Cough and Cold Therapeutic Class Review (TCR) June 1, 2020 No part of this publication may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopying, recording, digital scanning, or via any information storage or retrieval system without the express written consent of Magellan Rx Management. All requests for permission should be mailed to: Magellan Rx Management Attention: Legal Department 6950 Columbia Gateway Drive Columbia, Maryland 21046 The materials contained herein represent the opinions of the collective authors and editors and should not be construed to be the official representation of any professional organization or group, any state Pharmacy and Therapeutics committee, any state Medicaid Agency, or any other clinical committee. This material is not intended to be relied upon as medical advice for specific medical cases and nothing contained herein should be relied upon by any patient, medical professional or layperson seeking information about a specific course of treatment for a specific medical condition. All readers of this material are responsible for independently obtaining medical advice and guidance from their own physician and/or other medical professional in regard to the best course of treatment for their specific medical condition. This publication, inclusive of all forms contained herein, is intended to be educational in nature and is intended to be used for informational purposes only. Send comments and suggestions to [email protected].

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FDA-APPROVED INDICATIONS1 Cough and cold formulations are available for use in the treatment of the signs and symptoms of the common cold, sinusitis, allergies, and cough. They come in various combinations from simple cold formulations, narcotic cough and cold formulations, as well as non-narcotic cough and cold formulations. The cold formulations are available as prescription generics which are combined in one of the following manners with several of the available ingredients: antihistamine-only, antihistamine-decongestant, decongestant-expectorant, and expectorant-only. There are many narcotic cough and cold formulations available as prescription generics which are combined in one of the following manners with several of the available ingredients: antitussive-anticholinergic, antitussive-antihistamine-decongestant, antitussive-decongestant-expectorant, and antitussive-expectorant. Lastly, there are many non-narcotic cough and cold formulations that are available as prescription generics which are combined in one of the following manners with several of the available ingredients: antitussive-antihistamine, antitussive- antihistamine-decongestant, antitussive-antihistamine-decongestant-expectorant, antitussive- decongestant, antitussive-decongestant-expectorant, and antitussive-expectorant. Current products are listed in Appendix A. OVERVIEW The common cold is a viral illness that affects persons of all ages prompting frequent use of over-the- counter (OTC) and prescription medications and alternative remedies.2 Adults in the United States (US) experience 2 to 3 colds per year, and the incidence in children is even greater.3 At least 200 identified viruses are capable of causing the common cold. The viruses often implicated include rhinoviruses, coronaviruses, parainfluenza viruses, respiratory syncytial virus, adenoviruses, and enteroviruses. Although histologic effects on the nasal epithelium may vary, any of the viruses can cause vasodilation and hypersecretion, leading to the common cold syndrome, which includes nasal congestion, nasal discharge, postnasal drip, throat clearing, sneezing, and cough. Acute cough has been characterized as a cough lasting 3 weeks or less, sub-acute cough lasts 3 to 8 weeks, and chronic cough lasts over 8 weeks.4,5 Causes of acute cough include the common cold or other respiratory tract infection, and allergic rhinitis. Subacute cough remains after the initial cold or respiratory infection is over. Causes of chronic cough include asthma, chronic bronchitis, and chronic obstructive pulmonary disease (COPD). Cough may also be associated with factors such as gastroesophageal reflux disease (GERD), medication side effects, pulmonary embolism, smoking, and lung cancer; cough due to these conditions will not be addressed in this class review. Common cold, or upper respiratory tract infection, is the third most common reason for physician visits, with cough being a common presenting symptom.6 In 2017 American College of Chest Physicians (ACCP) updated their clinical practice guidelines on the cough. The ACCP suggests against use of OTC cough and cold medicines and nonsteroidal anti-inflammatory drugs (NSAIDs) in adults and pediatric patients until these products have demonstrated that they decrease cough severity or time to cough resolution. In pediatric patients (≤ 18 years of age), ACCP suggests use of honey in patients to relieve cough over diphenhydramine, or no treatment, but does not recommend honey over dextromethorphan. Notably, honey should not be used in infants less than 1 year of age and children less than 2 years of age should not be given dextromethorphan for cough. Codeine-containing medications should be avoided in pediatrics due to the potential for serious adverse effects.7

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There are a variety of prescription and OTC cough and cold combination products. The focus of this review will be on the prescription products with emphasis on the component ingredients. There are also numerous generic products available. PHARMACOLOGY Drug Type Mechanism of Action Examples Anticholinergics Competitively blocks the muscarinic receptors, primarily M2 and M3, homatropine, and causes the drying effect on mucus membranes. methscopolamine, scopolamine Antihistamines Competitively antagonize the effects of histamine on H1-receptors in brompheniramine, (first generation) the GI tract, uterus, large blood vessels, and bronchial smooth muscle; carbinoxamine, Blockade of H1-receptors also suppresses the formation of edema, chlorpheniramine, clemastine, flare, and pruritus that result from histaminic activity; H1-antagonists cyproheptadine, also possess anticholinergic properties in varying degrees dexbrompheniramine, dexchlorpheniramine, diphenhydramine, doxylamine, hydroxyzine, promethazine, pyrilamine, triprolidine Antitussives Directly act on receptors in the cough center of the medulla; These codeine, (opiate) agents may also have a drying effect on the respiratory tract and dihydrocodeine, increases the viscosity of bronchial secretions; Cough suppression can hydrocodone be achieved at lower doses than those required to produce analgesia; The most significant adverse effect associated with opiate agonist use is respiratory depression which results from a decreased sensitivity to carbon dioxide in the brainstem; Opiates cause generalized central nervous system (CNS) depression; Additive sedative effects are possible with other agents that can lead to CNS depression Antitussives Dextromethorphan is a non-competitive antagonist of N-methyl-D- carbetapentane, chlophedianol, (non-opiate) aspartate (NMDA) receptors in the brain and spinal cord; It acts on the dextromethorphan cough center in the medulla to raise the threshold for coughing by decreasing the excitability of the cough center; It is the d-isomer of levorphanol but has none of the analgesic, respiratory depressive, or sedative effects associated with opiate agonists Carbetapentane and chlophedianol appear to work directly on the cough center of the medulla, thereby suppressing the cough reflex; Carbetapentane has atropine-like and anesthetic actions, producing a drying effect of respiratory mucus secretion; In addition, it possesses mild bronchodilatory actions, and does not affect respiratory volume Decongestants Phenylephrine possesses both direct and indirect sympathomimetic phenylephrine, effects, primarily as a post-synaptic alpha-adrenergic agonist, pseudoephedrine* producing potent vasoconstriction; An indirect effect due to the release of norepinephrine plays a small role in the overall action of phenylephrine; Constriction of blood vessels leads to reduced blood flow to the nose, decreased amount of blood in the sinusoid vessels, and decreased mucosal edema, which relieves nasal congestion; Phenylephrine does not affect the beta receptors in the heart or lungs Pseudoephedrine is a sympathomimetic amine that causes the release of norepinephrine, leading to vasoconstriction and a decrease in nasal and sinus congestion Expectorants Loosens and thins sputum and bronchial secretions to ease guaifenesin expectoration * Many products containing pseudoephedrine have been reformulated due to increased regulatory restrictions on the sale and distribution of the drug, likely due to its notable use as a precursor in the illicit synthesis of methamphetamine.

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PHARMACOKINETICS Due to the various product formulations and varying component ingredients in the cough and cold products, the specific product information should be consulted to evaluate pharmacokinetics. CONTRAINDICATIONS/WARNINGS In January 2007, the Centers for Disease Control and Prevention (CDC) warned caregivers and healthcare providers of the risk for serious injury or fatal overdose from the administration of cough and cold products to children and infants less than 2 years of age.8 This warning followed an investigation of the deaths of 3 infants less than 6 months of age that were attributed to the inadvertent inappropriate use of these products. The symptoms preceding these deaths have not been clearly defined, and there is a lack of conclusive data describing the exact cause of death. The report estimated that 1,519 children less than 2 years of age were treated in emergency departments (EDs) during 2004 and 2005 for adverse events related to cough and cold medications. In October 2007, the Food and Drug Administration (FDA) Nonprescription Drug Advisory Committee and the Pediatric Advisory Committee recommended that nonprescription cough and cold products containing pseudoephedrine, dextromethorphan, chlorpheniramine, diphenhydramine, brompheniramine, phenylephrine, clemastine, or guaifenesin not be used in children less than 6 years of age.9 In January 2008, the FDA issued a Public Health Advisory recommending that OTC cough and cold products not be used in infants and children less than 2 years old.10,11,12 The FDA recommends that if parents and caregivers use cough and cold products in children older than 2 years, labels should be read carefully, caution should be used when administering multiple products, and only measuring devices specifically designed for use with medications should be used. While some combination cough/cold products containing these ingredients are available by prescription only and are not necessarily under scrutiny by the FDA, clinicians should thoroughly assess each patient’s use of similar products, both prescription and nonprescription, to avoid duplication of therapy and the potential for inadvertent overdose. In January 2008, a FDA panel recommended that nonprescription cold medicines should not be given to children under 2 years old due to the risk of serious and potentially life-threatening adverse reactions. Research has shown that these products offer little to no benefit in this patient population, and may increase the risk of poisoning.13 In October 2008, manufacturers of cough and cold products voluntarily modified their labels to increase the age recommended warnings for use in children and infants to less than 4 years of age versus the previous warning in children and infants less than 2 years of age, making this a more stringent warning than the FDA advisory.14,15 Manufacturers also introduced child-resistant packaging and new measuring devices for use with the products. Alternatives for this patient population include acetaminophen or ibuprofen which can be used to minimize pain and fever, and saline nasal sprays which can be used to clear nasal passages. A cool mist vaporizer is also an option for congestion.16 A retrospective review of OTC cough and cold medication ingestions reported to US poison centers between 2000 and 2010 revealed that unintentional ingestions of these medications decreased by 33.4% and therapeutic errors by 46%.17 Healthcare facility referrals declined for unintentional ingestions (28.9% in patients less than 2 years of age, 19.9% in ages 2 to 5 years, [p<0.0001]) and therapeutic errors (59.2% in children less than 2 years of age; p<0.0001). In addition, among children less than 2 years of age, ED visits related to cough and cold medication decreased from 4.1% of all adverse drug event ED visits before the 2007 manufacture’s voluntary market withdrawal of infant cough and cold medications to

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2.4% afterward. Similarly, among children aged 2 to 3 years, ED visits related to cough and cold medication adverse drug events decreased from 9.5% of all adverse drug event ED visits before the labeling revision announcement to 6.5% afterward.18 In 2015, the FDA announced they were investigating possible risks of using codeine-containing medications to treat cough and cold symptoms in patients less than 18 years old due to the risk of serious side effects, including slowed or difficult breathing.19 Due to the serious risks associated with the use of codeine-containing products in children, the FDA subsequently issued a drug safety communication regarding the use of codeine on April 20, 2017.20 Product labeling for all codeine-containing products was updated to add a contraindication alerting that codeine should not be used to treat pain or cough in children younger than 12 years. A warning was added to recommend against the use of codeine- containing products in adolescents between 12 and 18 years who are obese or have conditions such as obstructive sleep apnea or severe lung disease, which may increase the risk of serious breathing problems. Additionally, the warning regarding breastfeeding was strengthened to state that breastfeeding is not recommended with use of codeine-containing products due to the risk of serious adverse reactions in breastfed infants, which can include excess sleepiness, difficulty breastfeeding, or serious breathing problems that could result in death. In January 2018, the FDA issued an additional drug safety communication for prescription opioid cough and cold products limiting their use to adults (aged 18 years and older) due to the risks of these medicines outweighing their benefits in children younger than 18 years old.21 The FDA also required the addition of safety information about the risks of misuse, abuse, addiction, overdose, death, and slowed or difficult breathing to the Boxed Warnings for prescription cough and cold medicines containing codeine or hydrocodone. Some pyrilamine products may contain phenylalanine. These products should not be used in patients with phenylketonuria (PKU). DRUG INTERACTIONS22

Drug Type opiate)

-

(opiate)

Antitussives Antitussives

(non

Expectorants

Decongestants

Antihistamines

Anticholinergics

CNS depressants --  ------(e.g., alcohol, sedatives, anxiolytics, etc.) Monoamine oxidase inhibitors (MAOIs) --  ------Tricyclic antidepressants   ------Alpha blockers ------ -- Beta blockers ------ -- Centrally acting antihypertensives ------ -- Antidiabetic agents ------ -- Ototoxic medications   ------(e.g., aminoglycosides)

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Concurrent administration of methscopolamine nitrate with phosphodiesterase type 5 (PDE5) inhibitors (e.g., sildenafil, vardenafil) has been shown to potentiate hypotension due to the nitrate. Therefore, the concurrent use of these agents with products containing methscopolamine nitrate is not recommended. ADVERSE EFFECTS23,24

te)

Drug Type opiate)

-

(opia

Antitussives Antitussives Antitussives

(non

Expectorants

Decongestants

Antihistamines

Anticholinergics

Drowsiness       Xerostomia   -- --  -- Nausea  --     Tachycardia / Palpitations  ------ -- CNS depression      -- Respiratory depression  --   -- --  = Reported Adverse effects are reported above as a class effect due to the multiple ingredients contained in the products. Adverse effects have been taken from package inserts or other reliable databases and are not meant to be comparative or all inclusive. SPECIAL POPULATIONS25,26 Pediatrics Many of the products in this category are approved for use in children as young as 2 years of age. Use of prescription opioid cough and cold products are limited to adult patients aged 18 years and older due to the risks of these medicines outweighing their benefits in children younger than 18 years of age. Please consult the individual prescribing information for specific product information. Pregnancy Pregnancy category depends upon the component ingredients. Many are Pregnancy Category C, but consult the individual package inserts for specific product information. Renal Impairment Dosage adjustment may be warranted; however, specific guidelines in renal impairment are not available. Consult the individual package inserts for additional information. Hepatic Impairment Specific guidelines for dosage adjustments in patients with hepatic impairment are not available. Lower doses may be warranted due to metabolism of any one of the ingredients in a given product.

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Geriatrics The elderly are more susceptible to the anticholinergic effects of antihistamines. Reduced initial dosages may be needed. DOSAGES27,28

Drug Maximum Recommended Daily Dose Availability (Products containing drug) Adult Child Anticholinergics homatropine Ages: Tablet and syrup formulations 9 mg 6 to 12 years: 4.5 mg methscopolamine Safe and effective use has not Tablet, chewable tablet, and 12.5 mg been established in children syrup formulations scopolamine Safe and effective use has not Tablet and solution 2.4 mg been established in children formulations Antihistamines brompheniramine Ages: 6 to 11 years: 24 mg 2 to 5 years: 12 mg Tablet, capsule, solution, 48 mg 1 to 2 years: 6 mg syrup, and suspension 6 to 12 months: 3 mg formulations 3 to 6 months: 2 mg 1 to 3 months: 1 mg carbinoxamine Ages: > 6 years: 24 mg Solution, suspension, syrup 32 mg 3 to 6 years: 16 mg formulations 2 to 3 years: 8 mg chlorpheniramine Suspensions, solutions, extended-release tablets, Ages: chewable tablets 24 mg ≥ 6 years: 12 mg Extended release formulations 2 to 5 years: 4 mg are not recommended for children under age 6 years clemastine Ages: ≥ 12 years: 2 mg 2 mg Tablet and caplet formulations < 12 years: safe and effective use has not been established cyproheptadine Ages: 32 mg 7 to 14 years: 16 mg Syrup and tablet formulations 2 to 6 years: 12 mg dexbrompheniramine Ages: Tablets, extended-release ≥ 12 years: 12 mg 12 mg tablets, and syrup < 12 years: safe and effective formulations use has not been established

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Dosages (continued) Drug Maximum Recommended Daily Dose Availability (Products containing drug) Adult Child Antihistamines (continued) dexchlorpheniramine Extended release tablet and No maximum oral solution formulations Available for use in patients dosing information Extended release tablets are ages ≥ 2 available not recommended for use in children 3 to 5 years of age diphenhydramine Ages: Tablet and suspension 300 mg ≥ 6 years: 300 mg formulations doxylamine Ages: Suspension and chewable 25 mg ≥ 12 years: 25 mg tablet formulations hydroxyzine Ages: ≥ 6 years: 100 mg Tablets, capsules, and solution 400 mg < 6 years: 50 mg formulations Infants: safety and efficacy have not been established promethazine Ages: Adolescents: 100 mg Tablets and syrup 100 mg ≥ 2 years: lesser of 25 mg/dose formulations or 0.5 mg/pound/dose pyrilamine No maximum Available for use in patients Tablet, syrup, suspension, and dosing information ages ≥ 2 years chewable tablet formulations available triprolidine Ages: 6 to 11 years: 5 mg Tablet, solution, and 10 mg 4 to 5 years: 3.75 mg suspension formulations 2 to 3 years: 2.5 mg 4 months to 1 year: 1.25 mg Antitussives (opiate) codeine Ages: Tablet, capsule, syrup, and 360 mg Use limited to patients > 18 solution formulations years dihydrocodeine Use limited to patients > 18 Syrup and solution 90 mg years formulations hydrocodone 30 mg Use limited to patients > 18 Capsule and syrup (as an antitussive) years formulations

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Dosages (continued) Drug Maximum Recommended Daily Dose Availability (Products containing drug) Adult Child Antitussives (non-opiate) carbetapentane Ages: Tablets, capsules, extended- 6 to 12 years: 120 mg 240 mg release capsules, and 4 to 5 years: 30 mg suspension formulations 2 to 3 years: 15 mg chlophedianol Ages: 100 mg Solution formulations 2 to 12 years: 50 mg dextromethorphan Ages: Tablet, chewable tablet, 120 mg 6 to 11 years: 60 mg suspension, and solution 2 to 5 years: 30 mg formulations Decongestants phenylephrine Ages: Tablet, chewable tablet, 60 mg 6 to 12 years: 30 mg solution, and syrup 2 to 5 years: 15 mg formulations pseudoephedrine Ages: Chewable tablet, capsule, 240 mg 6 to 11 years: 120 mg solution, suspension, and 2 to 5 years: 60 mg syrup formulations Expectorants guaifenesin Ages: Extended-release capsule, 6 to 11 years: 1,200 mg 2,400 mg tablet, solution, suspension, 2 to 5 years: 600 mg and syrup formulations < 2 years: 300 mg CLINICAL TRIALS Search Strategy Studies were identified through searches performed on PubMed and review of information sent by manufacturers. Search strategy included the FDA-approved use of all drugs in this class. Randomized, comparative, controlled trials comparing agents within this class for the approved indications are considered the most relevant in this category. Studies included for analysis in the review were published in English, performed with human participants, and randomly allocated participants to comparison groups. In addition, studies must contain clearly stated, predetermined outcome measure(s) of known or probable clinical importance, use data analysis techniques consistent with the study question, and include follow-up (endpoint assessment) of at least 80% of participants entering the investigation. Despite some inherent bias found in all studies, including those sponsored and/or funded by pharmaceutical manufacturers, the studies in this therapeutic class review were determined to have results or conclusions that do not suggest systematic error in their experimental study design. While the potential influence of manufacturer sponsorship and/or funding must be considered, the studies in this review have also been evaluated for validity and importance. This class contains a vast number of combination cough and cold products whose constituent ingredients are available both as prescription and over-the-counter medications. All of the products contained in this monograph have supporting evidence related to the safety and efficacy of their constituent

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ingredients. There are numerous placebo-controlled studies available, but none that are comparative to other agents within this class. META-ANALYSIS A 2005 Cochrane Review suggested caution in determining clinically significant benefits of any of the non-antibiotic treatments of the common cold other than first-dose decongestants and antihistamine- decongestant combinations.29 The review included comparison of several products, including echinacea, heated humidifier air, dextromethorphan, guaifenesin, vitamin C, zinc lozenges, and 2 combination antihistamine-decongestant products. Dexbrompheniramine 6 mg in combination with pseudoephedrine 120 mg was administered twice daily for 1 week in 1 study. Another study evaluated loratadine 5 mg in combination with pseudoephedrine 120 mg twice daily for 4 days. The authors concluded that most non-antibiotic treatments for the common cold are probably not effective; however, dextromethorphan, guaifenesin, combination antihistamine-decongestants, first-dose nasal decongestants, and, possibly, zinc lozenges show promise. A 2012 Cochrane Review on the efficacy of OTC medications to treat an acute cough included 26 trials with antitussives, expectorants, mucolytics, antihistamines, antihistamine-decongestant combinations, and other combinations versus placebo with variable results.30 The review could not confirm clear evidence of efficacy of OTC medications to treat an acute cough. A 2007 meta-analysis was done to assess the efficacy of oral phenylephrine 10 mg as a nasal decongestant in the symptomatic relief from the common cold.31 To be included in the analysis, studies had to have a single-dose, randomized, placebo-controlled design; involve an orally-administered product in which phenylephrine 10 mg was the sole active ingredient; enroll patients with acute nasal congestion due to the common cold; evaluate nasal airway resistance as the efficacy endpoint; and have sufficient data points to allow re-analysis and/or meta-analysis of phenylephrine 10 mg and placebo. Eight studies met the inclusion criteria, involving seven cross-over studies of 113 subjects. Significant differences in favor of phenylephrine were seen in four of the 8 studies (p≤0.05). Phenylephrine was significantly more effective than placebo at the primary time points (45, 90, 120, and 180 minutes). This meta-analysis and re-analysis support the effectiveness of a single oral dose of phenylephrine 10 mg as a decongestant in adults with acute nasal congestion associated with the common cold. SUMMARY The common cold induces acute cough by directly irritating the upper airway structures. Viral infections of the airway can produce the common cold syndrome including rhinosinusitis. Active treatment of the symptoms associated with cough and cold may include combination products containing anticholinergics, first-generation antihistamines, opiate and non-opiate antitussives, decongestants, and expectorants. The available data do not result in any differentiation among the drugs in their particular class. These products are available in various combinations and individually as both prescription and OTC products. Awareness of the active ingredients is critical in ensuring proper dosing, patient safety, and effective use of these products.

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REFERENCES

1 Available at: https://www.clinicalkey.com/#!/ Accessed June 1, 2020. 2 Fashner J, Ericson K, Werner S. Treatment of the common cold in children and adults. Am Fam Physician. 2012;86(2):153-159. Available at: https://www.aafp.org/afp/2012/0715/p153.html. Accessed June 1, 2020. 3 Common cold. Available at: https://www.cdc.gov/dotw/common-cold/index.html . Accessed June 1, 2020. 4 Cough symptoms, causes, and risk factors. Available at: http://www.lung.org/lung-health-and-diseases/lung-disease-lookup/cough/cough-symptoms- causes-risks.html. Accessed June 1, 2020. 5 Cough. Available at: https://www.nhlbi.nih.gov/health-topics/cough. Accessed June 1, 2020. 6 Fashner J, Ericson K, Werner S. Treatment of the common cold in children and adults. Am Fam Physician. 2012;86(2):153-159. Available at: https://www.aafp.org/afp/2012/0715/p153.html. Accessed June 1, 2020. 7 Malesker MA, Callahan-Lyon P, Ireland B, et al. Pharmacologic and nonpharmacologic treatment for acute cough associated with the common cold. Chest Expert Panel Report. CHEST. 2017;152(5):1021-1037. Available at: http://www.chestnet.org/Guidelines-and-Resources/CHEST-Guideline-Topic- Areas/Clinical-Pulmonary. Accessed June 1, 2020. 8 Centers for Disease Control and Prevention (CDC). Infant deaths associated with cough and cold medications - two states, 2005. MMWR Weekly. 2007; 56:1–4. Available at: https://www.cdc.gov/mmwr/preview/mmwrhtml/mm5601a1.htm. Accessed June 1, 2020. 9 Food and Drug Administration, Division of Drug Risk Evaluation. Nonprescription Drug Advisory Committee meeting: cold, cough, allergy, bronchodilator, antiasthmatic drug products for over-the-counter human use. 2007:29. memorandum. Available at: http://www.fda.gov/ohrms/dockets/ac/07/briefing/2007-4323b1-02-FDA.pdf. Accessed June 1, 2020. 10 FDA. Use caution when giving cough and cold products to kids. Available at: https://www.fda.gov/drugs/special-features/use-caution-when-giving-cough- and-cold-products-kids. Accessed June 1, 2020. 11 FDA. OTC cough and cold products: not for infants and children under 2 years of age. Available at: https://www.fda.gov/consumers/consumer- updates/otc-cough-and-cold-products-not-infants-and-children-under-2-years-age. Accessed June 1, 2020. 12 Schaefer MK, Shehab N, Cohen AD, et al. Adverse events from cough and cold medications in children. Pediatrics. 2008;121;783-787. DOI: 10.1542/peds.2007-3638. 13 Lowry J, Leeder JS. Over-the counter medications: update on cough and cold preparations. Pediatrics in Review. 2015; 36(7): 286-297. DOI: 10.1542/pir.36-7-286. 14 Statement from CHPA on the voluntary label updates to oral OTC children’s cough and cold medicines. October 2008. Available at: https://www.chpa.org/10_07_08labelupdatecoughmedicine.aspx. Accessed June 1, 2020. 15 Revised Product Labels for Pediatric Over-the-Counter Cough and Cold Medicines. Available at http://www.cdc.gov/mmwr/preview/mmwrhtml/mm5743a5.htm. Accessed June 1, 2020. 16 American Academy of Pediatrics. Cough and Cold Medicine – Not for Children. 2016 Available at: https://www.aap.org/en-us/about-the-aap/aap-press- room/aap-press-room-media-center/Pages/Cough-and-Cold-Medicine-Not-for-Children.aspx. Accessed June 1, 2020. 17 Mazer-Amirshahi M, Reid N, van den Anker J, et al. Effect of cough and cold medication restriction and label changes on pediatric ingestions reported to United States poison centers. J Pediatr. 2013; 163(5):1372-6. DOI: 10.1016/j.jpeds.2013.04.054. 18 Hampton LM, Nguyen DB, Edwards JR, et al. Cough and cold medication adverse events after market withdrawal and labeling revision. Pediatrics. 2013; 132:1047. DOI: 10.1542/peds.2013-2236. 19 FDA Drug Safety Communication: FDA evaluating the potential risks of using codeine cough-and-cold medicines in children. Available at: http://www.fda.gov/Drugs/DrugSafety/ucm453125.htm. Accessed June 1, 2020. 20 FDA Drug Safety Communication: FDA restricts use of prescription codeine pain and cough medicines and tramadol pain medicines in children; recommends against use in breastfeeding women. Available at: https://www.fda.gov/Drugs/DrugSafety/ucm549679.htm. Accessed June 1, 2020. 21 FDA Drug Safety Communication: FDA requires labeling changes for prescription opioid cough and cold medicines to limit their use to adults 18 years and older. Available at: https://www.fda.gov/Drugs/DrugSafety/ucm590435.htm?utm_campaign=New%20FDA%20Drug%20Safety%20Communication%20on%20prescription%20 opioid%20cough%20and%20cold%20medicines&utm_medium=email&utm_source=Eloqua. Accessed June 1, 2020. 22 Clinical Pharmacology. Available at: http://www.clinicalpharmacology.com. Accessed June 1, 2020. 23 Available at: http://www.drugs.com/. Accessed June 1, 2020. 24 Clinical Pharmacology. Available at: http://www.clinicalpharmacology.com. Accessed June 1, 2020. 25 Available at: http://www.drugs.com/. Accessed June 1, 2020. 26 Clinical Pharmacology. Available at: http://www.clinicalpharmacology.com. Accessed June 1, 2020. 27 Available at: http://www.drugs.com/. Accessed June 1, 2020. 28 Clinical Pharmacology. Available at: http://www.clinicalpharmacology.com. Accessed June 1, 2020. 29 Arroll B. Non-antibiotic treatments for upper respiratory tract infections (common cold). Respir Med. 2005; 99(12):1477-84. 30 Smith SM, Schroeder K, Fahey T. Over-the-counter (OTC) medications for acute cough in children and adults in ambulatory settings. Cochrane Database of Systematic Reviews 2012, Issue 8. Art. No.: CD001831. DOI: 10.1002/14651858.CD001831.pub4. 31 Kollar C, Schneider H, Waksman J, Krusinska E. Meta-analysis of the efficacy of a single dose of phenylephrine 10 mg compared with placebo in adults with acute nasal congestion due to the common cold. Clin Ther. 2007 Jun;29(6):1057-70.

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Cough and Cold; Current Product Listing

LABEL NAME GENERIC NAME MANUFACTURER DRUG TYPE PROVIDER SYNERGIES BRAND NAME ROUTE PROVIDER SYNERGIES MARKET BASKET ALAHIST D 17.5-10 MG TABLET phenylephrine HCl/pheniramine POLY PHARMACEUT SSB ALAHIST D TABLET OTC (ORAL) COUGH AND COLD, COLD ALA-HIST IR 2 MG TABLET dexbrompheniramine maleate POLY PHARMACEUT SSB ALA-HIST IR TABLET OTC (ORAL) COUGH AND COLD, COLD ALAHIST PE 2-7.5 MG TABLET dexbrompheniramin/phenylephrin POLY PHARMACEUT SSB ALA-HIST PE TABLET OTC (ORAL) COUGH AND COLD, COLD ALLERGY MULTI-SYMPTOM CAPLET phenylephrine/acetaminophn/cpm generic GEN PHENYLEPHRINE/APAP/CHLORPHENIRAMINE TABLET OTC (ORAL) COUGH AND COLD, COLD ALLERGY-SEVERE SINUS HA CAPLET diphenhyd/phenyleph/acetaminop AMERISOURCE-GNP GEN DIPHENHYDRAMINE/PHENYLEPHRINE/APAP TABLET OTC (ORAL) COUGH AND COLD, COLD APRODINE TABLET triprolidine/pseudoephedrine MAJOR PHARMACEU GEN PSE/TRIPROLIDINE TABLET OTC (ORAL) COUGH AND COLD, COLD BENZEDREX INHALER propylhexedrine B.F ASCHER & CO SSB BENZEDREX INHALER OTC (NASAL) COUGH AND COLD, COLD BROHIST D 10-4 MG TABLET brompheniramine/phenylephrine ALLEGIS PHARMAC GEN PHENYLEPHRINE/BROMPHENIRAMINE TABLET OTC (ORAL) COUGH AND COLD, COLD CHEST CONGEST RLF 400 MG TAB guaifenesin generic GEN GUAIFENESIN 400 MG TABLET OTC (ORAL) COUGH AND COLD, COLD CHEST CONGESTION RELIEF SOLN guaifenesin RUGBY GEN GUAIFENESIN LIQUID OTC (ORAL) COUGH AND COLD, COLD CHEST-SINUS CONGST RLF TABLET guaifenesin/phenylephrine HCl AMERISOURCE-GNP GEN GUAIFENESIN/PHENYLEPHRINE TABLET OTC (ORAL) COUGH AND COLD, COLD CHILD MUCINEX CHEST 100 MG PKT guaifenesin RECKITT BENCKIS SSB MUCINEX GRAN PACK OTC (ORAL) COUGH AND COLD, COLD CHILD MUCINEX STUFFY NOSE SPRY oxymetazoline HCl RECKITT BENCKIS GEN OXYMETAZOLINE 12 HR NASAL SPRAY OTC (NASAL) COUGH AND COLD, COLD CHILDREN'S COLD-ALLERGY ELIXIR brompheniramine/phenylephrine TOPCO GEN PHENYLEPHRINE/BROMPHENIRAMINE SOLUTION OTC (ORAL) COUGH AND COLD, COLD CHILDREN'S MUCUS RELIEF LIQ guaifenesin TOPCO GEN GUAIFENESIN LIQUID OTC (ORAL) COUGH AND COLD, COLD CHILDS TRIACTING COLD-COUGH LQ phenylephrine/diphenhydramine TOPCO GEN PHENYLEPHRINE/DIPHENHYDRAMINE LIQUID OTC (ORAL) COUGH AND COLD, COLD COLD-ALLERGY ELIXIR brompheniramine/phenylephrine AMERISOURCE-GNP GEN PHENYLEPHRINE/BROMPHENIRAMINE SOLUTION OTC (ORAL) COUGH AND COLD, COLD COLD-ALLERGY TABLET chlorpheniramine/phenylephrine AMERISOURCE-GNP GEN PHENYLEPHRINE/CHLORPHENIRAMINE TABLET OTC (ORAL) COUGH AND COLD, COLD CONTAC COLD-FLU CAPLET phenylephrine/acetaminophn/cpm MEDA CONSUMER H SSB CONTAC TABLET OTC (C) (ORAL) COUGH AND COLD, COLD CONTAC COLD-FLU DAY CAPLET phenylephrine HCl/acetaminophn MEDA CONSUMER H GEN PHENYLEPHRINE/APAP TABLET OTC (ORAL) COUGH AND COLD, COLD DECONEX IR 385-10 MG TABLET guaifenesin/phenylephrine HCl POLY PHARMACEUT SSB DECONEX IR TABLET OTC (ORAL) COUGH AND COLD, COLD DELSYM COUGH-COLD NIGHTTIME LQ diphenhyd/phenyleph/acetaminop RECKITT BENCKIS SSB DELSYM COUGH & COLD LIQUID OTC (C) (ORAL) COUGH AND COLD, COLD DEXBROMPHENIR-PHENYLEPH 2-10MG dexbrompheniramin/phenylephrin WESTMINSTER PHA GEN DEXBROMPHENIRAMINE/PHENYLEPHRINE OTC (ORAL) COUGH AND COLD, COLD DOXYLAMINE-PHENYLEPH 7.5-10 MG doxylamine/phenylephrine HCl WESTMINSTER PHA GEN DOXYLAMINE/PHENYLEPHRINE OTC (ORAL) COUGH AND COLD, COLD DURAVENT PE TABLET guaifenesin/phenylephrine HCl ALLEGIS PHARMAC SSB DURAVENT PE TABLET OTC (ORAL) COUGH AND COLD, COLD ED A-HIST LIQUID chlorpheniramine/phenylephrine EDWARDS PHARM. SSB ED A-HIST LIQUID OTC (ORAL) COUGH AND COLD, COLD ED BRON GP LIQUID guaifenesin/phenylephrine HCl EDWARDS PHARM. SSB ED BRON GP LIQUID OTC (ORAL) COUGH AND COLD, COLD ED-A-HIST 4 MG-10 MG TABLET chlorpheniramine/phenylephrine EDWARDS PHARM. SSB ED A-HIST TABLET OTC (ORAL) COUGH AND COLD, COLD FLU RELIEF THERAPY NIGHT LIQ diphenhyd/phenyleph/acetaminop AMERISOURCE-GNP GEN DIPHENHYDRAMINE/PHENYLEPHRINE/APAP LIQUID OTC (ORAL) COUGH AND COLD, COLD GNP ALLERGY PLUS-SINUS HA CPLT diphenhyd/phenyleph/acetaminop AMERISOURCE-GNP GEN DIPHENHYDRAMINE/PHENYLEPHRINE/APAP TABLET OTC (ORAL) COUGH AND COLD, COLD GNP NASAL SPRAY 0.05% oxymetazoline HCl AMERISOURCE-GNP GEN OXYMETAZOLINE MIST OTC (NASAL) COUGH AND COLD, COLD GS NASAL FOUR 1% NASAL SPRAY phenylephrine HCl PERRIGO/GOODSEN GEN PHENYLEPHRINE FOUR SPRAY OTC (NASAL) COUGH AND COLD, COLD GS NASAL SPRAY 0.05% oxymetazoline HCl PERRIGO/GOODSEN GEN OXYMETAZOLINE 12 HR NASAL SPRAY OTC (NASAL) COUGH AND COLD, COLD GS SINUS CONGESTION-PAIN CPLT phenylephrine HCl/acetaminophn PERRIGO/GOODSEN GEN PHENYLEPHRINE/APAP TABLET OTC (ORAL) COUGH AND COLD, COLD GS SINUS NASAL SPRAY 0.05% oxymetazoline HCl PERRIGO/GOODSEN GEN OXYMETAZOLINE 12 HR NASAL SPRAY OTC (NASAL) COUGH AND COLD, COLD GS TUSSIN MUCUS-CONG 100 MG/5 guaifenesin PERRIGO/GOODSEN GEN GUAIFENESIN LIQUID OTC (ORAL) COUGH AND COLD, COLD GS TUSSIN MUCUS-CONG 200 MG/10 guaifenesin PERRIGO/GOODSEN GEN GUAIFENESIN LIQUID OTC (ORAL) COUGH AND COLD, COLD GUAIFENESIN 100 MG/5 ML LIQUID guaifenesin METHOD PHARMACE GEN GUAIFENESIN LIQUID OTC (ORAL) COUGH AND COLD, COLD GUAIFENESIN 100 MG/5 ML SOLN guaifenesin generic GEN GUAIFENESIN LIQUID OTC (ORAL) COUGH AND COLD, COLD GUAIFENESIN 200 MG TABLET guaifenesin MAJOR PHARMACEU GEN GUAIFENESIN 200 MG TABLET OTC (ORAL) COUGH AND COLD, COLD GUAIFENESIN 200 MG/10 ML SOLN guaifenesin generic GEN GUAIFENESIN LIQUID OTC (ORAL) COUGH AND COLD, COLD GUAIFENESIN 300 MG/15 ML SOLN guaifenesin PHARMACEUTICAL GEN GUAIFENESIN LIQUID OTC (ORAL) COUGH AND COLD, COLD GUAIFENESIN-PSE 375-60 MG TAB guaifenesin/pseudoephedrne HCl XSPIRE PHARMA GEN GUAIFENESIN/PSEUDOEPHEDRNE TABLET OTC (ORAL) COUGH AND COLD, COLD GUAIFENESIN-PSE ER 1200-120 MG guaifenesin/pseudoephedrne HCl DR.REDDY'S LAB GEN GUAIFENESIN/PSE TABLET ER OTC (ORAL) COUGH AND COLD, COLD GUAIFENESIN-PSE ER 600-60 MG guaifenesin/pseudoephedrne HCl generic GEN GUAIFENESIN/PSE TABLET ER OTC (ORAL) COUGH AND COLD, COLD HISTEX-PE SYRUP phenylephrine HCl/triprolidine ALLEGIS PHARMAC SSB HISTEX-PE LIQUID OTC (ORAL) COUGH AND COLD, COLD HM ADULT TUSSIN CHEST CONG LIQ guaifenesin HM-STRATEGIC SO GEN GUAIFENESIN LIQUID OTC (ORAL) COUGH AND COLD, COLD HM ALLERGY MULTI-SYMPTOM CPLT phenylephrine/acetaminophn/cpm HM-STRATEGIC SO GEN PHENYLEPHRINE/APAP/CHLORPHENIRAMINE TABLET OTC (ORAL) COUGH AND COLD, COLD HM CHEST CONGEST RLF 400 MG TB guaifenesin HM-STRATEGIC SO GEN GUAIFENESIN 400 MG TABLET OTC (ORAL) COUGH AND COLD, COLD HM CHILD ALLERGY-CONGEST SOLN phenylephrine/diphenhydramine HM-STRATEGIC SO GEN PHENYLEPHRINE/DIPHENHYDRAMINE SOLUTION OTC (ORAL) COUGH AND COLD, COLD HM CHILD COLD-ALLERGY ELIXIR brompheniramine/phenylephrine HM-STRATEGIC SO GEN PHENYLEPHRINE/BROMPHENIRAMINE SOLUTION OTC (ORAL) COUGH AND COLD, COLD HM CHILD'S DIBROMM COLD-ALLGY brompheniramine/phenylephrine HM-STRATEGIC SO GEN PHENYLEPHRINE/BROMPHENIRAMINE SOLUTION OTC (ORAL) COUGH AND COLD, COLD HM COLD-SINUS RELIEF CAPLET ibuprofen/pseudoephedrine HCl HM-STRATEGIC SO GEN IBUPROFEN/PSE TABLET OTC (ORAL) COUGH AND COLD, COLD HM MUCUS ER 1,200 MG TABLET guaifenesin HM-STRATEGIC SO GEN GUAIFENESIN TABLET ER OTC (ORAL) COUGH AND COLD, COLD HM MUCUS ER 600 MG TABLET guaifenesin HM-STRATEGIC SO GEN GUAIFENESIN TABLET ER OTC (ORAL) COUGH AND COLD, COLD HM MUCUS RELIEF ER 1,200 MG TB guaifenesin HM-STRATEGIC SO GEN GUAIFENESIN TABLET ER OTC (ORAL) COUGH AND COLD, COLD HM MUCUS RELIEF ER 600 MG TAB guaifenesin HM-STRATEGIC SO GEN GUAIFENESIN TABLET ER OTC (ORAL) COUGH AND COLD, COLD HM MUCUS RLF D ER 600-60 MG TB guaifenesin/pseudoephedrne HCl HM-STRATEGIC SO GEN GUAIFENESIN/PHENYLEPHRINE TABLET OTC (ORAL) COUGH AND COLD, COLD HM NOSE DROPS phenylephrine HCl HM-STRATEGIC SO GEN PHENYLEPHRINE NOSE DROPS OTC (NASAL) COUGH AND COLD, COLD HM ORIGINAL NASAL SPRAY 0.05% oxymetazoline HCl HM-STRATEGIC SO GEN OXYMETAZOLINE 12 HR NASAL SPRAY OTC (NASAL) COUGH AND COLD, COLD HM SEVERE COLD COUGH-FLU PKT diphenhyd/phenyleph/acetaminop HM-STRATEGIC SO GEN DIPHENHYDRAMINE/PHENYLEPHRINE/APAP POWDER PACK OTC (ORAL) COUGH AND COLD, COLD HM SINUS AND COLD-D CAPLET naproxen sodium/pseudoephedrin HM-STRATEGIC SO GEN NAPROXEN/PSE TABLET OTC (ORAL) COUGH AND COLD, COLD HM SINUS NASAL SPRAY 0.05% oxymetazoline HCl HM-STRATEGIC SO GEN OXYMETAZOLINE 12 HR NASAL SPRAY OTC (NASAL) COUGH AND COLD, COLD HM SINUS SEVERE CAPLET guaifen/phenyleph/acetaminophn HM-STRATEGIC SO GEN GUAIFENESIN/PHENYLEPHRINE/APAP TABLET OTC (ORAL) COUGH AND COLD, COLD IBUPROFEN COLD-SINUS CPLT ibuprofen/pseudoephedrine HCl AMERISOURCE-GNP GEN IBUPROFEN/PSE TABLET OTC (ORAL) COUGH AND COLD, COLD LIQUITUSS GG 200 MG/5 ML LIQ guaifenesin CAPELLON SSB LIQUITUSS GG LIQUID OTC (ORAL) COUGH AND COLD, COLD LODRANE D CAPSULE brompheniramin/pseudoephedrine VALEANT/BAUSCH SSB LODRANE D CAPSULE OTC (ORAL) COUGH AND COLD, COLD LOHIST-D LIQUID chlorpheniramine/pseudoephed LARKEN LABS SSB LOHIST-D LIQUID OTC (ORAL) COUGH AND COLD, COLD MAXIFED TABLET guaifenesin/pseudoephedrne HCl MCR AMERICAN PH SSB MAXIFED TABLET OTC (ORAL) COUGH AND COLD, COLD MAXIFED TR 30-1.25 MG TABLET triprolidine/pseudoephedrine MCR AMERICAN PH SSB MAXIFED TR TABLET OTC (ORAL) COUGH AND COLD, COLD MAXI-TUSS PE JR LIQUID guaifenesin/phenylephrine HCl MCR AMERICAN PH SSB MAXI-TUSS PE JR LIQUID OTC (ORAL) COUGH AND COLD, COLD MAXI-TUSS PE LIQUID brompheniramine/phenylephrine MCR AMERICAN PH SSB MAXI-TUSS PE LIQUID OTC (ORAL) COUGH AND COLD, COLD MAXI-TUSS PE MAX LIQUID guaifenesin/phenylephrine HCl MCR AMERICAN PH GEN MAXI-TUSS PE MAX LIQUID OTC (ORAL) COUGH AND COLD, COLD MAXI-TUSS TR SYRUP triprolidine/pseudoephedrine MCR AMERICAN PH GEN MAXI-TUSS TR SYRUP OTC (ORAL) COUGH AND COLD, COLD MUCINEX ER 1,200 MG TABLET guaifenesin RECKITT BENCKIS SSB MUCINEX ER TABLET OTC (ORAL) COUGH AND COLD, COLD MUCINEX ER 600 MG TABLET guaifenesin RECKITT BENCKIS SSB MUCINEX ER TABLET OTC (ORAL) COUGH AND COLD, COLD MUCINEX FAST-MAX CHEST-CONGEST guaifenesin RECKITT BENCKIS GEN GUAIFENESIN LIQUID OTC (ORAL) COUGH AND COLD, COLD MUCINEX FAST-MAX COLD-SINUS TB guaifen/phenyleph/acetaminophn RECKITT BENCKIS SSB MUCINEX FAST-MAX COLD-SINUS TABLET OTC (ORAL) COUGH AND COLD, COLD MUCINEX FAST-MAX CONGST-HA LIQ guaifen/phenyleph/acetaminophn RECKITT BENCKIS SSB MUCINEX FAST-MAX CONG-HEADACHE LIQUID OTC (ORAL) COUGH AND COLD, COLD MUCINEX SINUS-MAX DAY-NT CAPLT diphenhyd/pe/acetaminophen/gg RECKITT BENCKIS SSB MUCINEX SINUS-MAX DAY-NIGHT TABLET SEQUELS OTC (ORAL) COUGH AND COLD, COLD MUCINEX SINUS-MAX NASAL SPRAY oxymetazoline HCl RECKITT BENCKIS GEN MUCINEX SINUS-MAX SPRAY OTC (NASAL) COUGH AND COLD, COLD MUCINEX SINUS-MAX SEVERE CPLT guaifen/phenyleph/acetaminophn RECKITT BENCKIS SSB MUCINEX SINUS-MAX TABLET OTC (ORAL) COUGH AND COLD, COLD MUCINEX SINUS-MAX SEVERE LIQ guaifen/phenyleph/acetaminophn RECKITT BENCKIS SSB MUCINEX SINUS-MAX LIQUID OTC (ORAL) COUGH AND COLD, COLD MUCOSA 400 MG TABLET guaifenesin TIME-CAP LABS GEN GUAIFENESIN 400 MG TABLET OTC (ORAL) COUGH AND COLD, COLD MUCUS D ER 600-60 MG TABLET guaifenesin/pseudoephedrne HCl PERRIGO CO. GEN GUAIFENESIN/PSE TABLET ER OTC (ORAL) COUGH AND COLD, COLD MUCUS ER 600 MG TABLET guaifenesin AMERISOURCE-GNP GEN GUAIFENESIN TABLET ER OTC (ORAL) COUGH AND COLD, COLD MUCUS RELIEF 400 MG TABLET guaifenesin generic GEN GUAIFENESIN 400 MG TABLET OTC (ORAL) COUGH AND COLD, COLD MUCUS RELIEF COLD-SINUS CAPLET guaifen/phenyleph/acetaminophn AMERISOURCE-GNP GEN GUAIFENESIN/PHENYLEPHRINE/APAP TABLET OTC (ORAL) COUGH AND COLD, COLD MUCUS RELIEF D ER 600-60 MG TB guaifenesin/pseudoephedrne HCl generic GEN GUAIFENESIN/PHENYLEPHRINE TABLET OTC (ORAL) COUGH AND COLD, COLD MUCUS RELIEF ER 1,200 MG TAB guaifenesin generic GEN GUAIFENESIN TABLET ER OTC (ORAL) COUGH AND COLD, COLD MUCUS RELIEF ER 600 MG TABLET guaifenesin generic GEN GUAIFENESIN TABLET ER OTC (ORAL) COUGH AND COLD, COLD MUCUS RELIEF PE TABLET guaifenesin/phenylephrine HCl LEADER GEN GUAIFENESIN/PHENYLEPHRINE TABLET OTC (ORAL) COUGH AND COLD, COLD MUCUS RELIEF SINUS TABLET guaifenesin/phenylephrine HCl MAJOR PHARMACEU GEN GUAIFENESIN/PHENYLEPHRINE TABLET OTC (ORAL) COUGH AND COLD, COLD MUCUS RLF CHEST CONGEST 200 MG guaifenesin LEADER GEN GUAIFENESIN 200 MG TABLET OTC (ORAL) COUGH AND COLD, COLD NASAL DECONGESTANT 0.05% SPRAY oxymetazoline HCl MAJOR PHARMACEU GEN OXYMETAZOLINE 12 HR NASAL SPRAY OTC (NASAL) COUGH AND COLD, COLD NASAL FOUR 1% NASAL SPRAY phenylephrine HCl TOPCO GEN PHENYLEPHRINE FOUR SPRAY OTC (NASAL) COUGH AND COLD, COLD NASAL SPRAY 0.05% oxymetazoline HCl generic GEN OXYMETAZOLINE 12 HR NASAL SPRAY OTC (NASAL) COUGH AND COLD, COLD NASAL SPRAY 1% phenylephrine HCl AMERISOURCE-GNP GEN PHENYLEPHRINE FOUR SPRAY OTC (NASAL) COUGH AND COLD, COLD NASAL SPRAY ORIGINAL 0.05% oxymetazoline HCl AMERISOURCE-GNP GEN OXYMETAZOLINE 12 HR NASAL SPRAY OTC (NASAL) COUGH AND COLD, COLD NASOPEN PE LIQUID thonzylamine/phenylephrine G.M. PHARM SSB NASOPEN PE LIQUID OTC (ORAL) COUGH AND COLD, COLD NIGHT SEVERE COLD-COUGH PKT diphenhyd/phenyleph/acetaminop LEADER GEN DIPHENHYDRAMINE/PHENYLEPHRINE/APAP POWDER PACK OTC (ORAL) COUGH AND COLD, COLD NO DRIP 0.05% NASAL SPRAY oxymetazoline HCl generic GEN OXYMETAZOLINE 12 HR NASAL SPRAY OTC (NASAL) COUGH AND COLD, COLD NOHIST-LQ LIQUID chlorpheniramine/phenylephrine LARKEN LABS SSB NOHIST-LQ LIQUID OTC (ORAL) COUGH AND COLD, COLD NOSE DROPS phenylephrine HCl AMERISOURCE-GNP GEN PHENYLEPHRINE NOSE DROPS OTC (NASAL) COUGH AND COLD, COLD PAIN RELIEF ALLERGY CAPLET phenylephrine/acetaminophn/cpm AMERISOURCE-GNP GEN PHENYLEPHRINE/APAP/CHLORPHENIRAMINE TABLET OTC (ORAL) COUGH AND COLD, COLD POLY HIST FORTE 10.5-10 MG TAB doxylamine/phenylephrine HCl POLY PHARMACEUT SSB POLY HIST FORTE TABLET OTC (ORAL) COUGH AND COLD, COLD POLY HIST FORTE 7.5-10 MG TAB doxylamine/phenylephrine HCl POLY PHARMACEUT SSB POLY HIST FORTE TABLET OTC (ORAL) COUGH AND COLD, COLD POLY-VENT IR TABLET guaifenesin/pseudoephedrne HCl POLY PHARMACEUT SSB POLY-VENT IR TABLET OTC (ORAL) COUGH AND COLD, COLD PROMETHAZINE VC ORAL SOLUTION phenylephrine HCl/prometh HCl PHARMACEUTICAL GEN PHENYLEPHRINE/PROMETHAZINE SYRUP (ORAL) COUGH AND COLD, COLD PROMETHAZINE-PHENYLEPHRINE SYR phenylephrine HCl/prometh HCl HI-TECH/AKORN C GEN PHENYLEPHRINE/PROMETHAZINE SYRUP (ORAL) COUGH AND COLD, COLD QC ALLERGY & SINUS HA CAPLET diphenhyd/phenyleph/acetaminop CHAIN DRUG GEN DIPHENHYDRAMINE/PHENYLEPHRINE/APAP TABLET OTC (ORAL) COUGH AND COLD, COLD QC ALLERGY RELIEF MUL-SYM CPLT phenylephrine/acetaminophn/cpm CHAIN DRUG GEN PHENYLEPHRINE/APAP/CHLORPHENIRAMINE TABLET OTC (ORAL) COUGH AND COLD, COLD QC COLD RELIEF PLUS EFF TABLET chlorphenir/phenyleph/aspirin CHAIN DRUG GEN CHLORPHENIRAMINE/PHENYLEPHRINE/ASA TABLET EFF OTC (ORAL) COUGH AND COLD, COLD QC MUCUS RELIEF 400 MG CAPLET guaifenesin CHAIN DRUG GEN GUAIFENESIN 400 MG TABLET OTC (ORAL) COUGH AND COLD, COLD QC MUCUS RELIEF ER 1,200 MG TB guaifenesin CHAIN DRUG GEN GUAIFENESIN TABLET ER OTC (ORAL) COUGH AND COLD, COLD QC MUCUS RELIEF ER 600 MG TAB guaifenesin CHAIN DRUG GEN GUAIFENESIN TABLET ER OTC (ORAL) COUGH AND COLD, COLD QC NIGHT SEVERE COLD-COUGH PKT diphenhyd/phenyleph/acetaminop CHAIN DRUG GEN DIPHENHYDRAMINE/PHENYLEPHRINE/APAP POWDER PACK OTC (ORAL) COUGH AND COLD, COLD QC SINUS PAIN RELIEF CAPLET phenylephrine HCl/acetaminophn CHAIN DRUG GEN PHENYLEPHRINE/APAP TABLET OTC (ORAL) COUGH AND COLD, COLD QC TUSSIN MUCUS-CONG 200 MG/10 guaifenesin CHAIN DRUG GEN GUAIFENESIN LIQUID OTC (ORAL) COUGH AND COLD, COLD QC VAPOR INHALER levmetamfetamine CHAIN DRUG GEN LEVMETAMFETAMINE INHALER OTC (NASAL) COUGH AND COLD, COLD RESCON TABLET dexchlorpheniramin/pseudoephed CAPELLON SSB RESCON TABLET OTC (ORAL) COUGH AND COLD, COLD ROBAFEN 200 MG/10 ML SYRUP guaifenesin MAJOR PHARMACEU GEN GUAIFENESIN LIQUID OTC (ORAL) COUGH AND COLD, COLD

1 Cough and Cold; Current Product Listing

LABEL NAME GENERIC NAME MANUFACTURER DRUG TYPE PROVIDER SYNERGIES BRAND NAME ROUTE PROVIDER SYNERGIES MARKET BASKET RU-HIST D 10-4 MG TABLET brompheniramine/phenylephrine ALLEGIS PHARMAC GEN PHENYLEPHRINE/BROMPHENIRAMINE TABLET OTC (ORAL) COUGH AND COLD, COLD RYMED TABLET dexchlorpheniram/phenylephrine EDWARDS PHARM. SSB RYMED TABLET OTC (ORAL) COUGH AND COLD, COLD RYNEX PE LIQUID brompheniramine/phenylephrine EDWARDS PHARM. SSB RYNEX PE SOLUTION OTC (ORAL) COUGH AND COLD, COLD SILTUSSIN SA 100 MG/5 ML SYR guaifenesin SILARX/LANNETT GEN GUAIFENESIN LIQUID OTC (ORAL) COUGH AND COLD, COLD SINUS CONGESTION-PAIN CAPLET phenylephrine HCl/acetaminophn generic GEN PHENYLEPHRINE/APAP TABLET OTC (ORAL) COUGH AND COLD, COLD SINUS CONG-PAIN DAY-NIGHT CPL phenylephrine/acetaminophn/cpm AMERISOURCE-GNP GEN PHENYLEPHRINE/APAP/CHLORPHENIRAMINE TABLET SEQUELS OTC (ORAL) COUGH AND COLD, COLD SINUS CONGST-PAIN 325-200-5 MG guaifen/phenyleph/acetaminophn LEADER GEN GUAIFENESIN/PHENYLEPHRINE/APAP TABLET OTC (ORAL) COUGH AND COLD, COLD SINUS PRESSURE-PAIN CAPLET phenylephrine HCl/acetaminophn LEADER GEN PHENYLEPHRINE/APAP TABLET OTC (ORAL) COUGH AND COLD, COLD SINUS RELIEF 0.05% NASAL SPRAY oxymetazoline HCl TOPCO GEN OXYMETAZOLINE MIST OTC (NASAL) COUGH AND COLD, COLD SINUS RELIEF 1% NASAL SPRAY phenylephrine HCl LEADER GEN SINUS RELIEF SPRAY OTC (NASAL) COUGH AND COLD, COLD SINUS RELIEF PRESS-PAIN CAPLET guaifen/phenyleph/acetaminophn AMERISOURCE-GNP GEN GUAIFENESIN/PHENYLEPHRINE/APAP TABLET OTC (ORAL) COUGH AND COLD, COLD SINUS RELIEF SEV CONGEST CPLT guaifen/phenyleph/acetaminophn AMERISOURCE-GNP GEN GUAIFENESIN/PHENYLEPHRINE/APAP TABLET OTC (ORAL) COUGH AND COLD, COLD SINUS RELIEF-CONG-PAIN CAPLET phenylephrine/acetaminophn/cpm AMERISOURCE-GNP GEN PHENYLEPHRINE/APAP/CHLORPHENIRAMINE TABLET OTC (ORAL) COUGH AND COLD, COLD SINUS-ALLERGY PE 4-10 MG TAB chlorpheniramine/phenylephrine AMERISOURCE-GNP GEN PHENYLEPHRINE/CHLORPHENIRAMINE TABLET OTC (ORAL) COUGH AND COLD, COLD SINUS-HEADACHE 5-325 MG CAPLET phenylephrine HCl/acetaminophn LEADER GEN PHENYLEPHRINE/APAP TABLET OTC (ORAL) COUGH AND COLD, COLD SM CHEST CONG RELIEF PE CAPLET guaifenesin/phenylephrine HCl SM-STRATEGIC SO GEN GUAIFENESIN/PHENYLEPHRINE TABLET OTC (ORAL) COUGH AND COLD, COLD SM CHEST CONGESTION 400MG CPLT guaifenesin SM-STRATEGIC SO GEN GUAIFENESIN 400 MG TABLET OTC (ORAL) COUGH AND COLD, COLD SM CHEST CONGESTION CAPLET guaifenesin/acetaminophen SM-STRATEGIC SO GEN GUAIFENESIN/APAP TABLET OTC (ORAL) COUGH AND COLD, COLD SM CHILD COLD-ALLERGY LIQUID brompheniramine/phenylephrine SM-STRATEGIC SO GEN PHENYLEPHRINE/BROMPHENIRAMINE SOLUTION OTC (ORAL) COUGH AND COLD, COLD SM COLD-ALLERGY PE TABLET chlorpheniramine/phenylephrine SM-STRATEGIC SO GEN PHENYLEPHRINE/CHLORPHENIRAMINE TABLET OTC (ORAL) COUGH AND COLD, COLD SM IBUPROFEN COLD & SINUS CPLT ibuprofen/pseudoephedrine HCl SM-STRATEGIC SO GEN IBUPROFEN/PSE TABLET OTC (ORAL) COUGH AND COLD, COLD SM MUCUS ER 600 MG TABLET guaifenesin SM-STRATEGIC SO GEN GUAIFENESIN TABLET ER OTC (ORAL) COUGH AND COLD, COLD SM MUCUS RELIEF D ER 600-60 MG guaifenesin/pseudoephedrne HCl SM-STRATEGIC SO GEN GUAIFENESIN/PHENYLEPHRINE TABLET OTC (ORAL) COUGH AND COLD, COLD SM MUCUS RELIEF ER 600 MG TAB guaifenesin SM-STRATEGIC SO GEN GUAIFENESIN TABLET ER OTC (ORAL) COUGH AND COLD, COLD SM MUCUS-ER MAX 1,200 MG TAB guaifenesin SM-STRATEGIC SO GEN GUAIFENESIN TABLET ER OTC (ORAL) COUGH AND COLD, COLD SM NASAL 0.05% SPRAY oxymetazoline HCl SM-STRATEGIC SO GEN OXYMETAZOLINE MIST OTC (NASAL) COUGH AND COLD, COLD SM NASAL SPRAY 0.05% oxymetazoline HCl SM-STRATEGIC SO GEN OXYMETAZOLINE 12 HR NASAL SPRAY OTC (NASAL) COUGH AND COLD, COLD SM NASAL SPRAY SINUS oxymetazoline HCl SM-STRATEGIC SO GEN OXYMETAZOLINE 12 HR NASAL SPRAY OTC (NASAL) COUGH AND COLD, COLD SM NOSE DROPS phenylephrine HCl SM-STRATEGIC SO GEN PHENYLEPHRINE NOSE DROPS OTC (NASAL) COUGH AND COLD, COLD SM SINUS AND COLD-D CAPLET naproxen sodium/pseudoephedrin SM-STRATEGIC SO GEN NAPROXEN/PSE TABLET OTC (ORAL) COUGH AND COLD, COLD SM SINUS MAXIMUM STRENGTH CPLT phenylephrine HCl/acetaminophn SM-STRATEGIC SO GEN PHENYLEPHRINE/APAP TABLET OTC (ORAL) COUGH AND COLD, COLD SM SINUS SEVERE CAPLET guaifen/phenyleph/acetaminophn SM-STRATEGIC SO GEN GUAIFENESIN/PHENYLEPHRINE/APAP TABLET OTC (ORAL) COUGH AND COLD, COLD SM SINUS-ALLERGY PE TABLET chlorpheniramine/phenylephrine SM-STRATEGIC SO GEN PHENYLEPHRINE/CHLORPHENIRAMINE TABLET OTC (ORAL) COUGH AND COLD, COLD SM TUSSIN MUCUS-CONG 200 MG/10 guaifenesin SM-STRATEGIC SO GEN GUAIFENESIN LIQUID OTC (ORAL) COUGH AND COLD, COLD STAHIST AD TABLET chlorcyclizine/pseudoephedrine MAGNA PHARM SSB STAHIST AD TABLET OTC (ORAL) COUGH AND COLD, COLD STAHIST LIQUID dexchlorpheniram/phenylephrine MAGNA PHARM SSB STAHIST LIQUID OTC (ORAL) COUGH AND COLD, COLD STAHIST TP 10-2.5 MG TABLET phenylephrine HCl/triprolidine MAGNA PHARM SSB STAHIST TP TABLET OTC (ORAL) COUGH AND COLD, COLD SUDOGEST COLD AND ALLERGY TAB chlorpheniramine/pseudoephed MAJOR PHARMACEU GEN PSE/CHLORPHENIRAMINE TABLET OTC (ORAL) COUGH AND COLD, COLD SUDOGEST SINUS AND ALLERGY TAB chlorpheniramine/pseudoephed MAJOR PHARMACEU GEN PSE/CHLORPHENIRAMINE TABLET OTC (ORAL) COUGH AND COLD, COLD TUSNEL PEDI 25-1.25 MG/ML DROP guaifenesin/phenylephrine HCl LLORENS PHARM SSB TUSNEL PEDIATRIC DROPS OTC (ORAL) COUGH AND COLD, COLD TUSNEL PEDIATRIC DROPS guaifenesin/pseudoephedrne HCl LLORENS PHARM SSB TUSNEL PEDIATRIC DROPS OTC (ORAL) COUGH AND COLD, COLD TUSNEL-EX 100 MG/5 ML LIQUID guaifenesin LLORENS PHARM GEN GUAIFENESIN LIQUID OTC (ORAL) COUGH AND COLD, COLD TUSSIN 100 MG/5 ML SYRUP guaifenesin AMERISOURCE-GNP GEN GUAIFENESIN LIQUID OTC (ORAL) COUGH AND COLD, COLD TUSSIN 400 MG TABLET guaifenesin AMERISOURCE-GNP GEN GUAIFENESIN 400 MG TABLET OTC (ORAL) COUGH AND COLD, COLD TUSSIN CHEST CONGESTION LIQUID guaifenesin TOPCO GEN GUAIFENESIN LIQUID OTC (ORAL) COUGH AND COLD, COLD TUSSIN HONEY SYRUP guaifenesin SM-STRATEGIC SO GEN GUAIFENESIN LIQUID OTC (ORAL) COUGH AND COLD, COLD TUSSIN MUCUS-CONG 200 MG/10 guaifenesin generic GEN GUAIFENESIN LIQUID OTC (ORAL) COUGH AND COLD, COLD V-R VALU-TAPP ELIXIR brompheniramin/pseudoephedrine SM-STRATEGIC SO GEN PSE/BROMPHENIRAMINE LIQUID OTC (ORAL) COUGH AND COLD, COLD CAPCOF LIQUID chlorpheniramine/PE/codeine CAPITAL PHARMAC SSB CAPCOF LIQUID OTC (ORAL) COUGH AND COLD, NARCOTIC CODEINE-GUAIFEN 10-100 MG/5 ML codeine phosphate/guaifenesin generic GEN GUAIFENESIN/CODEINE LIQUID OTC (ORAL) COUGH AND COLD, NARCOTIC GUAIATUSSIN AC LIQUID codeine phosphate/guaifenesin HI-TECH/AKORN C GEN GUAIFENESIN/CODEINE LIQUID OTC (ORAL) COUGH AND COLD, NARCOTIC GUAIFEN-CODEINE 100-10 MG/5 ML codeine phosphate/guaifenesin generic GEN GUAIFENESIN/CODEINE LIQUID OTC (ORAL) COUGH AND COLD, NARCOTIC GUAIFEN-CODEINE 200-20 MG/10ML codeine phosphate/guaifenesin PHARMACEUTICAL GEN GUAIFENESIN/CODEINE LIQUID OTC (ORAL) COUGH AND COLD, NARCOTIC GUAIFENESIN-CODEINE SYRUP codeine phosphate/guaifenesin PHARMACEUTICAL GEN GUAIFENESIN/CODEINE LIQUID OTC (ORAL) COUGH AND COLD, NARCOTIC HISTEX-AC SYRUP triprolidine/phenyleph/codeine ALLEGIS PHARMAC SSB HISTEX-AC SYRUP OTC (ORAL) COUGH AND COLD, NARCOTIC HYCODAN 5 MG-1.5 MG/5 ML SOLN hydrocodone bit/homatrop me-br GENUS LIFESCIEN GEN HYDROCODONE/HOMATROPINE SYRUP (ORAL) COUGH AND COLD, NARCOTIC HYDROCODONE-CHLORPHEN ER SUSP hydrocodone/chlorphen p-stirex generic GEN HYDROCODONE/CHLORPHENIRAMINE SUSPENSION ER 12H (ORAL) COUGH AND COLD, NARCOTIC HYDROCODONE-HOMATROPINE 5-1.5 hydrocodone bit/homatrop me-br generic GEN HYDROCODONE/HOMATROPINE TABLET (ORAL) COUGH AND COLD, NARCOTIC HYDROCODONE-HOMATROPINE SOLN hydrocodone bit/homatrop me-br generic GEN HYDROCODONE/HOMATROPINE SYRUP (ORAL) COUGH AND COLD, NARCOTIC HYDROCODONE-HOMATROPINE SYRUP hydrocodone bit/homatrop me-br PHARMACEUTICAL GEN HYDROCODONE/HOMATROPINE SYRUP (ORAL) COUGH AND COLD, NARCOTIC HYDROMET 5 MG-1.5 MG/5 ML SOLN hydrocodone bit/homatrop me-br ACTAVIS/TEVA GEN HYDROCODONE/HOMATROPINE SYRUP (ORAL) COUGH AND COLD, NARCOTIC MAXI-TUSS AC LIQUID codeine phosphate/guaifenesin MCR AMERICAN PH GEN GUAIFENESIN/CODEINE LIQUID OTC (ORAL) COUGH AND COLD, NARCOTIC MAXI-TUSS CD LIQUID chlorpheniramine/PE/codeine MCR AMERICAN PH SSB MAXI-TUSS CD OTC (ORAL) COUGH AND COLD, NARCOTIC M-CLEAR WC LIQUID codeine phosphate/guaifenesin R.A.MC NEIL CO. SSB M-CLEAR WC LIQUID OTC (ORAL) COUGH AND COLD, NARCOTIC M-END PE LIQUID brompheniramine/p-eph/codeine R.A.MC NEIL CO. SSB M-END PE LIQUID OTC (ORAL) COUGH AND COLD, NARCOTIC NINJACOF-XG LIQUID codeine phosphate/guaifenesin CENTURION LABS SSB NINJACOF-XG LIQUID OTC (ORAL) COUGH AND COLD, NARCOTIC POLY-TUSSIN AC LIQUID brompheniramine/p-eph/codeine POLY PHARMACEUT SSB POLY-TUSSIN AC LIQUID OTC (ORAL) COUGH AND COLD, NARCOTIC PROMETHAZINE VC-CODEINE SOLN promethazine/phenyleph/codeine PHARMACEUTICAL GEN PROMETHAZINE/PHENYLEPHRINE/CODEINE SYRUP (ORAL) COUGH AND COLD, NARCOTIC PROMETHAZINE-CODEINE SOLUTION promethazine HCl/codeine generic GEN PROMETHAZINE/CODEINE SYRUP (ORAL) COUGH AND COLD, NARCOTIC PROMETHAZINE-CODEINE SYRUP promethazine HCl/codeine generic GEN PROMETHAZINE/CODEINE SYRUP (ORAL) COUGH AND COLD, NARCOTIC PROMETHAZINE-PE-CODEINE SYRUP promethazine/phenyleph/codeine HI-TECH/AKORN C GEN PROMETHAZINE/PHENYLEPHRINE/CODEINE SYRUP (ORAL) COUGH AND COLD, NARCOTIC TUSSICAPS 10 MG-8 MG CAPSULE hydrocodone/chlorphen p-stirex VALEANT/BAUSCH SSB TUSSICAPS CAPSULE ER 12H (ORAL) COUGH AND COLD, NARCOTIC VIRTUSSIN AC 10-100 MG/5 ML LQ codeine phosphate/guaifenesin VIRTUS PHARMACE GEN GUAIFENESIN/CODEINE LIQUID OTC (ORAL) COUGH AND COLD, NARCOTIC VIRTUSSIN AC W-ALC 10-100 MG/5 codeine phosphate/guaifenesin VIRTUS PHARMACE GEN GUAIFENESIN/CODEINE LIQUID OTC (ORAL) COUGH AND COLD, NARCOTIC VIRTUSSIN DAC LIQUID pseudoephed/codeine/guaifen VIRTUS PHARMACE GEN GUAIFENESIN/PSE/CODEINE SYRUP OTC (ORAL) COUGH AND COLD, NARCOTIC ALAHIST CF TABLET d-methorphan/pe/dexbromphenir POLY PHARMACEUT SSB ALAHIST CF TABLET OTC (ORAL) COUGH AND COLD, NON-NARCOTIC ALAHIST DM LIQUID d-methorphan/pe/dexbromphenir POLY PHARMACEUT SSB ALA-HIST DM LIQUID OTC (ORAL) COUGH AND COLD, NON-NARCOTIC ALL-NITE COLD-FLU RELIEF LIQ DM/acetaminophen/doxylamine MAJOR PHARMACEU GEN DM/APAP/DOXYLAMINE LIQUID OTC (ORAL) COUGH AND COLD, NON-NARCOTIC AP-HIST DM LIQUID brompheniram/phenylephrine/DM ALLEGIS PHARMAC GEN BROMPHENIRAMINE/PHENYLEPHRINE/DM LIQUID OTC (ORAL) COUGH AND COLD, NON-NARCOTIC AQUANAZ PSE 20-375-60 MG TAB guaifenesin/DM/pseudoephedrine CAPITAL PHARMAC SSB AQUANAZ PSE TABLET OTC (ORAL) COUGH AND COLD, NON-NARCOTIC AQUANAZ TABLET guaifen/dextromethorphan/PE CAPITAL PHARMAC SSB AQUANAZ OTC (ORAL) COUGH AND COLD, NON-NARCOTIC BENZONATATE 100 MG CAPSULE benzonatate generic GEN BENZONATATE CAPSULE (ORAL) COUGH AND COLD, NON-NARCOTIC BENZONATATE 150 MG CAPSULE benzonatate ASCEND LABORATO GEN BENZONATATE CAPSULE (ORAL) COUGH AND COLD, NON-NARCOTIC BENZONATATE 200 MG CAPSULE benzonatate generic GEN BENZONATATE CAPSULE (ORAL) COUGH AND COLD, NON-NARCOTIC BENZONATATE PERLE 100 MG CAP benzonatate GREENSTONE LLC. GEN BENZONATATE CAPSULE (AG) (ORAL) COUGH AND COLD, NON-NARCOTIC BROMFED DM 2-30-10 MG/5 ML SYR brompheniramine/pseudoephed/DM MORTON GROVE PH SSB BROMFED DM SYRUP (ORAL) COUGH AND COLD, NON-NARCOTIC BROMPHEN-PSE-DM 2-30-10 MG/5ML brompheniramine/pseudoephed/DM generic GEN BROM-PSE-DM SYRUP (ORAL) COUGH AND COLD, NON-NARCOTIC CAPMIST DM TABLET guaifenesin/DM/pseudoephedrine CAPITAL PHARMAC SSB CAPMIST DM TABLET OTC (ORAL) COUGH AND COLD, NON-NARCOTIC CAPRON DM LIQUID pyrilamine/dextromethorphan hb CAPITAL PHARMAC SSB CAPRON DM LIQUID OTC (ORAL) COUGH AND COLD, NON-NARCOTIC CAPRON DMT TABLET pyrilamine/dextromethorphan hb CAPITAL PHARMAC SSB CAPRON DMT OTC (ORAL) COUGH AND COLD, NON-NARCOTIC CHEST CONGESTION RELIEF DM LIQ guaifenesin/dextromethorphan RUGBY GEN GUAIFENESIN/DM LIQUID OTC (ORAL) COUGH AND COLD, NON-NARCOTIC CHEST CONGST-COUGH RELIEF TAB guaifenesin/dextromethorphan AMERISOURCE-GNP GEN GUAIFENESIN/DM TABLET OTC (ORAL) COUGH AND COLD, NON-NARCOTIC CHILD COUGH DM ER 30 MG/5 ML dextromethorphan polistirex LEADER GEN DEXTROMETHORPHAN SUSPENSION ER 12H OTC (ORAL) COUGH AND COLD, NON-NARCOTIC CHILD DAYCLEAR ALLERGY CHEW TB pyrilamine/chlophedianol G.M. PHARM SSB CHILDREN'S DAYCLEAR ALLERGY CHEWABLE OTC (ORAL) COUGH AND COLD, NON-NARCOTIC CHILD DELSYM COUGH 30 MG/5 ML dextromethorphan polistirex RECKITT BENCKIS SSB DELSYM SUSPENSION ER 12H OTC (ORAL) COUGH AND COLD, NON-NARCOTIC CHILD DELSYM COUGH PLUS DY-NT diphenhydram/PE/DM/acetamin/GG RECKITT BENCKIS SSB CHILD DELSYM COUGH PLUS DY-NT OTC (ORAL) COUGH AND COLD, NON-NARCOTIC CHILD DELSYM COUGH-CHEST DM LQ guaifenesin/dextromethorphan RECKITT BENCKIS GEN GUAIFENESIN/DM LIQUID OTC (ORAL) COUGH AND COLD, NON-NARCOTIC CHILD MUCINEX COUGH 5-100MG PK guaifenesin/dextromethorphan RECKITT BENCKIS SSB MUCINEX COUGH GRAN PACK OTC (ORAL) COUGH AND COLD, NON-NARCOTIC CHILD MUCINEX FREEFROM DAY CGH guaifenesin/dextromethorphan RECKITT BENCKIS GEN GUAIFENESIN/DM LIQUID OTC (ORAL) COUGH AND COLD, NON-NARCOTIC CHILD MUCINEX FREEFROM NT COLD triprolid/phenyleph/DM/acetam RECKITT BENCKIS SSB CHILD MUCINEX FREEFROM NT COLD LIQUID OTC (ORAL) COUGH AND COLD, NON-NARCOTIC CHILD MUCUS RELIEF COUGH LIQ guaifenesin/dextromethorphan generic GEN GUAIFENESIN/DM LIQUID OTC (ORAL) COUGH AND COLD, NON-NARCOTIC CHILD MUCUS RELIEF M-S COLD LQ guaifen/dextromethorphan/PE generic GEN GUAIFENESIN/DM/PHENYLEPHRINE LIQUID OTC (ORAL) COUGH AND COLD, NON-NARCOTIC CHILD MUCUS-COUGH 5-100 MG/5ML guaifenesin/dextromethorphan LEADER GEN GUAIFENESIN/DM LIQUID OTC (ORAL) COUGH AND COLD, NON-NARCOTIC CHILD MUCUS-COUGH RELIEF LIQ guaifenesin/dextromethorphan LEADER GEN GUAIFENESIN/DM LIQUID OTC (ORAL) COUGH AND COLD, NON-NARCOTIC CHILDREN'S COLD-COUGH ELIXIR brompheniram/phenylephrine/DM TOPCO GEN BROMPHENIRAMINE/PHENYLEPHRINE/DM SOLUTION OTC (ORAL) COUGH AND COLD, NON-NARCOTIC CHILDREN'S COLD-COUGH LIQUID brompheniram/phenylephrine/DM LEADER GEN BROMPHENIRAMINE/PHENYLEPHRINE/DM SOLUTION OTC (ORAL) COUGH AND COLD, NON-NARCOTIC CHILDRENS PLUS M-S COLD SUSP DM/pe/acetaminophen/chlorphenr AMERISOURCE-GNP GEN DM/PHENYLEPHRINE/APAP/CHLORPHENIRAMINE SUSPENSION OTC (ORAL) COUGH AND COLD, NON-NARCOTIC CHILDREN'S PLUS M-S COLD SUSP DM/pe/acetaminophen/chlorphenr TOPCO GEN DM/PHENYLEPHRINE/APAP/CHLORPHENIRAMINE SUSPENSION OTC (ORAL) COUGH AND COLD, NON-NARCOTIC CHLO HIST ORAL SOLUTION dexbrompheniramn/chlophedianol R.A.MC NEIL CO. SSB CHLO HIST SOLUTION OTC (ORAL) COUGH AND COLD, NON-NARCOTIC CHLO TUSS LIQUID dexbromphen/pseudoeph/chlophed R.A.MC NEIL CO. SSB CHLO TUSS LIQUID OTC (ORAL) COUGH AND COLD, NON-NARCOTIC COLD HEAD CONGESTION CAPLET d-methorphan/PE/acetaminophen generic GEN DM/PHENYLEPHRINE/APAP TABLET OTC (ORAL) COUGH AND COLD, NON-NARCOTIC COLD MULTI-SYMPTOM CAPLET DM/pe/acetaminophen/chlorphenr TOPCO GEN DM/PHENYLEPHRINE/APAP/CHLORPHENIRAMINE TABLET OTC (ORAL) COUGH AND COLD, NON-NARCOTIC COLD MULTI-SYMPTOM NIGHT LIQ DM/PE/acetaminophen/doxylamine AMERISOURCE-GNP GEN DM/PHENYLEPHRINE/APAP/DOXYLAMINE LIQUID OTC (ORAL) COUGH AND COLD, NON-NARCOTIC COLD RELIEF HEAD CONGEST CPLT DM/pe/acetaminophen/chlorphenr AMERISOURCE-GNP GEN DM/PHENYLEPHRINE/APAP/CHLORPHENIRAMINE TABLET SEQUELS OTC (ORAL) COUGH AND COLD, NON-NARCOTIC COLD-COUGH ELIXIR brompheniram/phenylephrine/DM AMERISOURCE-GNP GEN BROMPHENIRAMINE/PHENYLEPHRINE/DM SOLUTION OTC (ORAL) COUGH AND COLD, NON-NARCOTIC CONTAC COLD-FLU NIGHT LIQUID DM/acetaminophen/doxylamine MEDA CONSUMER H GEN DM/APAP/DOXYLAMINE LIQUID OTC (ORAL) COUGH AND COLD, NON-NARCOTIC COUGH DM ER 30 MG/5 ML SUSP dextromethorphan polistirex generic GEN DEXTROMETHORPHAN SUSPENSION ER 12H OTC (ORAL) COUGH AND COLD, NON-NARCOTIC COUGH DM SYRUP guaifenesin/dextromethorphan RUGBY GEN GUAIFENESIN/DM LIQUID OTC (ORAL) COUGH AND COLD, NON-NARCOTIC COUGH RELIEF LIQUID dextromethorphan HBr AMERISOURCE-GNP GEN DEXTROMETHORPHAN LIQUID OTC (ORAL) COUGH AND COLD, NON-NARCOTIC COUGH-COLD HBP TABLET chlorpheniramine/dextromethorp LEADER GEN DM/CHLORPHENIRAMINE TABLET OTC (ORAL) COUGH AND COLD, NON-NARCOTIC COUGH-COLD TABLET chlorpheniramine/dextromethorp MAJOR PHARMACEU GEN DM/CHLORPHENIRAMINE TABLET OTC (ORAL) COUGH AND COLD, NON-NARCOTIC DAY MULTI-SYMP FLU-SEVERE COLD d-methorphan/PE/acetaminophen LEADER SSB DAY MULTI-SYMP FLU-SEVERE COLD POWDER PACK OTC (ORAL) COUGH AND COLD, NON-NARCOTIC

2 Cough and Cold; Current Product Listing

LABEL NAME GENERIC NAME MANUFACTURER DRUG TYPE PROVIDER SYNERGIES BRAND NAME ROUTE PROVIDER SYNERGIES MARKET BASKET DAYCLEAR ALLERGY 25-50 MG TAB pyrilamine/chlophedianol G.M. PHARM SSB DAYCLEAR ALLERGY RELIEF OTC (ORAL) COUGH AND COLD, NON-NARCOTIC DAYTIME COLD-FLU RELIEF LIQUID d-methorphan/PE/acetaminophen LEADER GEN DM/PHENYLEPHRINE/APAP LIQUID OTC (ORAL) COUGH AND COLD, NON-NARCOTIC DAYTIME SEVERE COLD-FLU LIQUID phenylephrine/DM/acetaminop/GG LEADER GEN PHENYLEPHRINE/DM/APAP/GUAIFENESIN LIQUID OTC (ORAL) COUGH AND COLD, NON-NARCOTIC DECONEX DMX 17.5-400-10 MG TAB guaifen/dextromethorphan/PE POLY PHARMACEUT SSB DECONEX DMX TABLET OTC (ORAL) COUGH AND COLD, NON-NARCOTIC DELSYM 30 MG/5 ML SUSPENSION dextromethorphan polistirex RECKITT BENCKIS SSB DELSYM SUSPENSION ER 12H OTC (ORAL) COUGH AND COLD, NON-NARCOTIC DELSYM COUGH PLUS DAY-NIGHT LQ diphenhydram/PE/DM/acetamin/GG RECKITT BENCKIS SSB DELSYM COUGH PLUS DAY-NIGHT LIQUID SEQ OTC (ORAL) COUGH AND COLD, NON-NARCOTIC DELSYM COUGH+CHEST CNGST DM LQ guaifenesin/dextromethorphan RECKITT BENCKIS GEN GUAIFENESIN/DM LIQUID OTC (ORAL) COUGH AND COLD, NON-NARCOTIC DELSYM NIGHTTIME COUGH LIQUID triprolidine/DM/acetaminophen RECKITT BENCKIS SSB DELSYM NIGHTTIME MULTI-SYMPTOM LIQUID OTC (ORAL) COUGH AND COLD, NON-NARCOTIC DEXTROMETHORPHAN 15 MG LIQ GEL dextromethorphan HBr RUGBY GEN DEXTROMETHORPHAN CAPSULE OTC (ORAL) COUGH AND COLD, NON-NARCOTIC DEXTROMETHORPHAN ER 30 MG/5 ML dextromethorphan polistirex PERRIGO CO. GEN DEXTROMETHORPHAN SUSPENSION ER 12H OTC (ORAL) COUGH AND COLD, NON-NARCOTIC DIABETIC SILTUSSIN-DM MAX-STR guaifenesin/dextromethorphan SILARX/LANNETT GEN GUAIFENESIN/DM LIQUID OTC (ORAL) COUGH AND COLD, NON-NARCOTIC DIMAPHEN DM ELIXIR brompheniram/phenylephrine/DM MAJOR PHARMACEU GEN BROMPHENIRAMINE/PHENYLEPHRINE/DM SOLUTION OTC (ORAL) COUGH AND COLD, NON-NARCOTIC DM-GUAIF-PE 17.5-385-10 MG TAB guaifen/dextromethorphan/PE WESTMINSTER PHA GEN GUAIFEN/DEXTROMETHORPHAN/PE OTC (ORAL) COUGH AND COLD, NON-NARCOTIC DM-GUAIF-PE 18-200-10 MG/15 ML guaifen/dextromethorphan/PE WESTMINSTER PHA GEN GUAIFENESIN/DM/PHENYLEPHRINE LIQUID OTC (ORAL) COUGH AND COLD, NON-NARCOTIC DURAFLU 325-20-200-60 MG TAB pseudoeph/DM/guaifen/acetamin POLY PHARMACEUT SSB DURAFLU TABLET OTC (ORAL) COUGH AND COLD, NON-NARCOTIC ED A-HIST DM TABLET chlorpheniramine/phenyleph/DM EDWARDS PHARM. SSB ED A-HIST DM TABLET OTC (ORAL) COUGH AND COLD, NON-NARCOTIC ED-A-HIST DM LIQUID chlorpheniramine/phenyleph/DM EDWARDS PHARM. SSB ED-A-HIST DM LIQUID OTC (ORAL) COUGH AND COLD, NON-NARCOTIC ENDACOF-DM LIQUID brompheniram/phenylephrine/DM LARKEN LABS GEN BROMPHENIRAMINE/PHENYLEPHRINE/DM SOLUTION OTC (ORAL) COUGH AND COLD, NON-NARCOTIC FLU HBP 325-2-10 MG CAPLET dextromethorphn/acetaminoph/cp LEADER GEN DM/APAP/CHLORPHENIRAMINE TABLET OTC (ORAL) COUGH AND COLD, NON-NARCOTIC FLU-SEVERE COLD-COUGH DAY PKT d-methorphan/PE/acetaminophen generic GEN DM/PHENYLEPHRINE/APAP POWDER PACK OTC (ORAL) COUGH AND COLD, NON-NARCOTIC GNP MUCUS DM MAX ER 1200-60 MG guaifenesin/dextromethorphan AMERISOURCE-GNP GEN MUCUS DM MAX TABLET ER 12H OTC (ORAL) COUGH AND COLD, NON-NARCOTIC GS CHILD MUCUS RELIEF M-S COLD guaifen/dextromethorphan/PE PERRIGO/GOODSEN GEN GUAIFENESIN/DM/PHENYLEPHRINE LIQUID OTC (ORAL) COUGH AND COLD, NON-NARCOTIC GS CHILD MUCUS RLF COUGH LIQ guaifenesin/dextromethorphan PERRIGO/GOODSEN GEN GUAIFENESIN/DM LIQUID OTC (ORAL) COUGH AND COLD, NON-NARCOTIC GS CHILDREN'S COLD-COUGH SOLN brompheniram/phenylephrine/DM PERRIGO/GOODSEN GEN BROMPHENIRAMINE/PHENYLEPHRINE/DM SOLUTION OTC (ORAL) COUGH AND COLD, NON-NARCOTIC GS CHLD COUGH DM ER 30 MG/5 ML dextromethorphan polistirex PERRIGO/GOODSEN GEN DEXTROMETHORPHAN SUSPENSION ER 12H OTC (ORAL) COUGH AND COLD, NON-NARCOTIC GS COUGH DM ER 30 MG/5 ML SUSP dextromethorphan polistirex PERRIGO/GOODSEN GEN DEXTROMETHORPHAN SUSPENSION ER 12H OTC (ORAL) COUGH AND COLD, NON-NARCOTIC GS DAY TIME COLD-FLU LIQUID d-methorphan/PE/acetaminophen PERRIGO/GOODSEN GEN DM/PHENYLEPHRINE/APAP LIQUID OTC (ORAL) COUGH AND COLD, NON-NARCOTIC GS NIGHTTIME COLD-FLU LIQUID DM/acetaminophen/doxylamine PERRIGO/GOODSEN GEN DM/APAP/DOXYLAMINE LIQUID OTC (ORAL) COUGH AND COLD, NON-NARCOTIC GS NIGHTTIME COLD-FLU SOFTGEL DM/acetaminophen/doxylamine PERRIGO/GOODSEN GEN DM/APAP/DOXYLAMINE CAPSULE OTC (ORAL) COUGH AND COLD, NON-NARCOTIC GS NIGHTTIME COUGH LIQUID dextromethorphan hb/doxylamine PERRIGO/GOODSEN GEN DOXYLAMINE/DM SOLUTION OTC (ORAL) COUGH AND COLD, NON-NARCOTIC GS SEVERE DAY COLD-FLU CAPLET phenylephrine/DM/acetaminop/GG PERRIGO/GOODSEN GEN PHENYLEPHRINE/DM/APAP/GUAIFENESIN CAPLET OTC (ORAL) COUGH AND COLD, NON-NARCOTIC GS SEVERE DAYTIME COLD-FLU LIQ phenylephrine/DM/acetaminop/GG PERRIGO/GOODSEN GEN PHENYLEPHRINE/DM/APAP/GUAIFENESIN LIQUID OTC (ORAL) COUGH AND COLD, NON-NARCOTIC GS TUSSIN CF LIQUID guaifen/dextromethorphan/PE PERRIGO/GOODSEN GEN GUAIFENESIN/DM/PHENYLEPHRINE SYRUP OTC (ORAL) COUGH AND COLD, NON-NARCOTIC GS TUSSIN DM COUGH SYRUP guaifenesin/dextromethorphan PERRIGO/GOODSEN GEN GUAIFENESIN/DM LIQUID OTC (ORAL) COUGH AND COLD, NON-NARCOTIC GS TUSSIN DM COUGH-CHEST SOLN guaifenesin/dextromethorphan PERRIGO/GOODSEN GEN GUAIFENESIN/DM LIQUID OTC (ORAL) COUGH AND COLD, NON-NARCOTIC GS TUSSIN DM LIQUID guaifenesin/dextromethorphan PERRIGO/GOODSEN GEN GUAIFENESIN/DM LIQUID OTC (ORAL) COUGH AND COLD, NON-NARCOTIC GUAIFENESIN DM SYRUP guaifenesin/dextromethorphan generic GEN GUAIFENESIN/DM LIQUID OTC (ORAL) COUGH AND COLD, NON-NARCOTIC GUAIFENESIN-DM 100-10 MG/5 ML guaifenesin/dextromethorphan MAJOR PHARMACEU GEN GUAIFENESIN/DM LIQUID OTC (ORAL) COUGH AND COLD, NON-NARCOTIC GUAIFENESIN-DM 200-20 MG/10 ML guaifenesin/dextromethorphan MAJOR PHARMACEU GEN GUAIFENESIN/DM LIQUID OTC (ORAL) COUGH AND COLD, NON-NARCOTIC GUAIFENESIN-DM ER 1,200-60 MG guaifenesin/dextromethorphan OHM LABS. GEN GUAIFENESIN/DEXTROMETHORPHAN TABLET ER OTC (ORAL) COUGH AND COLD, NON-NARCOTIC HISTEX-DM SYRUP triprolidine/phenylephrine/DM ALLEGIS PHARMAC SSB HISTEX-DM SYRUP OTC (ORAL) COUGH AND COLD, NON-NARCOTIC HM ADT TUSSIN COUGH CONG DM LQ guaifenesin/dextromethorphan HM-STRATEGIC SO GEN GUAIFENESIN/DM LIQUID OTC (ORAL) COUGH AND COLD, NON-NARCOTIC HM ADT TUSSIN M-S COLD LIQUID guaifen/dextromethorphan/PE HM-STRATEGIC SO GEN GUAIFENESIN/DM/PHENYLEPHRINE SYRUP OTC (ORAL) COUGH AND COLD, NON-NARCOTIC HM ADULT TUSSIN DM SYRUP guaifenesin/dextromethorphan HM-STRATEGIC SO GEN GUAIFENESIN/DM LIQUID OTC (ORAL) COUGH AND COLD, NON-NARCOTIC HM CHEST CONGEST RLF DM CAPLET guaifenesin/dextromethorphan HM-STRATEGIC SO GEN GUAIFENESIN/DM TABLET OTC (ORAL) COUGH AND COLD, NON-NARCOTIC HM CHILD MUCUS RELIEF COUGH LQ guaifenesin/dextromethorphan HM-STRATEGIC SO GEN GUAIFENESIN/DM LIQUID OTC (ORAL) COUGH AND COLD, NON-NARCOTIC HM CHILDREN'S COLD-FLU SUSP DM/pe/acetaminophen/chlorphenr HM-STRATEGIC SO GEN DM/PHENYLEPHRINE/APAP/CHLORPHENIRAMINE SUSPENSION OTC (ORAL) COUGH AND COLD, NON-NARCOTIC HM CHILD'S COLD-COUGH ELIXIR brompheniram/phenylephrine/DM HM-STRATEGIC SO GEN BROMPHENIRAMINE/PHENYLEPHRINE/DM SOLUTION OTC (ORAL) COUGH AND COLD, NON-NARCOTIC HM COLD-FLU SEVERE CAPLET phenylephrine/DM/acetaminop/GG HM-STRATEGIC SO GEN PHENYLEPHRINE/DM/APAP/GUAIFENESIN CAPLET OTC (ORAL) COUGH AND COLD, NON-NARCOTIC HM COUGH DM ER 30 MG/5 ML SUSP dextromethorphan polistirex HM-STRATEGIC SO GEN DEXTROMETHORPHAN SUSPENSION ER 12H OTC (ORAL) COUGH AND COLD, NON-NARCOTIC HM DAY SEVERE COLD-FLU CAPLET phenylephrine/DM/acetaminop/GG HM-STRATEGIC SO GEN PHENYLEPHRINE/DM/APAP/GUAIFENESIN CAPLET OTC (ORAL) COUGH AND COLD, NON-NARCOTIC HM DAYTIME COLD-FLU LIQUID d-methorphan/PE/acetaminophen HM-STRATEGIC SO GEN DM/PHENYLEPHRINE/APAP LIQUID OTC (ORAL) COUGH AND COLD, NON-NARCOTIC HM DAYTIME-NIGHTTIME COLD-FLU DM/PE/acetaminophen/doxylamine HM-STRATEGIC SO GEN DM/PHENYLEPHRINE/APAP/DOXYLAMINE CAPSULE SEQUELS OTC (ORAL) COUGH AND COLD, NON-NARCOTIC HM MUCUS DM ER 600-30 MG TAB guaifenesin/dextromethorphan HM-STRATEGIC SO GEN GUAIFENESIN/DM TABLET ER 12H OTC (ORAL) COUGH AND COLD, NON-NARCOTIC HM MUCUS DM MAX ER 1200-60 MG guaifenesin/dextromethorphan HM-STRATEGIC SO GEN MUCUS DM MAX TABLET ER 12H OTC (ORAL) COUGH AND COLD, NON-NARCOTIC HM NIGHT TIME COLD-FLU LIQ DM/acetaminophen/doxylamine HM-STRATEGIC SO GEN DM/APAP/DOXYLAMINE LIQUID OTC (ORAL) COUGH AND COLD, NON-NARCOTIC HM NIGHT TIME LIQUID CAP DM/acetaminophen/doxylamine HM-STRATEGIC SO GEN DM/APAP/DOXYLAMINE CAPSULE OTC (ORAL) COUGH AND COLD, NON-NARCOTIC HM SEVERE COLD-COUGH-FLU PCKT d-methorphan/PE/acetaminophen HM-STRATEGIC SO GEN DM/PHENYLEPHRINE/APAP POWDER PACK OTC (ORAL) COUGH AND COLD, NON-NARCOTIC HM SEVERE COLD-FLU CAPLET phenylephrine/DM/acetaminop/GG HM-STRATEGIC SO GEN PHENYLEPHRINE/DM/APAP/GUAIFENESIN CAPLET OTC (ORAL) COUGH AND COLD, NON-NARCOTIC HM TUSSIN DM 400-20 MG/20 ML guaifenesin/dextromethorphan HM-STRATEGIC SO GEN GUAIFENESIN/DM LIQUID OTC (ORAL) COUGH AND COLD, NON-NARCOTIC LOHIST-DM SYRUP brompheniram/phenylephrine/DM LARKEN LABS SSB LOHIST-DM LIQUID OTC (ORAL) COUGH AND COLD, NON-NARCOTIC MAPAP COLD FORMULA CAPLET d-methorphan/PE/acetaminophen MAJOR PHARMACEU GEN DM/PHENYLEPHRINE/APAP TABLET OTC (ORAL) COUGH AND COLD, NON-NARCOTIC MAXICHLOR PEH DM TABLET chlorpheniramine/phenyleph/DM MCR AMERICAN PH SSB MAXICHLOR PEH DM TABLET OTC (ORAL) COUGH AND COLD, NON-NARCOTIC MAXI-TUSS G LIQUID guaifenesin/dextromethorphan MCR AMERICAN PH GEN GUAIFENESIN/DM LIQUID OTC (ORAL) COUGH AND COLD, NON-NARCOTIC MAXI-TUSS GMX LIQUID guaifenesin/dextromethorphan MCR AMERICAN PH GEN GUAIFENESIN/DM LIQUID OTC (ORAL) COUGH AND COLD, NON-NARCOTIC MAXI-TUSS JR LIQUID dextromethorphan/phenylephrine MCR AMERICAN PH GEN PHENYLEPHRINE/DM LIQUID OTC (ORAL) COUGH AND COLD, NON-NARCOTIC M-END DMX LIQUID dexbromphen/pseudoephedrine/DM R.A.MC NEIL CO. SSB M-END DMX LIQUID OTC (ORAL) COUGH AND COLD, NON-NARCOTIC MICLARA DM LIQUID triprolidine/phenylephrine/DM KEY THERAPEUTIC GEN TRIPROLIDINE/PHENYLEPHRINE/DM SYRUP OTC (ORAL) COUGH AND COLD, NON-NARCOTIC MUCINEX DM ER 1,200-60 MG TAB guaifenesin/dextromethorphan RECKITT BENCKIS SSB MUCINEX DM TABLET ER 12H OTC (ORAL) COUGH AND COLD, NON-NARCOTIC MUCINEX DM ER 600-30 MG TABLET guaifenesin/dextromethorphan RECKITT BENCKIS SSB MUCINEX DM TABLET ER 12H OTC (ORAL) COUGH AND COLD, NON-NARCOTIC MUCINEX FAST-MAX COLD-FLU CAP phenylephrine/DM/acetaminop/GG RECKITT BENCKIS SSB MUCINEX FAST-MAX COLD-FLU CAPSULE OTC (ORAL) COUGH AND COLD, NON-NARCOTIC MUCINEX FAST-MAX COLD-FLU CPLT phenylephrine/DM/acetaminop/GG RECKITT BENCKIS SSB MUCINEX FAST-MAX COLD-FLU TABLET OTC (ORAL) COUGH AND COLD, NON-NARCOTIC MUCINEX FAST-MAX COLD-FLU-THRT phenylephrine/DM/acetaminop/GG RECKITT BENCKIS SSB MUCINEX FAST-MAX COLD-FLU-THROAT CAPSULE OTC (ORAL) COUGH AND COLD, NON-NARCOTIC MUCINEX FAST-MAX COLD-NGHTSHFT triprolidine/PE/DM/acetamin/GG RECKITT BENCKIS SSB MUCINEX FAST-MAX NIGHTSHIFT LIQUID OTC (ORAL) COUGH AND COLD, NON-NARCOTIC MUCINEX FAST-MAX CONGEST-COUGH guaifen/dextromethorphan/PE RECKITT BENCKIS SSB MUCINEX FAST-MAX CONGEST-COUGH TABLET OTC (ORAL) COUGH AND COLD, NON-NARCOTIC MUCINEX FAST-MAX DAY-NITE COLD diphenhydram/PE/DM/acetamin/GG RECKITT BENCKIS SSB MUCINEX FAST-MAX DAY-NITE COLD TABLET SEQUELS OTC (ORAL) COUGH AND COLD, NON-NARCOTIC MUCINEX FAST-MAX DAY-NITE CONG diphenhydram/PE/DM/acetamin/GG RECKITT BENCKIS SSB MUCINEX FAST-MAX DAY-NITE CONG TABLET OTC (ORAL) COUGH AND COLD, NON-NARCOTIC MUCINEX FAST-MAX DAY-NITE LIQ diphenhydram/PE/DM/acetamin/GG RECKITT BENCKIS SSB MUCINEX FAST-MAX DAY-NITE CONG LIQUID OTC (ORAL) COUGH AND COLD, NON-NARCOTIC MUCINEX FAST-MAX DM MAX LIQUID guaifenesin/dextromethorphan RECKITT BENCKIS SSB MUCINEX FAST-MAX DM MAX LIQUID OTC (ORAL) COUGH AND COLD, NON-NARCOTIC MUCINEX FAST-MAX NIGHTSHFT CLR triprolidine/PE/DM/acetamin/GG RECKITT BENCKIS SSB MUCINEX FAST-MAX NIGHTSHIFT LIQUID OTC (ORAL) COUGH AND COLD, NON-NARCOTIC MUCINEX FAST-MAX SEV COLD LIQ phenylephrine/DM/acetaminop/GG RECKITT BENCKIS SSB MUCINEX FAST-MAX SEVERE COLD LIQUID OTC (ORAL) COUGH AND COLD, NON-NARCOTIC MUCINEX FAST-MX CONG-NIGHTSHFT triprolidine/PE/DM/acetamin/GG RECKITT BENCKIS SSB MUCINEX FAST-MX CONG-NIGHTSHFT LIQUID SEQ OTC (ORAL) COUGH AND COLD, NON-NARCOTIC MUCINEX FREEFROM COLD-FLU D-N triprolidine/PE/DM/acetamin/GG RECKITT BENCKIS SSB MUCINEX FREEFROM DAY-NT LIQUID OTC (ORAL) COUGH AND COLD, NON-NARCOTIC MUCINEX FREEFROM NT CLD-FLU LQ triprolid/phenyleph/DM/acetam RECKITT BENCKIS SSB MUCINEX FREEFROM NT COLD-FLU LIQUID OTC (ORAL) COUGH AND COLD, NON-NARCOTIC MUCINEX JUNIOR COLD-FLU CAPLET phenylephrine/DM/acetaminop/GG RECKITT BENCKIS SSB MUCINEX JUNIOR COLD-FLU TABLET OTC (ORAL) COUGH AND COLD, NON-NARCOTIC MUCINEX JUNIOR COUGH-CGST CPLT guaifen/dextromethorphan/PE RECKITT BENCKIS SSB MUCINEX JUNIOR COUGH-CONGEST TABLET OTC (ORAL) COUGH AND COLD, NON-NARCOTIC MUCINEX NIGHTSHFT COLD-FLU CLR triprolid/phenyleph/DM/acetam RECKITT BENCKIS SSB MUCINEX NIGHTSHIFT COLD-FLU LIQUID OTC (ORAL) COUGH AND COLD, NON-NARCOTIC MUCINEX NIGHTSHFT SEVR CLD-FLU triprolid/phenyleph/DM/acetam RECKITT BENCKIS SSB MUCINEX NIGHTSHIFT COLD-FLU LIQUID OTC (ORAL) COUGH AND COLD, NON-NARCOTIC MUCINEX NIGHTSHIFT COLD-FLU LQ triprolidine/DM/acetaminophen RECKITT BENCKIS SSB MUCINEX NIGHTSHIFT COLD-FLU LIQUID OTC (ORAL) COUGH AND COLD, NON-NARCOTIC MUCINEX NIGHTSHIFT SINUS LIQ triprolid/phenyleph/DM/acetam RECKITT BENCKIS SSB MUCINEX NIGHTSHIFT SINUS LIQUID OTC (ORAL) COUGH AND COLD, NON-NARCOTIC MUCINEX SINUS-MAX CONG-PAIN CP d-methorphan/PE/acetaminophen RECKITT BENCKIS GEN MUCINEX SINUS-MAX CONGESTION PAIN OTC (ORAL) COUGH AND COLD, NON-NARCOTIC MUCINEX SINUS-MAX NIGHTSHIFT triprolidine/PE/DM/acetamin/GG RECKITT BENCKIS SSB MUCINEX SINUS-MAX NIGHTSHIFT LIQUID SEQ OTC (ORAL) COUGH AND COLD, NON-NARCOTIC MUCINEX SINUS-MAX PRESSURE-CGH phenylephrine/DM/acetaminop/GG RECKITT BENCKIS GEN MUCINEX SINUS-MAX PRESSURE COUGH OTC (ORAL) COUGH AND COLD, NON-NARCOTIC MUCOSA DM 400-20 MG TABLET guaifenesin/dextromethorphan TIME-CAP LABS GEN GUAIFENESIN/DM TABLET OTC (ORAL) COUGH AND COLD, NON-NARCOTIC MUCUS DM MAX ER 1,200-60 MG TB guaifenesin/dextromethorphan LEADER GEN MUCUS DM MAX TABLET ER 12H OTC (ORAL) COUGH AND COLD, NON-NARCOTIC MUCUS RELIEF DM 20-400 MG TAB guaifenesin/dextromethorphan MAJOR PHARMACEU GEN GUAIFENESIN/DM TABLET OTC (ORAL) COUGH AND COLD, NON-NARCOTIC MUCUS RELIEF DM COUGH TABLET guaifenesin/dextromethorphan LEADER GEN GUAIFENESIN/DM TABLET OTC (ORAL) COUGH AND COLD, NON-NARCOTIC MUCUS RELIEF DM MAX LIQUID guaifenesin/dextromethorphan generic GEN GUAIFENESIN/DM LIQUID OTC (ORAL) COUGH AND COLD, NON-NARCOTIC MUCUS RLF COLD-FLU-THROAT CPLT phenylephrine/DM/acetaminop/GG AMERISOURCE-GNP GEN PHENYLEPHRINE/DM/APAP/GUAIFENESIN CAPLET OTC (ORAL) COUGH AND COLD, NON-NARCOTIC MUCUS RLF DM ER 600-30 MG TAB guaifenesin/dextromethorphan generic GEN GUAIFENESIN/DM TABLET ER 12H OTC (ORAL) COUGH AND COLD, NON-NARCOTIC MUCUS RLF DM MAX ER 1200-60 MG guaifenesin/dextromethorphan generic GEN MUCUS DM MAX TABLET ER 12H OTC (ORAL) COUGH AND COLD, NON-NARCOTIC NIGHT TIME COLD-FLU LIQUID DM/acetaminophen/doxylamine AMERISOURCE-GNP GEN DM/APAP/DOXYLAMINE LIQUID OTC (ORAL) COUGH AND COLD, NON-NARCOTIC NIGHT TIME COLD-FLU SOFTGEL DM/acetaminophen/doxylamine AMERISOURCE-GNP GEN DM/APAP/DOXYLAMINE CAPSULE OTC (ORAL) COUGH AND COLD, NON-NARCOTIC NIGHT TIME COUGH LIQUID dextromethorphan hb/doxylamine AMERISOURCE-GNP GEN DOXYLAMINE/DM SOLUTION OTC (ORAL) COUGH AND COLD, NON-NARCOTIC NIGHTTIME COLD AND FLU LIQUID DM/acetaminophen/doxylamine LEADER GEN DM/APAP/DOXYLAMINE LIQUID OTC (ORAL) COUGH AND COLD, NON-NARCOTIC NIGHTTIME COLD-FLU LIQUID DM/acetaminophen/doxylamine LEADER GEN DM/APAP/DOXYLAMINE LIQUID OTC (ORAL) COUGH AND COLD, NON-NARCOTIC NIGHTTIME COLD-FLU RLF SFTGL DM/acetaminophen/doxylamine generic GEN DM/APAP/DOXYLAMINE CAPSULE OTC (ORAL) COUGH AND COLD, NON-NARCOTIC NIGHTTIME COUGH LIQUID dextromethorphan hb/doxylamine LEADER GEN DOXYLAMINE/DM SOLUTION OTC (ORAL) COUGH AND COLD, NON-NARCOTIC NIGHTTIME SEVERE COLD-FLU LIQ DM/PE/acetaminophen/doxylamine LEADER GEN DM/PHENYLEPHRINE/APAP/DOXYLAMINE LIQUID OTC (ORAL) COUGH AND COLD, NON-NARCOTIC NINJACOF LIQUID pyrilamine/chlophedianol CENTURION LABS SSB NINJACOF LIQUID OTC (ORAL) COUGH AND COLD, NON-NARCOTIC NINJACOF-D LIQUID pyrilamine/pseudoeph/chlophed CENTURION LABS SSB NINJACOF-D OTC (ORAL) COUGH AND COLD, NON-NARCOTIC NOHIST-DM LIQUID chlorpheniramine/phenyleph/DM LARKEN LABS SSB NOHIST-DM LIQUID OTC (ORAL) COUGH AND COLD, NON-NARCOTIC PEDIATRIC COUGH-COLD LIQUID chlorpheniramin/pseudoephed/DM SILARX/LANNETT GEN DM/PSE/CHLORPHENIRAMINE LIQUID OTC (ORAL) COUGH AND COLD, NON-NARCOTIC POLY-HIST DM LIQUID thonzylamine/phenylephrine/DM POLY PHARMACEUT SSB POLY-HIST DM LIQUID OTC (ORAL) COUGH AND COLD, NON-NARCOTIC POLY-HIST PD LIQUID thonzylamine/chlophedianol POLY PHARMACEUT SSB POLY-HIST PD DROPS OTC (ORAL) COUGH AND COLD, NON-NARCOTIC POLYTUSSIN DM SYRUP dexchlorphen/phenylephrine/DM POLY PHARMACEUT SSB POLYTUSSIN DM OTC (ORAL) COUGH AND COLD, NON-NARCOTIC POLY-VENT DM TABLET guaifenesin/DM/pseudoephedrine POLY PHARMACEUT SSB POLY-VENT DM TABLET OTC (ORAL) COUGH AND COLD, NON-NARCOTIC PROMETHAZINE-DM 6.25-15 MG/5ML promethazine/dextromethorphan generic GEN PROMETHAZINE/DM SYRUP (ORAL) COUGH AND COLD, NON-NARCOTIC QC MUCUS RELIEF DM TABLET guaifenesin/dextromethorphan CHAIN DRUG GEN GUAIFENESIN/DM TABLET OTC (ORAL) COUGH AND COLD, NON-NARCOTIC QC NIGHTTIME COLD-FLU SFTGL DM/acetaminophen/doxylamine CHAIN DRUG GEN DM/APAP/DOXYLAMINE CAPSULE OTC (ORAL) COUGH AND COLD, NON-NARCOTIC QC TUSSIN CF LIQUID guaifen/dextromethorphan/PE CHAIN DRUG GEN GUAIFENESIN/DM/PHENYLEPHRINE SYRUP OTC (ORAL) COUGH AND COLD, NON-NARCOTIC QC TUSSIN DM LIQUID guaifenesin/dextromethorphan CHAIN DRUG GEN GUAIFENESIN/DM LIQUID OTC (ORAL) COUGH AND COLD, NON-NARCOTIC

3 Cough and Cold; Current Product Listing

LABEL NAME GENERIC NAME MANUFACTURER DRUG TYPE PROVIDER SYNERGIES BRAND NAME ROUTE PROVIDER SYNERGIES MARKET BASKET RESCON-DM LIQUID chlorpheniramin/pseudoephed/DM CAPELLON SSB RESCON-DM LIQUID OTC (ORAL) COUGH AND COLD, NON-NARCOTIC ROBAFEN CF LIQUID guaifen/dextromethorphan/PE MAJOR PHARMACEU GEN GUAIFENESIN/DM/PHENYLEPHRINE SYRUP OTC (ORAL) COUGH AND COLD, NON-NARCOTIC ROBAFEN DM CGH-CHEST CONG SYRP guaifenesin/dextromethorphan MAJOR PHARMACEU GEN GUAIFENESIN/DM LIQUID OTC (ORAL) COUGH AND COLD, NON-NARCOTIC ROBAFEN DM COUGH LIQUID guaifenesin/dextromethorphan MAJOR PHARMACEU GEN GUAIFENESIN/DM LIQUID OTC (ORAL) COUGH AND COLD, NON-NARCOTIC RYNEX DM LIQUID brompheniram/phenylephrine/DM EDWARDS PHARM. SSB RYNEX DM SOLUTION OTC (ORAL) COUGH AND COLD, NON-NARCOTIC SEVERE COLD-FLU CAPLET phenylephrine/DM/acetaminop/GG LEADER GEN PHENYLEPHRINE/DM/APAP/GUAIFENESIN CAPLET OTC (ORAL) COUGH AND COLD, NON-NARCOTIC SEVERE DAYTIME COLD-FLU LIQ phenylephrine/DM/acetaminop/GG AMERISOURCE-GNP GEN PHENYLEPHRINE/DM/APAP/GUAIFENESIN LIQUID OTC (ORAL) COUGH AND COLD, NON-NARCOTIC SILTUSSIN DM COUGH SYRUP guaifenesin/dextromethorphan SILARX/LANNETT GEN GUAIFENESIN/DM LIQUID OTC (ORAL) COUGH AND COLD, NON-NARCOTIC SILTUSSIN DM DAS 100-10MG/5 ML guaifenesin/dextromethorphan SILARX/LANNETT GEN GUAIFENESIN/DM LIQUID OTC (ORAL) COUGH AND COLD, NON-NARCOTIC SM CHEST CONGEST RLF DM CAPLET guaifenesin/dextromethorphan SM-STRATEGIC SO GEN GUAIFENESIN/DM TABLET OTC (ORAL) COUGH AND COLD, NON-NARCOTIC SM COLD-COUGH DM LIQUID brompheniram/phenylephrine/DM SM-STRATEGIC SO GEN BROMPHENIRAMINE/PHENYLEPHRINE/DM SOLUTION OTC (ORAL) COUGH AND COLD, NON-NARCOTIC SM COLD-FLU SEVERE CAPLET phenylephrine/DM/acetaminop/GG SM-STRATEGIC SO GEN PHENYLEPHRINE/DM/APAP/GUAIFENESIN CAPLET OTC (ORAL) COUGH AND COLD, NON-NARCOTIC SM COUGH & RUNNY NOSE LIQUID chlorpheniramine/dextromethorp SM-STRATEGIC SO GEN DM/CHLORPHENIRAMINE LIQUID OTC (ORAL) COUGH AND COLD, NON-NARCOTIC SM COUGH DM ER 30 MG/5 ML SUSP dextromethorphan polistirex SM-STRATEGIC SO GEN DEXTROMETHORPHAN SUSPENSION ER 12H OTC (ORAL) COUGH AND COLD, NON-NARCOTIC SM DAY TIME COLD-FLU LIQUID d-methorphan/PE/acetaminophen SM-STRATEGIC SO GEN DM/PHENYLEPHRINE/APAP LIQUID OTC (ORAL) COUGH AND COLD, NON-NARCOTIC SM DAY TIME COLD-FLU RELIEF LQ d-methorphan/PE/acetaminophen SM-STRATEGIC SO GEN DM/PHENYLEPHRINE/APAP LIQUID OTC (ORAL) COUGH AND COLD, NON-NARCOTIC SM DAYTIME SOFTGEL DM/pseudoephed/acetaminophen SM-STRATEGIC SO GEN DM/PSE/APAP CAPSULE OTC (ORAL) COUGH AND COLD, NON-NARCOTIC SM MUCUS RELIEF COUGH LIQUID guaifenesin/dextromethorphan SM-STRATEGIC SO GEN GUAIFENESIN/DM LIQUID OTC (ORAL) COUGH AND COLD, NON-NARCOTIC SM NIGHTTIME COLD-FLU SFTGL DM/acetaminophen/doxylamine SM-STRATEGIC SO GEN DM/APAP/DOXYLAMINE CAPSULE OTC (ORAL) COUGH AND COLD, NON-NARCOTIC SM NITE TIME COLD-FLU LIQUID DM/acetaminophen/doxylamine SM-STRATEGIC SO GEN DM/APAP/DOXYLAMINE LIQUID OTC (ORAL) COUGH AND COLD, NON-NARCOTIC SM NITE TIME COLD-FLU REL SFGL DM/p-ephed/acetaminoph/doxylam SM-STRATEGIC SO GEN DM/PSE/APAP/DOXYLAMINE CAPSULE OTC (ORAL) COUGH AND COLD, NON-NARCOTIC SM NITE TIME LIQUID DM/p-ephed/acetaminoph/doxylam SM-STRATEGIC SO GEN PSE/DM/APAP/DOXYLAMINE LIQUID OTC (ORAL) COUGH AND COLD, NON-NARCOTIC SM TUSSIN CF SYRUP guaifen/dextromethorphan/PE SM-STRATEGIC SO GEN GUAIFENESIN/DM/PHENYLEPHRINE SYRUP OTC (ORAL) COUGH AND COLD, NON-NARCOTIC SM TUSSIN DM 400-20 MG/20 ML guaifenesin/dextromethorphan SM-STRATEGIC SO GEN GUAIFENESIN/DM LIQUID OTC (ORAL) COUGH AND COLD, NON-NARCOTIC SM TUSSIN DM LIQUID guaifenesin/dextromethorphan SM-STRATEGIC SO GEN GUAIFENESIN/DM LIQUID OTC (ORAL) COUGH AND COLD, NON-NARCOTIC SM TUSSIN DM SYRUP guaifenesin/dextromethorphan SM-STRATEGIC SO GEN GUAIFENESIN/DM LIQUID OTC (ORAL) COUGH AND COLD, NON-NARCOTIC TUSNEL CAPLET guaifenesin/DM/pseudoephedrine LLORENS PHARM SSB TUSNEL TABLET OTC (ORAL) COUGH AND COLD, NON-NARCOTIC TUSNEL DIABETIC LIQUID guaifenesin/dextromethorphan LLORENS PHARM GEN GUAIFENESIN/DM LIQUID (ORAL) COUGH AND COLD, NON-NARCOTIC TUSNEL DM LIQUID guaifen/dextromethorphan/PE LLORENS PHARM GEN TUSNEL DM LIQUID OTC (ORAL) COUGH AND COLD, NON-NARCOTIC TUSNEL DM PEDIATRIC DROPS guaifenesin/DM/pseudoephedrine LLORENS PHARM SSB TUSNEL-DM PEDIATRIC DROPS OTC (ORAL) COUGH AND COLD, NON-NARCOTIC TUSNEL DM PEDIATRIC LIQUID guaifen/dextromethorphan/PE LLORENS PHARM SSB TUSNEL DM PEDIATRIC LIQUID OTC (ORAL) COUGH AND COLD, NON-NARCOTIC TUSNEL-DM PED 2.5-25-1.25MG/ML guaifen/dextromethorphan/PE LLORENS PHARM SSB TUSNEL DM PEDIATRIC LIQUID OTC (ORAL) COUGH AND COLD, NON-NARCOTIC TUSSIN CF COUGH-COLD LIQUID guaifen/dextromethorphan/PE TOPCO GEN GUAIFENESIN/DM/PHENYLEPHRINE SYRUP OTC (ORAL) COUGH AND COLD, NON-NARCOTIC TUSSIN CF COUGH-COLD SYRUP guaifen/dextromethorphan/PE AMERISOURCE-GNP GEN GUAIFENESIN/DM/PHENYLEPHRINE SYRUP OTC (ORAL) COUGH AND COLD, NON-NARCOTIC TUSSIN CF MAX M-S COLD LIQUID guaifen/dextromethorphan/PE AMERISOURCE-GNP GEN GUAIFENESIN/DM/PHENYLEPHRINE LIQUID OTC (ORAL) COUGH AND COLD, NON-NARCOTIC TUSSIN CF MAX SEVERE M-S COLD phenylephrine/DM/acetaminop/GG LEADER GEN PHENYLEPHRINE/DM/APAP/GUAIFENESIN LIQUID OTC (ORAL) COUGH AND COLD, NON-NARCOTIC TUSSIN CF MULTI-SYMPTOM COLD guaifen/dextromethorphan/PE LEADER GEN GUAIFENESIN/DM/PHENYLEPHRINE SYRUP OTC (ORAL) COUGH AND COLD, NON-NARCOTIC TUSSIN COUGH LIQUID dextromethorphan HBr generic GEN DEXTROMETHORPHAN LIQUID OTC (ORAL) COUGH AND COLD, NON-NARCOTIC TUSSIN DM 400-20 MG TABLET guaifenesin/dextromethorphan AMERISOURCE-GNP GEN GUAIFENESIN/DM TABLET OTC (ORAL) COUGH AND COLD, NON-NARCOTIC TUSSIN DM 400-20 MG/20 ML LIQ guaifenesin/dextromethorphan LEADER GEN GUAIFENESIN/DM LIQUID OTC (ORAL) COUGH AND COLD, NON-NARCOTIC TUSSIN DM CLEAR SYRUP guaifenesin/dextromethorphan AMERISOURCE-GNP GEN GUAIFENESIN/DM LIQUID OTC (ORAL) COUGH AND COLD, NON-NARCOTIC TUSSIN DM LIQUID guaifenesin/dextromethorphan generic GEN GUAIFENESIN/DM LIQUID OTC (ORAL) COUGH AND COLD, NON-NARCOTIC TUSSIN DM MAX LIQUID guaifenesin/dextromethorphan generic GEN GUAIFENESIN/DM LIQUID OTC (ORAL) COUGH AND COLD, NON-NARCOTIC TUSSIN DM SYRUP guaifenesin/dextromethorphan AMERISOURCE-GNP GEN GUAIFENESIN/DM LIQUID OTC (ORAL) COUGH AND COLD, NON-NARCOTIC VANACOF DM 18-200-10 MG/15 ML guaifen/dextromethorphan/PE G.M. PHARM SSB VANACOF DM LIQUID OTC (ORAL) COUGH AND COLD, NON-NARCOTIC VANACOF DMX 18-396-10 MG/15 ML guaifen/dextromethorphan/PE G.M. PHARM SSB VANACOF DMX LIQUID OTC (ORAL) COUGH AND COLD, NON-NARCOTIC VANACOF LIQUID dexchlorphenir/pse/chlophedian G.M. PHARM SSB VANACOF LIQUID OTC (ORAL) COUGH AND COLD, NON-NARCOTIC VANATAB DM CAPLET guaifen/dextromethorphan/PE G.M. PHARM SSB VANATAB DM TABLET OTC (ORAL) COUGH AND COLD, NON-NARCOTIC V-R NON-ASPIRIN FLU GELCAP DM/pseudoephed/acetaminophen SM-STRATEGIC SO GEN PSE/DM/APAP TABLET OTC (ORAL) COUGH AND COLD, NON-NARCOTIC

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