Proposed changes to the 2021 FEI Equine Prohibited Substances List (EPSL) (effective from 01.01.2022)

SUBSTANCE NAME CURRENT PROPOSED COMMENT STATUS EPSL CATEGORY ACETYLCHOLINESTERASE INHIBITOR Used in the treatment of Edrophonium Controlled Banned myasthenia gravis and Medication Substance has no legitimate use in the treatment of sports horses Used to increase Huperzine A Unlisted Banned alertness and treat Substance myasthenia gravis. The substance has no legitimate use in the treatment of sports horses. AMIDES

Palmitoylethanolamid Banned Controlled Used in the treatment of Substance Medication joint pain

ANGIOTENSIN CONVERTING ENZYME INHIBITORS

Enalapril Controlled Banned The substance carries a Medication Substance high risk of abuse and has no legitimate use in the sports horse

Enalaprilat Controlled Banned The substance carries a Medication Substance high risk of abuse and has no legitimate use in the sports horse

Lisinopril Controlled Banned The substance carries a Medication Substance high risk of abuse and has no legitimate use in the sports horse

Moexipril Controlled Banned The substance carries a Medication Substance high risk of abuse and has no legitimate use in the sports horse

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Perindoprilat Controlled Banned The substance carries a Medication Substance high risk of abuse and has no legitimate use in the sports horse ANTIHISTAMINES

Antazoline Controlled Banned The substance has no Medication Substance legitimate use in the sports horse

Azatadine Controlled Banned The substance has Medication Substance sedative effects and no legitimate use in the sports horse

Benzquinamide Controlled Banned The substance has Medication Substance sedative effects and no legitimate use in the sports horse

Bromodiphenhydramine Controlled Banned The substance has Medication Substance sedative effects and no legitimate use in the sports horse

Buclizine Controlled Banned The substance has no Medication Substance legitimate use in the sports horse

Carbinoxamine Controlled Banned The substance has no Medication Substance legitimate use in the sports horse

Chlorcyclizine Controlled Banned The substance has no Medication Substance legitimate use in the sports horse

Chloropyramine Controlled Banned The substance has no Medication Substance legitimate use in the sports horse

Chlorproethazine Controlled Banned The substance has Medication Substance sedative effects and no legitimate use in the sports horse

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Cinnarizine Controlled Banned Causes cerebral dilation Medication Substance and has no legitimate use in the sports horse

Clemastine Controlled Banned The substance has Medication Substance sedative effects and no legitimate use in the sports horse

Clemizole Controlled Banned The substance has no Medication Substance legitimate use in the sports horse

Cyclizine Controlled Banned The substance has no Medication Substance legitimate use in the sports horse

Deptropine Controlled Banned The substance has no Medication Substance legitimate use in the sports horse

Diphenylpyraline Controlled Banned The substance has no Medication Substance legitimate use in the sports horse

Embramine Controlled Banned The substance has no Medication Substance legitimate use in the sports horse

Histapyrrodine Controlled Banned The substance has no Medication Substance legitimate use in the sports horse

Isothipendyl Controlled Banned The substance has Medication Substance sedative effects and no legitimate use in the sports horse

Ketotifen Controlled Banned The substance has Medication Substance sedative effects and no legitimate use in the sports horse

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Mebhydroline Controlled Banned The substance has no Medication Substance legitimate use in the sports horse

Meclizine Controlled Banned The substance has no Medication Substance legitimate use in the sports horse

Medrylamine Controlled Banned The substance has no Medication Substance legitimate use in the sports horse

Methapyrilene Controlled Banned Carcinogenic substance Medication Substance with sedative effects and no legitimate use in the sports horse

Methdilazine Controlled Banned The substance has no Medication Substance legitimate use in the sports horse

Orphenadrine Controlled Banned The substance can be Medication Substance used as a muscle relaxant and has no legitimate use in the sports horse

Phenindamine Controlled Banned The substance has Medication Substance sedative effects and no legitimate use in the sports horse

Phenyltoxamine Controlled Banned The substance has no Medication Substance legitimate use in the sports horse

Promethazine Controlled Banned The substance has Medication Substance sedative effects and no legitimate use in the sports horse

Pyrrobutamine Controlled Banned The substance has no Medication Substance legitimate use in the sports horse

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Terfenadine Controlled Banned Produces adverse cardiac Medication Substance effects and has no legitimate use in the sports horse

Thonzylamine Controlled Banned The substance has no Medication Substance legitimate use in the sports horse

Triprolidine Controlled Banned The substance has Medication Substance sedative effects and no legitimate use in the sports horse ANTI-PLATELET MEDICATION

Clopidogrel Unlisted Controlled Used to treat thrombi Medication and prevent clotting

β-2 AGONISTS

Clorprenaline Controlled Banned The substance has no Medication Substance legitimate use in the sports horse

Indacaterol Unlisted Controlled New pharmaceutical that Medication may be used in the treatment of respiratory disease

Vilanterol Unlisted Controlled New pharmaceutical that Medication may be used in the treatment of respiratory disease HERBS

Chasteberry Unlisted Controlled Used in mares to modify (vitex agnus castus) Medication behaviour associated with oestrus

HORMONES

Chlormadinone acetate Controlled Banned The substance has no Medication Substance legitimate use in horses and has the potential to affect performance

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Delmadinone acetate Controlled Banned Carries a high risk of Medication Substance abuse in affecting performance and behaviour

Medroxyprogesterone Controlled Banned Carries a high risk of Medication Substance abuse in calming horses and has no legitimate therapeutic use IMIDAZOTHIAZOLES

Levamisole Unlisted Controlled Used in the treatment of Medication equine protozoal myeloencephalitis (EPM)

IMMUNE SUPRESSANTS

Azathioprine Banned Controlled May be used as an Substance Medication alternative treatment to corticosteroids

MISCELLANEOUS

Isofluprednisolone Controlled Delist Correction of an error. Medication The substance is unknown.

Thenoic acid Unlisted Controlled Used in the treatment of Medication respiratory disease

NON-STEROIDAL ANTI-INFLAMMATORY DRUGS

Benzydamine Controlled Banned The substances has no Medication Substance legitimate therapeutic use in the sports horse

Grapiprant Unlisted Controlled The substance may be Medication used in the treatment of pain

OPIOIDS

Tilidin Unlisted Banned The substance has no Substance legitimate therapeutic use in the sports horse

PHOSPHODIESTERASE INHIBITORS

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Drotaverine Unlisted Controlled The substance may be Medication used to treat muscular spasms

PSYCHEDELIC

Dimethyltryptamine Banned Banned The substance is derived (DMT) Substance Substance and from plants and grasses Specified found in South America Substance and Europe PSYCHOTROPIC

Cannabidiol Banned Controlled Increasing evidence to (CBD, CBDA) Substance Medication and support its use to treat Specified pain and potential for Substance contamination SELECTIVE OESTROGEN RECEPTOR MODULATORS (SERMs)

Cyclofenil Controlled Banned A substance with (Cyclophenil) Medication Substance anabolic properties and no therapeutic use in the horse

Fulvestrant Controlled Banned The substance has no Medication Substance legitimate use in sports horses

SYMPATHOMIMETICS

1,3-Dimethylamylamine Unlisted Banned Stimulant that can affect (Methylhexanamine; Substance performance and has no DMAA) legitimate use in sports horses VASODILATORS

Vanillyl Butyl Ether Controlled Banned The substance has Medication Substance hyper-sensitising properties and carries risk of abuse INTERNATIONAL THRESHOLDS Addition of a threshold Arsenic Banned Banned for arsenic: Substance Substance and 0.3 microgram total Specified arsenic per millilitre in Substance urine

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