Proposed changes to the 2021 FEI Equine Prohibited Substances List (EPSL) (effective from 01.01.2022) SUBSTANCE NAME CURRENT PROPOSED COMMENT STATUS EPSL CATEGORY ACETYLCHOLINESTERASE INHIBITOR Used in the treatment of Edrophonium Controlled Banned myasthenia gravis and Medication Substance has no legitimate use in the treatment of sports horses Used to increase Huperzine A Unlisted Banned alertness and treat Substance myasthenia gravis. The substance has no legitimate use in the treatment of sports horses. AMIDES Palmitoylethanolamid Banned Controlled Used in the treatment of Substance Medication joint pain ANGIOTENSIN CONVERTING ENZYME INHIBITORS Enalapril Controlled Banned The substance carries a Medication Substance high risk of abuse and has no legitimate use in the sports horse Enalaprilat Controlled Banned The substance carries a Medication Substance high risk of abuse and has no legitimate use in the sports horse Lisinopril Controlled Banned The substance carries a Medication Substance high risk of abuse and has no legitimate use in the sports horse Moexipril Controlled Banned The substance carries a Medication Substance high risk of abuse and has no legitimate use in the sports horse 1 Perindoprilat Controlled Banned The substance carries a Medication Substance high risk of abuse and has no legitimate use in the sports horse ANTIHISTAMINES Antazoline Controlled Banned The substance has no Medication Substance legitimate use in the sports horse Azatadine Controlled Banned The substance has Medication Substance sedative effects and no legitimate use in the sports horse Benzquinamide Controlled Banned The substance has Medication Substance sedative effects and no legitimate use in the sports horse Bromodiphenhydramine Controlled Banned The substance has Medication Substance sedative effects and no legitimate use in the sports horse Buclizine Controlled Banned The substance has no Medication Substance legitimate use in the sports horse Carbinoxamine Controlled Banned The substance has no Medication Substance legitimate use in the sports horse Chlorcyclizine Controlled Banned The substance has no Medication Substance legitimate use in the sports horse Chloropyramine Controlled Banned The substance has no Medication Substance legitimate use in the sports horse Chlorproethazine Controlled Banned The substance has Medication Substance sedative effects and no legitimate use in the sports horse 2 Cinnarizine Controlled Banned Causes cerebral dilation Medication Substance and has no legitimate use in the sports horse Clemastine Controlled Banned The substance has Medication Substance sedative effects and no legitimate use in the sports horse Clemizole Controlled Banned The substance has no Medication Substance legitimate use in the sports horse Cyclizine Controlled Banned The substance has no Medication Substance legitimate use in the sports horse Deptropine Controlled Banned The substance has no Medication Substance legitimate use in the sports horse Diphenylpyraline Controlled Banned The substance has no Medication Substance legitimate use in the sports horse Embramine Controlled Banned The substance has no Medication Substance legitimate use in the sports horse Histapyrrodine Controlled Banned The substance has no Medication Substance legitimate use in the sports horse Isothipendyl Controlled Banned The substance has Medication Substance sedative effects and no legitimate use in the sports horse Ketotifen Controlled Banned The substance has Medication Substance sedative effects and no legitimate use in the sports horse 3 Mebhydroline Controlled Banned The substance has no Medication Substance legitimate use in the sports horse Meclizine Controlled Banned The substance has no Medication Substance legitimate use in the sports horse Medrylamine Controlled Banned The substance has no Medication Substance legitimate use in the sports horse Methapyrilene Controlled Banned Carcinogenic substance Medication Substance with sedative effects and no legitimate use in the sports horse Methdilazine Controlled Banned The substance has no Medication Substance legitimate use in the sports horse Orphenadrine Controlled Banned The substance can be Medication Substance used as a muscle relaxant and has no legitimate use in the sports horse Phenindamine Controlled Banned The substance has Medication Substance sedative effects and no legitimate use in the sports horse Phenyltoxamine Controlled Banned The substance has no Medication Substance legitimate use in the sports horse Promethazine Controlled Banned The substance has Medication Substance sedative effects and no legitimate use in the sports horse Pyrrobutamine Controlled Banned The substance has no Medication Substance legitimate use in the sports horse 4 Terfenadine Controlled Banned Produces adverse cardiac Medication Substance effects and has no legitimate use in the sports horse Thonzylamine Controlled Banned The substance has no Medication Substance legitimate use in the sports horse Triprolidine Controlled Banned The substance has Medication Substance sedative effects and no legitimate use in the sports horse ANTI-PLATELET MEDICATION Clopidogrel Unlisted Controlled Used to treat thrombi Medication and prevent clotting β-2 AGONISTS Clorprenaline Controlled Banned The substance has no Medication Substance legitimate use in the sports horse Indacaterol Unlisted Controlled New pharmaceutical that Medication may be used in the treatment of respiratory disease Vilanterol Unlisted Controlled New pharmaceutical that Medication may be used in the treatment of respiratory disease HERBS Chasteberry Unlisted Controlled Used in mares to modify (vitex agnus castus) Medication behaviour associated with oestrus HORMONES Chlormadinone acetate Controlled Banned The substance has no Medication Substance legitimate use in horses and has the potential to affect performance 5 Delmadinone acetate Controlled Banned Carries a high risk of Medication Substance abuse in affecting performance and behaviour Medroxyprogesterone Controlled Banned Carries a high risk of Medication Substance abuse in calming horses and has no legitimate therapeutic use IMIDAZOTHIAZOLES Levamisole Unlisted Controlled Used in the treatment of Medication equine protozoal myeloencephalitis (EPM) IMMUNE SUPRESSANTS Azathioprine Banned Controlled May be used as an Substance Medication alternative treatment to corticosteroids MISCELLANEOUS Isofluprednisolone Controlled Delist Correction of an error. Medication The substance is unknown. Thenoic acid Unlisted Controlled Used in the treatment of Medication respiratory disease NON-STEROIDAL ANTI-INFLAMMATORY DRUGS Benzydamine Controlled Banned The substances has no Medication Substance legitimate therapeutic use in the sports horse Grapiprant Unlisted Controlled The substance may be Medication used in the treatment of pain OPIOIDS Tilidin Unlisted Banned The substance has no Substance legitimate therapeutic use in the sports horse PHOSPHODIESTERASE INHIBITORS 6 Drotaverine Unlisted Controlled The substance may be Medication used to treat muscular spasms PSYCHEDELIC Dimethyltryptamine Banned Banned The substance is derived (DMT) Substance Substance and from plants and grasses Specified found in South America Substance and Europe PSYCHOTROPIC Cannabidiol Banned Controlled Increasing evidence to (CBD, CBDA) Substance Medication and support its use to treat Specified pain and potential for Substance contamination SELECTIVE OESTROGEN RECEPTOR MODULATORS (SERMs) Cyclofenil Controlled Banned A substance with (Cyclophenil) Medication Substance anabolic properties and no therapeutic use in the horse Fulvestrant Controlled Banned The substance has no Medication Substance legitimate use in sports horses SYMPATHOMIMETICS 1,3-Dimethylamylamine Unlisted Banned Stimulant that can affect (Methylhexanamine; Substance performance and has no DMAA) legitimate use in sports horses VASODILATORS Vanillyl Butyl Ether Controlled Banned The substance has Medication Substance hyper-sensitising properties and carries risk of abuse INTERNATIONAL THRESHOLDS Addition of a threshold Arsenic Banned Banned for arsenic: Substance Substance and 0.3 microgram total Specified arsenic per millilitre in Substance urine 7 .