurans nidulans Aspergillus niger neutral amino error] Aspergillus niger a proteinogenic a proteinogenic acid permease amino acid amino acid UDP - Neurospora a sugar a sugar a sugar a sugar a sugar a sugar a sugar a sugar a sugar a sugar a sugar K + multidrug oxaloacetate L-carnitine L-carnitine L-carnitine nicotinate Mg 2+ Mg 2+ a cation a cation K + L-fucose L-fucose L-quinate L-quinate L-quinate ammonium phosphate ammonium ammonium H O pro met a proteinogenic crassa 2 met met a sugar a sugar a sugar a sugar multidrug a dicarboxylate phosphate amino acid L-quinate phosphate hypothetical 1D-myo-inositol neutral amino a proteinogenic a proteinogenic 1,2,3,4,5,6- acid permease amino acid amino acid hexakisphosphate Other Biosynthesis Amino Acid Degradation - Neurospora phytase phyA Tetrapyrrole Biosynthesis crassa from patent 3-amino-3- D-ribose 5- a [BCAA a [BCAA RNase III mRNA 6-phospho- D-fructose- a branched- (25R)-3α,7α,12α- a (2S)-2- tetrahydrofolate biosynthesis II Cofactor, Carrier, and Vitamin Biosynthesis respiration (anaerobic) Respiration leucine degradation I a DNA containing an succinyl-CoA a 3-oxo acid an acyl-[acyl- sn-glycerol- a nucleoside 3'-ketolactose Peptide N-acetyl- a proteinogenic an acyl-CoA WO2003038111- flavin biosynthesis III (fungi) ubiquinone-8 ubiquinone-10 ubiquinone-9 ubiquinone-7 biosynthesis (eukaryotic) superpathway of NAD biosynthesis in eukaryotes NAD salvage biotin biosynthesis I (R,R)-butanediol 2-ketoglutarate dehydrogenase complex valine degradation I isoleucine degradation I leucine degradation III deoxy-D-fructose phosphate dehydrogenase dehydrogenase processing RNA D-gluconate 6-phosphate chain 2-keto acid trihydroxy-5β- methylacyl-CoA heme biosynthesis II Aromatic Compound Biosynthesis tyrosine degradation I arginine degradation glycine cleavage complex isoleucine degradation II Aldehyde Degradation apurinic/apyrimidinic site carrier protein] 3-phosphate triphosphate adenosine L-citrulline amino acid dicarboxylic A2-Penicillium biosynthesis (eukaryotic) biosynthesis (eukaryotic) biosynthesis (eukaryotic) pathway II biosynthesis 6-phosphate 2-keto-3- E2 protein] N 6 4-methyl-2- E2 protein] N 6 substrate decarboxylating fructose-2,6- dehydrogenase methionine-N- cholestanoyl-CoA hypothetical acyl-CoA all-trans- a [2-oxoglutarate VI (arginase 2 pathway) branched-chain hypothetical L-amino-acid amino acid D-myo-inositolchrysogenum: phyA GDP/GTP 2-phospho-D-glycerate a [glycine-cleavage methyl-valerate -lipoyl-L-lysine oxopentanoate -lipoyl-L-lysine phosphogluconate bisphosphate acetyltransferase protein a oxydaseproteinogenic tylP - a proteinogenic GTP formylTHF biosynthesis II heptaprenyl chorismate biosynthesis I dehydrogenase leu 6 apurinic endonuclease beta- alpha-ketoacid protein oxidase lox - permease Dip5 - (1,2,4,5,6)- chorismate 4-hydroxybenzoate 4-hydroxybenzoate formylTHF biosynthesis I 4-hydroxybenzoate trp NADP + ala gly (R)-acetoin val ile leu complex H protein] N glycine ile methylglyoxal degradation I methylglyoxal Succinyl CoA: dehydrogenase like 2-phosphatase Nat2 - CAD16864.1 Streptomyces exchange GTP pimeloyl-CoA chorismate biosynthesis 4-hydroxybenzoate 6 tyr sn-glycerol- DNA-directed acetylornithine amino acid amino acid GDP GDP para-hydroxybenzoate- para-hydroxybenzoate- diphosphate enolase BAC82549- E2 protein] N oxoglutarate branched-chain- arg -[(R)-lipoyl]-L-lysine decarboxylase Apn1 - Saccharomyces transketolase 3-oxoacid CoA ribonuclease protein An11g06120 galactosidase dehydrogenase CAD16864.1 Neurospora Saccharomyces pentakisphosphate protein Rom1 - acid 5-aminolevulinic acid from 3-dehydroquinate biosynthesis I (animals) 2,3-butanediol branched-chain- branched-chain- degradation V 3-phosphate RNA polymerase Fbp26 - Saccharomyces inosine-uridine - Ralstonia deacetylase fradiae: GTP GTP GTP -polyprenyltransferase -polyprenyltransferase indoleamine 2,3- D-erythrose- Penicillium -lipoyl-L-lysine dehydrogenase amino-acid arginase argA subunit H cerevisiae [putative like protein branched-chain branched-chain transferase III like protein -Aspergillus niger: lacA - kinase BCKDK - Ralstonia crassa: cerevisiae Saccharomyces 3,4-dihydroxy- tetrahydrofolate 7,8-dihydropteroate phosphatase synthase hemA - dehydrogenase branched-chain- branched-chain- aromatic aminotransferase amino-acid amino-acid methylglyoxal acyltransferase III 82 KD Saccharomyces cerevisiae: nucleosid solanacearum: argE - PC22G07740 cyclohydrolase ppt1p - ppt1p - dioxygenase IDO - Mus 8-amino-7- 4-phosphate chrysogenum: precursor of (lipoamide) Kgd1 aminotransferase -Aspergillus precursor of like protein methylglyoxal sequencing error]: An02g06430 alpha-keto acid alpha-keto acid SCOT - Homo An03g00790 PC12G08920 Aspergillus - Rattus solanacearum: PC20G15180 cerevisiae 2-butanone 4-hydroxybenzoate aphA - Aspergillus nidulans: phe-inhibited 3-dehydroquinate 4-hydroxyphenylpyruvate ADH - amino-acid amino-acid I Aro8 - Saccharomyces aminotransferase aminotransferase glyoxalase I Glo1 like protein subunit Rpc82 - cerevisiae: PC20G00190 hydrolase PC21G07860 Myxococcus acyl-CoA I Fol2 - Schizosaccharomyces Schizosaccharomyces musculus: PC22G11860 oxononanoate PC14G01740 dihydrolipoamide - Saccharomyces Bat2 - niger: dihydrolipoamide An08g04390 - PC22G09800 - Aspergillus dehydrogenase dehydrogenase sapiens: - Aspergillus niger: norvegicus: PC21G07860 L-amino-acid amino acid 4-phosphate dihydrofolate Aspergillus PC22G13500 DAHP 3-dehydroquinate Pseudomonas aminotransferase aminotransferase cerevisiae: PC12G11860 Bat2 - Bat2 - -Saccharomyces An18g01960 - Saccharomyces decarboxylating PC20G01550 IUNH - Crithidia xanthus: oxydase tylP - Saccharomyces pombe: PC22G22880 pombe: PC22G22880 3-heptaprenyl-4- synthase/KAPA dehydrogenase cerevisiae: Saccharomyces PC13G09710 dehydrogenase Aspergillus niger: niger: E1 alpha subunit E1 alpha subunit PC22G03940 niger: PC14G01510 PC21G16190 subunit of the hypothetical hypothetical oxidase lox - a proteinogenic transporter a proteinogenic synthase Rib3 - para-hydroxybenzoate- synthetase: PC13G07660 N-formylkynurenine ficuum: 5-amino-levulinate synthase aroG dehydratase: putida: phosphoenolpyruvate Bat2 - Bat2 - Saccharomyces Saccharomyces cerevisiae: PC12G09820 apurinic/apyrimidinic Aspergillus niger: cerevisiae: phosphogluconate fasciculata: PC14G01770 Streptomyces GDP/GTP cerevisiae: glycine cytoplasmic serine hydroxybenzoate synthase BioF Lpd1 - PC22G04770 cerevisiae: 4-hydroxyphenylpyruvate L-ornithine Lpd1 - PC12G15080 PC18G00660 BCHEL1 - BCHEL1 - PC20G04580 6-phosphofructo- secreted beta- branched-chain major N alpha- protein protein Neurospora amino acid ATA1 -Homo amino acid Saccharomyces tetrahydrofolate biosynthesis -polyprenyltransferase para-hydroxybenzoate- para-hydroxybenzoate- PC22G09580 - Aspergillus PC16G12160 3-(4-hydroxyphenyl) PC23G00940 Saccharomyces Saccharomyces cerevisiae: cerevisiae: L-lactaldehyde (AP) endonuclease succinyl-CoA:3- PC21G05490 PC12G05490 dehydrogenase like PC13G11080 fradiae: exchange PC21G16300 decarboxylase hydroxymethyltransferase - Kurthia sp: porphobilinogen Saccharomyces PC22G16780 Saccharomyces lactoylglutathione lyase transketolase Tkl1 Homo sapiens: Homo sapiens: ribonuclease 2-kinase/ galactosidase alpha-ketoacid acetyltransferase CAD16864.1 CAD16864.1 acetylornithine crassa: sapiens GDP GDP cerevisiae: ppt1p - -polyprenyltransferase -polyprenyltransferase 7,8-dihydrofolate arylformamidase: nidulans: 3-dehydroshikimate lactate [+ 14 isozymes] cerevisiae: cerevisiae: PC22G16780 glycine PC22G16780 Apn2 - Saccharomyces ketoacid-CoA protein An11g06120 PC16G05030 protein Rom1 - subunit H Shm2 - Saccharomyces [+ 4 isozymes] PC13G12580 synthase like protein (R,R)-2,3- pyruvate kinase cerevisiae: 4-hydroxyphenylpyruvate ornithine cerevisiae: glyoxalase-I - Lycopersicon -Saccharomyces PC12G08790 PC12G08790 III like protein [+ 27 isozymes] fructose 2,6- lacA - dehydrogenase Ard1 - - Ralstonia - Ralstonia deacetylase PC16G06420 GTP GTP GTP Schizosaccharomyces ppt1p - ppt1p - PC22G06360 NAD + PC22G22180 a [2-oxoglutarate a [2-oxoglutarate 4-methyl-2-[+ 4 isozymes] PC22G16780 PC22G16780 dehydrogenase aldehyde cerevisiae: PC20G07790 transferase -Aspergillus niger: a (2E)-2- Saccharomyces PC22G02310 dihydrofolate cerevisiae: PC13G05010 An08g00010 - multifunctional butanediol pkiA -Aspergillus PC20G04720 dioxygenase HPPD transaminase 4-methyl-2-[+ 4 isozymes] PC20G04720 2-keto-3-[+ 4 isozymes] esculentum: PC12G12020 cerevisiae: bisphosphatase Saccharomyces solanacearum argE - cyclohydrolase pombe: PC22G22880 Schizosaccharomyces Schizosaccharomyces like protein cytoplasmic serine dehydrogenase dehydrogenase oxopentanoate [+ 4 isozymes] [+ 4 isozymes] component P - dehydrogenase Arp2/3 Arp2/3 SCOT - Homo An03g00790 PC19G00410 Aspergillus kinase BCKDK solanacearum D-ribose a 2-oxo acid enoyl-CoA cerevisiae GTP reductase 3-heptaprenyl-4,5- Aspergillus niger: 3-deoxy-[+ 2 isozymes] protein aroM niger: PC18G06000 - Mycosphaerella otaA - oxopentanoate methyl-valerate S-lactoyl-glutathione PC13G12450 a 2-lysophosphatidate like protein cerevisiae: adenine [putative Myxococcus hypothetical I Fol2 - GTP pombe: PC16G00380 pombe: PC16G00380 An08g04390 cytoplasmic serine hydroxymethyltransferase kynurenine putative NAD+ 7-keto-8- shikimate E2 protein] N 6 E2 protein] N 6 -S- Pisum sativum: aldA - complex 34 complex 34 sapiens: - Aspergillus RNA D-ribulose- niger: - Rattus [putative para-hydroxybenzoate- 3-decaprenyl-4- nonaprenyl-4- DHFR - dihydroxybenzoate PC16G01700 D-arabino- - Aspergillus oxaloacetate 2-keto-3- graminicola: PC22G07130 Aspergillus a [glycine-cleavage An15g00200 - PC16G06600 sequencing xanthus: neutral amino cyclohydrolase - Aspergillus hydroxymethyltransferase Shm2 - Saccharomyces diphosphatase: aminopelargonate dehydrogenase: 2-oxoisovalerate pyruvate a [glycine-cleavage 6 Aspergillus niger: a 3'-terminal unsaturated sugar a 5'-phosphopolynucleotide kD subunit kD subunit niger: PC06G00600 norvegicus: sequencing a proteinogenic a proteinogenic Saccharomyces 4-coumarate -dihydrolipoyl- succinyldihydrolipoyl- complex H protein]PC14G00390 N - hydroxyacylglutathione PC14G00590 5-phosphate α stimulatory -polyprenyltransferase hydroxybenzoate hydroxybenzoate Pneumocystis 3,4-dihydroxy-5- heptulosonate- nidulans: methyl-valerate nidulans: 6 Aspergillus niger: an N -acetyl- error]: PC13G03320 acid permease cerevisiae: II like protein GTP dihydrofolate niger: Shm2 - Saccharomyces cerevisiae: PC13G05010 PC22G00320 biotin synthesis PC16G12160 pyruvate L-lysine L-lysine homogentisate decarboxylase complex H protein] N hydrolase RSP29 - Rattus PC06G00180 1-deoxy-1-imino- D-sedoheptulose BCKDH - BCKDH - PC12G01930 a phosphorylatedPC12G11940 error]: amino acid amino acid GDP/GTP ppt1p - carinii: hexaprenylbenzoate porphobilinogen 7-phosphate PC22G17290 mitochondrial malate PC18G03600 aminomethyldihydrolipoyl- PC12G04520 peptide PC13G07100 - Neurospora GDP GDP PC20G04620 An10g00350 - cyclohydrolase synthetase: PC12G15080 cerevisiae: PC12G16020 cytoplasmic serine nicotinamide enzyme 4-coumarate- dcpY - -dihydrolipoyl-L-lysine norvegicus: PC21G08590 [+ 10 isozymes] D-erythrose 7-phosphate Gallus gallus: Gallus gallus: 3-keto-β-D- branched-chain (25S)-3α,7α,12PC13G07100α- exchange Schizosaccharomyces PC13G03650 methyltransferase - 3-dehydroquinate dehydrogenase isovaleryl-CoA L-lysine a 2,3,4-saturated β-D-fructose 2,6- β-D-glucose a (2R)-2- crassa GTP GTP 7,8- Aspergillus niger: I Fol2 - 7,8- PC13G07660 5-methyl- hydroxymethyltransferasedihydrofolate reductase mononucleotide like protein hydroxymethylbilane pentafunctional CoA ligase homogentisate 1,2- L-glutamate γ- Aspergillus 2-methylbutanal 4-phosphate PC12G11200 PC12G11200 succinate RNase III galactose 2-keto acid trihydroxy-5β- protein GDS pombe: PC16G00380 7,8-dihydrofolate Rattus norvegicus: synthase: MDH - Mus musculus: glyoxalase like protein (S)-lactate 3-oxoacyl-CoA a single- bisphosphate methylacyl-CoA dihydroneopterin PC20G05890 Saccharomyces dihydropteroate tetrahydrofolate Shm2 - SaccharomycesDHFR -Pneumocystis 3-hydroxy-L-kynurenine An15g01990 synthase Hem3 - enzyme aroM 4CL - isovaleryl- S-2-methyl- dioxygenase: PC12G09040 semialdehyde parasiticus: processing dehydrogenase cholestanoyl-CoA acetate L-citrulline - Bos taurus 2,5-diamino-6- 3-octaprenyl-4- 3-decaprenyl-4,5- 3-nonaprenyl-4,5- thymidylate synthase PC22G12370 5-nucleotidase PC16G12160 PC21G22090 isobutyryl-CoA thermostable alcohol An11g07320 - Aspergillus stranded RNA dicarboxylic triphosphate cerevisiae: cerevisiae: PC12G16020carinii: PC13G03650 - Aspergillus Saccharomyces - Aspergillus Arabidopsis dihydrolipoamide coenzyme A butyryl-CoA homogentisate 1,2- PC18G01490 an [apo BCAA dehydrogenase a [apo BCAA dehydrogenase product mRNA (5-phospho-D- hydroxybenzoate dihydroxybenzoate dihydroxybenzoate CATSA - Candida 3-heptaprenyl- 5NTD_DISOM [+ 3 isozymes] dehydrogenase niger: PC16G09730 flavocytochrome amino acid PC21G16300 thymidylate nidulans: succinyltransferase dioxygenase HGO - Homo 6 6 ribosylamino) kynureninase - Rattus - Discopyge niger: cerevisiae: PC22G16690 3-dehydroquinate thaliana: acetyl-CoA formate branched-chain α-keto acid dehydrogenase complex dehydrogenase 2-methylacyl-CoA 2-methyl branched- L-cysteine [+ 3 isozymes] E2 protein] N -S-[2- E2 protein] N -S-[3- a proteinogenic a proteinogenic citrate transport 3,4-dihydroxy-5- 3,4-dihydroxy-5- synthase albicans: PC13G06460 4-hydroxy-5- PC16G12160 (S)-malate kgd2 - Aspergillus sapiens: PC21G22500 adhT - Bacillus (R)-lactate b2 L-lactate permease Dip5 - pyrimidin- GTP norvegicus: PC22G20570 nicotinamide ommata: PC20G13420 hydroxymethylbilane PC22G24780 like protein dehydrogenase: chain acyl-CoA degradation I methylbutanoyl]dihydrolipoyl- methylbutanoyl]dihydrolipoyl- amino acid amino acid protein Ctp1 - hexaprenylbenzoate hexaprenylbenzoate CATSA - methylenetetrahydrofolate glycine decarboxylase methoxybenzoate 3-dehydroquinate fumigatus: branched-chain 3-methylbutanal glycine stearothermophilus: dehydrogenase Saccharomyces citrate citrate 4(3H)-one cyclohydrolase PC22G00320 7,8- synthase Hem3 - [+ 2 isozymes] glyoxysomal citrate a [BCAA dehydrogenase An07g04280 - PC16G13490 dehydrogenase: (S)-1-pyrroline- L-lysine L-lysine Saccharomyces dihydroneopterin methyltransferase - methyltransferase - Candida reductase (NADPH) 5,10-methylenetetrahydrofolate subunit H like protein tetrahydrofolate dehydratase: shikimate fumarate hydratase PC20G08570 alpha-keto acid 4-maleyl-acetoacetate decarboxylase PC22G24580 protein D-lactate CYB2 - Pichia cerevisiae I Fol2 - 3-octaprenyl-4,5- ubiquinone-6 biosynthesis (eukaryotic) 3-hydroxyanthranilate synthase - Cucurbita 6 Aspergillus niger: PC16G13490 5-carboxylate cerevisiae phosphate Rattus norvegicus: Rattus norvegicus: Met12 -Saccharomyces An08g04390 - Aspergillus nicotinamide diaminopelargonate Saccharomyces PC16G12160 4-coumaroyl-CoA fumR - Rhizopus E2 protein] N cys thermostable alcohol subunit T Gcv1 - [+ 11 isozymes] dehydrogenase YEL071w anomala: Saccharomyces dihydroxybenzoate albicans: shikimate sp: PC12G00660 dehydrogenase PC21G01100 methylacrylyl-CoA pyrroline-5- PC22G12370 PC22G12370 niger: PC12G15080 riboside dethiobiotin cerevisiae: PC21G06870 oryzae: PC22G23810 -lipoyl-L-lysine maleylacetoacetate dehydrogenase Saccharomyces - Saccharomyces PC22G00300 S-(2-hydroxyacyl) 6-phospho- a phosphorylated ∆ 1 -piperideine- a trans-delta18- campest- a [protein]- hypothetical cerevisiae: PC13G06460 cerevisiae: PC21G15910 methylenetetrahydrofolate 2-heptaprenyl-6- 3-hydroxyanthranilic CO E1 alpha subunit tigloyl-CoA palmitate indole-3-glycerol- 2-oxoglutarate acetylcholine a nucleoside 3',5'- ATP AMP a reduced c- cellobiose formaldehyde 3,4-dihydroxy-5- 3-decaprenyl- 3-nonaprenyl- all-trans-hexaprenyl synthetase: 3-dehydroshikimate kinase: 2 3-methylcrotonyl- isomerase: PC12G09020 carboxylate cysteine adhT - Bacillus cerevisiae: 2-methylbutanol cerevisiae: PC21G14970 SAM ser pro D-gluconate pyruvate 37-hydroxy- 4-en-3β-ol citrate transport 2,5-diamino-6- PC20G04620 methylenetetrahydrofolate reductase (NADPH) acid dioxygenase NAD + hydroxymethylbilane citrate hypothetical protein BCHEL1 - mitochondrial [+ 4 isozymes] a diphospho-5'- GTP phosphate glutathione cyclic phosphate type cytochrome 6-carboxylate guanosine L-tyrosine neutral amino hexaprenylbenzoate 4-hydroxy-5- 4-hydroxy-5- methoxyphenol diphosphate PC20G13420 PC16G12160 precursor of CoA reductase dioxygenase stearothermophilus: PC16G07470 cGMP decarboxylating dehydrogenase L-aminoadipate- cellobiose 20,38-dimethyl- C-3 sterol receptora proteinogenic a proteinogenic protein Ctp1 - (5-phospho- 7,8- reductase Met13 Met12 -Saccharomyces Bna1 - Saccharomyces SPAC30C2.08 - Homo sapiens: enoyl-CoA mitochondrial purine-3'-[mRNA] cytochrome- pyruvate acid permease citrate citrate methyltransferase - methoxybenzoate methoxybenzoate multifunctional mitochondrial aconitate dihydrolipoamide 4-fumaryl-acetoacetate P5CR - CDO1 - Rattus PC22G24580 pyruvate pyruvate phosphodiesterase phosphogluconate semialdehyde dehydrogenase C58:1-[acp] dehydrogenase tyrosine amino acid amino acid Saccharomyces 7,8-dihydro- D-ribitylamino) dihydroneopterin - Saccharomyces cerevisiae: PC21G15910 cerevisiae: PC20G02370 nicotinamide uroporphyrinogen- shikimate-3- Schizosaccharomyces PC12G08790 3-methylcrotonyl- hydratase enoyl-CoA proline degradation long-chain-fatty-acid- hydroxyacylglutathione cholinesterase 1 adenylate c peroxidase dehydrogenase cyclopropane- formaldehyde - Neurospora Rattus norvegicus: NAD+ synthetase, putative NAD+ dethiobiotin protein aroM shikimate 4-hydroxybenzoyl-CoA hydratase Aco1 - dehydrogenase Zalerion norvegicus: prolyl-4- like protein dehydrogenase like dehydrogenase CBDH - Humicola Erg26 - kinase CCK- cerevisiae D-neopterin pyrimidin- triphosphate cerevisiae: PC15G00480 3-hexaprenyl-4- 3-hydroxyanthranilic mononucleotide III synthase Hem4 phosphate pombe: PC13G03060 CoA carboxylase ECHS1 - Rattus hydratase [+ 11 isozymes] -CoA ligase Faa2 ACC synthase tryptophan hydrolase RSP29 - ChE1 -Branchiostoma kinase Adk2 - precursor Ccp1 - phosphatase fatty-acyl- dismutase crassa PC22G12370 5,10- methylenetetrahydrofolate superpathway of pyridoxal 5'-phosphate biosynthesis and salvage glutamine dependent: diphosphatase: - Aspergillus dehydrogenase: Saccharomyces Lpd1 - Arp2/3 arboricola: PC21G04760 hypothetical mRNA- hydroxylase- An01g04450 - protein An11g06120 large subunit inosine-uridine insolens: Saccharomyces 2 like protein 4(3H)-one 2-heptaprenyl- hydroxybenzoate acid dioxygenase biotin - Saccharomyces 3-phosphoshikimate-1- (MCC) biotin- norvegicus: ECHS1 fumarylacetoacetase -Homo - Saccharomyces acs -Penicillium synthase Trp5 - Rattus norvegicus: floridae: PC21G13140 Saccharomyces Saccharomyces isoenzyme 1 phospholipid like protein chorismate methylenetetrahydrofolate reductase Met13 PC21G16060 PC22G00320 nicotinamide nidulans: PC16G12160 cerevisiae: PC22G02000 fumarate Saccharomyces complex 34 PC22G23710 3-methylbutanol pro capping enzyme alpha like Aspergillus niger: -Aspergillus niger: Lys2-Penicillium nucleosid PC20G04990 cerevisiae: An13g01560 H+-biotin 3-octaprenyl-4-hydroxy- 2-decaprenyl-6- 2-nonaprenyl-6- D-erythrose- 6-methoxy-1,4- Bna1 - Saccharomyces synthase Bio2 - cerevisiae: PC22G01660 carboxyvinyltransferase: containing alpha PC22G21270 - Rattus sapiens: PC12G09030 cysteine glutamate degradation IV cerevisiae: PC12G05520 citrinum: Saccharomyces PC21G08590 cerevisiae: cerevisiae: PDP1 - Rattus like protein An07g07160 dicarboxylic - Saccharomyces mononucleotide PC22G17290 cerevisiae: kD subunit [+ 2 isozymes] proline subunit SPAC644.04 - protein acetylcholinesterase PC16G10380 PC12G08920 chrysogenum: hydrolase PC18G05820 - Aspergillus symporter Vht1 - 5-methoxybenzoate methoxyphenol methoxyphenol trifunctional C1- 4-phosphate benzoquinone cerevisiae: PC20G09330 Saccharomyces PC16G12160 mitochondrial subunit MCCA - norvegicus: fumarylacetoacetase -Homo dioxygenase phosphate acquisition II PC20G03240 cerevisiae: PC13G03220 PC22G00860 norvegicus: cellobiose An13g00740 - Aspergillus amino acid 6-hydroxymethyl- aminodeoxychorismate cerevisiae: PC15G00480 nicotinate adenine dinucleotide nicotinamide mononucleotide adenylyl uroporphyrinogen-III pentafunctional 4-hydroxyphenylpyruvate PC20G04720 BCKDH - (S)-3-hydroxy-isobutyryl-CoA dehydrogenase acyl-CoA synthase like Schizosaccharomyces glyoxalase An02g07870 AChE - Rattus Lys2 IUNH - Crithidia aniger: proteinogenic a proteinogenic Saccharomyces dihydroneopterin tetrahydrofolate cerevisiae: 5-enolpyruvyl- aconitase hydroxylase Homo sapiens: PC22G21270 sapiens: PC12G14070 CDO1 - Rattus methionine degradation 1-aminocyclopropane- PC22G13470 cyclic nucleotide decarboxylating cytochrome- PC13G02990 dehydrogenase - Aspergillus C-3 sterol niger: permease Dip5 - biotin biotin 7,8-dihydropterin synthase: trpC D-ribulose- 5-amino-6-(5- 3-hexaprenyl-4,5- transferase enzyme aroM 4-hydroxybenzoate biosynthesis Gallus gallus: pro glt slgA -Drosophila acid phosphatase protein An18g03800 pombe [putative like protein -Aspergillus norvegicus: adenylate fasciculata: PC16G12520 amino acid amino acid cerevisiae phosphate synthase Ade3 - aminocarboxymuconate semialdehydenicotinate-nucleotide PC20G13470 shikimate-3- Aco1 - Saccharomyces PC21G01060 3-hydroxyisobutyryl- 2-methyl-3- norvegicus: I (to homocysteine) 1-carboxylate tryptophan phosphodiesterase phosphogluconate c peroxidase aminoadipate CDH - Trametes niger: dehydrogenase PC18G04830 a [protein]- Saccharomyces 5-phosphate phospho-D- dihydroxybenzoate NMNAT - uroporphyrinogen - Aspergillus an [apo BCAA PC12G11200an [apo BCAA dehydrogenase melanogaster: aphA -Aspergillus - Aspergillus niger: sequencing error]: An11g07320 niger: PC13G15690 kinase Adk1 - pyruvate PC13G11080 [putative 6-hydroxymethyl- 4-amino-4- Saccharomyces 5-methyl-tetrahydrofolate 2-heptaprenyl- pyrophosphorylase phosphate cerevisiae: PC13G03110 [+ 2 isozymes] CoA hydrolase: hydroxybutyryl- PC18G02180 synthase acs - synthase Trp5 - PDE1 - Candida dehydrogenase like precursor Ccp1 - reductase versicolor: a trans- PC21G04500 Erg26 - L-tyrosine cerevisiae ribosylamino)uracil 2-octaprenyl-6- 2-decaprenyl- 2-nonaprenyl- Homo sapiens: decarboxylase like nidulans: tyr succinate dehydrogenase E2 protein] N 6 -S-[2- acetoacetate fumarate glutamate decarboxylase PC21G19930 ficuum: PC22G09580 PC13G01890 PC16G07630 - Aspergillus PC18G00410 Saccharomyces dehydrogenase sequencing error] 7,8-dihydropterin deoxychorismate cerevisiae: erythronate- 3-methyl-6- 3,4-dihydroxy-5- (carboxylating) biotin chorismate 3-methylglutaconyl- PC22G21270 CoA Penicillium citrinum: Saccharomyces albicans: protein An11g06120 Saccharomyces enzyme lys2 - PC20G15200 methoxy-C60- Saccharomyces phosphate methoxyphenol 6-methoxy-1,4- 6-methoxy-1,4- PC12G08660 protein An01g04250 cis-aconitate E2 protein] N 6 - methylpropanoyl]dihydrolipoyl- met niger: cerevisiae: phosphatase pyrophosphokinase: 4-phosphate hexaprenylbenzoate QPRTase - Homo PC16G12160 synthase: aromatic aminotransferase 3-sulfinoalanine GAD1 - Arabidopsis [+ 2 isozymes] [+ 4 isozymes] PC16G08030 mRNA PC16G13410 -Aspergillus niger: Acremonium cellobiono- meroacyl-[acp] cerevisiae: H+-biotin benzoquinol benzoquinol PC20G03600 methoxy-1,4- - Aspergillus niger: dihydrolipoyl-L-lysine L-lysine CoA S-adenosylmethionine (S)-1-pyrroline- a phosphate monoester phosphate cerevisiae: PC16G09730 acetate choline PC12G05310 cerevisiae: isoenzyme 1 D-ribose formate methanol hypothetical PC20G04620 7,8-dihydro- 2-octaprenyl-6- methyltransferase - sapiens: PC20G08420 + PC14G02010 I Aro8 - Saccharomyces (S)-3-hydroxy-isobutyrate thaliana: PC22G00970 a nucleoside- PC19G00410 1,5-lactone symporter Vht1 - 1-deoxy-L- benzoquinol NAD 3-dehydroquinate 5-carboxylate + guanylyltransferase PC21G03590 trans-4-hydroxy- PC18G03560 chrysogenum: PC12G00300 neutral amino biotin biotin 6-hydroxymethyl- formate-tetrahydrofolate quinolinate nicotinate mononucleotide nicotinamide PC16G10100 shikimate cerevisiae: PC12G11860 mitochondrial aconitate Methylglutaconyl- valine degradation II synthase eth-1 - AMP palmitoyl-CoA diphosphate H succinate PDP1 - Rattus guanine Saccharomyces glycero-tetrulose 5-amino-6-(D- D-neopterin methoxyphenol 5,10- Rattus norvegicus: biosynthesis I cytosolic [+ 2 isozymes] - Saccharomyces L-proline 5'-phosphate D-ribulose- an oxidized c- PC20G02260 campest-4- a proteinogenic acid permease a proteinogenic dihydropterin ligase: PC20G03600 chorismate 4-hydroxyphenylpyruvate hydratase Aco1 - CoA hydratase, 3-hydroxyisobutyrate 2-methylacetoacetyl- Neurospora crassa: delta-1-pyrroline- S-methyl-5'- norvegicus: cerevisiae p-aminobenzoate 4-phosphate ribitylamino)uracil hydroxylase: methenyltetrahydrofolate PC22G12370 coproporphyrinogen III shikimate aspartate 1-aminocyclopropane- cerevisiae: a 2-hydroxy 5-phosphate type cytochrome en-3-one amino acid - Neurospora amino acid chorismate 2-oxo-3-hydroxy-4- D-erythrose- Saccharomyces mitochondrial: dehydrogenase CoA PC16G04380 4-aminobutyrate 5-carboxylate glutathione peroxidase D-glyceraldehyde- glutathione ADP H + PC13G10200 2-aminoadipate diphosphate PC22G22890 2-decaprenyl- 2-nonaprenyl-3- 3-hexaprenyl-4-hydroxy- kinase: thioadenosine 1-carboxylate PC22G09050 carboxylate pyruvate methenyltetrahydrofolate phosphobutanoate 4-phosphate cerevisiae: PC22G02000 PC21G09480 mmsB - val transaminase SAM dehydrogenase Hyr1 - Saccharomyces 3-phosphate trp crassa 2-octaprenyl-6-methoxy- 3-methyl-6- methyl-6-methoxy- ubiquinone-7 A(H2) 5-methoxybenzoate coproporphyrinogen PC16G12160 phe-inhibited dehydrogenase sulfate dihydropteroate aminodeoxychorismate 10-formyl-tetrahydrofolate 3-demethylubiquinol-7 Aat2 - 4-aminobutyrate 4-aminobutyrate p5cdh - Homo cerevisiae: PC18G01780 α 6-hydroxymethyl- 1,4-benzoquinol methoxy-1,4- 1,4-benzoquinol cyclohydrolase: phosphoserine oxidase III Hem13 DAHP mitochondrial (S)-3-hydroxy-3- Pseudomonas precursor of branched-chain-amino- E1 permease SutB- synthase: synthase: trpC biotin biosynthesis II γ-glutamyl cycle shikimate-3- Saccharomyces phosphatidylethanolamine transaminase gatA - transaminase gatA - sapiens: A(H2) A dicarboxylic sulfate sulfate 7,8-dihydropterin benzoquinol PC20G03600 transaminase - Saccharomyces synthase aroG aconitase hydroxylase methylglutaryl-CoA aeruginosa: acetyl-CoA C- acid aminotransferase a G(5')ppPur-mRNA Penicillium PC22G19630 6,7-dimethyl-8-(1- phosphate cerevisiae: methyltransferase cho2p Aspergillus nidulans: Aspergillus nidulans: PC12G08900 amino acid 4-amino-4- 6-hydroxymethyl- methenyltetrahydrofolate Ser1 - nicotinate cerevisiae: PC12G05380 - Aspergillus Aco1 - Saccharomyces 3-hydroxy-3- PC13G07890 acetyltransferase - Bat2 -Saccharomyces a proteinogenic a proteinogenic chrysogenum D-ribityl)lumazine 10-formyl- trifunctional C1- Fermentation PC22G00210 - Schizosaccharomyces PC21G17880 PC21G17880 permease Dip5 - deoxychorismate 7,8-dihydropterin cyclohydrolase: Saccharomyces 2-hexaprenyl-6- ala glutathione 3-phosphoshikimate-1- nidulans: cerevisiae: PC13G03110 mixed acid fermentation methylglutaryl 3-hydroxyisobutyrate Rattus norvegicus: cerevisiae: PC22G16780 [+ 2 isozymes] amino acid amino acid 6,7-dimethyl-8- tetrahydrofolate tetrahydrofolate synthase pimeloyl-CoA protoporphyrinogen IX [+ 4 isozymes] pombe: PC21G02080 Saccharomyces 7,8- pyrophosphokinase: 2-octaprenyl-3-methyl-6- 3-demethylubiquinol-9 PC20G03600 cerevisiae: A ubiquinol-7 methoxyphenol carboxyvinyltransferase: PC22G22180 CoA lyase dehydrogenase PC22G00420 [+ 4 isozymes] sulfate ribityllumazine 3-demethylubiquinol- Ade3 - Saccharomyces D-threo-isocitrate 2-oxoisovalerate succinate semialdehyde 2-hydroxymuconate- trans-1,2- a [protein]-L- a (3R,11Z)-3- a [protein]- cerevisiae dihydropteroate PC20G04620 methoxy-1,4-benzoquinol PC12G04370 gamma- PC16G12160 phosphoenolpyruvate HMG-CoA mmsB - cytosolic 3-sulfinyl-pyruvate phosphatidyl-N- glt a long-chain fatty acid acetoacetate succinyl-CoA a cis-delta17- histone-L-lysine biotin carboxyl- a ubiquitin C- an oxidized an acyl-CoA H O a palmitoylated an acetic ester permease SutB 10 cerevisiae: PC20G03600 protoporphyrinogen 3-deoxy-D-arabino-[+ 2 isozymes] DL-allothreonine a malonyl-[acp] biotin 6-semialdehyde Dihydrobenzene- 2 proline (ω = 180) hydroxyoctadec- L-tyrosine dihydrofolate synthase Rib4 - 6-hydroxymethyl- 3-demethylubiquinone- formate- formyltetrahydrofolate 5,10-methenyltetrahydrofolate 8-amino-7- 5-enolpyruvyl- methylethanolamine C36:1-[acp] carrier protein dGTP a purine ribonucleoside terminal thioester hemoprotein xanthosine protein sulfate -Penicillium sulfate 4-phospho- Glutamyltranspeptidase oxidase PPO - Mus heptulosonate- precursor of lyase - Rattus Pseudomonas acetyl-CoA C- pyruvate histone-lysine N- 1,2-diol NADPH estrogen 11-enoyl-[acp]3-oxoacyl- phosphate synthetase: Saccharomyces dihydropterin 3-demethylubiquinone- 9 3-O- tetrahydrofolate deformylase purU oxononanoate shikimate-3- N-methyltransferase succinate-semialdehyde dimeric hypothetical hypothetical chrysogenum p-aminobenzoate hydroxy-L-threonine - Pseudomonas musculus: PC22G13300 7-phosphate mitochondrial isocitrate pyruvate kinase norvegicus: aeruginosa: acetyltransferase decarboxylase dcpY - methyltransferase cytochrome P450 receptor- (acyl-carrier- PC13G07660 cerevisiae: diphosphate 10 3-O- methyltransferase: ligase: - Corynebacterium 2-hexaprenyl-6-methoxy- synthase/KAPA phosphate Opi3 - Saccharomyces dehydrogenase like protein acyl-CoA synthase like Succinyl CoA: 2-hydroxymuconate- dihydrodiol thioesterase acetyl- dual specificity neutral amino aeruginosa: PC22G03740 3-dehydroquinate dehydrogenase pkiA -Aspergillus PC21G09480 PC13G11980 Erg10 - Aspergillus parasiticus: metal-activated pyridoxal like protein ubiquitin specific oxidoreductase binding protein) palmitoyl- a proteinogenic a proteinogenic PC14G01130 methyltransferase: PC22G12370 PC20G03600 sp: PC20G01960 5-formyltetrahydrofolate 1,4-benzoquinol synthase BioF protoporphyrin IX chorismate cerevisiae: An14g01440 - Aspergillus protein An18g03800 3-oxoacid CoA hypothetical 3- biotin-apoprotein semialdehyde dehydrogenase II hTE -Homo esterase I protein acid permease 7,8-dihydrofolate 3-demethylubiquinol-8 [+ 3 isozymes] synthase: icdA - Aspergillus niger: PC18G06000 3-hydroxy-3- (S)-methylmalonate- Saccharomyces PC18G01490 4-hydroxybutyrate enzyme D-threonine An11g09940 ras related inosine-uridine protease Ubp3 - cprA - inosine-uridine cyclophilin reductase protein amino acid amino acid sulfate dihydropteroate PC22G12370 cyclo-ligase MTHFS - Homo - Kurthia sp: synthase: PC16G02100 niger: PC12G14920 - Aspergillus niger: transferase SCOT oxoacyl-(acyl- ligase Bpl1 - hydrolase SUS2DD - sapiens: like protein phosphatase - Neurospora riboflavin ubiquinol-9 ferrochelatase PC16G12160 niger: PC20G03610 oxaloacetate methylglutaryl semialdehyde cerevisiae: [+ 3 isozymes] pyruvate sulfite aldolase - Arthrobacter - Aspergillus protein Rab7 - nucleosid Saccharomyces Aspergillus niger: nucleosid cypD - Bos fabG - Bacillus thioesterase permease SutA- synthase: 3-demethylubiquinone- sapiens: PC20G01330 (2S)-2-amino-3-oxo-4- PC13G12580 glutathione PC14G02010 [+ 7 isozymes] PC13G01890 - Homo sapiens: carrier-protein) Saccharomyces like protein Sus scrofa: PC22G07280 An07g08940 3 - Aspergillus crassa sulfate sulfate dihydrofolate ubiquinol-10 D-glyceraldehyde- fch -Danio rerio: CoA lyase PC22G10140 S-adenosyl-L- sp: PC20G14030 niger [putative Homo sapiens: hydrolase cerevisiae: PC21G13280 hydrolase primigenius subtilis: - Rattus Penicillium PC22G19630 8 3-O- tetrahydrofolate pyruvate phosphonooxybutanoate synthase Gsh2 - 2-oxoglutarate PC22G03940 synthase cerevisiae An07g09320 - PC13G11190 - Aspergillus fumigatus: reductase 3-phosphate 2-hexaprenyl-3-methyl-6- PC22G15520 chorismate 3-dehydroquinate pyruvate HMG-CoA isobutanal homocysteine long-chain-fatty-acid- sequencing error]: PC21G07250 IUNH - Crithidia PC22G11580 thioesterase IUNH - Crithidia taurus: PC16G12960 norvegicus: chrysogenum methyltransferase: Saccharomyces mitochondrial malate threonine aldolase T32M21.120 [putative Aspergillus niger: NADPH niger: PC13G11790 hypothetical DHFR - NAD biosynthesis methoxy-1,4-benzoquinol 7-keto-8- lyase - Rattus succinate -CoA ligase Faa2 succinyl-CoA:3- PC20G07620 [+ 3 isozymes] fasciculata: dimeric II hTE - Homo fasciculata: PC22G10250 PC13G15530 7,8- PC22G12370 5-formyl-tetrahydrofolate cerevisiae: dehydrogenase acetyl-CoA propanoyl-CoA thermostable alcohol adenosylhomocysteinase - Gly1 - Saccharomyces -Arabidopsis sequencing error]: PC18G04340 [+ 8 isozymes] cytochrome P450 an (11Z)-3-[+ 5 isozymes] PC18G06090 neutral amino Pneumocystis I (from aspartate) folate transformations aminopelargonate protoheme IX norvegicus: phenylalanine degradation III - Saccharomyces ketoacid-CoA PC13G11080 dihydrodiol sapiens: PC13G11080 [+a proteinogenic8 isozymes] a proteinogenic sulfate dihydropteroate PC21G17790 MDH - Mus musculus: D-lactate dehydrogenase Homo sapiens: PC16G05080 cerevisiae: PC12G01020 thaliana: hypothetical mating-type PC22G19370 oxidoreductase [+ 6 isozymes] oxooctadec- a [protein]- acid permease carinii: FMN ubiquinol-8 ubiquinone-9 3-amino-1- biotin synthesis cysteinylglycine an α-(γ-L- PC20G14670 (S)-3-amino-2- bicarbonate proline degradation II cerevisiae: PC12G05520 transferase SCOT dehydrogenase PC06G01040 a [protein]-L- amino acid amino acid transport dihydrofolate 5,10- L-γ- PC21G22090 dehydrogenase adhT - Bacillus PC12G06970 loci and centromere cprA - Aspergillus 11-enoyl-[acp] L-tyrosine - Neurospora PC13G03650 ubiquinone-10 1-deoxy-D-xylulose hydroxyacetone- pyridoxamine enzyme glutamyl)-L- methylpropanoate - Homo sapiens: PPP JMO2DD - proline (ω = 0) palmitate sulfate protein shst2 - sulfate flavin adenine synthetase: methenyltetrahydrofolate asp formate tetrahydrofolate 2-hexaprenyl-3-methyl- glutamylcysteine ldhA - Escherichia stearothermophilus: L-homocysteine phe silencing protein clr4p - formate 2-oxopentenoate i a thiol a ubiquitin niger [possible a protein acetate an alcohol crassa 5-phosphate 1-phosphate pyridoxine like protein amino acid [+ 3 isozymes] acetoacetate PC14G00590 a biotinylated deoxyguanosine D-ribose Macaca fuscata: D-ribose xanthine Stylosanthes tetrahydrofolate dinucleotide PC13G07660 methenyltetrahydrofolate pyridoxal 5-hydroxy-6-methoxy- cysteinylglycinase: acetyl-CoA formate coli: PC21G23650 PC22G24580 pro aromatic AMP a long-chain acyl-CoA acetaldehyde gly a [holo-acyl- Schizosaccharomyces a purine base sequencing a carboxylate folylpolyglutamate An15g01990 tyrosine degradation III methionine degradation III tryptophan degradation diphosphate a cis-delta19-3- [BCCP monomer] PC12G05320 hamata synthase Fad1 - cyclohydrolase: formate- kinase PKH - 1,4-benzoquinol PC22G11170 [+ 11 isozymes] aminotransferase carrier-protein] pombe: PC13G08920 error]: dicarboxylic synthase Fol3 - 7,8-dihydrofolate - Aspergillus (S)-malate proline oxo-C38:1-[acp] a [histone] N 6 - catechol Saccharomyces PC20G03600 α-iminosuccinate tetrahydrofolate Homo sapiens: hexaprenyldihydroxybenzoate cysteinylglycinase: folate polyglutamylation I glyoxysomal citrate I (via anthranilate) phenylalanine synthase PC21G20890 lysine permease Saccharomyces ubiquinone-8 niger: (R)-lactate arginine degradation X (arginine dehydrogenase I Aro8 - acetoacetyl-CoA succinate methyl-L-lysine amino acid cerevisiae: glycine ligase: PC22G25550 methyltransferase: PC22G12370 PC18G03470 synthase - Cucurbita isobutanol transaminase: a reduced a proteinogenic a proteinogenic Lyp1 - cerevisiae: 10-formyl- pantothenate biosynthesis I PC20G13420 glutamate- fumarate hydratase monooxygenase pathway) tyr met slgA -Drosophila Saccharomyces permease Dip5- lys lys PC21G20930 decarboxylase PC20G03600 sp: PC12G00660 trp PC12G11860 hemoprotein amino acid amino acid Saccharomyces PC22G17760 dihydrofolate tetrahydrofolate pyridoxamine cysteine tetrahydrofolate fumR - Rhizopus melanogaster: cerevisiae: Penicillium reductase subunit H pyridoxine-5'-phosphate ubiquinol-6 7,8- acetaldehyde CO H indoleamine 2,3- PC12G11860 chrysogenum 5'-phosphate ligase: oryzae: PC22G23810 acetylphosphate 2 2 PC21G19930 cerevisiae tetrahydrofolylpolyglutamate FAD 2-oxoisovalerate like protein diaminopelargonate cys gly citrate arg coenzyme A DHFR - phosphoribosylglycinamide formyltetrahydrofolate PC13G15380 2-oxo-4- dioxygenase IDO phenylpyruvate synthase Met7 - quinolinate An08g04390 dethiobiotin cytoplasmic serine formate- hypothetical protein alcohol dehydrogenase 4-hydroxyphenylpyruvate (S)-1-pyrroline-[+ 2 isozymes] a cis,cis- a (9Z)-3- a trans-delta2- biosynthesis Pneumocystis formyltransferase 3-methyl-2-oxobutanoate deformylase purU pyridoxal acetate kinase like methylthiobutanoate - Mus musculus: γ a cis-delta19- a cis-delta9- 2-aminoadipate- (2E,6E)-farnesyl (2E,6E)-farnesyl β dicarboxylic high affinity - Aspergillus 10-formyl- pyridoxamine- pyridoxamine- hydroxymethyltransferase tetrahydrofolate SPAC30C2.08 - mitochondrial aconitate 5-carboxylate 2-oxo acid oleate NADPH A 2-oxoglutarate -butyrobetaine a malonyl-[acp] a malonyl-[acp] spermine OPC-8:0 D-nopaline L-carnitine ATP GDP oxooctacos- -D-glucose an alcohol Saccharomyces carinii: Ade8 -Saccharomyces hydroxymethyltransferase - Corynebacterium synthetase: protein An02g06420 adh1p - glutamine glutamate PC22G11860 C38:1-[acp] C28:1-[acp] inosine 6-semialdehyde delta17,35-3- diphosphate cis,cis-delta17,35- diphosphate amino acid nickel nicotinate-nucleotide niger: tetrahydrofolate phosphate phosphate Shm2 - Saccharomyces ligase: Schizosaccharomyces hydratase Aco1 - N-formylkynurenine decarboxylase: 12-oxophytodienoate carnitine O- 9-enoyl-[acp] cerevisiae:tetrahydrofolate- PC13G07660 (R)-pantothenate PC13G03650 cerevisiae: PC22G21160 panB - Aspergillus sp: PC20G01960 PC20G13420 - Aspergillus niger: Schizosaccharomyces degradation I 4-guanidinobutyramide dependent delta-1-pyrroline- alanine degradation II (to D-lactate) citrulline degradation aminoadipate oxo-C54:2-[acp]NADPH- aristolochene NADPH- C54:3-[acp]enoyl aristolochene glucose acarbonyl proteinogenic permease Dip5 - a proteinogenic Ni 2+ transporter Ni 2+ pyrophosphorylase PC12G15080 methenyltetrahydrofolate oxidase Pdx3 - oxidase Pdx3 - pyridoxal ubiquinone-6 cerevisiae: PC13G05010 PC20G03600 a tetrahydrofolate pombe: PC13G03060 Saccharomyces pombe: PC12G13440 acid resistance PC12G11870 reductase opr - acetyltransferase reductase oxidase reductase amino acid amino acid L-glutamate pantothenate nidulans: PC16G10000 cytoplasmic serine PC18G00650 (R)-acetoin biosynthesis II 5-carboxylate Degradation/Utilization/Assimilation - Other dependent synthase Ari1 dependent reductase of synthase Ari1 Saccharomyces - Ralstonia (carboxylating) cyclohydrolase: Saccharomyces Saccharomyces kinase PKH - dethiobiotin cerevisiae: PC22G02000 amidase - (4-hydroxyphenyl) arylformamidase: long-chain-fatty-acid- hypothetical NADPH gamma- polyamine Lycopersicon cat2 - Candida nucleoside- enzyme lys2 - precursor (NADPH) S1 kinase panK hydroxymethyltransferase trifunctional C1- cytoplasmic serine folylpolyglutamate fumarate [+ 11 isozymes] gln 3-methylthiopropanal dehydrogenase phenylacetaldehyde hypothetical 3- hypothetical 3- D-nopaline beta-ketoacyl - Penicillium beta-ketoacyl the lovastatin - Penicillium cerevisiae eutropha NAD salvage tetrahydrofolate 3-methyl-2-oxobutanoate QPRTase - PC20G03600 cerevisiae: cerevisiae: Homo sapiens: glt 5-oxoproline 10-formyl- mitochondrial acetate Rhodococcus acetaldehyde glt PC22G06360 -CoA ligase Faa2 dehydrogenase Oye3 butyrobetaine oxidase PAO esculentum: inosine-uridine tropicalis: diphosphate Acremonium goxC - - Candida - Aspergillus Shm2 - Saccharomyces tetrahydrofolate biotin hydroxymethyltransferase synthase Fol3 - glutaminase p5cdh - Homo ala L-citrulline octane oxidation oxoacyl-(acyl- oxoacyl-(acyl- dehydrogenase reductase RhlG roqueforti: reductase RhlG biosynthesis roqueforti: pathway III hydroxymethyltransferase Homo sapiens: PC21G10250 PC21G10250 PC22G25550 tetrahydrofolate aconitase hydroxylase ethanol pyruvate sp: PC22G02210 glutamate glutathione-mediated - Saccharomyces - Saccharomyces hydroxylase - -Zea mays: PC22G06210 nucleosid PC20G15010 kinase NDK-1 chrysogenum: Aspergillus magnoliae: folate nidulans: cerevisiae: PC13G05010 synthase Ade3 - 5,10- synthase Bio2 - Shm2 - Saccharomyces Saccharomyces A gtaA - thermostable alcohol thermostable alcohol sapiens: thermostable alcohol ornithine alkylnitronates carrier-protein) carrier-protein) nos - - Pseudomonas PC21G10770 - Pseudomonas lovC - PC21G10770 nicotinamide panB - Aspergillus PC20G08420 Aco1 - Saccharomyces acetolactate synthase [+ 12 isozymes] decarboxylase kynurenine detoxification cerevisiae: PC12G05520 cerevisiae: PC20G12840 Pseudomonas PC18G02250 hydrolase - Neurospora PC20G02260 niger [putative PC22G09490 dicarboxylic transporter/ PC20G02220 Saccharomyces methenyltetrahydrofolate S-adenosyl-L-methionine cycle II Saccharomyces cerevisiae: PC12G16020 cerevisiae: Aspergillus dehydrogenase dehydrogenase PC21G19920 dehydrogenase carbamoyltransferase degradation synthase synthase 12-oxophytodienoate Agrobacterium carnitine acetyl aeruginosa: aeruginosa: Aspergillus riboside a tetrahydrofolate D-4'- nidulans: PC12G08040 nicotinate cytoplasmic serine cerevisiae: PC13G03110 precursor ALS - GAD1 - alanine transaminase n-octane acyl-CoA synthase like hypothetical NADPH sp: PC13G02700 polyamine IUNH - Crithidia crassa: aristolochene aristolochene sequencing amino acid folate carrier folate cerevisiae: 5-formyltetrahydrofolate pyridoxal-P cerevisiae: PC22G17760 oryzae: adhT - Bacillus adhT - Bacillus [+ 2 isozymes] kynureninase adhT - Bacillus argB - Aspergillus niger T32M21.120 T32M21.120 reductase opr - tumefaciens: transferase facC L-aminoadipate- PC22G03680 PC22G03680 terreus: a[+ proteinogenic 2 isozymes] a proteinogenic phosphopantothenate mononucleotide hydroxymethyltransferase succinate Schizosaccharomyces 4-guanidinobutyrate Arabidopsis ALA2 - Hordeum RX ethylnitronate protein An18g03800 dehydrogenase Oye3 gamma- oxidase PAO fasciculata: PC21G15880 synthase Ari1 synthase Ari1 error]: permease Dip5 - AAG37834.1 - 2-dehydropantoate PC20G03600 cyclo-ligase MTHFS PC20G13470 5,10- 10 PC13G02130 stearothermophilus: stearothermophilus: - Rattus stearothermophilus: [putative sequencing -Arabidopsis -Arabidopsis Lycopersicon PC22G06570 - Aspergillus semialdehyde PC14G00090 a ketone amino acid amino acid Shm2 - Saccharomyces an N - tetrahydrofolylpolyglutamate cis-aconitate pombe: PC22G23110 vulgare: PC12G09430 - Aspergillus niger: - Saccharomyces -Zea mays: a cis,cis-[+ 5 isozymes] - Penicillium a cis-delta9-3-[+ 5 isozymes] a cis,cis- - Penicillium Saccharomyces Homo sapiens nicotinamide 5,10-methenyl- - Homo sapiens: met methylenetetrahydrofolate PC22G24580 PC22G24580 thaliana: glt norvegicus: PC22G24580 error]: PC22G18390 alkane 2-nitropropane butyrobetaine thaliana: thaliana: esculentum: PC13G11080 nidulans: dehydrogenase PC21G10930 folylpolyglutamate ketopantoate reductase cerevisiae: PC12G16020 NAD-dependent 5,10- formyltetrahydrofolate synthase Met7 - pyruvate fermentation [+ 2 isozymes] [+ 3 isozymes] PC22G00970 carbamoyl- glutathione S- PC13G01890 cerevisiae: PC16G11690 hydroxylase BBH PC12G08750 delta17,35-3- roqueforti: hydroxyC28:1- delta17,35- roqueforti: cerevisiae mononucleotide tetrahydropteroyl- PC20G01330 9-mercaptodethiobiotin hydroxylase: dioxygenase PC12G06970 PC12G06970 PC21G12880 PC13G13280 + [+ 2 isozymes] synthase Fol3 - NAD/NADH phosphorylation and dephosphorylation Saccharomyces mitochondrial aconitate to ethanol II (S)-2-acetolactate glt [+ 11 isozymes] [+ 11 isozymes] PC22G20570 [+ 11 isozymes] phosphate transferase ADP H large subunit hydroxyC54:2- PC12G06310 [acp] C54:2-[acp] PC12G06310 Cu(2+)- [γ-Glu] R-4'- apbA -Salmonella methylenetetrahydrafolate folylpolyglutamate [+ 2 isozymes] PC14G01030 ncd-2 - - Homo sapiens: 12-oxo-cis-10,15- 2-oxoglutarate GTP D-glucono- nicotinamide Saccharomyces (n) nicotinate adenine 5-formyl- S-adenosyl-L-methionine cycle I ATP- hydratase Aco1 - pyruvate omega - arg O-acetylcarnitine Lys2-Penicillium transporting phosphopantothenoyl- typhimurium: PC20G07610 5-methyl- 5,10- dehydrogenase Mtd1 biotin synthase Fol3 - cerevisiae: PC13G07660 tyrosol methionol 4-aminobutyrate glt anthranilate 2-phenylethanol Neurospora PC12G00050 phytodienoate D-ribose [acp] 5-epi-aristolochene aristolochene 1,5-lactone dicarboxylic mononucleotide cerevisiae: dinucleotide tetrahydrofolate hydrolyzing 5- Saccharomyces pyruvate alpha-acetolactate 4-aminobutyrate L-cysteine + + propane- 1-(3-aminopropyl) chrysogenum: + -Saccharomyces 5-methyltetrahydropteroyltriglutamate- synthase Bio2 - a 5,10- Saccharomyces Activation/Inactivation/ Sus scrofa: AMP oleoyl-CoA diphosphate H A(H2) NADP a [holo-acyl- a [holo-acyl- hypoxanthine amino acid 2+ P-type ATPase 2+ L-cysteine NAD β tetrahydrofolate methylenetetrahydrofolate D-lactate crassa: a cis-delta21-3- a cis-delta11-3- Cu Cu adenylyl PC22G17760 -alanine L-pantoate oxoprolinase a tetrahydrofolate cerevisiae: PC22G02000 pyruvate decarboxylase decarboxylase aldB degradation II an oxidized PC22G04890 carrier-protein] carrier-protein] 1,3-diamine -4-aminobutanal Lys2 a proteinogenic a proteinogenic like protein NAD+ cerevisiae: PC12G03360 SAM phosphatidylethanolamine -homocysteine S-methyltransferase Saccharomyces methylenetetrahydrofolate cerevisiae: Interconversion dehydrogenase glutamate octanol PC22G11480 oxo-C40:1-[acp] oxo-C30:1-[acp] permease Dip5 - transferase 10 - Rattus mitochondrial dcpY - Aspergillus - Bacillus brevis: amino acid amino acid An01g08110 - tetrahydrofolylpolyglutamate an N - synthetase, methylenetetrahydrofolate methyltransferase cho2p Met6 - Saccharomyces cerevisiae: PC22G17760 L-serine degradation dehydrogenase Gdh2 CO rubredoxin [+ 10 isozymes] L-carnitine succinate synthase synthase 2-aminoadipate Saccharomyces NMNAT - S-adenosylmethionine norvegicus: folylpolyglutamate DIMBOA-glucoside parasiticus: PC18G01490 PC20G11450 ldhA - Escherichia 2 [+ 2 isozymes] synthase Met7 - formyltetrahydrofolate 40 kD subunit of mitochondrial folate glutamine reductase (NADPH) - Schizosaccharomyces cerevisiae: PC22G18630 PC20G13470 aconitase hydroxylase asparagine cys - Saccharomyces cerevisiae Aspergillus niger Homo sapiens: pantoate--beta- synthase eth-1 - PC22G23330 synthase Fol3 - tetrahydrofolylpolyglutamate Fatty Acid and Lipid Biosynthesis degradation coli: PC21G23650 a glutathione- nitrite Saccharomyces NADH-ubiquinone nicotinamide polyglutamylation II dependent: Met12 -Saccharomyces pombe: PC21G02080 Aco1 - Saccharomyces [+ 3 isozymes] degradation I holocytochrome- glutamate degradation I cerevisiae: PC22G08300 Na+-H+ PC12G08660 4'-phosphopantetheine alanine ligase panC thioredoxin pathway S-adenosylmethionine Neurospora crassa: Saccharomyces synthase Met7 - acetaldehyde (R)-acetoin S-conjugate cerevisiae: PC13G07660 reductase NUO-40 - nucleotide NAD kinase: PC21G16060 cerevisiae: PC21G15910 biotin [+ 2 isozymes] cerevisiae: PC13G03110 c synthase cyt- ser (R)-lactate hypothetical antiporter - Corynebacterium synthase eth-1 - phosphatidyl-N- PC16G04380 cerevisiae: Saccharomyces palmitate biosynthesis DIMBOA-Glc ammonia 1-octanal a dolichyl β- N-acetyl-D- cis-coumarinic a [protein] C- 2-aminoadipate- a cis,cis- a trans-delta2- a trans-delta2- a trans-delta2- + Neurospora crassa: transhydrogenase PC21G08600 a folylpolyglutamate β + + (n) palmitate biosynthesis II (bacteria and plants) superpathway of triacylglycerol biosynthesis fatty acid biosynthesis asn 2 - Neurospora L-serine dehydratase a reduced an acyl-[acyl- a (7Z)-hexacos- a (3Z)-docos- a (4Z)-hexadec- isopenicillin N agmatine -D-glucose Rh neutral amino Na like protein Na NAD glutamicum [putative NAD + an oxidized methylenetetrahydrofolate Neurospora crassa: methylethanolamine PC22G17760 cerevisiae: PC13G07660 I (animals) cholesterol biosynthesis I beta-glucosidase D-threo-isocitrate alcohol dehydrogenase Detoxification a protein D-mannosyl a malonyl-[acp] a malonyl-[acp] a malonyl-[acp] galactosamine- acid-β-D-glucoside L-ornithine terminal glycine 6-semialdehyde delta13,25-3- a protein cis,cis-delta7,25- cis,cis-delta13,31- cis-delta15- a proteinogenic a proteinogenic PC22G01610 NNTM - Bos taurus: ergosterol biosynthesis initiation II L-asparaginase II crassa: glt Cha1 - Saccharomyces rubredoxin carrier protein] a 2-lysophosphatidate 7-enoyl-[acp] 3-enoyl-[acp] 4-enoyl-[acp] acid permease An17g01550 - sequencing error]: reductase Met13 N-methyltransferase 10 precursor BGLUC adh1p - aldehyde phosphate 6-phosphate L-aminoadipate- oxo-C44:2-[acp] C44:3-[acp] C50:3-[acp] glucose 1- C34:2-[acp] phenylacetate a tetrahydrofolate [+ 25 isozymes] PC21G18800 thioredoxin PC16G04380 tetrahydrofolylpolyglutamate an N - AnsA -Rhizobium glutamate dehydrogenase an (L- acetylornithine NADPH- calcium/ enoyl enoyl enoyl amino acid amino acid Aspergillus niger PC21G05500 - Saccharomyces Opi3 - Saccharomyces (2E,6E)-farnesyl - Kluyveromyces precursor of Schizosaccharomyces PC22G25750 cerevisiae: PC16G03260 dehydrogenase ammonium semialdehyde dehydrogenase hydroxylase - Neurospora glutathione folylpolyglutamate synthase L-homocysteine phosphatidylethanolamine SAM synthase Met7 - formyltetrahydrofolate an acetoacetyl-[acp] an acetoacetyl-[acp] sn-glycerol-3-phosphate etli: PC16G11510 Gdh2 - Saccharomyces superoxide cysteinylglycine) aminotransferase dependent calmodulin reductase of reductase of reductase of dephospho-CoA cerevisiae: PC15G00480 cerevisiae: PC16G02100 acetyl-CoA diphosphate acetyl-CoA marxianus: mitochondrial isocitrate pombe: PC12G13440 [+ 3 isozymes] L-serine dehydratase aldA - acyl-coenzyme beta-glucosidase Gly-X proclavaminic dehydrogenase gdhIII - Bacillus pahA - crassa redox Fol3 - Saccharomyces methyltransferase cho2p Saccharomyces dehydrosqualene sn-glycerol- acetyl-CoA:ACP cerevisiae: PC22G08300 radicals degradation -S-conjugate dolichyl-phosphate-D- 1-acylglycerol- hypothetical 3- hypothetical 3- hypothetical 3- N-acetylglucosamine- arg8 - beta-ketoacyl dependent the lovastatin the lovastatin the lovastatin low affinity NADH NADP + precursor of PC22G19810 dehydrogenase [+ 11 isozymes] [+ 2 isozymes] pyruvate Cha1 - Saccharomyces Aspergillus niger: A:isopenicillin N precursor carboxypeptidase acid amidino large subunit megaterium: Penicillium reactions II (R)-pantothenate cerevisiae: PC22G17760 thioredoxin - Schizosaccharomyces cerevisiae: PC13G07660 NADPH- NADPH- synthase: 3-phosphate transacylase: 2-oxoglutarate cysteinylglycinase: mannose--protein O- 3-phosphate O- oxoacyl-(acyl- oxoacyl-(acyl- oxoacyl-(acyl- 6-phosphate Kluyveromyces reductase RhlG protein biosynthesis biosynthesis biosynthesis zinc transport met S-adenosyl-L-homocysteine acetyl-CoA C- icdA - Aspergillus asp cerevisiae: PC13G07300 superoxide PC06G00180 acyltransferase BGLUC - precursor Yscs - hydrolase pah Lys2-Penicillium PC21G04410 chrysogenum: hypothetical 2+ 2+ reductase TrxB- PC21G13930 [+ 12 isozymes] acyltransferase deacetylase lactis: PC20G14810 Zn protein Zrt2 - Zn glutathione tetrahydrofolylpolyglutamate pombe: PC21G02080 a 5,10- dependent dependent acetyltransferase - presqualene acyltransferase like PC21G10870 niger: PC20G03610 ethanol pyruvate PC18G03470 mannosyltransferase carrier-protein) carrier-protein) carrier-protein) (acyltransferase) Kluyveromyces Saccharomyces - Streptomyces - Pseudomonas kinase cmkC lovC - lovC - lovC - neutral amino Penicillium DIMBOA Cu,Zn [+ 10 isozymes] like protein CaNAG2 - chrysogenum: glucose 1- PC22G02230 Saccharomyces synthase Met7 - phosphatidyl-N- methylenetetrahydrofolate beta-ketoacyl beta-ketoacyl Rattus norvegicus: diphosphate protein An18g01960 an acetyl-[acp] Electron Transfer Chains Pmt4 - Saccharomyces synthase synthase synthase AAT/PenDE- marxianus: ornithine cerevisiae: clavuligerus: aeruginosa: - Aspergillus Aspergillus Aspergillus Aspergillus a proteinogenic acid permease a proteinogenic coenzyme A chrysogenum: superoxide an L-cysteine- An13g00040 - Candida albicans: Lys2 dehydrogenase [+ 9 isozymes] cerevisiae Saccharomyces methylethanolamine reductase RhlG reductase RhlG PC22G00420 - Aspergillus niger: 2-oxoglutarate octanoate cerevisiae: T32M21.120 T32M21.120 T32M21.120 Penicillium PC22G19810 transaminase PC20G02630 PC22G09020 PC22G03680 nidulans: terreus: terreus: terreus: amino acid - Neurospora amino acid TrxB squalene dismutase S-conjugate Aspergillus niger: PC22G10010 gdhIII - Bacillus glutathione NADPH cerevisiae: PC13G07660 N-methyltransferase - Pseudomonas - Pseudomonas PC21G05490 hypothetical 3- PC21G05160 -Arabidopsis -Arabidopsis -Arabidopsis chrysogenum: AAT otaA - aminoadipate a cis,cis-[+ 5 isozymes] PC20G01080 PC14G00090 a cis,cis-PC14G00090 PC14G00090 an alcohol crassa cytosolic synthase: a 2-lysophosphatidate aerobic respiration -- electron donor II sodC - PC20G09020 [+ 12 isozymes] [+ 2 isozymes] a cis,cis-delta7,25- megaterium: a cis-delta15- reductase Glr1 - Opi3 - Saccharomyces aeruginosa: aeruginosa: oxoacyl-(acyl- long-chain- thaliana: thaliana: thaliana: Aspergillus reductase delta13,25-3- [+ 2 isozymes] delta13,31- acetyl-CoA C- PC21G13930 Aspergillus C44:2-[acp] PC14G00340 C34:1-[acp] Saccharomyces 5-methyltetrahydropteroyltriglutamate- cerevisiae: PC16G02100 PC22G03680 PC22G03680 carrier-protein) fatty-acid--CoA a 3-O-(α-D- PC12G06970 PC12G06970 PC12G06970 D-galactosamine nidulans: Peptide enzyme lys2 - hydroxyC44:2- a phosphoprotein C50:2-[acp] a folylpolyglutamate a reduced adenosylhomocysteinase - acetyltransferase 1-acylglycerol- fumigatus: a dolichyl acetate gly D-glucono- dicarboxylic cerevisiae: (n) -homocysteine S-methyltransferase Amine and Polyamine Biosynthesis [+ 5 isozymes] [+ 5 isozymes] pentose phosphate pathway Pentose Phosphate Pathways NADH ligase Faa2 - mannosyl)-(Ser/ penicillin G 6-phosphate β-D-glucose PC18G03600 Acremonium thioredoxin Homo sapiens: PC16G05080 Erg10 - squalene plant sterol biosynthesis 3-phosphate O- synthase PC21G16940 phosphate 2-aminoadipate coumarinate putrescine urea [acp] 1,5-lactone amino acid PC16G13280 Met6 - Saccharomyces a (3R)-3- Saccharomyces an N-acetyl- Thr)-[protein] a phosphatidate L-glutamate γ- chrysogenum: a proteinogenic a proteinogenic a (3R)-3- Saccharomyces acyltransferase like T32M21.120 UQ fatty acid β-oxidation Fatty Acid and Lipid Degradation a thiol a (9Z)-3- a [holo-acyl- a (5Z)-3- a [holo-acyl- a (6Z)-3- permease Dip5 - cerevisiae: PC22G18630 hydroxybutanoyl- squalene β-D-glucose- β phospholipases [+ 2 isozymes] cerevisiae: L-cysteine- semialdehyde PC20G02260 amino acid amino acid glycine betaine hydroxybutanoyl-[acp] cerevisiae: protein An13g00040 -Arabidopsis II (core pathway) fatty acid -oxidation I hydrogen oxooctacos- carrier-protein] oxotetracos- carrier-protein] oxooctadec- Saccharomyces S-adenosyl-L-homocysteine spermidine biosynthesis I choline biosynthesis III glycine betaine putrescine biosynthesis III [acp] monooxygenase - (2E,6E)-farnesyl diphosphate 6-phosphate PC12G05520 S-conjugate glutathione L-homocysteine S-ribosyl-L-homocysteine biosynthesis I (Gram- PC22G10140 - Aspergillus niger: thaliana: peroxide 9-enoyl-[acp] synthase 5-enoyl-[acp] synthase 6-enoyl-[acp] 2-aminoadipate cerevisiae biosynthesis II (Gram- 3-hydroxyacyl- 3-hydroxyacyl- Rattus norvegicus: a (3Z)-alk-3- a 1-phosphatidyl-1D-myo- disulfide negative bacteria) acetoacetyl-CoA PC20G09020 PC12G06970 glucose-6- a fatty acid a 1,2-diacyl-sn-glycerol catalase kat - acyl-CoA positive bacteria) [acp] [acp] dehydrase: PC22G15550 dehydrosqualene phosphat 1- enoyl-CoA inositol 4,5-bisphosphate SAM phosphoryl-choline L-ornithine acyl-CoA Methanosarcina synthase hypothetical choline dehydrase: PC14G00080 (S)-2,3- synthase: PC21G13930 a phosphatidate an acetoacetyl-[acp] dehydrogenase choline-phosphate choline 3-hydroxy-3- synthase barkeri [truncated like protein β neutral amino choline ornithine decarboxylase PC14G00080 epoxysqualene gsdA - a glucosylated D- an (S)-2- N-acetyl- -D- a nucleoside a cis,cis- (S)-2- a trans-delta2- a trans-delta2- 6-O-trans- a trans-delta2- a proteinogenic a proteinogenic cytidylyltransferase thermostable alcohol methylglutaryl- like protein phospholipase D ORF][putative An18g03800 a galactosylated galactose acceptor ATP H O a (5Z)-tetracos- a cis-delta15- an acyl-[acyl- β an acyl-CoA acetone acid permease dehydrogenase ODC - Paracoccidioides a (2E)-but-2-enoyl-[acp] 40 kD subunit 2 a malonyl-[acp] a malonyl-[acp] a malonyl-[acp] -alanine dimethylglycine glucosamine RNA delta19,31-3- cis-cis-delta7- cis,cis-delta21,39- methoxy-mycolyl- cis-delta11- S-adenosylmethionine Pct1 - Saccharomyces dehydrogenase a (2E)-but- CoA synthase lanosterol presqualene diphosphate Aspergillus niger: An18g03800 - Aspergillus 5-enoyl-[acp] C34:1-[acp] carrier protein] glucose acceptor (R)-pantolactone halocarboxylate triphosphate hydroxyglutarate amino acid amino acid betA -Escherichia brasiliensis: PC21G18390 of NADH- Spo14 -Saccharomyces sequencing error]: long-chain acyl-CoA oxo-C50:2-[acp] glycolate 19-C38:3-[acp] C58:3-[acp] trehalose-6- C30:2-[acp] phenylacetate - Neurospora decarboxylase spe- cerevisiae: PC16G02430 adhT - Bacillus 2-enoyl-[acp] Erg13 - synthase erg7p - PC20G03330 - Aspergillus a (2E)-2- niger: NADPH- enoyl enoyl enoyl coli [truncated fatty-acyl-CoA synthase ubiquinone cerevisiae: PC21G01360 PC23G00900 dehydrogenase like oxidase GOX - phosphate hydroxylase crassa 2 - Neurospora CDP-choline stearothermophilus: ornithine decarboxylase Saccharomyces Schizosaccharomyces squalene synthase: 6-phospho- niger: enoyl-CoA PC13G01890 peptidoglycan dependent reductase of reductase of trehalose-6- reductase of isoleucine biosynthesis I Amino Acid Biosynthesis ORF]: PC22G09460 enoyl-[acyl- beta chain fas1p - a 1,2-diacyl-sn-glycerol reductase NUO- [+ 2 isozymes] triacylglycerol [+ 6 isozymes] beta-galactosidase ciliary dynein beta heavy beta-glucosidase protein An04g03290 2-haloacid Mus musculus: pahA - superpathway of leucine, valine, and isoleucine biosynthesis lysine biosynthesis IV glycine alanine arginine biosynthesis II (acetyl cycle) proline biosynthesis I hypusine crassa: PC21G01250 PC22G24580 ODC - Paracoccidioides cerevisiae: pombe: PC22G14100 PC21G13930 D-glucono- PC13G01890 mitochondrial a phosphatidylcholine a phosphatidate hypothetical 3- hypothetical 3- hypothetical 3- pantoate--beta- dimethylglycine GlcNAc RNA- beta-ketoacyl the lovastatin the lovastatin phosphate the lovastatin arginine biosynthesis I histidine biosynthesis cysteine biosynthesis IV (fungi) threonine carrier-protein] Schizosaccharomyces 40 - Neurospora degradation lacA - Aspergillus chain - Anthocidaris precursor - Aspergillus niger: halidohydrolase PC22G19270 Penicillium hypothetical biosynthesis II biosynthesis II biosynthesis choline brasiliensis: PC13G07510 PC18G01450 1,5-lactone enoyl-CoA O AMP oxoacyl-(acyl- oxoacyl-(acyl- oxoacyl-(acyl- alanine ligase panC dehydrogenase deacetylase directed RNA reductase RhlG biosynthesis biosynthesis phosphatase biosynthesis biosynthesis [+ 11 isozymes] reductase: pombe: PC21G10870 lanosterol diacylglycerol CDP-diacylglycerol crassa: 2 niger: PC14G01510 crassispina: PC21G06900 BGLUC - IVa - Burkholderia oxaloacetate 5-phospho- dehydrogenase like putrescine squalene O a reduced c-type cytochrome long-chain- hydratase carrier-protein) carrier-protein) carrier-protein) - Corynebacterium PC16G07560 precursor PgdA - polymerase glycolate like protein chrysogenum: neutral amino pyruvate S-adenosyl-L- betaine aldehyde PC14G00080 acyltransferase biosynthesis I 6-phosphogluconolactonase: 2 a triacyl-sn Kluyveromyces cepacia: - Pseudomonas lovC - lovC - lovC - Aspartate thr ATP α 2-oxoglutarate N-acetylglutamyl-phosphate glt an [eIF5A- fatty-acyl-CoA synthase 3-hydroxy-3- synthase erg7p - PC22G01610 fatty-acid--CoA secreted beta- cytoplasmic dynein like protein oxidase GOX - An11g10990 PC22G02230 acid permease glt -D-ribose 1- ammonia CO pyruvate L-homoserine oxaloacetate protein An16g05660 methioninamine squalene monooxygenase DAGAT - PC20G03330 ECHS1 calcium-independent -glycerol synthase synthase synthase marxianus: glutamicum [putative long-chain acyl-CoA DMGDH - PC22G05490 Streptococcus aeruginosa: Aspergillus Aspergillus Aspergillus transaminase: homocitrate 2 glutamate 5- precursor]-lysine putrescine a phosphatidylcholine beta chain fas1p - methylglutaryl- Schizosaccharomyces dihydroxyacetone [+ 25 isozymes] ligase Faa2 - a 2,3,4- triacylglycerol galactosidase light chain dlc1p - An11g09540 Mus musculus: - Aspergillus [+a 9proteinogenic isozymes] - Neurospora a proteinogenic acetolactate synthase diphosphate alanine Aspartate deoxyhypusine - Aspergillus niger: betaine-aldehyde a butanoyl-[acp] -Rattus norvegicus: Arabidopsis thaliana: 6-phospho- - Rattus phospholipase A2 - Homo T32M21.120 T32M21.120 T32M21.120 PC22G19810 sequencing error]: dehydrogenase like Homo sapiens: pneumoniae: PC22G03680 terreus: terreus: terreus: PC16G02790 threonine synthase lys1- acetylglutamate kinase/ kinase Pro1 - Schizosaccharomyces CoA synthase pombe [putative phosphate Saccharomyces acyl-CoA saturated (3R)-3- lipase lipI - lacA - Aspergillus Schizosaccharomyces [+ 3 isozymes] - Aspergillus PC18G01590 niger: amino acid crassa amino acid precursor ALS - amino-acid N- transaminase transaminase: synthase - PC13G13730 dehydrogenase PC22G15550 PC13G01800 D-gluconate norvegicus: sapiens: PC21G00340 -Arabidopsis -Arabidopsis -Arabidopsis PC21G05500 protein An13g03940 PC13G04270 PC22G12060 [+ 5 isozymes] PC14G00090 a cis,cis-PC14G00090 PC14G00090 acetol deaminase ATP Penicillium glycine N-acetyl-gamma- Saccharomyces spermidine phospholipase D pombe: PC14G00740 Erg13 - sequencing error]: cerevisiae: synthase hydroxyacyl-CoA Geotrichum niger: PC06G00600 pombe: PC16G03290 [+ 12 isozymes] niger: a cis,cis- trehalose-PC20G08480 [putative [+ 6 isozymes] Schizosaccharomyces acetyltransferase - ALA2 - serine O- PC16G02790 Neurospora betaine aldehyde betB - Escherichia hypothetical 3- PC22G21270 [+ 6 isozymes] thaliana: thaliana: thaliana: - Aspergillus niger: 2-oxoglutarate a cis,cis-delta7,19- delta21,39- a cis-delta11- ILV - Arxula phosphoribosyltransferase chrysogenum: decarboxylase glutamyl-phosphate cerevisiae: synthase Spe3 - Spo14 -Saccharomyces Saccharomyces PC06G01230 diacylglycerol decarboxylating PC12G05520 like protein a phosphatidylcholine a 1-acyl-2-lyso-glycerophosphocholine candidum: PC20G02950 delta19,31-3- trans-methoxy- sequencing asp pombe: PC22G23110 Neurospora crassa: Hordeum acetyltransferase [+ 6 isozymes] crassa: coli: PC22G10030 oxoacyl-(acyl- (S)-2,3-epoxysqualene sn-glycerol- a 2,3,4-saturated a 2,3,4- PC12G06970 PC12G06970 PC12G06970 PC12G08530 a halide an (R)-2- C38:2-[acp] C58:2-[acp] C30:1-[acp] adeninivorans: his1p - Schizosaccharomyces lys1 subunit H reductase precursor PC13G05350 betaine-aldehyde Saccharomyces cerevisiae: PC21G01360 a butanoyl-[acp] cerevisiae: acyltransferase phosphogluconate An18g03800 PC22G00570 a non D-glucosamine hydroxyC50:2- mono-mycolate error] PC15G00060 vulgare: cysA - Aspergillus PC21G14310 lanosterol fatty acyl CoA a 2-enoyl-CoA saturated (3S)-3- β a non galactosylated + β (R)-pantothenate a 2-enoyl-CoA formaldehyde hydroxyacid acetate [+ 2 isozymes] pombe [putative sequencing (R)-homocitrate arg-6 - Neurospora asp L-glutamate- an [eIF5A- dehydrogenase [+ 2 isozymes] glycine betaine carrier-protein) PC12G01730 3-phosphate dehydrogenase like -D-galactose ADP phosphate H -D-glucose glucosylated D- sarcosine [acp] hypothetical aspartate PC23G00640 like protein PC12G09430 nidulans: cerevisiae: cycloartenol synthase: DAGAT - - Aspergillus hydroxyacyl-CoA [+ 13 isozymes] galactose acceptor N-acetyl-L- error]: PC21G08820 crassa: PC22G23250 5-phosphate precursor]- betB - Escherichia PC13G12400 synthase hypothetical 3- Arabidopsis thaliana: sn-glycerol- protein An11g06120 14 kD subunit niger: a diglyceride a (7Z)-3- a [holo-acyl- a [holo-acyl- glucose acceptor RNA neutral amino kinase Hom3 - (S)-2-acetolactate [+ 3 isozymes] homoaconitate An08g04390 PC22G16570 choline (S)-3-hydroxy-3- PC22G14100 subunit VIIc of 3-hydroxyacyl- hypothetical phosphatidic a cis-delta17-3- a proteinogenic a proteinogenic glutamate ala aspartate glutamate-5- deoxyhypusine coli: PC22G10030 T32M21.120 oxoacyl-(acyl- PC13G04400 3-phosphate -Aspergillus niger: of ubiquinol-- PC13G01890 oxohexacos- carrier-protein] carrier-protein] a 3-oxoacyl-[acp] acid permease - Aspergillus acetylglutamate kinase/ methylglutaryl-CoA cytochrome c + acid-preferring oxo-C36:1-[acp] amino acid amino acid Saccharomyces phosphoribosyl- hydratase lYSF acetylglutamate kinase/ homoserine O- kinase Hom3 - S-methyl-5'- -Arabidopsis cytochrome c NAD CoA 7-enoyl-[acp] synthase synthase - Neurospora ketol-acid 2-oxobutanoate acetylglutamate niger: N-acetyl-gamma- semialdehyde spermidine carrier-protein) α cycloartenol acyltransferase PC19G00410 oxidase - Bos a (2E)-2- phospholipase A1 cerevisiae: ATP - Aspergillus N-acetyl-gamma- acetyltransferase hydrogen sulfide Saccharomyces glycine betaine thioadenosine thaliana: hydroxymethylglutaryl- 4,4-dimethyl-14 - a triacyl-sn-glycerol reductase Qcr7 - long-chain- dehydrogenase crassa reductoisomerase kinase/N-acetyl- PC12G15080 glutamyl-phosphate dehydrogenase: synthase like protein decarboxylating primigenius enoyl-CoA B14D6.220 -Neurospora sphingosine and sphingosine- PC20G00640 acetolactate synthase phosphoribosyl-ATP nidulans: glutamyl-phosphate metE - Aspergillus cerevisiae: PC12G06970 coenzyme A hydroxymethyl- S-adenosyl-L- Saccharomyces fatty-acid--CoA hmgA - Sulfolobus ilv-2 - Neurospora gamma-glutamyl- amino-acid N- reductase precursor PC13G05350 an [eIF5A]- T32M21.120 α An18g01960 - phosphogluconate taurus: crassa: PC21G02950 1-phosphate metabolism a tRNA 1D-myo- succinate a (1->4)- a cis,cis- a trans-delta2- a trans-delta2- a protein a trans-delta2- precursor ALS - pyrophosphatase: PC16G06870 reductase precursor nidulans: PC20G00640 methionine biosynthesis II reductase hmg1p - 5 -cholesta- methionine:delta24-sterol- cerevisiae: mitochondrial ligase Faa2 - solfataricus: a 2-acylglycerol fructose-1-phosphate arachidoyl-CoA a cis-delta13- queuine carbonic acid H NADP + linamarin tRNA uridine L-canavanine a kanamycin dicarboxylic L-aspartyl- crassa: γ a 3-oxohexanoyl- -Arabidopsis Aspergillus niger: succinate a fatty acid a malonyl-[acp] a palmitoleoyl-[acp] a malonyl-[acp] a malonyl-[acp] containing 2 inositol (1)- α-D-glucan delta19,37-3- cis,cis-9,21- cis,cis-delta13,25- with incorrect cis-delta17- Schizosaccharomyces phosphate acetyltransferase - arg-6 - Neurospora arg-6 - Neurospora PC21G18210 L-glutamate - hypusine Schizosaccharomyces 8,24-dien-3β-ol dehydrogenase like PC22G18340 enoyl-CoA Saccharomyces PC19G00460 hypothetical phosphatidic a sphingosine- C32:1-[acp] semialdehyde 4-phosphate PC13G15810 reductase PC16G14140 cis-homoaconitate gly Neurospora crassa: [acp] thaliana: C-methyltransferase - PC21G05490 PC22G17890 guanine monophosphate succinate- tRNA- oxo-C56:2-[acp] C40:3-[acp] C44:3-[acp] disulfide bonds C36:2-[acp] kanamycin amino acid pombe: PC22G23110 crassa: PC22G23250 crassa: PC21G10800 L-aspartyl- semialdehyde pombe: PC18G05230 protein An11g06120 [+ 6 isozymes] hydratase cerevisiae: [+ 2 isozymes] acid-preferring containing inositol NADPH- enoyl enoyl protein enoyl a proteinogenic a proteinogenic 2,3-dihydroxy-3- precursor arg- phosphoribosyl- PC15G00060 L-homoserine Metabolic Regulator Biosynthesis PC12G06970 Glycine max: PC21G10300 [+ 4 isozymes] semialdehyde pseudouridine kinase type permease Dip5 - aspartate- 4-phosphate 3-oxoacyl- -Aspergillus niger: ECHS1 PC12G05520 phospholipase A1 ceramide fructose-1,6-bisphosphate NADP-reducing beta-glucosidase monophosphatase alpha-1-6- dependent arginase argA reductase of reductase of disulfide reductase of amino acid amino acid methylbutanoate [+ 2 isozymes] 6 - Neurospora AMP homoaconitate glt N-acetyl-L-glutamate N-acetyl-L-glutamate 5-semialdehyde O-acetyl-L- homoserine kinase 3-hydroxy-3- sterol transmethylase a 2-lysophosphatidate a 2,3,4-saturated a 2,3,4-saturated hypothetical carbonic dehydrogenase synthase I Pus1 - like protein Saccharomyces semialdehyde 2-aceto-2- (acyl-carrier- PC12G08920 - Rattus B14D6.220 - Neurospora alkaline aldolase - Thermus hypothetical 3- hypothetical 3- hypothetical 3- queuine tRNA- hydrogenase D precursor qutG - Aspergillus glucosidase beta-ketoacyl -Aspergillus the lovastatin the lovastatin isomerase the lovastatin crassa: phosphoribosyl- hydratase lYSF gln homoserine aspartate- Thr1 -Saccharomyces citrulline-nitric oxide cycle a 3-oxohexanoyl-[acp] methylglutaryl 4,4-dimethyl- ERG6 - Candida fatty acyl CoA 3-oxoacyl-CoA anhydrase SPBP8B7.05c NAD(P)+ gabD Saccharomyces An15g02610 cerevisiae dehydrogenase dihydroxy-acid hydroxy- protein) α 1-acylglycerol- D-ribulose- norvegicus: crassa: PC13G05490 ceramidase Ypc1 a 1-monoglyceride aquaticus: PC20G09750 oxoacyl-(acyl-carrier- oxoacyl-(acyl- oxoacyl-(acyl- ribosyltransferase chain like protein BGLUC - nidulans: glcA - reductase RhlG niger: biosynthesis biosynthesis A pdiA - biosynthesis PC22G23250 AMP - Aspergillus semialdehyde cerevisiae: PC20G00870 coenzyme 14 -formyl- albicans: PC12G14840 a phosphatidylcholine a 1-lysophosphatidylcholine - Schizosaccharomyces - Escherichia cerevisiae: - Aspergillus Hom2 - dehydratase Ilv3 butanoate acetylornithine (S)-1-pyrroline- reductase α 3-phosphate O- 5-phosphate PC22G21270 -Saccharomyces protein) synthase carrier-protein) carrier-protein) like protein An01g07240 - Kluyveromyces PC14G00790 Aspergillus - Pseudomonas PC13G09710 lovC - lovC - Aspergillus lovC - cyclohydrolase: nidulans: arginine-specific dehydrogenase O-phospho-L-homoserine 3-oxoacyl-(acyl- A reductase 5 -cholesta- fructose-bisphosphate pombe: PC22G06300 coli [putative PC13G04330 niger: hypothetical Saccharomyces - Saccharomyces N-acetylglutamyl- aminotransferase O-acetylhomoserine 5-carboxylate fabG - Bacillus β 24-methylenecycloartenol acyltransferase a 2,3,4- peroxisomal cerevisiae: T32M21.120 - synthase synthase An14g00580 - Aspergillus niger: marxianus: parasiticus: aeruginosa: Aspergillus Aspergillus niger: Aspergillus ketol-acid PC16G14140 PC16G06870 carbamoyl-phosphate Hom2 - arg carrier-protein) HmgA - 8,24-dien-3 -ol coenzyme A aldolase Fba1 - carbonic anhydrase inositol sequencing error]: PC16G11130 neutral amino cerevisiae: cerevisiae phosphate arg8 - Kluyveromyces (thiol)-lyase cysD - pyrroline-5- subtilis: like protein ribose 5- saturated (3S)-3- acetyl-CoA C- PC21G15720 Arabidopsis thaliana: T32M21.120 T32M21.120 Aspergillus niger: PC22G05110 PC22G19810 PC22G07880 pseudouridine PC22G03680 terreus: terreus: PC22G14570 terreus: a proteinogenic a proteinogenic reductoisomerase synthase subunit Cpa2 tryptophan biosynthesis Saccharomyces reductase fabG - Sulfolobus ribulose-5- succinate phospholipase C type fatty acid ω-oxidation Saccharomyces pca1 - Porphyridium monophosphatase PC21G22330 a kanamycin acid permease PC20G02910 [putative phosphoribosylformiminoAICAR- homoisocitrate lactis: PC20G14810 Aspergillus nidulans: carboxylate PC16G12960 An13g00040 - phosphate hydroxyacyl-CoA acyltransferase PC12G06970 -Arabidopsis -Arabidopsis PC13G06450 synthase Deg1 - urea PC14G00090 PC14G00090 [+ 3 isozymes] PC14G00090 amino acid amino acid ilv-2 - Neurospora acetylglutamate - Saccharomyces cerevisiae: argininosuccinate Bacillus subtilis: solfataricus: phosphate- dehydrogenase Isc2 - Saccharomyces sphingosine glycerol cerevisiae: PC18G01220 purpureum: PC21G10590 [+ 12 isozymes] qutG - Aspergillus [+ 8 isozymes] a cis,cis-[+ 5 isozymes] L-canaline a cis,cis- a protein 3'-phosphate - Neurospora sequencing error]: phosphate PC23G00630 reductase Aspergillus niger: isomerase: H O an oxidized c-type cytochrome 3-hydroxyacyl- POT1 - Yarrowia thaliana: thaliana: [+ 6 isozymes] Saccharomyces a cis,cis-delta9,21- a cis-delta17- crassa: cerevisiae: PC22G20150 PC20G02910 [+ 5 isozymes] PC16G12960 PC16G05060 4,4-dimethyl-5-α- epimerase Rpe1 2 cytochrome b nidulans: delta19,37- delta13,25- with correct crassa L-aspartate- kinase/N-acetyl- homo-isocitrate chorismate lyase ASAL - Candida lipolytica: cerevisiae: PC22G07970 PC12G06970 PC12G06970 + cerevisiae: C40:2-[acp] C36:1-[acp] PC18G02530 PC13G15810 glutamate N- [+ 2 isozymes] P5CR - a (3R)-3- PC20G09020 - Saccharomyces PC21G20440 subunit Sdh3 - CoA an alkane a fatty acid a tRNA NADPH H PC13G08390 succinate a (1->4)- 3-hydroxy- C44:2-[acp] disulfide bonds semialdehyde gamma-glutamyl- biosynthetic dehydrogenase: arginine-specific L-cystathionine albicans: PC20G06010 [+ 5 isozymes] cholesta-8,14,24- cycloeucalenol PC22G06820 [+ 3 isozymes] an (11Z)-3-oxooctadec- acetone β-D-glucose α-D-glucose PC13G14530 acetyltransferase L-aspartate- Zalerion hydroxyhexanoyl- (R)-mevalonate β cerevisiae: Saccharomyces dehydrogenase sophorosyloxydocosanoate dihydroxyacetone phosphate D-glyceraldehyde containing CO H O α-D-glucan C56:2-[acp] dihydroxy-acid 2,3-dihydroxy- phosphate enzyme HisA anthranilate trien-3- -ol ribose-5- a phosphatidylcholine a 1,2-diacyl-sn-glycerol 11-enoyl-[acp] guanine 2 2 cyanohydrin myo-inositol tRNA hypothetical homoserine PC18G05890 carbamoyl-phosphate Arg7 - Saccharomyces semialdehyde arboricola: [acp] a (3R)-3- a phosphatidate hmgA - Sulfolobus degradation [+ 3 isozymes] GUN anticodon dehydratase 3-methylvalerate reductase like protein synthase cystathionine beta- L-arginino-succinate L-citrulline PC12G00550 phosphate cerevisiae: a 2,3,4-saturated ω a 3- a [holo-acyl- pseudouridine neutral amino dehydrogenase synthase subunit Cpa2 cerevisiae: PC22G15960 PC22G23710 3-hydroxyacyl- hydroxyhexanoyl-[acp] mevalonate solfataricus: sphingosine- an -hydroxy coenzyme A a cis-delta15-3- with quenosine like protein precursor arg- An17g01640 2-oxoadipate component I Trp2 homoserine lyase metG - Aspergillus phosphatidate isomerase rpiB PC22G14260 13-sophorosyloxydocosanoate fatty acyl CoA acetyl-CoA a fatty alcohol oxodocosanoyl- carrier-protein] a proteinogenic acid permease a proteinogenic YJR139c - dihydroxy-acid - Saccharomyces [acp] kinase Erg12 - PC19G00460 1-phosphate fatty acid oxo-C34:1-[acp] at position 34 An15g06700 6 - Neurospora - Aspergillus - Saccharomyces dehydrogenase [+ 2 isozymes] nidulans: PC13G06020 3-hydroxyacyl- cytidylyltransferase D-xylulose- - Escherichia [+ 2 isozymes] 6',6''-diacetate [acp] synthase amino acid - Neurospora amino acid Saccharomyces dehydratase Ilv3 cerevisiae: PC06G02240 dehydrase: [acp] dehydrase: Saccharomyces 4,4- 5-phosphate [+ 2 isozymes] acetyl-esterase I like - Aspergillus - Saccharomyces crassa: niger: cerevisiae: YJR139c - cerevisiae: obtusifoliol Cds1 - coli: protein An07g08940 sphingosine crassa cerevisiae: niger: PC12G06840 Saccharomyces pro L-homocysteine argininosuccinate synthase PC14G00080 PC14G00080 dimethylzymosterol PC22G21440 a 2,3,4-saturated anandamide degradation cerevisiae PC22G23250 carbamoyl-phosphate L-ornithine PC22G04380 PC13G07140 Saccharomyces - Aspergillus niger: phosphate all-trans- 4-amino-5- 4-methyl-5-(β- ∆ 2 a cis,cis- a cis,cis- a trans-delta2- a trans-delta2- a (2E,7Z)- a trans-delta2- PC13G08990 Arg1 - Saccharomyces α ω a cis-delta11- a β-D-glucuronoside trans- - chitin adenosine 3',5'- PC13G02430 N-acetyl-L-ornithine L-homocysteine cerevisiae: a (2E)-hex- obtusifoliol-14 - cerevisiae: 3-oxoacyl-CoA lyase: an -oxo acetoacetate geranyl-geranyl hydroxymethyl-2- hydroxyethyl) a malonyl-[acp] a ubiquitin a 2-oxo acid L-ornithine RNA delta9,21-3- delta15,33-3- met cis,cis-5,17- cis,cis-delta17,29- hexacosa-2,7- cis-delta9- histidinol [putative acetylglutamate phosphoribulosylformimino- cerevisiae: PC12G11190 a (2E)-hex-2-enoyl-[acp] mevalonate- 13-[O(2')-β-D-glucopyranosyl-PC18G06090β-D- a fatty aldehyde C30:1-[acp] a [protein]-L-lysine decenoyl-CoA bisphosphate dicarboxylic 2-aminoadipate anthranilate PC13G08990 5-methyltetrahydropteroyltriglutamate- homocysteine S- homocysteine S- 2-enoyl-[acp] demethylase: PC12G10870 PC22G11670 D-ribose 5- peroxisomal anandamide PC22G13200 fatty acid diphosphate methylpyrimidine- thiazole oxo-C40:2-[acp] oxo-C52:2-[acp] C36:3-[acp] C48:3-[acp] dienoyl-[acp] C28:2-[acp] histidinol L-homoserine 2-oxoisovalerate sequencing error]: kinase/N-acetyl- AICAR-P 5-phosphate glucopyranosyloxy]docosanoate geranylgeranyl peroxisomal NADPH- salt tolerance NADPH- peptide enoyl enoyl enoyl enoyl amino acid cystathionine -homocysteine S-methyltransferase methyltransferase methyltransferase 4α-hydroxymethyl- α α phosphate adehydrogenase proteinogenic a proteinogenic PC18G02530 anthranilate enoyl-[acyl- fatty-acyl-CoA synthase (4 )-methyl-(5 )-ergosta- a CDP- acetyl-CoA C- O(6'')-acetate 2-trans- aldehyde pyrophosphate phosphate beta-glucuronidase 2,4-dienoyl- peptidoglycan N- dependent protein Met22 - dependent methionine reductase of reductase of reductase of reductase of permease Dip5 - gamma-glutamyl- superpathway of sulfur amino acid beta-lyase cystathionine L-homoserine Met6 - Saccharomyces AtHMT-1 - Arabidopsis AtHMT-1 - Arabidopsis phosphomevalonate 4β-methyl-5α- UQH acetoacetyl-CoA synthase transferase type 3-5 his-3 amino - acid amino acid homoserine imidazole phosphoribosyltransferase carrier-protein] beta chain fas1p - 8,14,24(28)-trien-3β-ol diacylglycerol pentose phosphate pathway (partial) 2 acyltransferase amidase - Hexadecenal dehydrogenase hypothetical 3- ornithine uidA - Escherichia CoA reductase acetylglucosamine beta-ketoacyl Saccharomyces sulfoxide Saccharomyces dihydroxy-acid phosphate biosynthesis (Saccharomyces cerevisiae) ornithine β-synthase: cerevisiae: PC22G18630 thaliana: PC22G15090 thaliana: PC22G15090 cholesta-8,24- transketolase acsA - Sinorhizobium II beta-subunit ubiquitin- exoribonuclease beta-ketoacyl the lovastatin the lovastatin the lovastatin the lovastatin kinase Thr1 - alpha- branched-chain- glycerol metG - reductase: kinase Erg8 - ∆ POT1 - Yarrowia aldA - transaminase involved in Neurospora cerevisiae dehydratase reductase carbamoyltransferase - Saccharomyces PC13G05320 homoserine Schizosaccharomyces β 14-sterol reductase: like protein fumarate Rhodococcus meliloti: PC22G00960 RABGGTB - thiamin-phosphate oxoacyl-(acyl- conjugating coli: PC16G06900 like protein deacetylase PgdA reductase RhlG cerevisiae: reductase RhlG reductase Mxr1 - biosynthesis biosynthesis biosynthesis biosynthesis ∆ 1 Aspergillus Saccharomyces dien-3 -ol lipolytica: Aspergillus niger: a dicarboxylate otaA - crassa: Saccharomyces isopropylmalate amino-acid like protein precursor arg- phosphate -piperideine- cerevisiae: PC22G05130 kinase Thr1 - met PC14G00080 pombe: PC14G00740 PC18G02000 An02g06430 D-ribulose- sp: PC22G02210 Homo sapiens: pyrophosphorylase/ carrier-protein) enzyme 2 UCE2 beta-glucuronidase sporulation Sps19 - Streptococcus - Pseudomonas PC13G06360 - Pseudomonas Saccharomyces lovC - lovC - lovC - lovC - sulfate argB - Aspergillus niger nidulans: cerevisiae: PC22G06820 13-[O(2')-β-D-glucopyranosyl-β-D- PC06G00180 acetoacetyl-CoA synthase Aspergillus An07g08320 - PC16G14140 cerevisiae: synthase Leu4 - aminotransferase An15g06700 6 - Neurospora synthase: 6-carboxylate N-(5'-phosphoribosyl) Saccharomyces enoyl - Aspergillus 5-phosphate [+ 12 isozymes] PC21G08870 hydroxyethylthiazole synthase like protein GUSB - Canis -Saccharomyces pneumoniae: aeruginosa: aeruginosa: cerevisiae: Aspergillus Aspergillus Aspergillus Aspergillus hypothetical [putative sequencing PC13G06020 fatty-acyl-CoA synthase PC21G10310 glucopyranosyloxy]docosanoate acsA - Sinorhizobium nidulans: Aspergillus niger: salt tolerance PC20G00870 Saccharomyces Bat2 - - Aspergillus crassa: PC12G06840 sulfate -anthranilate cerevisiae: reductase of 4α-methylfecosterol phosphatidylcholine biosynthesis I niger: ribulose-5- aerobic respiration -- electron donor III [+ 3 isozymes] palmitaldehyde [+ 10 isozymes] kinase Thi6 - T32M21.120 An12g07810 - lupus: PC12G11750 cerevisiae: PC20G02200 PC22G03680 PC22G03680 PC18G04330 terreus: terreus: terreus: terreus: his neutral amino error]: PC22G18390 isoleucine biosynthesis IV cysteine biosynthesis I beta chain fas1p - α β meliloti: PC13G10810 geranylgeranyl diphosphate PC18G05170 protein Met22 - a proteinogenic a proteinogenic cerevisiae: Saccharomyces adenylyltransferase mevalonate- 4 -formyl-4 - a 2,3,4-saturated Saccharomyces -Arabidopsis Aspergillus niger: PC18G03600 PC22G15030 L-methionine- PC14G00090 PC14G00090 PC14G00090 PC14G00090 acid permease O-phospho- niger: PC21G10800 PC20G00870 the lovastatin Schizosaccharomyces PC18G00660 phosphate- a fatty acid ∆ 2 ∆ 4 a cis,cis-delta9,21-[+ 5 isozymes] Saccharomyces a cis,cis-[+ 5 isozymes] a cis,cis- PC21G23240 cerevisiae: aminoimidazole D-erythro- aps-Penicillium phosphoribosylanthranilate L-cystathionine diphosphate methyl-5α- fatty acyl CoA arachidonate ethanolamine geranylgeranyltransferase I thaliana: trans- , cis- - (S)-S-oxide a cis,cis-delta5,17- a (7Z)-hexacos- a cis-delta9- amino acid - Neurospora amino acid L-homoserine PC13G02430 N-acetyl-L- biosynthesis pombe: PC21G10870 epimerase Rpe1 + cerevisiae: PC22G23780 3-hydroxyC40:2- cerevisiae: delta17,29- PC22G16780 carboxamide imidazole-glycerol- 2-aminoadipate- propionate isomerase: trpC O-phospho- cholesta-8,24- choline transketolase Tkl1 NAD beta chain GGTase-I - Rattus decadienoyl-CoA chitosan delta15,33- glutamate 5- chrysogenum: aps ser lovC - diphosphomevalonate - Saccharomyces Carboxylate Degradation + PC13G03600 PC12G06970 a proteinogenic L-glutamate γ- an alcohol D-glucuronate a nucleoside RNA acetate PC12G08170 C36:2-[acp] 7-enoyl-[acp] C28:1-[acp] crassa threonine 2-keto-3- ribonucleotide phosphate 6-semialdehyde acetyl-CoA 1-(o- holocytochrome- L-homoserine dien-3β-ol choline kinase CK1 - -Saccharomyces acetoacetyl-CoA AMP diphosphate H norvegicus: PC14G01660 [+ 16 isozymes] [acp] 3-hydroxy C48:2-[acp] (2S)-2- [+ 4 isozymes] semialdehyde Aspergillus a hexanoyl-[acp] decarboxylase Erg19 cerevisiae: UQH amino acid semialdehyde diphosphate synthase Thr4 - isopropylmalate methyl-valerate imidazoleglycerolphosphate saccharopine adenosine 5'-phosphosulfate synthetase: carboxyphenylamino) c synthase cyt- 24-methylenelophenol Glycine max: PC16G07300 cerevisiae: 2 all-trans-phytoene AMP C52:2-[acp] acetylornithine L-citrulline cystathionine threonine terreus: - Saccharomyces PC12G00550 glutaryl-CoA a [holo-acyl- hypothetical Saccharomyces branched-chain- dehydratase igh - Trichoderma PC13G05130 -1'-deoxyribulose- 2 - Neurospora choline kinase Cki1 PC13G12450 acetyl-CoA biosynthesis (from pyruvate) thiamine- a [protein]-N 6 - 3-isopropylmalate aminotransferase reductase Lys7- γ synthase Thr4 - PC14G00090 hypothetical 3- cerevisiae: PC22G18320 2-methylcitrate a cis-delta13-3- neutral amino cerevisiae: amino-acid harzianum: PC20G11690 adenylylsulfate [+ 3 isozymes] 5'-phosphate -synthase: crassa: -Saccharomyces D-xylulose- D-erythrose- degradation phosphate carrier-protein] monoubiquitinyl-L-lysine dehydratase val arg8 - bicarbonate Penicillium argininosuccinate synthase Saccharomyces oxoacyl-(acyl- 4α-carboxy- 24-methylenesterol D-sedoheptulose D-glyceraldehyde- cycle I oxo-C32:1-[acp] acid permease PC20G04020 aminotransferase kinase AAA81521- propanoyl-CoA anthranilate PC16G12440 PC22G25750 isopentenyl cerevisiae: PC16G14630 5-phosphate 4-phosphate a [pyruvate dehydrogenase synthase leu1 - Rhizopus Kluyveromyces imidazole acetol- chrysogenum: Arg1 - Saccharomyces cerevisiae: a hexanoyl-[acp] carrier-protein) 4β-methyl-5α- C-methyltransferase: 7-phosphate 3-phosphate glutaryl-CoA - Neurospora Penicillium O-acetyl-L-serine diphosphate phosphoryl-choline 6 a proteinogenic a proteinogenic niveus: Bat2 - lactis: PC20G14810 arginine-specific phosphate Lys7 cerevisiae: PC12G11190 synthase [+ 3 isozymes] PC20G04020 hydrogen sulfide synthase cholesta-8,24- PC21G10300 propionate E2 protein] N -lipoyl-L-lysine alpha subunit E1 thr chrysogenum: transketolase transketolase α amino acid crassa amino acid Saccharomyces carbamoyl- multifunctional isopentenyl- β episterol transaldolase 40 kD subunit of the pyruvate N-acetyl-β-D-glucosaminyl- UDP- -N-acetyl- a tRNA precursor a [procollagen]- (S)-3- a (1->4)- a cis,cis- a cis,cis- a trans-delta2- a trans-delta2- a (2E,5Z)- PC20G01920 histidinol-phosphate saccharopine PC13G08270 hypothetical 3- T32M21.120 dien-3 -ol choline-phosphate like protein like protein precursor of glcNAc-1,6-anhMurNAc 2-oxoglutarate an L-arginyl- ATP H O a glycogen ADP ATP an acyl-[acyl- [putative cerevisiae: N-acetyl-L- L-arginino-succinate protein trpC- thr diphosphate Delta- of NADH- acetyl-CoA dehydrogenase α D-glucosamine with a 5' a protein 2 hydroxybutanoyl- α-D-glucan delta7,25-3- a phosphoprotein delta15,27-3- cis,cis-delta9,27- cis,cis-delta19,37- tetracosa-2,5- phosphate transaminase his3p - reductase cys cysteine synthase oxoacyl-(acyl- -Arabidopsis cytidylyltransferase talB - Secondary Metabolite Degradation dihydrolipoamide (1->2)- -D-mannosyl- L-proline [tRNA Arg ] 2'-deoxyadenosine- carrier protein] inosine-5'- sequencing threonine 3-isopropylmalate PC22G16780 ornithine phosphoadenosine- Penicillium 24-ethylidenelophenol An02g06430 An02g06430 glutaconyl-CoA synthetase: complex Pda1 - α extension and a CoA oxo-C44:2-[acp] synthase Schizosaccharomyces thaliana: isomerase Idi1 - Pct1 - Saccharomyces Synechocystis ubiquinone Aromatic Compound Degradation dehydrogenase (1->3)- -D-mannosyl-R a tRNA precursor 3-hydroxybutyryl- NADPH- hypothetical oxo-C46:2-[acp]NADPH- 5'-diphosphate C46:3-[acp]enoyl C56:3-[acp]enoyl dienoyl-[acp]enoyl enoyl phosphate error] deaminase dehydratase LYS3 - 5'-phosphosulfate argininosuccinate 2-oxobutanoate chrysogenum: BAC82550-Penicillium carrier-protein) - Aspergillus - Aspergillus PC13G05130 Saccharomyces short 3' extension [+ 4 isozymes] acetylornithine subunit Cpa2 - pombe: PC16G12660 PC12G06970 Saccharomyces cerevisiae: PC16G02430 sp: PC22G14150 reductase NUO- Lpd1 - glycogen CoA glycogen dependent dual specificity dependent nucleoside- reductase of reductase of reductase of reductase of 5-nucleotidase general amino ILV - Arxula leu1 - Rhizopus Magnaporthe lyase ASAL - Candida trpC citrulline biosynthesis chrysogenum: synthase 3-keto-4- niger: niger: ribitol degradation cerevisiae: beta-N- prolyl-4- nucleoside ATP deacetylase Saccharomyces acetolactate synthase glutamine cerevisiae: transaldolase 40 - Neurospora xylitol degradation nopaline mannitol betanidin degradation phenylacetate [+ 3 isozymes] Saccharomyces hypothetical protein arginyl-tRNA- phosphorylase dehydrogenase phosphorylase beta-ketoacyl protein beta-ketoacyl diphosphate the lovastatin the lovastatin the lovastatin the lovastatin 5NTD_DISOM acid permease adeninivorans: niveus: L-histidinol- grisea [putative 3-phosphoadenosine- albicans: PC20G06010 PC21G14890 T32M21.120 methylzymosterol 5-dehydro episterol PC18G00660 PC18G00660 resorcinol degradation PC22G11710 acetylhexosaminidase hydroxylase- diphosphatase adenylyltransferase a proteinogenic a proteinogenic ile argE - cerevisiae: precursor ALS - indole-3-glycerol- biosynthesis I a 3-oxooctanoyl-[acp] PC21G21730 CDP-choline Tal1 - crassa: an oxidized ferroprotein (Fe III) H O degradation degradation I degradation I (aerobic) 4-hydroxymandelate quinate degradation II cerevisiae: contig_1_94_scaffold_6.tfa_290wg ribonuclease protein Gph1 - like protein Gph1 - reductase RhlG phosphatase reductase RhlG kinase NDK-1 biosynthesis biosynthesis biosynthesis biosynthesis - Discopyge Gap1 - PC23G00640 PC15G00510 phosphate sequencing [+ 2 isozymes] -Arabidopsis 2 propanoyl-CoA -Vibrio furnissii: alpha like Ynd1 - Apa2 - amino acid amino acid PC22G20150 5-phosphosulfate gln transketolase Tkl1 transketolase Tkl1 PC22G01610 D-ribitol degradation - Neurospora ommata: Saccharomyces Myxococcus error]: arg Schizosaccharomyces phosphate proline biosynthesis thaliana: dimethylallyl avenasterol Saccharomyces xylitol crotonyl-CoA PC20G04720 - Aspergillus nidulans: PC21G21470 P chain Pop1 - PC22G24800 protein transferase Ate1 Saccharomyces Saccharomyces Saccharomyces An14g00430 - Saccharomyces - Pseudomonas 3 - Aspergillus - Pseudomonas lovC - lovC - lovC - lovC - [+ 3 isozymes] histidinol- reductase ParA- -Saccharomyces -Saccharomyces Ribitol mannitol-1- betanidin phenylacetate resorcinol a [pyruvate dehydrogenase crassa: PC22G00320 cerevisiae 2-isopropylmaleate xanthus: arginine-specific PC18G01330 pombe: PC22G23110 II (from arginine) glt PC12G06970 3-oxoacyl-(acyl- diphosphate cerevisiae: [+ 25 isozymes] xylitol D-nopaline glutathione peroxidase (R)-4- L-quinate methylcitrate a [pyruvate dehydrogenase E2 Saccharomyces An02g07870 - Saccharomyces cerevisiae: cerevisiae: cerevisiae: Aspergillus niger: cerevisiae: aeruginosa: fumigatus: aeruginosa: Aspergillus Aspergillus Aspergillus Aspergillus phosphatase: L-homoserine Penicillium indoleglycerol glutaminase cerevisiae: cerevisiae: dehydrogenase phosphate phenylacetyl- mitochondrial E2 protein] N 6 -S- beta-N- PC21G15880 inosine 2-oxobutanoate PC14G01770 [+ 2 isozymes] glutamine cys carrier-protein) 4-α- PC21G16950 D-nopaline mannitol-1- hydroxymandelate quinate 5- synthase mcsA protein] N 6 -dihydrolipoyl-L-lysine N-acetyl-β-D-glucosaminyl- cerevisiae: cerevisiae: PC21G11060 PC13G11660 PC13G06830 PC13G11660 PC22G03680 PC13G11790 PC22G03680 terreus: terreus: terreus: terreus: 3-isopropylmalate carbamoyl- PC20G11690 chrysogenum: ParA phosphate A gtaA - a 3-oxooctanoyl- farnesyl- PC13G12450 PC13G12450 rbtD -Klebsiella dehydrogenase Hyr1 - Saccharomyces hypothetical acetyldihydrolipoyl-L-lysine UDP acetylhexosaminidase -Aspergillus PC20G10400 saccharopine 2-aceto-2- arg synthase Gln1 - reductase fabG - methylzymosterol 24-methylenecholesterol dehydrogenase phosphate 5- CoA ligase dehydrogenase enoyl-CoA - Aspergillus (1->2)-[N-acetyl-β-D- PC22G23570 PC12G07310 3-acetoacetyl-CoA [+ 5 isozymes] [+ 12 isozymes] dATP PC14G00090 PC14G00090 PC14G00090 PC14G00090 amino acid dehydratase acetylornithine phosphate serine O- aldolase: Aspergillus [acp] pyrophosphate a phosphatidylcholine aerogenes: xdh - cerevisiae: PC18G01780 protein RTS- hex-Penicillium niger: a cis,cis-delta7,25- a cis,cis-[+ 5 isozymes] a trans-2- acetolactate synthase superpathway of serine hydroxy- Saccharomyces Bacillus subtilis: D-erythrose- D-fructose- nos - dehydrogenase: pclA-Penicillium 1,2,4-benzenetriol qutB - Aspergillus hydratase nidulans: glucosaminyl-(1->4)]- α a (1->4)- α a cis,cis-delta9,27- a cis,cis-delta19- a (5Z)-tetracos- a proteinogenic transporter a proteinogenic leu1 - Rhizopus deacetylase synthase histidinol acetyltransferase PC21G03590 oryzae: synthase FPPS D-glyceraldehyde- PC22G04140 Galactocandida betanidin quinone beta - Homo chrysogenum: hex PC18G00410 -D-glucose maltotetraose -D-glucose 3-hydroxyC44:2- a protein delta15,27-3- enoyl-[acyl- precursor ALS - and glycine biosynthesis I sulfite butanoate cerevisiae: PC16G12960 5-dehydroavenasterol 4-phosphate 6-phosphate PC22G20800 chrysogenum: nidulans: ECHS1 PC20G13510 α + 5',5'''-diadenosine α C46:2-[acp] 37-C56:2-[acp] 5-enoyl-[acp] amino acid ATA1 - amino acid argE - subunit Cpa2 - saccharopine cysA - Aspergillus 3-oxoacyl- - Gibberella mastotermitis: Agrobacterium D-fructose- -D-mannosyl-(1->3) a tRNA precursor a [protein]- AMP phosphate H 1-phosphate -D-glucan 1-phosphate [acp] hydroxyC46:2- carrier protein] niveus: ser PC13G02130 3-phosphate D-ribulose pclA sapiens: - Rattus Arg Schizosaccharomyces Myxococcus Saccharomyces histidinol dehydrogenase ketol-acid indole PC22G03070 (acyl-carrier- [+ 5 isozymes] fujikuroi: PC21G11540 tumefaciens: 6-phosphate hydroxyquinol PC13G08380 (2S,3S)-2- -β-D-mannosyl-R with a short a tRNA tetraphosphate Homo sapiens PC20G01920 nidulans: alpha subunit of arginine degradation L-citrulline 4α-hydroxymethyl- transketolase phenylacetyl-CoA PC22G19710 norvegicus: N-acetyl-β-D- a [procollagen] L-arginine [acp] pombe: PC22G23110 3-phospho-D-glycerate xanthus: cerevisiae: dehydrogenase LYS1 - Candida reductoisomerase [+ 3 isozymes] [+ 2 isozymes] protein) PC21G15240 D-ribulokinase PC22G06570 1,2-dioxygenase 3-dehydroquinate methylcitrate 3' extension 1,6-anhydro-N succinate PC22G16570 assimilatory sulfite I (arginase pathway) a (3R)-3- 5α-cholesta- like protein [+ 4 isozymes] PC22G21270 glucosamine trans 4-hyroxy- [+ 2 isozymes] 3-isopropylmalate phosphoglycerate PC13G03320 PC06G02240 his-3 - albicans: ilv-2 - Neurospora gln reductase 24-methyldesmosterol NADH rbtK -Klebsiella arg BAA82713.1 - (S)-4- [+ 2 isozymes] itaconate -acetylmuramate homoserine O- reductase Met10 tryptophan ornithine glt hydroxyoctanoyl-[acp] [+ 2 isozymes] 8,24-dien-3β-ol sphingolipid metabolism An02g06430 D-xylulose 3-dehydroquinate (R)-3- 2-methylcitrate branched-chain L-proline general amino 2-aceto-2- dehydratase dehydrogenase like protein Neurospora PC18G01240 crassa: fabG - Bacillus pneumoniae: Arthrobacter sp: hydroxymandelate degradation acetyltransferase - Saccharomyces arg synthase Trp5 - carbamoyltransferase 3-hydroxyacyl- geranyl isofucosterol - Aspergillus dehydratase: hydroxybutanoyl- dehydratase alpha-keto acid acid permease hydroxy- leu1 - Rhizopus An17g02330 - Aspergillus L-ornithine carbamoyl- crassa: PC13G15810 subtilis: PC16G10220 D-xylulokinase PC16G12860 a proteinogenic a proteinogenic Saccharomyces argB - Aspergillus niger pro niger: PC16G12160 PrpD - dihydrolipoyl α Gap1 - butanoate niveus: niger: PC20G00530 phosphate PC16G14140 lys metE - Aspergillus cerevisiae: arginase argA 2,3-dihydroxy- glutamate 5- glutamate PC16G12960 [acp] dehydrase: diphosphate Xks1 - ring 1,2-epoxy- [+ 3 isozymes] CoA itaconate all-trans- an N-acetyl-D- UDP- -N-acetyl- 1-chloro-2,4- a cis,cis- a cis,cis- a (7Z)-3- a cis,cis- a [protein]-L- a trans-delta2- a trans-delta2- (R)-3- a trans-delta2- amino acid amino acid nidulans: PC12G08580 -Aspergillus cerevisiae: [putative sequencing kinase Pro1 - biosynthesis IV PC14G00080 α ser PC18G00660 fumarate D-ribulokinase Salmonella acyltransferase a proteinogenic a 5-L-glutamyl- O-acetyl-L- methanethiol a c-type 5-hydroxyferulate coenzyme A chitin glutathione a carboxylic ester Saccharomyces ketol-acid PC15G00510 3-phosphoglycerate 3-methylvalerate farnesyl 4 -formyl- Saccharomyces phenylacetyl-CoA 3-hydroxy- 3-dehydroshikimate 3-hydroxyacyl- succinate-CoA geranyl-geranyl hexosaminide D-glucosamine dinitrobenzene delta5,17-3- delta9,27-3- oxohexacos- delta21,39-3- methionine cis,cis-delta5,23- cis,cis-delta15,33- hydroxybutanoyl- cis-delta19- GMP histidinal PC21G18210 niger: PC22G13470 error]: PC22G18390 proline Saccharomyces [+ 5 isozymes] α transketolase Tkl1 rbtK -Klebsiella urate degradation typhimurium: - Gallus gallus: amino acid [peptide] homoserine cytochrome cerevisiae reductoisomerase (2R,3S)-3- dehydrogenase like protein ornithine a (3R)-3- diphosphate 5 -cholesta- campesterol 24-epi-campesterol cerevisiae: cis,cis-muconate CoA ligase beta diphosphategeranylgeranyl oxo-C36:2-[acp]NADPH- oxo-C46:2-[acp]NADPH- 7-enoyl-[acp]NADPH- oxo-C58:2-[acp] peptide C42:3-[acp] C52:3-[acp] CoA C38:2-[acp] hydrogen sulfide dihydroxy-acid a (2E)-oct-2-enoyl-[acp] β serine -Saccharomyces pneumoniae: p-hydroxybenzoylformate to allantoin PC20G13350 PC22G05180 NADPH- enoyl enoyl mitochondrial enoyl 5-nucleotidase ilv-2 - Neurospora PC13G09710 dehydrogenase cerevisiae: 8,24-dien-3 -ol ∆ 24-25 PC12G05750 sorbitol dehydrogenase chain beta-SCS methionine isopropylmalate An12g01580 - Aspergillus carbamoyltransferase dehydratase Ilv3 tryptophan L-ornithine gln hydroxyoctanoyl- synthase: -sitosterol palmitoyltransferase 2 transferase type beta-N- chitin synthase dependent dependent dependent dependent reductase of reductase of enoyl-CoA reductase of crassa: histidinol O-acetyl-L-homoserine L-ornithine slgA -Drosophila PC13G05350 cerevisiae: PC13G05740 degradation I hmgA - Sulfolobus cis-2- - Trichomonas dihydrolipoamide 4-coumarate- glutathione S- lipase LipP - sulfoxide 5NTD_DISOM amino acid niger: PC12G02680 argB - Aspergillus niger - Saccharomyces synthase Trp5 - NADH-dependent [acp] PC20G10860 Lcb2 - Saccharomyces D-xylulose- urate gamma- O-acetylhomoserine II beta-subunit acetylhexosaminidase holocytochrome- III like Chs7 - beta-ketoacyl beta-ketoacyl beta-ketoacyl beta-ketoacyl the lovastatin the lovastatin hydratase the lovastatin PC13G15810 beta- dehydrogenase melanogaster: fatty-acyl-CoA synthase PC13G12450 D-ribulose- solfataricus: methylaconitate vaginalis: acetyltransferase CoA ligase 4CL transferase Pseudomonas reductase Mxr1 - - Discopyge system N 3-phospho-hydroxypyruvate [putative sequencing selenocysteine biosynthesis cerevisiae Saccharomyces ornithine L-glutamate- glutamate synthase 3-hydroxyacyl- farnesyl cerevisiae: 5-phosphate oxepin-CoA urate Glutamyltranspeptidase (thiol)-lyase cysD - RABGGTB - -Vibrio furnissii: c synthase Cyt2 - Saccharomyces reductase RhlG reductase RhlG reductase RhlG reductase RhlG biosynthesis biosynthesis ECHS1 biosynthesis isopropylmalate his-3 - ornithine PC21G19930 beta chain fas1p - α D-glyceraldehyde- 5-phosphate D-sorbitol PC19G00460 aconitase B: PC20G10080 Lat1 - - Arabidopsis omega - sp: PC21G09740 Saccharomyces aommata: proteinogenic transporter a proteinogenic 2,3-dihydroxy- error]: PC22G18390 II (archaea and eukaryotes) [putative cerevisiae: transaminase 5-phosphate NADH-GOGAT like [acp] diphosphate 4 -carboxy- PC13G10800 2-maleylacetate oxidase uaz protocatechuate - Pseudomonas Aspergillus nidulans: Homo sapiens: PC22G24800 Saccharomyces cerevisiae: - Pseudomonas - Pseudomonas - Pseudomonas - Pseudomonas lovC - lovC - - Rattus lovC - dehydrogenase phosphoserine Neurospora O-acetylhomoserine transaminase [+ 2 isozymes] Schizosaccharomyces α crinosterol brassicasterol 3-phosphate sorbitol PC13G03110 Saccharomyces thaliana: Sus scrofa: [+ 5 isozymes] cerevisiae: PC22G00320 amino acid like protein amino acid 3-methylvalerate sequencing error]: PC21G03590 otaA - protein An07g09920 dehydrase: synthase: 5 -cholesta- ribulose-5- 4-hydroxybenzaldehyde -Aspergillus [+ 2 isozymes] [+ 2 isozymes] aeruginosa: PC22G03740 PC23G00630 PC21G08870 cerevisiae: PC12G15180 aeruginosa: aeruginosa: aeruginosa: aeruginosa: Aspergillus Aspergillus norvegicus: Aspergillus A leu2A - transaminase Ser1 crassa: (thiol)-lyase cysD - otaA - pombe: PC14G00740 β succinate dehydrogenase cerevisiae: beta-N- PC22G24780 PC22G04890 guanosine An04g02150 - (S)-1-pyrroline- - Aspergillus niger: PC14G00080 PC21G15240 8,24-dien-3 -ol sitosterol 3-dehydrosphinganine phosphate- maleylacetate aconitase B: itaconyl-CoA [+ 3 isozymes] [+ 2 isozymes] PC22G18310 PC22G03680 PC22G03680 PC22G03680 PC22G03680 PC18G04330 terreus: terreus: PC22G21270 terreus: dihydroxy-acid Aspergillus niger: - Saccharomyces PC16G14140 ser Aspergillus nidulans: Aspergillus PC18G02530 Aspergillus glutamate-5- fatty-acyl-CoA synthase dehydrogenase SDH - Rattus flavus: acetoacetyl-CoA PC20G01630 geranylgeranyl diphosphate acetylhexosaminidase [+ 2 isozymes] [+ 8 isozymes] [+ 10 isozymes] a protein-L- Aspergillus niger L-citrulline 5-carboxylate PC22G11310 epimerase Rpe1 3-oxo-5,6- reductase PC20G13350 PC14G00090 PC14G00090 PC14G00090 dehydratase Ilv3 PC16G13350 cerevisiae: PC12G04370 PC23G00630 nidulans: trp nidulans: semialdehyde a (2E)-oct- beta chain fas1p - (2E,6E)-farnesyl cytochrome b a reduced ferroprotein (Fe II) O norvegicus: PC22G20960 geranylgeranyltransferase I hex-Penicillium an alcohol a carboxylate [+ 5 isozymes] a cis,cis-delta9,27-[+ 5 isozymes] a (3R,7Z)-3-[+ 5 isozymes] a cis,cis-[+ 5 isozymes] methionine- a cis,cis- crotonyl-CoA dihydroxy-acid glt 3-ketodihydrosphingosine 2 - Saccharomyces dehydrosuberyl- MacA - (2R,3S)-2- α γ a cis,cis-delta5,17-3- a cis,cis-delta5,23- a cis-delta19- - Saccharomyces his cytosolic serine-- PC18G03600 PC18G03600 dehydrogenase: 2-enoyl-[acp] diphosphate TCA cycle TCA cycle variation III (eukaryotic) PC21G23190 5-hydroxyisourate precursor of an -( -L- beta chain GGTase-I - Rattus chrysogenum: hex an apo-[c-type 3-hydroxyC46:2- hydroxyhexacos- delta21,39-3- S-oxide delta15,33- dicarboxylic (2S)-2-isopropyl- argininosuccinate [+ 2 isozymes] dehydratase Schizosaccharomyces reductase: PC13G08860 subunit Sdh3 - cerevisiae: CoA Rhodococcus methylisocitrate Peptide acetate protoheme IX chitin UDP 2,4-dinitrophenyl- hydroxyC36:2[acp] C42:2-[acp] C38:1-[acp] cerevisiae 3-phospho-L-serine asparagine tRNA ligase Ses1 γ PC13G05350 5α-cholesta- [+ 4 isozymes] salicylate degradation I acetyl-CoA C- glutamyl)-L- met norvegicus: PC14G01660 cytochrome] 5-hydroxy-feruloyl-CoA [acp] 7-enoyl-[acp] hydroxyC58:2- C52:2-[acp] amino acid 3-oxosuccinate synthase Arg1 - L-glutamate γ- like protein L-glutamate - enoyl-[acyl- pombe: PC21G10870 dehydrosqualene Saccharomyces PC12G00550 opacus: 4-hydroxybenzoate S-glutathione a proteinogenic a proteinogenic [putative biosynthesis I - Saccharomyces 8,24-dien-3-one stigmasterol D-fructose acetyltransferase - L-citramalyl-CoA amino acid prephytoene with reduced L- [acp] permease Dip5 - Saccharomyces semialdehyde An15g06700 semialdehyde carrier-protein] synthase: a sphinganine oxaloacetate cerevisiae: D-xylulose- PC18G05540 methylisocitrate an N-acetyl- amino acid amino acid sequencing error]: phosphoserine cerevisiae: L-glutamate γ- an octanoyl-[acp] Rattus norvegicus: acetate conversion diphosphate Rh cysteine residues Saccharomyces cerevisiae: - Aspergillus reductase: PC21G13930 PC22G14260 5-phosphate phenol salicylate lyase: D-hexosamine PC18G02530 phosphatase Ser2 PC20G00490 semialdehyde 2,3-dehydroadipyl- maleylacetate 5-hydroxy-2- PC22G00420 to acetyl-CoA cerevisiae asp PC12G11190 L-homocysteine niger: PC14G00080 presqualene [+ 2 isozymes] degradation salicylate hydroxylase PC22G23150 4-methyl-2- - Saccharomyces asparagine phenylalanine biosynthesis I mitochondrial β-alanine biosynthesis V hypothetical 3- CoA reductase oxo-4-ureido- dihydroxy-acid PC13G02430 enoyl diphosphate I (aerobic) nahG - Pseudomonas cytosolic α oxopentanoate cerevisiae: PC20G03210 L-arginino- arg glycine biosynthesis IV glutamate MacA - protocatechuate 2,5-dihydro- acetate UDP- -N-acetyl- (N-acetyl-β-D-glucosaminyl- 2,5-diamino-6- a 3- a cis,cis- a (5Z)-3- a cis,cis- a trans-delta2- a trans-delta2- 3-carboxy- a trans-delta2- general amino dehydratase synthase Asn1 - serine--tRNA (S)-1-pyrroline- 2-keto-3- (S)-1-pyrroline- ornithine reductase of oxoacyl-(acyl- zymosterol putida: PC22G17670 acetyl-CoA C- (R)-lactate an oxidized c- thiosulfate UDP-D-glucose a pectate (S)-nicotine AMP succinate cystathionine biosynthesis III squalene Rhodococcus 1H imidazole- phenol pyruvate succinate pyruvate acetate--CoA ligase D-glucosamine 1,2)-α-D-mannosyl-1,3-(β- a hexanoyl-[acp] a malonyl-[acp] O-acetyl-L-serine a sterol a stearoyl-[acp] (5-phospho-D- oxodocosanoyl- delta7,19-3- oxotetracos- delta13,31-3- cis-delta21- cis,cis-delta11,23- 2,5-dihydro- cis-delta13- acid permease like protein branched-chain- Saccharomyces chorismate ligase serS cystathionine 5-carboxylate methyl-valerate spermine 5-carboxylate transaminase the lovastatin carrier-protein) sphinganine 4-hydroxysphinganine glyoxysomal citrate [+ 12 isozymes] acetyltransferase type cytochrome GMP a proteinogenic a proteinogenic ser argininosuccinate β-synthase: synthase: opacus: 5-carboxylate phenol 2- facA-Penicillium N-acetyl-D-glucosaminyl- ribosylamino) [acp] oxo-C38:2-[acp] 5-enoyl-[acp] oxo-C50:2-[acp] phenylacetate C40:2-[acp] C42:3-[acp] 5-oxofuran- C32:2-[acp] 5-nucleotidase Gap1- An15g06700 amino-acid cerevisiae: chorismate mutase - Zea mays: beta-lyase metG - spermine oxidase: pyrroline-5- arginase argA otaA - thr biosynthesis synthase 1-phosphate synthase - Cucurbita catechol Erg10 - fatty-acyl-CoA synthase NADPH- NADPH- NADPH- NADPH- mitochondrial enoyl enoyl amino acid amino acid lyase ASAL - PC13G05320 delta-1-pyrroline- branched-chain- 2-oxoglutarate PC21G13930 3-hydroxyadipyl- PC16G14780 monooxygenase chrysogenum: facA hypothetical protein 1,2-α-D-mannosyl- guanylate kinase pyrimidin-4(3H)-oneriboflavin hydroxylase 2-acetate 5NTD_DISOM Penicillium - Aspergillus aminotransferase PC22G17940 aroC -Aspergillus PC13G09170 Aspergillus nidulans: PC12G08750 carboxylate -Aspergillus Aspergillus metal-activated pyridoxal lovC - T32M21.120 mitochondrial malate sp: PC12G00660 Saccharomyces beta chain fas1p - pectate dependent dependent dependent dependent enoyl-CoA reductase of carboxy-cis,cis- reductase of cytoplasmic serine Candida albicans: 5-carboxylate amino-acid glutamate alkaline UQ CoA -Trichosporon contig_1_94_scaffold_6.tfa_290wg 1,6)-β-D-mannosyl-R protein D-lactate cysteine sterol 3-beta- Guk1 -Saccharomyces biosynthesis pahA - - Discopyge chrysogenum niger: Bat2 - asparagine nidulans: PC21G08250 an L-seryl- PC13G06020 reductase niger: nidulans: enzyme D-threonine Aspergillus -Arabidopsis squalene 5α-cholesta- dehydrogenase MDH - Mus cerevisiae: acetyl coenzyme A hypothetical 3-oxoacyl- Schizosaccharomyces lyase plyA - beta-ketoacyl beta-ketoacyl beta-ketoacyl beta-ketoacyl hydratase the lovastatin muconate the lovastatin hydroxymethyltransferase PC20G06010 dehydrogenase aminotransferase 3-aminopropanal dehydrogenase ceramidase Ypc1 3-oxoadipate beigelii: - Aspergillus nidulans: PC21G21470 dehydrogenase synthase glucosyltransferase cerevisiae: PC16G01840 protein Rib7 - Penicillium ommata: PC13G02430 Saccharomyces prephenate sec P5CR - PC18G03600 thaliana: 7,24-dien-3β-ol musculus: PC21G22090 PC22G10140 synthase - Tetrahymena (acyl-carrier-protein) pombe: PC14G00740 Aspergillus reductase RhlG reductase RhlG reductase RhlG reductase RhlG ECHS1 biosynthesis cyclase CMLE biosynthesis Shm2 - Saccharomyces synthase asnB - hydrogen selenide [tRNA ] p5cdh - Homo Bat2 - PC13G09710 aldolase - Arthrobacter gdhA-Penicillium terreus: succinate S-allantoin PC21G02970 YEL071w - BAC82550- involved in Saccharomyces chrysogenum: PC22G00320 cerevisiae: aldehyde Zalerion PC12G06970 squalene -Saccharomyces (S)-malate [+ 3 isozymes] citrate pyriformis: PC13G05130 synthase T32M21.120 fatty-acyl-CoA synthase guanylate kinase Guk1 - niger: - Pseudomonas - Pseudomonas - Pseudomonas - Pseudomonas - Rattus lovC - - Neurospora lovC - hypothetical 2-keto-3- cerevisiae: PC13G05010 Bacillus subtilis: arg sapiens: Saccharomyces sp: PC20G14030 chrysogenum: PC14G00090 phosphoryl- phytosphingosine-1-P mitochondrial aconitate [+ 3 isozymes] Saccharomyces Penicillium autophagocytosis cerevisiae: PC22G02230 PC22G16780 hypothetical chorismate L-cystathionine dehydrogenase arboricola: monooxygenase - palmitaldehyde cerevisiae: acetyl-CoA acetyl-CoA N-acetyl-β-D-glucosaminyl- UDP -Arabidopsis thaliana: beta chain fas1p - Saccharomyces cerevisiae PC22G24890 aeruginosa: aeruginosa: aeruginosa: aeruginosa: norvegicus: Aspergillus crassa: Aspergillus neutral amino methyl-valerate cytoplasmic serine PC21G12620 PC12G08900 cerevisiae: threonine aldolase gdhA ethanolamine hydratase Aco1 - 3-oxoadipyl-CoA catechol cerevisiae: chrysogenum: Atg26 - Pichia 5-amino-6-(5'-PC12G01420 adenosinea proteinogenic a proteinogenic [+ 4 isozymes] mutase/prephenate aldA - Aspergillus PC22G23710 L-ornithine a 3-oxodecanoyl-[acp] Rattus norvegicus: PC21G15720 1,4-(N-acetyl-D-glucosaminyl- PC12G06970 Schizosaccharomyces [putative sequencing PC22G03680 PC22G03680 PC22G03680 PC22G03680 [+ 9 isozymes] PC22G21270 terreus: PC20G02010 terreus: acid permease branched-chain- hydroxymethyltransferase asn [+ 2 isozymes] PC22G16780 Gly1 - Saccharomyces an octanoyl-[acp] Saccharomyces PC21G14970 PC21G14890 pastoris; Gene-ID: phosphoribosylamino) 3-carboxy-cis amino acid amino acid dehydratase pheA - Aquifex holocytochrome- niger: PC21G22810 glt PC22G15550 fumarate hydratase 1,2)-α-D-mannosyl-1,3-(β- pombe: PC21G10870 error]: PC12G01160 an unsaturated [+ 5 isozymes] [+ 5 isozymes] [+ 5 isozymes] 2'-hydroxynicotine a cis,cis-delta3,21- PC14G00090 PC14G00090 - Neurospora amino-acid Shm2 - Saccharomyces an O-phospho-L- [+ 2 isozymes] cerevisiae: PC12G01020 lathosterol cerevisiae: PC22G02000 Atg26: PC12G16190 a pectate uracil a (3R)-3- a cis,cis-delta7,19- a (3R,5Z)-3- a cis,cis-[+ 5 isozymes] a cis,cis- ,cis-muconate leu aeolicus: PC20G00720 selenophosphate cystathionine c synthase cyt-2 - [+ 4 isozymes] ornithine 3-oxoacyl-(acyl- (S)-2,3- fumR - Rhizopus N-acetyl-D-glucosaminyl- [+ 2 isozymes] a (2E)-octadec- GDP pectate C40:2-[acp] a cis-delta13- crassa aminotransferase seryl-[tRNA Sec ] glt [+ 7 isozymes] gly hypothetical 3- a phytoceramide hydroxydocosanoyl- 3-hydroxyC38:2- hydroxytetracos- delta13,31- delta11,23- cerevisiae: PC12G16020 γ carbamoyltransferase carrier-protein) oryzae: PC22G23810 mitochondrial aconitase 1,2-α-D-mannosyl- a reduced c- 2-enoyl-[acp] C32:1-[acp] Bat2 - phenylpyruvate -synthase: Neurospora crassa: pro oxoacyl-(acyl- epoxysqualene a 3-oxooctanoyl-[acp] pyruvate oligosaccharide [acp] [acp] 5-enoyl-[acp] 3-hydroxy C42:2-[acp] ile β reductase fabG - very long chain fatty hydroxylase Aco1 1,6)-β-D-mannosyl-R a sterol 3- UDP PC16G12440 PC22G25750 -alanine argB - Aspergillus niger carrier-protein) lanosterol hypothetical protein succinyl-CoA type cytochrome acetate C50:2-[acp] glycoprotein- Saccharomyces gly Bacillus subtilis: acid biosynthesis - Saccharomyces glyoxylate cycle S-sulfo-L-cysteine glucoside aromatic aminotransferase [+ 3 isozymes] [putative sequencing synthase synthase erg7p - SPAC30C2.08 - associated cerevisiae: PC16G12960 7-dehydro- cerevisiae: PC13G03110 I Aro8 - Saccharomyces error]: PC22G18390 T32M21.120 Schizosaccharomyces a long-chain Schizosaccharomyces a proteinogenic amino acid a proteinogenic PC22G16780 an L- [+ 5 isozymes] cholesterol a (2'R)-2'-hydroxy- Carbohydrate Degradation cerevisiae: PC12G11860 cys -Arabidopsis pombe: PC22G14100 acyl-CoA pombe: PC13G03060 glyoxylate amino acid transporter amino acid [+ 4 isozymes] selenocysteinyl- L-citrulline phytoceramide fumarate cis-aconitate thaliana: a (3R)-3- mitochondrial aconitate (25R)-3α,7α-dihydroxy- a 2'- a 2-[(3S)-3-amino- 5-amino-6-(5-phospho- a 3- a cis,cis- a cis,cis- a trans-delta2- a trans-delta2- a (1->4)- 6-O-mycolyl- b0,+AT1 - sec lanosterol a pyrimidine base lesion in DNA an acyl-[acyl- oxalate glycogen cotinine urea phe [tRNA ] mannitol methylmalonate semialdehyde 5β-cholestanoyl-CoA deoxyribonucleoside lotaustralin 3-carboxypropyl]-L- oxodocosanoyl- delta5,23-3- delta11,23-3- cis-delta15- cis,cis-delta11,29- α-D-glucan trehalose-6- Mus musculus ile PC12G06970 hydroxydecanoyl-[acp] synthase erg7p - hydratase Aco1 - trehalose degradation V D-arabinose glucose and glucose-1-phosphate degradation D-mannose melibiose degradation [DNA] carrier protein] D-ribosylamino)uracil succinate dehydrogenase degradation II apurinic endonuclease hypothetical protein 5'-triphosphate fatty-acyl-CoA synthase histidine-[translation oxalate decarboxylase riboflavin [acp] oxo-C42:2-[acp] oxo-C42:2-[acp] phenylacetate C34:2-[acp] C48:3-[acp] extracellular phosphate cyanamide 3-hydroxyacyl- Schizosaccharomyces cholesterol Saccharomyces degradation II trehalose degradation NADPH- NADPH- NADPH- mitochondrial enoyl trehalose-6- hypothetical a 3-oxodecanoyl- a long-chain a 2,3,4-saturated (4R)-4-hydroxy-N-[(2R)-2- cytochrome b subunit α lactose degradation III Apn1 - Saccharomyces CAD16864.1 - Ralstonia beta chain fas1p - elongation factordiphthamide 2] like protein An03g01140 biosynthesis hydroxylase alpha-amylase hydratase - [acp] dehydrase: pombe [putative cerevisiae: PC22G02000 D-mannitol trehalose -D-glucose degradation melibiose methylmalonate- beta-glucosidase dependent dependent glucoamylase dependent enoyl-CoA reductase of phosphate neutral amino [acp] acyl-CoA 3-oxoacyl-CoA hydroxy-very-long-chain-acyl]- Sdh3 - Saccharomyces D-arabinose D-mannose cerevisiae [putative solanacearum: Schizosaccharomyces methyltransferase - Aspergillus niger: protein Rib7 - pahA - amyA/amyB Myrotheciuma proteinogenic a proteinogenic PC14G00080 sequencing error]: mitochondrial aconitase malate synthase mannitol 1-phosphate II (trehalase) semialdehyde DNA polymerase precursor beta-ketoacyl beta-ketoacyl III Wsc2 - beta-ketoacyl hydratase the lovastatin phosphatase acid permease 1-O-[(1D-myo-inositol-1-O-yl) cerevisiae: PC22G14260 6-phosphate sequencing error]: PC21G07860 pombe: PC21G10870 Dph5 - PC12G00920 Saccharomyces Penicillium - Aspergillus verrucaria: amino acid amino acid Aminoacyl-tRNA Charging tRNA charging pathway 3-oxoacyl- PC06G01230 hydroxylase Aco1 acuE -Aspergillus dehydrogenase: trehalose mannose-6- lactose dehydrogenase V Pol5 - BGLUC - reductase RhlG reductase RhlG Saccharomyces reductase RhlG ECHS1 biosynthesis like protein - Neurospora hydroxyphosphoryl]sphinganine [+ 2 isozymes] trehalose alpha-galactosidase PC22G09800 hypothetical protein Saccharomyces oxalate decarboxylase cerevisiae: chrysogenum: niger: PC22G05020 (acyl-carrier- a (2E)-dec-2-enoyl-[acp] - Saccharomyces isocitrate lyase nidulans: PC20G13550 PC22G09390 phosphoglucomutase: Trehalase: phosphate MMSDH - Rattus Saccharomyces Kluyveromyces fatty-acyl-CoA synthase - Pseudomonas - Pseudomonas cerevisiae: - Pseudomonas - Rattus lovC - An11g10990 crassa phosphorylase: 1 agl1 - Penicillium CAD16864.1 - cerevisiae: like protein An15g03980 PC13G05670 PC22G02230 PC22G12340 [+ 2 isozymes] protein) lanosterol cholesterol biosynthesis a 2,3,4- cerevisiae: PC13G03110 acuD -Aspergillus D-ribulose PC18G01390 PC22G03670 isomerase norvegicus: PC22G02810 apurinic/apyrimidinic cerevisiae marxianus: beta chain fas1p - a 2-[(3S)-3-carboxy-3- 5-amino-6-(5'- aeruginosa: aeruginosa: PC20G02620 aeruginosa: norvegicus: Aspergillus - Aspergillus met a tRNA Met lys a tRNA Lys pro a tRNA Pro ile a tRNA Ile a (2E)-2- [+ 12 isozymes] PC18G00270 simplicissimum: beta-galactosidase PC16G12550 [+ 6 isozymes] reductase fatty-acyl-CoA synthase II (via 24,25- saturated (3R)-3- nidulans: PC22G03660 phosphoglucomutase: manA - (AP) endonuclease Ralstonia solanacearum [truncated ORF]: Schizosaccharomyces (methylammonio)propyl]- - Aspergillus niger: phosphoribosylamino) PC22G03680 PC22G03680 [+ 8 isozymes] PC22G03680 [+ 9 isozymes] PC22G21270 terreus: niger: cyanamide ser α enoyl-CoA D-mannose D-ribulokinase D-glucose alpha,alpha- lacA - Aspergillus [+ 2 isozymes] PC22G19810 hypothetical ser a tRNA fabG - Bacillus beta chain fas1p - lanosterol 14 - hydroxyacyl-CoA a mannosylinositol succinate NAD(+)-isocitrate D-threo-isocitrate D-threo-isocitrate (S)-malate PC21G14820 Apn2 - Saccharomyces [putative sequencing PC22G09870 PC12G01820 5'-hydroxycotinine a cis,cis-delta3,15- PC14G00090 maltopentaose dihydrolanosterol) α-D-glucose rbtK -Klebsiella PC20G04410 trehalase treA Candida sucrose degradation I niger: PC14G01510 [+ 12 isozymes] a trans-2- pombe: PC14G00740 L-histidine-[translation uracil a (3R)-3-[+ 5 isozymes] a cis,cis-delta5,23-[+ 5 isozymes] a cis,cis-[+ 5 isozymes] a cis,cis- PC20G08480 neutral amino leu a tRNA Leu subtilis: Schizosaccharomyces demethylase: phospho-(2'R)-2'- dehydrogenase subunit mannokinase: α-D-glucose alpha-galactosidase cerevisiae: PC20G07790 error]: PC13G07100 formate C34:2-[acp] trehalose- a proteinogenic a proteinogenic (2E,6E)-farnesyl - Aspergillus albicans: α α [+ 11 isozymes] enoyl-[acyl- elongation factor 2] hydroxydocosanoyl- 3-hydroxyC42:2- delta11,23-3- delta11,29- cytosolic methionine- cytosolic lysine--tRNA Phe multifunctional glutamine- mitochondrial isoleucine- asp PC12G10870 mitochondrial aconitate 1-phosphate pneumoniae: α secreted beta- (25S)-3 ,7 -dihydroxy- β mono-mycolate acid permease phe a tRNA tRNA asp PC16G12960 pombe: PC14G00740 hydroxyphytoceramide I idh1 - Ajellomyces PC20G13040 -D-glucose aglC - Aspergillus + an apyrimidinic site in DNA glycogen -D-glucose amino acid amino acid 4,4-dimethyl-5-α- diphosphate mitochondrial succinat-CoA ligase hydratase Aco1 - UDP-glucose 4- PC16G10220 nidulans: PC13G08170 sucrose-6- bicarbonate NADH propanoyl-CoA H 5β-cholestanoyl-CoA carrier protein] [acp] [acp] hydroxyC42:2- C48:2-[acp] - Neurospora asn Asn tyr Tyr -tRNA ligase Mes1 ligase like protein cytosolic serine-- trp Trp glt glu proline--tRNA ligase -tRNA ligase Ism1 gln a tRNA Gln thr Thr Ala ala dehydrosqualene capsulatus: PC14G01170 [+ 2 isozymes] phosphoglucomutase: 6-phosphate niger: PC21G20400 galactosidase 2-hydroxy-2- β tRNA a tRNA a tRNA a tRNA a tRNA a tRNA [+ 5 isozymes] fatty-acyl-CoA synthase cholesta-8,14,24- enoyl-CoA Saccharomyces mitochondrial malate PC16G11870 phosphate -D-glucose [acp] crassa Arg - Saccharomyces An01g03650 - Aspergillus tRNA ligase Ses1 Gly Val Aats-glupro - Drosophila - Saccharomyces cytosolic leucine--tRNA His Cys synthase: alpha chain Lsc1 epimerase Gal10 β mannose-6- lacA - Aspergillus arg a tRNA gly a tRNA val a tRNA his a tRNA cys a tRNA a (3R)-3- precursor of isocitrate dehydrogenase D-mannose PC18G01390 D-ribulokinase -D-glucose β [DNA] methylbutyronitrile cerevisiae: PC16G02040 niger: PC16G09340 - Saccharomyces melanogaster: PC21G02050 cerevisiae: PC21G13710 ligase - Neurospora beta chain fas1p - trien-3-β-ol PC21G13930 hydratase - Saccharomyces cerevisiae: PC22G02000 - Saccharomyces -D-glucose phosphate niger: PC06G00600 cytosolic phenylalanine-- cytosolic aspartate- hydroxydecanoyl- presqualene dehydrogenase MDH - Mus musculus: 6-phosphate α-D-glucose rbtK -Klebsiella β β a proteinogenic a proteinogenic cerevisiae: PC20G00490 crassa: PC22G02510 Schizosaccharomyces ECHS1 a mannosyl- cerevisiae: PC13G13290 mitochondrial cerevisiae: isomerase Pmi40 exo-inulinase -D-galactose -D-glucose ArlP mitochondrial asparagine- mitochondrial tyrosine- mitochondrial cytosolic lysine-- tRNA ligase alpha subunit cytosolic tryptophan- mitochondrial glutamate- cytoplasmic proline-- cytoplasmic isoleucine- cytosolic glutamate-- cytosolic threonine- cytosolic alanine-- -tRNA ligase Dps1 [acp] diphosphate (NAD+) chain Idh2 PC21G22090 6-phosphate pneumoniae: glucokinase amino acid amino acid pombe: PC21G10870 - Rattus diphosphoinositol-(2'R)- aconitase hydroxylase mannose-6- PC20G08410 glucokinase β-D-glucose- - Saccharomyces inu1 - arginine--tRNA ligase -tRNA ligase YCR024c -tRNA ligase CYT- methionine--tRNA tRNA ligase Krs1 Frs1 -Saccharomyces mitochondrial serine-- glycine-tRNA ligase -tRNA ligase Wrs1 valine--tRNA ligase -tRNA ligase Mse1 tRNA ligase like protein -tRNA ligase Ils1 tRNA ligase - Arabidopsis mitochondrial leucine--tRNA histidine--tRNA ligase -tRNA ligase Ths1 tRNA ligase Ala1 cysteine--tRNA ligase - Saccharomyces 3-hydroxyacyl- - Saccharomyces [+ 3 isozymes] PC13G05740 glkA - β-D-galactose β-D-glucose D-glyceraldehyde- a [lipoyl-carrier a cis,cis- a trans-delta2- squalene norvegicus: 2'-hydroxyphytoceramide phosphate glkA - 6-phosphate Aspergillus UDP-D-glucose dimethylallyl a (3R)-3- a [protein] C-terminal 3+ Msr1 - Saccharomyces - Saccharomyces 18 - Neurospora ligase MetRS - Candida - Saccharomyces cerevisiae: PC18G02170 tRNA ligase serS - Zea Grs1 - Saccharomyces - Saccharomyces cyt-20 - Neurospora - Saccharomyces An08g02860 - Aspergillus - Saccharomyces thaliana: PC21G15760 ligase leu-5 - Neurospora Hts1 - Saccharomyces - Saccharomyces - Saccharomyces YNL247w - Saccharomyces cerevisiae: PC22G21630 [acp] Aco1 - Saccharomyces [+ 2 isozymes] Aspergillus cerevisiae: D-mannosylglycoprotein succinate ATP H O ATP H O 6 10-oxogeraniol AMP glycolate Fe a decanoyl-[acyl-carrier protein] 4,4- PC22G21270 cerevisiae: PC13G11380 D-ribulose- Aspergillus ATP a tRNA precursor 2'-hydroxygenistein 2 2 S-farnesyl-L-cysteine 3-phosphate a palmitoyl-[acp] protein]-N -[(R) a histone delta11,29-3- 2'-deoxyguanosine- cis,cis-delta19,31- synthase: cerevisiae: PC13G03110 isomerase D-glucono- PC13G12020 niger: CTP diphosphate hydroxyoctadecanoyl-[acp] cerevisiae: PC12G12720 cerevisiae: PC12G15910 crassa: PC13G07980 albicans: PC13G07310 cerevisiae: PC12G09250 [+ 2 isozymes] mays: PC13G09170 cerevisiae: PC20G01010 cerevisiae: PC20G05510 crassa: PC20G09480 cerevisiae: PC21G01750 niger: PC16G07440 cerevisiae: PC16G12120 [+ 2 isozymes] crassa: PC12G04280 cerevisiae: PC22G02880 cerevisiae: PC22G03830 cerevisiae: PC22G10240 cerevisiae: PC22G14160 [+ 3 isozymes] dehydrase: dimethylzymosterol β 5-phosphate niger: D-fructose- farnesyl cysteine aldehyde -dihydrolipoyl]- oxo-C48:2-[acp] alcohol 5'-diphosphate C50:3-[acp] AMP deaminase glycolate ferric/cupric PC21G13930 succinyl-CoA 2-oxoglutarate manA - -D-glucose 1,5-lactone niger: PC21G14720 3-oxoacyl-(acyl- hypothetical 3- histone NADPH- enoyl hypothetical PC14G00080 hypothetical 3- cis-aconitate oxaloacetate PC22G23550 6-phosphate carboxyl- dehydrogenase L-lysine precursor of dehydrogenase nucleoside- Amd1 - oxidase GOX - reductase Fre2 - Candida ribulose-5- PC22G23550 [+ 4 isozymes] succinate-CoA ligase hypothetical AAA- myosin Myo2 - carrier-protein) oxoacyl-(acyl- acetyltransferase dependent reductase of neutral amino oxoacyl-(acyl- squalene glucokinase β-D-glucose- glycoprotein farnesyl- methyltransferase aldA - dihydrolipoamide C ADHC - diphosphate Saccharomyces Mus musculus: Saccharomycesa proteinogenic a proteinogenic Arg Asn Tyr Met Lys Phe ser Gly Trp Val Glu Pro Ile Gln Leu His Thr Ala Cys asp a (2E)-dec- mitochondrial aconitate albicans: phosphate- tRNA reductase fabG - carrier-protein) Gcn5 - beta-ketoacyl the lovastatin an L-arginyl-[tRNA ] an L-asparaginyl-[tRNA ] an L-tyrosyl-[tRNA ] an L-methionyl-[elongator tRNA ] an L-lysyl-[tRNA ] an L-phenylalanyl-[tRNA ] an L-seryl-[tRNA ] a glycyl-[tRNA ] an L-tryptophanyl-[tRNA ] an L-valyl-[tRNA ] an L-glutamyl-[tRNA ] an L-prolyl-[tRNA ] an L-isoleucyl-[tRNA ] an L-glutaminyl-[tRNA ] an L-leucyl-[tRNA ] an L-histidyl-[tRNA ] an L-threonyl-[tRNA ] an L-alanyl-[tRNA ] an L-cysteinyl-[tRNA ] an L-aspartyl-[tRNA ] fatty acid glyoxysomal citrate glucosyltransferase beta chain beta- type ATPase Yta7 Saccharomyces cerevisiae: PC22G19270 cerevisiae: acid permease 2-enoyl-[acp] carrier-protein) α hydratase Aco1 - glkA - epimerase Rpe1 β-D-glucose- 6-phosphate β nucleotidyltransferase pyrophosphate Bacillus subtilis: Ste14 - Aspergillus niger: dehydrogenase Saccharomyces Mycobacterium kinase NDK-1 amino acid amino acid 4 -hydroxymethyl- squalene synthase - Cucurbita PC13G08170 β -D-glucose- like protein SCS - Trichomonas - Saccharomyces cerevisiae: synthase reductase RhlG biosynthesis - Neurospora synthase β α biosynthesis initiation I Saccharomyces Aspergillus - Saccharomyces 6-phosphate -D-fructofuranose Cca1 - Saccharomyces synthase FPPS PC16G12960 Saccharomyces PC21G22810 Lpd1 - cerevisiae: smegmatis: - Neurospora PC16G01200 glycolate PC22G23040 enoyl-[acyl- 4 -methyl-5 - sp: PC12G00660 D-gluconate 6-phosphate An07g06430 - vaginalis: PC20G10080 cerevisiae: PC20G00570 T32M21.120 - Pseudomonas lovC - crassa T32M21.120 monooxygenase - cerevisiae: PC22G02000 mannose-6- niger: cerevisiae: cerevisiae: PC21G19060 - Gibberella cerevisiae: [+ 7 isozymes] Saccharomyces PC22G04340 PC16G00450 crassa: oxidase GOX - [+ 2 isozymes] carrier-protein] cholesta-8,24- Rattus norvegicus: acetyl-CoA phosphate fructokinase: Aspergillus niger: [+ 2 isozymes] PC21G11110 [+ 2 isozymes] [+ 5 isozymes] -Arabidopsis aeruginosa: Aspergillus inosine-5'- -Arabidopsis β 2-oxoglutarate PC22G23550 PC12G00550 fujikuroi: PC13G04360 3-phospho- cerevisiae: [+ 5 isozymes] PC21G15880 Mus musculus: Fe 2+ reductase: dien-3 -ol mitochondrial PC22G23550 PC12G16320 a 3-oxooctadecanoyl-[acp] a [protein] C-terminal thaliana: [+ 4 isozymes] PC22G03680 terreus: phosphate dicarboxylic thaliana: PC22G15550 dehydrogenase: isomerase Pmi40 PC21G15240 [+ 3 isozymes] D-glycerate PC20G04720 an acetylated dGTP PC18G01590 dolichyl-diphosphooligosaccharide biosynthesis Carbohydrate Biosynthesis PC14G00080 aconitase hydroxylase β-D-glucose- D-xylulose- a tRNA S-farnesyl-L- PC12G06970 a [lipoyl- [+ 5 isozymes] 10-oxogeranial a cis,cis-PC14G00090 amino acid gluconeogenesis I glycogen biosynthesis PC12G06970 (S)-2,3- PC20G01630 - Saccharomyces D-fructose- a 3-oxooctadecanoyl- histone a cis,cis- a proteinogenic a proteinogenic UDP-galactose biosynthesis (salvage pathway from galactose using UDP-glucose) Aco1 - Saccharomyces 6-phosphate 5-phosphate containing a GDP succinyl-CoA [+ 2 isozymes] ADP H + cysteine methyl ester carrier protein] delta19,31- glyoxylate permease Dip5 - II (from UDP-D-Glucose) enoyl epoxysqualene malonyl-CoA cerevisiae: 6-phosphate a 6-(D-glucose-1-phospho) phosphate phosphate [acp] delta11,29- amino acid amino acid α β cerevisiae: PC13G03110 UMP 3' CCA end + malate reductase of a 3-oxododecanoyl-[acp] 4 -formyl-4 - glycolysis III Glycolysis PC13G12020 ADP phosphate H 3-hydroxy C50:2-[acp] Saccharomyces a dolichyl phosphate α α lanosterol -D-mannosyl-[glycoprotein] dehydrogenase -D-glucose -D-glucose 1-phosphate the lovastatin methyl-5α- S-malonyltransferase glycolysis I D-fructose- 2,3- C48:2-[acp] cerevisiae 1-phosphate synthase erg7p - citrate homolog Mae1 - biosynthesis 3-oxoacyl-(acyl- cholesta-8,24- fabD - Bacillus β 6-phosphate dehydrokievitone UTP-glucose- Schizosaccharomyces -D-glucose β-D-glucose- UDP-N-acetylglucosamine- mannosyltransferase UDP-glucose:dolichyl- Saccharomyces lovC - carrier-protein) dien-3β-ol subtilis: PC20G00410 dicarboxylic 1-phosphate UTP-glucose- pombe: PC22G14100 6-phosphate -dolichyl-phosphate N- Alg1 - Saccharomyces phosphate cerevisiae: α-D-galactose Aspergillus reductase fabG - glucokinase Inorganic Nutrient Metabolism amino acid (S)-malate uridylyltransferase 1-phosphate CTP a 5'-(5'- an (S)-2- 2-pyrone-4,6- a cis,cis- N'-hydroxymethyl- a trans-delta2- a (1->4)- a proteinogenic a proteinogenic acetylglucosaminephosphotransferase cerevisiae: glucosyltransferase PC21G20250 pyrimidine ribonucleotides Nucleoside and Nucleotide Biosynthesis terreus: Bacillus subtilis: lanosterol a malonyl-[acp] glkA - a phosphatidylcholine a sterol dimethylallyl diphosphate H O 1-aminocyclopropane- a dolichol ATP an mRNA an alcohol acetyl-CoA H O L-sorbopyranose a (2E)-docos- digallate permease Dip5 - Ugp1 - uridylyltransferase purine nucleotides de novo biosynthesis II pyrimidine deoxyribonucleotides de novo biosynthesis I glucose-6- prephytoene diphosphate a tRNA 2 triphosphoguanosine) 2 hydroxycarboxylate dicarboxylate delta17,29-3- norcotinine cis,cis-delta15,27- α-D-glucan amino acid amino acid Alg7 - Saccharomyces PC22G00440 Alg5 -Saccharomyces galactokinase Gal1 de novo biosynthesis PC14G00090 PC16G12960 α synthase erg7p - Aspergillus cyanate degradation diphosphate 1-carboxylate 2-enoyl-[acp] Saccharomyces NADP-dependent Saccharomyces Ugp1 - 4 -carboxy- phosphate urea cycle nitrate reduction V (assimilatory) geranylgeranyl -(nucleotide)-[mRNA]mRNAcap- thermostable alcohol glycolate 2-pyrone-4,6- oxo-C48:2-[acp] phenylacetate sorbitol C46:3-[acp] extracellular precursor cerevisiae: PC15G00540 cerevisiae: -Saccharomyces β α Schizosaccharomyces niger: phosphate phosphate sulfite 1-aminocyclopropane- NADPH- enoyl mitochondrial cerevisiae mannose malate cerevisiae: Saccharomyces α CDP [+ 5 isozymes] 4 -methyl-5 - phosphatidylethanolamine isomerase Pgi1 - thiosulfate transferase type II beta- dolichol guanine-N7- dehydrogenase oxidase GOX - dicarboxylic acid hydroxylase utilization alpha-amylase of tannase - PC22G16060 mitochondrial cerevisiae: bicarbonate 5-phospho- -D-ribose 1-diphosphate a decanoyl-[acyl- pombe [putative PC22G23550 utilization in cell acquisition oxidation IV phosphatidylcholine- 1-carboxylate poly(A) acetyl-CoA dependent reductase of enoyl-CoA phospho-dolichol dehydrogenase PC21G12790 cerevisiae: cholesta-8,24- biosynthesis II Saccharomyces cyanate disproportionation subunit RABGGTB - Homo tRNA inorganic kinase Sec59 - methyltransferase adhT - Bacillus Mus musculus: hydrolase LigI - pahA - protein sou2 amyA/amyB Aspergillus N-acetyl-α-D-glucosaminyl- malate carrier protein] a (3R)-3- β sequencing error]: β nitrate ammonia wall regeneration sterol O- deaminase,acs - polymerase pla1p - hydrolase Ach1 - beta-ketoacyl the lovastatin hydratase synthase dpm1 mdh - Homo UDP-D-glucose PC13G10140 PC21G12790 amidophosphoribosyltransferase ribonucleoside- ribonucleotide dien-3 -ol -D-glucose- cerevisiae: pgi cyanate lyase arg III (rhodanese) a phosphate isopentenyltransferase pyrophosphatase Saccharomyces stearothermophilus: PC22G19270 Sphingomonas Penicillium - Candida - Aspergillus oryzae: aminoalcoholphosphotransferase diphosphodolichol β dehydrogenase arginine-specific hydroxydodecanoyl-[acp] PC06G01230 a phosphate sulfite acyltransferase like sapiens: PC21G08870 Penicillium citrinum: CaAbd1 - Schizosaccharomyces Saccharomyces reductase RhlG biosynthesis ECHS1 gly gly - Hypocrea a dolichyl -D- sapiens: Ade4 - Saccharomyces diphosphate reductase suc22p - hypothetical 3- an acetoacetyl-[acp] 6-phosphate cynS -Escherichia monoester Ipp1 - PC22G24580 paucimobilis: chrysogenum: albicans: niger: PC21G17360 AAPT1 - Glycine max MDH - Mus glycogenin 1 carbamoyl- ethanolamine D-fructose- nitrate reductase thiosulfate monoester acid sulfite like protein An16g03640 geranylgeranyl diphosphate Mod5 - Saccharomyces PC22G02500 cerevisiae: Candida albicans: pombe: PC06G01240 cerevisiae: glycolate - Pseudomonas lovC - - Rattus jecorina: glucosyl phosphate PC13G04510 α-D-galactose 1-phosphate UDP-D-glucose acetaldehyde biosynthesis I cerevisiae: PC20G13330 reductase: Schizosaccharomyces oxoacyl-(acyl- 3-hydroxyacyl- lanosterol coli: PC21G18920 acid Saccharomyces PC16G13250 PC22G02230 PC22G00670 PC22G12340 musculus: GYG - Homo phosphate ethanolamine glucose-6- 6-phosphate (NADPH) niaD - glutamine glutamate phosphatase protein - Aspergillus niger: geranylgeranyltransferase I cerevisiae: PC12G04480 PC18G03500 a 5'-(N 7 -methylPC12G09290 5'- [+ 11 isozymes] PC12G03130 oxidase GOX - (1Z,3Z)-4- aeruginosa: Aspergillus norvegicus: [+ 2 isozymes] PC13G10270 PC21G07530 pombe: PC21G07530 carrier-protein) [acp] dehydrase: kinase EKI1 - Homo phosphate carbamate dehydrogenase phosphatase cerevisiae: ACC deaminase an aldehyde Mus musculus: [+ 9 isozymes] [+ 2 isozymes] [+ 6 isozymes] PC21G22090 sapiens: synthase β 3-keto-4- arginase argA Aspergillus niger: synthase Gln1 - aphA - An12g06030 PC12G15540 beta chain GGTase-I - Rattus triphosphoguanosine)- hydroxybuta- PC22G03680 terreus: PC22G21270 gallate N-acetyl-β-D-glucosaminyl- 5-phospho- -D-ribosyl-amine synthase PC14G00080 thiosulfate aphA - PC20G07230 -Penicillium CDP or ketone 5-dehydro- aminoalcoholphosphotransferase PC18G02120 pyruvate subunit Cpa2 - dCDP methylzymosterol sapiens: PC13G08470 isomerase Pgi1 - fructose-1,6- cyanate lyase -Aspergillus PC21G02590 Saccharomyces gdhA-Penicillium Aspergillus - Aspergillus norvegicus: PC14G01660 a dolichyl (ribonucleotide)-[mRNA] an mRNA PC18G01590 1,3-diene-1,2,4- norcotinine PC14G00090 maltohexaose a (3Z)-docos- gly gly (1->4)-N-acetyl- a dolichyl β-D- malate [+ 3 isozymes] T32M21.120 phosphoryl-ethanolamine argininosuccinate ammonia sulfurtransferase Aspergillus citrinum: a cis,cis-[+ 5 isozymes] D-fructose a cis,cis- AAPT1 - Glycine max ethanol Saccharomyces phosphoribosylamine- a (2E)-dodec-2-enoyl-[acp] Saccharomyces bisphosphatase 6-phosphofructokinase cynS -Escherichia niger: nitrate reductase cerevisiae: chrysogenum: ficuum: niger: prenyl-tRNA phosphate acetate a 2-oxo acid tricarboxylate 3-enoyl-[acp] α-D-glucosaminyl- α -Arabidopsis cholesterol biosynthesis lyase ASAL - TST - Homo all-trans-phytoene PC22G25060 delta17,29-3- delta15,27- mannosyl phosphate dehydrogenase, an -D-glucosyl- cerevisiae: glycine ligase: PC22G21160 nucleoside- 24,25- cerevisiae: pgi fbpA - Aspergillus pfkA - Aspergillus PC13G09710 PC22G03070 gdhA ficuum: PC13G01940 a 1-acyl-2-lyso- pyruvate III (via desmosterol) coli: PC21G18920 ammonia- (NADPH) niaD or PC22G09580 a steryl-ester + 2-oxobutanoate hydroxyC48:2- C46:2-[acp] diphosphodolichol NAD-requiring: [glycogenin] PC22G20150 UDP thaliana: dihydrolanosterol CTP:phosphoethanolamine D-fructose- fructose-1,6-oryzae: niger: PC12G13500 Candida albicans: sapiens: PC22G09580 glycerophosphocholine phosphate H oxaloacetate decarboxylase alcohol dehydrogenase phosphoribosylamine- diphosphate fatty-acyl-CoA synthase dependent niiA-Penicillium [+ 2 isozymes] [+ 4 isozymes] sulfate [acp] β-mannosyltransferase: PC13G04510 PC12G06970 4-α- (2E,6E)-farnesyl cytidylyltransferase ET 6-phosphate bisphosphatePC22G05750 CO PC20G06010 PC21G13770 [+ 4 isozymes] allantoin glycogenin 1 dcpY - Aspergillus glycine ligase: PC20G11650 kinase NDK-1 beta chain fas1p - 2 L-arginino- chrysogenum: phosphate PC22G00440 UDP-glucose 4- adh1p - arginine-specific CTP ribonucleotide ribonucleoside- a 3- methylzymosterol - Rattus norvegicus: aldolase - glycolysis II L-ornithinecarbamoyl- glt phosphate transport GYG - Homo parasiticus: - Neurospora salvage pathways of pyrimidine ribonucleotides Schizosaccharomyces diphosphatedehydrosqualene 6-phosphofructokinase succinate PC13G11410 β β UDP-glucose- epimerase Gal10 Schizosaccharomyces carbamoyl- reductase suc22p - diphosphate oxododecanoyl- PC20G00270 fructose-1,6- hypothetical phosphate gln allantoin protein Dal4 - allantoin -D-Man-(1->4)- -D- itaconate pyruvate phosphoenolpyruvate sapiens: 5-phospho-ribosyl-glycineamide crassa: pombe: PC14G00740 α pfkA - Aspergillus Thermus thiocyanate sulfite α-D-galactose N-acetyl-O- 6-O-cis-methoxy- - Saccharomyces PC18G01490 pombe: PC12G13440 phosphate Schizosaccharomyces reductase: [acp] 4,4-dimethyl-14 - synthase: D-fructose- argininosuccinate synthase: a (2E)-2- 2-pyrone-4,6- ADP-ribose a ribonucleoside 2+ Saccharomyces GlcNAc-(1->4)-α-D- biosynthesis gluconeogenesis carboxykinase KlPck1 hexose-1-phosphate PC21G15880 cytidine CDP-ethanolamine aquaticus: bisphosphate carbonic anhydrase nitrite pyruvate a 2,2-dialkylglycine a phosphatidylcholine 2-oxobutanoate succinate an aryl sulfate a phenol a reduced electron benzoate an arylamine cotinine bupropion mycolyl-trehalose- a phenol Fe PC18G02120 cerevisiae: [+ 3 isozymes] [+ 11 isozymes] synthase phosphoribosylglycinamide pombe: PC21G07530 PC21G07530 3-oxoacyl- fatty-acyl-CoA synthase hydroxymethyl- PC21G13930 niger: PC12G13500 6-phosphate synthase Arg1 - PC21G21940 1-phosphate UTP arg demethylpuromycin enoyl-CoA dicarboxylate diphosphate cerevisiae GlcNAc-diphosphodolichol - Kluyveromyces (1,4-α-D-glucosyl) uridylyltransferase: α PC20G09750 fructose-1,6- SPBP8B7.05c - transferring flavoprotein benzoate 4- cDNA O- arylamine N- 6-phosphate PC21G10370 subunit Cpa2 - formyltransferase (acyl-carrier- beta chain fas1p - 4 -hydroxymethyl- 5α-cholesta- presqualene diphosphate fructose-1,6- Saccharomyces electron-transfer L-amino-acid oxidase peroxisomal 2-pyrone-4,6- phenylacetate phenylacetate trehalose-6- nucleoside- norsolorinic cell surface mannosyltransferase pyruvate lactis: PEPCK -glucosyl PC15G00140 α bisphosphatase 6-phosphofructokinase Schizosaccharomyces carbamoyl- monooxygenase methyltransferase acetyltransferase n dCTP dUDP cytidine 5 -cholesta- 8-en-3β-ol bisphosphate fructose- Nucleoside and Nucleotide Degradation 2,4-dienoyl- dicarboxylic acid hydroxylase hydroxylase diphosphate acid reductase ferroxidase allantoin 1 PMT1 - Candida pyruvate pyruvate [+ 4 isozymes] Saccharomyces Ade8 -Saccharomyces cytosine protein) Schizosaccharomyces fbpA - Aspergillus pfkA - Aspergillus pombe: PC22G06300 cerevisiae: phosphate 2,2-dialkylglycine calcium-independent O-succinylhomoserine arylsulfate UDP-glucose- flavoprotein- lox - Neurospora Nudix (nucleoside phosphate glucogenin acetaldehyde deaminase - 8,24-dien-3β-ol squalene dihydroxyacetone bisphosphate ornithine cytochrome P450 53 mt-I - Aspergillus -Gallus gallus: CoA reductase hydrolase LigI - pahA - pahA - kinase NDK-1 norA - precursor Fet3 - transport albicans: PC12G05130 carboxylase pyc - cerevisiae: cerevisiae: PC22G21160 reductase pombe: PC21G10870 oryzae: niger: PC12G13500 PC12G11190 decarboxylase phospholipase A2 (thiol)-lyase met-7 sulfotransferase hexose-1-phosphate ubiquinone crassa: PC20G15180 diphosphate) phosphatase malate phosphoenolpyruvate hypothetical nucleoside- CMP Homo sapiens: synthase: a phosphatidylethanolamine phosphate aldolase Fba1 - carbonic anhydrase carbamoyltransferase bphA - Aspergillus parasiticus: PC22G06840 involved in Sphingomonas Penicillium Penicillium - Neurospora Aspergillus Saccharomycesallantoin protein Dal4 - allantoin Aspergillus niger: PC06G02240 fabG - Bacillus fructose-1,6- PC22G05750 fructose-1,6- purine nucleotides degradation IV (anaerobic) structural protein - Homo sapiens: chain - Neurospora like protein uridylyltransferase oxidoreductase like L-amino-acid oxidase hydrolase Ysa1 - like protein mannosyltransferase dehydrogenase 5'-phosphoribosyl-N-formylglycineamide dCTP deaminase diphosphate PC20G13380 cytosine a dodecanoyl-[acp] PC21G13930 Saccharomyces fructose-1,6- pca1 - Porphyridium argB - Aspergillus niger purine nucleotides degradation III (anaerobic) urate biosynthesis niger: PC22G07440 PC22G01170 arylamine N- sporulation Sps19 paucimobilis: chrysogenum: chrysogenum: crassa: parasiticus: cerevisiae: Saccharomyces PC13G07230 subtilis: 4,4-dimethyl- bisphosphate bisphosphate dgdA - Pseudomonas PC21G00340 crassa: PC20G08350 An13g03160 - Gal7 - protein An16g03910 lox - Neurospora Saccharomyces An11g10990 1 PMT1 - Candida homolog Mae1 - enolase a glucosylated carbamoyl- AF1108 - kinase NDK-1 deaminase α cerevisiae: bisphosphate purpureum: [putative sequencing [+ 3 isozymes] [+ 7 isozymes] acetyltransferase -Saccharomyces PC16G13250 PC22G02230 PC22G02230 PC21G15880 PC22G23540 PC21G16380 cerevisiae oxaloacetate cytidine PC16G12960 4 -formyl- 14α-formyl- squalene aldolase - triose- aldolase - L-citrulline cepacia: PC22G13650 Aspergillus niger: Saccharomyces - Aspergillus niger: crassa: PC16G06420 (1Z,3Z)-4- cerevisiae: - Aspergillus albicans: PC20G07670 Saccharomyces BAC82549- glycogenin phosphate phosphoribosylformylglycinamidine UTP Archaeoglobus - Neurospora codA - α PC18G01220 PC21G10590 error]: PC22G18390 [+ 6 isozymes] cerevisiae: a ribonucleoside 3+ α β deaminase - 5 -cholesta- 5α-cholesta- Thermus phosphate- purine PC16G11630 cerevisiae: PC13G10690 4-hydroxybenzoate 2-ketoarginine N-acetylpuromycin -Gallus gallus: hydroxybuta- PC22G16110 [+ 9 isozymes] [+ 9 isozymes] niger: [+ 2 isozymes] Fe -D-Man-(1->3)- -D- cerevisiae: Penicillium acetaldehyde synthase purL -Escherichia fulgidus: crassa: CDP Escherichia [+ 5 isozymes] Thermus inosine-5'- PC22G15030 N'-hydroxymethyl- triphosphate an aromatic anion transporter β glyoxysomal glycogen aspartate Homo sapiens: a (3R)-3- hypothetical 3- 8,24-dien-3β-ol β squalene aquaticus: bicarbonate purine O-succinyl-L- an oxidized electron PC20G04880 1,3-diene-1,2,4- hydroxybupropion PC20G08480 Man-(1->4)- -D-GlcNAc- chrysogenum: biosynthesis II coli: PC21G18880 coli: 8-en-3 -ol isomerase tpiA aquaticus: guanine phosphate PC15G00140 a (2E,4E)-2,4- norcotinine trehalose- aldehyde YNL275w - citrate synthase PC21G20250 synthase - α carbamoyltransferase: PC21G20640 PC21G15880 nucleoside- PC16G01040 oxoacyl-(acyl- monooxygenase - PC20G09750 a 1-acyl-2-lyso- α homoserine transferring flavoprotein N-acetylarylamine an anion an anion (1->4)-α-D-GlcNAc- -D-glucose 1-phosphate UDP-D-galactose PC21G04150 hydroxydodecanoyl- from patent PC20G09750 IMP a dialkyl ketone ala -linolenate dienoyl-CoA tricarboxylate D-ribose 5- cis-methoxy- Saccharomyces - Cucurbita sp: PC14G01740 Neurospora PC22G20150 5-phosphoribosyl-N-formylglycineamidine diphosphate carrier-protein) Rattus norvegicus: 6,8-dihydroxypurine glycerophosphocholine AMP diphosphodolichol NADP-dependent pyruvate [acp] laurate fatty acid elongation -- saturated fructose- WO8704464- dehydrogenase a phenol an aryl sulfate phosphate mono-mycolate cerevisiae mannosyltransferase PC12G00660 malate 2-phospho- crassa: dUTP kinase NDK-1 uridine cytosine 3-hydroxyacyl- synthase α PC22G15550 fructose- IMH3 -Candida UDP-D-galactose pyruvate N-carbamoyl- 4 -carboxy- 4,4-dimethyl- bisphosphate A -Aspergillus 1 PMT1 - Candida dehydrogenase D-glycerate PC21G15690 bifunctional purine - Neurospora deaminase [acp] T32M21.120 α bisphosphate guanine deaminase albicans: citrate decarboxylase L-aspartate dUTP 5 -cholesta- 5-α-cholesta- aldolase Fba1 - niger: anion transporter albicans: PC12G05130 phosphoglycerate a glucosylated synthase like protein crassa: FCA1 - dehydrase: -Arabidopsis β (S)-2,3-epoxysqualene aldolase Fba1 - like protein mdh - Homo pyrophosphatase 8,24-dien-3 -ol 8,14-dien-3-β-ol an acetoacetyl-[acp] Saccharomyces PC21G03400 8-hydroxypurine PC18G05320 all-trans- a 2'- 5-exo- pyrroline-hydroxy- a (2E,4Z)-2,4- a (6Z)-3- 6-O-trans-keto- ammonium YNL275w - mutase pgm - glycogenin trehalose biosynthesis II dcpY - dihydroorotase An15g00570 - Aspergillus PC21G15880 Candida PC14G00080 thaliana: Saccharomyces hypoxanthine An14g01140 - hypoxanthine O-succinyl-L- isopentenyl isopentenyl a pectin a monoamine 4-nitrobenzaldehyde L(or D)-O- starch an aldehyde a 2-oxo acid an anion an anion mannosyltransferase mitochondrial sapiens: DUT1 - Candida lanosterol cerevisiae: dihydroxyacetone IMP cys geranyl-geranyl a tRNA deoxyribonucleoside hydroxycamphor a tRNA carboxylate dienoyl-CoA L-homoserine oxooctadec- mycolyl-trehalose- hydroxide Saccharomyces Bacillus subtilis: Aspergillus Ura4 - niger: PC20G11650 albicans: PC12G06970 cerevisiae: Aspergillus niger: urate homoserine diphosphate diphosphate [DNA] phosphoserine 1 PMT1 - Candida aconitate PC13G04510 1,4-alpha-glucan GDP-glucose biosynthesis albicans: a (2E)-dodec- synthase erg7p - PC18G01220 phosphate C1 Compound Utilization and Assimilation dehydrogenase diphosphate 5'-triphosphate thermostable alcohol norsolorinic acid delta-1-pyrroline- peroxisomal 6-enoyl-[acp] extracellular 6-phosphate aldehyde pyruvate nitrite cerevisiae α parasiticus: Saccharomyces CTP PC16G10090 D-glyceraldehyde- PC18G01220 PC16G11230 tRNA (cytosine-5-)- holocytochrome- NADPH- phosphoserine trehalose-6- albicans: PC20G07670 PC12G16040 branching ADP-D-glucose -D-glucose 6-phosphate 5-aminoimidazole ribonucleotide PC22G25560 2-enoyl-[acp] IMH3 -Candida dehydrogenase reductase norA 5-carboxylate 2,4-dienoyl- alpha-amylase dehydrogenase decarboxylase reductase α-D-Man-(1->3)-[α-D-Man- hydratase Aco1 - (S)-malate PC18G01490 cerevisiae: 5α-cholesta- 4,4-dimethyl- Schizosaccharomyces 3-phosphate pectin methylesterase monoamine oxidase methyltransferase c synthase cyt- dependent phosphatase phosphate 3-phospho- enzyme Glc3 - uridine triose- guanine deaminase xanthine xanthine albicans: adhT - Bacillus - Aspergillus dehydrogenase CoA reductase amyA/amyB ALDH3 - Rattus dcpY - (NADH) niiA (1->6)]-α-D-Man-(1->4)- Saccharomyces β-D-glucose [+ 3 isozymes] PC06G00380 dUMP enoyl-[acyl- a 3-oxotetradecanoyl-[acp] 8,24-dien-3-one 5α-cholesta- pombe: PC22G14100 formaldehyde assimilation III (dihydroxyacetone cycle) O-succinylhomoserine trans- tRNA retrotransposon pme1 - Aspergillus maoN -Aspergillus Ncl1 - 2 - Neurospora beta-ketoacyl Ser2 - phosphatase vacuolar D-glycerate Saccharomyces aminoimidazole kinase Urk1 - triose- glyceraldehyde- phosphate- formaldehyde oxidation V formaldehyde like protein dehydrogenase dehydrogenase PC13G07630 stearothermophilus: parasiticus: p5cdh - Homo involved in - Aspergillus norvegicus: Aspergillus - Aspergillus β-D-GlcNAc-(1->4)-α-D- cerevisiae: mitochondrial glucokinase trehalose-6-phosphate acetaldehyde carrier-protein] 8-en-3-β-ol lanosterol a 3-oxoacyl-[acp] xanthosine- (thiol)-lyase met-7 pentaprenyltranstransferase isopentenyltransferase like protein aculeatus: PC20G13370 niger: PC21G09410 Saccharomyces crassa: reductase RhlG Saccharomyces like protein H(+)/Ca(2+) phosphoglycerate cerevisiae: ribonucleotide carboxylase thymidylate Saccharomyces phosphate- 3-phosphate isomerase tpiA (tetrahydrofolate pathway) oxidation IV (thiol- An14g01140 - hxA - Aspergillus hxA - Aspergillus PC22G24580 PC22G23540 sapiens: sporulation Sps19 niger: PC22G03630 parasiticus: nidulans: 2+ 2+ GlcNAc-diphosphodolichol PC22G02000 malate glkA - synthase subunit 1 (S)-dihydroorotate reductase: 3-oxoacyl-(acyl- synthase erg7p - 6,8-dihydroxypurine 5-phosphate chain - Neurospora Coq1 - Saccharomyces Mod5 - Saccharomyces An08g10220 - pectin methylesterase cerevisiae: PC22G25750 - Pseudomonas cerevisiae: An11g10990 Ca exchanger Vcx1 Ca kinase pgkA- PC21G10060 ADE2 - Candida synthase CATSA cerevisiae: uracil NADPH- isomerase tpiA dehydrogenase from patent D-ribulose-5-phosphate independent) Aspergillus niger: nidulans: nidulans: [+ 3 isozymes] [+ 11 isozymes] [+ 2 isozymes] PC21G19920 -Saccharomyces PC22G12340 [+ 2 isozymes] PC18G01490 PC13G11420 mitochondrial dehydrogenase Aspergillus tpsA - Aspergillus PC14G00080 carrier-protein) Schizosaccharomyces crassa: PC20G08350 cerevisiae: PC20G07830 cerevisiae: PC12G04480 Aspergillus niger: pme1 -Aspergillus PC16G12760 aeruginosa: PC20G03210 - Aspergillus - Saccharomyces Penicillium glabrata: PC22G04460 - Candida PC22G09180 phosphoribosyltransferase dependent from patent gpdA - WO8704464- formaldehyde PC14G00380 PC22G06330 PC22G06330 2,5- a 5-methylcytosine cerevisiae: [+ 3 isozymes] [+ 6 isozymes] aconitase MDH - Mus glycogen niger: niger: PC22G02020 reductase fabG - α pombe [putative formaldehyde 5-nucleotidase PC12G09920 aculeatus: PC15G01810 4-nitrobenzyl alcohol [+ 2 isozymes] PC22G03680 serine niger: an acid [+ 3 isozymes] nitrite cerevisiae chrysogenum: pgkA 5-phospho- 5-amino-1-(5-phospho-D- albicans: upp - Bacillus enoyl zymosterol 4 -hydroxymethyl- beta-ketoacyl WO8704464- Aspergillus niger: A -Aspergillus diketocamphane in tRNA PC22G15030 2-oxobutanoate a large- PC22G23550 6 L-erythro-4- PC20G08480 an aldehyde a (mannosyl) -(N- hydroxylase Aco1 musculus: β α-D-ribose 1- PC13G06460 caldolyticus: PC21G01810 reductase of Bacillus subtilis: 4β-methyl- sequencing error]: hypothetical 3- A -Aspergillus glutathione- 5NTD_DISOM geranylfarnesyl a tRNA containing N - an aldehyde a primary amine a (3E)-3- a (3R,6Z)-3-[+ 5 isozymes] branched glucan trehalose- 4 -D-glucose- ribosyl)imidazole-4-carboxylate reductase RhlG PC21G14560 niger: succinate hydroxy-glutamate hypothetical acetylglucosaminyl) - Saccharomyces PC21G22090 trehalose 6-phosphate PRPP biosynthesis I orotate diphosphate PC16G12960 S-adenosyl-L- 5α-cholesta- PC06G01230 oxoacyl-(acyl- independent xanthine - Discopyge L-cystathionine dimethylallyladenosine hydroxyoctadec- trans-keto- 2 1,3-diphosphateglycerate 6-phosphate uracil the lovastatin - Pseudomonas niger: PC21G03400 5,10-methylenetetrahydrofolate diphosphate enoyl-CoA Ca2+/H+ cerevisiae: phosphoribosylaminoimidazole- dTMP methionine:delta24- β carrier-protein) urate ommata: [DNA] methanol a pectate mono-mycolate -diphosphodolichol [+ 3 isozymes] phosphoribosyltransferase biosynthesis [+ 5 isozymes] 8-en-3 -ol aeruginosa: PC21G03400 formaldehyde guanine 6-enoyl-[acp] antiporter D-ribose 5- succinocarboxamide sterol-C- lanosterol synthase dihydroxyacetone D-glyceraldehyde- 1,3-diphosphateglycerate PC22G00320 Ca 2+ Ca 2+ PC13G03110 trehalose-6-phosphate orotidine-5- thymidylate Fur1 - Saccharomyces lovC - a (3R)-3- ribulose-5-phosphate- trifunctional C1- dehydrogenase YNL321w - oxaloacetate glyceraldehyde- phosphate synthase: PC22G04460 methyltransferase T32M21.120 PC22G03680 phosphate 3-phosphate D-glyceraldehyde- GDP-mannose biosynthesis phosphatase like protein ribose-phosphate monophosphate kinase CDC8 - cerevisiae: PC20G00460 Aspergillus hydroxytetradecanoyl-[acp] ribose 5-phosphate epimerase Rpe1 tetrahydrofolate synthase fdhA - Saccharomyces cis-aconitate 3-phosphate α 5'-phosphoribosyl-4-(N- [+ 5 isozymes] 3-phosphate 2 6-O-cis-keto- -D-glucose An11g10990 - Aspergillus pyrophosphokinase pyrophosphorylase UMP uracil terreus: - Glycine max: -Arabidopsis Other glyceraldehyde- phosphoglycerate isomerase: PC21G20440 - Saccharomyces Ade3 - Saccharomyces Pseudomonas xanthosine β UDP-D-glucose a (1->4)- UDP-D-glucose N -succinyl- a [protein]-L- adenosine34- α-D-Man-(1->2)-α-D- phosphoenolpyruvate dehydrogenase Homo sapiens: 3-hydroxyacyl- 4α-formyl- a (3R)-3- xanthine 4-ureido-5-imidazole carboxylate glutathione a 1,3- -D-glucan 3-dimethylsulfoniopropionaldehyde a 1-lysophosphatidylcholine α a quinone apiitol O-demethylpuromycin 4-acetamidobutanal chloroacetate a cis-delta19-3- an aromatic (S)-mandelate (S)-nicotine Peptide cerevisiae β-D-glucose- 6-phosphate niger: PC20G08480 - Ajellomyces succinocarboxamide)-5-aminoimidazole PC21G10300 a 2,3,4-saturated thaliana: 3-phosphate kinase pgkA- glyceraldehyde- ribose-5-phosphate putida: guanine deaminase hypoglycin A -D-glucan L-glutamate 5- β-isoaspartate of-tRNA(Arg2) mycolyl-trehalose- Man-(1->2)-α-D-Man- carboxykinase KlPck1 gpdA - Prs2 - Saccharomyces PC21G15930 PC14G00090 [acp] dehydrase: 4β-methyl- 4,4-dimethyl-14α- hydroxyacyl-[acyl- cerevisiae: PC12G00550 cerevisiae: PC20G03600 dehydrogenase oxo-C38:1-[acp] amino acid tRNA-specific potassium- 6-phosphate phosphoglucomutase: capsulatus: adenylosuccinate fatty acyl-[acp]PC12G06970 dehydrogenase Penicillium 3-phosphate isomerase rpiB - PC21G08510 like protein aldehyde quinone reductase like transcription factor ste11p cDNA O- aldehyde semialdehyde protein-L- 2-haloacid NADPH- 6-phosphate hypothetical phenylacetate calpain nCL- (1->3)-[α-D-Man-(1->6) - Kluyveromyces Aspergillus niger: glucose-6- trehalose cerevisiae: PC14G00080 sterol 5α-cholesta- hydroxymethyl-5α- carrier protein] aspartate hxA - Aspergillus delta-1-pyrroline- aromatic adenosine trehalose-6- dependent PC18G01390 PC15G00490 lyase ADSL - Homo dTDP glycerol-3-phosphate shuttle gpdA - chrysogenum: pgkA dehydrogenase Escherichia coli: 5,10-methenyltetrahydrofolate An14g01140 - 1,3-beta-glucan dehydrogenase glycogen protein An12g00170 -Schizosaccharomyces methyltransferase dehydrogenase isoaspartate(D- halidohydrolase dependent protein RTS- hydroxylase 3 like protein ]-β-D-Man-(1->4)-β-D- lactis: PEPCK PC21G14560 phosphate PC22G06960 a dodecanoyl-[acp] transmethylase 8-en-3β-ol cholesta-8,24-dien-3β-ol degradation II [+ 11 isozymes] nidulans: lysophospholipase- 5-carboxylate aminotransferase deaminase phosphate sodium-calcium phosphoglucomutase: sapiens: PC20G14240 nucleoside- ERG6 - Candida Aspergillus niger: gpdA - D-ribose 5-phosphate PC22G21440 D-xylulose-5-phosphate formate Aspergillus niger: gamma- synthase gs-1 aldA - Aspergillus synthase - - Aspergillus niger: pombe: PC22G05580 mt-I - Aspergillus aldA - aspartate) O- IVa - Burkholderia beta-ketoacyl I Aro8 - beta - Homo pahA - An11g02950 GlcNAc-(1->4)-α-D- itaconate dihydroxyacetone D-glyceraldehyde- isomerase Pgi1 - 5-phospho-[+ 2 isozymes] a (2E)-tetradec-2-enoyl-[acp] 3-phospho- methenyltetrahydrofolate PC22G06330 transacylase - dehydrogenase subunit Tad1 - phosphatase Ca 2+ exchanger Ca 2+ phosphoenolpyruvate dihydroxyacetone PC21G14560 Aspergillus niger: PC16G11230 Glutamyltranspeptidase - Neurospora niger: PC21G22810 Neurospora PC21G11670 transcription factor ste11p parasiticus: Aspergillus niger: methyltransferase cepacia: reductase RhlG sapiens: Penicillium - Aspergillus GlcNAc-diphosphodolichol phosphate 3-phosphate Saccharomyces PC20G04410 α-D-ribose 1- orotidine-5'- aminoimidazole carboxamide ribonucleotide diphosphate albicans: asp D-glycerate cyclohydrolase: 4-amino-5-imidazole carboxylate xanthine Rattus norvegicus: p5cdh - Homo Saccharomyces Saccharomyces like protein like protein α phosphate kinase NDK-1 PC12G14840 phosphate PC21G14560 guanine deaminase - Pseudomonas crassa: [+ 7 isozymes] crassa: quinone oxidoreductase -Schizosaccharomyces PC22G01170 PC21G22810 PCMT1 - Mus PC22G05490 - Pseudomonas cerevisiae: PC22G19710 chrysogenum: niger: enolase cerevisiae: pgi -D-glucose diphosphate hypothetical 3- fatty-acyl-CoA synthase 4α-carboxy- α formaldehyde PC20G03600 PC21G16610 sapiens: cerevisiae: An11g10990 An15g06270 - D-fructose- 5-aminoimidazole-4- - Neurospora 4,4-dimethyl-14 - Aspartate 1,3-diphosphateglycerate phosphoglycerate transketolase like protein like protein xanthine aeruginosa: PC22G03740 PC20G00810 dimethylsulfoniopropionate PC21G15690 P1 - Arabidopsis pombe: PC18G06680 [+ 7 isozymes] [+ 7 isozymes] musculus: [+ 3 isozymes] aeruginosa: PC12G11860 [+ 2 isozymes] PC22G02230 PC12G09850 BAC82549- 1-phosphate oxoacyl-(acyl- beta chain fas1p - 4β-methyl- α [+ 2 isozymes] N-acetyl-4- PC21G19920 PC18G02020 - Aspergillus Aspergillus niger fructose-1,6- GDP-mannose 6-phosphate orotidine-5- carboxamide ribotide crassa: fecosterol formyl-5 -cholesta- transaminase: glycerol-3- mutase pgm - 1,3-diphosphateglycerate An02g06430 - Aspergillus dihydroxyacetone 10-formyl-tetrahydrofolate An14g01140 - dehydrogenase [+ 3 isozymes] thaliana: PC06G01800 apiose puromycin PC20G08550 glycolate PC22G03680 an aromatic (R)-mandelate [+ 9 isozymes] Peptide carrier-protein) Schizosaccharomyces α a protein L-β- inosine34-of- niger: ∆ 1'5' potassium- Penicillium bisphosphate phosphate 5 -cholesta- 8,24-dien-3β-ol PC16G02790 glycerol-3- phosphoglycerate aminobutyrate 2 [+ 2 isozymes] nicotine- α-D-Man-(1->2)-α-D-Man- biosynthesis I transformylase Ade17 PC21G15880 laurate enoyl phosphate Bacillus subtilis: niger: PC18G00660 synthase DAS1 - Candida Aspergillus niger: hxA - Aspergillus a semiquinone N - 2-oxo-acid PC20G08480 dependent chrysogenum: aldolase - mannose-6- decarboxylase synthase pombe: PC14G00740 8-en-3β-ol phosphate kinase pgkA- phosphoglycerate β UDP a (1->4)- UDP isoaspartate a cis-delta19-3-[+ 5 isozymes] tRNA(Arg2) -iminium ion (1->2)-α-D-Man-(1->3)-[α- β - Saccharomyces reductase of [+ 6 isozymes] dehydrogenase PC12G16040 transketolase Tkl1 boidinii: PC15G01110 formate-tetrahydrofolate PC14G00380 4-aminoimidazole nidulans: a 1,3- -D-glucan L-1-glycero-3- α succinylglutamate α trehalose-cis-keto- sodium-calcium PC14G01740 Thermus -D-glucose- phosphate pyrA - dTTP T32M21.120 fatty-acyl-CoA synthase oxaloacetate dehydrogenase Penicillium kinase pgkA- hypoglycin B cysteinylglycine a carboxylate -D-glucan -methyl ester hydroxyC38:1- D-Man-(1->3)-α-D-Man- α cerevisiae: PC22G19100 (NAD+) -Saccharomyces ligase: PC20G03600 PC22G06330 phosphocholine mono-mycolate 2+ 2+ 6-phosphate isomerase GDP- -D-glucose -Arabidopsis beta chain fas1p - the lovastatin a trans-2- like protein Penicillium [+ 2 isozymes] [acp] Ca exchanger Ca (1->6)]-β-D-Man-(1->4)- 2-phospho- aquaticus: glucose-6- Aspergillus 4,4-dimethyl-5-α- a 2,3,4-saturated precursor Gpd1 - chrysogenum: pgkA 2-phospho- cerevisiae: PC13G12450 manA - thaliana: Schizosaccharomyces episterol biosynthesis enoyl-[acyl- mitochondrial An08g00210 - chrysogenum: pgkA urate like protein β-D-GlcNAc-(1->4)-α-D- D-glycerate PC20G09750 phosphate niger: phosphoribosyl-formamido-carboxamide 4α-methyl- cholesta-8,14,24- fatty acyl-[acp] Saccharomyces 3-phospho- D-glycerate formate Candida PC12G06970 pombe: PC21G10870 lovC - carrier protein] malate Aspergillus niger: transketolase like protein An15g06270 - GlcNAc-diphosphodolichol phosphoglycerate fructose- isomerase Pgi1 - PC16G14510 5α-cholesta- trien-3-β-ol cerevisiae: D-glycerate 3-phospho- 1,4-α-D- 6-phospho- indole-3- indole an aromatic 3-hydroxy- mannosyltransferase albicans: Aspergillus dehydrogenase enolase An02g06430 - Aspergillus 1 long chain a cis-delta11-3- D-ribose Aspergillus niger Saccharomyces IMP cyclohydrolase: 8-en-3-one PC16G01790 D-glycerate 4-imidazolone trans-caffeate N -acetylspermine 3,4-dihydroxyphenylacetaldehyde a feruloyl-polysaccharide succinate prephenate oxalosuccinate dihydrolipoamide D-gluconate β-alanine cotinine chloride 1 PMT1 - Candida mutase pgm - bisphosphate PC13G08170 Polyprenyl Biosynthesis orotidine 5- terreus: MDH - Mus PC20G06370 phosphoglycerate BAC82549- D-sedoheptulose 7-phosphate D-glyceraldehyde-3-phosphateniger: PC18G00660 galacturonide polyphosphate glycol aldehyde oxo-C30:1-[acp] acetaldehyde primary alcohol stearoyl-CoA cerevisiae: pgi PC22G19100 a 3-oxotetradecanoyl- a myristoyl-[acp] dihydroxy-acetone aldehyde soluble cytoplasmic prephenate precursor of precursor of phosphogluconate aldehyde aldehyde phenylacetate aryl-alcohol mitochondrial ribokinase channel 3 albicans: PC12G05130 Bacillus subtilis: aldolase Fba1 - D-fructose- phosphate PC14G00090 musculus: mutase pgm - Penicillium phosphoglycerate transketolase Tkl1 xanthine cytosolic NADPH- 4-aminobutyrate chloride chloride PC12G16040 Saccharomyces mannose-6- [acp] 5,7,24(28)- Bacillus subtilis: mutase pgm - glycerone kinase dehydrogenase fumarate reductase exopolyphosphatase dehydrogenase mitochondrial dihydrolipoamide dehydrogenase dehydrogenase dehydrogenase hydroxylase oxidase enoyl-CoA like protein clcn3 - Mus mannosyltransferase 6-phosphate superpathway of decarboxylase hypothetical 3- PC21G22090 chrysogenum: -Saccharomyces methanol oxidation to formaldehyde I 4-coumarate-CoA ligase polyamine oxidase PAO - exopolygalacturonase ferulic acid esterase dependent transaminase cerevisiae: phosphate geranyl ergostatrienol 4,4-dimethylzymosterol sn-glycerol- PC12G16040 Bacillus subtilis: isoform I dak1p - aldA - Aspergillus YEL047c - Saccharomyces Ppx1 - Saccharomyces Tyr1 - isocitrate dehydrogenase Gnd1 - ALDH3 - Rattus ALDH3 - Rattus pahA - precursor aao hydratase An15g07500 musculus 1 PMT1 - Candida 3-phospho- mannose-6- geranylgeranyldiphosphate pyrG-Penicillium inosine-5'-phosphate 3-oxoacyl- oxoacyl-(acyl- 4α-methyl- [+ 3 isozymes] PC14G01740 cerevisiae: PC13G12450 4CL - Arabidopsis Zea mays: PC18G02250 pgaX - Aspergillus A faeA -Aspergillus beta-ketoacyl gatA - PC18G01220 isomerase Pmi40 diphosphate C-22 sterol fatty-acyl-CoA synthase 3-phosphate PC12G16040 transaldolase talB Schizosaccharomyces niger: PC21G22810 cerevisiae: PC12G03090 cerevisiae: Saccharomyces dehydrogenase Lpd1 - Saccharomyces norvegicus: norvegicus: Penicillium - Pleurotus ECHS1 - Aspergillus α-D-Man-(1->2)-α-D-Man-albicans: PC20G07670 D-glycerate phosphate biosynthesis I (via mevalonate) chrysogenum: (acyl-carrier- carrier-protein) cholesta-8-enol 2-phospho- thaliana: PC22G24780 tubingensis: niger: PC13G10870 reductase RhlG Aspergillus - Saccharomyces biosynthesis desaturase: beta chain fas1p - -Synechocystis pombe [putative sequencing methanol N-formimino-glycine polyamine oxidase PAO - [+ 7 isozymes] succinate dehydrogenase PC21G15970 cerevisiae: icdA - Aspergillus Saccharomyces cerevisiae: PC22G03630 PC22G03630 chrysogenum: eryngii: - Rattus niger: chloride (1->2)-α-D-Man-(1->3) phosphoglycerate isomerase pyrG protein) synthase (S)-malate D-glycerate phosphoenolpyruvate 2-phospho- PC22G22930 [+ 2 isozymes] - Pseudomonas nidulans: fructose-1,6- cerevisiae: acetyl-CoA isopentenyl PC16G08330 Schizosaccharomyces sp: PC22G14150 error]: PC21G08670 4-ureido-5-imidazole carboxylate [+ 2 isozymes] Zea mays: PC12G08750 3,4-dihydroxyphenylacetate -Saccharomyces long chain PC22G20660 niger: PC20G03610 cerevisiae: PC12G10940 [+ 2 isozymes] [+ 2 isozymes] PC22G02230 PC16G02950 norvegicus: PC12G02790 channel 3 -[α-D-Man-(1->2)-α-D- kinase pgkA- manA - reductase T32M21.120 enolase D-glycerate 6-phospho- aeruginosa: PC21G17880 D-ribose 5- bisphosphate PC13G12020 precursor of acetyl-CoA C- diphosphate UMP adenylosuccinate IMP dehydrogenase 5,7,22,24(28)- 4α-hydroxymethyl-4β- pombe: PC21G10870 transaldolase Tal1 [+ 3 isozymes] cerevisiae: PC06G01810 polyphosphate PC20G04720 malonate [+ 9 isozymes] an aromatic PC22G21270 clcn3 - Mus Man-(1->3)-α-D-Man- Penicillium Candida farnesyl- fabG - Bacillus -Arabidopsis BAC82549- enolase alcohol oxidase 4-hydroxyphenylpyruvate 2-oxoglutarate 2-dehydro- indole-3-glycolate PC22G03680 indole-3-acetate phosphate D-mannose acetyltransferase - Rattus synthase ade2p - IMH3 -Candida ergostatetraenol 4α-hydroxymethyl- methyl-5α-cholesta- pyruvate -Saccharomyces a polysaccharide semialdehyde trans-3'- aldehyde trans-2,3- chloride musculus chloride (1->6)]-β-D-Man-(1->4)- chrysogenum: pgkA fructose-1,6- albicans: pyrophosphate salvage pathways of guanine, xanthine, and their nucleosides subtilis: thaliana: fatty-acyl-CoA synthase Penicillium BAC82549- aox-Penicillium AMP caffeoyl-CoA H + N 1 -acetylspermidine 3-aminopropanal ferulate fumarate lipoamide D-gluconate [+ 5 isozymes] 6-phosphate norvegicus: PC22G00420 Schizosaccharomyces albicans: PC18G05320 5α-cholesta- 8,24-dien-3β-ol kinase pkiA cerevisiae: PC21G16950 diphosphate 1,4-α-D- a cis-delta11-3- hydroxycotinine stearoyl-CoA [putative β-D-GlcNAc-(1->4)-α-D- bisphosphatase PC13G08170 synthase FPPS PC16G12960 PC12G06970 C-24 sterol beta chain fas1p - chrysogenum: Penicillium chrysogenum: D-galacturonate cytosolic acetyl-CoA pombe: PC06G01770 8-en-3β-ol -Aspergillus galacturonide hydroxyC30:1- sequencing GlcNAc-diphosphodolichol 1,3-diphosphateglycerate fbpA - Aspergillus hypothetical - Gibberella IMP dehydrogenase [+ 5 isozymes] reductase: Schizosaccharomyces PC14G01740 chrysogenum: PC12G09950 gly 5-formimidoyltetrahydrofolate mannose-6- C-acetyltransferase UDP niger: [acp] error] oryzae: phosphomannomutase fujikuroi: IMH3 -Candida xanthosine guanine a (3R)-3- a 3-oxohexadecanoyl-[acp] PC22G11560 pombe: PC14G00740 PC14G01740 4-amino-5-imidazole carboxylate ammonia phosphate homolog - Erg10 - Saccharomyces 4α-formyl-4β- phosphoenolpyruvate PC18G06000 D-fructose-6-phosphate dihydroxyacetone phosphate membrane glyceraldehyde- PC22G05750 PC21G15240 nucleoside- adenylo-succinate albicans: PC13G07630 hydroxytetradecanoyl- fructose-1,6-bisphosphate hydrogen isomerase Pmi40 Schizosaccharomyces cerevisiae: PC22G10140 ergosterol 4α-formyl- methyl-5α-cholesta- phosphoenolpyruvate formaldehyde a long-linear protein 3-phosphate D-fructose- [+ 2 isozymes] diphosphate [acp] 3-oxoacyl-(acyl- aldolase - Thermus peroxide α-D-glucose a long-linear α-D-glucan (R)-6-hydroxynicotine L-sorbopyranose sucrose a [ribulose-1,5- an alcohol a ferricytochrome β-D-galactose a cis-delta13-3- indole-3-glyoxal a phosphate (2E,6E)-farnesyl α-D-Man-a-(1->2)-α-D- - Saccharomyces pombe: PC20G04410 acetoacetyl-CoA geranyl 5α-cholesta- 8,24-dien-3β-ol pyruvate pyruvate fructose-1,6-bisphosphatase ferulate D-threo-isocitrate 4-hydroxybutyrate ethylphosphate (S)-lactate α-D-glucan ATP involved dehydrogenase 6-phosphate kinase NDK-1 adenylosuccinate 3-hydroxyacyl- carrier-protein) aquaticus: PC20G09750 bisphosphate- b oxo-C32:1-[acp] monoester diphosphate α cerevisiae: diphosphate 8-en-3β-ol kinase pkiA pyruvate fbpA - Aspergillus triose-phosphate- catalase kat - 6-hydroxy-d-nicotine FAD dependent L- aldehydereductase precursor of 4-hydroxybutyrate 5 UDP-glucose 4- aldehyde L-lactate 2- extracellular adenylate in arsenite Man-(1->2)- -D-Man- gpdA - phosphomannomutase - Neurospora lyase ADSL - Homo guanine [acp] reductase fabG - 5,10-methenyltetrahydrofolate carboxylase]-lysine cytochrome-b5 extracellular acid NADPH- vacuolar alkaline trichodiene arsenite arsenite α glucose-6- PC13G12020 3-hydroxy-3-methylglutaryl- xanthosine-5-phosphate fatty acid activation wax esters biosynthesis II -Aspergillus kinase pkiA oryzae: PC22G05750 fructose-bisphosphate isomerase tpiA from patent Methanosarcina 4-aminoimidazole acetylphosphate oxidase 6-HDNO - sorbose dehydrogenase hypothetical protein ALR -Rattus norvegicus mitochondrial dehydrogenase epimerase Gal10 dehydrogenase monooxygenase alpha-amylase cyclase MAC1 transport (1->3)-[ -D-Man-(1->2) Aspergillus niger: Sec53 - Saccharomyces crassa: sapiens: PC20G14240 deaminase dehydrase: Bacillus subtilis: 4-alpha-glucanotransferase exo-inulinase inu1 reductase Mcr1 - phosphatase dependent phosphatase synthase Tri5 α α phosphate CoA synthase Erg13 niger: -Aspergillus formate aldolase Fba1 - WO8704464-A -Aspergillus barkeri [truncated methenyltetrahydrofolate 4-coumarate-CoA ligase Arthrobacter oxidans: SDH - Gluconobacter SPBC1709.13c - [putative sequencing isocitrate - Alcaligenes - Saccharomyces ALDH3 - Rattus LA2M - amyA/amyB -Magnaporthe like protein - -D-Man-(1->3)-[ -D- PC21G14560 D-mannose cerevisiae: PC14G01430 PC21G15880 like protein PC14G00080 PC16G12960 4α-carboxy-4β- acetate kinase like / amylo-1,6-glucosidase -Aspergillus niger: Saccharomyces PhoA-Penicillium beta-ketoacyl Pho8 - -Gibberella α isomerase Pgi1 - -Saccharomyces AMP a 1,2-diacyl- PC18G06000 niger: oxidation Saccharomyces ORF][putative cyclohydrolase: 4CL - Arabidopsis oxydans: PC13G08640 Schizosaccharomyces cerevisiae: - Aspergillus An18g03550 - Man-(1->6)]- -D-Man- 6-phosphate α GMP synthase An14g01140 4α-carboxy- methyl-5α-cholesta- a fatty acid arachidoyl-CoA niger: PC21G03400 Gdb1 -Saccharomyces PC22G24870 PC21G14720 error]: PC22G09510 dehydrogenase eutrophus: cerevisiae: chrysogenum: reductase RhlG norvegicus: Saccharomyces zeae: Mycobacterium grisea: dihydroxyacetone D-glyceraldehyde- Saccharomyces -D-mannose cerevisiae: PC18G01450 UTP a (2E)-tetradec- [+ 5 isozymes] sn-glycerol PC18G06000 to CO cerevisiae: PC18G01220 sequencing error]: protein An02g06420 PC20G03600 thaliana: PC22G24780 a [ribulose-1,5-pombe: PC22G06730 PC20G08410 niger: Aspergillus niger (1->6)]-β-D-Man-(1->4)- (glutamine-hydrolyzing) α β 2 [+ 6 isozymes] FAD dependent L- [+ 5 isozymes] icdA - Aspergillus PC13G01680 PC21G04770 PC22G03630 smegmati: PC12G11480 membrane phosphate 3-phosphate cerevisiae: pgi hypothetical 1-phosphate - Aspergillus 2-enoyl-[acp] 5 -cholesta- 8,24-dien-3 -ol acyl-CoA diacylglycerol pyruvate - Aspergillus niger: cerevisiae: PC22G22120 [+ 4 isozymes] bisphosphate- PC12G14860 - Pseudomonas cerevisiae: PC21G14700 β-D-GlcNAc-(1->4)-α-D- 3-hydroxy-3-methylglutaryl- Gua1 - Saccharomyces a (3R)-3- β PC23G00900 [+ 2 isozymes] niger: PC20G03610 succinate [+ 2 isozymes] PC22G24130 PC22G12340 protein phosphomannomutase hexaprenyl diphosphate CTP synthase niger: 8-en-3 -ol synthase acyltransferase formate 4-imidazolone PC18G00650 10-formyl-tetrahydrofolate 6-hydroxypseudooxynicotine sorbose dehydrogenase carboxylase]-N6- an aldehyde [+ 6 isozymes] [+ 5 isozymes] aeruginosa: [+ 2 isozymes] PC18G04190 [+ 5 isozymes] cyclic-AMP GlcNAc-diphosphodolicholmannosyltransferase β-D-glucose- GTP:alpha-D- CoA synthase Erg13 cerevisiae: PC12G16160 enoyl-[acyl- hydroxyhexadecanoyl-[acp] a medium- pyruvate D-glyceraldehyde-3-phosphate [+ 6 isozymes] semialdehyde α indole-3- [+ 6 isozymes] involved homolog - biosynthesis Ura7 - PC16G11230 like protein DAGAT - acetate- SDH - Gluconobacter methyl-L-lysine oxalosuccinate a ferrocytochrome ethanol -D-galactose PC22G03680 an alcohol trichodiene acetate 1 PMT1 - Candida fructose-1,6- 6-phosphate mannose-1-phosphate -Saccharomyces carrier-protein] chain ester a short glucan α β glyoxylate in arsenite Arabidopsis inducible acetate + oxydans: PC06G01600 -D-glucose -D-fructofuranose b a short glucan Schizosaccharomyces Saccharomyces 3-hydroxyacyl- An18g03800 O AMP feruloyl-CoA H 5 [+ 5 isozymes] arsenite arsenite albicans: PC12G05130 bisphosphate guanylyltransferase cerevisiae: PC12G01730 guanine glyceraldehyde-3- 2 formate- diphosphate a cis-delta13-3- pombe: PC20G04410 (2E,6E)-farnesyl cerevisiae: GMP reductase: [acp] dehydrase: 3-keto-4- thaliana: gene aciA - transport aldolase - like protein deaminase 5α-cholesta- - Aspergillus fructose-1,6-bisphosphate phosphate dehydrogenase tetrahydrofolate 5-dehydro-D-fructose hydroxyC32:1- mannosyltransferase diphosphate PC20G12420 PC14G00080 PC14G00080 methylzymosterol PC13G01800 Aspergillus like protein Thermus phosphomannomutase An11g02380 - (S)-3-hydroxy-3-methylglutaryl-CoA trans- like protein 8-en-3-one niger: gpdA - Aspergillus ligase: PC20G03600 [acp] 1 PMT1 - Candida enoyl nidulans: An18g03550 - α-D-Man-(1->2)-α-D-Man- aquaticus: Sec53 - Saccharomyces Aspergillus niger: pentaprenyltranstransferase CTP synthase An14g01140 PC13G01890 diacylglycerol niger: PC21G14560 N-formimino-glycine albicans: PC20G07670 hydroxymethylglutaryl- reductase of a (2E)-hexadec-2-enoyl-[acp] PC12G04310 Aspergillusmembrane niger (1->2)-α-D-Man-(1->3)-[α- PC20G09750 cerevisiae: PC14G01430 PC12G09190 Coq1 - Saccharomyces Ura7 - - Aspergillus acyltransferase long-chain- CO 54 a long-linear protein α α coenzyme A all-trans- cerevisiae: PC20G07830 the lovastatin 2 formate a uridine a DNA a 5'-dephospho- α D-Man-(1->2)- -D-Man- fructose- -D-mannose GDP-α-D- Saccharomyces niger: α fatty-acid--CoA DAGAT - 1,3-diphosphateglycerate a ribonucleotide a ribonucleotide cis-dienelactone dimethylallyl thiamin coumaraldehyde D-glyceraldehyde D-Iditol L-iditol a cis-delta17-3- cyclohexanone methanol α -maltose formamide α α reductase hmg1p - hexaprenyl biosynthesis fatty-acyl-CoA synthase 4- -methylzymosterol an acetylated histone trp a tRNA in tRNA cyclobutadipyrimidine [DNA] -D-glucan involved (1->3)-[ -D-Man-(1->2)- - bisphosphate 1-phosphate mannose cerevisiae: PC14G00380 zymostenol ligase Faa2 - Arabidopsis diphosphate thiamin aldehyde mannitol-1-phosphate sorbitol oxo-C36:1-[acp] glycogen alpha-1-6- α UDP-N-acetyl-D- Schizosaccharomyces diphosphate lovC - beta chain fas1p - phosphoglycerate acetate-inducible hypothetical N2,N2- cinnamyl-alcohol the tRNA(m5U54) DNA NADPH- lactone-specific polynucleotide methanol formamidase in arsenite D-Man-(1->6)]- -D-Man- aldolase Fba1 - PC13G07130 Saccharomyces thaliana: pyrophosphokinase tnr3p dehydrogenase 5-dehydrogenase dehydrogenase phosphorylase glucosidase arsenite arsenite β glucosamine biosynthesis II GTP:alpha-D- pombe: PC18G05230 Aspergillus Schizosaccharomyces kinase pgkA-Penicillium gene aciA - carboxymethylenbutenolide dimethylguanosine tRNA dehydrogenase methyltransferase photolyase dependent esterase estf1 - kinase-3- dehydrogenase fmdS - transport (1->6)]- -D-Man-(1->4)- Saccharomyces cerevisiae: PC13G04400 5-formimidoyltetrahydrofolate tRNA ligase Trl1 - Schizosaccharomyces aldA - Aspergillus mtlD - Streptococcus SDH - Rattus Gph1 - glcA - β α mannose-1-phosphate CTP terreus: pombe: PC14G00740 a triacyl-sn Aspergillus nidulans: histone deacetylase A hydrolase YDL086w dimethylallyltryptophan methyltransferase trm1p CAD1 - Eucalyptus Trm2 - phr1 - beta-ketoacyl Pseudomonas phosphatase Mdh - Bacillus Aspergillus like protein -D-GlcNAc-(1->4)- -D- 3-hydroxy-3-methylglutaryl α PC12G05520 chrysogenum: pgkA -Saccharomyces pombe: PC21G06070 mutans: PC22G20800 norvegicus: Saccharomyces cerevisiae: D-fructose-6-phosphate guanylyltransferase xanthine PC14G00090 fatty-acyl-CoA synthase 4 -hydroxymethyl- a long-chain -glycerol PC12G04310 Hda1 - Saccharomyces - Saccharomyces synthase dmaW - - Schizosaccharomyces gunnii: PC22G20490 niger: PC06G00180 Saccharomyces Trichoderma reductase RhlG fluorescens: PNKP - Homo methanolicus: Aspergillus nidulans: An18g03550 - GlcNAc-diphosphodolichol PC18G01220 coenzyme A reductase nucleoside- deoxyguanosine GMP guanosine oleate biosynthesis 5α-cholesta- cerevisiae: PC16G06530 thiamine PC21G23190 cerevisiae: parasiticus: glutamine-fructose-6- like protein beta chain fas1p - acyl-CoA 3-phospho-D-glycerate cerevisiae: PC21G14570 cerevisiae: PC22G11550 Claviceps purpurea: 2 pombe: PC14G00720 [+ 2 isozymes] [+ 10 isozymes] [+ 2 isozymes] cerevisiae: harzianum: - Pseudomonas PC22G16830 sapiens: PC12G10580 PC20G04820 Aspergilluslysosomal niger HmgA -Sulfolobus diphosphate lathosterol β CO an N - phosphate transaminase An11g02380 - trehalose biosynthesis I II (animals) 8,24-dien-3 -ol 2 diphosphate PC21G06420 PC22G22550 [+ 4 isozymes] PC14G01820 PC13G11660 PC22G07880 solfataricus: PC16G05060 a myristoyl-[acp] Schizosaccharomyces 2-maleylacetate PC21G15430 methylguanine coumaryl-alcohol D-glycerate D-sorbose a 5- aeruginosa: [+ 9 isozymes] [+ 12 isozymes] α formate cystine fructose-1,6- Aspergillus niger: kinase NDK-1 two adjacent pyrimidine a 5'-phospho- -D-glucose Gfa1 -Saccharomyces pombe: PC21G10870 5,10-methenyltetrahydrofolate a ribonucleotide in tRNA 54 L-sorbopyranose PC22G03680 ε-caprolactone formaldehyde [+ 8 isozymes] transporter bisphosphate α-D-glucose - Neurospora stearoyl-CoA methyluridine nucleosides in DNA [DNA] 1-phosphate L-cystine L-cystine α-D-Glc-(1->3)-α-D-Man- cerevisiae: PC14G01120 PC12G09190 (R)-mevalonate hypothetical 3- 6 α-D-glucose cystinosin 6-phosphate UDP-D-glucose crassa: stearoyl-CoA desaturase N -acetyl-L-lysine a deacetylated histone 4-(3-methylbut-2- in tRNA a cis-delta17-3-[+ 5 isozymes] (1->2)-α-D-Man-(1->2)-α- fructose-1,6- D-glucosamine 6-phosphate GDP-α-D- xanthosine- oxoacyl-(acyl- a palmitoyl-[acp] α α CTNS - mevalonate kinase PC21G15880 ole1 - Ajellomyces7-dehydro- 4 -formyl-5 -cholesta- phosphatidylethanolamine biosynthesis I methenyltetrahydrofolate trifunctional C1- enyl)-L-tryptophan hydroxyC36:1- D-Man-(1->3)-[α-D-Man- bisphosphatase mannose 5-phosphate carrier-protein) β Homo sapiens glucosamine-phosphate Erg12 - Saccharomyces capsulatus: PC20G01400cholesterol 8,24-dien-3 -ol cyclohydrolase: tetrahydrofolate salvage pathways of adenine, hypoxanthine, and their nucleosides [acp] (1->2)-α-D-Man-(1->3) fbpA - Aspergillus trehalose-6- CDP synthase palmitoyl-[acyl- Polymeric Compound Degradation subunit of N-acetyltransferase cerevisiae: PC13G07140 PC20G03600 synthase Ade3 - -[α-D-Man-(1->2)-α-D- oryzae: phosphate T32M21.120 carrier-protein] stearoyl-CoA desaturase a CDP-diacylglycerol the vacuolar Gna1 - Saccharomyces synthase trehalose biosynthesis III ole1 - Ajellomyces phosphatidylglycerophosphate Saccharomyces Man-(1->6)]-α-D-Man- PC22G05750 -Arabidopsis hydrolase: glycogen degradation I AMP 2-carboxy-5-oxo- pyruvate D,L-malic a (1->4)- N 2 -succinyl- H + ATPase Vma6 - H + cerevisiae: PC22G23800 mevalonate-5-phosphate synthase Pgs1 - Saccharomyces cerevisiae: a 2'-deoxyribonucleotide (deoxynucleotides) a 3β-hydroxy-δ 5 -steroid dopamine gentisate a benzenediol cinnamyl alcohol sinapaldehyde leukotriene-A4 a [protein]-L-serine L-glutaminyl- a cis-delta21-3- D-mannitol nitrite (1->6)]-β-D-Man-(1->4)- subunit 1 tpsA PC14G00080 capsulatus: PC13G14370 4α-carboxy-5α- glycogen degradation III homogalacturonan degradation 10-formyl-tetrahydrofolate (m) 2,5-dihydrofuran- dehydrogenase α-D-glucan D-fructose- thaliana: oxo-C40:1-[acp] hypoxanthine semialdehyde L-ornithine Saccharomyces β-D-GlcNAc-(1->4)-α-D- - Aspergillus α-D-glucose 6-phosphate α oleoyl-CoA cholesterol cholesta-8,24-dien-3β-ol cerevisiae: PC21G17630 PC20G03600 deoxyadenosine C-3 sterol dehydrogenase monoamine oxidase gentisate 1,2-dioxygenases 2-acetate precursor of laccase cinnamyl-alcohol cinnamyl-alcohol leukotriene-A4 serine racemase peptide E1α NADP-dependent aldehyde 1,4-alpha-glucan ornithine nitrate 6-phosphate N-acetyl-D-glucosamine 6-phosphate GDP- -D-glucose phosphomevalonate kinase PC12G06970 a glycogen 4-carboxymuconolactone glutaminyl-peptide pyruvate NADPH- cerevisiae GlcNAc-diphosphodolichol(glucosyl)-(mannosyl) - niger: palmitate a phosphatidylserine formate- adenine Erg26 - Saccharomyces maoN -Aspergillus xlnE - Pseudomonas -Neurospora crassa: dehydrogenase dehydrogenase hydrolase - - Mus musculus: xanthine mannitol dehydrogenase branching transaminase reductase NR1 9 glucose-6- Erg8 - Saccharomyces a glycogen methyl-esterified homogalacturonan a homogalacturonan decarboxylase like cyclotransferase dehydrogenase dependent (N-acetylglucosaminyl) phosphoacetylglucosamine PC22G02020 a 3-oxohexadecanoyl- thioesterase II hTE - Homo tetrahydrofolate phosphoribosyltransferase DNA ligase CaLIG4 cerevisiae: PC18G05820 niger: PC21G09410 alcaligenes: PC22G17660 PC22G08410 PC13G15800 dehydrogenase enzyme Glc3 - phosphate cerevisiae: PC21G10310 phosphatidylserine glycogen phosphorylase 5,10-methylenetetrahydrofolate protein An03g06020 CAD1 - Eucalyptus CAD1 - Eucalyptus Mus musculus: QPCT - Homo kinase isoform beta-ketoacyl dehydrogenase ALDH3 - Rattus otaA - -Zea mays: mitochondrial -diphosphodolichol mutase AGM1 - Candida trehalose-6-phosphate superpathway of D-myo-inositol Secondary Metabolite Biosynthesis [acp] sapiens: PC06G01040 glycogen phosphorylase ligase: PC20G03600 Apt1 - Saccharomyces -Candida albicans: MtDH - Agaricus Saccharomyces 2 [+ 4 isozymes] betacyanin biosynthesis myo-inositol isopenicillin N biosynthesis betaxanthin Gph1 - Saccharomyces C-3 sterol dehydrogenase [+ 3 isozymes] gentisate 1,2-dioxygenases [+ 3 isozymes] gunnii: PC22G20490 gunnii: PC22G20490 PC13G05400 serine racemase hxA - Aspergillus norvegicus: Aspergillus PC21G17200 H+-transporting isomerase Pgi1 - synthase subunit 1 (1,4,5)-trisphosphate metabolism mannitol camptothecin biosynthesis canavanine biosynthesis IAA biosynthesis V thioesterase II hTE -Homo α decarboxylase Psd2 pectin methylesterase polygalacturonase PC21G07170 - Aspergillus niger: (6z,8e,10e,14z)-(5s,12r) sapiens: 2 - Zea mays: reductase RhlG glucosyltransferase: albicans: PC13G02740 mevalonate-diphosphate 3-oxoacyl- 5 -cholesta- cerevisiae: PC13G11660 Gph1 - Saccharomyces cytoplasmic serine cerevisiae: PC21G11750 Erg26 - Saccharomyces xlnE - Pseudomonas [+ 2 isozymes] [+ 2 isozymes] - Mus musculus: nidulans: bisporus: PC22G03630 cerevisiae: nidulans: ATP synthase Saccharomyces tpsA - Aspergillus biosynthesis biosynthesis biosynthesis sapiens: PC22G07280 - Saccharomyces pme1 - Aspergillus pgaI -Aspergillus formate 3,4-dihydroxyphenylacetaldehyde PC12G01700 a benzosemiquinone -5,12-dihydroxyicosa- a peptide withPC13G08040 a phosphorylatedPC20G14220 - Pseudomonas nitrate α-D-Glc-(1->3)-α-D-Glc-PC21G19180 trehalose 6- D-myo-inositol 8,24-dien-3-one cerevisiae: PC13G11660 hydroxymethyltransferase [+ 3 isozymes] 3-oxoadipate- PC22G06330 PC15G01130 PC21G10060 PC18G03600 H + inhibitor H + cerevisiae: pgi N-acetyl-glucosamine-1-phosphate (via dopamine) indole-3- (acyl-carrier- cerevisiae: PC21G13070 deoxyadenosine cerevisiae: PC12G00300 alcaligenes: PC20G02510 cinnamaldehyde sinapyl-alcohol 6,8,10,14-tetraenoate PC06G01410 aeruginosa: [+ 2 isozymes] 2 (1->3)-α-D-Man-(1->2) niger: PC22G02020 diphosphomevalonate (1,4,5)- tyr D-fructose- D-glucose 6- 2-aminoadipate cys val an α-limit dextrin aculeatus: PC20G13370 niger: PC22G20290 N-terminal 5- pyruvate xanthine N -succinyl- phosphate trp L-homoserine acetonitrile protein) oleate an α-limit dextrin acetate-inducible Shm2 - Saccharomyces deaminase: a 3-oxo-δ 5 -steroid maleylpyruvate enol-lactone a [protein]-D-serine PC22G03680 D-fructose (S)-malate glycogen precursor Inh1 - -α-D-Man-(1->2)-α-D- β-D-glucose- decarboxylase Erg19 trisphosphate 6-phosphate phosphate nitrilase NIT1 [+ 3 isozymes] pectin methylesterase oxo-L-proline dehydrogenase L-glutamate 5- mannose-6- 1L-inositol 1- L-dopa reductase phosphatidylcholine chitinase precursor chit33 gene aciA - cerevisiae: PC13G05010 deoxyinosinePC13G10630 adenine Saccharomyces Man-(1->3)-[α-D-Man- 6-phosphate UDP-N-acetylglucosamine trehalose-6- - Saccharomyces aflatoxins B and G biosynthesis -Arabidopsis pme1 -Aspergillus a 2'-deoxyribonucleotide a cis-delta21-3-[+ 5 isozymes] semialdehyde trehalose 6-phosphate monophenol aromatic-L- 2 2 phosphate aromatic-L- fabG - Bacillus biosynthesis III a phosphatidylethanolamine 4-alpha-glucanotransferase - Trichoderma harzianum Aspergillus nidulans: cytoplasmic serine cerevisiae α pyrophosphorylase phosphate phosphate alpha-aminoadipyl- choline (1->2)- -D-Man-(1->3) cerevisiae: PC22G18320 Inositol-1,4,5- monooxygenase amino-acid synthase: amino-acid thaliana: subtilis: zymosterol / amylo-1,6-glucosidase aculeatus: PC15G01810 [putative sequencing PC12G04310 hydroxymethyltransferase hydroxyC40:1- α α CaUAP1 - Candida phosphatase isomerase L-canaline aflatoxins B and G biosynthesis cysteinyl-valine synthetase phosphoryl- 3-phosphoinositide biosynthesis permease Hnm1 -[ -D-Man-(1->2)- -D- trehalose-6-phosphate trisphosphate 5- melC2 - versicolorin B 1 1 PC22G01000 Gdb1 -Saccharomyces error]: PC21G15780 [acp] albicans: PC21G11950 like protein manA - loganin decarboxylase 1D-myoPC22G25050- decarboxylase PC16G12960 ethanolamine α Shm2 - Saccharomyces choline choline Man-(1->6)]-α-D-Man- phosphatase like protein isopentenyl diphosphate phosphatases D-myo-inositol Streptomyces pcbAB/acvA-Penicillium [+ 5 isozymes] cyclopropane a debranched -limit dextrin maltotetraose cerevisiae: PC22G22120 CO -Saccharomyces An11g10990 Candida DDC - Rattus inositol (3)- DDC - Rattus [+ 5 isozymes] a homogalacturonan methanol 2 cerevisiae: PC12G16020 (1->6)]-β-D-Man-(1->4)- UDP-α-N-acetyl-D-glucosamine An11g10990 - Aspergillus INPP5P - Mus (1,3,4,5)- ornithine chrysogenum [putative indole-3-acetate fatty acid (CFA) cerevisiae - Aspergillus isopentenyl-diphosphate antibioticus: albicans: norvegicus: monophosphate sterigmatocystin norvegicus: a (3R)-3- myo-inositol a homogalacturonan a homogalacturonan a monocarboxylic a (1->4)- β-D-GlcNAc-(1->4)-α-D- niger: PC20G08480 tetrakisphosphate carbamoyltransferase sequencing error]: pcbAB N-methylethanolamine biosynthesis a α-limit dextrin with short branches acetyl-CoA malonyl-CoA NADPH H + 10-hydroxygeranial vestitone 4-chlorosalicylate N-acetylputrescine a D-hexose indole-3-acetamide a cis-delta15-3- 5-hydroxy- musculus: PC22G18500 PC13G08170 PC14G00240 betaxanthin PC14G00240 hydroxyhexadecanoyl- 5α-cholesta- glycogen phosphorylase ser trans-dienelactone isovaleryl-CoA D-glycerate a D-amino acid a protein a protein glutaryl-CoA α-D-glucan nitrite GlcNAc-diphosphodolichol niger: Delta-isomerase Idi1 Inositol-1,4,5- argB - Aspergillus niger inositol O-methyltransferase phosphate CDPdiacylglycerol--inositol a [phospholipid] acid amide oxo-C34:1-[acp] L-tryptophan choline-transport PC22G15620 [+ 2 isozymes] biosynthesis dopamine [acp] 7,24-dien-3β-ol Gph1 - Saccharomyces glucan 1,3-beta- hypothetical alcohol dehydrogenase 2-hydroxyisoflavone isovaleryl-coenzyme salicylate hydroxylase monoamine oxidase hexokinase 1 hxk1p - amidase - hydroxypyruvate amidase - glutaryl-CoA 1,4-alpha-glucan nitrate PC20G08480 trehalose - Saccharomyces trisphosphate 5- mannose-6- [putative sequencing dihydrodemethylsterigmatocystin monophosphatase A omtA -Aspergillus N-[(5S)-5-amino-5-carboxypentanoyl]- 3-phosphatidyltransferase olefinic fatty acid hypoxanthine adenosine D-amino-acid NADPH- endopeptidase Clp protein kinase aromatic-L- mutant SCT1 inositol-1,4,5- secologanin tryptamine 3-hydroxyacyl- cerevisiae: PC13G11660 glucosidase: PC15G00210 adenosine deaminase carboxymethylenbutenolide C ADHC - Mycobacterium reductase - Arabidopsis A dehydrogenase like nahG - Pseudomonas maoN -Aspergillus Schizosaccharomyces Rhodococcus dehydrogenase Rhodococcus dehydrogenase branching reductase NR1 cerevisiae: PC21G21730 phosphatases dopaquinone phosphate error]: PC22G18390 qutG - Aspergillus parasiticus: PC16G00840 L-cysteinyl-D-valine -Rattus norvegicus: γ-linolenate cyclopropane- L-serine fatty acid synthase oxidase DAO - dependent chain like protein C pkcA - amino-acid choline supressor protein choline trehalose triphosphate 5- [acp] amylo-α-1,6-glucosidase: Aah1 - Saccharomyces hydrolase YDL086w smegmatis: PC16G00450 thaliana: PC22G19530 protein An07g04280 putida: PC22G17670 niger: PC21G09410 pombe: PC22G08480 sp: PC22G02210 HPRA - sp: GCHD - Homo enzyme Glc3 - -Zea mays: INPP5P - Mus isomerase Pmi40 dihydrodemethylsterigmatocystin nidulans: L-dopa PC16G14460 biosynthesis II (animals) fatty-acyl- dehydratase Cha1 alpha subunit Fas2 Fusarium solani: beta-ketoacyl An02g11960 - Aspergillus decarboxylase - Saccharomyces dimethylallyl diphosphate phosphatase 8-O-methylsterigmatocystin isopenicillin N synthase dehydrase: α maltotriose PC22G22120 cerevisiae: PC16G10530 - Saccharomyces [+ 5 isozymes] [+ 7 isozymes] - Aspergillus niger: [+ 12 isozymes] [+ 3 isozymes] [+ 2 isozymes] [+ 12 isozymes] Methylobacterium PC22G02210 sapiens: Saccharomyces PC21G17200 dolichyl musculus: - Saccharomyces O-ureidohomoserine O-methyltransferase: PC16G00840 PC14G00790 aromatic-L- CDP-N- phospholipid -D-glucose 1-phosphate - Saccharomyces - Saccharomyces PC22G00150 reductase RhlG Aspergillus niger: niger: DDC - Rattus cerevisiae Inp52 - ips/PcbC-Penicillium PC14G00080 a 1-phosphatidyl- [+ 2 isozymes] cerevisiae: PC22G11550 PC21G01100 D-hexose 6- extorquens: [+ 12 isozymes] PC20G07920 cerevisiae: diphosphooligosaccharide PC22G15620 cerevisiae: inositol amino-acid miraxanthin V methylethanolamine 7-dehydrodesmosterol linoleate like protein α cerevisiae: cerevisiae: PC14G00750 10-oxogeranial 2-hydroxyformononetin 4-chlorocatechol 4-acetamidobutanal indole-3-acetate [+ 6 isozymes] - Pseudomonas PC20G06920 PC21G07090 norvegicus: nitrate farnesyl-pyrophosphate Saccharomyces argininosuccinate chrysogenum: ips C30 botryococcene biosynthesis 1D-myo-inositol phosphoglucomutase: a debranched -limit dextrin phosphate PC21G03190 PC21G10060 PC13G12020 dihydrosterigmatocystin monophosphatase decarboxylase 8-O-methylsterigmatocystin a (2E)-hexadec- long-chain-fatty-acid- An13g00740 alpha-1-6-glucosidase PC16G03260 2-maleylacetate 3-methylcrotonyl-CoA a monocarboxylate a 2-oxo acid aeruginosa: Peptide a phosphoprotein crotonyl-CoA PC14G00240 lysosomal synthase FPPS - Gibberella cerevisiae: inositol-1,4,5- D-mannose strictosidine synthase Arg1 - PC18G01390 starch leucodopachrome qutG - Aspergillus DDC - Rattus monooxygenase: isopenicillin N 2-enoyl-[acp] -CoA ligase Faa2 - Aspergillus glcA - Aspergillus L-serine hydroxypyruvate PC22G03680 serotonin cystine fujikuroi: PC21G15240 PC20G09000 triphosphate 5- 6-phosphate Saccharomyces O-methyltransferase (2E,6E)-farnesyl 1-phosphatidylinositol serine/threonine- phosphoglucomutase: glucoamylase III Wsc2 glycogen phosphorylase nidulans: norvegicus: PC20G06670 - Saccharomyces niger: parasiticus: PC22G07880 dehydratase Cha1 a long-chain fatty acid [+ 5 isozymes] transporter [+ 2 isozymes] phosphatase cerevisiae: PC12G11190 A omtA -Aspergillus diphosphate enoyl-[acyl- 4-kinase Stt4 - protein PC20G04410 -Saccharomyces Gph1 - Saccharomyces xanthine inosine-5'-phosphate inosine a cis-delta15-3- PC13G08390 PC14G00240 aflatoxin G a phosphatidyl-N- cerevisiae: PC12G05520 a [phospholipid]PC21G04500 [+ 8 isozymes] - Saccharomyces cystinosin D-myo- Inp52 - parasiticus: PC16G00840 8-O-methylsterigmatocystin 1 carrier-protein] Saccharomyces kinase Tor1 - desmosterol cerevisiae: PC20G02620 cerevisiae: PC13G11660 dehydrogenase hydroxyC34:1- dopamine penicillin K methylethanolamine fatty acid containing α CTNS - geranyl diphosphate inositol (1,4)- Saccharomyces canavaninosuccinate monooxygenase: reductase: cerevisiae: Saccharomyces acyl-CoA synthase like -D-glucose 6-phosphate cerevisiae: hxA - Aspergillus [acp] L-cystine L-cystine myo-inositol biosynthesis dehydrosqualene phosphatidyl-N- cyclopropane [+ 8 isozymes] Homo bisphosphate cerevisiae: mannitol-1- strictosamide dihydro-O-methylsterigmatocystin PC20G14090 PC14G00080 PC20G09090 cerevisiae; protein An18g03800 α-D-glucose maltose PC13G07300 nidulans: PC22G06330 farnesyl diphosphate cyclo-dopa 5- argininosuccinate synthase: methylethanolamine α-D-glucose 1-phosphate sapiens PC20G09000 betanidin phosphate Gene-ID: Tor: - Aspergillus niger: synthase: PC20G10860 O-glucoside lyase ASAL - Candida isopenicillin N C30 PC21G13930 enoyl N-methyltransferase β-D-glucose pyruvate UDP-D-galactose a 2-(2-hydroxyacyl) uridine [myelin basic 3-hydroxypropanoyl- [putative D-myo-inositol a 1-phosphatidyl- PC22G20500 PC13G01890 4-alpha-glucanotransferase monodehydroascorbate vestitone cholesterol 5-chlorosalicylate formamide a phenol sulfate squalene a cis-2-enoyl-CoA Rh a ribonucleoside 1,2-propanediol glutaryl-CoA (2E,6E)-farnesyl D-arabitol farnesyl diphosphate albicans: PC20G06010 dihydro-O- aflatoxin B acyl-coenzyme botryococcene reductase of Opi3 - Saccharomyces 1D-myo-inositol linoleoyl-CoA / amylo-1,6-glucosidase phosphoglucomutase: sphingosine protein]-L-arginine CoA 5'-monophosphate 1-phosphate diphosphate sequencinglysosomal (1,3,4)- 1 cholesterol monodehydroascorbate D-arabinitol 2- 1D-myo- methylsterigmatocystin 3-methoxytyramine A:isopenicillin N presqualene the lovastatin cerevisiae: phosphatidylinositol PC18G01390 2-hydroxyisoflavone cholesterol 7alpha- salicylate hydroxylase cyanide arylsulfatase ars-1 - squalene mitochondrial protein Odp1 - chloride mitochondrial 5-nucleotidase U2 snRNA- glutaryl-CoA pentalenene error] synthase: PC21G15240 trisphosphate L-canavanine 4-phosphate Gdb1 -Saccharomyces reductase like protein uridine nucleosidase dehydrogenase cystine inositol (4)- camptothecin monooxygenase: acyltransferase diphosphate biosynthesis PC16G02100 3-kinase Vps34 - delta-6 desaturase -Mucor phosphoglucomutase: ceramide reductase - Arabidopsis monooxygenase nahG - Pseudomonas hydratase Cht - Neurospora crassa: monooxygenase - enoyl-CoA Saccharomyces peroxidase cpo enoyl-CoA 5NTD_DISOM specific dehydrogenase synthase - D-mannitol aflatoxin G cerevisiae: PC22G22120 An12g00600 - Aspergillus Urh1 - Saccharomyces ARDH - transporter (2E,6E)-farnesyl diphosphate monophosphate PC20G14090 2 (acyltransferase) lovC - Saccharomyces rouxii: PC21G06390 PC20G04410 UDPgalactosyltransferase thaliana: PC22G19530 CYP7 - Oryctolagus putida: PC22G17670 Gloeocercospora PC22G24250 Rattus norvegicus: hydratase cerevisiae: -Leptoxyphium hydratase - Discopyge protein A - GCHD - Homo Streptomyces L-cystine L-cystine gomphrenin I betanin squalene a phosphatidyl-N- cerevisiae: PC18G02220 cystinosin AAT/PenDE- Aspergillus cerevisiae; Gene-ID: [+ 2 isozymes] β-D-glucose acetyl-CoA CGT - Homo sapiens: niger: PC21G12080 [+ 7 isozymes] cuniculus: PC21G22260 [+ 12 isozymes] sorghi: PC18G02620 [+ 5 isozymes] PC22G15550 ECHS1 - Rattus PC13G02720 fumago: ECHS1 ommata: Homo sapiens: sapiens: sp: Pichia stipitis: synthase: dimethylethanolamine α-D-glucose 6-phosphate xanthine L-ascorbate- (S)-2,3- [myelin basic PC22G01340 CTNS - squalene synthase ERG9 - Penicillium terreus: Vps34: PC21G00590 PC20G06700 2-hydroxyformononetin 7α-hydroxycholesterol 4-chlorocatechol hydrogen cyanide a phenol norvegicus: ω PC22G07770 - Rattus PC22G00320 PC21G11050 PC20G07920 PC20G10530 aflatoxin B PC21G13930 a 1-phosphatidyl- a 1-phosphatidyl- γ glucokinase glkA - protein]-N - Homo sapiens 2 betaxanthin PC14G00090 phosphatidyl-N- -linolenoyl-CoA 6-phosphate uracil epoxysqualene PC22G21270 an organochlorine norvegicus: hydroxyacetone [+ 2 isozymes] Candida utilis: PC21G13930 chrysogenum: AAT 1D-myo-inositol 1D-myo-inositol xanthine D-ribose methyl-arginine a ribonucleoside crotonyl-CoA pentalenene urea transport methylethanolamine a 1-phosphatidyl- Aspergillus niger: β UDP a 2,3,4-saturated (3R compound PC22G21270 phosphate myo-inositol penicillin K squalene 3,4-bisphosphate 4,5-bisphosphate dehydrogenase a 1-( -D-galactosyl)-2-(2- D-ribulose protein Dur3 - a palmitoyl-[acp] N-methyltransferase 1D-myo-inositol PC22G23550 )-3-hydroxyacyl-CoA urea urea all-trans-geranyl-geranyl diphosphate hxA - Aspergillus hydroxyacyl)sphingosine acrylyl-CoA Saccharomyces Opi3 - Saccharomyces 3-phosphate acetylphosphate β-D-glucose-6-phosphate nidulans: PC22G06330 cerevisiae palmitoyl-[acyl- cerevisiae: PC16G02100 1-phosphatidyl- acetate kinase like urate carrier-protein] a 2'- a long-linear a partially 1D-myo- Amine and Polyamine Degradation protein An02g06420 + α β β 3-oxoadipate- uridine urea transport hydrolase: 1-phosphatidyl- malonyl-CoA 4-coumaroyl-CoA H monodehydroascorbate scytalone oleate 2,3-dihydroxybenzoate -D-glucose a 5'-phosphopolynucleotide a -D-galactoside an aldehyde -D-fructofuranose α vanillyl alcohol acrylamide a nitrile a phosphatidylcholine inositol 3,4,5- - Aspergillus niger: deoxyribonucleoside -D-glucan enol-lactone acetylated chitosan uridine protein Dur3 - PC14G00080 1D-myo-inositol monodehydroascorbate hexokinase 1 hxk1p - galactoside ketohexokinase endoglucanase chitosanase amidase - urea urea trisphosphate PC18G00650 Alcohol Degradation 1,3,6,8- cyclopropane-fatty-acyl- 5'-diphosphateribonucleotide 2,3-dihydroxybenzoic mRNA capping aldehyde 3-oxoadipate vanillyl-alcohol kinase Urk1 - nitrilase NIT1 Saccharomyces 3,5-bisphosphate spermine and spermidine degradation I choline-O-sulfate reductase like protein tetrahydroxynaphthalene phospholipid like protein acid decarboxylase Schizosaccharomyces enzyme MCE - acetyltransferase dehydrogenase khk - Homo A eglA - enol-lactone csnA - oxidase vaoA Rhodococcus -Arabidopsis palmitate allantoin degradation allantoin degradation urea degradation I chalcone synthase reductase suc22p - Saccharomyces cerevisiae degradation 4-aminobutyrate to ureidoglycolate acetate ethanol degradation An12g00600 - Aspergillus reductase arp2 -Aspergillus An13g00740 - Aspergillus dhbD - Aspergillus pombe: PC22G08480 Mus musculus: lacA - Escherichia aldA - Aspergillus sapiens: Aspergillus niger: hydrolase catD Aspergillus - Penicillium sp: PC22G02210 thaliana: to glyoxylate II (R,R)-butanediol Gchs2 - Gerbera niger: PC21G12080 Schizosaccharomyces coli: PC12G00220 PC22G22030 PC20G07340 oryzae: cerevisiae: spermine degradation II I (urea producing) IV (peroxisomal) ethanol degradation glycerol degradation IV fumigatus: PC21G16430 niger: PC21G04500 niger: PC20G01500 [+ 2 isozymes] PC18G02500 β niger: PC21G22810 - Pseudomonas simplicissimum: [+ 12 isozymes] PC22G01000 urea hybrida: PC22G09640 1,3,6,8- pombe: PC21G07530 α-D-glucose a generic a 6-acetyl- - fructose-1- PC22G09180 urea transport choline sulfate II (cytosol) degradation L-ascorbate- dihydrosterculate a ribonucleoside catechol [+ 10 isozymes] [+ 2 isozymes] sp: PC20G02000 PC12G07820 PC21G22360 acrylate [+ 5 isozymes] S-allantoin S-allantoin urea amidolyase naphthalenetetrol 6-phosphate polynucleotide substrate D-galactoside phosphate a partially acetylated protein Dur3 - choline sulfatase 4-aminobutyrate ethanol glycerol (R,R)-2,3- 6-phosphate diphosphate an acid a short glucan [+ 3 isozymes] vanillin UMP a carboxylate urea urea allantoinase Dal1 betC -Sinorhizobium allantoinase Dal1 Dur1 - ethanol chitosan fragment Saccharomyces 4-aminobutyrate catalase kat - glycerol butanediol 3-oxoadipate -Saccharomyces meliloti: PC22G01020 -Saccharomyces Saccharomyces 2,3-butanediol naringenin chalcone cerevisiae transaminase Methanosarcina alcohol dehydrogenase kinase GK - cerevisiae: choline cerevisiae: cerevisiae: dehydrogenase N 1 -acetylspermine gatA - barkeri [truncated adh1p - Mus musculus: PC20G11190 PC20G11190 PC20G09590 ADH - receptor- Aspergillus ORF][putative Schizosaccharomyces PC22G13330 polyamine spermine allantoinase Dal1 choline allantoinase Dal1 urea-1-carboxylate Pseudomonas α-D-glucose dCMP activated nidulans: sequencing error]: pombe: PC12G13440 sn-glycerol- carboxyphosphonoenolpyruvate (-)-sophorol glycyl-peptide cholesterol 5,6-dihydrouracil protoporphyrinogen IX β-D-glucose pyridoxine (S)-dihydroorotate propionate maltose a primary alcohol myo-inositol nicotinamide D-gluconate scytalone oxidase PAO oxidase: -Saccharomyces dehydrogenase -Saccharomyces putida: 6-phosphate cation channel PC21G17880 allophanate PC23G00900 [+ 11 isozymes] 3-phosphate hexokinase 1 hxk1p - maltose O- gluconokinase dCMP a cation a cation -Zea mays: PC12G08750 cerevisiae: betA -Escherichia succinate cerevisiae: PC23G00940 carboxyphosphonoenolpyruvate 2-hydroxyisoflavone glycylpeptide N- sterol o-acyltransferase dihydropyrimidinase protoporphyrinogen pyridoxine 4- orotate reductase acetate kinase like alcohol oxidase 3-isopropylmalate amidase - glucose-6- scytalone like protein hydrolase: acetaldehyde Schizosaccharomyces acetyltransferase gntV - deaminase Dcd1 PC18G02250 PC12G16220 coli [truncated semialdehyde PC12G16220 [+ 6 isozymes] glycerol-3- phosphonomutase reductase - Arabidopsis tetradecanoyltransferase Sat1 - Saccharomyces Pyd2 - Saccharomyces oxidase PPO - dehydrogenase PLR - pyrE -Aspergillus protein An02g06420 aox-Penicillium dehydrogenase Rhodococcus phosphate dehydratase An08g07550 - PC20G09590 [+ 14 isozymes] pombe: PC22G08480 maa - Escherichia Escherichia coli: -Saccharomyces allantoate ORF]: PC22G09460 allantoate acetaldehyde aldehyde dehydrogenase phosphate bcpA -Streptomyces thaliana: PC22G19530 Nmt - Ajellomyces cerevisiae: PC13G05460 kluyveri: PC22G20690 Mus musculus: Schizosaccharomyces nidulans: - Aspergillus niger: chrysogenum: leu2B - sp: PC22G02210 isomerase Pgi1 - -Pyricularia Aspergillus niger polyamine succinate- (R)-acetoin coli: PC22G16580 PC22G05190 cerevisiae: aldA - Aspergillus dehydrogenase hygroscopicus: PC22G24830 [+ 7 isozymes] capsulatus: PC13G07650 PC22G13300 [+ 2 isozymes] pombe: PC16G04830 PC22G21410 PC18G00650 PC12G09950 Aspergillus niger: [+ 12 isozymes] Saccharomyces oryzae: carboxylic oxidase PAO choline semialdehyde ammonia aldehyde N-tetradecanoylglycyl- a cholesterol ester 3-ureidopropionate β-D-glucose- 6-phospho- PC21G11370 niger: PC06G00180 like protein [+ 2 isozymes] 2'-hydroxypseudobaptigenin protoporphyrin IX pyridoxal orotate propionyl-P acetylmaltose an aldehyde PC22G00840 nicotinate cerevisiae: pgi PC16G10760 acid transport -Zea mays: dehydrogenase like dehydrogenase dehydrogenase peptide 6-phosphate D-fructose- D-gluconate dUMP 1,3,8- superpathway of 4- [+ 10 isozymes] An08g00210 - phosphinopyruvate [+ 6 isozymes] a carboxylate protein Jen1 - a carboxylate PC12G08750 protein An16g05660 NAD(P)+ gabD - aldA - Aspergillus 6-phosphate naphthalenetriol aminobutyrate degradation N-acetylglucosamine Aspergillus niger: 2-keto-myo Saccharomyces S-ureidoglycine - Aspergillus niger: Escherichia coli: S-(-)- niger: PC06G00180 spermidine degradation I acetate PC16G01790 -inositol cerevisiae PC13G13730 PC13G07790 ureidoglycolate [+ 10 isozymes] 4-aminobutyrate N-acetyl-D- dihydroxyacetone [+ 6 isozymes] 4-aminobutyrate acetate--CoA ligase betaine aldehyde glucosamine acetate phosphate transaminase gatA - facA-Penicillium succinate 6-phosphate urea degradation II betaine-aldehyde Aspergillus nidulans: N-acetylglucosamine- chrysogenum: facA N 1 - S-(-)- acetate--CoA ligase 6-phosphate acetyl coenzyme A acetylspermidine ureidoglycolate dehydrogenase PC21G17880 facA-Penicillium deacetylase urea synthase - Tetrahymena hypothetical betB - Escherichia succinate semialdehyde chrysogenum: facA polyamine coli: PC22G10030 CaNAG2 - urease accessory pyriformis: PC13G05130 oxidase PAO ureidoglycolate succinate- succinate- Candida albicans: protein ureF - acetyl coenzyme -Zea mays: hydrolase glycine betaine semialdehyde semialdehyde D-glucosaminePC22G10010 Actinobacillus A synthase - acetyl-CoA PC18G02250 SPAC19G12.04 - dehydrogenase like dehydrogenase 6-phosphate pleuropneumoniae: Tetrahymena Schizosaccharomyces pyriformis: polyamine protein An14g01440 NAD(P)+ gabD - PC20G12050 pombe: PC20G09430 glucosamine- PC13G05130 oxidase PAO - Aspergillus niger: Escherichia coli: 6-phosphate [+ 2 isozymes] ammonia -Zea mays: glyoxylate PC12G14920 PC13G07790 deaminase: acetyl-CoA PC12G08750 [+ 7 isozymes] [+ 6 isozymes] PC22G10040 putrescine succinate D-fructose- purine 6-phosphate purine a nucleotide α a nucleotide β purine UDP- -N a nucleoside fumarate guanine a nucleotide -D- -acetyl-D- a nucleoside α-L- Fe(III)-PS enterobactin an β-D-glucose galactose sucrose UDP-D- a hexose a hexose a hexose a hexose a hexose a hexose a hexose a nucleoside a polyamine D-mannitol succinate acetyl-CoA a nucleotide guanine a nucleotide a sterol a monocarboxylate a monocarboxylate a monocarboxylate a monocarboxylate a monocarboxylate a monocarboxylate a monocarboxylate a monocarboxylate nitrate a carboxylate glucosamine myo-inositol cytosine a hexose a hexose a hexose a hexose a hexose a hexose a hexose a hexose a hexose a hexose a hexose a bile acid a bile acid a bile acid arabinopyranose oligopeptide L-tartrate β-D-glucose β-D-glucose D-gluconate 4-aminobutyrate 4-aminobutyrate 4-aminobutyrate allantoate maltose galactose uracil uracil uracil guanine guanine brefeldin guanine intracellular galactose- purine purine A-inhibited iron- siderophore- hepatic glucose mitochondrial nucleotide ARF guanine- sucrose UDP-N- hypothetical high affinity hexose high affinity high affinity high affinity high affinity high affinity concentrative membrane arabinose oligopeptide polyamine mannitol acetyl-coenzyme proton hypothetical hypothetical hypothetical hypothetical hypothetical hypothetical hypothetical hypothetical hypothetical nitrate permease carboxylic UDP-galactose transport myo-inositol uracil transport uracil transport uracil transport hexose hexose hexose hexose hexose hexose transporter hexose hexose hexose transporter hexose hexose bile acid bile acid bile acid nucleoside guanine phytosiderophore iron transporter tartrate transport transport glucose glucose gluconate transport- succinate- GABA GABA permease GABA allantoate exchange guanine nucleotide nucleotide guanine nucleotide transport maltose transport acetylglucosamine purine-cytosine hexose transporter hexose hexose hexose hexose hexose Na+-nucleoside protein involved transport transporter transport transporter A transporter symporter sterol transporter monocarboxylate monocarboxylate monocarboxylate monocarboxylate monocarboxylate monocarboxylate monocarboxylate monocarboxylate permease with broad acid transport protein SpUGT - transporter 2 itr2p - protein fur4p - protein fur4p - protein fur4p - transporter Hxt2 transporter Hxt2 transporter Hxt2 transporter Hxt2 transporter Hxt2 ght2p - transporter Hxt2 transporter Hxt2 ght2p - transporter Hxt2 transporter Hxt5 transporter Ybt1 transporter Ybt1 transporter Ybt1 permease nucleotide- transporter for enterobactin protein ttuB - protein permease Rgt2 - permease Rgt2 - inducing protein gti1p fumarate permease Uga4 - like protein permease Uga4 - permease Dal5 - factor eIF-2B exchange factor scd1p exchange exchange factor scd1p protein protein Mal31 - transporter permease Fcy2 - transporter Hxt1 Hxt13 - transporter Hxt1 transporter Hxt1 transporter Hxt1 transporter Hxt1 transporter Hxt1 cotransporter in nucleoside protein araE like protein protein Tpo1 - like protein like protein galP - YMR034c - permease Esbp6 permease Esbp6 permease Esbp6 permease Esbp6 permease Esbp6 permease Esbp6 permease Esbp6 permease Esbp6 crnA - specificity protein Jen1 - Schizosaccharomyces Schizosaccharomyces Schizosaccharomyces Schizosaccharomyces Schizosaccharomyces - Saccharomyces - Saccharomyces - Saccharomyces - Saccharomyces - Saccharomyces Schizosaccharomyces - Saccharomyces - Saccharomyces Schizosaccharomyces - Saccharomyces - Saccharomyces - Saccharomyces - Saccharomyces - Saccharomyces NUP - exchange like protein Enb1 - Agrobacterium like protein Saccharomyces Saccharomyces - Schizosaccharomyces transporter Sfc1 Saccharomyces An14g01850 - Saccharomyces Saccharomyces 34 kDa alpha - Schizosaccharomyces factor 2 Gea2 - - Schizosaccharomyces suc1 - Saccharomyces SLC35A3 - Saccharomyces - Saccharomyces Saccharomyces - Saccharomyces - Saccharomyces - Saccharomyces - Saccharomyces - Saccharomyces cNT1 - Rattus transport Fun26 - Escherichia An15g07460 - Saccharomyces An02g07610 - An02g13410 - Escherichia Saccharomyces - Saccharomyces - Saccharomyces - Saccharomyces - Saccharomyces - Saccharomyces - Saccharomyces - Saccharomyces - Saccharomyces Aspergillus uapC - Saccharomyces pombe pombe pombe pombe pombe cerevisiae cerevisiae cerevisiae cerevisiae cerevisiae pombe cerevisiae cerevisiae pombe cerevisiae cerevisiae cerevisiae cerevisiae cerevisiae Candida protein An08g06700 - Saccharomyces vitis An09g04680 - cerevisiae cerevisiae pombe - Saccharomyces cerevisiae Aspergillus niger cerevisiae cerevisiae subunit Gcn3 - pombe Saccharomyces pombe Plantago cerevisiae Homo sapiens cerevisiae cerevisiae cerevisiae cerevisiae cerevisiae cerevisiae cerevisiae cerevisiae norvegicus -Saccharomyces coli Aspergillus niger cerevisiae Aspergillus niger Aspergillus niger coli [truncated cerevisiae cerevisiae cerevisiae cerevisiae cerevisiae cerevisiae cerevisiae cerevisiae cerevisiae nidulans Aspergillus cerevisiae albicans 2 - Homo Aspergillus niger cerevisiae Aspergillus niger cerevisiae Saccharomyces cerevisiae major cerevisiae ORF] nidulans sapiens cerevisiae UDP-D- uracil uracil uracil a nucleotide a nucleotide UDP-α-N myo-inositol a hexose a hexose a hexose a hexose a hexose a hexose a hexose a hexose a hexose a hexose a hexose a bile acid a bile acid a bile acid α-L- an L-tartrate β-D-glucose β-D-glucose D-gluconate 4-aminobutyrate 4-aminobutyrate 4-aminobutyrate allantoate maltose galactose a hexose a hexose a hexose a hexose a hexose a hexose a hexose a nucleoside a polyamine D-mannitol acetyl-CoA guanine guanine a sterol a monocarboxylate a monocarboxylate a monocarboxylate a monocarboxylate a monocarboxylate a monocarboxylate a monocarboxylate a monocarboxylate nitrate a carboxylate -acetyl-D- cytosine arabinopyranose Fe(III)-PS enterobactin oligopeptide β-D-glucose fumarate a nucleotide β-D- sucrose a nucleoside succinate a nucleotide guanine glucosamine a nucleoside a nucleotide galactose guanine purine purine purine This diagram was automatically generated by SRI International Pathway Tools version 25.0, authors S. Paley and P.D. Karp.