DOCSLIB.ORG

FEI Prohibited Substances List the 2011 List of FEI Prohibited Substances Will Come Into Effect on 4 April 2011

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
FEI Prohibited Substances List the 2011 List of FEI Prohibited Substances Will Come Into Effect on 4 April 2011 Key to the changes for 2011: A substance highlighted in orange is a NEW addition to the Prohibited List A substance highlighted in blue has BEEN MOVED TO THIS CATEGORY on the Prohibited List A substance highlighted in green has been previously listed but is now REMOVED from the List FEI Prohibited Substances List The 2011 List of FEI Prohibited Substances will come into effect on 4 April 2011. The FEI Prohibited Substances List will be reviewed for suitability and any changes introduced on an annual basis. Please check http://www.fei.org for the latest version of this List. SUBSTANCE ACTIVITY BANNED SUBSTANCES 1 Acebutolol Beta blocker 2 Acefylline Bronchodilator 3 Acemetacin Non-steroidal anti-inflammatory drug 4 Acenocoumarol Anticoagulant 5 Acetanilid Analgesic/antipyretic 6 Acetohexamide Pancreatic stimulant 7 Acetominophen (Paracetamol) Analgesic 8 Acetophenazine Antipsychotic 9 Acetophenetidin (Phenacetin) Analgesic 10 Acetylmorphine Narcotic 11 Adinazolam Anxiolytic 12 Adiphenine Antispasmodic 13 Adrafinil Stimulant 14 Adrenaline Stimulant 15 Adrenochrome Haemostatic 16 Aformoterol Bronchodilator 17 Alclofenac Non-steroidal anti-inflammatory drug 18 Alcuronium Muscle relaxant 19 Aldosterone Hormone 20 Alfentanil Narcotic 21 Allopurinol Xanthine oxidase inhibitor (anti-hyperuricaemia) 22 Almotriptan 5-hydroxatryptamine agonist (antimigraine) 23 Alphadolone acetate Neurosteroid 24 Alphaprodine Opiod analgesic 25 Alpidem Anxiolytic 26 Alprazolam Anxiolytic 27 Alprenolol Beta blocker 28 Althesin IV anaesthetic 29 Althiazide Diuretic 30 Alverine Antispasmodic 31 Ambenonium Cholinesterase inhibition 32 Ambucetamide Antispasmodic 33 Amethocaine Local anaesthetic 34 Amfepramone Stimulant 35 Amfetaminil Stimulant 36 Amidephrine Vasoconstrictor 37 Amiloride Diuretic 38 Amineptine Tricyclic antidepressant 39 Aminoglutehthamide Aromatase inhibitor 1 Key to the changes for 2011: A substance highlighted in orange is a NEW addition to the Prohibited List A substance highlighted in blue has BEEN MOVED TO THIS CATEGORY on the Prohibited List A substance highlighted in green has been previously listed but is now REMOVED from the List FEI Prohibited Substances List The 2011 List of FEI Prohibited Substances will come into effect on 4 April 2011. The FEI Prohibited Substances List will be reviewed for suitability and any changes introduced on an annual basis. Please check http://www.fei.org for the latest version of this List. 40 Aminoheptane Vasopressor 41 Aminomethylbenzoic acid Anti-fibrinolytic 42 Aminopicoline Nitric oxide synthase inhibitor 43 Aminopromazine Antispasmodic 44 Aminopterin Immunosuppressant 45 Amiodarone Anti-arrhythmic 46 Amiphenazole Stimulant 47 Amisometradine Diuretic 48 Amisulpride Antipsychotic 49 Amitriptylline Tricyclic antidepressant 50 Amlodipine Antihypertensive 51 Amobarbital Sedative 52 Amodiaquine Antimalarial 53 Amopyroquine Antimalarial 54 Amoxapine Tricyclic antidepressant 55 Amperozide Antipsychotic 56 Amphetamine Stimulant 57 Amphetaminil Stimulant 58 Ampyrone Non-steroidal anti-inflammatory drug 59 Amrinone Vasodilator 60 Amyl nitrate/nitrite Angina treatment 61 Amylocaine Local anaesthetic 62 Anastrozole Aromatase inhibitor 63 Androstenediol Anabolic 64 Androstenedione Anabolic 65 Anileridrine Opiod analgesic 66 Anilopam Central Nervous System stimulant 67 Anisindione Anticoagulant 68 Anisotropine Anticholinergic 69 Antipyrine Non-steroidal anti-inflammatory drug 70 Apazone (Azapropazone) Non-steroidal anti-inflammatory drug 71 Apocodeine Opiod analgesic 72 Apomorphine Opiod analgesic 73 Aprindine Anti-arrhythmic 74 Aprobarbital Sedative 75 Apronalide Sedative 76 Arecoline Stimulant 77 Arsenic Stimulant/toxic 78 Articaine Local anaesthetic 79 Atenolol Beta blocker 80 Atomoxetine Selective noradrenaline re-uptake inhibitor 81 Atracurium Muscle relaxant 82 Azacyclonal Antipsychotic 2 Key to the changes for 2011: A substance highlighted in orange is a NEW addition to the Prohibited List A substance highlighted in blue has BEEN MOVED TO THIS CATEGORY on the Prohibited List A substance highlighted in green has been previously listed but is now REMOVED from the List FEI Prohibited Substances List The 2011 List of FEI Prohibited Substances will come into effect on 4 April 2011. The FEI Prohibited Substances List will be reviewed for suitability and any changes introduced on an annual basis. Please check http://www.fei.org for the latest version of this List. 83 Azaperone Sedative 84 Azapetine Vasodilator 85 Azapropazone (Apazone) Non-steroidal anti-inflammatory drug 86 Azathioprine Immunosuppressant 87 Baclofen Antispasmodic 88 Bambuterol Bronchodilator 89 Bamifylline Bronchodilator 90 Barbital Sedative 91 Beclamide Sedative 92 Bemegride Stimulant 93 Benactyzine Anticholinergic 94 Benapryzine Anticholinergic 95 Benazepril Antihypertensive 96 Bendroflumethazide Diuretic 97 Benorilate Non-steroidal anti-inflammatory drug 98 Benoxaprofen Non-steroidal anti-inflammatory drug 99 Benoxinate Local anaesthetic 100 Benperidol Antipsychotic 101 Bentazepam Anxiolytic 102 Benzoctamine Sedative 103 Benzonatate Antitussive 104 Benzoylecgonine Stimulant/cocaine metabolite 105 Benzphetamine Stimulant 106 Benzthiazide Diuretic 107 Benztropine Anticholinergic 108 Benzydamine Non-steroidal anti-inflammatory drug 109 Benzylpiperazine Stimulant 110 Bepridil Calcium channel blocker 111 Betaprodine Opiod analgesic 112 Betaxolol Beta blocker 113 Bethanidine Antihypertensive 114 Biperiden Anticholinergic 115 Biphenamine Non-steroidal anti-inflammatory drug 116 Biriperone Antipsychotic 117 Bisoprolol Beta blocker 118 Bitolterol Bronchodilator 119 Bolandiol Anabolic 120 Bolasterone Anabolic 121 Boldenone Anabolic 122 Boldione Anabolic 123 Bretylium Anti-arrhythmic 124 Brimonidine Occular antihypertensive 125 Brinzolamide Diuretic 3 Key to the changes for 2011: A substance highlighted in orange is a NEW addition to the Prohibited List A substance highlighted in blue has BEEN MOVED TO THIS CATEGORY on the Prohibited List A substance highlighted in green has been previously listed but is now REMOVED from the List FEI Prohibited Substances List The 2011 List of FEI Prohibited Substances will come into effect on 4 April 2011. The FEI Prohibited Substances List will be reviewed for suitability and any changes introduced on an annual basis. Please check http://www.fei.org for the latest version of this List. 126 Bromantan Stimulant 127 Bromazepam Anxiolytic 128 Bromfenac Non-steroidal anti-inflammatory drug 129 Bromisovalum Sedative 130 Bromocriptine Dopamine agonist 131 Bromophenethylamine Psychedelic 132 Bromperidol Antipsychotic 133 Brotizolam Anxiolytic 134 Bucetin Analgesic/antipyretic 135 Budesonide Corticosteroid 136 Bufexamac Non-steroidal anti-inflammatory drug 137 Buflomedil Vasoactive agent 138 Bufotenine Naturally occurring hallucinogen 139 Bumetanide Diuretic 140 Bunitrolol Beta adrenergic antagonist 141 Bunolol Beta blocker 142 Buphenine (Nylidrin) Sympathomimetic 143 Bupranolol Beta blocker 144 Bupropion Antidepressant 145 Buspirone Anxiolytic 146 Butabarbital Sedative 147 Butacaine Local anaesthetic 148 Butalbital Sedative 149 Butamben Nerve blocker 150 Butanilicaine Local anaesthetic 151 Butaperazine Antipsychotic 152 Butoctamide Serotonin release stimulation 153 Butofilolol Beta blocker 154 Butoxycaine Local anaesthetic 155 Cafedrine Analeptic 156 Calcium Dobesilate Vasotropic 157 Calusterone Anabolic 158 Camazepam Anxiolytic 159 Candesartan Antihypertensive 160 Cannabis (or synthetic cannabinoids) Psychotropic 161 Canrenone Diuretic 162 Capsaicin Topical analgesic/irritant 163 Captodiame Anxiolytic 164 Caramiphen Anticholinergic 165 Carazolol Beta blocker 166 Carbachol Parasympathomimetic 167 Carbazochrome Haemostatic 168 Carbetapentane (Pentoxyverine) Antitussive 4 Key to the changes for 2011: A substance highlighted in orange is a NEW addition to the Prohibited List A substance highlighted in blue has BEEN MOVED TO THIS CATEGORY on the Prohibited List A substance highlighted in green has been previously listed but is now REMOVED from the List FEI Prohibited Substances List The 2011 List of FEI Prohibited Substances will come into effect on 4 April 2011. The FEI Prohibited Substances List will be reviewed for suitability and any changes introduced on an annual basis. Please check http://www.fei.org for the latest version of this List. 169 Carbidopa Di hydroxythenylalanine decarboxylase inhibitor 170 Carbimazole Antihyperthyroidism 171 Carbocysteine Mucoactive 172 Carbromal Sedative 173 Carbuterol Bronchodilator 174 Carfentanil Opiod analgesic 175 Carisoprodol Muscle relaxant 176 Carphedon (Phenylpiracetam) Stimulant 177 Carphenazine Antipsychotic 178 Carpipramine Anxiolytic 179 Carteolol Beta blocker 180 Carticaine Local anaesthetic 181 Carvedilol Beta blocker 182 Cathine (Norpseudoephedrine) Stimulant 183 Celecoxib Non-steroidal anti-inflammatory drug 184 Celiprolol Beta blocker 185 Cephaeline Emetic 186 Chloral betaine Sedative 187 Chloral hydrate Sedative 188 Chloralbutanol Topical analgesic 189 Chlordiazepoxide Anxiolytic 190 Chlormerodrin Diuretic 191 Chlormethiazole Sedative 192 Chlormezanone Anxiolytic 193 Chloroform Sedative 194 Chlorophenesin Muscle relaxant 195 Chlorophenyl piperazine Psychoactive 196 Chloroprocaine Local anaesthetic 197 Chloroquine Antimalarial 198 Chlorphenoxamine Antipruritic 199 Chlorphentermine Stimulant 200 Chlorpromazine Sedative 201 Chlorpropamide Antidiabetic 202 Chlorprothixene Antipsychotic 203 Chlorthalidone Diuretic 204 Chlorthenoxazine Non-steroidal anti-inflammatory drug
Load more

Recommended publications
  • Non-Steroidal Anti-Inflammatory Agents – Benefits and New Developments for Cancer Pain
    Carr_subbed.qxp 22/5/09 09:49 Page 18 Supportive Oncology Non-steroidal Anti-inflammatory Agents – Benefits and New Developments for Cancer Pain a report by Daniel B Carr1 and Marie Belle D Francia2 1. Saltonstall Professor of Pain Research; 2. Special Scientific Staff, Department of Anesthesiology, Tufts Medical Center DOI: 10.17925/EOH.2008.04.2.18 Pain is one of the complications of cancer that patients most fear, and This article surveys the current role of NSAIDs in the management of its multifactorial aetiology makes it one of the most challenging cancer pain and elucidates newly recognised mechanisms that may conditions to treat.1 A systematic review of epidemiological studies on provide a foundation for the next generation of NSAIDs for analgesia cancer pain published between 1982 and 2001 revealed cancer pain for cancer patients. prevalence rates of at least 14%.2 A more recent systematic review identified prevalence rates of cancer pain in as many as one-third of Mechanism of Analgesic Effects patients after curative treatment and two-thirds of patients NSAIDs are a structurally diverse group of compounds known to undergoing treatment regardless of the stage of disease. The wide prevent the formation of prostanoids (prostaglandins and variation in published prevalence rates is due to heterogeneity of the thromboxane) from arachidonic acid through the inhibition of the populations studied, diverse settings, site of primary cancer and stage enzyme cyclo-oxygenase (COX; see Table 1). COX has two isoenzymes: and methodology used to ascertain prevalence.1 COX-1 is found ubiquitously in most tissues and produces prostaglandins and thromboxane, while COX-2 is located in certain A multimodal approach to the treatment of cancer pain that deploys tissues (brain, blood vessels and so on) and its expression increases both pharmacological and non-pharmacological methods may be during inflammation or fever.
    [Show full text]
  • NCAA [R] Drug-Testing Program, 1999-2000
    DOCUMENT RESUME ED 436 990 HE 032 608 AUTHOR Halpin, Ty, Ed. TITLE NCAA[R] Drug-Testing Program, 1999-2000. INSTITUTION National Collegiate Athletic Association, Indianapolis, IN. PUB DATE 1999-00-00 NOTE 15p. AVAILABLE FROM National Collegiate Athletic Association, P.O. Box 6222, Indianapolis, IN 46206-6222. Tel: 317-917-6222. PUB TYPE Legal/Legislative/Regulatory Materials (090) EDRS PRICE MF01/PC01 Plus Postage. DESCRIPTORS Athletes; *College Athletics; Drug Abuse; *Drug Use Testing; Higher Education; Illegal Drug Use IDENTIFIERS *National Collegiate Athletic Association ABSTRACT The drug testing program supports NCAA's goal to protect the health and safety of student-athletes competing for their institutions, while reaffirming the organization's commitment to fair and equitable competition. Proposal Nos. 30 and 52-54 provide a program for the NCAA's members to ensure that no one athlete has a chemically-induced advantage or is pressured to use chemical substances. The program involves urine collection on specific occasions and laboratory analyses for substances on a list of banned drugs including stimulants, anabolic agents such as steroids, diuretics, illegal drugs, or peptide hormones. Consent forms must be signed by student athletes if they wish to participate in NCAA programs. (JM) Reproductions supplied by EDRS are the best that can be made from the original document. 6' 3r; - RUG- ESTING ROGRAI4 1999-2000 , Pso (2 BEST COPY AVAILABLE U.S. DEPARTMENT OF EDUCATION Office of Educational Research and Improvement PERMISSION TO REPRODUCE AND EDUCATIONAL RESOURCES INFORMATION DISSEMINATE THIS MATERIAL HAS CENTER (ERIC) BEEN GRANTED BY his document has been reproduced as received from the person or organization originating it.
    [Show full text]
  • The National Drugs List
    ^ ^ ^ ^ ^[ ^ The National Drugs List Of Syrian Arab Republic Sexth Edition 2006 ! " # "$ % &'() " # * +$, -. / & 0 /+12 3 4" 5 "$ . "$ 67"5,) 0 " /! !2 4? @ % 88 9 3: " # "$ ;+<=2 – G# H H2 I) – 6( – 65 : A B C "5 : , D )* . J!* HK"3 H"$ T ) 4 B K<) +$ LMA N O 3 4P<B &Q / RS ) H< C4VH /430 / 1988 V W* < C A GQ ") 4V / 1000 / C4VH /820 / 2001 V XX K<# C ,V /500 / 1992 V "!X V /946 / 2004 V Z < C V /914 / 2003 V ) < ] +$, [2 / ,) @# @ S%Q2 J"= [ &<\ @ +$ LMA 1 O \ . S X '( ^ & M_ `AB @ &' 3 4" + @ V= 4 )\ " : N " # "$ 6 ) G" 3Q + a C G /<"B d3: C K7 e , fM 4 Q b"$ " < $\ c"7: 5) G . HHH3Q J # Hg ' V"h 6< G* H5 !" # $%" & $' ,* ( )* + 2 ا اوا ادو +% 5 j 2 i1 6 B J' 6<X " 6"[ i2 "$ "< * i3 10 6 i4 11 6! ^ i5 13 6<X "!# * i6 15 7 G!, 6 - k 24"$d dl ?K V *4V h 63[46 ' i8 19 Adl 20 "( 2 i9 20 G Q) 6 i10 20 a 6 m[, 6 i11 21 ?K V $n i12 21 "% * i13 23 b+ 6 i14 23 oe C * i15 24 !, 2 6\ i16 25 C V pq * i17 26 ( S 6) 1, ++ &"r i19 3 +% 27 G 6 ""% i19 28 ^ Ks 2 i20 31 % Ks 2 i21 32 s * i22 35 " " * i23 37 "$ * i24 38 6" i25 39 V t h Gu* v!* 2 i26 39 ( 2 i27 40 B w< Ks 2 i28 40 d C &"r i29 42 "' 6 i30 42 " * i31 42 ":< * i32 5 ./ 0" -33 4 : ANAESTHETICS $ 1 2 -1 :GENERAL ANAESTHETICS AND OXYGEN 4 $1 2 2- ATRACURIUM BESYLATE DROPERIDOL ETHER FENTANYL HALOTHANE ISOFLURANE KETAMINE HCL NITROUS OXIDE OXYGEN PROPOFOL REMIFENTANIL SEVOFLURANE SUFENTANIL THIOPENTAL :LOCAL ANAESTHETICS !67$1 2 -5 AMYLEINE HCL=AMYLOCAINE ARTICAINE BENZOCAINE BUPIVACAINE CINCHOCAINE LIDOCAINE MEPIVACAINE OXETHAZAINE PRAMOXINE PRILOCAINE PREOPERATIVE MEDICATION & SEDATION FOR 9*: ;< " 2 -8 : : SHORT -TERM PROCEDURES ATROPINE DIAZEPAM INJ.
    [Show full text]
  • Product List March 2019 - Page 1 of 53
    Wessex has been sourcing and supplying active substances to medicine manufacturers since its incorporation in 1994. We supply from known, trusted partners working to full cGMP and with full regulatory support. Please contact us for details of the following products. Product CAS No. ( R)-2-Methyl-CBS-oxazaborolidine 112022-83-0 (-) (1R) Menthyl Chloroformate 14602-86-9 (+)-Sotalol Hydrochloride 959-24-0 (2R)-2-[(4-Ethyl-2, 3-dioxopiperazinyl) carbonylamino]-2-phenylacetic 63422-71-9 acid (2R)-2-[(4-Ethyl-2-3-dioxopiperazinyl) carbonylamino]-2-(4- 62893-24-7 hydroxyphenyl) acetic acid (r)-(+)-α-Lipoic Acid 1200-22-2 (S)-1-(2-Chloroacetyl) pyrrolidine-2-carbonitrile 207557-35-5 1,1'-Carbonyl diimidazole 530-62-1 1,3-Cyclohexanedione 504-02-9 1-[2-amino-1-(4-methoxyphenyl) ethyl] cyclohexanol acetate 839705-03-2 1-[2-Amino-1-(4-methoxyphenyl) ethyl] cyclohexanol Hydrochloride 130198-05-9 1-[Cyano-(4-methoxyphenyl) methyl] cyclohexanol 93413-76-4 1-Chloroethyl-4-nitrophenyl carbonate 101623-69-2 2-(2-Aminothiazol-4-yl) acetic acid Hydrochloride 66659-20-9 2-(4-Nitrophenyl)ethanamine Hydrochloride 29968-78-3 2,4 Dichlorobenzyl Alcohol (2,4 DCBA) 1777-82-8 2,6-Dichlorophenol 87-65-0 2.6 Diamino Pyridine 136-40-3 2-Aminoheptane Sulfate 6411-75-2 2-Ethylhexanoyl Chloride 760-67-8 2-Ethylhexyl Chloroformate 24468-13-1 2-Isopropyl-4-(N-methylaminomethyl) thiazole Hydrochloride 908591-25-3 4,4,4-Trifluoro-1-(4-methylphenyl)-1,3-butane dione 720-94-5 4,5,6,7-Tetrahydrothieno[3,2,c] pyridine Hydrochloride 28783-41-7 4-Chloro-N-methyl-piperidine 5570-77-4
    [Show full text]
  • Did Internet-Purchased Diet Pills Cause Serotonin Syndrome?
    Did Internet-purchased diet pills cause serotonin syndrome? Phentermine also may have increased patient’s neuroleptic malignant syndrome risk s. G, age 28, presents to a tertiary® careDowden hospital Health Media with altered mental status. Six weeks ago she Mstarted taking phentermine, 37.5 mg/d, to lose weight. Her body mass indexCopyright is 24 kg/mFor2 (normal personal range), use only and she obtained the stimulant agent via the Internet. Her family reports Ms. G was very busy in the past week, staying up until 2 AM cleaning. They say she also was irritable with her 5-year-old son. Two days ago, Ms. G complained of fatigue and nausea without emesis. She went to bed early and did not awaken the next morning. Her sister found her in bed, minimally re- DIONISI sponsive to verbal stimuli, and brought her to the hospital. Patients have used phentermine as a weight-reducing IMAGES/SANDRA GETTY agent since the FDA approved this amphetamine-like © compound in 1960.1 Phentermine’s mechanism of ac- tion is thought to involve dopaminergic, noradrenergic, Kyoung Bin Im, MD and serotonergic effects.2 Stimulation of norepineph- Chief resident Internal medicine and psychiatry combined residency program rine (NE) release is its most potent effect, followed Departments of internal medicine and psychiatry by NE reuptake inhibition, stimulation of dopamine Jess G. Fiedorowicz, MD (DA) release, DA reuptake inhibition, stimulation of Associate in psychiatry serotonin (5-HT) release, and 5-HT reuptake inhibition Department of psychiatry (weak).3 Roy J. and Lucille A. Carver College of Medicine Because phentermine could in theory cause serotonin 4 University of Iowa syndrome, its use is contraindicated with monoamine Iowa City oxidase inhibitors (MAOIs) and not recommended with selective serotonin reuptake inhibitors (SSRIs).5 One case report describes an interaction between fl uox- etine and phentermine that appears consistent with se- rotonin syndrome.6 We are aware of no case reports of Current Psychiatry serotonin syndrome caused by phentermine alone.
    [Show full text]
  • Use of Aspirin and Nsaids to Prevent Colorectal Cancer
    Evidence Synthesis Number 45 Use of Aspirin and NSAIDs to Prevent Colorectal Cancer Prepared for: Agency for Healthcare Research and Quality U.S. Department of Health and Human Services 540 Gaither Road Rockville, MD 20850 www.ahrq.gov Contract No. 290-02-0021 Prepared by: University of Ottawa Evidence-based Practice Center at The University of Ottawa, Ottawa Canada David Moher, PhD Director Investigators Alaa Rostom, MD, MSc, FRCPC Catherine Dube, MD, MSc, FRCPC Gabriela Lewin, MD Alexander Tsertsvadze, MD Msc Nicholas Barrowman, PhD Catherine Code, MD, FRCPC Margaret Sampson, MILS David Moher, PhD AHRQ Publication No. 07-0596-EF-1 March 2007 This report is based on research conducted by the University of Ottawa Evidence-based Practice Center (EPC) under contract to the Agency for Healthcare Research and Quality (AHRQ), Rockville, MD (Contract No. 290-02-0021). Funding was provided by the Centers for Disease Control and Prevention. The findings and conclusions in this document are those of the author(s), who are responsible for its content, and do not necessarily represent the views of AHRQ. No statement in this report should be construed as an official position of AHRQ or of the U.S. Department of Health and Human Services. The information in this report is intended to help clinicians, employers, policymakers, and others make informed decisions about the provision of health care services. This report is intended as a reference and not as a substitute for clinical judgment. This document is in the public domain and may be used and reprinted without permission except those copyrighted materials noted for which further reproduction is prohibited without the specific permission of copyright holders.
    [Show full text]
  • Classification of Medicinal Drugs and Driving: Co-Ordination and Synthesis Report
    Project No. TREN-05-FP6TR-S07.61320-518404-DRUID DRUID Driving under the Influence of Drugs, Alcohol and Medicines Integrated Project 1.6. Sustainable Development, Global Change and Ecosystem 1.6.2: Sustainable Surface Transport 6th Framework Programme Deliverable 4.4.1 Classification of medicinal drugs and driving: Co-ordination and synthesis report. Due date of deliverable: 21.07.2011 Actual submission date: 21.07.2011 Revision date: 21.07.2011 Start date of project: 15.10.2006 Duration: 48 months Organisation name of lead contractor for this deliverable: UVA Revision 0.0 Project co-funded by the European Commission within the Sixth Framework Programme (2002-2006) Dissemination Level PU Public PP Restricted to other programme participants (including the Commission x Services) RE Restricted to a group specified by the consortium (including the Commission Services) CO Confidential, only for members of the consortium (including the Commission Services) DRUID 6th Framework Programme Deliverable D.4.4.1 Classification of medicinal drugs and driving: Co-ordination and synthesis report. Page 1 of 243 Classification of medicinal drugs and driving: Co-ordination and synthesis report. Authors Trinidad Gómez-Talegón, Inmaculada Fierro, M. Carmen Del Río, F. Javier Álvarez (UVa, University of Valladolid, Spain) Partners - Silvia Ravera, Susana Monteiro, Han de Gier (RUGPha, University of Groningen, the Netherlands) - Gertrude Van der Linden, Sara-Ann Legrand, Kristof Pil, Alain Verstraete (UGent, Ghent University, Belgium) - Michel Mallaret, Charles Mercier-Guyon, Isabelle Mercier-Guyon (UGren, University of Grenoble, Centre Regional de Pharmacovigilance, France) - Katerina Touliou (CERT-HIT, Centre for Research and Technology Hellas, Greece) - Michael Hei βing (BASt, Bundesanstalt für Straßenwesen, Germany).
    [Show full text]
  • Predicting Toxicity from Gene Expression with Neural Networks
    Predicting Toxicity from Gene Expression with Neural Networks Peter Eastman1 and Vijay S. Pande1 1Department of Bioengineering, Stanford University, Stanford, CA 94305 Abstract We train a neural network to predict chemical toxicity based on gene expression data. The input to the network is a full expression profile collected either in vitro from cultured cells or in vivo from live animals. The output is a set of fine grained predictions for the presence of a variety of pathological effects in treated animals. When trained on the Open TG-GATEs database it produces good results, outperforming classical models trained on the same data. This is a promising approach for efficiently screening chemicals for toxic effects, and for more accurately evaluating drug candidates based on preclinical data. Introduction Predicting toxicity is a vital problem in many fields. One quarter of all drug candidates that reach phase II clinical trials ultimately fail because of toxicity[1]. Better methods to predict this in advance would spare patients from taking drugs that ultimately prove toxic, as well as saving enormous time and money. Toxic effects from industrial and household chemicals are also a major public health problem. Often they are tested only on animals, not humans, but animals can be a poor model for toxicity in humans[2]. Better methods to predict human toxicity would have major public health benefits. Many chemicals cause chronic rather than acute toxicity. It may take months or years for their effects to become apparent. Better methods to spot the early signs of chronic toxicity before clinical symptoms appear would allow clinical trials to be stopped sooner, and also would reduce the risk of toxic effects being missed.
    [Show full text]
  • (19) United States (12) Patent Application Publication (10) Pub
    US 20130289061A1 (19) United States (12) Patent Application Publication (10) Pub. No.: US 2013/0289061 A1 Bhide et al. (43) Pub. Date: Oct. 31, 2013 (54) METHODS AND COMPOSITIONS TO Publication Classi?cation PREVENT ADDICTION (51) Int. Cl. (71) Applicant: The General Hospital Corporation, A61K 31/485 (2006-01) Boston’ MA (Us) A61K 31/4458 (2006.01) (52) U.S. Cl. (72) Inventors: Pradeep G. Bhide; Peabody, MA (US); CPC """"" " A61K31/485 (201301); ‘4161223011? Jmm‘“ Zhu’ Ansm’ MA. (Us); USPC ......... .. 514/282; 514/317; 514/654; 514/618; Thomas J. Spencer; Carhsle; MA (US); 514/279 Joseph Biederman; Brookline; MA (Us) (57) ABSTRACT Disclosed herein is a method of reducing or preventing the development of aversion to a CNS stimulant in a subject (21) App1_ NO_; 13/924,815 comprising; administering a therapeutic amount of the neu rological stimulant and administering an antagonist of the kappa opioid receptor; to thereby reduce or prevent the devel - . opment of aversion to the CNS stimulant in the subject. Also (22) Flled' Jun‘ 24’ 2013 disclosed is a method of reducing or preventing the develop ment of addiction to a CNS stimulant in a subj ect; comprising; _ _ administering the CNS stimulant and administering a mu Related U‘s‘ Apphcatlon Data opioid receptor antagonist to thereby reduce or prevent the (63) Continuation of application NO 13/389,959, ?led on development of addiction to the CNS stimulant in the subject. Apt 27’ 2012’ ?led as application NO_ PCT/US2010/ Also disclosed are pharmaceutical compositions comprising 045486 on Aug' 13 2010' a central nervous system stimulant and an opioid receptor ’ antagonist.
    [Show full text]
  • Properties and Units in Clinical Pharmacology and Toxicology
    Pure Appl. Chem., Vol. 72, No. 3, pp. 479–552, 2000. © 2000 IUPAC INTERNATIONAL FEDERATION OF CLINICAL CHEMISTRY AND LABORATORY MEDICINE SCIENTIFIC DIVISION COMMITTEE ON NOMENCLATURE, PROPERTIES, AND UNITS (C-NPU)# and INTERNATIONAL UNION OF PURE AND APPLIED CHEMISTRY CHEMISTRY AND HUMAN HEALTH DIVISION CLINICAL CHEMISTRY SECTION COMMISSION ON NOMENCLATURE, PROPERTIES, AND UNITS (C-NPU)§ PROPERTIES AND UNITS IN THE CLINICAL LABORATORY SCIENCES PART XII. PROPERTIES AND UNITS IN CLINICAL PHARMACOLOGY AND TOXICOLOGY (Technical Report) (IFCC–IUPAC 1999) Prepared for publication by HENRIK OLESEN1, DAVID COWAN2, RAFAEL DE LA TORRE3 , IVAN BRUUNSHUUS1, MORTEN ROHDE1, and DESMOND KENNY4 1Office of Laboratory Informatics, Copenhagen University Hospital (Rigshospitalet), Copenhagen, Denmark; 2Drug Control Centre, London University, King’s College, London, UK; 3IMIM, Dr. Aiguader 80, Barcelona, Spain; 4Dept. of Clinical Biochemistry, Our Lady’s Hospital for Sick Children, Crumlin, Dublin 12, Ireland #§The combined Memberships of the Committee and the Commission (C-NPU) during the preparation of this report (1994–1996) were as follows: Chairman: H. Olesen (Denmark, 1989–1995); D. Kenny (Ireland, 1996); Members: X. Fuentes-Arderiu (Spain, 1991–1997); J. G. Hill (Canada, 1987–1997); D. Kenny (Ireland, 1994–1997); H. Olesen (Denmark, 1985–1995); P. L. Storring (UK, 1989–1995); P. Soares de Araujo (Brazil, 1994–1997); R. Dybkær (Denmark, 1996–1997); C. McDonald (USA, 1996–1997). Please forward comments to: H. Olesen, Office of Laboratory Informatics 76-6-1, Copenhagen University Hospital (Rigshospitalet), 9 Blegdamsvej, DK-2100 Copenhagen, Denmark. E-mail: [email protected] Republication or reproduction of this report or its storage and/or dissemination by electronic means is permitted without the need for formal IUPAC permission on condition that an acknowledgment, with full reference to the source, along with use of the copyright symbol ©, the name IUPAC, and the year of publication, are prominently visible.
    [Show full text]
  • <I>Iguana Iguana</I>
    Journal of the American Association for Laboratory Animal Science Vol 58, No 6 Copyright 2019 November 2019 by the American Association for Laboratory Animal Science Pages 810–816 Use of Rodent Sedation Tests to Evaluate Midazolam and Flumazenil in Green Iguanas (Iguana iguana) Thais F Bressan, Thayanee Sobreira, and Adriano B Carregaro* This study aimed to evaluate the applicability of rodent behavioral tests to assess the effects of midazolam and flumazenil in green iguanas. Four tests commonly used to assess sedation in rodents—the open field test, forced swim test, behavioral scale, and traction test—were conducted in 10 juveniles iguanas. The animals received midazolam (2 mg/kg IM) or 0.9% NaCl (0.4 mL/kg IM), and the tests were conducted between 0 and 300 min thereafter. To verify the effects of midazolam and flumazenil, the most informative tests from the evaluation stage and the limb withdrawal latency time (LWLT) were used. All 10 iguanas were tested under 4 conditions, as follows: MS, midazolam (2 mg/kg IM), followed 30 min later by 0.9% NaCl (0.4 mL/kg IM); FS, flumazenil (0.05 mg/kg IM), followed by 0.9% NaCl (0.4 mL/kg IM) 30 min later; MF, midazolam (2 mg/ kg IM), followed by flumazenil (0.05 mg/kg IM) 30 min later; and CON, 0.9% NaCl (0.4 mL/kg IM). The behavioral scale and the forced swim test showed the best detection of the onset, peak effect, and the differences between the sedated and con- trol iguanas, with testing done between 15 and 240 min after drug administration.
    [Show full text]
  • Download Drug Labels List
    Syringe Labelling System Price Per Label Description/Drug Name Item No. Quanitiy Per Pack Pack Abciximab 99801 2 x 500 roll's £6.30 Abidec 100602 2 x 500 roll's £6.30 Acepromazine 99802 2 x 500 roll's £6.30 Acetazolamide 99803 2 x 500 roll's £6.30 Acetylcholine 99804 2 x 500 roll's £6.30 Acetylcysteine 99805 2 x 500 roll's £6.30 Acetylsalicylic Acid 99806 2 x 500 roll's £6.30 Aciclovir 99807 2 x 500 roll's £6.30 ACP/Buprenorphine 100208 2 x 500 roll's £6.30 Actrapid Insulin 99808 2 x 500 roll's £6.30 Adenosine 99809 2 x 500 roll's £6.30 Adrenaline (Top Half Black, Bottom Violet, Violet Text) 99810 2 x 500 roll's £6.30 Adrenaline/Epinephrine 99811 2 x 500 roll's £6.30 Albumin Solution 99812 2 x 500 roll's £6.30 Alchol 99813 2 x 500 roll's £6.30 Alemtuzmab 99814 2 x 500 roll's £6.30 ALERT 100243 2 x 500 roll's £6.30 Alfaxalone 99815 2 x 500 roll's £6.30 Alfentanil 99816 2 x 500 roll's £6.30 Alfentanil 99817 2 x 500 roll's £6.30 Alteplase 99818 2 x 500 roll's £6.30 Amikacin 99819 2 x 500 roll's £6.30 Aminophylline 99820 2 x 500 roll's £6.30 Amiodarone 100194 2 x 500 roll's £6.30 Amoxicillin 100195 2 x 500 roll's £6.30 Amphotericin 99821 2 x 500 roll's £6.30 Ampicillin 99822 2 x 500 roll's £6.30 Antibiotic 99823 2 x 500 roll's £6.30 Anticoagulant 99824 2 x 500 roll's £6.30 Antifungal 100228 2 x 500 roll's £6.30 Antiseptic 99825 2 x 500 roll's £6.30 Aprotinin 99826 2 x 500 roll's £6.30 Aqueous Iodine 99827 2 x 500 roll's £6.30 Arterial 100259 2 x 500 roll's £6.30 Arterial ( Line Label - White with Red Writing) 100176 2 x 500 roll's £6.30 Arterial
    [Show full text]