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Table 2. Significant Table 2. Significant (Q < 0.05 and |d | > 0.5) transcripts from the meta-analysis Gene Chr Mb Gene Name Affy ProbeSet cDNA_IDs d HAP/LAP d HAP/LAP d d IS Average d Ztest P values Q-value Symbol ID (study #5) 1 2 STS B2m 2 122 beta-2 microglobulin 1452428_a_at AI848245 1.75334941 4 3.2 4 3.2316485 1.07398E-09 5.69E-08 Man2b1 8 84.4 mannosidase 2, alpha B1 1416340_a_at H4049B01 3.75722111 3.87309653 2.1 1.6 2.84852656 5.32443E-07 1.58E-05 1110032A03Rik 9 50.9 RIKEN cDNA 1110032A03 gene 1417211_a_at H4035E05 4 1.66015788 4 1.7 2.82772795 2.94266E-05 0.000527 NA 9 48.5 --- 1456111_at 3.43701477 1.85785922 4 2 2.8237185 9.97969E-08 3.48E-06 Scn4b 9 45.3 Sodium channel, type IV, beta 1434008_at AI844796 3.79536664 1.63774235 3.3 2.3 2.75319499 1.48057E-08 6.21E-07 polypeptide Gadd45gip1 8 84.1 RIKEN cDNA 2310040G17 gene 1417619_at 4 3.38875643 1.4 2 2.69163229 8.84279E-06 0.0001904 BC056474 15 12.1 Mus musculus cDNA clone 1424117_at H3030A06 3.95752801 2.42838452 1.9 2.2 2.62132809 1.3344E-08 5.66E-07 MGC:67360 IMAGE:6823629, complete cds NA 4 153 guanine nucleotide binding protein, 1454696_at -3.46081884 -4 -1.3 -1.6 -2.6026947 8.58458E-05 0.0012617 beta 1 Gnb1 4 153 guanine nucleotide binding protein, 1417432_a_at H3094D02 -3.13334396 -4 -1.6 -1.7 -2.5946297 1.04542E-05 0.0002202 beta 1 Gadd45gip1 8 84.1 RAD23a homolog (S. cerevisiae) 1448776_at -3.7283009 -3.72681213 -1.3 -1.5 -2.5736666 0.000116226 0.0016026 B2m 15 66.9 beta-2 microglobulin 1449289_a_at AI848245 1.51079782 3.65724851 2 3.1 2.56050009 2.1386E-07 6.96E-06 Mapre1 2 154 microtubule-associated protein, 1450740_a_at AI849267 2.31002436 2.81420448 2.6 2.4 2.54972036 0 0 RP/EB family, member 1 Armc1 18 24.3 RIKEN cDNA 2310016N05 gene 1415719_s_at 4 4 1.5 0.7 2.54950427 0.002761949 0.017684 Prdx2 8 84.3 peroxiredoxin 2 1430979_a_at H3009C12 4 2.79390641 2.4 0.8 2.51320487 0.000112295 0.0015624 1110021H02Rik 1 171 RIKEN cDNA 1110021H02 gene 1416327_at H3079G08 2.91930791 4 0.6 2.4 2.48694606 0.000415387 0.0044076 Orc6l 8 84.6 origin recognition complex, subunit 6- 1417037_at H3135E06 3.09437768 4 0.9 1.9 2.47269384 0.00025404 0.0030001 like (S. cerevisiae) NA 8 83.7 Mus musculus transcribed sequence 1420287_at 4 2.66124778 1.3 1.8 2.44305776 3.31978E-05 0.0005854 Dusp14 11 83.7 dual specificity phosphatase 14 1431422_a_at H3112D07 4 3.03362473 1.4 1.3 2.43616593 0.000197438 0.0024577 Kcna7 7 32.8 potassium voltage-gated channel, 1450490_at 457594 -3.37536937 -4 -2 -0.3 -2.4303841 0.002840155 0.0179825 shaker-related subfamily, member 7 Efhd2 4 140 DNA segment, Chr 4, Wayne State 1431339_a_at H3126D06 1.69294152 3.39558455 2 2.5 2.40656197 9.22815E-11 5.79E-09 University 27, expressed NA 9 119 acetyl-Coenzyme A acyltransferase 1 1416947_s_at 2.41067711 3.50612314 1.6 2 2.38553621 4.41131E-09 2.09E-07 Asb1 1 91.5 ankyrin repeat and SOCS box- 1434961_at H3145G12 4 3.00152901 1 1.4 2.35675158 0.000714083 0.0066821 containing protein 1 Mapre1 2 154 RIKEN cDNA 5530600P05 gene 1428820_at AI849267 4 0.78445525 2.1 2.4 2.32398015 0.000441515 0.0046324 NA 9 49.6 neural cell adhesion molecule 1 1426865_a_at -4 -1.65726627 -1.6 -2 -2.3234081 3.92648E-05 0.0006663 1500010G04Rik 6 49.2 RIKEN cDNA 1500010G04 gene 1442886_at AI848139 -2.54248701 -0.63613493 -4 -2.1 -2.3219341 0.000797143 0.0072038 Rbm28 6 29 Riken cDNA 2810480G15 gene 1452091_a_at H3014D12 2.5702744 2.64866208 1.6 2.4 2.31793069 0 0 BC021790 11 69.2 cDNA sequence BC021790 1423808_at AI854620 4 2.17048724 1.4 1.7 2.31567178 7.37886E-05 0.0011195 4933431N12Rik 8 82.5 RIKEN cDNA 4933431N12 gene 1431253_s_at 355775 3.05203561 2.56123676 1.7 2 2.31432424 6.90559E-14 6.76E-12 Rabl4 15 78.5 RIKEN cDNA 2600013G09 gene 1424648_at AI854043 1.99723831 3.12823698 2.8 1.3 2.29256305 3.20503E-08 1.25E-06 Psmb6 11 70.1 proteasome (prosome, macropain) 1448822_at 4 0.69395761 2.5 2 2.29118438 0.000786669 0.007142 subunit, beta type 6 Scara3 14 57.9 RIKEN cDNA C130058N24 gene 1427020_at AI853099 3.33202352 1.75366658 2.4 1.6 2.26487693 7.43311E-09 3.34E-07 Med8 4 117 RIKEN cDNA 2210021A15 gene 1431423_a_at 2.42548383 2.82585769 2.4 1.4 2.25983251 4.69402E-13 4.03E-11 Hmgn2 17 81.1 high mobility group nucleosomal 1433507_a_at AI836129 -4 -1.79114485 -1.4 -1.8 -2.2521929 0.000130383 0.0017586 binding domain 2 Prkce 17 84.7 protein kinase C, epsilon 1449956_at H4047H10 1.18463277 4 1.9 1.8 2.23699027 0.00024741 0.002933 Rpp25 9 57.7 expressed sequence AI851155 1448845_at 3.13033207 0.57942435 3.2 2 2.22032565 0.000276669 0.0031958 Dibd1 9 50.9 disrupted in bipolar disorder 1 1418844_at H3023E04 4 1.31081995 2.9 0.7 2.21945986 0.003220863 0.0196234 homolog (human) NA 4 154 --- 1441282_at -3.04107213 -4 -0.6 -1.2 -2.2154839 0.005019755 0.0263403 Kif1c 11 70.3 Mus musculus 18-day embryo whole 1424746_at H3119C08 3.20589676 1.41232421 2.5 1.8 2.21417547 2.79872E-08 1.10E-06 body cDNA, RIKEN full-length enriched library, clone:1110061F19 product:unknown EST, full insert sequence Prkcz 4 153 protein kinase C, zeta 1454902_at H3047A06 2.53362036 3.49158725 1.8 1 2.21187416 2.5415E-05 0.0004648 Igsf8 1 172 immunoglobulin superfamily, member 1460675_at 385141 1.87932513 2.23077099 2.3 2.4 2.21123966 0 0 8 Copa 1 172 coatomer protein complex subunit 1415706_at H3128B03 2.2164815 2.6575113 0.8 3.1 2.20873625 1.00952E-05 0.0002137 alpha Ccnd2 6 128 cyclin D2 1455956_x_at H3117B01 2.52075974 3.80294891 2.2 0.3 2.20541777 0.002253639 0.0153227 Gart 16 92.1 phosphoribosylglycinamide 1416283_at AI842717 2.8261905 4 1 1 2.20426287 0.002818707 0.0179096 formyltransferase Kai1 2 93.3 Mus musculus transcribed sequence 1449611_at H3139E03 -2.84378264 -4 -1.5 -0.4 -2.2025644 0.004616963 0.0248784 with strong similarity to protein pir:I49561 (M.musculus) I49561 C33/R2/IA4 - mouse C1qb 4 135 complement component 1, q 1417063_at AI854126 1.55711902 3.29775011 2.2 1.7 2.20061903 1.78238E-08 7.29E-07 subcomponent, beta polypeptide Lrp4 2 91.4 RIKEN cDNA 6430526J12 gene 1426288_at 354643 4 0.68353005 2.3 1.8 2.19197628 0.001459223 0.0112109 1500010G04Rik 6 49.2 RIKEN cDNA 1500010G04 gene 1455933_at AI848139 -3.0640167 -1.54465757 -2.6 -1.6 -2.189072 8.56563E-09 3.81E-07 Traf3ip1 1 91.4 TNF receptor-associated factor 3 1452887_at H3145F02 4 3.17225148 0.6 1 2.18142787 0.008742773 0.0378447 interacting protein 1 Phf17 3 41.4 --- 1438412_at AI848831 4 2.10618432 0.9 1.7 2.17196071 0.000925663 0.0080622 NA 19 60.3 peroxiredoxin 3 1416292_at 4 1.86879261 0.8 2 2.17011837 0.001109423 0.0091727 Atp1a2 1 172 ATPase, Na+/K+ transporting, alpha 1452308_a_at AI839740 1.99675921 2.417536 0.6 3.6 2.16425426 0.000564861 0.0056101 2 polypeptide Hyou1 9 44.5 calcium binding protein 140 1423290_at H4065C07 -1.78575442 -2.05449547 -2.8 -2 -2.1624729 0 0 1110014J01Rik 9 71.1 RIKEN cDNA 1110014J01 gene 1448141_at 2.23163498 4 1.7 0.8 2.16202189 0.00158492 0.0118854 2410005H09Rik 7 13.2 RIKEN cDNA 2410005H09 gene 1424490_at 3.03290733 3.72019741 1.7 0.1 2.15869324 0.006247435 0.0303666 Nek2 18 24.4 NIMA (never in mitosis gene a)- 1437579_at H3035F11 1.62981274 2.42819004 3.7 0.8 2.15718816 0.000453079 0.0047308 related expressed kinase 2 D8Ertd812e 8 84 DNA segment, Chr 8, ERATO Doi 1437314_a_at AI849027 3.33320036 3.22759747 0.3 1.7 2.14815675 0.002531388 0.0166462 812, expressed Pmm1 15 82.3 phosphomannomutase 1 1424167_a_at AI840132 4 1.99850645 1 1.5 2.13821562 0.001041724 0.0087456 Sec61a1 6 88.8 Sec61 alpha 1 subunit (S. cerevisiae) 1434986_a_at AI844883 3.3603257 2.78436365 0.7 1.7 2.13669846 0.000296875 0.0033804 Ctsb 14 55.1 cathepsin B 1417491_at AI851255 1.274696 2.28198295 2.5 2.5 2.13302958 2.04281E-13 1.88E-11 Rasl11b 5 72.9 RIKEN cDNA 1190017B18 gene 1423854_a_at AI848851 1.75646641 3.83715431 1.1 1.8 2.12689872 0.000316794 0.0035484 Ngef 1 87.4 neuronal guanine nucleotide 1448978_at 716546 2.52985772 2.95323664 1.6 1.4 2.12153873 1.0007E-08 4.38E-07 exchange factor 9130213B05Rik 5 90.3 RIKEN cDNA 9130213B05 gene 1424214_at H3052E08 2.35529729 3.56216359 1.2 1.3 2.11527274 0.000108975 0.0015245 Pdlim7 13 54.6 RIKEN cDNA 1110003B01 gene 1417959_at H3082E06 2.97350927 4 1.2 0.3 2.10917109 0.012387601 0.0473357 Dullard 11 69.6 Dullard homolog (Xenopus laevis) 1452100_at H3007C12 1.15668201 2.91383465 2 2.4 2.10824207 1.21041E-08 5.20E-07 Cct7 6 85.7 chaperonin subunit 7 (eta) 1415816_at H3026F07 2.12361132 4 1.1 1.2 2.10548131 0.001740657 0.0126844 Tcl1b1 12 99.9 T-cell leukemia/lymphoma 1B, 1 1448981_x_at H3086F09 -3.28836662 -2.60538019 -1.1 -1.4 -2.1039501 3.75174E-05 0.0006442 1110030H18Rik 5 111 RIKEN cDNA 1110030H18 gene 1452663_at AI851182 1.84349882 2.60246168 1.5 2.4 2.09369145 1.11022E-15 1.35E-13 Rad23a 8 84.1 RAD23a homolog (S.
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